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Preprint ARTICLE | doi:10.20944/preprints202404.1285.v1

Improving the Clinical Utility of Platelet Count in Primary Care with Age- and Sex-Stratified Upper Thresholds Suggestive of an Undiagnosed Cancer: A Cohort Study Set in Primary Care in England, Canada, and Australia

Luke T. A. Mounce, Raff Calitri, Willie Hamilton, Meena Rafiq, Jon D. Emery, Vasily Giannakeas, Joanne Kotsopoulos, Sarah E. R. Bailey

Subject: Primary Health Care, Public Health And Healthcare Keywords: cancer; diagnosis; primary care; family medicine; full blood count; platelet count

Online: 19 April 2024 (14:37:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0970.v1

The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: a Bayesian Approach

Philippe R Koninckx, Anastasia Ussia, Stephan Gordts, Jörg Keckstein, Ertan Saridogan, Malzoni Mario, Assia Stepanian, António Gutierrez Setúbal, Leila Adamyan, Arnaud Wattiez

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Endometriosis diagnosis; endometriosis therapy; endometriosis surgery; Bayesian statistics; evidence-based medicine

Online: 14 June 2023 (07:38:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1832.v1

A Review of CAD systems for Breast Mass Detection in Mammography Based on Deep Learning

Shahriar Mohammadi, Mohammad Ahmadi Livani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Breast cancer; convolution neural networks; computer-aided diagnosis systems; segmentation; classification

Online: 26 May 2023 (03:50:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0565.v1

Immunobiochemical Aspects in the Pathogenesis, Diagnosis, and Management of Novel Coronavirus (SARS-Cov-2) Infection

Venkata Bharat Kumar Pinnelli, Mangala N. Sirsikar, W. Vishnu Vandana, Shrabani Mohanty, Wilma Delphine Silvia CR, Ranjan Kumar Mohapatra, Sabitha Vadakedath, Venkataramana Kandi

Subject: Biology And Life Sciences, Virology Keywords: Coronavirus; SARS-CoV-2; COVID-19; Immunobiochemical aspects; pathogenesis; diagnosis; management

Online: 24 September 2020 (04:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0361.v1

Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment – Case of COVID-19

Mauno Vihinen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; SARS-CoV-2; pathogenicity model; diagnosis; progression prediction; poikilosis

Online: 24 March 2020 (14:43:24 CET)

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Working Paper ARTICLE

Fault Diagnosis of Diesel Engine Valve Clearance Based on Variational Mode Decomposition and Random Forest

Nanyang Zhao, Zhiwei Mao, Donghai Wei, Haipeng Zhao, Jinjie Zhang, Zhinong Jiang

Subject: Engineering, Mechanical Engineering Keywords: diesel engine; fault diagnosis; variational mode decomposition; random forest; feature extraction

Online: 25 December 2019 (11:13:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0208.v1

Artificial Intelligent-Powered Detection of Tuberculosis

Abdullahi Umar Ibrahim, Manal Salah Babiker, Yeni Wahyuni Hartati, Yeni Wahyuni Hartati

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Tuberculosis; Artificial Intelligence; Machine Learning; Deep Learning; Transfer Learning; Computer-aided Diagnosis

Online: 14 September 2022 (12:00:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0062.v1

The Prognostic Role of Diagnostic Criteria for COVID-19 Associated Pulmonary Aspergillosis: A Cross-Sectional Retrospective Study

Erika Asperges, Rebecca Pesare, Cecilia Bassoli, Matteo Calia, Sonia Lerta, Francesco Citiolo, Giuseppe Albi, Caterina Cavanna, Paolo Sacchi, Raffaele Bruno

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; pulmonary aspergillosis; case definitions; CAPA; certain/probable/possible diagnosis

Online: 2 January 2024 (09:46:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0103.v2

MERS-CoV and SARS-CoV Infections in Animals: A Systematic Review and Meta-Analysis of Prevalence Studies

D. Katterine Bonilla-Aldana, María C. Cardona-Trujillo, Alejandra García-Barco, Yeimer Holguin-Rivera, Isabella Cortes-Bonilla, Hugo A. Bedoya-Arias, Leidy Jhoana Patiño-Cadavid, Juan David Tamayo-Orozco, Alberto Paniz-Mondolfi, Lysien I. Zambrano, Kuldeep Dhama, Ranjit Sah, Ali A. Rabaan, Graciela J. Balbin-Ramon, Alfonso J. Rodriguez-Morales

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Coronavirus; SARS-CoV; MERS-CoV; serology; molecular diagnosis; reservoir; public health

Online: 19 May 2020 (04:13:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1782.v1

Refinement of the rKLi8.3 Based Serodiagnostic Elisa Allows Detection of Canine Visceral Leishmaniasis in Dogs with Low Antibody Titers

Henrique Couto Teixeira, Giulia Pereira Costa Valle, Rouzbeh Mahdavi, Priscila Santos Martins Dias, Erick Esteves De Oliveira, Cristina Aira, Daniela Heinz, Andreas Latz, Marta de Lana, Fernanda Morgado, Renato Porrozzi, Ulrich Steinhoff

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Leishmaniasis; Canine leishmaniosis; Sero-Diagnosis; Recombinant proteins; Kinesins; POC diagnostics; Asymptomatic CanL

Online: 24 January 2024 (14:47:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0096.v1

ColoSTEM Dx Kit: Innovative Alliance of Cancer Stem Cells and Glycosylation for Earlier Prediction of Colon Cancer Aggressiveness and Prognosis

Sabrina Blondy, Stéphanie Durand, Aurélie Lacroix, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Alain Chaunavel, Vincent Carre, Marie-Odile Jauberteau, Fabrice Lalloue, Muriel Mathonnet

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Aggressiveness; biomarker; cancer stem cells; diagnosis; colon cancer; glycan; immunohistochemistry; lectin; prognosis

Online: 4 November 2021 (09:23:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0100.v1

Cut-off Values of Hematologic Parameters to Predict the Number of Alpha Genes Deleted in Subjects with Deletional Alpha Thalassemia

Diego Velasco-Rodríguez, Carlos Blas, Juan-Manuel Alonso-Domínguez, Gala Vega, Carlos Soto, Aránzazu García-Raso, Pilar Llamas-Sillero

Subject: Medicine And Pharmacology, Hematology Keywords: alpha; thalassemia; deletional; cut-off; number of genes; microcytic anemia; differential diagnosis

Online: 21 September 2017 (04:47:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1123.v1

The Complexity of Skeletal Transverse Dimension: From Diagnosis, Management, and Treatment Strategies to the Application of Collaborative Cross (CC) Mouse Model

Nezar Watted, Iqbal M Lone, Kareem Midlej, Osayd Zohud, Obaida Awadi, Samir Masarwa, Ali Watted, Eva Paddenberg, Sebastian Krohn, Christian Kirschneck, Peter Proff, Fuad A. Iraqi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Skeletal Transverse Dimension; Diagnosis; management; treatment strategies; Collaborative Cross (CC) mouse model

Online: 15 January 2024 (10:58:39 CET)

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Static and functional occlusal relationships are the well-defined objectives of orthodontic therapy. To accomplish it, the jaws must be positioned in centric relation (CR)/ Central occlusion (CO) and appropriately proportioned in three space planes. Orthodontists have well-established techniques when analyzing the skeletal connection between the maxilla and mandible in both sagittal and vertical planes. Although there exist multiple analyses for the skeletal transverse dimension (STD), their inclusion in conventional orthodontic diagnosis is not widely acknowledged. Transverse tooth compensations have been visually represented in prosthodontic literature using a crosshatch arch that passes through the buccal and palatal cusps of maxillary molars, known as the Wilson curve. An inflated Wilson curve has long been seen as a prosthetic maxim, increasing the possibility of working and non-working side interferences. Research has indicated a connection between higher masticatory muscle activity and posterior occlusal contacts or interferences. When skeletal transverse issues are concealed by dental expansion, there is an elevated susceptibility to gingival recession in orthodontic patients who have a small Maxilla or constricted upper jaw. The temporomandibular joints, muscles, periodontal tissue, and airway might all suffer in a susceptible patient with a transverse insufficiency brought on by a narrow maxilla. As for orthodontists, the objective is to create skeletal connections and functional occlusion that are as near ideal as feasible. This will reduce the likelihood of occlusion-related inconsistencies exacerbating the negative consequences on the dentition, periodontium, or joints. An accurate skeletal and dental diagnostic in all three space planes is required. Our goal is to explain all approaches to enable readers to use a transverse skeletal diagnostic in their practice regardless of the technological level at their disposal. The initial step is to ascertain the kind and presence of deficiencies in the maxilla. Since fewer soft tissue alterations are caused by maxilla hypoplasia in the transverse direction, skeletal transverse dimension (STD) assessment is a more significant challenge than vertical or sagittal discrepancy assessment. Model analysis, clinical assessments, radiographic measurements, and occlusograms have all proven successful in producing accurate assessments. Most of the time, surgically assisted maxillary expansion (SARME) is reported to have higher stability than orthopedic maxillary expansion (OME). We examine and discourse on possible research opportunities using the Collaborative Cross (CC) mouse model as a substitute research model.

Preprint ARTICLE | doi:10.20944/preprints202311.1353.v1

Diagnosis of Multiple Open-Circuit Faults in Three phase Induction Machine Drive Systems Based on Bidirectional Long Short-Term Memory Algorithm

Badii Gmati, Amine Ben Rhouma, Houda Meddeb, Sejir Khojet El Khil

Subject: Engineering, Electrical And Electronic Engineering Keywords: Fault Diagnosis; Power Converters; Open-Circuit Fault; Deep Learning; AC drives

Online: 21 November 2023 (15:16:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0885.v1

Novel Diagnostic and Immunotherapeutic Approaches for Wheat Allergy

Wanqi Zheng, Christine Yee Yan Wai, Jason Ka Chun Sit, Nam Sze Cheng, Christy Wing Man Leung, Ting Fan Leung

Subject: Immunology And Allergy, Medicine And Pharmacology Keywords: Component-resolved diagnosis; desensitization; immunology; oral immunotherapy; wheat allergy

Online: 13 May 2024 (17:05:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0834.v1

Smartphone-Based Fundus Camera and Telemedicine: A Study in the Brazilian Amazon Forest

Josmar Sabage, Luis Expedito Sabage, João Vitor Mota Lanzarin, Leonardo Resende de Sousa, Isabela Ussifati Negrine, Carolina Poltronieri Chiaroni, Ana Claudia Ferreira de Almeida, Alessandra Mazzo, Ênio Luís Damaso, Luiz Fernando Manzoni Lourençone

Subject: Ophthalmology, Medicine And Pharmacology Keywords: ophthalmology; telemedicine; health disparity; minority and vulnerable populations; diagnosis

Online: 13 May 2024 (10:27:51 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0362.v1

Achilles Tendon Rupture Associated with Missed Bimalleolar Fracture: A Rare Case Report and Literature Review

TUJI MOHAMMED SANI, ABIY WORKU HAILE

Subject: Orthopedics And Sports Medicine, Medicine And Pharmacology Keywords: Achilles tendon rupture; Bimalleolar fracture; Incomplete diagnosis; Imaging studies

Online: 7 May 2024 (10:54:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0101.v1

Coupling Fault Diagnosis Based on Dynamic Vertex Interpretable Graph Neural Network

Shenglong Wang, Bo Jing, Jinxin Pan, Xiangzhen Meng, Yifeng Huang, Xiaoxuan Jiao

Subject: Mechanical Engineering, Engineering Keywords: Coupling fault diagnosis; graph neural networks; interpretability; dynamic vertex

Online: 2 May 2024 (12:14:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1692.v1

HRM Accuracy and Limitations as a Species Typing Tool for Leishmania Parasites

Camila Patricio Braga Filgueira, Daniela Pitta-Pereira, Lilian Motta Cantanhêde, Gabriel Eduardo Melim Ferreira, Sayonara Dos Reis, Elisa Cupolillo, Otacilio C. Moreira, Constança Britto, Mariana Côrtes Boité

Subject: Biology And Life Sciences, Parasitology Keywords: HRM; Leishmania; Americas; leishmaniasis; qPCR; parasite typing; HSP70; diagnosis.

Online: 24 August 2023 (09:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0739.v1

An Improved Fault Diagnosis Approach for Pumps Based on Neural Networks with Improved Adaptive Activation Function

Fangfang Zhang, Yebin Li, Dongri Shan, Yuanhong Liu, Fengying Ma

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Deep learning; fault diagnosis; adaptive activation function; pumping unit

Online: 9 August 2023 (07:22:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1972.v1

Designing Effective Instructional Feedback Using Diagnostic and Visualization System: Evidence from a High School Biology Class

Lin Ma, Xuedi Zhang, Zhifeng Wang, Heng Luo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: instructional feedback; feedback design; cognitive diagnosis; visualization; high school

Online: 28 June 2023 (09:47:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1701.v1

Evaluating Sarcopenia Using Bioelectrical Impedance Vector Analysis and Phase Angle

Saizhao Tang, Fang Lin Jiang, Seon-Ho Eom, Jae-Young Lee, Ji Heon Chae, Chul-Hyun Kim

Subject: Public Health And Healthcare, Primary Health Care Keywords: bioelectrical impedance vector analysis; phase angle; aging; diagnosis; noninvasive

Online: 25 June 2023 (03:09:52 CEST)

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Sarcopenia becomes more common with age, being most prevalent among elderly individuals. According to the EWGSOP, muscle mass is one of the criteria for the evaluation of sarcopenia. The main methods for evaluating muscle mass are CT, MRI, and DXA, but these methods are difficult to apply in the field due to equipment costs, radioactivity, and lack of portability. BIVA and PhA are alternative approaches for assessing somatic cell mass and volume and do not require predictive equations. These variables are clinically relevant parameters that indicate cell health, especially cell membrane integrity and cell function. This study in sarcopenic and nonsarcopenic elderly volunteers aimed to determine the BIVA distribution pattern among individual sarcopenia patients; to evaluate the relationship between PhA and muscle strength, muscle quality, and physical function; and to find any correlates of PhA. The sample comprised 134 free-living elderly individuals of both sexes aged 69–91 years. Anthropometric parameters, grip strength, DXA findings, BIA results, and physical performance (the 6-meter walk test) were measured. Impedance vector distributions were evaluated in sarcopenia patients and healthy elderly individuals using BIVA. According to the AWGS criteria, sarcopenia was diagnosed according to DXA findings, grip strength and physical performance test results. Group differences were evaluated using the t test, Mann‒Whitney U test, and Hotelling's T2 test. Correlation analysis was performed to identify variables significantly associated with PhA. Linear regression analysis was performed to determine whether PhA was associated with muscle strength, muscle quality and physical function. BIVA detected a significant difference between the sarcopenia and non-sarcopenia groups (both sexes) due to higher R/H values and lower phase angles in a few individuals, whereas Xc/Ht values did not differ between the two groups. The sarcopenia group had a significantly lower PhA than the non-sarcopenia group among both males (p<0.01) and females (p<0.05). PhA was significantly correlated with age, ASM, HGS, and muscle quality in both sexes and significantly correlated with ASM/Ht2 and physical performance in males. PhA was a significant indicator of muscle strength in both males (β = 2.6; p<0.01) and females (β = 3.4; p<0.01), a significant indicator of muscle quality in both males (β = 0.07; p<0.05) and females (β = 0.17; p<0.01), and a significant indicator of physical performance in males (β = 0.3; p<0.01). BIVA can detect changes in muscle mass in individuals with sarcopenia and is a practical method for the assessment of sarcopenia in the field. PhA is a good indicator of muscle strength, muscle quality and physical performance (in males). These methods can help diagnose sarcopenia in elderly individuals with reduced mobility.

Preprint REVIEW | doi:10.20944/preprints202305.0298.v1

Expert Systems for Farmed Fish Disease Diagnosis: An Overview and a Proposal

Ioannis Hatzilygeroudis, Konstantinos Dimitropoulos, Konstantinos Kovas, John A. Theodorou

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: expert systems; aquaculture; fish health management; fish disease diagnosis

Online: 5 May 2023 (04:36:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0109.v1

Clinical Diagnosis for Chikungunya Infection: An Essential Aid in a Primary Care Setting Where Serological Confirmation Is Not Available

Juan C. Rueda, Ingris Peláez-Ballestas, Jose-Ignacio Angarita, Ana M. Santos, Carlos Pinzon, Eugenia-Lucia Saldarriaga, Jorge M. Rueda, Elias Forero, Diego L. Saaibi, Paula X. Pavía, Marta Juliana Mantilla, Gustavo Rodríguez-Salas, Juan Camilo Santacruz, Igor Rueda, Mario H. Cardiel, John Londono

Subject: Biology And Life Sciences, Virology Keywords: Chikungunya virus; diagnosis; arbovirus infections; clinical decision making; Colombia

Online: 6 March 2023 (15:17:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0224.v1

Recognizing and Distinguising the Phenomenon Referred to as Meningioma

Bruce M. Rothschild

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: meningioma; hemangioma; cranial pathology; porotic hyperostosis; differential diagnosis; osteosarcoma

Online: 14 July 2022 (12:29:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0213.v1

The Big Picture

Beth Alderman

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Toxicity; Diagnosis; Personal care; Patient encounter; Patient-based medicine

Online: 16 May 2022 (14:06:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0309.v1

Desertification in Spain: A Sound Diagnosis Unfollowed by Solutions

Jaime Martínez-Valderrama, Gabriel del Barrio, Maria E. Sanjuán, Emilio Guirado, Fernando T. Maestre

Subject: Environmental And Earth Sciences, Environmental Science Keywords: combat desertification; diagnosis; socioeconomic factors; convergence of evidence; agriculture

Online: 20 January 2022 (14:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0387.v1

Early Malaria Diagnosis and Treatment Seeking Behavior Among Clients Attending Outpatient Department Sekou-Toure Regional Referral Hospital in Mwanza, Tanzania; A Cross-Sectional Study

Samson Mvandal, Godfrida Marandu

Subject: Social Sciences, Cognitive Science Keywords: Early diagnosis; behavior; illness; malaria; Mwanza; treatment-seeking; Tanzania

Online: 23 December 2021 (11:50:15 CET)

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Early diagnosis of malaria and treatment seeking behavior play key role in controlling and preventing further complication related to malaria disease. Aim of this study was to determine the responses on early malaria diagnosis and treatment seeking behavior among outpatient clients attending at Sekou toure regional referral hospital in Mwanza, Tanzania. Methods: A cross-sectional study was conducted among outpatient client at Sekou-Touré regional referral hospital, convenient simple random sampling used and self-administered questionnaire were used to collect data and data was entered into Microsoft excel and then exported to SPSS version 25.0 for further analysis and presented on the percentages and table. The analysis of strength of relationships between categorical variables was conducted using the Chi-square test. A p-value of ≤ 0.05 was considered to be statistically significant. Results: A total of 192 respondents completed the study with a response rate of 97.6%. The study revealed that Most of the respondents about 90.6% stated they would seek treatment from health facility when symptoms appear. However, only 6.3% seek treatment within 24 hours of onset of illness (p= 0.017). Half of respondents (50.5%) experienced malaria symptoms in the past six months and only 30% seek for treatment at health facility. Preference of health facility, (51%) respondents were going direct to pharmacy to buy medicine for self-treatment. Overall, cost of service, time consumed and distance of health facility especially health center shows significant with such delay. Conclusion: A low proportion of malaria-suspected patients sought treatment within 24 h of fever onset compared to the national target. Distance from the health facility, cost of service and time consumed were found to be predictors of early treatment-seeking behavior for malaria. Strengthening strategies tailored to increasing awareness for communities about malaria, importance of going hospital and early treatment-seeking behavior is essential.

Preprint ARTICLE | doi:10.20944/preprints202109.0390.v1

COVID-19 Diagnosis by 5-second Facial Video Processing Using Vibraimage and Artificial Intelligence

Viktor Minkin, Valery Akimov

Subject: Biology And Life Sciences, Biophysics Keywords: COVID-19; vibraimage; behavioral parameters; diagnosis accuracy; ANN; AI

Online: 22 September 2021 (16:28:12 CEST)

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The Covid-19 pandemic spreads in waves for a year and a half, despite significant worldwide efforts, the development of biochemical diagnostic methods and population vaccination. One of the reasons for the infection spread is the impossibility of early disease detection through biochemical diagnostics, since biochemical processes slowly develop in a body. At the same time, well known that behavioral characteristics of a person, measured based on reflex movements, are capable for inertialess assessment of psychophysiological parameters. Vibraimage technology is the method of head micromovements video processing by inter-frame difference accumulation and converting spatial and temporal characteristics of the inter-frame difference into behavioral and psychophysiological parameters. Here we shown that behavioral parameters measured by vibraimage changed during COVID-19 infection. The identification of changes signs in behavioral parameters detected by AI trained on patients and controls. The best diagnostic accuracy (higher 94%) obtained using instantaneous values of behavioral parameters measured with the following vibraimage settings: 10Hz frequency of basic measurements; 25 inter-frame difference accumulations and averaging the diagnostic results over period of at least 5 seconds. COVID-19 diagnoses by behavioral parameters showed earlier (5-7 days) detection of the disease compared to symptoms and positive results of biochemical RT-PCR testing. Proposed method for COVID-19 diagnosis indicates infected persons within 5 seconds video processing using standard television cameras (web, IP) and computers, allows mass testing/selftesting and will stop the pandemic spread. We assume that head micromovements analysis for diagnosis of various diseases is possible not only with the help of vibraimage technology. Further research of human head micromovement analysis will help stop the COVID-19 pandemic and will contribute to the development of new contactless and environmentally friendly methods for early diagnosis of diseases.

Preprint REVIEW | doi:10.20944/preprints202008.0516.v1

A Systematic Review on Coronavirus Disease 2019 (COVID-19)

Hira Karim, Muhammad Shahzeb Khan

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Coronavirus, sequence homology, transmission, virology, diagnosis, virus control, vaccination.

Online: 24 August 2020 (09:31:38 CEST)

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Emerging and reemerging pathogens is a global challenge for public health. Recently, a novel coronavirus disease emerged in Wuhan, Hubei province of China, in December 2019. It is named COVID-19 by World Health Organization (WHO). It is known to be caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that affects the lower respiratory tract and manifests as pneumonia in humans. Coronaviruses (CoVs) are structurally more complicated as compared to other RNA viruses. This viral epidemic has led to the deaths of many, including the elderly or those with chronic disease or compromised immunity. Viruses cause infection and diseases in humans of varying degrees, upper respiratory tract infections (URTIs) cause common cold while lower respiratory tract infections induce pneumonia, bronchitis, and even severe acute respiratory syndrome (SARS). The costs of COVID-19 are not limited. It equally affects all the medical, sociological, psychological, and economic aspects globally. This is regarded as the third deadly outbreak in the last two decades after Severe Acute Respiratory Syndrome SARS (2002–2003) and Middle East Respiratory Syndrome MERS (2012). Based on the sequence homology of SARS-CoV-2, different animal sources including bats, snakes, and pangolins have been reported as potential carriers of this viral strain. Real-time RT-PCR represents the primary method for the diagnosis of new emerging viral strain SARS-CoV-2. The transmission dynamics suggest that SARS-CoV-2 is transmitted from person-to-person through direct contact or coughing, sneezing, and by respiratory droplets. Several anti-viral treatments including lopinavir/ritonavir, remdesivir, chloroquine phosphate, and abidor are also suggested with different recommendations and prescriptions. Protective and preventive strategies as suggested by various health organization i.e. WHO and US Center for Disease Control and Prevention (CDC) must be adopted by everyone. This review covers the important aspects of novel COVID-19 including characteristics, virology, symptoms, diagnostics, clinical aspects, transmission dynamics, and protective measures of COVID-19.

Preprint ARTICLE | doi:10.20944/preprints201903.0250.v1

A Periodic Potential Underdamped Stochastic Resonance Method and Its Application for Gear Fault Diagnosis

Zhixing Li, Xiandong Liu, Tian He, Yingchun Shan

Subject: Engineering, Mechanical Engineering Keywords: fault diagnosis, stochastic resonance, periodic potential, underdamped, weak signal

Online: 27 March 2019 (08:49:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0213.v1

Coronavirus ORF1ab Polyprotein Associated Nsp16 Protein is a RlmE Methyltransferase and May Methylate 21S Mitochondrial rRNA of Host Cells Inhibiting Protein Synthesis

Asit Kumar Chakraborty

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: covid-19; rlmE MTase; new drug target; corona diagnosis; corona pandemic

Online: 13 April 2020 (12:33:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0147.v1

Whole Genome Alignment Based Development of Molecular Marker for Detecting Leptosphaeria maculans and Leptosphaeria biglobosa, the Causal Agent of Blackleg Disease in Brassicas

Mostari Jahan Ferdous, Mohammad Rashed Hossain, Denison Michael Immanuel Jesse, Jong-In Park, Hee-Jeong Jung, Hoy-Taek Kim, Ill-Sup Nou

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: blackleg; brassica; diagnosis; effector; genome alignment; leptosphaeria biglobosa; leptosphaeria maculans; marker; PCR

Online: 13 October 2019 (16:08:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0276.v1

The Role of ChatGPT in the Advancement of Diagnosis, Management, and Prognosis of Cardiovascular and Cerebrovascular Disease

David-Dimitris Chlorogiannis, Anastasios Apostolos, Anargyros Chlorogiannis, Leonidas Palaiodimos, George Giannakoulas, Sumant Pargaonkar, Sofia Xesfingi, Damianos G. Kokkinidis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiovascular disease; cerebrovascular disease; chatGPT; language based models; diagnosis; treatment; stroke; myocardial infarction

Online: 5 October 2023 (12:06:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0935.v1

Fault-Tolerant Model Predictive Control Applied of a Sewer Network

Antonio Cembellín, María J. Fuente, Pastora Vega, Mario Francisco

Subject: Control And Systems Engineering, Engineering Keywords: Fault Detection and Diagnosis; Fault-Tolerant Control; Model Predictive Control; sewer systems

Online: 14 May 2024 (10:42:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1505.v1

Diagnostic Accuracy of Multiplex PCR in Early Onset Neonatal Sepsis

Anja Stein, Daniel Soukup, Peter-Michael Rath, Ursula Felderhoff-Müser

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: neonatal sepsis; early onset sepsis; multiplex PCR; infection; neonate; diagnosis; pathogen detection

Online: 24 October 2023 (08:11:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0200.v1

Machine Learning in Apache Spark Environment for Diagnosis of Diabetes

Farshid Bagheri Saravi, Shadi Moghanian, Giti Javidi, Ehsan O Sheybani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Diabetes; Diagnosis; Machine Learning; Wireless Body Area Networks; Apache Spark; Feature Selection

Online: 10 November 2021 (09:00:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0571.v1

An Improved of Fault Diagnosis Using 1D-Convolutional Neural Network Model

Chih-Cheng Chen, Zhen Liu, Guangsong Yang, Chia-Chun Wu, Qiubo Ye

Subject: Engineering, Electrical And Electronic Engineering Keywords: 1D-CNN; fault diagnosis; rolling bearing; vibration signal; single load; different load

Online: 23 November 2020 (09:22:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0106.v1

Seasonality of discrepancies between admission and discharge diagnosis for Medicare patients

Aashara Shrestha, Dimitrios Zikos, Leonidas Fegaras

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Health Informatics; Clinical Decision Making; Seasonal Variations; Admission Diagnosis; Health Outcomes; Visualization

Online: 5 November 2018 (10:57:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0020.v1

Clinical Utility of Expanded Carrier Screening: Results-Guided Actionability and Outcomes

Katherine Johansen Taber, Kyle A. Beauchamp, Gabriel Lazarin, Dale Muzzey, Aishwarya Arjunan, James D. Goldberg

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: expanded carrier screening; prenatal diagnosis; pregnancy management; clinical utility; at-risk couple

Online: 1 August 2018 (12:07:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0418.v1

Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with ⁴⁴Sc and ⁴⁷Sc for Theranostic Application

Perihan Unak, Volkan Yasakçı, Elif Tutun, K. Buşra Karatay, Rafał Walczak, Kamil Wawrowicz, Kinga Żelechowska-Matysiak, Agnieszka Majkowska-Pilip, Aleksander Bilewicz

Subject: Chemistry And Materials Science, Nanotechnology Keywords: SPION; multimodal nanoparticles; PET diagnosis; MRI; 44/47Sc; PSMA-617; prostate cancer

Online: 24 February 2023 (04:36:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0069.v1

Sampling and Analysis of Low Molecular Weight Volatile Metabolites in Cellular Headspace and Mouse Breath

Theo Issitt, Sean T Sweeney, William J. Brackenbury, Kelly Redeker

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Volatile organic compound; VOC; headspace; breath; breath biomarker; volatile metabolite; breath diagnosis

Online: 6 May 2022 (09:27:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0002.v1

Candida Variety in the Oral Cavity of Mexican Subjects with Type 2 Diabetes Mellitus and TLR2 Gene Expression

NADIA MABEL PEREZ VIELMA, MODESTO GÓMEZ LÓPEZ, MARÍA DE LOS ANGELES MARTÍNEZ GODÍNEZ, ANA LAURA LUNA TORRES, AARÓN DOMÍNGUEZ LÓPEZ, ANGEL MILIAR GARCÍA

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Candida, type 2 diabetes mellitus, PAP stain, oral cavity, molecular diagnosis, TLR2

Online: 1 February 2024 (09:32:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0392.v1

Open-Circuit Fault Diagnosis of Wind Power Converter Using Variational Mode Decomposition, Trend Feature Analysis and Deep Belief Network

Jingxuan Zhang, Hexu Sun, Zexian Sun, Yan Dong, Weichao Dong

Subject: Engineering, Electrical And Electronic Engineering Keywords: power converter; fault diagnosis; intelligent algorithm; variational mode decomposition; deep belief network

Online: 26 February 2020 (11:25:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0320.v1

Performance Characteristics of Real-time PCRs for African Swine Fever Virus Genome Detection – comparison of Twelve Kits to an OIE Recommended Method

Jutta Pikalo, Tessa Carrau, Paul Deutschmann, Melina Fischer, Kore Schlottau, Martin Beer, Sandra Blome

Subject: Biology And Life Sciences, Virology Keywords: African swine fever virus; laboratory diagnosis; commercial real-time PCR; performance; sensitivity; specificity

Online: 21 December 2021 (09:24:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1378.v1

Impact of Voxel Normalization on Machine Learning-Based Method: A Study on Pulmonary Nodule Malignancy Diagnosis Using Low-Dose Computed Tomography (LDCT)

Chia-Chi Hsiao, Chen-Hao Peng, Fu-Zong Wu, Da-Chuan Cheng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: lung cancer; isotropic voxel reconstruction; lung nodule classification; radiomics; computer-aided diagnosis

Online: 23 October 2023 (05:34:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0285.v1

Clinical, Laboratory, and Radiological Features Indicative of Novel Coronavirus Disease (COVID-19) in Emergency Departments – A Multicentre Case-Control Study in Hong Kong

Rex Pui Kin Lam, Kevin Kei Ching Hung, Eric Ho Yin Lau, Chun Tat Lui, Kin Ling Chan, Chin San Leung, Ion Wa Wong, Kin Wa Wong, Colin A. Graham, Patrick Chiu Yat Woo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; SARS-CoV-2; emergency department; early diagnosis; case-control studies

Online: 17 May 2020 (08:27:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1140.v1

Research on Construction and Application of Aircraft Fault Knowledge Graphs

Xilang Tang, Guo Chi, Lijie Cui, Andrew W.H. Ip, Kai Leung Yung, Xiaoyue Xie

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Aircraft fault diagnosis; knowledge graph; deep learning; fault knowledge extraction; question-answering system

Online: 28 April 2023 (08:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0758.v1

Correlation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment

Mr Tufael, Auditi kar, Vijay Jagdish Upadhye, Atiqur Rahman Sunny, Antonio Raposo, Md. Saidul Islam, Md Haroon Or Rashid, Mohammad Anowar Hussen, Heesup Han, Henrique Douglas Melo Coutinho, Md. Sefaul Ullah, Md. Mizanur Rahman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hepatocellular carcinoma; Tumor markers; Chemiluminescence assay; Occupational exposure; Early diagnosis

Online: 10 January 2024 (05:44:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1152.v1

A Technical Comparative Heart Disease Prediction Framework Using Boosting Ensemble Techniques

Najmu Nissa, Sanjay Jamwal, Mehdi Neshat

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Heart Disease; Diagnosis, Machine Learning; Boosting; Ensemble learning; Comparative framework

Online: 18 December 2023 (02:45:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1692.v1

Cardiovascular Disease Preliminary Diagnosis Application Using SQL Queries: Filling Diagnostic Gaps in Resource-Constrained Environments

Rafał Doniec, Eva Odima Berepiki, Natalia Piaseczna, Szymon Sieciński, Artur Piet, Muhammad Tausif Irshad, Ewaryst Tkacz, Tomasz Cedro, Abid Ali Fareedi, Stéphane Gagnon, Marcin Grzegorzek, Wojciech Glinkowski

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: n/a; Ontology; Database; Cardiovascular Diseases; Diagnosis; Decision Support Systems

Online: 26 October 2023 (10:08:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0446.v1

Autoimmune Encephalitis – a variable pathology

Monica Neațu, Ana Jugurt, Anca Covaliu, Eugenia Irene Davidescu, Bogdan Ovidiu Popescu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: autoimmune encephalitis; encephalitis symptoms; diagnosis autoimmune encephalitis; treatment autoimmune encephalitis

Online: 7 July 2023 (10:13:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1909.v1

Diabetic Ketoacidosis in Children and Adolescents; Diagnostic and Therapeutic Pitfalls

Eirini Kostopoulou, Xenophon Sinopidis, Sotirios Fouzas, Despoina Gkentzi, Theodore Dassios, Stylianos Roupakias, Gabriel Dimitriou

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetic ketoacidosis; type 1 diabetes mellitus; pitfalls; children; diagnosis; management

Online: 27 June 2023 (12:51:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1623.v1

Stator ITSC Fault Diagnosis for EMU Induction Traction Motor based on Goertzel Algorithm and Random Forest

Jie Ma, Yingxue Li, Liying Wang, Jisheng Hu, Hua Li, Jiyou Fei, Lin Li, Geng Zhao

Subject: Engineering, Electrical And Electronic Engineering Keywords: Goertzel algorithm; ITSC fault; traction motor; random forest; fault diagnosis

Online: 23 May 2023 (08:31:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0518.v2

Nucleic Acid Liquid Biopsies in Alzheimer’s Disease: Current State, Challenges, and Opportunities

Tabea M. Soelter, Jordan H. Whitlock, Avery S. Williams, Andrew A. Hardigan, Brittany N. Lasseigne

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: liquid biopsy; circulating biomarkers; Alzheimer’s disease; neurodegeneration; cell-free; diagnosis

Online: 8 March 2022 (09:56:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0604.v2

RT-qPCR Diagnostics: The “Drosten” Sars-Cov-2 Assay Paradigm

Stephen Bustin, Sara Kirvell, Jim F Huggett, Tania Nolan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; reverse transcription; qPCR; SARS-CoV-2; molecular diagnosis

Online: 3 August 2021 (15:34:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0285.v1

Quantitative Fluorescent Polymerase Chain Reaction for Prenatal Diagnosis and Its Application in Vietnam: A Literature Review

Thuan Phan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: QF-PCR; cytogenetics; prenatal diagnosis; aneuploidy; chromosome abnormalities; screening test

Online: 10 June 2021 (09:17:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0750.v1

Pitfalls and Caveats in Applying Immunostaining to Histopathological Diagnosis

Yutaka Tsutsumi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Epitope retrieval; Fixation; Histopathological diagnosis; Immunostaining; Sensitivity; Specificity; Trouble-shooting

Online: 28 April 2021 (14:17:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0569.v1

Quantitative Imaging and Radiomics in Multiple Myeloma: opportunity or hype?

Alberto Stefano Tagliafico, Alida Dominietto, Liliana Belgioia, Cristina Campi, Daniela Schenone, Michele Piana

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: multiple myeloma; computed tomography; artificial intelligence; radiomics; prognosis; imaging; diagnosis

Online: 23 November 2020 (09:17:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0040.v1

Coronavirus (Covid-19) Pandemic: Outbreak, Current Scenario, and Impact on Human Physiology in Pakistan

Komal Jabeen, Muhammad Basit Husnain Haider, Zeshan Haider, Sultan Ali, Ali Hassan, Adnan Khan Niazi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Coronaviruses; COVID-19; Pakistan; current situation; human physiology; diagnosis; treatment

Online: 2 September 2020 (09:59:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0493.v1

Diabetic Retinopathy Diagnostics from Retinal Images based on Deep Convolutional Networks

G. Arun Sampaul Thomas, Y. Harold Robinson, E. Golden Julie, Vimal Shanmuganathan, Yunyoung Nam, Seungmin Rho

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Convolutional Neural Networks; Dental Diagnosis; Image Recognition; Diabetic Retinopathy detection

Online: 31 May 2020 (18:55:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0349.v1

A Robust Deep Learning-Based Fault Diagnosis Method for Rotating Machinery

Greg Smith, John Lundberg, Masayoshi Shibatani

Subject: Engineering, Mechanical Engineering Keywords: fault diagnosis; deep learning; domain adapta-tion; gearbox; current signal

Online: 22 May 2020 (05:37:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0261.v1

Feature Selection Based on Robust LLE Vote and Its Application to Bearing Fault Diagnosis

Haishuang Yin, Zebiao Hu, Yuanhong Liu

Subject: Engineering, Control And Systems Engineering Keywords: feature selection; locally linear embedding; regularization technology; bearing fault diagnosis

Online: 22 November 2019 (10:05:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0011.v1

Critical Nutrient Concentrations and DRIS Norms for Pinus patula

Agustina Sánchez-Parada, Miguel Ángel López-López, Armando Gómez-Guerrero, Marlín Pérez-Suárez

Subject: Biology And Life Sciences, Forestry Keywords: plant nutrition; chemical fertilization; nutrient diagnosis; forest plantation; foliar nutrients

Online: 2 January 2018 (10:25:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0879.v1

Neurodegeneration in Cognitive Impairment and Mood Dis-orders for Experimental, Clinical and Translational Neuropsy-chiatry

Simone Battaglia, Alessio Avenanti, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’ s disease;
Parkinson’ s disease;
aging decline;
mild cognitive impairment;
multiple sclerosis;
stroke;
psychiatric disorders;
depressive disorder;
bipolar disorder;
post-traumatic stress disorder;
anxiety disorder;
schizophrenia;
somatic symptom disorder;
autism spectrum disorder;
hyperactive attention deficit disorder;
learning disabilities;
acquired brain damage;
altered cognitive processes;
brain functional impairment;
neurocognitive disorders;
cognitive, behavioral, and functional disorders;
acquired trauma;
brain plasticity and connectivity;
non-invasive brain stimulation;
diagnosis and treatment;
functional evidence of altered cognition and connectivity

Online: 16 February 2024 (05:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0466.v1

Pre-analytical Considerations for Clinical Assays of Circulating Human miRNA-451a for Diagnostic Purposes.

M. Rohan Fernando, Dinesh S Chandel, Wesley Tom, Chao Jiang, Gary Krzyzanowski, Nirmalee Fernando

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Preanalytical factors; Blood processing; Circulating miRNA-451; Blood storage; Hemolysis; clinical assays; diagnosis

Online: 7 December 2023 (08:18:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0487.v1

Cell Free DNA Extracted From Csf for Molecular Diagnosis of Pediatric Embryonal Brain Tumors

Mathieu Chicard, Yasmine Iddir, Julien Masliah Planchon, Valérie Combaret, Valéry Attignon, Alexandra Saint-Charles, Didier Frappaz, Cécile Conter, Kevin Beccaria, Pascale Varlet, Birgit Geoerger, Sylvain Baulande, Gaelle Pierron, Yassine Bouchoucha, François Doz, Olivier Delattre, Joshua Waterfall, Franck Bourdeaut, Gudrun Schleiermacher

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pediatric embryonal brain tumors, liquid biopsy, cell-free DNA, molecular diagnosis, nucleosome footprinting

Online: 7 June 2023 (05:48:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0358.v1

3-Dimension Epithelial Segmentation in Optical Coherence Tomography of the Oral Cavity Using Deep Learning

Chloe Hill, Jeanie Malone, Kelly Liu, Samson Pak-Yan Ng, Calum MacAulay, Catherine Poh, Pierre Lane

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: optical coherence tomography; oral cancer; deep learning; segmentation; cancer detection and diagnosis system

Online: 7 May 2024 (08:17:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0001.v2

The Identification, Management, and Control of Scabies in Australian Aboriginal and Torres Strait Islander Communities

Timothy Mettam

Subject: Medicine And Pharmacology, Dermatology Keywords: Aboriginal; Australia; control; diagnosis; identification; prevention; scabies; sarcoptes scabiei; Torres Strait Islander; treatment

Online: 8 January 2018 (16:00:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0308.v1

Plasma Spectroscopic Study of Dergaon Meteorite, India

Abhishek K. Rai, Jayanta K. Pati, Christian G. Parigger, Sonali Dubey, Awadhesh K. Rai, B. Bhagabaty, A. C. Mazumdar, K. Duorah

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Dergaon Meteorite; calibration-free laser-induced breakdown spectroscopy; atomic spectroscopy; molecular spectroscopy; planetary diagnosis

Online: 26 January 2020 (04:39:18 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202309.0305.v3

Mature Triphyllic Cystic Teratoma of the Posterior Mediastinum in a Fetus: A Case Report and Literature Review

Cecilia Salzillo, Andrea Quaranta, Giovanni De Biasi, Gerardo Cazzato, Gabriella Serio, Antonella Vimercati, Pierpaolo Nicolì, Leonardo Resta, Andrea Marzullo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mature triphyllic cystic teratoma; posterior mediastinum; fetal teratoma; germ cell tumor; prenatal diagnosis

Online: 18 September 2023 (07:14:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0319.v1

Profiles of Motor-cognitive Interference in Parkinson's Disease. The Trail-Walking-Test to Discriminate between Motor Phenotypes

Thomas J. Klotzbier, Nadja Schott, Quincy J. Almeida

Subject: Social Sciences, Cognitive Science Keywords: dual-task; Trail-Walking Test; gait disorder; diagnosis; motor-cognitive interference; Parkinson's disease

Online: 21 July 2022 (08:57:20 CEST)

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Background and Aims. Most research on Parkinson's disease (PD) focuses on describing symp-toms and movement characteristics. Studies rarely focus on the early detection of PD and the search for suitable markers of a prodromal stage. Early detection is important, so treatments that may potentially change the course of the disease can be attempted early on. While gait disturb-ances are less pronounced in the early stages of the disease, the prevalence, and severity increase with disease progression. Therefore, postural instability and gait difficulties could be identified as sensitive biomarkers. The aim was to evaluate the discriminatory power of the Trail-Walking Test (Schott, 2015) as a potential diagnostic instrument to improve the predictive power of the clinical evaluation concerning the severity of the disease and record the different aspects of walking. Methods. 20 older healthy (M = 72.4 years, SD = 5.53) adults and 46 older adults with PD and the motor phenotypes postural instability/gait difficulty (PIGD; M = 69.7 years, SD = 8.68) and tremor dominant (TD; M = 68.2 years, SD = 8.94) participated in the study. The participants performed a motor-cognitive dual task (DT) of increasing cognitive difficulty in which they had to walk a given path (condition 1), walk to numbers in ascending order (condition 2), and walk to numbers and letters alternately and in ascending order (condition 3). Results. With an increase in the cognitive load, the time to complete the tasks (seconds) become longer in all groups, F(1.23, 73.5) = 121, p < .001, ɳ2p = .670. PD-PIGD shows the longest times in all conditions of the TWT, F(2, 60) = 8.15, p < .001, ɳ2p = .214. Mutual interferences in the cognitive and motor domain can be observed. How-ever, clear group-specific patterns cannot be identified. A differentiation between the motor phenotypes of PD is especially feasible with the purely motor condition (TWT-M; AUC = . 685, p = 0.44). Conclusions. PD patients with PIGD must be identified by valid, well-evaluated clinical tests that allow a precise assessment of the disease's individual fall risk, the severity of the dis-ease, and the prognosis of progression. The TWT covers various aspects of mobility, examines the relationship between cognitive functions and walking, and enables differentiation of the motor phenotypes of PD.

Preprint ARTICLE | doi:10.20944/preprints202312.1960.v1

The Diagnosis, Treatment, and Prevention of Glaucoma – An Update

Karen Allison, Kevin Andrew Morabito, Margaret M. DeAngelis, Deepkumar Patel

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; epidemiology of glaucoma; open angle glaucoma; blindness; disparities in glaucoma treatment and diagnosis

Online: 28 December 2023 (02:26:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0997.v1

Milk Microbiota of Clinical Mastitic Cows: An Etiological Approach

Simone Baldini Lucheis, Anelise Salina, Samea Fernandes Joaquim, Simony Trevisan Guerra, Felipe Freitas Guimarães, Marcio Garcia Ribeiro, Vera Lúcia Mores Rall, Rodrigo Tavanelli Hernandes, Domingos da Silva Leite, Vera Cláudia Lorenzetti Magalhães Curci, Helio Langoni

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: bovine mastitis; milk pathogens; environmental agents; microbiological diagnosis; clinical severity scores; days in milk

Online: 26 April 2023 (14:22:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0313.v1

The Complex World of Emaraviruses – Challenges, Insights and Prospects

Marius Rehanek, David G. Karlin, Martina Bandte, Rim Al Kubrusli, Shaheen Nourinejhad Zarghani, Thierry Candresse, Carmen Büttner, Susanne Von Bargen

Subject: Biology And Life Sciences, Virology Keywords: diagnosis; distribution; emaraviruses; forest trees; Fimoviridae; genome organization; phylogenetic relations; protein domains; symptomatology; transmission

Online: 20 October 2022 (14:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0198.v1

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance.

Robert McCrossin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: autistic spectrum disorder; anorexia nervosa; female; prevalence; Bayes’ Theorem; diagnosis; management; generalized joint hypermobility.

Online: 10 November 2022 (11:02:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0139.v1

Potential Super Spreading’s of SARS-2 Pandemic. A Short Review

Anthony Kyriakopoulos

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS epidemiology; super spread events; efficient diagnosis to contain magnitude of SARS-2 outbreaks

Online: 9 April 2020 (07:48:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0484.v1

Validation of the American English Version of The Acute Cystitis Symptom Score

Jakhongir F. Alidjanov, Kurt G. Naber, Adrian Pilatz, Florian M. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; ACSS; cystitis; urinary tract infection; female patients; diagnosis; patient-reported outcome

Online: 18 November 2020 (16:35:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0393.v1

Role of Artificial Intelligence in Atrial Fibrillation Management: A Comprehensive Review

Behzad Fahimi, Somayeh Beikmohammadi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Atrial Fibrillation (AF); Artificial Intelligence (AI); machine learning; AF Management; diagnosis and treatment prediction

Online: 7 November 2023 (03:40:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0216.v1

Development of a Field-deployable RT-qPCR Workflow for COVID-19 Detection

Raphael Nyaruaba, Bo Zhang, Caroline Muema, Elishiba Muturi, Greater Oyejobi, Jin Xiong, Bei Li, Zhengli Shi, Caroline Mwaliko, Junping Yu, Xiaohong Li, Hongping Wei

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; SARS-CoV-2; field work; community; diagnosis; rapid detection; inactivation; RT-qPCR

Online: 14 April 2020 (08:41:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0323.v1

Improving Prenatal Diagnosis Precision for Congenital Clubfoot by Using Three-Dimensional Ultrasonography

Yoo-min Kim, Ji Su Seong, Ji Hoi Kim, Na Mi Lee, In Ho Choi, Yejin Cho, Gina Nam, Gwang Jun Kim

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: clubfoot; congenital abnormalities; three-dimensional ultrasound; foot malpositions; prenatal diagnosis; ultrasound

Online: 6 December 2023 (07:57:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1473.v1

Remote Diagnosis on Upper Respiratory Tract Infections Based on Neural Network with Few Symptom Words – a Feasibility Study

Chung-Hung Tsai, Kuan-Hung Liu, Da-Chuan Cheng

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: natural language; remote diagnosis; GPT-2 model; deep learning; symptom words

Online: 24 October 2023 (08:34:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1184.v1

Topological Approach with Decision Making Based on Nano Beta Closure, Nano Beta Interior and its Application with Fractals in Medical Fields

M. A. El Safty, Mohamed El Sayed, Hadba F Al-Qahtani, Elhadi E. Elamir, A Al Qarni

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: Medical diagnosis; rough sets; Nano Beta-topological space; Decision-making; Accuracy

Online: 19 October 2023 (03:52:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0288.v1

Identifying the Common Cell-Free DNA Biomarkers across Seven Major Cancer Types

Mingyu Luo, Yining Liu, Min Zhao

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Early cancer diagnosis; cell free DNA; biomarker; integrative biology; pan cancer

Online: 5 June 2023 (09:20:14 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202104.0693.v1

COVID-19 Clinical Practice Guidelines Hadhramout Initiative Against Corona Group (HIAC Group)

Abdulla A. Baradwan, Khalid H. Ba-Msahell, Iman A. Ba-Saddik, Ibrahim Albakri, Hassan O. Batis, Ahmed Babiqai, Ahmed Al habshi, Shaker Bajaber, Ahmed M. Badheeb

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; SARS-CoV-2; HIAC Recommendation; Diagnosis; Treatment; Discharge Management

Online: 26 April 2021 (20:42:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0211.v1

Mass Antibody Detection: Can It be An Avenger for Infectivity War against COVID-19

Sarfaraz Ahmad Ejazi, Sneha Ghosh, Nahid Ali

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; diagnosis; ELISA; RDT; point-of-care test; antibody; proteins

Online: 17 June 2020 (08:36:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0156.v2

Delays in Initial Referral, Diagnosis and Treatment in Children with Cancer

Abbasali Hosein Pourfeizi, Rana Hosseini, Roghayeh Sheervalilou, Sahar Mehranfar

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: cancer; delay in referral; children; delay in diagnosis; delay in treatment

Online: 10 May 2020 (18:21:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201905.0328.v1

Ultrasensitive ELISA Developed for Diagnosis

Kanako Iha, Mikio Inada, Naoki Kawada, Kazunari Nakaishi, Satoshi Watabe, Yong Hong Tan, Chieh Shen, Liang-Yin Ke, Teruki Yoshimura, Etsuro Ito

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: adiponectin; diagnosis; HIV; insulin; non-amplification nucleic acid detection; ultrasensitive ELISA

Online: 28 May 2019 (10:18:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0478.v1

Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine

Noriko Kimura, Kazuhiro Takekoshi, Mitsuhide Naruse

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: pheochromocytoma; paraganglioma; GAPP; metastasis; prognosis; catecholamine; gene mutation; immunohistochemistry; pathology; diagnosis

Online: 25 July 2018 (11:41:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0473.v1

Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic

Fabio Arena, Simona Pollini, Gian Maria Rossolini, Maurizio Margaglione

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: molecular methods; virus; pandemic; Coronaviridae; COVID-19, diagnosis; UK variant; B.1.1.7 variant; 501Y.V2 variant

Online: 25 January 2021 (10:32:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0135.v1

Convolutional Neural Networks in Computer-Aided Diagnosis of Colorectal Polyps and Cancer: A Review

Kamyab Keshtkar

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: convolutional neural networks (CNNs); deep learning; computer-aided diagnosis; colorectal polyps; colorectal cancer; colonoscopy

Online: 8 October 2021 (10:50:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0244.v1

A Multi-Level System of Performance Evaluation Using Diagnosis-Related Groups for Cost Containment

Shuguang Lin, Paul Rouse, Fan Zhang, Ying-Ming Wang

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Cost containment; Performance Evaluation; Multi-level System; Diagnosis-related Group (DRG); Health system sustainability

Online: 11 May 2021 (11:29:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1371.v1

Enhancing Transformer Core Fault Diagnosis and Classification through Hilbert Transform Analysis of Electric Current Signals

Daryl Domingo, Akeem Bayo Kareem, Chibuzo Nwabufo Okwuosa, Paul Michael Custodio, Jang-Wook Hur

Subject: Engineering, Mechanical Engineering Keywords: core fault; electrical machines; fault classification; fault diagnosis; Hilbert transform; reliability; signal processing; transformer

Online: 18 January 2024 (11:31:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0098.v1

The Laboratory Diagnosis of Malaria: A Focus on the Diagnostic Assays in Non‐Endemic Areas

Adriana Calderaro, Giovanna Piccolo, Carlo Chezzi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Plasmodium sp.; imported malaria; diagnosis; molecular methods; polymerase chain reaction; RTD; microscopy; flow cytometry

Online: 1 December 2023 (16:44:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0126.v1

The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis

Sara Sacchetti, Matteo Vidali, Teresa Esposito, Stefano Zorzi, Alessia Burgener, Lorenzo Ciccarello, Gianmaria Cammarota, Valentina Zanotti, Luca Giacomini, Mattia Bellan, Mario Pirisi, Ramon Simon Lopez, Umberto Dianzani, Rosanna Vaschetto, Roberta Rolla

Subject: Biology And Life Sciences, Life Sciences Keywords: affordable health care; early diagnosis; leukocyte parameters; morphological changes; Red Cell Distribution Width (RDW); sepsis

Online: 3 January 2024 (10:04:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0752.v1

Mass Spectrometry-based Proteomic and Immunoproteomic Analyses of the Candida albicans Hyphal Secretome Reveal Diagnostic Biomarker Candidates for Invasive Candidiasis

Catarina Vaz, Aida Pitarch, Emilia Gómez-Molero, Ahinara Amador-García, Michael Weig, Oliver Bader, Lucía Monteoliva, Concha Gil

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Candida albicans; invasive candidiasis; secretome; secreted proteins; hypha; diagnosis; biomarkers; immunoproteomics; SERPA; serologic response.

Online: 31 May 2021 (11:40:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0036.v1

Painless Artificial Intelligence Point-of-Care hemogram diagnosis in Companion Animals

Teresa Guerra Barroso, Joana Maria Costa, António Hugo Gregório, Rui Costa Martins

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Point-of-care; Spectroscopy; Dog, Hemogram; Diagnosis; Painless; Reagentless; Ani- 38 mal Welfare; Artificial Intelligence.

Online: 3 January 2024 (03:51:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0042.v1

Serological and Oncoinformatic Analysis of HbA1c as a Prognostic Biomarker in Screening the Risks of Different Cancers among the Male T2D Patients of Bangladesh

Md. Al Hasibuzzaman, Salauddin Al Azad, Md. Abdur Rashid Mia, Samarth Islam, Sharmin Ahmed, Afsana Masud, Samiur Rahman, Arysha Alif Khan, Fahmida Hoque Rimti, Ashrak Shad Pyash, Partha Biswas, Homayra Rahman Shoshi, Fariha Hoque Rimu, Ramiza Nausheen Zaman, Md. Ataur Rahman, Bonglee Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HbA1c biomarker; type 2 diabetes; cancer risk profiling; serological diagnosis; oncoinformatic screening; genetic overexpression; promoter methylation

Online: 2 August 2022 (06:04:42 CEST)

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This research aimed to figure out the applications of HbA1c protein and HbA1 gene as the prognostic biomarkers for assessing the risks of different cancers among male T2D patients in Bangladesh considering their serological and oncoinformatic parameters. Depending on the concentrations of HbA1c (%) of the T2D patients (n=300), their individual FBS (mmol/L); THABF (mmol/L); creatinine (mg/dl); SC (mg/dl); STGs (mg/dl); HDLC (mg/dl); and LDLC (mg/dl) were estimated. The values of the patients were compared with the control (n=60) group as the serological analysis. Besides, HbA1 gene (encoding hBA1c protein) overexpression and promotor methylation responsible for BLCA, BRCA, CHOL, COAD, LUAD, LUSC, PAAD, and PRAD cancers in the male T2D patients were profiled as the oncoinformatic parameters based on the sample types; caner stages; racial footprints; gender; age; nodal metastasis; p53 methylations; pancreatitis; diabetes status; smoking behaviors; and overall/disease-free survivability. Finally, the ‘HbA1 gene strings’ responsible for genetic coexpression; endophytic vesicle regulation; antioxidant regulation; oxygen species metabolic regulation; and gene-mediated response to the reactive oxygen molecules were studied comprehensively. A strong correlation between BMI and FBS was observed in both the patients and the control (P<0.0001). Similarly, the values of FBS, THABF, and creatinine resulted in equal significance (P<0.0001) as compared to the HbA1c concentrations of all the T2D and control individuals. The SC, STGs, HDLC, and LDLC concentrations regulated ardently in both the control (P<0.0001), and patients group (P<0.0001), while HbA1c ranged from 3.8-5.8%, and 5.11-15.8% respectively. HbA1 gene is found downregulating with cancer progressed in most of the oncoinformatic parameters. According to the DA, CS, EI, CE, PC, NC, GF, H, and AT profiles; the HbA1 gene interacts with 8 other genes responsible for creating a protein cluster comprising- AHSP, HBA1, HBA2, HBB, HBD, HBE1, HBG2, RPS12, and RPS19 proteins for cancer formation. To recapitulate, HbA1c protein and HbA1 gene can be used as the prognostic serological and molecular biomarkers respectively for determining the risks of cancers among male chronic T2D patients.

Preprint REVIEW | doi:10.20944/preprints202306.2252.v1

May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Oesophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies

Evmorfia Psara, Sousana K. Papadopoulou, Christina Tryfonos, Maria Tolia, Aimilia-Lynn Pandi, Maria Spanoudaki, Eleni Pavlidou, Nikolaos Tsoukalas, Maria Mentzelou, Constantinos Giaginis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: nutritional assessment; oesophageal cancer; pharyngeal cancer; prognosis; survival; nutritional status; diagnosis; malnutrition; chemotherapy; radiotherapy

Online: 30 June 2023 (12:36:40 CEST)

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Background: Malnutrition in oesophageal and pharyngeal cancer patients constitutes a common and serious concern, which significantly reduces patients’ prognosis. Cancers of the oesophagus and the pharynx can considerably impair feeding in patients, resulting in severe undernutrition. This is a scoping review which aims to critically summarize and scrutinize the current clinical evidence on the use and prognostic role of diverse nutritional assessment tools on the prognosis of patients with oesophageal and pharyngeal cancers. Methods: PubMed, Scopus, Web of Science and Google Scholar databases were comprehensively explored utilizing relative keywords to detect clinical studies that investigate whether nutritional status may affect disease prognosis. Results: Several assessment tools have evaluated and highlighted the prognostic role of nutritional status on patients’ survival and disease complications in both oesophageal and pharyngeal cancers. Regarding oesophageal cancer, CONUT, PNI, PG-SGA and NRS-2002 are more commonly used, while albumin is also frequently evaluated. Regarding pharyngeal cancers, fewer studies are currently available. PNI has been evaluated and its significance as a factor for shorter overall survival, distant metastasis-free survival, progression-free survival, and locoregional recurrence-free has been highlighted. Comprehensive Nutritional Index has also been evaluated with positive results, as well as NRS 2002, GPS, and body weight status. However, there is currently a lack of studies with adequate female patients. There is also a significant lack of well-designed prospective studies with well-organized methodology. Conclusion: Nutritional status may significantly affect disease progression and patients’ survival, highlighting the importance of a good nutritional status in patients with oesophageal and pharyngeal cancers. Further large-scaled and well-designed prospective clinical studies are strongly recommended to verify the potential beneficial effects of nutritional status in patients with oesophageal and pharyngeal cancers.

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