Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1)

Zsolt Abonyi-Tóth
ORCID logo ,
György Rokszin
,
Ibolya Fábián
,
Zoltán Kiss
,
György Jermendy
ORCID logo ,
Péter Kempler
,
Csaba Lengyel
,
István Wittmann
* ORCID logo ,
Gergő A. Molnár
ORCID logo ,
Gábor Sütő
Version 1 : Received: 16 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (10:20:11 CET)

How to cite: Abonyi-Tóth, Z.; Rokszin, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A.; Sütő, G. Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1). Preprints 2024, 2024021034. https://doi.org/10.20944/preprints202402.1034.v1 Abonyi-Tóth, Z.; Rokszin, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A.; Sütő, G. Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1). Preprints 2024, 2024021034. https://doi.org/10.20944/preprints202402.1034.v1

Abstract

(1) Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cancer but how these two diseases associate is still debated. The goal was the assessment of the overall incidence of cancer among patients with newly diagnosed T2DM in Hungary. Summarizing, incident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months. (2) Methods: A nationwide, retrospective, longitudinal study was performed using a Hungarian database. The incident T2DM and diabetes free Hungarian population were included in the study. The primary endpoints were the overall and site-specific incidence and annual percentage change of the incidence of cancer in both populations. (3) Results: The overall incidence of cancer in patients amounted to 29.4/1000 and 6.6/1000 with or without T2DM, respectively, and the OR (95%CI) of cancer of the T2DM group was 4.32 (4.14-4.53), p<0.0001. The risk of having cancer was age-dependent, having the highest odd in the age group 18-39. The incidence of cancer was declining in the non-diabetic but was unchanged in T2DM population. The average lag time of diagnosing a cancer after the detection of T2DM was 3.86 months.; (4) Conclusions: Iincident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months.

Keywords

Type 2 diabetes mellitus; epidemiology; cancer; incidence; new-onset diabetes

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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