Version 1
: Received: 13 December 2023 / Approved: 14 December 2023 / Online: 14 December 2023 (12:15:47 CET)
How to cite:
An, R.; Wang, X.; Xiong, L.; Yang, Y.; Li, P. TNF-α Inhibitors Rescue APS-Induced Dangerous Pregnancies by Reducing the Risk of Miscarriage: A Report of 7 Cases. Preprints2023, 2023121085. https://doi.org/10.20944/preprints202312.1085.v1
An, R.; Wang, X.; Xiong, L.; Yang, Y.; Li, P. TNF-α Inhibitors Rescue APS-Induced Dangerous Pregnancies by Reducing the Risk of Miscarriage: A Report of 7 Cases. Preprints 2023, 2023121085. https://doi.org/10.20944/preprints202312.1085.v1
An, R.; Wang, X.; Xiong, L.; Yang, Y.; Li, P. TNF-α Inhibitors Rescue APS-Induced Dangerous Pregnancies by Reducing the Risk of Miscarriage: A Report of 7 Cases. Preprints2023, 2023121085. https://doi.org/10.20944/preprints202312.1085.v1
APA Style
An, R., Wang, X., Xiong, L., Yang, Y., & Li, P. (2023). TNF-α Inhibitors Rescue APS-Induced Dangerous Pregnancies by Reducing the Risk of Miscarriage: A Report of 7 Cases. Preprints. https://doi.org/10.20944/preprints202312.1085.v1
Chicago/Turabian Style
An, R., Yanqi Yang and Peiling Li. 2023 "TNF-α Inhibitors Rescue APS-Induced Dangerous Pregnancies by Reducing the Risk of Miscarriage: A Report of 7 Cases" Preprints. https://doi.org/10.20944/preprints202312.1085.v1
Abstract
Antiphospholipid syndrome (APS) is a group of autoimmune diseases caused by antiphospholipid antibodies (aPLs) characterized by arteriovenous thrombosis and a morbid pregnancy. We deliberated a case report of seven cases to investigate whether inhibitors of tissue necrosis factor-α could reduce pregnancy dangers caused by APS.
The seven patients are with increased tumor necrosis factor, poor improvement after receiving traditional inhibitory drugs. To address these situations, the tumor necrosis factor inhibitors were prescribed after getting the patient's informed consent, and the state of illness was carefully watched for. After treatment, symptoms of contractions and abdominal pain disappeared and the B ultrasound examination showed embryo survived with good obstetric outcomes. Subsequently, maternal and neonatal health is compromised. An intervention by the administration of TNF-α inhibitors was posited to be an effective way of reducing dangerous pregnancies like preterm pregnancies, premature deliveries, abortions and miscarriages.
We reviewed outcomes from seven cases in an attempt to establish how TNF- α Inhibitors could save pregnancies. We focused on key pregnancy outcomes like birth weight, gestational weeks and preterm miscarriage to tell the outcomes of TNF- α Inhibitors in pregnancy. After careful evaluation of the results surrounding these aspects, we found that TNF- α Inhibitors could prolong gestational period. Other positive outcomes include the attainment of birth weights approach the threshold, zero incidence of preterm miscarriage.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
