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Preprint ARTICLE | doi:10.20944/preprints201902.0255.v1

Bayesian Structural Equation Modeling for Examining the Relationship between Multidimensional Factors and Construction Project Cost

Linlin Zhao, Zhansheng Liu, Jasper Mbachu

Subject: Engineering, Civil Engineering Keywords: Construction project cost; influencing factors; Bayesian SEM; New Zealand

Online: 27 February 2019 (12:01:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0217.v1

Bayesian Structural Equation Modeling for Examining the Relationship between Multidimensional Factors and Construction Project Cost

Linlin Zhao, Zhansheng Liu, Jasper Mbachu

Subject: Engineering, Architecture, Building And Construction Keywords: Construction project cost; influencing factors; Bayesian SEM; New Zealand

Online: 25 February 2019 (08:41:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0706.v1

Infant Food Security in New Zealand: A Multidimensional Index Developed from Cohort Data

Deborah Schlichting, Ladan Hashemi, Cameron Grant

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: food security; paediatrics; cohort study; New Zealand; developed country

Online: 30 October 2018 (05:29:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0067.v1

Tsygankoite, Mn8Tl8Hg2(Sb21Pb2Tl)Σ24S48, a New Sulfosalt from the Vorontsovskoe Gold Deposit, Northern Urals, Russia

Anatoly V. Kasatkin, Emil Makovicky, Jakub Plášil, Radek Škoda, Atali A. Agakhanov, Vladimir Y. Karpenko, Fabrizio Nestola

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: tsygankoite; new sulfosalt; thallium; crystal structure; Vorontsovskoe gold deposit

Online: 3 May 2018 (11:20:28 CEST)

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Tsygankoite, ideally Mn8Tl8Hg2(Sb21Pb2Tl)Σ24S48, is a new sulfosalt discovered at the Vorontsovskoe gold deposit, Northern Urals, Russia. It occurs as lath-like elongated crystals up to 0.2 mm embedded in calcite-dolomite-clinochlore matrix. The associating minerals also include aktashite, alabandite, arsenopyrite, barite, cinnabar, fluorapatite, orpiment, pyrite, realgar, routhierite, sphalerite, tilasite, titanite, etc. The new mineral is non-fluorescent, black, opaque with a metallic lustre and black streak. It is brittle with an uneven fracture and no obvious parting and cleavage. Its Vickers hardness (VHN10) is 144 kg/mm2 (range 131–167) and its calculated density is 5.450 g cm-3. In reflected light tsygankoite is white; between crossed polars it is dark-grey to black. It is strongly anisotropic: rotation tints vary from light-grey to dark-grey to black. Pleochroism and internal reflections are not observed. The chemical composition of tsygankoite (wt.%, electron-microprobe data) is: Mn 6.29, Fe 0.02, Cu 0.02, Ag 0.01, Hg 5.42, Tl 26.05, Pb 5.84, As 3.39, Sb 30.89, S 21.87, Se 0.01, total 99.81. The empirical formula, calculated on the basis of 90 atoms pfu, is: Mn8.06Tl8.00(Hg1.90Fe0.03Cu0.02Ag0.01)Σ1.96(Sb17.85As3.18Pb1.98Tl0.97)Σ23.98(S48.00Se0.01)Σ48.01. Tsygankoite is monoclinic, space group C2/m, a = 21.362(4) Å, b = 3.8579(10) Å, c = 27.135(4) Å, β= 106.944(14)°, V = 2139.19(17) Å3 and Z = 1. The five strongest diffraction peaks from X-ray powder pattern [listed as (d,Å(I)(hkl)] are: 3.587(100)(112), 3.353(70)(-114), 3.204(88)(405), 2.841(72)(-513) and 2.786(99)(-514). The crystal structure of tsygankoite was refined from single-crystal X-ray diffraction data to R = 0.0607 and consists of an alternation of two thick layer-like arrays, one based on PbS-archetype and second – on SnS-archetype. Tsygankoite has been approved by the IMA-CNMNC under the number 2017-088. It is named for Mikhail V. Tsyganko, mineral collector from Northern Urals, who collected the samples where the new mineral was discovered.

Preprint ARTICLE | doi:10.20944/preprints201804.0381.v1

An Overview of Hand held Sun Photometer Measurements of Atmospheric Aerosols in New Orleans, Louisiana: A case study of the Xavier University Study Site

Maryssa Bradley, Barry Sevalia, Morewell Gaseller

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Sun photometer, Aerosols, Aerosol Optical Depth (AOT), New Orleans

Online: 30 April 2018 (12:28:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1085.v1

Preparation and hydration properties of sodium silicate-activated municipal solid waste incineration bottom ash composite slag cementitious materials

Juan Deng, Guoxiong Wu, Yuchao Xia, Li Liu

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: MSWIBA, sodium silicate-activated, hydration properties, equivalent age modeling

Online: 17 April 2024 (08:06:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0025.v1

Analysis of the Evolution of Water Quality in Tanks according to the Connections and Operation Mode. Application to the most Suitable Design

Marta Hervás, Fernando Martínez-Alzamora, Pilar Conejos

Subject: Engineering, Civil Engineering Keywords: Simulation; water quality; water age; storage tanks; hydraulic networks

Online: 1 April 2024 (10:33:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.1332.v1

Influence of the Age of Free-Living Amoeba Cysts on Their Vertical Distribution in a Water Column

Zineb Fechtali-Moute, Sébastien Pomel

Subject: Biology And Life Sciences, Life Sciences Keywords: Free-Living Amoeba; cyst; age; water column; vertical distribution

Online: 17 January 2024 (13:38:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0040.v1

Discrete-time Survival Models with Neural Networks for Age-Period-Cohort Analysis of Credit Risk

Hao Wang, Anthony Graham Bellotti, Rong Qu, Ruibin Bai

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Credit risk; Survival model; Neural network; Age-Period-Cohort

Online: 3 January 2024 (03:53:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0166.v1

Knowledge Representation of Age-Related Diseases under Innate and Adaptative-Immunosenescence Valued Contexts

javier Burgos-Salcedo

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Immunosenescence; Knowledge representation; Formal concept Analysis; Age-related diseases

Online: 4 December 2023 (11:27:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1534.v1

Mitigating Age-related Bias in Predictive Policing Algorithms

Ahmed Saud Almasoud

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: predictive policing; algorithms; fairness; age bias; strategic subject list

Online: 24 November 2023 (02:42:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1581.v1

Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily

Miriam Carella, Annamaria Porreca, Cinzia Piazza, Francesco Gervasi, Daniele Magro, Marika Venezia, Raffaella Lo verso, Giuseppe Vitale, Anna giusy Agnello, Tommaso Aronica, Carmela Rita Balistreri

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: renal age-related decline; kidney disease (KD); eGFR; mGPS

Online: 25 October 2023 (08:35:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1249.v1

The Relationship between Jealousy and Mate Retention Strategies in Romantic Relationships among Women during the COVID-19 Pandemic

Paulina Degiuli, Lea Andreis, Dario Vučenović

Subject: Social Sciences, Psychology Keywords: jealousy; partner retention strategies; romantic relationship; age; relationship length

Online: 20 October 2023 (08:06:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0658.v2

Assessment of Knowledge and Attitude of Reproductive Age Women towards Cervical Cancer Prevention in Selected Tertiary Institutions in Osun State, Nigeria

Oluwabunmi B. Erinsakin, Adeyemi O. Omoge, Oladunni Opeyemi, Idowu A. Olumakinde, Busayomi E. Folashayo, Michael N. Philip

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Knowledge; Attitude; Women of Reproductive Age; Cervical Cancer Prevention

Online: 17 October 2023 (11:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1322.v1

Age and Task Modulate Olfactory Sensitivity in the Florida Carpenter Ant Camponotus floridanus

Stephen T Ferguson, Isaac Bakis, Nicholas D Edwards, Laurence J Zwiebel

Subject: Biology And Life Sciences, Insect Science Keywords: hymenoptera; olfaction; odor coding; task allocation; age polyethism; aging

Online: 19 July 2023 (10:03:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0469.v1

Dynamical Analysis of an Age-Structured Sveir Model With Imperfect Vaccine

Yanshu Wang, Hailiang Zhang

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: SVEIR model; latent age; imperfect vaccine; Lyapunov functions; stability

Online: 7 June 2023 (02:32:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0832.v1

Age of Onset Moderates the Association Between Total Antioxi-Dant Capacity and Cognitive Deficits in Patients With Drug-Naïve Schizophrenia

Jiaxin Li, Deyang Li, Junru Guo, Dongmei Wang, Xiangyang Zhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; age of onset; TAOC; cognitive function; oxidative stress

Online: 24 April 2023 (06:22:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0350.v2

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

Laura García-Quintanilla, Lorena Rodríguez-Martínez, Enrique Bandín-Vilar, María Gil-Martinez, Miguel González-Barcia, Cristina Mondelo-García, Anxo Fernández-Ferreiro, Jesús Mateos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Proteomics, Age-related macular degeneration, inflammation, biomarker, oxidative stress.

Online: 21 November 2022 (02:35:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0278.v1

Association between Knowledge about Anemia, Food Consumption Behaviors, and Hematocrit Level among School-Age Children in Nakhon Si Thammarat Province, Thailand

Pastraporn Kaewpawong, Kiatkamjorn Kusol, Onuma Bunkarn, Sirigran Sutthisompohn

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: knowledge; food consumption behaviors; hematocrit level; school-age children

Online: 19 October 2022 (10:06:28 CEST)

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Anemia is a significant public health problem among children, especially school-age children because their body quickly produces red blood cells to provide sufficient blood volume with plasma expansion to maintain blood concentration. This research aimed to study the anemia situation, knowledge about anemia, food consumption behaviors, and the association between knowledge, food consumption behaviors, and hematocrit level among school-age children in primary school, in Thasala district, Nakhon Si Thammarat Province. This is a descriptive study among 408 students, Grades 4 to 6, aged 9-12 years. Research instruments included the demographic data of the children and their knowledge about anemia, food consumption behaviors, and hematocrit assessment. Data were analyzed using descriptive, Spearman’s rank correlation coefficient, and logistic regression statistics. The results revealed that 23.2% of the samples had anemia, whereas 22.22% had mild anemia and 0.98% had moderate anemia. The children knew about anemia, where the mean score was at a moderate level (Mean= 6.63; SD= 2.51) out of 10. The mean score on food consumption behaviors was in the moderate level (Mean= 17.49; SD= 3.68) out of 24. There were significantly positive correlations between the knowledge about anemia and the hematocrit level at a moderate level (r= 0.45, p< 0.001). Correlation analysis revealed moderate food consumption behaviors with the hematocrit level (r= 0.40, p< 0.001). When confirm with Logistic regression found that knowledge about anemia (OR = 9.15, 95% CI: 4.57-18.34), and food consumption behaviors (OR = 19.09, 95% CI: 9.71-37.53) were significantly associated with the hematocrit level. Conclusions: This study showed that knowledge and appropriate food consumption behaviors are associated with hematocrit levels. Enhancing knowledge about anemia and food consumption behaviors may be reduced the prevalence of anemia in school-age children. The health care providers in primary care should be encouraged children to have health education and eat sufficient food.

Preprint ARTICLE | doi:10.20944/preprints202206.0091.v1

Assessing the Effectiveness of Tobacco 21 Laws to Reduce Underage Access to Tobacco: Protocol for a Repeated Multi-Site Study

Mary Hrywna, Amanda Kong, Christopher Ackerman, Shawna Hudson, Cristine Delnevo

Subject: Public Health And Healthcare, Health Policy And Services Keywords: tobacco age of sale; tobacco policy; youth; young adults

Online: 7 June 2022 (03:44:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0367.v1

Differences in Citation Patterns across Areas, Article Types and Age Groups of Researchers

Marcelo Mendoza

Subject: Social Sciences, Library And Information Sciences Keywords: Citation patterns; Age groups of researchers; Types of publications.

Online: 17 August 2021 (15:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0729.v1

Sergey Sudakov, Elena Alekseeva, Galina Nazarova, Valentina Bashkatova

Subject: Social Sciences, Psychology Keywords: age; behaviour; open field; physical activity; anxiety; Wistar rat.

Online: 30 June 2021 (10:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0536.v1

“What a Mobility-Limited World”: Design Requirements of an Age-Friendly Playable City

Liliana Vale Costa, Ana Isabel Veloso, Michael Loizou, Sylvester Arnab, Richard Tomlins, Arun Sukumar

Subject: Social Sciences, Urban Studies And Planning Keywords: playable city; age-friendly environments; games; mobility; active ageing

Online: 23 October 2018 (10:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0111.v1

Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations

Jacqueline R. Halladay, Kaitlin C. Lenhart, Kimberly Robasky, Wendell Jones, Wayne F. Homan, Doyle M. Cummings, Crystal W. Cené, Alan L. Hinderliter, Cassandra L. Miller, Katrina E. Donahue, Beverly A. Garcia, Thomas C. Keyserling, Alice S. Ammerman, Cam Patterson, Darren A. DeWalt, Larry F. Johnston, Monte S. Willis, Jonathan C. Schisler

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: hypertension; GWAS; precision medicine; rural population; SNP-age interaction

Online: 12 January 2018 (07:34:37 CET)

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Background: As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: i) determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure variation, identified in large case-control studies, are applicable to blood pressure control in subjects from a rural population; ii) measure the association of these SNPs with subjects’ responsiveness to the hypertension intervention; and iii) identify other SNPs that may help understand patient-specific responses to an intervention. Methods and Results: We used a combination of candidate SNPs and genome-wide analyses to test associations with either baseline systolic blood pressure (SBP) or change in systolic blood pressure one year after the intervention in two genetically defined ancestral groups: African Americans (AA) or Caucasian Americans (CAU). Of the 48 candidate SNPs, 13 SNPs associated with baseline SBP in our study; however, one candidate SNP, rs592582, also associated with a change in SBP after one year. Using our study data, we identified 4 and 15 additional loci that associated with a change in SBP in the AA and CAU groups, respectively. Our analysis of gene-age interactions identified genotypes associated with SBP improvement within different age groups of our populations. Moreover, our integrative analysis identified AQP4-AS1 and PADI2 as genes whose expression levels may contribute to the pleiotropy of complex traits involved in cardiovascular health and blood pressure regulation in response to an intervention targeting hypertension. Conclusions: Identification of SNPs associated with the success of a hypertension treatment intervention suggests that genetic factors in combination with age may contribute to an individual’s success in lowering SBP. If these findings prove to be applicable to other populations, the use of this genetic variation in making patient-specific interventions may help providers with making decisions to improve patient outcomes. Further investigation is required to determine the role of this genetic variance with respect to the management of hypertension such that more precise treatment recommendations may be made in the future as part of personalized medicine.

Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1497.v1

Adoption of Fourth Industrial Revolution Technologies in the Construction Sector: Evidence from a Developing Country

Julia Menegon-Lopes, Luiz Carlos Pinto da Silva Filho

Subject: Architecture, Building And Construction, Engineering Keywords: Industry 4.0; Construction 4.0; New technology; Digital transformation; Developing country

Online: 23 April 2024 (11:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1382.v1

Identification and Pathogenicity of Pestalotioid Species on Alpinia oxyphylla in Hainan Province, China

Xiufen Cui, Zhigang Hao, Menghuai Chen, Shuang Song, Jinan Zhang, Yingbin Li, Jianqiang Li, Yixiang Liu, Laixin Luo

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: Pestalotioid species; New taxa; Alpinia oxyphylla; Ring leaf blight; Pathogenicity

Online: 22 April 2024 (10:16:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0672.v1

Integrating Contemporary Technologies in Education: Empowering Youth for Sustainable Future through New Literacies

Dejan Zemljak, Daniel Hari, Matevž Bratina, Andrej Flogie, Boris Aberšek, Maja Kerneža

Subject: Social Sciences, Education Keywords: contemporary technology; education; empowering youth; humanoid robots; new literacies; sustainability

Online: 12 March 2024 (10:25:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0172.v1

Explore the Legal Challenges and Coping Strategies for the Development of New Biomedical Technologies

Zhangsheng Sun, Xinyan Li

Subject: Biology And Life Sciences, Other Keywords: ; biomedical ethics; New biomedical technologies; Legal challenges; Coping strategies

Online: 4 March 2024 (14:06:22 CET)

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New biomedical technologies are examined in depth and the legal and ethical challenges they pose. Key issues such as gene editing, the application of artificial intelligence in the medical field, and the protection of biological information data are analyzed. At the same time, we also found that technological advances in the development of the enormous potential of biomedicine, but also raises a series of ethical and legal issues. To this end, the paper proposes a series of effective response strategies aimed at providing guidance to policy makers, researchers, and healthcare professionals to ensure the rational and safe application of new technologies. Solutions to these challenges are elaborated. When it comes to gene editing, the article stresses the responsibility of scientists not only to push the boundaries of technology, but also to ensure that edited genes are in the public interest and respect individual rights. To this end, strict regulatory mechanisms should be put in place to ensure that gene editing is carried out only in certain and ethical circumstances. Although AI technology has brought many conveniences to the medical field, it also involves data privacy protection, the transparency of the AI decision-making process, and the impact of AI on traditional medical models. Therefore, it is necessary to formulate corresponding regulations to regulate its application, ensure the fairness and transparency of AI decision-making, and promote its integration and development with traditional medicine. The importance of the protection of biometric data was also emphasized. In biomedical research, a large number of personal biological information data, such as genome and proteome, are often involved. This data should be effectively protected to prevent data leakage and misuse. To this end, it is necessary to strengthen data security measures and establish standards and norms for data sharing and utilization to ensure the rational use and protection of data.

Preprint ARTICLE | doi:10.20944/preprints202402.1034.v1

Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1)

Zsolt Abonyi-Tóth, György Rokszin, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, Gergő A. Molnár, Gábor Sütő

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 diabetes mellitus; epidemiology; cancer; incidence; new-onset diabetes

Online: 19 February 2024 (10:20:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1592.v1

Dualistic effects of PRKAR1A as A Potential Anticancer Target in Cancer Cells and Cancer-Derived Stem Cells

Joong-Won Baek, A-Reum Nam, Kyung-gon Kim, Pyung-Hwan Kim

Subject: Biology And Life Sciences, Life Sciences Keywords: Cancer; Cancer Stem Cells; Proteomic analysis; New Biomarkers; Dualistic effect

Online: 23 January 2024 (00:05:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0274.v1

A Novel Index of Agricultural Drought Measurement: Soil Moisture and Evapotranspiration Revealed Drought Index (SERDI)

hushiar hamarash, Azad RASUL, Rahel HAMAD

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Evapotranspiration; New Drought Index; Semi-arid Areas; Soil Moisture; TerraClimate

Online: 5 November 2023 (17:16:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0966.v1

Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review

Francesco Orsini, Chiara Crotti, Gilberto Cincinelli, Raffaele Di Taranto, Andrea Amati, Matteo Ferrito, Massimo Varenna, Roberto Caporali

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: osteoimmunology; rheumatoid arthritis; erosions; spondyloarthritis; bone tissue; new bone formation

Online: 14 September 2023 (08:23:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0203.v1

A New Model for IT Management in the Digital Era

Martin Wynn, Kerstin Felser

Subject: Business, Economics And Management, Business And Management Keywords: digitalization; IT management; German automotive industry; new model; digital transformation

Online: 5 September 2023 (03:10:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.2059.v1

Tackling Drug-Resistant Tuberculosis: New Challenges from the Old Pathogen Mycobacterium tuberculosis

Giuseppe Mancuso, Angelina Midiri, Silvia De Gaetano, Elena Ponzo, Carmelo Biondo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: M.tb pathogenesis; MDR-TB; XDR-TB; drug tolerance; new approaches

Online: 30 August 2023 (11:20:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1791.v1

Super Strong Gravitational Field and New Theory of Gravity

yin zhu

Subject: Physical Sciences, Theoretical Physics Keywords: Gravitational field; New theory of gravity; Orbit; Graviton-photon interaction

Online: 26 July 2023 (09:47:43 CEST)

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Preprint ESSAY | doi:10.20944/preprints202307.1076.v1

Book Review in Political Geography: Rereading “The New Map” by Daniel Yergin

Young-Jin Ahn, Zuhriddin Juraev

Subject: Social Sciences, Geography, Planning And Development Keywords: Global energy landscape; Geopolitical implications; New map; Political geography; Review

Online: 17 July 2023 (08:14:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1515.v1

Additions to the Genus Helicosporium (Tubeufiaceae, Tubeufiales) from China with an Identification Key to Helicosporium Taxa

Xing-Juan Xiao, Jian Ma, Li-Juan Zhang, Ning-Guo Liu, Yuan-Pin Xiao, Xing-Guo Tian, Zong-Long Luo, Yong-Zhong Lu

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: 6 new taxa; ascomycetes; asexual morph; filamentous fungi; phylogeny; taxonomy

Online: 21 June 2023 (09:44:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1000.v1

A Novel Caffeine Oleate Formulation as an Insecticide to Control Coffee Berry Borer, Hypothenemus hampei, and Other Coffee Pests

Carmenza E. Góngora, Johanna Tapias, Jorge Jaramillo, Rubén Medina, Sebastián González, Tatiana Restrepo, Herley Casanova, Pablo Benavides

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Coffee berry borer; caffeine; oleic acid, kaolin; new insecticide, infestation.

Online: 15 May 2023 (07:59:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0631.v1

Ergogenic Effects of the Combination of Caffeine and New Zealand Blackcurrant Supplements: A Double-Blind Singe-Case Experimental Study

Sebastian Zart, Carlo Dindorf, Michael Fröhlich

Subject: Social Sciences, Other Keywords: caffeine; New Zealand blackcurrant; anthocyanins; ergogenic; supplement; performance; endurance; sports

Online: 20 April 2023 (08:25:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0054.v1

Exploring the Interplay of New Energy Vehicle Enterprises, Consumers, and Government in the Context of the 'Dual Carbon' Target: An Evolutionary Game and Simulation Analysis

Rui Song, Xingjian Xue, Wanyi Qin, Wen Shi

Subject: Engineering, Energy And Fuel Technology Keywords: new energy vehicles; “dual carbon” targets; evolutionary games; government subsidies

Online: 5 April 2023 (10:15:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0355.v1

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates

Surbhi Jain, Utkarsha Sahu, Awanish Kumar, Prashant Khare

Subject: Biology And Life Sciences, Parasitology Keywords: Leishmania; Human Pathogen; Targeting Metabolic Pathways; Repurposed Drugs; New Antileishmanials.

Online: 27 June 2022 (08:47:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0071.v2

Trends of Treatment Development in Rheumatoid Arthritis: Promise, Progress, and Challenges

Ping Jiang, Kai Wei, Jianan Zhao, Yehua Jin, Cen Chang, Runrun Zhang, Lingxia Xu, Linshuai Xu, Yiming Shi, Shicheng Guo, Steven J. Schrodi, Dongyi He

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: rheumatoid arthritis; precision medicine; new treatment; drug development; method development

Online: 25 May 2022 (04:59:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0399.v1

Implementation of Clinical Assistants in a Pediatric Oncology Department: an Activity and Clinical Time Release Analysis

Cristina Adroher, Celia Calvo, Laura Pavon, Ricard Casadevall, Esther Alvarez, Mariona Marsal, Francesc Lopez, Andres Morales La Madrid

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: clinical assistants; pediatric oncology; assistance activity; new roles; skill mix

Online: 22 November 2021 (14:00:03 CET)

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Background: There is a high bureaucratic and administrative burden associated with health care tasks (test requesting, visits scheduling, supporting documents provision) that has historically largely fallen on health care professionals, which is one among the factors contributing to low job satisfaction and lower productivity. Incorporating new professional roles that help to better respond to the needs of both patients and professionals can increase the quality and efficiency of service provision. Objective: To evaluate the impact of the clinical assistant’s introduction in the Sant Joan de Déu Barcelona Children’s Hospital’s pediatric oncology department, in terms of displacement of activity loads carried out by this new professional role and the consequent time freed up for physicians. Methodology: Observational and retrospective study using administrative data based on the analysis of the type of activity performed by clinical assistants and the measurement of the time freed up in favor of the physicians, based on in situ timekeeping, to approximate the potential skill mix productivity increase. Results: Since its implementation in the pediatric oncology department, clinical assistants have performed 13,553 requests (69.93% of the total), representing a total saving of 266.83 hours or 6.67 workweeks of 40 hours. They performed 74.25% of outpatient surgical requests in the oncology department, 87.5% of day hospital requests and 54.13% of total requests in the outpatient consultations area. Conclusion: The introduction of clinical assistants in the oncology department could be efficient to the extent that it displaces a good part of the bureaucratic and administrative tasks previously performed by health care professionals. This delegation allows them to work more closely to the maximum of their competences and the physicians to have more time for higher added value clinical tasks. In terms of efficiency, this role change enables to optimize the clinical process, reducing the cost by 56% compared to the conventional model.

Preprint ARTICLE | doi:10.20944/preprints202106.0258.v1

An appraisal of the Filipino Catholic Devotion to the Black Nazarene in the light of New Evangelization

Joseph Albert Reyes

Subject: Social Sciences, Anthropology Keywords: Black Nazarene; Popular Devotion; Filipino Catholics; Sacred Liturgy; New Evangelization

Online: 9 June 2021 (11:10:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0078.v1

New Governance Through Digital Platforms and the Old Urban Planning Process in Italy

Cinzia Bellone, Fabio Naselli, Fabio Andreassi

Subject: Social Sciences, Anthropology Keywords: Urban planning Italy; Governance 3.0; New Digital Platforms; Sentiment Analysis

Online: 6 May 2021 (12:27:35 CEST)

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Preprint BRIEF REPORT | doi:10.3390/sci2030055

Coronavirus Disease (COVID-19): Handling Challenges in Kuwait

Janvier Gasana, Maryam Shehab

Subject: Public Health And Healthcare, Health Policy And Services Keywords: coronavirus; COVID-19; 2019-nCoV; novel (new) coronavirus; pandemic control

Online: 14 July 2020 (00:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0187.v1

Exploratory Factors Influencing Building Development Costs in New Zealand Using SEM

Linlin Zhao, Jasper Mbachu, Niluka Domingo

Subject: Engineering, Control And Systems Engineering Keywords: influencing factors; building development costs; New Zealand; structural equation modeling

Online: 28 April 2017 (05:22:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0189.v1

The Global Burden of Type 2 Diabetes Attributable to Dietary Risks: Insights from the Global Burden of Disease Study 2019

Alina Ioana Forray, Mădălina Adina Coman, Ruxandra Simonescu-Colan, Andreea Isabela Mazga, Răzvan Mircea Cherecheș, Cristina Maria Borzan

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: type 2 diabetes mellitus; Global Burden of Disease Study; dietary risk factors; Age- Standardized Mortality Rate; Age-Standardized DALY Rate; Socio-Demographic Index

Online: 4 October 2023 (04:55:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0257.v1

Generation System for Renewable Energy Density Substantially Higher than that of Power Stations and Presentation of Novel Superconductivity

Shinichi Ishiguri

Subject: Physical Sciences, Condensed Matter Physics Keywords: divergent current density; new superconductivity; Meissner effect; new type of condensation; energy generation; electrostatic potential; independent current source; voltage-controlled current source; renewable energy

Online: 16 March 2020 (04:18:23 CET)

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Societies around the world face serious energy problems related to the consumption of fossil fuels and the emission of dangerous radiation. To solve these problems, a new superconductor exhibiting a critical temperature higher than room temperature has been pursued but not achieved. This paper proposes a new energy generation system based on a circuit approach. Secondary to this process, a new type of superconductivity without refrigeration is demonstrated. In our previous paper [1], this system was proposed, but it did not describe the underlying theory in detail and did not mention an actual method to generate energy from the system. The present paper describes the theory of the existence of divergent current density and new superconductivity with no refrigeration. Moreover, the present paper proposes a method for extracting energy from the system by employing a voltage-controlled current source (i.e., a voltage–current converting method).The principle of the system is based on a circuit of two loops and independent current sources. First, the two electric loops are prepared, each with 4 diodes, where the diodes are oriented in the same direction within each loop, but their direction is opposite from loop to loop; four independent current sources connect the loops. In this circuit system, current is added iteratively as it flows along the loop according to Kirchhoff’s circuit law. As a result, a large current and electric potential are present along the loop. To confirm that this system works properly, it is necessary to demonstrate the presence of divergent currents in the transient state, and to do this, the present paper employs the Dirac equation and Lorentz conservation. Electric circuit software is employed to demonstrate that the presented method generates energy actually from our system.Our results confirm the presence of divergent current at a connected point of an independent current source in the transient state. Moreover, in the steady state, the theory demonstrates the Meissner effect (i.e., a London equation) and a new type of macroscopic wave function and condensation. For an initial small input current of 0.1 μA, the simulation reveals a large generating current of 7 kA and electric power of 10¹¹ W, which is much larger than unit of power from an average thermal power station; moreover, the system presents with superconducting electrical transport conditions.The present study is significant because it demonstrates theoretically the existence of divergent current density and a new type of superconductivity requiring no refrigeration. Secondly, the simulations show the generation of a large energy density that can be obtained in a small laboratory room with minimal cost.

Preprint ARTICLE | doi:10.20944/preprints202404.0774.v1

Junxia Li, Zhenguo Wang, Liujia Wang, Xiayuan Wang, Dong He, Xinming Duan, Chunxiang Zhang, Youshe Ren, Chunhe Yang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: cashmere goat; cashmere production; secondary hair follicle; age; oxidative stress

Online: 11 April 2024 (10:12:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1497.v1

Ethnic Representation Matters: Investigating Bias in Facial Age Prediction Models

Nenad Panić, Marina Marjanović, Timea Bezdan

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Facial recognition; Age prediction; Convolutional Neural Network (CNN); Ethnicity bias

Online: 26 March 2024 (08:15:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0998.v1

Development and Implementation of Virtual Reality Application: Age-Friendly Health System Scenario

Sweta Tewary, Oksana Shnayder, Marie Dezine, Naushira Pandya

Subject: Public Health And Healthcare, Primary Health Care Keywords: virtual reality; age friendly health systems; medical education; older adults

Online: 19 February 2024 (15:45:44 CET)

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INTRODUCTION: With an increase in the aging population, the application of evidence-based practice in geriatric education can strengthen knowledge, skills, and clinical experience for healthcare students caring for older adults. Age Friendly Health Systems (AFHS) is one of the frameworks founded on providing evidence-based and low-risk care centered on what matters most to older adults, their families, and caregivers. Virtual Reality (VR) platforms are gaining popularity due to their ability to provide an immersive, hands-on learning experience resembling an actual medical practice or care setting. Immersive learning enhances students’ sensory perceptions, promoting an innovative and engaging way of acquiring concepts that are difficult to teach in real life. This study aimed to design, develop, implement, and evaluate a case-based training module highlighting AFHS and educating medical students on the 4Ms approach in geriatric care (What Matters, Medication, Mentation, and Mobility). METHODOLOGY: The project was a feasibility study completed in two phases. Phase one included planning and development of a case-based scenario incorporating 4Ms of AFHS. Phase two included implementing and evaluating the VR training module into the geriatric curriculum for medical students. RESULTS: The final VR case displays a hospital and post-acute setting where an elderly patient is admitted for a hip fracture. Students learn how to triage and treat patients from admission to discharge while demonstrating their knowledge of AFHS. Approximately 10% of students completed the evaluation survey, and preliminary results indicate significant knowledge change in pre-post scenario-based training on AFHS. CONCLUSION: The VR education platform and embedded scenario promise an innovative adaptation of technology in learning the concepts of the 4Ms of AFHS. However, future studies should explore VR education with clinical assessment evaluation to ensure competence in providing Age-Friendly care.

Preprint REVIEW | doi:10.20944/preprints202402.1022.v1

The Value of Autopsy in the Modern Age: Discrepancy between Clinical and Autopsy Diagnoses

Cecilia Salzillo, Roberta Basile, Gerardo Cazzato, Giuseppe Ingravallo, Andrea Marzullo

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: hospital autopsy; modern age; clinical diagnosis; autopsy diagnosis; Public Health

Online: 19 February 2024 (08:22:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1799.v1

Suboptimal Nutritional Status of School-Age Children in Addis Ababa: Evidence from the Analysis of Sociodemographic, Environmental, and Behavioral Factors

Yimer Mihretie Mihretie, Abebe Ayelign, Tadesse Alemu Zerfu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: ; Addis Ababa; dietary factors; nutritional status; school-age children

Online: 25 January 2024 (09:53:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0350.v1

Human Age Estimation from Face Images with Deep Convolutional Neural Networks Using Transfer Learning

Gilbert George, Chandrashekhar Uppin, Usman Abubakar Bello

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Convolution neural network; Deep Learning; Facial Age; Regression; Transfer learning

Online: 4 January 2024 (07:41:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1081.v1

Splenic Stiffness Measured by 3-Tesla Magnetic Resonance Elastography Is Correlated with Age in Healthy Individuals

Süheyl Poçan, Levent Karakaş

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: 3 tesla magnetic resonance; age, healty volunteers; elastography; splenic stiffness

Online: 17 October 2023 (11:20:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1069.v1

Splenic Stiffness Measured by 3-Tesla Magnetic Resonance Elastography Is Correlated with Age in Healthy Individuals

Süheyl Poçan, Levent Karakaş

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: 3 tesla magnetic resonance; age; healty volunteers; elastography; splenic stiffness

Online: 17 October 2023 (11:11:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0861.v1

Pattern of Presentation and Risk Factor Prediction of Acute Myocardial Infarction in Kosovo

Afrim Poniku, Arlind Batalli, Dua Shita, Zarife Rexhaj, Arlind Ferati, Rita Leka, Artan Bajraktari, Genc Abdyli, Edmond Haliti, Pranvera Ibrahimi, Shpend Elezi, Faik Shatri, Ibadete Bytyçi, Michael Henein, Gani Bajraktari

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myocardial infarction; risk factors; smoking; diabetes; arterial hypertension; age; gender

Online: 14 September 2023 (02:34:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0670.v1

Precision and Accuracy of Radiological Bone Age Assessment in Children among Ethnical Groups

Sebastián Eustaquio Martín Pérez, Isidro Miguel Martín Pérez, Jesús Vega González, Ruth Molina Suárez, Coromoto León Hernández, Fidel Rodríguez Hernández, Mario Ulises Herrera Perez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: diagnostic imaging; radiography; age determination by skeleton; racial group; children

Online: 11 September 2023 (11:11:23 CEST)

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Introduction: Determination of radiological bone age (BA) is a diagnostic method that consists of estimating chronological age (CA) from the bone maturation of children. Although environmental and hormonal factors can interfere with bone ossification, the process is essentially dependent on ancestral inheritance. These ethnic backgrounds are not usually considered, which can lead to biased interpretations and inadequate decision-making by pediatricians or forensic experts. The objective of this study was to determine the precision and accuracy of these radiological procedures among different ethnic groups. Methods: A qualitative systematic review carried out following MOOSE statement and previously registered in the International Prospective Registry of Systematic Reviews PROSPERO (CRD42023449512). Search was performed in MEDLINE (PubMed) (n=561), Cochrane Library (n=261), CINAHL (n=103), Web of Science (WOS) (n=181) and public institutional repositories (n=37) from inception to 31st December 2022 using Mesh as “Diagnostic Techniques and Procedures”, “Diagnostic imaging”, “Radiography”, “Age Determination by Skeleton” and free terms combining with booleans “AND” and “OR”. PEDro scale, and Risk of Bias in non-randomized Studies of Exposure (ROBINS-E) were used to assess methodological quality and risk of bias of included studies respectively. Results: 51 articles (n=19,531) were included according to the inclusion criteria previously established. There was a good to moderate methodological quality and a high to very high risk of bias. Skeletal methods for determining BA were precised in terms of intra-observer and inter-observer reliability in all ethnic groups. Regarding to accuracy of Skeletal methods in Caucasians and Hispanic children, GPA was accurate at all ages, but in youths, TW3 RUS could be a consistent alternative. In Asian and Arab, GPA and TW3 overestimated BA in adolescents near adulthood. In African youths, GPA overestimated BA while TW3 was more accurate in estimating CA. Dental and Cervical radiographic methods are equally precise but lesser accurate than Skeletal BA determination. Conclusion: Skeletal radiographic methods GPA and TW3 are both precise for BA determination among all ethnical groups, but their accuracy in estimating CA can be altered by racial bias.

Preprint ARTICLE | doi:10.20944/preprints202306.0653.v1

Determinants of Child Nutritional Status among Scheduled Tribes in West Bengal

Manabindra Barman, Dr. Indrajit Roy Chowdhury

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Scheduled tribe; Children; Nutritional status; Under 5years age; Determinant factors

Online: 9 June 2023 (03:04:37 CEST)

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Malnutrition is the main cause of child mortality in developing nations, especially in Sub-Saharan Africa and South Asian countries. This undernutrition status is predominantly higher among primitive tribal (ST) children under 5 years of age. The nutritional status of tribal children is a serious concern in India. For this, there should be intends to examine the prevalence and determinants of primitive tribal children's nutritional status. To investigate the effect of household, child’s & maternal characteristics on biological children under 5 years of age. The study aims to find out the association between some selected determinants on scheduled tribe child’s nutritional status. The study used some selected variable of scheduled tribe mothers, household characteristics and their children anthropometric indices from DHS datasets of India, which was published by the NFHS datasets of India. In this study People datasets and Children (Under 5 years of age) of interviewed women file datasets of NFHS-IV & V is taken. The datasets of West Bengal, ST mothers, and their child into consideration as per the research interest. Then to analyze the determinants of ST children (U5 age) nutritional status, some determinant factors are taken from mothers, children and household characteristics. Children’s stunting, wasting and underweight as dependent variable and the mothers, child’s and household’s characteristics as independent variable. The statistical analysis was done by using Pearson Chi square test used to analyze the association between dependent and independent variables. The study results shows that the mother’s educational status, child’s age, birth order, size of child at birth, type of residence had significant associations with stunting. Mother's anemia status and mother age had significant associations with wasting. Mother education, currently breastfeeding, child age, sex of the child, birth order, size of child at birth, type of residence, wealth, toilet facility, and cooking fuel shows a significant association with underweight. The results found that many determinant factors had a significant role among ST children's (U5 age) nutritional status. Thus, the findings will help to achieve tentative resource allocation, and utilization through various programs and policies to improve the ST children (U5 age) nutritional status. There is a need to take a multisectoral and multidimensional approach to develop for those primitive tribal children.

Preprint ARTICLE | doi:10.20944/preprints202305.1011.v1

Prevalence of Vitamin B₁₂ and Folate Deficiencies in Indian Children and Adolescents

Tattari Shalini, Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, Hemalatha Rajkumar, Harshpal S Sachdev, Anura V Kurpad, Geereddy Bhanuprakash Reddy

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Vitamin B12 deficiency; Folate deficiency; School-age children; Adolescents; CNNS

Online: 15 May 2023 (09:45:12 CEST)

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Deficiencies of vitamin B12 (B12) and folate (FA) are of particular interest due to their pleiotropic role in 1-carbon metabolism. In addition to adverse birth outcomes, deficiencies of B12 and FA, or an imbalance in FA/B12 status, are linked to metabolic disorders. Indian diets that are predominantly plant food-based could be deficient in these vitamins, but there are no national estimates of the prevalence of B12 and FA deficiency in Indian children and adolescents, nor of their associations with age, sex, and growth indicators. The recent Comprehensive National Nutrition Survey (CNNS-2016-18) provided estimates of the prevalence of B12 and FA deficiency at the national and state level among preschool (1-4y: 9,976 and 11,004 children respectively), school-age children (5-9y: 12,156 and 14,125) and adolescents (10-19y: 11,748 and 13,621). Serum B12 and erythrocyte FA were measured by the direct chemiluminescence method and their deficiency was defined using WHO cut-offs. The prevalence of B12 and FA deficiency was high among adolescents (31.0%, CI: 28.7-33.5 and 35.6%, CI: 33.1-8.2), compared to school-age (17.3%, CI: 15.4-19.3 and 27.6%, CI: 25.5-29.9) and preschool children (13.8%, CI: 11.7-16.2 and 22.8%, CI: 20.5-25.2, respectively). The prevalence of both B12 and FA deficiency was significantly higher by 8 and 5% points respectively, in adolescent boys compared to girls. The prevalence of B12 deficiency was higher in moderately stunted school children (by 18.9% points) than in normal children, but no such difference was observed for FA deficiency. There was wide regional variation in the prevalence of B12 and FA deficiency, but no rural-urban differences were observed across all age groups. The national prevalence of B12 deficiency among preschool or school-age children was <20% (the cut-off that indicates a public health problem). However, FA deficiency in these age groups and both FA and B12 deficiencies in adolescents were >20%, which warrants further investigation.

Preprint ARTICLE | doi:10.20944/preprints202305.0165.v1

Computed Tomographic Features of Thymus Gland in Dogs: Correlation with Age, Gender, Breed and Body Fat Content

Mohammad Molazem, Sarang Soroori, Alireza Bahonar, Saghar Karimi

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Computed tomography, Thymus Gland, Dog, Age, Gender, Breed, Body Fat

Online: 4 May 2023 (02:59:54 CEST)

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: Background: The thymus gland is the first lymphoid organ formed to regulate a newborn's immunity. It reaches its maximum size during puberty, after which it undergoes an atrophic procedure called involution, but its ability to grow again in response to some stresses, such as infections, neoplasia, surgeries, chemotherapy, and radiotherapy is maintained. There is not any comprehensive study on computed tomographic features of thymus gland in dogs. So, the goal of the present study is to achieve some information about thymus gland using computed tomography as a non-invasive method. Methods: One hundred and fifty dogs classified in 5 age groups and 2 breed groups were entered to this study and the thymus gland was evaluated using 2-slice computed tomography machine. The inclusion criteria for the present study were having normal complete blood count, plain and post-contrast CT scan examination of thoracic region and no history of neoplasia, chemotherapy or radiotherapy. The visibility, density, enhancement, grade, size, volume, shape, borders and lateralization of the thymus were evaluated and statistical analysis were performed. The effect of obesity on thymic grade and volume were also investigated. Results: The visibility, density, dorsal length, volume and grade decreased with increasing age. The thymic shape and lateralization were mostly wedge-shaped and left sided respectively. The borders became concave with aging and increasing body fat content caused to increase fatty degeneration of thymus. Conclusions: Declining of thymic density, grade, size and volume with aging was related to thymic involution and fatty degeneration was accelerated by increasing body fat content. Females and Males were different only in thymic shape and small and large breeds were different only in thymic volume. The thymus was visible in some geriatric dogs with no underlying disease. We hope that the present work can be used by radiologists in reading thoracic computed tomography but investigation of thymic characteristics in dogs with neoplasia and history of chemotherapy, radiotherapy and thoracic surgeries can complete this study.

Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0192.v1

Inequalities in Temporal Effects on Cervical Cancer Mortality in States in Different Geographic Regions of Brazil: An Ecological Study

Karina Cardoso Meira, Carinne Magnago, Angelo Braga Mendonça, Stephane Fernanda Soares Duarte, Pedro Henrique Oliveira de Freitas, Juliano dos Santos, Dyego Leando Bezerra de Souza, Taynãna César Simões

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: uterine cervical neoplasms; mortality; age-period-cohort analysis; forecasting; Brazil

Online: 16 February 2022 (05:03:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0506.v1

A Retrospective Cohort Study of the Clinical Features, Pathological Characteristics, and Molecular Classification in Reproductive Age Patients with Endometrial Cancer who Experienced Unsuccessful Fertility-sparing Treatment

Tong Yu, Xi-Wen Zhang, Ping-Li Sun, Abdulkarim Mohamed Farah, Yan Jia

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometrial cancer; fertility-sparing management; molecular classification; reproductive age; pregnancy

Online: 26 November 2021 (12:42:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0446.v1

Non-Modifiable Risk Factors (Age and Sex), Stroke Types, and Outcomes in Rivers State, Nigeria: A Retrospective Hospital-Based Study

Osborne Ikechuckwu Osuegbu, Foluke Olukemi Adeniji, Golden Chukwuemaka Owhonda, Rogers Bariture Kanee, M Alblihed, Gaber El-Saber Batiha, Eric Osamudiamwen Aigbogun

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Age; Sex; Stroke Types; Outcomes; SEM; Tertiary Hospitals; Rivers State

Online: 20 July 2021 (11:45:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0696.v1

Revealed Preferences of Fourth Graders When Requesting Face-to-Face Help While Doing Math Exercises Online

Roberto Araya, Raúl Gormaz

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Help Seeking; Same-age Peer Tutoring; Revealed Preferences; Data analytics

Online: 29 June 2021 (11:36:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0392.v1

Prevalence of Controlled Systemic Hypertension and Its Associated Risk Factors among Hypertensive Patients at Mbeya Zonal Referral Hospital, Tanzania.

Samson Peter Mvandal, Victor Jastin Mwinuka

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Age; adherence; anti-hypertensive; Controlled hypertension; clinic; hypertension; Prevalence; Systemic

Online: 17 May 2021 (15:57:01 CEST)

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Working Paper REVIEW

A Systematic Review of Neuroimaging and Acute Cannabis Exposure in Age-of-Risk for Psychosis

Lani Cupo, Eric Plitman, Elisa Guma, M Mallar Chakravarty

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: systematic review; cannabis; neuroimaging; age-of-onset psychosis; psychosis; schizophrenia

Online: 14 May 2021 (09:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0589.v1

Compaction Model for Shale in Differences of Geological Ages Using A 3D Empirical Relationship in Northeastern Thailand

Avirut Puttiwongrak, Syukratun Nufus, Chaiyaphruk Bunprasert, Pham Huy Giao, Sakanann Vann, Thongchai Suteerasak, Nophea Sasaki

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Shale compaction; Geological age; Thailand shale; Compaction model; Standard curve

Online: 21 April 2021 (16:50:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0478.v1

Quality of Life: Changes in Self Perception in People with DS who Participate in Laliga Genuine Santander. Self Reports and External Reports

Rocío Camacho, Cristina Castejón-Riber, Francisco Requena, Julio Camacho, Arturo Gallego, Roberto Espejo, Amaranta De Miguel-Rubio, Begoña M. Escribano, Estrella I. Agüera

Subject: Social Sciences, Psychology Keywords: Down's Syndrome; perception; quality of life; sport; age; gender; scale

Online: 18 December 2020 (16:17:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0090.v1

Tapering, Tree Rings and Biomass Production of Pinus roxburghii (Sarg.): A Dendrochronological Study

Hari Prasad Pandey, Narayan Prasad Pokhrel

Subject: Biology And Life Sciences, Forestry Keywords: age; coring sample; forest productivity; Nepal; P. roxburghii; stand structure

Online: 4 September 2020 (08:08:30 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0005.v1

Age-Adaptive and Gender-Balanced Social Interventions Might Be Stepping Stones to the Next ‘New Normal’ in COVID-19 Outbreak

Carlo Vittorio Cannistraci, Ilaria Capua

Subject: Biology And Life Sciences, Virology Keywords: social intervention; COVID-19; health policy; public health; age; gender

Online: 2 May 2020 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0051.v3

Bulk and Single-Cell Transcriptomics Identify Tobacco-Use Disparity in Lung Gene Expression of ACE2, the Receptor of 2019-nCov

Guoshuai Cai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Wuhan 2019-nCov; ACE2; expression; susceptibility; race; age; gender; smoking; single cell

Online: 2 March 2020 (01:38:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0380.v1

Physical Activity in Elderly Kidney Transplant Patients with Multiple Renal Arteries

Armando Calogero, Caterina Sagnelli, Gaia Peluso, Antonello Sica, Maria Candida, Silvia Campanile, Gianluca Minieri, Paola Incollingo, Massimiliano Creta, Luigi Pelosio, Vincenzo Tammaro, Alessandro Scotti, Akbar Jamshidi, Marcello Caggiano, Evangelista Sagnelli, Concetta Anna Dodaro, Nicola Carlomagno, Michele Santangelo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: physical activity; kidney transplantation; elder age; vascular anomalies; marginal kidneys

Online: 29 December 2019 (11:06:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0236.v1

Growth Opportunities and Earnings Quality from Emerging Economies

Jerry Danjuma kwarbai, Rufus Ishola Akintoye, Festus Fola Adegbie, Apollos Nwabuisi Nwaobia

Subject: Business, Economics And Management, Accounting And Taxation Keywords: earnings quality; growth opportunities; discretionary accruals; corporate age; corporate size

Online: 23 August 2019 (04:40:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0260.v1

Evaluation of Questionnaire Data Views on the Design of Living Space for Different Situations in Life

Carsten Brausch, Dušan Katunský, Jana Katunská

Subject: Engineering, Civil Engineering Keywords: interior design; questionare; life situation; data evaluation; different age groups

Online: 23 April 2019 (13:12:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1690.v1

Isolation and Characterization of Cell-Free DNA from Cerebral Organoids

Brian B. Silver, Ashley Brooks, Kevin Gerrish, Erik J Tokar

Subject: Cell And Developmental Biology, Biology And Life Sciences Keywords: biomarkers; cell-free DNA; cerebral organoid; new approach methodologies; liquid biopsy

Online: 25 April 2024 (16:10:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1786.v1

Isolation and Identification of New Pathogen Causing Sunflower Disk Rot in China

Jianfeng Yang, Jian Zhang, Wenbing Zhang, Mandela E Addrah, Baoyu Liu, Jun Zhao

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: sunflower disk rot; Fusarium verticillioides; new pathogen; fungicide screenings

Online: 29 March 2024 (03:58:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1041.v1

REFS - A Risk Evaluation Framework on Supply Chain

Istvan Mihalcz

Subject: Business, Economics And Management, Business And Management Keywords: Supply chain; FMEA; new FMEA; Risk Evaluation Framework; TREF; Fuzzy FMEA

Online: 14 December 2023 (10:05:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0535.v1

Detection Ground Deformation characteristics of Reclamation Land with Time-Series InSAR in Tianjin Binhai New Area,china

Yanan Chen, Fu li Yan, Jian Chen, Tao Xiang Fan

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Ground Settlement; Marine Reclamation Land; SBAS-InSAR; Tianjin Binhai New Area

Online: 7 September 2023 (12:12:14 CEST)

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In order to alleviate the conflict between populations and land-resource, Tianjin has adopted multi-phase reclamation projects to formed large-scale artificial reclamation land. However, the reclamation areas are susceptible to subsidence, which demonstrate a serious threat to infrastructure and people’s lives and property. The SBAS-InSAR was used to acquired surface deformation of Tianjin Binhai New Area from January 2017 year to December 2022 year, analyzed in depth the response relationship between land subsidence and reclamation projects time as well as the land use type. The results show that the Lingang Industrial Zone was the earliest to be reclaimed, with extensive reclamation completed by 2016 year, while Nangang Industrial Zone and Hangu Port started reclamation projects in 2009 year, some areas are still currently under construction. There is a strong correlation between surface deformation and reclamation time, the severe land subsidence occurred over newly reclaimed areas. Surface deformation gradually intensifies from west to east, the maximum surface settlement in Nangang Industrial Zone, Lingang Industrial Zone from the west to the east has changed from -50 mm to -890 mm,45 mm to -580 mm, respectively, reclamation area of Hangu Port with maximum surface deformation is -250 mm. Significant differences deformation among different land use types, which reclamation projects completed in the same time. Subsidence is positively correlated with surface load, in areas with higher surface loads, the surface settlement is also severer,the average surface settlement for the heavy shipyard, 67 grain storage tanks, 27 grain storage tanks, road, and bare land are -201 mm, -166 mm, -107 mm, -64 mm, and -43 mm, respectively. This study reveals significant differences of surface deformation in the reclamation completed at different times and the load is the main driving factor of settlement difference in the reclamation land completed at the same time. Which has important guiding significance for preventing and controlling geological disasters in the reclamation area and later development planning.

Preprint ARTICLE | doi:10.20944/preprints202308.1674.v3

Revision of the Genus Sycanus Amyot & Serville, 1843 (Heteroptera: Reduviidae: Harpactorinae) from China Based on DNA Barcoding and Morphological Evidence

Ping Zhao, Suyi Chen, Jianyun Wang, Zhuo Chen, Hu Li, Wanzhi Cai

Subject: Biology And Life Sciences, Insect Science Keywords: China; Sycanus; taxonomy; DNA barcoding; species delimitation; phylogeny; new species; biology

Online: 5 September 2023 (02:40:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1977.v1

Unveiling the Enigma of Quality Assurance in Private School Institutions: Unraveling Challenges, Bridging Gaps, and Pioneering New Perspectives

Edgar Eslit

Subject: Social Sciences, Education Keywords: bridging gaps; challenges; pioneering new perspectives; private school institutions; quality assurance

Online: 28 June 2023 (10:10:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1322.v1

Intra-Active Inference I: Fundamentals

Ali Rahmjoo, Mahault Albarracin

Subject: Arts And Humanities, Philosophy Keywords: free energy principle; active inference; new materialism; intra-action; agential realism

Online: 19 June 2023 (08:35:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0762.v1

Operational Matrix of New Shifted Wavelet Functions for Solving Optimal Control Problem

Gufran Abass, Suha Shihab

Subject: Computer Science And Mathematics, Mathematics Keywords: New shifted wavelet functions; optimal control problem; Convergence criteria; Error analysis

Online: 12 June 2023 (05:05:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0627.v1

An Evolutionary Analysis of Higher-Order Interaction Collaborative Innovation Networks in China's New Energy Vehicle Industry

Yuan Yuan, Jinli Guo, Zhaohua Guo

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: New energy vehicle; Higher-order interaction network; Generalized degree; Simplicial complex

Online: 8 June 2023 (10:35:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0157.v1

Effect of Environmental Turbulence on New Product Development: A Case of Serial Mediation of Strategic Flexibility and Bricolage in High-Tech Industries of Chengdu, China

Luo Kuankuan, Liming Zhang

Subject: Business, Economics And Management, Business And Management Keywords: Bricolage; Environmental Turbulence; High-Tech Industries; New Product Development; Strategic Flexibility

Online: 10 June 2022 (08:39:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0094.v1

A Randomized, Placebo Controlled, Double Blinded, Parallel Group Clinical Study to Evaluate the Efficacy and Safety of AEV01 for Mild COVID19 in Elderly Patients at Risk of Complications

RAMESH KANNAN, VANITHA MURALIKUMAR, VAMSEEDHAR ANNAM, SAKTHI BALAN, ARAVINDA KUMAR, SEKHAR MM, RENU MEDASANI

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; Picrorhiza kurroa; AEV01; NEW Score; Immunomodulatory; unvaccinated elderly population

Online: 7 May 2022 (05:47:32 CEST)

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Background: While several drugs are in the pipeline for treatment of various grades of COVID-19 disease, none of them have shown promise until now. Medicinal plants are crucial in developing and developed countries for their primary and basic health needs owing to better tolerability, superior compatibility with human body and having lesser side effects. AEV01 , a speciality extract of kutki (Picrorhiza kurroa), is one potential medicinal herb which can be effective for mild COVID19 in elderly patients at risk of complications and aging immunity. Purpose: The efficacy and safety of AEV01 for mild COVID-19 in elderly patients at risk of complications was investigated in this study. Study design: A prospective, phase 3, randomized, multicentric, placebo controlled double blinded parallel group interventional trial. Methods: This study was conducted in elderly patients diagnosed as COVID-19 with mild symptoms. 70 patients were randomized into two groups to receive AEV01 capsule (100mg) and placebo respectively thrice daily for 30 days along with standard care of treatment as per national WHO/ICMR guidelines. Clinical improvement timelines and corresponding scores using 8-point ordinal scale and NEWS were assessed for efficacy and safety of AEV01 in COVID-19 patients. Results: AEV01 group showed a significant improvement (P=0.0001) in the normalization of the SpO₂ rate and relief from cough. There was also significant difference in time to recovery, with patients in the AEV01 drugtreated group recovering in 4.5 days as compared to Placebo in 9.1 days. ESR, LDH, serum ferritin, Neutrophil-Lymphocyte ratio (NLR), TNF- alpha, IL-6 and CD4 cell counts, which are considered as prognostic markers in COVID19 infected patients, showed a significant improvement in patients treated with AEV01. The AEV01 drug treated group showed significant clinical improvement in the 8-point ordinal scale severity rating and NEW Score from day 3 onwards which continued up to end of study. Conclusion: AEV01 has shown a significant improvement in clinical and laboratory parameters. There was also reduction in the progression of the COVID-19 disease in unvaccinated elderly patients from mild to moderate when treated at an earlier stage.

Preprint ARTICLE | doi:10.20944/preprints202201.0369.v1

Anomalous Geomagnetic Signal Emphasized Before the Mw8.2 Coastal Alaska Earthquake, Occurred on 29 July 2021

Dragoș Armand Stănică

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: geomagnetic polarization parameters; precursory geomagnetic; Mw8.2earthquake; CMO and NEW observatories -Alaska

Online: 25 January 2022 (08:30:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0287.v1

The influence of institutional support on innovation performance of new ventures: the mediating mechanism of entrepreneurial orientation

Yang Jie, Mingxing Yu

Subject: Business, Economics And Management, Business And Management Keywords: Institutional support; new ventures; entrepreneurial orientation; innovation resource acquisition; innovation performance.

Online: 20 January 2022 (08:12:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0399.v1

Fine-Scale Urban Heat Patterns in New York City Measured by ASTER Satellite – The Role of Complex Spatial Structures

Bibhash Nath, Mutlu Ozdogan, Wenge Ni-Meister

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Urban Heat Island; Building Footprint; Remote Sensing; ASTER; New York City

Online: 19 August 2021 (10:35:33 CEST)

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Urban areas have very complex spatial structures. These spatial structures are primarily composed of a complex network of built environments, which evolve rapidly as the cities expand to meet the growing population’s demand and economic development. Therefore, studying the impact of spatial structures on urban heat patterns is extremely important for sustainable urban planning and growth. We investigated the relationship between surface temperature obtained by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER, at 90 m spatial resolution) on the current EOS-Terra platform and different urban components based on the classification of high-resolution QuickBird imagery. We further investigated the relationships between surface temperature and building footprint and land use information acquired from the New York City (NYC) Department of City Planning. The ASTER image reveals fine-scale urban heat patterns in the NYC metropolitan region. The dark and medium-dark impervious surfaces, along with bright surfaces, generate higher surface temperatures. Even with highly reflective urban materials, the presence of impervious materials leads to an increased surface temperature. At the same time, trees and shadows are effective in reducing urban heat. The data aggregated to the census tract reveals high-temperature clusters in Queens, Brooklyn, and the Bronx region of NYC. These clusters are associated with industrial and manufacturing areas and multi-family walk-up buildings as dominant land use. The census tracts with more trees and higher building height variability generate lower surface temperatures, consistent with shadow cast by high-rise buildings and trees. The results of this study can be valuable for urban heat island modeling on the effects of building heights variability and tree shadows on small-scale surface temperature patterns. It can also help identify the risk areas during extreme heat events to protect public health.

Preprint ARTICLE | doi:10.20944/preprints202102.0080.v1

Metabolite Structure Assignment of Seized Products Containing Cathinone Derivatives through High Resolution Analytical Techniques

João Gonçalves, Vera L. Alves, Joselin Aguiar, Maria Caldeira, Helena Teixeira, José S. Câmara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Chemical characterization; New psychoactive substances; Synthetic cathinones; FTIR; GC-MS; NMR

Online: 2 February 2021 (09:44:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0220.v1

Medical Education Adaptations Post COVID-19 - An Egyptian Reflection

Mohamed Hany Shehata, Enjy Abouzeid, Nourhan Wasfy, Adel Abdelaziz, Ray L. Wells, Samar A. Ahmed

Subject: Social Sciences, Education Keywords: COVID-19; online learning; new teaching and assessment methods; medical education

Online: 17 June 2020 (13:23:11 CEST)

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Coronavirus (COVID19) appears to be an inflection point that is forcing a disruption in medical education. However, it is not clear what the responses of the institutions are to this pandemic and how the adaptation of new methods may impact medical education in the post COVID-19 era. Objective: The study aims to explore how medical schools in Egypt responded to COVID-19 pandemic regarding the teaching and learning/assessment for undergraduate students. Design: A mixed method exploratory two-phase study was conducted. A survey was prepared and disseminated to a convenient non-probability sample of the medical school faculty through various social platforms. Then, a focus group guide was conducted to explore in more depth the findings. Results: The staff level of preparedness for that unexpected shift was evaluated by 55.1% of the survey participants as optimum to high and a good leadership support was reported by 70 % of them. They reported conflicting views about the proper role of medical education units but reinforced the idea of Egyptian Knowledge Bank’s crucial role in this transition. Additionally, there is a communication problem with the students that leads to their detachment. Subsequently, 84.6 % of the participants reported that their schools used alternative teaching methods for small groups, large groups, pre-clinical and clinical clerkships. However, 64.1 % of the participants identified a clinical skills teaching challenge. Although, 68.4% reported that alternative methods were used for formative assessment but absence of alternative methods for summative assessment was declared by 76.3%. Conclusions: Individuals moved faster than bodies and relied on support existing outside the universities when catastrophe happened. However, institutes which have experience in adapting modern engaging learning methods should organize a better response for crisis. Online learning should be integrated in the curriculum with a fair percentage especially in the early years of medical study.

Preprint ARTICLE | doi:10.20944/preprints202005.0134.v1

A Crispr-Cas9 System Designed to Introduce Point Mutations into the Human ACE2 Gene to Weaken the Interaction of the ACE2 Receptor with the SARS-CoV-2 S Protein

Pedro Tanaka, Jadson Santos, Ernna Oliveira, Natane Miglioli, Amanda Assis, Ana Monteleone-Cassiano, Vitor Ribeiro, Max Duarte, Mayara Machado, Romario Mascarenhas, Alex Souza, Leticia Brito, Leticia Oliveira, Eduardo Donadi, Geraldo Passos

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Crispr-Cas9; ACE2 gene; SARS-CoV-2; new coronavirus; COVID-19

Online: 7 May 2020 (15:26:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0245.v1

120 Years of Untangling the Divaricate Habit: A Review

Kévin J. L. Maurin, Christopher H. Lusk

Subject: Biology And Life Sciences, Plant Sciences Keywords: convergent evolution; divaricating shrubs; heteroblasty; moa; New Zealand; structural plant defences

Online: 15 April 2020 (10:31:08 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0213.v1

Coronavirus ORF1ab Polyprotein Associated Nsp16 Protein is a RlmE Methyltransferase and May Methylate 21S Mitochondrial rRNA of Host Cells Inhibiting Protein Synthesis

Asit Kumar Chakraborty

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: covid-19; rlmE MTase; new drug target; corona diagnosis; corona pandemic

Online: 13 April 2020 (12:33:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0026.v2

Expanding the Diversity of Myoviridae Phages Infecting Lactobacillus Plantarum - A Novel Lineage of Lactobacillus Phages Comprising Five New Members

Ifigeneia Kyrkou, Alexander Byth Carstens, Lea Ellegaard-Jensen, Witold Kot, Athanasios Zervas

Subject: Biology And Life Sciences, Virology Keywords: Lactobacillus plantarum; phage; new genus; annotation; comparative genomics; phylogenetics; isolation; diversity

Online: 11 June 2019 (09:54:23 CEST)

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