The origins of the stellar mass neutron black holes and supermassive dark matter black holes without the singularities are reported based on the 4-D Euclidean space. The neutron black holes with the mass of m_BH = 5 – 15 m_sun are made by the 6-quark merged states (N_6q) of two neutrons with the mass (m(N_6q) = 10 m(n)) of 9.4 GeV/c² that gives the black hole mass gap of m_BH = 3 – 5 m_sun. Also, the supermassive black holes with the mass of m_SMBH = 10⁶ – 10¹¹ msun are made by the merged 3-D states (J(B1B2B3)₃ particles) of the dark matters. The supermassive black hole at the center of the Milky way galaxy has the mass of mSMBH = 4.1 10⁶ m_sun that is consistent with m_SMBH = 2.08 - 6.23 10⁶ m_sun calculated from the 3-D states (J(B1B2B3)₃ particles) of the dark matters with the mass of m(J) = 1.95 10¹⁵ eV/c². In other words, this supports the existence of the B1, B2 and B3 dark matters with the proposed masses. The first dark matter black hole (primary black hole) was created at the big bang. This first dark matter black hole decayed to the supermassive dark matter black holes through the secondary dark matter black holes that are explained by the merged states of the J(B1B2B3)₃ particles. The universe evolution is closely connected to the decaying process of the dark matter black holes since the big bang. The dark matter cloud states are proposed at the intermediate mass black hole range of m_IMBH = 10² – 10⁵ msun. This can explain why the dark matter black holes are not observed at the intermediate mass black hole range of m_IMBH = 10² – 10⁵ m_sun.

We show the tensor properties of joint probabilities on a Riemannian parametric manifold. Initially we develop a binary data matrix for parameter measurements of a large number of particles confining in a closed system in order to retrieve the joint probability densities of related parameters. By introducing a new generalized inner product as a multilinear operation on dual basis of parametric space, we extract the set of joint probabilities and prove them to meet contravariant tensor properties in a general Riemannian parametric space. We show these contravariant tensors reduce to classical ordinary partial derivatives definition in ordinary Euclidean parametric space. Finally we prove by a theorem that symmetrized iterative contravariant derivative of cumulative probability function on Riemannian manifold gives the set of joint probabilities in those manifold. We bring some examples for compatibility with physical tensors.

In this paper, a method is developed for presenting a novel virtual torque sensor based on precise model and position measurements avoids the need of traditional strain gauges and amplifiers. More specifically, the harmonic drive compliance model and the Gaussian process regression (GPR) technique are used together to achieve virtual torque sensor measurement. While the harmonic drive compliance model provides the analytic part, the Gaussian process regression method is used to reconstruct the unmolded part based on motor-side and link-side joint angles as well as motor current. After an automatic offline calibration, the method allows for a lean online implementation. The virtual torque sensor measurement is compared with measurements of a commercial torque sensor, and the results have attested the effectiveness of the proposed method.

In this paper after introducing a model of binary data matrix (BDM) for physical parameters of an evolving system (of particles), we develop a Hilbert space as an ambient space to derive induced metric tensor on embedded parametric manifold identified by associated joint probabilities of particles observables (parameters). Parameter manifold assumed as space-like hypersurface evolving along time axis, an approach that resembles 3+1 formalism of ADM and numerical relativity. We show the relation of endowed metric with related density matrix. Identification of system density matrix by this metric tensor, leads to the equivalence of quantum Liouville equation and metric compatibility condition while covariant derivative of metric tensor has been calculated respect to Wick rotated time or spatial coordinates. After deriving a formula for expected energy per particles, we prove the equality of this expected energy with local scalar curvature of related manifold. We show the compatibility of BDM model with Hamilton-Jacobi formalism and canonical forms. On the basis of the model, I derive the Ricci flow like dynamics as the governing dynamics and subsequently derive the action of BDM model and Einstein field equations. Given examples clarify the compatibility of the results with well-known principles such as equipartition energy principle and Landauer’s principle. This model provides a background for geometrization of quantum mechanics compatible with curved manifolds and information geometry. Finally, we conclude a “bit density principle” which predicts the Planck equation, De Broglie wave particle relation, , Beckenstein bound and Bremermann limit.

The way people innovate and create new ideas and bring them to the market is undergoing a fundamental change from closed innovation to open innovation. Why and how do firms perform open innovation? Firms’ open innovation is measured through the levels of firms’ joint patent applications. Next, we analyze network structures and characters of firms’ joint patent applications such as betweenness and degree centrality, structure hole, and closure. From this research, we drew conclusions as follows. First, the structure of collaboration networks has both direct and indirect effects on firms’ innovative performance. Second, in the process of joint patent applications, there is a long tail phenomenon in networks of joint patent applications. Third, the number of patents and International Patent Classification (IPC) subclasses together constitute a meaningful measure of the innovation performance of firms.

Plant leaf area index (LAI) is a key characteristic affecting field canopy microclimate. In addition to traditional professional measuring instruments, smartphone camera sensors have been used to measure plant LAI. However, when smartphone methods were used to measure conifer forest LAI, very different performances were obtained depending on whether the smartphone was held at the zenith angle or at a 57.5° angle. To validate further the potential of smartphone sensors for measuring conifer LAI and to find the limits of this method, this paper reports the results of a comparison of two smartphone methods with an LAI-2000 instrument. It is shown that both methods can be used to reveal the conifer leaf-growing trajectory. However, the method with the phone oriented vertically upwards always produced better consistency in magnitude with LAI-2000. The bias of the LAI between the smartphone method and the LAI-2000 instrument was explained with regard to four aspects that can affect LAI: gap fraction, leaf projection ratio, sensor field of view (FOV), and viewing zenith angle (VZA). It was concluded that large FOV and large VZA cause the 57.5° method to overestimate the gap fraction and hence underestimate conifer LAI, especially when tree height is greater than 2.0 m. For the vertically upward method, the bias caused by the overestimated gap fraction is compensated for by an underestimated leaf projection ratio.

By using 0.35-um CMOS process, this work achieves a design of analogous band-gap reference voltage circuit with low temperature coefficient. The proposed circuit operates at 3V and generates a reference current of 44 uA. The HSPICE simulation results show the temperature coefficient of this circuit is 23 ppm/℃ at range of -10 ℃ to 100 ℃, and the line regulation (the ratio of output current variation to supply voltage variation) is estimated as 1.95 uA/V from supply voltage variation of 3 V to 5 V. The experimental chip is fabricated and measured. The circuit provides adjustable capability for output voltage among temperature variation of -10 - 100 ℃. The chip area is 534 × 695 um^2. In this new design, the operational amplifier is not necessary. The chip design effort can be great reduced.

This study describes all the properties of high T_c cuprates by introducing rotating holes that are created by angular momentum conservations on a 2D CuO₂ surface, and which have a different mass from that of a normal hole because of the magnetic field energy induced by the rotation. This new particle called a macroscopic Boson describes the doping dependences of pseudo-gap temperature and the transition temperature at which an anomaly metal phase appears and describes the origin of the pseudo-gap. Furthermore, this study introduces a new model to handle many-body interactions, which results in a new statistic equation. This statistic equation describing many-body interactions accurately explains why high T_c cuprates have significantly high critical temperatures. Moreover a partition function of macroscopic Bosons describes all the properties of anomaly metal phase, which sufficiently agree with experiments, using the result from our previous study [1] that analytically describes the doping dependence of T_c. By introducing a macroscopic Boson and the new statistical model for many-body interactions, this study uncovered the mystery of high T_c cuprates, which have been a challenge for many researchers. An important point is that, in this study, pure analytical calculations are consistently conducted, which agree with experimental data well (i.e., they do not use numerical calculations or fitting methods but use many actual physical constants).

The nationwide lockdown imposed to control the spread of novel coronavirus induced dramatic alterations in different sectors of the Nepalese governance, including Solid Waste Management (SWM) practices. The study identifies SW collection gaps in seven major cities of Nepal and highlights the municipal and public households on SW management practices before and during the lockdown to emphasize the linkage between COVID-19 and SWM. It includes information on solid waste status, collection frequency and coverage, workers safety practices, types of vehicles operated for collection and alternative methods adopted by households to manage SW during the lockdown. For this, 1329 households survey and key informant interviews were conducted in seven cities of Nepal during the lockdown. It was found that although the coverage of the collection service was similar during the pandemic, there was a drastic decrease in the collection frequency leading to a collection gap of around 570 tons/day. More than 50% of the surveyed households adopted no proper alternative measures as they claimed that they stored solid waste with proper management so that municipal authorities can take it. The study reveals poor occupational health and safety practices among the solid waste workers due to the unavailability of safety gears and equipment despite being aware of the modes of transmission of the virus. The pandemic exacerbated the challenges of smooth SWM as it is an essential and needy service. This study highlights the need for a timely strategic management framework to be developed by the government to continue the smooth SWM practices during the lockdown.

The Estimation of systemic risk in India is still in its infancy stage. There are several methods which are available but none of the methods are fully compatible to forecast the systemic risk since under different circumstances the factors responsible for the risk differs. In this paper the systemic risk estimation in India being carried out based on spread in daily stock market price(Difference between the bid and ask price of a share) of the top 100 firms in India according to market capitalization for the period of July2007 to March 2016. The results were compared with the Financial Stability Report published by Reserve Bank Of India for the period of March 2010 to June 2016.The results clearly indicates that there exits relationship between market illiquidity represented by spread and risks associated with the Financial System. In most of the cases the Z score (deviation from the mean/Standard Deviation) of the spread has become negative which provides the spread which is farther from the mean, also a good indicator of volatility in market and risk to financial system. It is also seen that the Systemic Risk Survey conducted by Reserve Bank of India which started during October 2011 has supported the results.

Stabilized un-doped Zinc Telluride (ZnTe) thin films were grown on glass substrates under vacuum using closed space sublimation (CSS) technique. A dilute copper nitrate solution (0.1/100 ml) was prepared for copper doping known as ion exchange process in the matrix of ZnTe thin film. The reproducible polycrystalline cubic structure of undoped and Cu doped ZnTe thin films with preferred orientation (111) was confirmed by X-rays diffraction (XRD) technique. Lattice parameter analyses verified the expansion of unit cell volume after incorporation of Cu species into ZnTe thin films samples. The micrographs of scanning electron microscopy (SEM) were used to measure the variation in crystal sizes of samples. The energy dispersive X-rays was used to validate the elemental composition of undoped and Cu-doped ZnTe thin films. The bandgap energy 2.24 eV of ZnTe thin film decreased after doping Cu to 2.20 eV may be due to the introduction of acceptors states near to valance band. Optical studies showed that refractive index was measured from 2.18 to 3.24 whereas thicknesses varied between 220 nm to 320 nm for un-doped and Cu doped ZnTe thin film respectively using Swanepoel model. The oxidation states of Zn⁺², Te⁺² and Cu⁺¹ through high resolution X-ray photoelectron spectroscopy (XPS) analyses was observed. The resistivity of thin films changed from ~10⁷ Ω-cm for undoped ZnTe to ~1 Ω-cm for Cu-doped ZnTe thin film, whereas p-type carrier concentration increased from to respectively. These results predicted that Cu-doped ZnTe thin film can be used as an ideal, efficient and stable intermediate layer between metallic and absorber back contact for the heterojunction thin film solar cell technology.

Load transfer through orthopaedic joint implants is poorly understood. The longer-term outcomes of these implants are just starting to be studied, making it imperative to monitor contact loads across the entire joint implant interface to elucidate the force transmission and distribution mechanisms exhibited by these implants in service. This study proposes and demonstrates the design, implementation, and characterization of a 3D-printed smart polymer sensor array using conductive polyaniline (PANI) structures embedded within a polymeric parent phase. The piezoresistive characteristics of PANI were studied to characterize the sensing behaviours inherent to these embedded pressure sensor arrays. PANI's stable response to a continuous load, its stability throughout loading and unloading cycles, and its repeatable and linear response to incremental loading cycles together with the accuracy of these measurements were investigated. It is demonstrated that this specially developed multi-material additive manufacturing process for polyaniline is an attractive approach for the fabrication of implant components having embedded smart-polymer sensors for the measurement and analysis of joint loads in orthopaedic implants.

Previous study demonstrated the reconstituted type I collagen matrix extracted from rabbit tendons enabled to regenerate the TMJ disc in the rabbit. The aim of this study was to investigate changes in the extracellular matrix (ECM) and mechanisms of regeneration in TMJ disc. In 36 New Zealand rabbits that underwent a partial discectomy, discs were replaced with reconstituted collagen templates for 3 months. A histological analysis showed that moderate to severe degeneration appeared in partially discectomized joints without implantation. In contrast, discs that received the reconstituted collagen template regenerated, and returned to normal to protect the joint. Cells in the regenerative tissue expressed ECM, and fibers became regular and compact due to tissue remodeling over time. Reparative cells differentiated into chondroblasts, and showed highly dense pericellular fibers. The morphology and collagen composition of the disc and condyle in the 3-month experimental group were similar to those of normal tissues. In conclusion, the reconstituted collagen template facilitated the regeneration of surgically discectomized discs. Type I and type II collagens play a crucial role in the regeneration of articular discs.

In general, a superconductor has zero resistance, although it requires significant refrigeration or high pressures with high manufacturing costs, which prevents it into practical applications. In other words, solving these issues implies main superconducting researches. To solve these problems, this paper describes a new type of superconductivity, which is independent for temperatures and which operates without pressures. The principles of the presented system are as follows:First a voltage source, a current source and a load are connected in series. Then, the voltage of the voltage source is adjusted to balance the voltage of the load. Under this condition, the balance of the two voltages provides a zero voltage between the taps of the current source and the generated current from the voltage source becomes zero because of the internal infinite resistance of the current source. As a result, the electric powers generated by the two sources are zero, and therefore, the load cannot generate Joule heating because of energy conservation. However, the current from the current source (not the voltage source) is not zero; therefore, we can predict that the resistance of the load must be zero. As a theory, we derived a new electric field and transient attractive force, which result in a very short coherence of an electron pair because there is not the Coulomb repulsive force due to the existence of the above transient attractive force. Note that both the forces are derived by the Poisson equation, which implies that they cannot be compatible. Therefore, the pair combination energy from spins becomes extremely strong, which is not destroyed by the normal heat energy. Moreover, every center-of-mass motion of electron pair results in the Bose-Einstein condensation and the macroscopic wave function, which produces the London equation (i.e., the Meissner effect). Moreover, by introducing the equivalent circuit, this paper conducted numerical calculations. As a result, we could derive numerically zero resistance and responses for additional static magnetic fields as a discharged current, which implies the Meissner effect. Note that this paper has prepared Appendix section, which provides a guide to reproduce actual experiments and preliminary experimental results. These results in the Appendix indicate the zero resistances and Meissner effects.

In the current study, the failure behavior of retrofitted steel structures was studied experimentally and theoretically with steel/CFRP double strap joints (DSJs) under quasi-static tensile loading. A series of DSJs with different bonding lengths are also considered and examined to experimentally assess the effective bond length. To predict the failure load values of the tested specimens, a new stress-based criterion, namely the point stress (PS) criterion is proposed. Although some theoretical predictive modelling for the strength between steel/CFRP joints under various loading conditions has been presented, in this work by using the new proposed approach, one can calculate rapidly and conveniently the failure loads of the steel/CFRP specimens. Furthermore, to assess the validity of the new proposed criterion, further experimental data on steel/CFRP DSJs available in the open literature are predicted using the PS criterion. Finally, it was found that a good agreement exists between the experimental results and the theoretical predictions based on the PS criterion.

Terrestrial vegetation dynamics are closely influenced by a multitude of factors. This study investigated the relationships between vegetation patterns and their main influencing factors. The joint entropy method was employed to evaluate the dependence between normalized difference vegetation index (NDVI) and coupled variables in the middle reaches of Hei River basin. Based on the spatial distribution of mutual information, the whole study area was divided into five sub-regions. In each sub-region, nested statistical models were applied to model the NDVI on the grid and regional scales, respectively. Results showed that the annual average NDVI increased with a rate of 0.005/a in recent 11 years. In the desert regions, the NDVI increased significantly with an increase in precipitation and temperature, and high accuracy of retrieving NDVI model was obtained by coupling precipitation and temperature, especially in sub-region I. In the oasis regions, groundwater was also an important factor driving vegetation growth, and the rise of groundwater level contributed to the growth of vegetation. However, the relationship was weaker in artificial oasis regions (sub-region III and sub-region V) due to the influence of human activities, such as irrigation. The overall correlation coefficient between the observed NDVI and modeled NDVI was observed to be 0.97. Outcomes of this study are suitable for ecosystem monitoring, especially under the realm of climate change. Further studies are necessary and should consider more factors, such as runoff and irrigation.

Understanding of the decisive role of the interaction mechanism and kinetics in the combustion processes is highly relevant for the elaboration of optimal conditions for obtaining Mo-Cu composite powders. From this perspective, the efficient delivery of the reduction mechanism of copper and molybdenum oxides with combined Mg + C reducing agents at high heating rates is crucial to develop a valuable approach for the combustion synthesis of Mo-Cu composite powders. Herein, we shed light on the mechanism of the reactions in all the studied binary, ternary and quaternary systems contemporaneously demonstrating the effect of the heating rate on the conversion degree. The combination of two highly exothermic and speedy reactions (MoO3+3Mg and CuO+Mg vs MoO3+CuO+4Mg) led to a slow interaction with weak self-heating (dysynergistic effect) due to a change in the reaction mechanism. On the other hand, it has been shown that during the simultaneous utilization of the Mg and C reducing agents, the process begins exclusively with carbothermic reduction, and at relatively high temperatures it continues with magnesiothermic one. The effective activation energy values of the magnesiothermic stages of the studied reactions were determined by Kissinger isoconversional method.

Thin films (100-400 nm) of Ba_xSr_1-xTiO₃ (0≤x≤1) deposited in RF-magnetron co-sputtering equipment are presented in this research work. The change of deposition rate, gap energy, and resistivity as a function of temperature- applied power change in the growth parameters was studied through the ISO colour-code lines constructed with MATLAB: By analysing the trend information and take into account the influence of the calculated "x" parameter with the Boltzmann profile fitting is proposed a method to allow a controlled set up of the RF-magnetron co-sputtering system and predict the E_g and resistivity values in the Ba_xSr_1-xTiO₃ solid solution with 0≤x≤1 for amorphous and crystalline phases. Also, a versatile tool to optimise the deposition process and material properties.

We have studied the relative positions of the frontier levels determine the main electronic properties and reaction ability, there is important necessity to compare the MO of the purine and рyrimidine bases: adenine (A), guanine (G), cytosine (C), thymine (T) and uracil (U). The donor and acceptor properties are the fundamental characteristic of the conjugated molecules and can be quantitatively estimated by relative positions of the frontier molecular orbitals. The MO’s energies can be estimated experimentally or quantum-chemically. Analysis of the relative position of the frontier levels (calibrated by the energy gap) enables the investigation of the donor/acceptor properties of the RNA/DNA bases more detailed. The index φ0 is proposed for the quantitative quantum-chemical estimation of the donor ability of the conjugated molecules: it points on the shifting of the energy gap relative to the reference electron balanced system. The RNA/DNA bases divided strictly by two groups: predominantly donors (φ0 > 0.5) and predominantly acceptors (φ0 > 0.5). Each representative base of the first group forms the stable base pair the representative base of the second group the difference of indices Δφ0 should be optimal to enables the DNA replication.

Soil moisture plays a key role in the Earth’s water and carbon cycles, but acquisition of continuous (i.e., gap-free) soil moisture measurements across large regions is a challenging task due to limitations of currently available point measurements. Satellites offer critical information for soil moisture over large areas on a regular basis (e.g., ESA CCI, NASA SMAP), however, there are regions where satellite-derived soil moisture cannot be estimated because of certain circumstances such as high canopy density, frozen soil, or extreme dry conditions. We compared and tested two approaches--Ordinary Kriging (OK) interpolation and General Linear Models (GLM)--to model soil moisture and fill spatial data gaps from the European Space Agency Climate Change Initiative (ESA CCI) version 3.2 (and compared them with version 4.4) from January 2000 to September 2012, over a region of 465,777 km² across the Midwest of the USA. We tested our proposed methods to fill gaps in the original ESA CCI product, and two data subsets, removing 25% and 50% of the initially available valid pixels. We found a significant correlation coefficient (r = 0.523, RMSE = 0.092 m³m^-3) between the original satellite-derived soil moisture product with ground-truth data from the North American Soil Moisture Database (NASMD). Predicted soil moisture using OK also had significant correlation coefficients with NASMD data, when using 100% (r = 0.522, RMSE = 0.092 m³m^-3), 75% (r = 0.526, RMSE = 0.092 m³m^-3) and 50% (r = 0.53, RMSE = 0.092 m³m^-3) of available valid pixels for each month of the study period. GLM had lower but significant correlation coefficients with NASMD data (average r = 0.478, RMSE = 0.092 m³m^-3) when using the same subsets of available data (i.e., 100%, 75%, 50%). Our results provide support for OK as a technique to gap-fill spatial missing values of satellite-derived soil moisture products across the Midwest of the USA.

Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. This feature is connexin- and tissue-specific and may be mediated by complex signalling pathways through gap junctions or hemichannels or by completely junction-independent events. Lung cancer is the number one cancer in terms of mortality worldwide, and novel biomarkers and therapeutic targets are urgently needed. Our objective was to gain a better understanding of connexins in this setting. We used several in silico tools to analyse TCGA data in order to compare connexin mRNA expression between healthy lung tissue and lung tumours and correlated these results with gene methylation patterns. Using Kaplan-Meier plotter tools, we analysed a microarray dataset and an RNA-seq dataset of non-small cell lung tumours in order to correlate connexin expression with patient prognosis. We found that connexin mRNA expression is frequently either upregulated or downregulated in lung tumours. This correlated with both good and poor prognosis (overall survival) in a clear connexin isoform-dependent manner. These associations were strongly influenced by the histological subtype (adenocarcinoma versus squamous cell carcinoma). We present an overview of all connexins but particularly focus on four isoforms implicated in lung cancer: Cx26, Cx30.3, Cx32 and Cx43. We further analysed the protein expression and localization of Cx43 in a series of 72 human lung tumours. We identified a subset of tumours that exhibited a unique strong nuclear Cx43 expression pattern that predicted worse overall survival (p=0.014). Upon sub-stratification, the prognostic value remained highly significant in the adenocarcinoma subtype (p=0.002) but not in the squamous carcinoma subtype (p=0.578). This finding highlights the importance of analysis of connexin expression at the protein level, particularly the subcellular localization. Elucidation of the underlying pathways regulating Cx43 localization may provide for novel therapeutic opportunities.

Temporomandibular disorders (TMD) is a group of orofacial pain conditions which is the most common non-dental pain complaint in the maxillofacial region. Due to the complexity of the etiology and often cyclical nature of the disease, the diagnosis and management of TMD remain a challenge where consensus is still lacking in many aspects. While clinical examination is considered the most important process in the diagnosis of TMD, imaging may serve as a valuable adjunct in selected cases. Depending on the type of TMD, many treatment modalities have been proposed, ranging from conservative options to open surgical procedures. In this review, the authors discuss the present thinking in the etiology and classification of TMD, followed by the diagnostic approach and the current trend and controversies in management.

At present European buildings typically consume two to five times more energy than predicted at the design stage. An important cause of this performance gap is the discrepancies between the design specification and the As-Built condition. Such discrepancies are mainly due to the gaps in knowhow between design, production and construction professionals. Design is more and more contained into a virtual environment and loses touch with the physical production and construction sites. As the construction sector enters the Industry 4.0 era, Building Information Modelling (BIM) based Mixed Reality can intertwine virtual and real worlds to bridge the knowhow gaps.

Interference fits are a very common shaft-hub connection due to their low manufacturing cost and excellent technical properties. Plastic Conditioning of this machine element is a new and not very well known method. By exploiting residual stresses and the associated increase in the yield point, these components can absorb operating loads such as rotating bending moments, torsion, temperature changes and centrifugal forces purely elastically and avoid plastic deformation during operation. Compared to conventionally joined interference fits, the load bearing capacity in the elastic range can be increased by almost 200% and a specifically defined additional safety against plastic deformation in the elastic-plastic range can be ensured. This paper examines the effects of Reverse Yielding on the technology of Plastic Conditioning of Interference Fits in Power Transmission Engineering. Based on the Shear Stress Hypothesis (SH), the Plane Stress State (PSS) and the ideal plastic behavior of materials, the stress-mechanical relationships are explained, the influencing parameters are examined and conclusions are drawn for the plastic conditioning process. Taking into account the theoretical knowledge according to the state of the art, modified material behavior assumptions (isotropic hardening) and the Von Mises Yield Criterion (VMYC) are also considered. In addition, the method of plastic conditioning of interference fits is introduced and its basic principles are briefly explained. Along with computational suggestions to avoid Reverse Yielding, open issues requiring further research are identified.

The aim of the present study is to investigate both the performance and preferences of males and females Computer Science (CS) graduates. In order to attain the above goal, a quantitative case study was conducted regarding 89 degrees, acquired from 2006 to 2012, from the Department of Computer Science and Technology, University of Peloponnese, Greece. The analysis of the data revealed that in terms of performance, no significant differences between the mean grades of males and females exist, in almost most of the courses included in the curriculum of the aforementioned CS department. Any statistically significant differences in performances were present in almost equal number of courses in favor of males and females. It seems also, that females performed better in the courses they selected more than males. Regarding preferences, in CS courses, it seems that gender differences are existent. Males preferred more than females did core programming courses and advanced topics of Software Systems, computer networks, computer engineering, robotics and mathematics, whereas females preferred more the study of algorithms and security issues, computer fractals, data management, computer architecture, and mobile communication. In addition, females preferred courses in reference with humanities and social sciences, CS terminology, and career opportunities. Yet, females did not select any of programming lab-based courses, computer engineering, computer network issues and robotics.

: The cyber-physical gap (CPG) is the difference between the 'real' state of the world and the way the system perceives it. This discrepancy often stems from the limitations of sensing and data collection technologies and capabilities, and is an inevitable issue in any cyber-physical system (CPS). Ignoring or misrepresenting such limitations during system modeling, specification, design, and analysis can potentially result in systemic misconceptions, disrupted functionality and performance, system failure, severe damage, and potential detrimental impacts on the system and its environment. We propose CPG-Aware Modeling & Engineering (CPGAME), a conceptual model-based approach for capturing, explaining, and mitigating the CPG, on top of and in sync with the conventional system model, and as an inherent systems engineering activity. This approach enhances the systems engineer’s ability to cope with CPGs, mitigate them by design, and prevent erroneous decisions, actions, and hazardous implications. CPGAME is a generic, conceptual approach, specified and demonstrated with Object Process Methodology (OPM). OPM is a holistic conceptual modeling paradigm for multidisciplinary, complex, dynamic systems, which is also ISO-19450. We analyze the 1979 Three Miles Island 2 nuclear accident as a prime example of the disastrous consequences of unmitigated CPGs in complex systems.

In a world where conventional sources of energy are fast depleting, the quest for alternative energy sources may hold the key for the survival of humanity. In the present work, emphasis has been given to the idea of producing energy from perovskite based solar cells. In order to bring this idea into fruition, a unique and novel nano structured perovskite material n-propyl ammonium lead chloride (C₃H₇NH₃⁺PbCl₃⁻) was prepared through a unique co-precipitation route using n-propyl amine (n-C₃H₇NH₂) and hydrochloric acid as the starting precursors with aqueous solution of Pb(CH₃COO)₂3H₂O. Finally acetic acid was added to the solution and this solution was allowed to concentrate and then gradually cooled down to room temperature. After math, the synthesized material was spin-coated on TiO₂ film to fabricate the solar cell. The device was then undergone systematic analysis using XRD, SEM, UV and Photo Conversion to get a transparent idea regarding its structural, electrical and optical properties. When experimentally applied, this perovskite-based solar cell has shown energy conversion efficiency (η) of around 6.01 % which is noticeably good. Thus it can be concluded that this material is promising for fabrication of vastly efficient solar cells. This technology can be tried in large scale as an alternative of conventional energy in the near future.

In this study, two donor-acceptor (D-A) type conjugated polymers namely PQSeCz and PQSeFl were designed and synthesized. Selenophene was incorporated as a π -bridge, quinoxaline as an acceptor unit while carbazole and fluorene were used as the donor units. Polymers were synthesized via palladium catalyzed Suzuki polymerization reaction. All molecules were characterized by 1H and 13C NMR Spectroscopy. The weight and number average molecular weights of the two polymers were determined by gel permeation chromatography (GPC). Electrochemical and spectroelectrochemical characterizations of the polymers were performed to investigate their optoelectronic properties. Oxidation potentials were 1.15 V/ 0.82 V and 1.11 V/ 0.82 V for PQSeCz and PQSeFl respectively, while reduction potentials were -1.26 V /-1.14 V and -1.48 V/ -1.23 V, respectively. In the visible region, maximum absorption wavelengths for the two polymers were 551 nm and 560 nm, respectively. Optical band gaps (Egop) were found from the lowest energy π – π∗ transition onsets as 1.71 eV and 1.58 eV, respectively. Both polymers showed good solubility in common solvents.

Background: India has one-fifth of the world's population and the number of people suffering from mental illness is assumed to be huge considering the contribution of mental disorders to the overall burden of the disease being 13.9 %. Objectives of Study: To estimate prevalence and patterns of mental illnesses to assess the current mental health services and systems in the Madhya Pradesh. Material and Methods: Multi-stage, stratified, random cluster sampling technique, with random selection based on probability proportionate to size at each stage. A total of 3240 individuals aged 18 years and above were interviewed. Both quantitative and qualitative methods were employed. A set of 10 instruments including Mini International Neuro-psychiatric Interview were utilized. Results: The overall weighted prevalence for any mental illness was 16.7% lifetime and 13.9% current. Treatment-gap for all mental health problems is as high as 91% in the state along with huge socioeconomic impact of mental illness. Conclusions: This huge burden of mental, behavioural and substance use disorders, in Madhya Pradesh, calls for immediate attention of political leaders, policy makers, health professionals, opinion-makers and society at large. It is hoped that the data from the study will inform mental health policy and legislation and help shape mental health care delivery systems in the country.

Estimates of extreme water level return periods in river systems are crucial for hydraulic engineering design and planning. Recorded historical water level data of Taiwan’s rivers are not long enough for traditional frequency analyses when predicting extreme water levels for different return periods. In this study, the integration of a one-dimensional flash flood routing hydrodynamic model with the Monte Carlo simulation was developed to predict extreme water levels in the Danshuei River system of northern Taiwan. The numerical model was calibrated and verified with observed water levels using four typhoon events. The results indicated a reasonable agreement between the model simulation and observation data. Seven parameters, including the astronomical tide and surge height at the mouth of the Danshuei River and the river discharge at five gauge stations, were adopted to calculate the joint probability and generate stochastic scenarios via the Monte Carlo simulation. The validated hydrodynamic model driven by the stochastic scenarios was then used to simulate extreme water levels for further frequency analysis. The design water level was estimated using different probability distributions in the frequency analysis at five stations. The design high-water levels for a 200-year return period at Guandu Bridge, Taipei Bridge, Hsin-Hai Bridge, Da-Zhi Bridge, and Chung-Cheng Bridge were 2.90 m, 5.13 m, 6.38 m, 6.05 m, and 9.94 m, respectively. The estimated design water levels plus the freeboard are proposed and recommended for further engineering design and planning.

Strata and surface movement induced by mining under open-pit final slope is a huge threat to mine safety. Physical model test is an important method to study mining-induced strata and surface movement laws. Because of rock joints predominantly control rock mass deformation and failure, thus physical model test leaving out of consideration of rock joints is difficult to reflect the influence of rock joints on rock mass deformation. Therefore, this paper presents a three-dimensional physical model test considering simplified dominant rock joints. This test process includes the design of testing equipment, the construction of physical model with dominant rock joint sets, conduction of mining and deformation monitoring. And mining under eastern final slope of Yanqianshan iron mine was selected as a case to study the behavior of mining-induced strata and surface movement.

Angiogenesis is a complex process that involves interactions between endothelial cells and various other cell types as well as the tissue microenvironment. Several previous studies have demonstrated that mast cells accumulate at angiogenic sites. In spite of the evidence suggesting a relationship between mast cells and angiogenesis, the association of mast cells and endothelial cells remains poorly understood. The present study aims to investigate the relationship between mast cells and endothelial cells during in vitro angiogenesis. When endothelial cells were co-cultured with mast cells, angiogenesis was stimulated. Furthermore, there was direct intercellular communication via gap junctions between the two cell types. In addition, the presence of mast cells stimulated endothelial cells to release angiogenic factors. Moreover, conditioned medium from the co-cultures also stimulated in vitro angiogenesis. The results from this investigation demonstrate that mast cells have both direct and indirect proangiogenic effects and provide new insights into the role of mast cells in angiogenesis.

Background: The Apolipoprotein E4 (ApoE4) genotype is strongly associated with Alzheimer’s disease (AD), although the presence of the ApoE4 allele alone is not sufficient to explain AD. The pathophysiology of amnestic mild cognitive impairment (aMCI) remains unclear. This study aims to examine associations between peripheral blood biomarkers coupled with ApoE4 and episodic and semantic memory. Methods: The CERAD battery was completed and various biomarkers were assayed in 60 subjects with aMCI, 60 with AD and 62 healthy controls. Results: Deficits in semantic and episodic memory were significantly predicted by anion gap and bicarbonate, albumin and glucose coupled with Apo E4. Furthermore, these peripheral biomarkers interacted with ApoE to predict greater memory impairments. Conclusions: Peripheral blood biomarkers may interact with pathways related to ApoE4 to predict greater semantic and episodic memory impairments, thus contributing to the pathophysiology of aMCI and AD. Our data suggest that the transition from aMCI to AD could at least in some cases be associated with significant interactions between ApoE4 and those peripheral blood biomarkers.

This study deals with computational analysis of dominant fatty acid ethyl esters characterized from the biodiesel produced from waste beef tallow by means of KOH catalyzed ethanol based transesterification. Ethyl palmitate, Ethyl Oleate, Ethyl Stearate and Ethyl Myristate were identified as dominant fatty acid esters and were computed for molecular analysis in Gaussian 09 software using Density Functional Theory (B3LYP method) with 6-31G* as basis set. Geometric parameters were in accordance with existing experimental values and population analysis exhibited negative charge for oxygen atoms, both positive & negative charge for carbon atoms in all ester molecules. The molecular dipole moment was higher for unsaturated ester molecule and quadruple moment proposed electronic dislocation in X+Y direction. Also, energy gap decreased slightly with increasing carbon chain but reduced drastically with increase in unsaturation. Electrostatic potential mapping displayed negative electrostatic potential for oxygen atoms in ester linkage of all ester molecules.

Subsurface temperature is the key parameter in geothermal exploration. An accurate estimation of the reservoir temperature is of high importance and usually done either by interpolation of borehole temperature measurement data or numerical modeling. However, temperature measurements at depths which are of interest for deep geothermal applications (usually deeper than 2 km) are generally sparse. A pure interpolation of such sparse data always involves large uncertainties and usually neglects knowledge of the 3D reservoir geometry or the rock and reservoir properties governing the heat transport. Classical numerical modeling approaches at regional scale usually only include conductive heat transport and do not reflect thermal anomalies along faults created by convective transport. These thermal anomalies however are usually the target of geothermal exploitation. Kriging with trend does allow including secondary data to improve the interpolation of the primary one. Using this approach temperature measurements of depths larger than 1,000 m of the federal state of Hessen/Germany have been interpolated in 3D. A 3D numerical conductive temperature model was used as secondary information. This way the interpolation result reflects thermal anomalies detected by direct temperature measurements as well as the geological structure. This results in a considerable quality increase of the subsurface temperature estimation.

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability and function. Here, we summarize these key regulatory events, with emphasis on how these affect their multi-functionality in health and disease.

It appears that up to 80% of females with autistic spectrum disorder (ASD) have not been diagnosed by 18 years of age. This translates to a prevalence of about 5-6%, and if true has serious implications for female mental health. One way of finding the true value is to use Bayes’ Theorem with a comorbid condition as a more easily recognizable flag. An obvious choice is anorexia nervosa (AN), but it transpires that the proportion of women with ASD who develop AN is unknown. This study uses published data in novel ways to provide two methods of estimating a range for this variable, and gives a median value of 8.3% for AN in ASD and with four other methods a median prevalence of 6% for female ASD. The clinical implications for diagnosis and management of ASD and comorbidities are discussed and a solution is provided for the rate of ASD in generalized joint hypermobility.

We are calling for a paradigm shift in engineering education. In times of the Fourth Industrial Revolution (“4IR”), a myriad of potential changes is affecting all industrial sectors leading to increased ambiguity that makes it impossible to predict what lies ahead of us. Thus, incremental culture change in education is not an option any more. The vast majority of engineering education and training systems, having remained mostly static and underinvested in for decades, are largely inadequate for the new 4IR labor markets. Some positive developments in changing the direction of the engineering education sector can be observed. Novel approaches of engineering education already deliver distinctive, student centered curricular experiences within an integrated and unified educational approach. We must educate engineering students for a future whose main characteristics are volatility, uncertainty, complexity and ambiguity. Talent and skills gaps across all industries are poised to grow in the years to come. The authors promote an engineering curriculum that combine timeless didactic tradition, such as Socratic inquiry, project-based learning and first-principles thinking with novel elements (e.g. student centered active and e-learning by focusing on the case study and apprenticeship pedagogical methods) as well as a refocused engineering skillset and knowledge. These capabilities reinforce engineering students’ perceptions of the world and the subsequent decisions they make. This 4IR engineering curriculum will prepare engineering students to become curious engineers and excellent communicators better navigating increasingly complex multistakeholder ecosystems.

Land Surface Temperature (LST) is a basic parameter in energy exchange between the land and atmosphere and is frequently used in many sciences such as climatology, hydrology, agriculture, ecology, etc. LST time series data have usually deficient, missing and unacceptable data caused by the presence of clouds in images, presence of dust in atmosphere and sensor failure. In this study, Singular Spectrum Analysis (SSA) algorithm was used to resolve the problem of missing and outlier data caused by cloud cover. The region studied in the present research included an image frame of MODIS with horizontal number 22 and vertical number 05 (h22v05). This image involved a large part of Iran and Turkmenistan and Caspian Sea. In this study, MODIS LST sensor (MOD11A1) was used during 2015 with 1×1 Km spatial resolution and day/night LST data (daily temporal resolution). The results of the data quality showed that cloud cover caused 36.37% of missing data in the studied time series with 730 day/night LST images. Further, the results of SSA algorithm in reconstruction of LST images indicated the Root Mean Square Error (RMSE) of 2.95 K between the original and reconstructed data in LST time series in the study region. In general, the findings showed that SSA algorithm using spatio-temporal interpolation in LST time series can be effectively used to resolve the problem of missing data caused by cloud cover.

The objective of this research is to develop an experimental-theoretical analysis about the influence of the cooling medium and the geometry of the welding bead profile in fatigue life and associated parameters with structural integrity of welded joints. A welded joint with cruciform geometry is considered using SMAW, plates in structural steel ASTM A36 HR of 8 mm of thickness and E6013 electrode input. A three-dimensional computational model of the cruciform joint was created using the finite element method. For this model, the surface undulation of the cord and differentiation in the mechanical properties of the fusion zone were considered, the heat-affected zone (HAZ) and base material, respectively. In addition, an initial residual stress field which was established experimentally was considered. The results were a set of analytical expressions for the weld magnification factor Mk. It was found that values for the latter decrease markedly in function of the intensity of the cooling medium used in the post welding cooling phase, mainly due to the effect of the residual compressive stresses. The obtained models of behavior of the weld magnification factor are compared with the results from other researchers with some small differences, mainly due to the inclusion of the cooling effect of the post weld and the variation of the leg of the weld bead. The obtained analytical equations in the present research for Mk can be used in management models of life and structural integrity for this type of welded joint.

Joining of aluminium alloys to steels has been extensively studied, especially in the automotive sector. However, aluminium alloys are known to be difficult to join with steels when methods involving fusion welding are used because of hot cracking problem. Hence, a high strength joint between these dissimilar metals would be of benefit especially in reducing the weight of products. In this work the torch brazing method was applied to join AR500 steel with AA7075 aluminium alloy using Al-Si-Zn base filler metal at various flame times. The effect of the brazing work on the intermetallic phase formation and the mechanical strength of the joints were investigated. In this work, the maximum shear load obtained was 6460 N and the presence of the intermetallic phases had reduced the shear strength of the brazed joints. However, the torch brazing process using Al-Si-Zn filler metal had successfully facilitated the joining of these dissimilar metals.

We herein described an investigation of a theory, which describes the energies of neutrinos and the source of neutrino oscillations. A series of experiments were conducted to show evidences of the existence a neutrino mass. We also applied theories to explain the reason for the extremely small energy of a neutrino, mainly by employing a vacuum-derived superconducting energy gap from the Bardeen–Cooper–Schrieffer ground state. Moreover, we succeeded in obtaining the transition probabilities of neutrinos’ flavors (i.e., in terms of neutrino oscillation). We focused on the fact that up- and down-quantized space pairs combine by the Lorentz forces, undertake Bose-Einstein condensation, and then create a superconducting energy gap at the energy level of the vacuum with quantum mechanics fluctuation. Eventually, the superconducting energy gap vanishes to form a real body of the neutrino. Furthermore, assuming that the speed of the neutrino is near the speed of light and exhibits Planck’s blackbody emissions, we derived many-body interactions of neutrinos and applied them in Fermi’s golden rule. As a result, the neutrino energy we calculated agreed well within the realms of the experimental results. The calculated transition probabilities of neutrino’s flavor also explain the experiment results very well.

Kinect is a device that has been widely used in many areas since it was released in 2010. Kinect SDK was announced in 2011 and used in many other areas than its original purpose, which was a controller for gaming. In particular, it has been used by a number of artists in digital media art since it is inexpensive and has a fast recognition rate. However, there is a problem. Kinect create 3D coordinates with a single 2D RGB image for x, y value - single depth image for z value. And this creates a significant limitation on the installation for interactivity of media art. Because the Cartesian XY coordinate and the spherical Z coordinate system are used in combination, depth error depending on the distance is generated, which makes real-time rotation recognition and coordinate correction difficult above coordinate system. This paper proposes a real-time calibration method of Kinect recognition range expansion for useful application in the digital media art area. The proposed method can recognize the viewer accurately by calibrating a coordinate in any direction in front of the viewer. 3,400 datasets witch acquire from experiment were measured as five stances: the 1m attention stance, 1m hands-up stance, 2m attention stance, 2m hands-up stance, and 2m hands-half-up stance, which were taken and recorded every 0.5 sec. The experimental results showed that the accuracy rate was improved about 11.5% compared with front measurement data according to Kinect reference installation method.

Objectives: The current study aimed to compare the adaptation of the restored class-I cavities with two self-etch adhesives bonded to two resin composite using cross-polarization optical coherence tomography (CP-OCT). Materials and Methods: Cylindrical class-I cavities were prepared on twenty, extracted human premolars. Two self-etch adhesives; Clearfil SE bond 2 (SE; Kuraray Noritake Dental, Japan) and Bond Force (Palfique Bond) adhesive (PL; Tokuyama Dental, Japan) were used in this study that were bonded to either resin composites materials; Herculite XRV microhybrid dental composite (HRV; Kerr, Italy) or Estelite Alpha composite (ESA; Tokuyama Dental, Japan). The specimens were divided into four groups (n=5); SE-HRV, SE-ESA, PL-HRV and PL-ESA. All specimens were varnished and stored in distilled water for 24h. Then, they were submerged in a contrasting medium. After that, all groups were optically imaged under CP-OCT at every 250 µm interval distance. Later, image binarization and gap quantification were carried out using Image analysis software. Result: There was a significant difference between all the groups except between SE-ESA and PL-ESA (p = 0.51). The highest median gap % was seen in PL-HRV group followed by SE-ESA, PL-ESA and SE-HRV. Conclusion: Other than composite filler loading and adhesive formula, the interactions of the adhesive and composite copolymers have great influence on composite adaptation.

Despite a global push in the development and implementation of widespread alternative energy use, significant disparities exist across given nation-states. These disparities reflect both technical and economic factors, as well as the social, political, and ecological gaps between how communities see energy development and national/global policy goals. Known as the “local-national gap,” many nations struggle with fostering meaningful conversations about the role of alternative energy technologies within communities. Mitigation of this problem first requires understanding the distribution of existing alternative energy technologies at the local level of policymaking. Using the State of Georgia, U.S.A. as a case study, we present a model for analyzing how existing adoption trends enable/limit conversation at the scale of local governance (i.e., county governments). Leveraging existing work on the Gini Coefficient as a metric for measuring energy inequity, we argue these tools can be applied to analyze where gaps exist in ongoing solar adoption trends. As we demonstrate, communities that adopt solar tend to be concentrated in a few counties, indicating existing conversations are limited to a circumscribed set of social networks. This information and the model we demonstrate can enable focused qualitative analyses of existing solar trends, not only amongst high-adoption areas but within communities where little to no adoption has occurred.

The effects of transcranial magnetic stimulations (TMS) show that the human brain is impacted by some magnetic fields (EMFs). Moreover, after a delay, it produces potentials that reveal a subsequent processing of this impact. The human brain might also be sensitive to very weak magnetic fields of extremely low frequencies (vwEMFelf). Namely, to the vwEMelf produced by the brain of other persons when they process visual stimuli. In effect, two studies report that the event-related brain potentials (ERPs) that are evoked by presenting a picture to a participant can be modulated by simultaneously presenting a picture to a partner. To confirm it here, we followed most of the methods of these studies. We recorded the ERPs evoked by presenting, at each trial, the photograph of a face. Simultaneously and, most importantly, privately, we presented a partner with the same or with a different face photograph. ERPs of participants were found to depend on that sameness (p0.001), unbeknownst to them. These joint processing effects (JPEs), confirm a sensitivity of the human brain to the vwEMFelf produced by other brains.

Recent times have witnessed an increasing number of countries and private firms pledging carbon neutrality by mid-century. Whilst representing a significant improvement in intentions to tackle climate change, such pledges lack substance and structure. For instance, individual pledges lack coordination and aggregation among peers, while strategies and measures to achieve ambitious targets are largely absent. Moreover, current disagreements obstructing progress in international climate change negotiations further undermine the reliability of carbon neutrality objectives. Effective international policies are needed to foster aggregate mitigation ambitions and the creation of adequate supporting mechanisms. This theoretical paper describes a governance innovation aimed at overcoming such shortfalls and disagreements through a unifying yet customizable pathway towards carbon neutrality. It does so by first outlining a political governance framework based on a climate club interpretation of Article 6 of the Paris Agreement. Secondly, it proposes carbon emission mitigation effort sharing on a per capita basis to ensure efficiency, equity and political feasibility. Thirdly, this paper describes how the supply of certified mitigations of carbon emissions required to satisfy effort sharing-based demand can be assetized as carbon credits by operationalizing Article 6 as a joint certification mechanism. The resulting governance architecture for managing demand and supply of mitigations shifts efforts to tackle climate change from a ‘problem-driven’ cost approach to ‘opportunity-driven’ value creation pathways towards carbon neutrality.

The main purpose of this paper is to present a comprehensive view of the application mathematical models in the designing and implementing SSCM beside to solving problems and making decision. The research questions are: what mathematical models are used for designing and implementing sustainable supply chain management, how to use them, which industries implemented in, what modules of SSCM depth in and finally finding the gaps of researches. The methodology of research is Systematic Literature review through peer review papers which are published in high ranking journals. In this paper, First, we search all papers through scientific data bases like Scopus, science direct, MDPI, Springer, Google Scholar, then, screening papers based on the criteria such as subject of paper, journals impact factor which is published in-should be peer review journal- and relative content of the papers. Finally, we selected 245 papers with three steps screening through 2806 papers that they have enough quality and relative to our research goals for context analysis. Through context analysis, first we categorized the information of the papers and drew the current situation of researches in the framework of our topic. Then, we evaluate and compare the goals of sustainability and current situation and found the gapes, then, offered new suggestions like implementing SSCMs models in pollutant industries like casting industry, Heavy industry, coal Industry and so on. On the other hand, there are gaps in researches in some modules of SSCM such as packaging, designing products, etc.

Over the last three decades, special economic zones (SEZs) have given new impetus to the ever-growing export-oriented industrialization in developing countries. Where various economies have benefited from SEZs, many zones have ended up becoming enclaves with trifling advantage. The SEZs in Pakistan have experienced the same fate and failed to contribute to exports, employment and creating linkages with the domestic economy. Recently under China Pakistan Economic Corridor (CPEC), SEZs are proposed to be set up in Pakistan; with a hope to fuel the stuttering economy. However, it is pertinent to first understand the local context and device policies considering stakeholders' perspectives. This study aims to identify the factors for the successful implementation of SEZs derived from the regional context of Pakistan. In-depth interviews are conducted from most relevant stakeholders, who have been involved in the development of SEZs. The results pointed towards the removal of political influence over zones and government taking the lead role in deciding the types of industry to be invited in these zones. Each zone should have a clear vision of development based on its regional advantage. The zone promotions should be based on competitiveness rather than fiscal incentives. Joint ventures and PPP to be encouraged inside the zones for sustainable operations.

Based on 2010, 2013 and 2015 CGSS data, the impact of Internet use and social capital on the income gap among farmers in the past five years is assessed at three time points using the OLS method and a quantile regression method. The study finds that (1) the income gap among farmers increases continuously in the five-year period, while Internet use plays a positive impact on farmers’ income growth in all five quartiles; the coefficient differences are all significantly negative, indicating that Internet use plays a positive role in alleviating the income gap between high-income and low-income farmer subgroups, and (2) social capital plays a positive role in moderating the income gap among farmers and that Internet use by farmers expands the boundary of social capital, which in turn increases the income level of and alleviates the income gap among farmers.

Enforcement of animal welfare statutes are the primary protection given for the maintenance of animal welfare and prevention of cruelty. It is speculated that animal law enforcement in Australia has a number of weakness in the enforcement model. These weaknesses create a gap between the goals of animal law enforcement and the reality of the animal law justice system. This gap is defined as the ‘enforcement gap’. This paper identifies and investigates the causes of this gap. The hypothesized causes discussed are (1) the impact the public can have on reporting animal cruelty, (2) the reliance on charitable organizations as enforcement bodies, (3) the inconsistencies in animal welfare legislation, and (4) the role of the sentencing courts. Thus, the causes of the enforcement gap are multifactorial; derived from all stages of the enforcement process. Further research is needed to investigate the concepts raised in this paper. However, it is likely that a combination of structural change to enforcement agencies, legislative reform and public education is required to reduce the enforcement gap.

The electronic structure and some of its derived properties of Li2CaGeO4 compound have been investigated. The calculations have been performed using the full-potential linearized augmented plane wave plus local orbitals method and ultra-soft pseudo-potentials . The optimized lattice parameters are found to be ingood accord with experiment. Features such as bulk modulus and its pressure derivative, electronic band structure and density of states are reported. The elastic anisotropy of the crystal is discussed and visualized. Moreover, the optical properties reveal that Li2CaGeO4 compound are suitable candidates for optoelectronic devices in the visible and ultraviolet (UV) regions.

A good optical quality crystal of 2-aminopyridine (2AP) metal complex crystals was grown by slow evaporation technique at room temperature. The transparent and defect less bulk size of 2-aminopyridine potassium dihydrogen orthophosphate metal complex crystals have been grown by solution growth method. The molecular structure and morphology of grown crystals was drawn and planes are indexed using WINXMORPH software. A optical absorption spectrum, the UV cut-off wavelength, Band gap (Eg), Reflectance (R), Refractive Index (n), Extinction coefficient (K) and Electrical susceptibility (χc) are calculated for 2AP metal complex crystals.

Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been found to be involved in multiple pathophysiological states from cancer to cardiovascular disease. Studies over the last 60 years have demonstrated the utility of altering GJ signaling pathways in experimental models, which has led to them being attractive targets for therapeutic intervention. A number of different mechanisms have been proposed to regulate GJ signaling, including channel blocking, enhancing channel open state, and disrupting protein-protein interactions. The primary mechanism for this has been through the design of numerous peptides as therapeutics, that are either currently in early development or are in various stages of clinical trials. Despite over 25 years of research into connexin targeting peptides, the overall mechanisms of action are still poorly understood. In this overview, we discuss published connexin targeting peptides, their reported mechanisms of action and the potential for these molecules in the treatment of disease.

It is becoming clear that in addition to gap junctions, playing a role in cell-cell communication, gap junction proteins, connexins, located in cytoplasmic-compartments may have other important functions. Mitochondrial connexin 43 (Cx43) is increased after ischemic preconditioning and has been suggested to play a protective role in the heart. How Cx43 traffics to the mitochondria and the interactions of mitochondria with other Cx43-containing structures are unknown. In this study, immunocytochemical, super-resolution and transmission electron microscopy were used to detect cytoplasmic Cx43-containing structure and to demonstrate their interactions with other cytoplasmic organelles. The most prominent cytoplasmic Cx43-containing structures, annular gap junctions, were demonstrated to form intimate associations with lysosomes as well as with mitochondria. Surprisingly, the frequency of associations between mitochondria and annular gap junctions was greater than that between lysosomes and annular gap junctions. The benefits of annular gap junction/mitochondrial associations are not known. However, it is tempting to suggest that the contact between annular gap junction vesicles and mitochondria facilitates Cx43 deliver to the mitochondria. Furthermore, it points to the need for investigating trafficking of Cx43 to cytoplasmic compartments and annular gap junction as more than only a vesicle destined for degradation.

A new strategy to nanoengineer gold/fluorocarbon multilayer (ML) nanostructures is reported. We have investigated the morphological changes occuring at the metal-polymer interface in multilayer structures with varying volume fraction of gold (Au) and the kinetic growth aspect of the microscale properties of nano-sized Au in plasma polymer fluorocarbon (PPFC). Investigations were carried out at various temperatures and annealing time by means of grazing incidence small-angle and wide-angle X-ray scattering (GISAXS and GIWAXS). We have fabricated a series of multilayers with variying volume fraction (0.12, 0.27, 0.38) of Au and bilayer periodicity in ML structure. They show an interesting granular structure consisting of nearly spherical shaped nanoparticles within the polymer layer. The nanoparticle (NP) morphology changes due to the collective effects of NPs diffusion within ensembles in the in-plane vicinity and inter-layer with increasing temperature. The in-plane NPs size distinctly increases (from 1.9 to 4 nm) with increasing temperature. The NPs become more spherical thus reducing the surface energy. Linear growth of NPs with temperature and time shows diffusion-controled growth of NPs in the ML structure. The structural stability of the multilayer is controlled by the volume ratio of the metal in polymer. At room temperature UV-Vis shows a blueshift of the plasmon peak from 560 nm in ML Au/PTFE_1 to 437 nm in Au/PTFE_3. We have identified the fabrication and post-deposition annealing conditions to limit the Local Surface Plasmon resonance (LSPR) shift (from 〖∆λ〗_LSPR=180 nm (Au/PTFE_1) to 〖∆λ〗_LSPR=67 nm (Au/PTFE_3 ML)) and their optical response over a wide visible wavelength range. A variation in the dielectric constant of the polymer in precence of varying Au inclusion is found to be the main factor affecting the LSPR frequency. Our finding may provide insights in Nano engineering ML structure can be useful to systematically control the growth of NPs in polymer matrix.

Recently, the demand for electric vehicle is increasing worldwide due to eco-friendly policies and stricter emission regulations. As a traction motor for electric vehicle, interior permanent magnet synchronous motors are mainly used. For the design of the interior permanent magnet synchronous motor, the magnetic equivalent circuit method, which is a method of lumped constant circuit, and the finite element method, which is a method of distributed constant circuit, mainly are used. Magnetic equivalent circuit method is useful for simple design through fast and intuitive parameters, but it cannot derive the distribution of magnetic field. The finite element method can derive an accurate magnetic field distribution, but it takes a long time to analyze and it is difficult to analyze intuitive design parameters. In this paper, magnetic equivalent circuit method and Carter coefficient are mixed for rotor structure design. This design method will be called the hybrid magnetic equivalent circuit method. Intuitive design parameters are derived through this hybrid magnetic equivalent circuit method. We will derive the Air gap flux density distribution according to rotor shape, no-load induced voltage, and cogging torque, and compare and verify it with the finite element method.

This paper discusses the tectonics of the St. Peter and St. Paul Archipelago (SPSPA) in the Equato-rial Atlantic Ocean, based on the joint-system geometry which show a North-South shorten-ing/transpressional uplift tectonism, is active leading to exhumation of the sub-oceanic mantle. These islets are the summits of a sigmoidal submarine ridge formed by mantle ultramafic rocks. The ridge is crossed by the principal transform deformation zone of the northern transform fault of the St. Paul Multifault System. The South flank ridge exposes serpentinized mantle perido-tites, while the North flank exposes strongly deformed/fractured ultramylonites, recording duc-tile and brittle deformation at lithospheric conditions. The SPSPA show multiple joint systems cutting mylonitic foliation of the exposed rocks, forming three main families: high-angle paral-lel joints of tectonic origin, serpentinization-related joints with random direction and load-release low-angle parallel joints. The tectonic joints show an average direction of N31°E and N28°W, forming a conjugate system with a N1ºW compression axes, coherent with a trans-pressive stress field. Accordingly, the earthquakes focal mechanism close to the islets also shows N-S compression. The previously reported active uplift with an average rate of 1.5 mm/year and the directions of the joint system here reported agreeing with a present-day active N-S compres-sive field at a high angle with the direction of the transform fault.

Angiogenesis, the sprout and growth of new blood vessels from existing vasculature, is an important process of tumor development for the supply of oxygen and nutrition to cancer cells. Endothelial cell is a critical player in angiogenic process by modulating cell proliferation, cell motility, and cell morphology in the response to pro-angiogenic factors and environments provided by tumor and cancer cells. Recent in vivo and in vitro studies have revealed that gap junction of endothelial cells also participates in the promotion of angiogenesis. Pro-angiogenic factors modulate gap junction function and connexins expression in endothelial cells, whereas endothelial connexins involve in angiogenic tube formation and cell migration of endothelial cells via both gap junction channel function dependent or independent mechanisms. In particular, connexin might have the potential to regulate cell mechanics such as cell morphology, cell migration, and cellular stiffness that are dynamically changed during angiogenic processes. Here, we review the implication for endothelial gap junction and cellular mechanics in vascular angiogenesis.

High purity TiO2 and CuO powders were synthesized by the Pechini method, an inexpensive and easy-to-implement procedure to synthetize metal oxides. The variables of synthesis were the ethylene glycol:citric acid molar ratio and the pH. High reproducibility of the anatase and tenorite phase was obtained for all synthesis routes. The degree of purity of the powders was confirmed by XRD, FTIR, UV-vis absorption and XPS spectra. SEM and TEM images revealed the powders are composed by micrometer grains that can have a spherical shape (only in the TiO2) or formed by a non-compacted nanocrystalline conglomerate. FTIR spectra only vibrational modes associated to the TiO2 or CuO with a nanoparticle behavior. UV-vis absorption spectra revealed the values of maximum absorbance percentage of both systems are reached in the ultraviolet region, with percentages above 83 % throughout the entire visible light spectrum for the CuO system, a relevant result for solar cell applications. Finally, XPS experiments allow the observation of the valence bands and the calculation of the energy bands of all oxides.

In recent years, the class of metal-organic framework (MOF) materials emerged. These materials' unique properties can be assigned to their structure, containing inorganic nodes connected with organic linkers. Due to their porosity and flexibility, MOFs have become suitable for various energy-related applications, including gas storage, hydrogen production and heterogeneous catalysis, and photocatalysis. Using DFT+U calculations, we show that the substitution of metal centers in inorganic nodes and the strain engineering of UiO-66 alters the electronic and optical properties of this material. We show that applying mechanical strain on UiO-66 enables the control of absorption coefficient in the UV-Vis spectrum and the photocatalytic processes' selectivity when reactants for several photocatalytic processes are present. The presented findings could lead to general strategies for designing novel MOFs for sustainable energy conversion applications.

Introduction: During mixed dentition period, the growth and development process of dentocraniofacial complex occurs, with temporomandibular joint as one of its centers of growth. The condition of temporomandibular joint can be seen from its condylar head shape; therefore, it is essential to understand the normal morphology of condylar head during mixed dentition period. Objective: this research aims to view the general morphology of condylar head during mixed dentition period. Method: Samples of panoramic radiographs were collected from Ma-ranatha Dental Hospital, Bandung, Indonesia. It consists of 70 male and 70 female subjects, di-vided into three groups according to their phase of mixed dentition period. Shape of subjects' condylar heads was determined by analyzing and comparing the tracing results of condyle in panoramic radiograph. Result: Study showed in first transitional period of mixed dentition, condylar head shape is dominated by round, as growth and development go on, the domination of condylar head shape is changed into convex on second transitional period. Conclusion: Mostly condylar head shape morphology during mixed dentition period is round-headed in first transitional and inter-transitional period, and convex-headed in second transitional period.

This study aims to explore the possibility of estimating a multitude of kinematic and dynamic quantities using subject-specific musculoskeletal models in real-time. The framework was designed to operate with marker-based and inertial measurement units enabling extensions far beyond dedicated motion capture laboratories. We present the technical details for calculating the kinematics, generalized forces, muscle forces, joint reaction loads, and predicting ground reaction wrenches during walking. Emphasis was given to reduce computational latency while maintaining accuracy as compared to the offline counterpart. Notably, we highlight the influence of adequate filtering and differentiation under noisy conditions and its importance for consequent dynamic calculations. Real-time estimates of the joint moments, muscle forces, and reaction loads closely resemble OpenSim's offline analyses. Model-based estimation of ground reaction wrenches demonstrates that even a small error can negatively affect other estimated quantities. An application of the developed system is demonstrated in the context of rehabilitation and gait retraining. We expect that such a system will find numerous applications in laboratory settings and outdoor conditions with the advent of predicting or sensing environment interactions. Therefore, we hope that this open-source framework will be a significant milestone for solving this grand challenge.

The purpose of this paper is to demonstrate the existence of an artificial magnetic monopole and to introduce new electromagnetic equations by altering an electric field and a magnetic field vectors.As a principle device, a cylindrical condenser is prepared, and a superconducting loop is inserted into it. By this conduction, radial electric fields take a role as the centripetal force and both counterclockwise and clockwise motions are induced. As a result, a stationery wave is formed in which the nodes take a part in creating a monopole as follows.First, employing the Lorentz conservations and because node of the stationary wave has no phases, the momentum k and the vector potential A vanish and instead a magnetic potential appears in order to maintain the Lorentz conservation. This magnetic potential has relationship with an electric potential, and thus consequently, a dependent relationship is obtained between an electric field and a magnetic field vectors. Using this conclusive dependent relationship, we can derive new Maxwell equation assembly which are created by altering the electric field and the magnetic field vectors. In this process, we derive a divergent equation of magnetic fields which is not zero, i.e., the existence of a magnetic monopole. Employing these newly derived Maxwell equation, an electromagnetic wave is derived whose speed is the same as one the existing Maxwell equations provide. As a monopole configuration, this paper discusses the energy gap of the vacuum, which is a result of the Dirac equation and describes a monopole as pairs between two Cooper pairs (i.e. four electrons) whose interaction is a photon. As mentioned, because the total momenta and phases are zero, this paper defines the wave function as the Dirac function and demonstrate the condensation, employing the Bloch’s theorem. Moreover, using the macroscopic basic equations, we retrace the creation of the divergent magnetic field in view of macroscopic phenomenon., which provides results in this paper.In Result section in this paper, we succeeded in demonstrating the distribution of the divergent magnetic field of monopole in terms of both microscopic and macroscopic scales. Furthermore, Discussion section describes properties a magnetic monopole should follow.

Compressive sensing originates in the field of signal processing and has recently become a topic of energy-efficient data gathering in wireless sensor networks. In this paper, we propose an energy efficient distributed compressive sensing solution for sensor networks. Proposed solution utilizes sparsity distribution of signals to group sensor nodes into several coalitions and then implements localized compressive sensing inside coalitions. This solution improves data-gathering performance in terms of both data accuracy and energy consumption. The approach curbs both data-transmission costs and number of measurements. Coalition-based data gathering cuts transmission cost, and the number of measurements is reduced by scheduling sensor nodes and adjusting their sampling frequency. Our simulation showed that our approach enhances network performance by minimizing energy cost and improving data accuracy.

Trace metals can enter some natural regions with low human disturbance from atmospheric circulation, but little information is available regarding how the canopy can retained trace metals. Therefore, a representative sub-alpine spruce plantation was selected to investigate the net throughfall fluxes of eight trace metals (Fe, Mn, Cu, Zn, Al, Pb, Cd and Cr) of closed canopy and gap-edge canopy from August 2015 to July 2016. Over a one-year observational period, the annual fluxes of Al, Zn, Fe, Mn, Cu, Cd, Cr and Pb were 7.29 kg·ha^-1, 2.30 kg·ha^-1, 7.02 kg·ha^-1, 0.16 kg·ha^-1, 0.19 kg·ha^-1, 0.06 kg·ha^-1, 0.56 kg·ha^-1 and 0.24 kg·ha^-1, respectively, in the deposited precipitation. The annual net throughfall fluxes of these trace metals were 1.73 kg·ha^-1, 0.9 kg·ha^-1, 1.68kg·ha^-1, -0.032 kg·ha^-1, 0.04 kg·ha^-1, 0.018 kg·ha^-1, 0.093 kg·ha^-1 and 0.087kg·ha^-1, respectively, in the gap-edge canopy and -1.6 kg·ha^-1, 1.13 kg·ha^-1, 1.65 kg·ha^-1, -0.10 kg·ha^-1, 0.05 kg·ha^-1, 0.03 kg·ha^-1, 0.26 kg·ha^-1 and 0.15 kg·ha^-1, respectively, in the closed canopy. The closed canopy displayed a greater filter effect on the trace metals from precipitation than did the gap-edge canopy in the sub-alpine forest. In the rainy season, the net filtering ratio of trace metals ranged from -66%-89% in the closed canopy and from -52% to 25% in the gap-edge canopy. However, the net filtering ratio of all trace metals was greater than 50% in the closed canopy in the snowy season. Therefore, the results suggested that the most trace metals moving through the forest canopy are taken up rather than by rainfall leaching; moreover, the closed canopy can efficiently take up trace metals in the snowy season.

This study analyzes the academic performance of students from an official school in Bogotá (Colombia) who had asymmetric access to Information and Communication Technologies during the first year of the Covid-19 pandemic. The Classical Linear Regression Model is employed using data from a survey of a representative group of students in the year 2020. Results show technological gaps between students that are associated with asymmetric academic performance against students with limited or null access to the Internet and electronic devices. Results also show that, among students with permanent access to the Internet, women have better scores compared to men’s scores, which implies that women can achieve better academic results than men in virtual education. It is also noted that the sole access to an electronic device does not guarantee good academic achievements if there is no full access to the Internet, and if ICT-use skills have not been developed.

Keyhole laser beam welding (LBW) of stainless steel sheets with a gap in between is numerically simulated with a three-dimensional, transient multi-physical model for laser material processing. At first, the model’s ability to reproduce experimental results on a relatively coarse computational mesh within reasonable computing time, so as to serve as process optimization tool, is presented. An example of process optimization, where a given set of weld seam quality criteria is fulfilled by iteratively optimizing a secondary laser beam, is shown. The relatively coarse mesh, in combination with a good model calibration to the experimental conditions, allows for sufficiently fast simulations to use this approach for optimization tasks. Finally, using a finer spatial and temporal discretization, the dynamic processes in the vicinity of the keyhole leading to the formation of pores are investigated. The physical phenomena predicted by the simulation are coherent with experimental observations found in literature.

Three ternary mixtures composed by choline chloride (ChCl), ethylene glycol (EG) and a second hydrogen bond donor (HBD) as ethanol (A), 2-propanol (B), and glycerol (C) were studied in terms of composition related to the band gap energy (BGE). A Design of Experiments (DoE) approach, and in particular a Simple Lattice three-components design, was employed for determining the variation of the BGE upon the composition of each system. UV-VIS analysis and subsequent Tauc plot methodology provided the data requested from the DoE and multivariate statistical analysis revealed a drop of the BGE in correspondence to specific binary compositions for systems A and B. In particular, a BGE of 3.85 eV was registered for the mixtures ChCl/EtOH (1:1), and ChCl/2-propanol (1:1), which represents one of the lowest values ever observed for these systems.

Despite gender equality being present in the social and political sphere, we still encounter aspects that are characteristic of sexism. Such aspects impact upon gender inequality and different types of violence towards women. The present article aims to examine the behaviour of adolescents from Huelva with regards to ambivalent sexism towards women on social networks and their influence on health. Further, we seek to uncover adolescent’s perceptions with regards to gender differences in the use of social networks, the relationship between sexism and women's emotional well-being was observed. The study sample was formed by young people aged between 14 and 16 years who were residing in rural and urban zones in the south of Spain. A mixed methods approach was taken. At a quantitative level, a sample of 400 young people was recruited. These were administered a questionnaire about sexism which was composed of two scales and has been validated at a national and international level. At a qualitative level, the study counted on 33 young people who participated in in-depth discussions via interviews and discussion groups. The results showed that sexism emerges in adolescence in the analysed sample from the south of Spain. This favoured a digital gender gap and was reinforced through social networks such as Instagram and Snapchat. Rising awareness and a critical view of the aforementioned sexism was shown on the behalf of females, particularly those from urban backgrounds.

Many countries have been facing the problem of bank insolvency across the globe. Asset deterioration is one of the main reasons for insolvency of banks. The objective of the paper is to ascertain the determinants of nonperforming loans (NPLs) in the banking sector of Pakistan for the period 2006-16. Other than the bank specific and macro variables proposed by the literature, the roles of weighted maturity and output gap are for the first time examined. We find significant impact of output gap on NPLs however weighted maturity has insignificant role in shaping the future NPLs. Bank specific drivers of NPLs include bank size and capital adequacy ratio.

Alpine forest gaps can distribute snowfall, solar radiation and rainfall, thus inducing a heterogeneous hydrothermal microenvironment between the inside and outside areas of forest gaps. Additionally, the characteristics of the heterogeneous microenvironment could vary greatly across the gap location properties during winter and the growing season. To determine the response of total phenol loss (TPL) from the litter to alpine forest gap disturbance during decomposition, we conducted a field litterbag experiment within a representative fir (Abies faxoniana Rehd.) forest based on the gap location properties. The TPL and abundances of fungi and bacteria from two typical shrub species (willow, Salix paraplesia Schneid., and bamboo, Fargesia nitida (Mitford) Keng f.) were measured during the following periods over two years: snow formation (SF), snow cover (SC) snow melting (ST), the early growing season (EG) and the later growing season (LG). At the end of the study, we found that the snow cover depth, frequencies of the freeze-thaw cycle and the fungal copy g-1 to bacterial copy g-1 ratio had significant effects on the litter TPL. The abundances of fungi and bacteria decreased from the gap center to the closed canopy during the two SF, SC, ST and LG periods and reversed during the two EG periods. The TPL closely followed the same trend as the microbial abundance during the first year of incubation. In addition, both species had larger TPLs in the gap center during the first winter, first year and entire two years. These findings suggest that alpine forest gap formation accelerates litter TPL and plays a dual role during specific critical periods by distributing abiotic and biotic factors directly and indirectly. In conclusion, reduced snow cover depth and duration during winter warming under current climate change scenarios or as gaps vanish may slow litter TPL in alpine biomes.

Recent studies suggest that the developmental curves in adolescence, related to the development of executive functions, could be fitted to a non-linear trajectory of development with progressions and retrogressions. Therefore, the present study proposes to analyze the pattern of development in Perceptual Inhibition (PI), considering all stages of adolescence (early, middle, and late) in intervals of one year. To this aim, we worked with a sample of 275 participants between 10 and 25 years, who performed a joint visual and search task (to measure PI). We have fitted exGaussian functions to the probability distributions of the mean response time across the sample and performed a covariance analysis (ANCOVA). The results showed that the 10- to 13-year-old groups performed similarly in the task and differ from the 14- to 19-year-old participants. We found significant differences between the older group and all the rest of the groups. We discuss the important changes that can be observed in relation to the nonlinear trajectory of development that would show the PI during adolescence.

Background and Objectives: Sports medicine, orthopaedic and rehabilitation physicians use gait analysis and goniometry to evaluate and diagnose patients with neuro-musculo-skeletal diseases. Goniometry is a measuring method that shows the joint’s range of motion. Three-dimensional goniometry has been used in order to assess the patients in a kinematic manner, but they are not affordable, so, phone apps come handy to any orthopaedic or rehabilitation physician so we can have a clear image of the progress made by the patient after the rehabilitation program or should something happen and the patient cannot come to the facility, such as the Covid-19 pandemic, when some orthopaedic and most of the rehabilitation facilities have been temporarily closed. Midstance has been chosen as the moment of the gait evaluation in this paper since it has an important role in stability. The objective of this paper is to figure out if the measurements taken during midstance at the knee joint of the subjects can be statistically significant and used during usual examinations. Materials and Methods: Four groups of subjects: patients suffering from hip, knee, hip and knee osteoarthritis and a control group volunteered their participation, being asked to normally walk while their gait was recorded and uploaded into Angles App – a phone based videogoniometer. Results: Patients suffering from hip osteoarthritis have a higher knee angle on the right side than the ones suffering from knee osteoarthritis, hip and knee osteoarthritis and the control group. Female patients suffering from hip osteoarthritis also presented a more flexed knee than the ones suffering from knee osteoarthritis and the ones in the control group, the knee flexion presenting itself as a compensation mechanism. Conclusion: Video goniometry can help us make an orthopaedic, rehabilitation or neurology database for each assessment with constant updates of the evolution of the osteoarthritis patient’s treatment.

In time, osteoarthritis (OA) generates the misalignment of the affected joint structures. However, due to the nature of bipedal gait, OA in the lower limb can also cause pathological gait patterns, which can generate instability and falls, with great consequence, especially in the aged population. With goniometry used to evaluate the range of motion of joints (ROM), we wanted to evaluate how gender impacts gait dynamics in OA patients. For this study we have compared 106 OA patients (male=32, female=74) to age matched controls. All participants had their right leg as dominant. Video recording of normal gait was analysed with a digital goniometry tool phone application, and the knee’s ROM was measured in midstance and midswing of the gait. During midstance, significant extension and flexion of the knee excursion have been observed in both males and females. During midswing, knee OA presents more differences, whereas subjects with hip and knee OA present changes on the dominant knee. Midstance changes suggest that the knee’s joint degenerative changes can be linked to hip OA secondary changes. Midswing changes in lower limb OA suggest a connection to the activities of daily life. Gender differences generated by OA must furthermore be studied in both lower limbs so that the best therapeutic approach can be chosen.

Intra-articular fractures are a major cause of post-traumatic osteoarthritis (PTOA). Despite adequate surgical treatment, the long-term risk for PTOA is high. Previous studies reported that joint injuries initiate an inflammatory cascade characterized by elevation of synovial pro-inflammatory cytokines, which can lead to cartilage degradation and PTOA development. This review summarizes the literature on the post-injury regulation of pro-inflammatory cytokines and the markers of cartilage destruction in patients suffering from intra-articular fractures. METHODS We searched Medline, Embase, and Cochrane databases (1960–February 2020) and included studies that were performed on human participants and included control groups. Two investigators assessed the quality of the included studies using Covidence and the Newcastle-Ottawa Scale. RESULTS Based on the surveyed literature, several synovial pro-inflammatory cytokines, including interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-12p70, interferon-y, and tumor necrosis factor-α, were significantly elevated in patients suffering from intra-articular fractures compared to control. A simultaneous elevation of anti-inflammatory cytokines such as IL-10 and IL-1RA was also observed. In contrast, IL-13, CTX-II, and aggrecan concentrations did not differ significantly between the compared cohorts. CONCLUSIONS Overall, intra-articular fractures are associated with an increase in inflammation-related synovial cytokines. However, more standardized studies which focus on the ratio of pro- and anti-inflammatory cytokines at different time points are needed.

In the early 1990s, cyberfeminism emerged as an area of knowledge to discuss the connection between gender and technology. According to UNESCO, women are underrepresented in the field of science, technology, engineering, and mathematics and less than a third of women worldwide work in scientific research and development. However, this number has grown and this reality is constantly changing. In this context, using business intelligence techniques, this study analyzes data from the computer and information and communication technology market to characterize the impact of the performance of women in these areas. It is expected to show that this performance in the highlighted fields is still a challenge in Brazil.

Manual measurement of rock discontinuities is time-consuming and subjective according to the experience of the surveyor. This work proposes a three-dimensional laser scanning-based method for the semi-automatic identification of rock discontinuities. Multisite cloud scanning is performed with real-time kinematic (RTK)-assisted orientation to estimate the rock fracturing degree; then, discontinuity orientations are extracted with the man–machine interactive method or automatic method. The proposed method was applied to actual examples to illustrate its accuracy at identifying rock discontinuities. The sensitivity of the identification accuracy to different parameters was investigated.

In-depth research on the rehabilitation mechanism and motion characteristics of a rehabilitation training robot based on 4-UPUS parallel mechanism. The overall design and the working principle of each key component are explained, and the robot rehabilitation scheme is described. The static analysis and modal analysis of the robot bearing structure are carried out to verify whether the static mechanical characteristics of the mechanism meet the application requirements under working conditions.A simplified mathematical model of the six-bar linkage mechanism is established, and the kinematics of the mechanism is solved by the geometric analysis method. The motion characteristic diagram of each key point is obtained through simulation calculation. Establish the motion model of the parallel mechanism, and discuss the working space and motion performance analysis of the mechanism. The forward solution analysis of the mechanism position is carried out by using the numerical analysis method, and the three-dimensional graphics of the attitude angle and linear displacement of the reachable working space are obtained.Taking the UPUS single branch chain as the analysis object, the single open chain analysis method is used to solve the kinematics image of the corresponding surface in the working space of the mechanism, which verifies the correctness of the kinematics theoretical solution and the feasibility of simulation.The research results show that the 4-UPUS parallel mechanism rehabilitation training robot can cooperate with the ankle joint for rehabilitation training. It makes up for the single movement of the current lower limb rehabilitation robot and the unsatisfactory rehabilitation effect, and provides a reference for the practical application of the subsequent ankle joint rehabilitation robot system.

The purpose of this study was to investigate the changes in anterior knee laxity (AKL), stiffness, general joint laxity (GJL), and genu recurvatum (GR) during the menstrual cycle in female non-athletes and female athletes with normal and irregular menstrual cycles. Participants were 19 female non-athletes (eumenorrhea, n=11; oligomenorrhea, n=8) and 15 female athletes (eumenorrhea, n=8; oligomenorrhea, n=7). AKL was measured as the amount of anterior tibial displacement at 67 N - 133 N. Stiffness was calculated as change in (Δ)force/Δ anterior displacement. The Beighton method was used to evaluate the GJL. The GR was measured as the maximum angle of passive knee joint extension. AKL, stiffness, GJL, and GR were measured twice in four phases during the menstrual cycle. Stiffness was significantly higher in oligomenorrhea groups than in eumenorrhea groups, although no significant differences between menstrual cycle phases were evident in female non-athletes. GR was significantly higher in the late follicular, ovulation, and luteal phases than in the early follicular phase, although no significant differences between groups were seen in female athletes. Estradiol may affect the stiffness of the periarticular muscles in the knee, suggesting that GR in female athletes may change during the menstrual cycle.

A given problem in physics can be solved if it is well formulated. Well formulated means that it has a bijective correspondence to physical reality. Mass Gap Problem has no bijective correspondence with the physical reality and is that’s why not solvable mathematically. It can be solved in the frame of quantum mechanics by the formulation of the photon’s mass accordingly to the Planck-Einstein relation.

The financial sector, too, is developing innovative services and products that have the potential to make a more positive impact on global environmental goals. However, research sheds little light on environmental attitudes and behavioral patterns of employees in this sector. There are multiple factors promoting or inhibiting environmental behavior. Those factors may be rooted in individual or subjective norms, but also social influence and to some extent financial incentives and benefits. A survey concerning the intention to improve and actually show ‘green behavior’ was developed based on widely used acceptance models which differentiate between desirable behavior and the intention to show such behavior. Employees are predominately responsive towards environmental behavior: 20% are convinced of the need to act in a “green” and sustainable manner, only 5% are hard to win over or are not accessible at all. Financial loss or benefits combined with social motives contribute to sustainable living whereas financial benefits alone actually hinder such behavior. The study underlines the existence of a intention-behavior gap: The intention to behave sustainably is built somewhat separately from various influences. There are moderating factors like sex, age and family status that influence the decisions. This then leads to a gap between intention and actual behavior.

The aim of this study was to assess the best timing to perform arthrocentesis in the management of temporomandibular disorders with regards to conservative treatment. A systematic search based on PRISMA guidelines, including a computer search with specific keywords, reference list search, and manual search was done. Relevant articles were selected after 3 search rounds for final review based on 6 predefined inclusion criteria, followed by a round of critical appraisal. Eleven publications, including 5 randomized controlled trials and 6 prospective clinical studies informed this review. The studies were divided into 3 groups based on the timing of arthrocentesis: 1). Arthrocentesis as the initial treatment, 2). Early arthrocentesis, and 3). Late arthrocentesis. Meta-analyses compared the efficacy of improvement in mouth opening and pain reduction in the 3 groups. The results were statistically significant and favoured early arthrocentesis, followed by late arthrocentesis in terms of both improvements in mouth opening and pain reduction. All 3 groups showed improvement in mouth opening and pain reduction. We conclude that early arthrocentesis may be able to produce the best clinical results, while arthrocentesis before attempting conservative treatment may produce less favourable outcomes.

We profiled the transcriptomes of primary mouse cortical astrocytes cultured alone or co-cultured with immortalized precursor oligodendrocytes. The experimental set-up (insert systems) prevented formation of gap junction channels but allowed free exchange of the two culture media. The study complements our previously published reports that the genomic fabrics of major functional pathways in oligodendrocytes are substantially remodeled by the proximity of non-touching astrocytes. Here, we present new analysis indicating that the transcriptomic landscape of astrocytes likewise changes significantly in the proximity of non-touching oligodendrocytes. The research was stimulated by the reported transcriptomic similarity between the brains of Cx43KO and Cx32KO mice, both substantially different from that of the Cx36KO mice. Since the three connexins are expressed in different cell types (Cx43 in astrocytes, Cx32 in oligodendrocytes and Cx36 in neurons), altogether these findings support the idea of a “panglial transcriptomic syncytium” in the mouse brain. Going further, our results suggest that integration in a heterocellular tissue modulates not only the expression profile but also the expression control and networking of the genes in each cell phenotype.

The variable-length arbitrary Lagrange-Euler (ALE)-ANCF finite element, which employ nonrational interpolating polynomials, cannot exactly describe the rational cubic Bezier curves such as conic and circular curves. The rational absolute nodal coordinate formulation (RANCF) finite element, whose reference length (undeformed length) is constant, can exactly represent the rational cubic Bezier curves. A new variable-length finite element called the ALE-RANCF finite element, which is capable of accurately describe the rational cubic Bezier curves, is proposed by combining the desirable features of the ALE-ANCF and RANCF finite element. In order to control the reference length of ALE-RANCF element within a suitable range, element segmentation and merging schemes are proposed. It is demonstrated that exact geometry and mechanic is maintained after the ALE-RANCF element is divided into two shorter ones, and compared with the ALE-ANCF elements, there are smaller deviations and oscillations after two ALE-RANCF elements are merged into a longer one. Numerical examples are presented and the feasibility and advantages of the ALE-RANCF finite element are demonstrated.

Abstract: The Hanqu Joint Station of the Dingbian Oil Production Plant of Yanchang Oilfield Co., Ltd is located at the edge of the desert in northern China. the bad field conditions and strong sandstorm, the hardware of computer monitoring system of Joint Station is often damaged. At the same time, the core equipment of the joint station three-phase separator oil chamber liquid level is hard to achieve high precision constant value control, the general control algorithm is difficult to meet the control requirements.This paper proposed a design scheme of a oilfield joint station computer monitoring system based on the Siemens S7-300 PLC, the hardware of the monitoring system adopts the redundancy scheme of dual monitoring computers, dual programmable logic controllers (PLCs), and dual industrial Ethernet. The BP neural network PID control algorithm was used to realize constant value control of the oil chamber liquid level of the three-phase separator of the core equipment of the joint station，and realized high control precision. The monitoring system could well adapt to the harsh environment of the scene, and showed high reliability and efficiency.

In the sugar industry, dextran generates difficulties in the manufacturing process. Crude dextranase (EC 3.2.1.11) to eliminate dextran in sugar is an effective practice. In this study, a synthetic dextranase encoding gene of the filamentous fungus Talaromyces minioluteus, lacking its putative native signal peptide (1-20 amino acids) and the next 30 amino acids (r-TmDEX49A-ΔSP-ΔN30), was fused to the Saccharomyces cerevisiae prepro -factor (MF-2) signal sequence and expressed in Komagataella phaffii under the constitutive GAP promoter. K. phaffii DEX49A-ΔSP-ΔN30, constitutively producing and secreting the truncated dextranase was obtained. The specific activity of the truncated variant resulted nearly the same in relation to the full-length mature enzyme (900-1000 U.mg-1 of protein). At shaker scale (100 mL) in YPG medium, the enzymatic activity was 273 U.mL-1. The highest production level was achieved in a fed-batch culture (30 h) at 5 L fermenter scale using the FM21-PTM1 culture medium. The enzymatic activity in the culture supernatant reached 1614 U.mL-1 and the productivity was 53800 U.L-1.h-1 (53.8 mg.L-1.h-1), the highest reported so far for a DEX49A variant. Dextran decreased r-TmDEX49A-ΔSP-ΔN30 mobility in affinity gel electrophoresis, providing evidence of carbohydrate-protein interactions. K. phaffii DEX49A-ΔSP-ΔN30 shows great potential as a methanol-free, commercial dextranase production system.

This study aims to improve the shaft with hexagon joints to be a type not requiring welding or bolts in the static load test . In order to evaluate the bearing capacity of helical piles, two sites were selected to conduct pile installation for the field test and the pile load test. For the pile load test, the static pile load test and the dynamic pile load test were carried out, and torque was measured during pile installation for the field test to compare and analyze expected bearing capacity and thus assess the feasibility of the method for estimating the bearing capacity. The field pile load test revealed the bearing capacity of the gravity grout pile was the same or greater than 600kN in the static pile load test in accordance with AC 358 Code. The non-grout pile showed the bearing capacity the same or smaller than 600kN, suggesting gravity grouting is required. Moreover, the field pile load test was used to establish the bearing capacity equation considering the torque in pile installation, and a small number of samples were used to establish the equation which can be used as a basic data.

Characterized in biomedical terms, stretching exercises have been defined as movements applied by external and/or internal forces – to increase muscle and joint flexibility, decrease muscle stiffness, to elevate joint range of motion (ROM), to increase the length of the morpho-functional unit “muscle-tendon”, to improve joint, muscle and tendon movements, contraction and relaxa-tion. The present review examines and summarizes the initial and recent literature data related to the biomechanical, physiological and therapeutic effects of static stretching (SS) on flexibility and other physiological characteristics of the main structural and functional unit “joint-ligaments-tendon-muscle”. The healing and therapeutic effects of SS, soon combined with other rehabilitation techniques (massage, foam rolling – with and without vibrations; hot/cold therapy, etc.) are discussed in relationship to creation of individual (patient-specific) or group programs for treatment and prevention of joint injuries as well as for improving performance in sports. From a theoretical point of view, the role of SS as positively affecting the composition of the connective tissue matrix is pointed out: type I-III collagen synthesis, hyaluronic acid and glucosaminoglycans (GAGs) turnover – under influence of the transforming growth factor beta-1 (TGF-β-1). Different variables as collagen type, biochemistry, elongation and elasticity are used as molecular biomarkers. Recent studies evaluated that the static progressive stretching therapy could prevent/reduce the development of arthrogenic contractures, joint capsule fibrosis, muscle stiffness and need new clinical applications. Combined stretch techniques are proposed and ap-plied in medicine and sports, depending on their long- and short-term effects on variables such as ROM, EMG activity, muscle stiffness, etc. The results obtained are of theoretical and practical interest for development of new experimental, mathematical and computational models and creation of efficient therapeutic programs. The healing SS effects on the main structural and functional unit – “joint-ligament-tendon-muscle” need further investigations, which could clarify and evaluate benefits of SS in prophylaxis and treatment of joint injuries - in healthy and ill in-dividuals, in older adults, as compared to young, active and well-trained persons, as well as to professional athletes.

Recently Li et al (2019 Nature 572 624) discovered a new type of oxide superconductor Nd_0.8Sr_0.2NiO₂ with T_c = 14 K. To classify superconductivity in this infinite-layer nickelate experimental upper critical field, B_c2(T), and the self-field critical current densities, J_c(sf,T), reported by Li et al (2019 Nature 572 624), are analysed in assumption of s-, d-, and p-wave pairing symmetries and single- and multiple-band superconductivity. Based on deduced the ground-state superconducting energy gap, Δ(0), the London penetration depth, λ(0), the relative jump in electronic specific heat at T_c, ΔC/C, and the ratio of 2Δ(0)/k_BT_c, we conclude that Nd_0.8Sr_0.2NiO₂ is type-II high-κ weak-coupled single-band s-wave superconductor.

Backyard chickens are the most popular poultry in Bangladesh due to their production potential, and income generation. However, this farming can be a factor in zoonotic disease transmission. This study aimed to assess the knowledge, attitudes, and practices (KAP) related to biosecurity and management among backyard chicken households in Bangladesh. A cross-sectional survey was conducted among 295 households in six sub-districts of different six divisions of Bangladesh. The study used a convenient sampling technique to choose the divisions, then the districts and sub-districts. A well-structured pre-tested questionnaire was used to interview randomly selected households. In this study, most of the respondents relied on agriculture crop production (n=128) as their primary source of income, relied on scavenging for their birds’ feeding (34%), or fed their chickens whole or broken rice (32%), used tube well water (58%), used ash (38%) or sand (28%) as litter material. A significant proportion of households (40%) did not use any nest box at all. Results also showed that the most reported poultry diseases among backyard poultry farmers were Newcastle disease (49%), followed by coccidiosis (30%), fowl cholera (12%), and fowl pox (9%). In the multivariate logistic regression model, knowledge of biosecurity was associated with the household type (OR=1.4, p=0.04), knowledge of vaccination (OR=3.7, p=0.02), don’t know category (OR=4.2, p=<0.001), provision of the nest box (OR=9.5, p<0.001), training (OR=0.1, p=0.04), and air pollution (OR=0.1; p=0.04). The study found a huge knowledge gap on management and biosecurity practices present among backyard chicken farmers, which can negatively impact public health for instance in the outbreak of zoonotic diseases. Increasing farmers' biosecurity awareness through education and outreach activities could minimize the risk of disease transmission and improve both public and poultry health.

Subchondral bone loss is an important pathological feature of early-stage temporomandibular joint (TMJ) osteoarthritis (OA). Previous studies focused mainly on the bone resorption by osteoclasts in early-stage OA, but the bone formation feature has not drawn enough attention. Sema4D/Plexin-B1 is a pair of molecules expressed by osteoclast/osteoblast, which is capable of inhibiting bone formation by osteoblasts. The present study found that subchondral bone loss in early-stage TMJ OA was accompanied by up-regulated expression of Sema4D in cartilage and subchondral bone and Plexin-B1 in subchondral bone. Reducing Sema4D level could inhibit the subchondral bone loss and cartilage degeneration of early-stage TMJ OA. In vitro, results revealed that Sema4D could reduce the expression of osteocalcin (OCN) and alkaline phosphatase (ALP), and increase the migrating capability of Plexin-B1-positive osteoblasts. Our results revealed that elevated Sema4D expression in early-stage TMJ OA might decrease the bone formation activity of osteoblasts in the subchondral bone by binding to Plexin-B1 expressed by osteoblasts. Inhibiting Sema4D/Plexin-B1 signaling in the early-stage OA holds promise as a strategy for new therapeutic approaches to osteoarthritis.

Optical motion capture is a mature contemporary technique for the acquisition of motion data, alas it is non-error-free. Due to technical limitations and occlusions of markers, gaps might occur in such recordings. The article reviews various neural network architectures applied for gap filling problem in motion capture sequences within FBM framework providing the representation for body kinematic structure. The results are compared with interpolation and matrix completion methods. We found out, that for longer sequences simple linear feedforward neural networks can outperform the other, sophisticated architectures. We were also able to identify, that acceleration and monotonicity of input sequence are the parameters that have a notable impact on the obtained results.

The aim was to study alterations of bacterial communities in patients undergoing hip or knee arthroplasty to assess the impact of chlorhexidine gluconate soap decolonisation and systemic antibiotic prophylaxis. A Swedish multicentre, prospective collection of samples obtained from elective arthroplasty patients (n=83) by swabbing anterior nares, skin sites in the groin and the site of planned surgery, before and after arthroplasty surgery, was analysed by 16S rRNA (V3-V4) gene sequencing and a complementary targeted tuf gene sequencing approach to comprehensively characterise alterations in staphylococcal communities. Significant reductions in alpha diversity was detected for both bacterial (p=0.04) and staphylococcal (p=0.03) groin communities after arthroplasty surgery with significant reductions in relative Corynebacterium (p=0.001) abundance and S. hominis (p=0.01) relative staphylococcal abundance. In nares, significant reductions occurred for S. hominis (p=0.02), S. haemolyticus (p=0.02), and S. pasteuri (p=0.003) relative to other staphylococci. S. aureus colonised 35% of anterior nares before and 26% after arthroplasty surgery. S. epidermidis was the most abundant staphylococcal species at all sampling sites. No bacterial genus or staphylococcal species increased significantly after arthroplasty surgery. Application of a targeted tuf gene sequencing approach provided auxiliary staphylococcal community profiles and allowed species-level characterisation directly from low biomass clinical samples.

Connexin 43 (Cx43) is expressed in kidneys and constitutes a feedforward mechanism leading to inflammation in other tissues where they form hemichannels and gap junction channels. However, the possible functional relationship between these membrane channels and their role in damaged renal cells remains unknown. Here, analyses of ethidium uptake and thiobarbituric acid reactive species revealed that TNF-α plus IL-1β increase Cx43 hemichannel activity and oxidative stress in MES-13 cells, a cell line derived from mesangial cells. The latter also was accompanied by a reduction in gap junctional communication, whereas western blotting analysis showed a progressive increase of phosphorylated MYPT (a substrate of RhoA/ROCK) and Cx43 upon TNF-α/IL-1β treatment. Additionally, inhibition of RhoA/ROCK strongly diminished the TNF-α/IL-1β-induced activation of Cx43 hemichannels and reduction in gap junctional coupling. We propose that activation of Cx43 hemichannels and inhibition of cell coupling during pro-inflammatory conditions could contribute to oxidative stress and damage of mesangial cells via the RhoA/ROCK pathway.

Connexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both pro- and anti-tumorigenic properties, but the mechanisms underlying these characteristics are not fully understood. Tunneling nanotubes (TNTs) are long and thin membrane projections that connect cells, facilitating the exchange of not only small molecules, but also larger proteins, organelles, bacteria, and viruses. Typically, TNTs exhibit increased formation under conditions of cellular stress and are more prominent in cancer cells, where they are generally thought to be pro-metastatic and to provide growth and survival advantages. Cx43 has been described in TNTs, where it is thought to regulate small molecule diffusion through gap junctions. Here, we developed a high-fidelity CRISPR/Cas9 system to knockout (KO) Cx43. We found that loss of Cx43 expression was associated with significantly reduced TNT length and number in breast cancer cell lines. Notably, secreted factors present in conditioned medium stimulated TNTs more potently when derived from Cx43-expressing cells than from KO cells. Moreover, TNT formation was significantly induced by inhibition of several key cancer signaling pathways that both regulate Cx43 and are regulated by Cx43, including RhoA kinase (ROCK), protein kinase A (PKA), focal adhesion kinase (FAK), and p38. Intriguingly, drug-induced stimulation of TNTs was more potent in Cx43 KO cells than in wild-type cells. In conclusion, this work describes a novel non-canonical role for Cx43 in regulating TNTs, identifies key cancer signaling pathways that regulate TNTs in this setting, and provides mechanistic insight into a pro-tumorigenic role of Cx43 in cancer.

In C. elegans, gap junctions couple cells of the somatic gonad with the germline to support germ cell proliferation and gametogenesis. We previously characterized a strong loss-of-function mutation (T239I) affecting the second extracellular loop (EL2) of the somatic INX-8 hemichannel subunit. These mutant hemichannels form non-functional gap junctions with germline-expressed innexins. Here we describe the characterization of mutations that restore germ cell proliferation in the T239I EL2 mutant background. We recovered seven intragenic mutations located in diverse domains of INX-8 but not the EL domains. These second-site mutations compensate for the original channel defect to varying degrees, from nearly complete wild-type rescue, to partial rescue of germline proliferation. One suppressor mutation (E350K) supports the innexin cryo-EM structural model that the channel pore opening is surrounded by a cytoplasmic dome. Two suppressor mutations (S9L and I36N) may form leaky hemichannels that support germline proliferation but cause the demise of somatic sheath cells. Phenotypic analyses of three other suppressors reveal an equivalency in the rescue of germline proliferation and comparable delays in gametogenesis but a graded rescue of fertility. These latter mutations may be useful to probe interactions with the biochemical pathways that produce the molecules transiting through soma-germline gap junctions.

The rank-3 antisymmetric tensors which are the magnetic monopoles of SU(N) Yang-Mills gauge theory dynamics, unlike their counterparts in Maxwell’s U(1) electrodynamics, are non-vanishing, and do permit a net flux of Yang-Mills analogs to the magnetic field through closed spatial surfaces. When electric source currents of the same Yang-Mills dynamics are inverted and their fermions inserted into these Yang-Mills monopoles to create a system, this system in its unperturbed state contains exactly 3 fermions due to the monopole rank-3 and its 3 additive field strength gradient terms in covariant form. So to ensure that every fermion in this system occupies an exclusive quantum state, the Exclusion Principle is used to place each of the 3 fermions into the fundamental representation of the simple gauge group with an SU(3) symmetry. After the symmetry of the monopole is broken to make this system indivisible, the gauge bosons inside the monopole become massless, the SU(3) color symmetry of the fermions becomes exact, and a propagator is established for each fermion. The monopoles then have the same antisymmetric color singlet wavefunction as a baryon, and the field quanta of the magnetic fields fluxing through the monopole surface have the same symmetric color singlet wavefunction as a meson. Consequently, we are able to identify these fermions with colored quarks, the gauge bosons with gluons, the magnetic monopoles with baryons, and the fluxing entities with mesons, while establishing that the quarks and gluons remain confined and identifying the symmetry breaking with hadronization. Analytic tools developed along the way are then used to fill the Yang-Mills mass gap.

There is accumulating evidence that prenatal exposure to air pollution disturbs fetal growth and development, but little is known about these effects in cold climates or their season-specific or joint effects. Our objective was to assess independent and joint effects of prenatal exposure to specific air pollutants on the risk of low birth weight (LBW). We utilized the 2568 children of the Espoo Cohort Study, born between 1984 and 1990, and living in the City of Espoo. We conducted stratified analyses for births during warm and cold seasons separately. We analyzed the effect estimates using multi-pollutant Poisson regression models with risk ratio (RR) as the measure of effect. The risk of LBW was related to exposure to CO and (adjusted RR 1.44, 95% CI: 1.04-2.00) and exposure to O3 in the spring-summer season (1.82, 1.11-2.96). There was also evidence of synergistic effects between CO and O3 (relative risk due to interaction, RERI, all year 1.08, 95% CI: 0.27-4.94, spring-summer 3.97, 2.17-25.85) and PM2.5 and O3 (all year 0.72, -0.07-3.60, spring-summer 2.80, 1.36-19.88). We present new evidence of both independent and joint effects of prenatal exposure in a cold climate on the risk of LBW at low levels of air pollution.

The research problem was formulated as a question: are demand-supply shocks affecting the opening up of a negative or positive output gap? The hypothesis was formulated: demand-supply shocks have a significant impact on the opening up and deepening of the negative output gap, thereby causing real GDP to shrink or potential GDP to grow. The spatial range applies to Poland and the time period - 2008:Q1-2019:Q4. The methodology consists of three stages: the first is the decomposition of the time series using the TRAMO/SEATS on the components: seasonality, trend-cycle, irregular; the second - the decomposition of the trend-cycle component using the Hodrick-Prescott filter into two separate components; the third is the calculation of the output gap; forecast with VECM and IRF approximation. The ouput gap is in the range of - 11% to +10%. After cleaning it, the shock elements are between -2.2% and 2%. Demand-supply shocks open up and widen the negative output gap. Based on forecasts, the output gap will be positive by the end of 2022, close to 0% (optimal scenario), rising to 5% (optimistic scenario) and negative, deepening to -4% (pessimistic scenario). Two of these scenarios point to a growing risk of secular stagnation.