Preprint Review Version 1 This version is not peer-reviewed

Connexins: Synthesis, Post-Translational Modifications and Trafficking in Health and Disease

Version 1 : Received: 19 March 2018 / Approved: 20 March 2018 / Online: 20 March 2018 (05:27:38 CET)

A peer-reviewed article of this Preprint also exists.

Aasen, T.; Johnstone, S.; Vidal-Brime, L.; Lynn, K.S.; Koval, M. Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease. Int. J. Mol. Sci. 2018, 19, 1296. Aasen, T.; Johnstone, S.; Vidal-Brime, L.; Lynn, K.S.; Koval, M. Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease. Int. J. Mol. Sci. 2018, 19, 1296.

Journal reference: Int. J. Mol. Sci. 2018, 19, 1296
DOI: 10.3390/ijms19051296

Abstract

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability and function. Here, we summarize these key regulatory events, with emphasis on how these affect their multi-functionality in health and disease.

Subject Areas

connexins; gap junctions; transcription; translation; post-translational modifications; trafficking

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