Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia

Thitiporn Supasitthumrong
* ORCID logo ,
Chavit Tunvirachaisakul
,
Daruj Aniwattanapong
,
Sookjaroen Tangwongchai
,
Phenphichcha Chuchuen
,
Itthipol Tawankanjanachot
,
Thiti Snabboon
,
Solaphat Hemrungrojn
,
Andre F. Carvalho
,
Michael Maes
Version 1 : Received: 28 January 2019 / Approved: 29 January 2019 / Online: 29 January 2019 (16:52:14 CET)

How to cite: Supasitthumrong, T.; Tunvirachaisakul, C.; Aniwattanapong, D.; Tangwongchai, S.; Chuchuen, P.; Tawankanjanachot, I.; Snabboon, T.; Hemrungrojn, S.; Carvalho, A.F.; Maes, M. Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia. Preprints 2019, 2019010296. https://doi.org/10.20944/preprints201901.0296.v1 Supasitthumrong, T.; Tunvirachaisakul, C.; Aniwattanapong, D.; Tangwongchai, S.; Chuchuen, P.; Tawankanjanachot, I.; Snabboon, T.; Hemrungrojn, S.; Carvalho, A.F.; Maes, M. Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia. Preprints 2019, 2019010296. https://doi.org/10.20944/preprints201901.0296.v1

Abstract

Background: The Apolipoprotein E4 (ApoE4) genotype is strongly associated with Alzheimer’s disease (AD), although the presence of the ApoE4 allele alone is not sufficient to explain AD. The pathophysiology of amnestic mild cognitive impairment (aMCI) remains unclear. This study aims to examine associations between peripheral blood biomarkers coupled with ApoE4 and episodic and semantic memory. Methods: The CERAD battery was completed and various biomarkers were assayed in 60 subjects with aMCI, 60 with AD and 62 healthy controls. Results: Deficits in semantic and episodic memory were significantly predicted by anion gap and bicarbonate, albumin and glucose coupled with Apo E4. Furthermore, these peripheral biomarkers interacted with ApoE to predict greater memory impairments. Conclusions: Peripheral blood biomarkers may interact with pathways related to ApoE4 to predict greater semantic and episodic memory impairments, thus contributing to the pathophysiology of aMCI and AD. Our data suggest that the transition from aMCI to AD could at least in some cases be associated with significant interactions between ApoE4 and those peripheral blood biomarkers.

Keywords

episodic memory, apolipoprotein, dementia, biomarkers, anion gap, inflammation

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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