Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Coronavirus (Covid-19) Pandemic: Outbreak, Current Scenario, and Impact on Human Physiology in Pakistan

Version 1 : Received: 31 August 2020 / Approved: 2 September 2020 / Online: 2 September 2020 (09:59:45 CEST)

How to cite: Jabeen, K.; Husnain Haider, M.B.; Haider, Z.; Ali, S.; Hassan, A.; Khan Niazi, A. Coronavirus (Covid-19) Pandemic: Outbreak, Current Scenario, and Impact on Human Physiology in Pakistan . Preprints 2020, 2020090040 (doi: 10.20944/preprints202009.0040.v1). Jabeen, K.; Husnain Haider, M.B.; Haider, Z.; Ali, S.; Hassan, A.; Khan Niazi, A. Coronavirus (Covid-19) Pandemic: Outbreak, Current Scenario, and Impact on Human Physiology in Pakistan . Preprints 2020, 2020090040 (doi: 10.20944/preprints202009.0040.v1).

Abstract

Coronavirus that is also known as COVID-19 disease is produced by SARSCoV-2. This causative agent is highly contagious and can cause potentially fatal pneumonia worldwide with serious public health concerns. In the beginning among infected individuals, most of them were those who were mainly shown to the wet animal market in a big city of China known as Wuhan. So, it was suggested that this was almost certainly the zoonotic source of COVID-19illness. The transitional source of origin and their mode of transmission to humans were not known obviously. Conversely, from human to human rapidly transformation have been confirmed generally. Currently, there is no availability of FDA approved clinically antiviral drugs and/or vaccines to be used against the COVID-19. Afterward, SARS-CoV and MERS-CoV, the occurrence of SARS-CoV-2 has been manifested as the third sketch of an enormously pathogenic coronavirus into human population globally. In this review, we provide a brief overview of the history of COVID-19 in Pakistan up-to 18th weeks after beginning, current situation, epidemiology, and its impact on the human population. Moreover, we focused on physiological variation during the incubation period, genome analysis of SARS-CoV2, supportive treatment approaches, and safety measures in the Pakistani population, which may be supportive for combating the risk of COVID-19 epidemic. We also reviewed the future approaches for the development of therapeutic interventions and vaccines to cope with the COVID-19 epidemic.

Subject Areas

Coronaviruses; COVID-19; Pakistan; current situation; human physiology; diagnosis; treatment

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