Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Retrospective Cohort Study of the Clinical Features, Pathological Characteristics, and Molecular Classification in Reproductive Age Patients with Endometrial Cancer who Experienced Unsuccessful Fertility-sparing Treatment

Version 1 : Received: 24 November 2021 / Approved: 26 November 2021 / Online: 26 November 2021 (12:42:15 CET)

How to cite: Yu, T.; Zhang, X.; Sun, P.; Farah, A.M.; Jia, Y. A Retrospective Cohort Study of the Clinical Features, Pathological Characteristics, and Molecular Classification in Reproductive Age Patients with Endometrial Cancer who Experienced Unsuccessful Fertility-sparing Treatment. Preprints 2021, 2021110506 (doi: 10.20944/preprints202111.0506.v1). Yu, T.; Zhang, X.; Sun, P.; Farah, A.M.; Jia, Y. A Retrospective Cohort Study of the Clinical Features, Pathological Characteristics, and Molecular Classification in Reproductive Age Patients with Endometrial Cancer who Experienced Unsuccessful Fertility-sparing Treatment. Preprints 2021, 2021110506 (doi: 10.20944/preprints202111.0506.v1).

Abstract

Conclusions: Molecular classification could provide reliable supplementary information for evaluating prognostic and contribute to treatment option decision-making in EEC patients. Fertility-sparing treatment is not recommended for EEC patients with CNH and MSI-H. Furthermore, fertility-sparing treatment can be attempted in EEC patients with CHL, but regular follow-up should be carried out to early detection of EC relapse and prevention of disease progression.

Keywords

endometrial cancer; fertility-sparing management; molecular classification; reproductive age; pregnancy

Subject

MEDICINE & PHARMACOLOGY, Obstetrics & Gynaecology

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