Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Immunobiochemical Aspects in the Pathogenesis, Diagnosis, and Management of Novel Coronavirus (SARS-Cov-2) Infection

Version 1 : Received: 23 September 2020 / Approved: 24 September 2020 / Online: 24 September 2020 (04:39:38 CEST)

How to cite: Kumar Pinnelli, V.B.; Sirsikar, M.N.; Vandana, W.V.; Mohanty, S.; Silvia CR, W.D.; Mohapatra, R.K.; Vadakedath, S.; Kandi, V. Immunobiochemical Aspects in the Pathogenesis, Diagnosis, and Management of Novel Coronavirus (SARS-Cov-2) Infection. Preprints 2020, 2020090565 (doi: 10.20944/preprints202009.0565.v1). Kumar Pinnelli, V.B.; Sirsikar, M.N.; Vandana, W.V.; Mohanty, S.; Silvia CR, W.D.; Mohapatra, R.K.; Vadakedath, S.; Kandi, V. Immunobiochemical Aspects in the Pathogenesis, Diagnosis, and Management of Novel Coronavirus (SARS-Cov-2) Infection. Preprints 2020, 2020090565 (doi: 10.20944/preprints202009.0565.v1).

Abstract

Background: A new coronavirus (SARS-CoV-2) that emerged from Wuhan, Hubei Province, China, has spread throughout the world and is declared a pandemic by the World Health Organization (WHO). A lot remains to be understood of SARS-CoV-2 and the disease (COVID-19). SARS-CoV-2 has until recently been identified as responsible for both asymptomatic and serious life-threatening infections. The unavailability of specific therapeutic agents is a major hurdle in the treatment and management of COVID-19 patients. The present review attempts to evaluate the immunobiochemical aspects of the pathogenesis, diagnosis, and management of SARS-CoV-2 infection. Main Body: This review is a comprehensive evaluation of the data collected through various sources, including Google Scholar, PubMed, and Scopus. The articles were searched and selected using key words such as “Coronavirus disease (COVID-19)”, “Diagnosis of COVID-19”, Pathogenesis of Covid-19”, “management of COVID-19”, “Immunology of COVID-19”, and “Complications of COVID-19”. The study noted that the novel Coronavirus infection could result in an exaggerated immune response, causing a cytokine storm and damaging several organs of the body. The infected patients develop several complications, including immunological, hematological, and biochemical alterations. Consequently, COVID-19 patients may develop cardiovascular, liver, renal, and neurological complications, among others. Conclusion: An increased understanding of the immunobiochemical aspects of the disease may contribute to better management of SARS-CoV-2-infected persons, as evidenced from the available literature. A holistic approach to the management of COVID-19 patients taking into consideration the effect of COVID-19 infection on various organs of the body assumes increased significance in patient management.

Subject Areas

Coronavirus; SARS-CoV-2; COVID-19; Immunobiochemical aspects; pathogenesis; diagnosis; management

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