Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints201906.0088.v1

LC-HRMS Screening and Identification of Novel Peptide Markers of Ricin Based on Multiple Protease Digestion Strategies

Long-Hui Liang, Chang-Cai Liu, Bo Chen, Long Yan, Hui-Lan Yu, Yang Yang, Ji-Na Wu, Xiao-Sen Li, Shi-Lei Liu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: ricin; marker peptides; unambiguous identification; mass spectrometry

Online: 11 June 2019 (08:27:32 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201801.0037.v1

Biological Effects of Amelogenin Exon 5 Encoded Peptide from Enamel Matrix Derivative in Human Dental Pulp Cells

Hirohito Kato, Yoichiro Taguchi, Kazuya Tominaga, Masahiro Noguchi, Kazutaka Imai, Ruan Yaru, Saitatsu Takahashi, Daisuke Kimura, Muneyasu Shida, Reiko Taguchi, Hiroshi Maeda, Akio Tanaka, Makoto Umeda

Subject: Chemistry And Materials Science, Biomaterials Keywords: Emdogain; amelogenin; dental pulp cells; cell differentiation; cell migration; mineralization

Online: 7 January 2018 (11:00:15 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1561.v1

Peptide-Purified Anti-N-Methyl-D-Aspartate (NMDA) Receptor Autoantibodies Have Inhibitory Effect on Long-Term Synaptic Plasticity

Charlotte Day, John-Paul Silva, Rebecca Munro, Brice Mullier, Véronique Marie André, Christian Wolff, Gary John Stephens, Angela Bithell

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: NMDA receptor autoantibodies; hippocampal neuron; long-term potentiation; multi-electrode arrays

Online: 24 April 2024 (07:28:24 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Recent studies, typically using patient cerebrospinal fluid (CSF), have suggested that different autoantibodies (Aabs) acting on their respective receptors, may underlie neuropsychiatric disorders. The NR1 subunit of the N-methyl-D-aspartate receptor (NMDAR) has been identified as a target of anti-NMDAR Aabs in a number of central nervous system (CNS) diseases including encephalitis and autoimmune epilepsy. However, the role or the nature of Aabs responsible for effects on neuronal excitability and synaptic plasticity is yet to be established fully. Patient-derived anti-NMDAR Aabs have been shown to bind to specific regions within the NR1 subunit; here, peptide immunisation was used to generate Aabs against selected specific NR1 extracellular sequences. ‘Protein A’ purification was used to obtain total IgG and further peptide purification used to obtain a greater percentage of NMDAR-target specific IgG Aabs. Binding and specificity of these anti-NMDAR Aabs was determined using a range of methodologies including enzyme-linked immunosorbent assay, immunocytochemistry and immunoblotting. Functional effects were determined using different in vitro electrophysiology techniques: two-electrode voltage-clamp in Xenopus oocytes and measures of long-term potentiation (LTP) in ex vivo hippocampal brain slices using multi-electrode arrays. We show that anti-NMDAR Aabs generated from peptide immunisation had specificity for NR1 immunisation peptides as well as target-specific binding to the native protein. Anti-NMDAR Aabs had no clear effect on isolated NMDARs in an oocyte expression system. However, we show that peptide-purified anti-NMDAR Aabs prevented the induction of LTP at Schaffer collateral-CA1 synapses in ex vivo brain slices. Our data demonstrate that anti-NMDAR Aabs cause synaptic NMDAR hypofunction at a network level. This work provides a solid basis to address outstanding questions regarding anti-NMDAR Aabs mechanisms of action and, potentially, development of therapies against CNS diseases.

Preprint ARTICLE | doi:10.20944/preprints202308.0727.v1

A Novel Antimicrobial Peptide, Dermaseptin-SS1, with Anti-Proliferative Activity, Isolated from the Skin Secretion of Phyllomedusa tarsius

Xiaonan Ma, Yuping Chen, Anmei Shu, Yangyang Jiang, Xiaoling Chen, Chengbang Ma, Mei Zhou, Tao Wang, Tianbao Chen, Chris Shaw, Lei Wang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: antimicrobial peptide; dermaseptin; molecular cloning; analogue design

Online: 9 August 2023 (10:45:09 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202307.2104.v1

Crocus sativus, Olea Europea and Salvia spp: Role in Neuroprotection against H₂O₂ and Aβ-peptide Induced Cell Toxicity

Aristidis Kofinas, Nikolaos Pavlidis, Christina E Andriopoulou, Emmanuella Epeslidou, George Leondaritis, Apostolis Aggelis, Lemonia Antoniadi, Leandros A Skaltsounis, Maria Konstandi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: salvia, olea europea, crocus sativus, oleuropein, trans-crocin, Alzheimer’s, neurotoxicity

Online: 31 July 2023 (10:45:57 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0012.v1

Non-muscle Myosin Type-II Localization in the Mouse Intestinal Villi is Altered by B-Type Natriuretic Peptide

Anteneh Addisu, Yunus E. Dogan, Darrice Montgomery, Leeyu Addisu, Abdel A Alli

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Non-Muscle Myosin; BNP; GI epithelia; Apical junctional complex; Absorption

Online: 1 May 2023 (04:09:57 CEST)

Show abstract| Download PDF| Share

Our prior studies have shown that B type Natriuretic Peptide (BNP) decreases absorption from the gastrointestinal (GI) tract. Since non-muscle myosin-type II (NMM-II) is known to have a role in epithelial tight junction regulation, we aimed to test whether BNP has an effect on the localization and expression of NMM-II in the intestinal villi. We treated wild type mice with a 10 ng/g intravenous bolus of BNP followed by infusion of BNP at 1ng/g/minute vs. vehicle control. The mice were then euthanized and intestinal tissue isolated and sectioned. The tissue was immune-stained for NMM-II and examined using fluorescence microscopy. The tissue section not treated with antibody to NMM-II was used as a methodological control to evaluate the non-specific binding. Scanning electron micrographic images were taken to compare structural differences between the two groups. Western blotting was performed to compare the regional protein expression of NMM-II and associated proteins including smooth muscle actin, kinesin, and E cadherin in small intestinal tissue between BNP vs. vehicle infused mice. Fluorescence microscopy revealed markedly increased localization of NMM-II at the crypts and core of intestinal villi of the jejunum, ileum and colon of BNP treated mice compared to vehicle. Transmission electron microscopy revealed that the microvilli of BNP treated mice assumed the distinctive appearance of ‘relaxed’ microvilli compared to vehicle. Such decrease in contractility was previously shown to decrease para-cellular permeability of epithelia. Our observation indicates that BNP alters the localization of NMM-II in intestinal villi and makes the intestinal villi structures assume a state of decreased permeability of the apical junctional complex. Further characterization of this process and understanding the specific mediators involved could lead to the identification of novel therapeutic targets for various disease states such as heart failure and malabsorption.

Preprint ARTICLE | doi:10.20944/preprints202301.0373.v1

No Chance to Survive: Mo-CBP3-PepII Synthetic Peptide Acts on Cryptococcus neoformans by Multiple Mechanisms of Action

Tawanny K.B. Aguiar, Felipe P. Mesquita, Nilton A. S. Neto, Francisco I. R. Gomes, Cleverson D. T. Freitas, Rômulo F. Carneiro, Celso S. Nagano, Luciana M.R. Alencar, Ralph Santos-Oliveira, Jose T. A. Oliveira, Pedro F. N. Souza

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: alternative drugs; cryptococcosis; oxidative stress; synthetic peptides

Online: 20 January 2023 (15:17:15 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0191.v1

Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical vein Blood in Type-1 Diabetes

Josip Delmis, Slavko Oreskovic, Vesna Elvedji Gasparovic, Mirta Starcevic, Mislav Herman, Nada Dessardo, Vito Starcevic, Marina Ivanisevic

Subject: Biology And Life Sciences, Food Science And Technology Keywords: BDNF; CRP; C-peptide; leptin; pregnancy; skinfold thickness; thyroid hormones; type-1 diabetes mellitus

Online: 11 January 2023 (02:57:33 CET)

Show abstract| Download PDF| Share

Working Paper CASE REPORT

CIGB-258, An Immunomodulatory Peptide for the Treatment of a COVID-19-associated Hepatic Encephalopathy: A Case Report

Maria del Carmen Dominguez-Horta

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; hepatic encephalopathy; CIGB-258

Online: 11 September 2020 (05:49:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201907.0180.v1

Lupine (Lupinus angustifolius L.) Peptide Prevents Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice

Ana Lemus-Conejo, Elena Grao-Cruces, Rocio Toscano, Lourdes M Varela, Carmen Claro, Justo Pedroche, Francisco Millan, Maria C Millan-Linares, Sergio Montserrat-de la Paz

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: GPETAFLR peptide; protein hydrolysate; liver; hepatic steatosis; high-fat diet

Online: 15 July 2019 (06:09:04 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201801.0149.v1

Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

Ming Bi, Hui Han, Shujun Dong, Ying Zhang, Weiguo Xu, Bitao Zhu, Jingyun Wang, Yanmin Zhou, Jianxun Ding

Subject: Chemistry And Materials Science, Biomaterials Keywords: porous scaffold; collagen coating; bioactive peptide; skull defect repair; tissue engineering

Online: 17 January 2018 (06:48:17 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0360.v1

Intranasal Delivery of Cell-Penetrating Therapeutic Peptide Enhances Brain Delivery, Reduces Inflammation, and Improves Neurologic Function in Moderate TBI

Yaswanthi Yanamadala, Ritika Roy, Afrika Williams, Navya Uppu, Audrey Yoonsun Kim, Mark A DeCoster, Paul Kim, Teresa Ann Murray

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Traumatic brain injury; TBI; secondary injury; peptide therapeutics; cell penetrating peptide; pro-inflammatory cytokines; intranasal drug delivery; blood brain barrier

Online: 7 May 2024 (11:13:30 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0817.v1

The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects

Zsófia Clemens, Andrea Dabóczi, Enikő Andrásofszky, Mária Schimmer, Natalie Daniels, Orsolya Szathmári, Erika Fésüs, Réka Horváth

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: C-peptide; paleolithic ketogenic diet; diabetes; T1DM; low-carbohydrate diet; insulin

Online: 12 December 2023 (11:15:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0004.v1

Neuroprotective Effects of a Serotonin Receptor Peptide Follow-ing Sham vs. Mild Traumatic Brain Injury in the Zucker Rat

Mihal Grinberg, Julia Burton, Kevin CH Pang, Mark B Zimering

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: neurodegeneration; traumatic brain injury; Zucker rat; Autoantibodies; serotonin 2A receptor

Online: 1 May 2023 (03:09:43 CEST)

Show abstract| Download PDF| Share

Aims: Anxiety, major depressive disorder and accelerated cognitive decline frequently complicate traumatic brain injury. Obesity and type 2 diabetes mellitus drive peripheral inflammation which can accelerate traumatic brain injury-associated neurodegeneration. The Zucker rat harbors G-protein coupled receptor agonist IgG autoantibodies and in vitro neurotoxicity caused by these autoantibodies was prevented by a novel synthetic fragment of the serotonin 2A receptor. The aim of the present study was to test whether genetic obesity manifested in Zucker diabetic fatty rat is associated with anxiety, depression and spatial memory impairment induced by mild traumatic brain injury. Furthermore, we investigated whether these neurobehavioral or neurodegenerative complications can be lessened by administration of a novel putative neuroprotective peptide. Methods: Age-matched lean and fatty diabetic Zucker rats were tested in the sucrose preference test (anhedonia), open field test in bright light (anxiety measure) and the Morris water maze (spatial memory) prior to receiving a sham-injury or lateral fluid percussion (LFP) mild traumatic brain injury. Behavioral testing was repeated at 1-week, 1-month, and 3-month intervals following injury. A synthetic peptide consisting of a portion of the 5- hydroxytryptamine (serotonin) 2A receptor (2 mg/kg) (or vehicle) was administered via intraperitoneal route every other day for 7 days after sham or LFP injury to lean rats or 7 days before and after sham or LFP injury to fatty rats. Results: Sucrose preference decreased transiently (one week after mild traumatic brain injury) in Zucker lean rats indicative of anhedonia. Baseline anxiety-like behavior (bright light, open field test) was lower in fatty vs. lean Zucker rats, and anxiety behavior increased significantly in fatty rats but not lean rats following mild traumatic brain injury. Mild traumatic brain injury impaired recall of spatial memory in fatty and lean rats, and the effect was longer-lasting in fatty rats. A synthetic peptide fragment of the 5-hydroxytryptamine 2A receptor enhanced recall of spatial learning one-week after sham injury in Zucker rats and it may have prevented ‘anhedonia’ one-week after TBI (LFP) in a subset of Zucker fatty and lean rats expressing near-normal baseline sucrose preference. Mean plasma 5-hydroxytryptamine 2A receptor autoantibody level (determined 2 weeks after injury) was 2.5-fold higher than background, but did not differ significantly in (sham- vs TBI) Zucker lean rats. Conclusions: These are the first data to suggest reduced baseline anxiety-like behavior in Zucker fatty (vs. lean) rats. The pronounced increases in anxiety , and spatial memory impairment experienced by Zucker fatty (vs lean) rats following mild traumatic brain injury may have accounted in part for absence of a 5-hydroxytryptamine 2A receptor peptide neuroprotective effect in brain- injured Zucker fatty rats.

Preprint ARTICLE | doi:10.20944/preprints202104.0512.v1

HBV Pre-S1-Derived Myristoylated Peptide (Myr47): Identification of the Inhibitory Activity on the Cellular Uptake of Lipid Nanoparticles

Masaya Nanahara, Ya-Ting Chang, Masaharu Somiya, Shun’ichi Kuroda

Subject: Chemistry And Materials Science, Biomaterials Keywords: hepatitis B virus (HBV); Myr47 lipopeptide; cellular uptake; liposomes; sodium taurocholate cotransporting polypeptide (NTCP); HBV surface antigen (HBsAg); apolipoprotein E (ApoE)

Online: 19 April 2021 (17:08:53 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0445.v1

The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future.

Virginia Liberini, Martin W. Hüllner, Serena Grimaldi, Monica Finessi, Philippe Thuillier, Alfredo Muni, Riccardo E. Pellerito, Mauro Papotti, Alessandro Piovesan, Emanuela Arvat, Désirée Deandreis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Peptide Receptor Radionuclide Therapy; PRRT; 68Ga-labeled somatostatin analogue; 18F-FDG; response assessment; RECIST; SWOG; WHO; neuroendocrine tumors; NET

Online: 17 November 2020 (10:35:21 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

RNA/Peptide Editing in Small Soluble Binding Proteins: A New Theory for the Origin of Life on Earth's Crust

Jean-Francois Picimbon

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Insecta; Chemosensory proteins; Odorant binding proteins; Peptide mutation; Cell evolution; Abiogenesis

Online: 30 January 2020 (03:02:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201806.0244.v1

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁵⁸-K⁵⁹ Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

Stefan Sikorra, Martin Skiba, Martin B. Dorner, Jasmin Weisemann, Mirjam Weil, Sylvia Valdezate, Bazbek Davletov, Andreas Rummel, Brigitte G. Dorner, Thomas Binz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Clostridium botulinum; botulinum neurotoxin; serotype F; subtype; VAMP-2; synaptobrevin; Zn2+ protease

Online: 15 June 2018 (05:32:49 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1201.v1

Antibacterial and Anti-quorum Sensing Activity of PAMAM G4 Loaded Quorum Quencher Peptide against MRSA, Staphylococcus aureus and Agr Mutants

Naifa A. Alenazi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Methicillin-resistant Staphylococcus aureus; poly-amidoamine dendrimers (PAMAM); anti-virulence agent, accessory gene regulator; histidine kinase inhibitor.

Online: 16 August 2023 (20:32:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0466.v1

Expanding the Analytical Toolbox: Developing New Peptide Map Methods to Fully Characterize the Proteolysis-resistant Single-domain Antibody New Modality

Y Diana Liu, Michelle Irwin Beardsley, Feng Yang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Biopharmaceuticals; drug substances; sample preparation; mass spectrometry

Online: 7 August 2023 (10:01:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1403.v1

Liposome Nanoparticle Conjugation and Cell Penetrating Peptide Sequences (CPPs) Enhance the Cellular Delivery of the Tau Aggregation Inhibitor RI-AG03

Niklas Reich, David Allsop, Edward Parkin, Neil Dawson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s Disease; Tauopathy; Cell penetrating peptide; Polyarginine; TAT; Liposomes; Nanoparticles; Tau pathology; Tau aggregation inhibitor; Endocytosis

Online: 19 May 2023 (08:06:10 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint COMMUNICATION | doi:10.20944/preprints202104.0518.v1

Solid Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond

Krzysztof Kaczmarek, Barbara Pacholczyk-Sienicka, Łukasz Albrecht, Janusz Zabrocki, Ronald Nachman

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: insect neuropeptides; pyrokinins; trans peptide bond; imidazoline ring; SPOS;

Online: 19 April 2021 (21:18:57 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

Delineating Blueprint of an Epitope-Based Peptide Vaccine against the Multiple Serovars of Dengue Virus: A Hierarchical Reverse Vaccinology Approach

Rahatul Islam, Md. Sorwer Alam Parvez, Saeed Anwar, Mohammad Jakir Hosen

Subject: Biology And Life Sciences, Virology Keywords: Dengue virus; multiple serovars; Epitopes; Vaccine

Online: 31 May 2020 (18:28:15 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201808.0527.v1

The Effects of Amelogenin Exon 5 Encoded Peptide from Enamel Matrix Derivative Enhances in Odontoblast like Cells, KN-3 Cells

Hirohito Kato, Yoichiro Taguchi, Kazuya Tominaga, Kazutaka Imai, Yaru Ruan, Masahiro Noguchi, Yu-wei Tsai, Yi-Chie Chen, Muneyasu Shida, Reiko Taguchi, Hiroshi Maeda, Akio Tanaka, Makoto Umeda

Subject: Chemistry And Materials Science, Biomaterials Keywords: emdogain; amelogenin; odontoblast; differentiation; mineralization

Online: 30 August 2018 (13:01:52 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0469.v1

In Search for the Low-Molecular-Weight Ligands of Human Serum Albumin that Affect its Affinity for Monomeric Amyloid β Peptide

Evgenia I. Deryusheva, Marina P. Shevelyova, Victoria A. Rastrygina, Ekaterina L. Nemashkalova, Alisa A. Vologzhannikova, Andrey V. Machulin, Alija A. Nazipova, Maria E. Permyakova, Sergei E. Permyakov, Ekaterina A. Litus

Subject: Biology And Life Sciences, Biophysics Keywords: Alzheimer’ s disease; amyloid β peptide; human serum albumin; low-molecular-weight ligand; protein-ligand interaction; surface plasmon resonance spectroscopy

Online: 7 April 2024 (10:18:10 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201908.0090.v1

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

Masari Otsuki, Noboru Fukuda, Takashi Inoue, Takayuki Mineshige, Tomoyasu Otsuki, Shu Horikoshi , Morito Endo, Masanori Abe

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: human; TGF-β1; pyrrole-imidazole polyamide; renal disease; marmoset

Online: 7 August 2019 (09:42:06 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0286.v1

Obtaining of New Antioxidant and Antimicrobial Peptides Derived from Human Hemoglobin by Peptide Hydrolysis and Comparison with These Obtained by Bovine Hemoglobin

Ahlam Outman, Barbara Deracinois, Christophe Flahaut, Mira Abou Diab, Jihen Dhaouefi, Bernard Gressier, Bruno Eto, Naima Nedjar

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: human hemoglobin; bovine hemoglobin; bioactive peptides; antibacterial activity; antioxidant activity

Online: 6 July 2023 (02:12:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202210.0050.v1

Comparative Preclinical Evaluation of Peptide-Based Chelators for Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in Cancer

Maria Larkina, Evgenii Plotnikov, Ekaterina Bezverkhniaia, Yulia Shabanova, Maria Tretyakova, Feruza Yuldasheva, Roman Zelchan, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Javad Garousi, Torbjörn Gräslund, Mikhail Belousov, Vladimir Tolmachev, Sergey M. Deyev

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: radionuclide; HER2; DARPin; SPECT; 99mTc; imaging; cancer

Online: 6 October 2022 (08:09:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0143.v1

Immunoinformatic Guided Rational Design of a Next Generation Multi Epitope Based Peptide Vaccine against Marburg Virus Disease Combined with Molecular Docking Studies

Mujahed Mustafa, Shaza Shantier

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Marburg virus disease (MVD); Vaccine design; Immunoinformatic; Molecular Docking Study.

Online: 10 May 2022 (14:16:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1507.v1

Clinical Utility of Baseline Brain Natriuretic Peptide Levels on Health Status Outcomes after Catheter Ablation for Atrial Fibrillation in Individuals without Heart Failure

Shin Kashimura, Nobuhiro Ikemura, Shun Kohsaka, Yoshinori Katsumata, Takehiro Kimura, Daisuke Shinmura, Kotaro Fukumoto, Koji Negishi, Ikuko Ueda, Seiji Takatsuki, Masaki Ieda

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; brain natriuretic peptide; catheter ablation; non–heart failure; quality of life

Online: 20 December 2023 (10:56:19 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0734.v1

AE36 HER2/neu-derived Peptide Linked to Positively Charged Liposomes with CpG-ODN as an Effective Therapeutic and Prophylactic Vaccine for Breast Cancer

Nastaran Barati, Amin Reza Nikpoor, Fatemeh Mosaffa, Atefeh Razazan, Ali Badiee, Mousa Motavallihaghi, Javad Behravan, Mahmoud Reza Jafari

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: AE36 HER2/neu-derived peptide; Nanoliposomes; CpG-ODN; Vaccine; Cancer

Online: 30 September 2020 (10:12:34 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202007.0178.v2

Brief Report: Rapid Clinical Recovery from Critical COVID-19 with Respiratory Failure in a Lung Transplant Patient Treated with Intravenous Vasoactive Intestinal Peptide

Jihad Georges Youssef, Faisal Zahiruddin, Mukhtar Al-Saadi, Simon Yau, Ahmad Goodarzi, Howard J. Huang, Jonathan C. Javitt

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Aviptadil; Vasoactive Intestinal Peptide; VIP; SARS-CoV-2; COVID-19; Corona Virus; Acute Respiratory Distress Syndrome; ARDS; Acute Lung Injury; ALI; surfactant; Alveolar Type II; ATII

Online: 2 August 2020 (18:16:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201812.0203.v1

The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code

Sankar Chatterjee, Surya Yadav

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: peptide/RNA world; prebiotic information system; translation and the genetic code; coevolution of translation machine and the genetic code; MVC architecture pattern and biological information; numerical codons; AnyLogic software for computer simulation of translation machine

Online: 17 December 2018 (16:03:16 CET)

Show abstract| Download PDF| Supplementary Files| Share

Information is the currency of life, but the origin of prebiotic information remains a mystery. We propose transitional pathways from the cosmic building blocks of life to the complex prebiotic organic chemistry that led to the origin of information systems. The prebiotic information system, specifically the genetic code, is segregated, linear, and digital and probably appeared during biogenesis four billion years ago. In the peptide/RNA world, lipid membranes randomly encapsulated amino acids, RNA, and protein molecules, drawn from the prebiotic soup, to initiate a molecular symbiosis inside the protocells. This endosymbiosis led to the hierarchical emergence of several requisite components of the translation machine: tRNAs, aaRS, mRNAs, and ribosomes. When assembled in the right order, the translation machine created biosynthetic polypeptides, a process that transferred information from mRNAs to proteins. This was the beginning of the prebiotic information age. The molecular attraction between tRNA and amino acids led to different stages of the translation machines and the genetic code. tRNA is an ancient molecule that designed and built mRNA for storing the information of its cognate amino acid. Each mRNA strand became the storage device for the genetic information that encoded the amino acid sequences in triplet nucleotides. As information appeared in the digital languages of the codon within mRNA, and the genetic code for protein synthesis evolved, the prebiotic chemistry then became more organized and directional. The origin of the genetic code is enigmatic; herein we propose an evolutionary explanation: the demand for a wide range of specific enzymes in the peptide/RNA world was the main selective pressure for the origin of information-directed protein synthesis. We review three main concepts on the origin and evolution of the genetic code: the stereochemical theory, the coevolution theory, and the adaptive theory. These three theories are compatible with our coevolution model of the translation machines and the genetic code. We suggest biosynthetic pathways as the origin of the specific translation machines which provided the framework for the origin of the genetic code. During translation, the genetic code developed in three stages coincident with the refinement of the translation machines: GNC code developed by the pre-tRNA/pre-aaRS /pre-mRNA machine, SNS code by the tRNA/aaRS/mRNA machine, and finally the universal genetic code by the tRNA/aaRS/mRNA/ribosome machine. Our hypothesis provides the logical and incremental steps for the origin of the programmed protein synthesis. In order to understand the prebiotic information system better, we converted letter codons into numerical codons in the Universal Genetic Code Table. We have developed a software called CATI (Codon-Amino Acid-Translator-Imitator) to translate randomly chosen numerical codons into corresponding amino acids and vice versa. This conversion has granted us insight into how the translation might have worked in the peptide/RNA world. There is great potential in the application of numerical codons to bioinformatics such as barcoding, DNA mining, or DNA fingerprinting. We constructed the likely biochemical pathways for the origin of translation and the genetic code using the Model-View-Controller (MVC) software framework, and the translation machinery step-by-step. Using AnyLogic software we were able to simulate and visualize the entire evolution of the translation machines and the genetic code. The results indicate that the emergence of the information age from the peptide/RNA world was a watershed event in the origin of life about four billion years ago.

Preprint ARTICLE | doi:10.20944/preprints201805.0356.v1

A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria

Ammar Almaaytah, Ahmad Farajallah, Ahmad Abualhaijaa, Qosay Al-balas

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Scoprion Venoms; Hos Defence Peptides; antimicrobial activity; antibiofilm activity; synergism; bacterial resistance

Online: 25 May 2018 (09:26:11 CEST)

Show abstract| Download PDF| Share

Current research in the field of antimicrobials is focused on the development of novel antibiotics and antimicrobial agents to counteract the huge dilemma that the human population is mainly facing in regards to the rise of bacterial resistance and biofilm infections. Host Defense peptides (HDPs) are a promising group of molecules for antimicrobial development as they share unique characteristics suitable for antimicrobial activity including their broad spectrum of activity and potency against bacteria. AamAP1 is a novel HDP that was identified through molecular cloning from the venom of the North African scorpion Androctonus amoeruxi. In vitro antimicrobial assays revealed that the peptide displays moderate activity against different strains of Gram-positive and Gram-negative bacteria. Additionally, the peptide proved to be highly hemolytic and displaying significantly high toxicity against mammalian cells. In our study, a novel synthetic peptide analogue named A3 was designed from the naturally occurring scorpion venom host defense peptide. The design strategy depended on modifying the amino acid sequence of the parent peptide in order to increase its net positive charge, percentage helicity and optimize other physico-chemical parameters involved theoretically in HDPs activity. Accordingly, A3 was evaluated for its in vitro antimicrobial and anti-biofilm activity individually and in combination with four different types of conventional antibiotics against clinical isolates of multi-drug resistant (MDR) Gram-positive bacteria. A3 was also evaluated for its cytotoxicity against mammalian cells. A3 displayed potent and selective in vitro antimicrobial activities against a wide range of MDR Gram-positive bacteria. Our results also showed that combining A3 with conventional antibiotics displayed a synergistic mode of action which resulted in decreasing the MIC value for A3 peptide as low as 0.125 µM. These effective concentrations were associated with negligible toxicities on mammalian cells. In conclusion, A3 exhibits enhanced activity and selectivity when compared with the parent natural scorpion venom peptide. The combination of A3 with conventional antibiotics may be pursued as a potential novel treatment strategy against MDR and biofilm forming bacteria.

Preprint ARTICLE | doi:10.20944/preprints201710.0180.v1

Low Levels of IgG Recognizing the Alpha-1-Antitrypsin (A1AT) ^50-63 Peptide and Its Association with Taiwanese Women with Primary Sjögren's Syndrome

Yu-Sheng Chang, Chih-Hong Pan, Che-Chang Chang, Kai-Leun Tsai, Han-Wen Chou, Jin-Hua Chen, Sheng-Hong Lin, Yi-Ying Lu, Chih-Chun Tai, Yi-Fang Lin, Ching-Yu Lin

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: primary Sjögren's syndrome; alpha-1-antitrypsin; inhibitor; 4-hydroxy-2-nonenal; autoantibody isotypes; serum

Online: 30 October 2017 (04:30:59 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0359.v1

In Silico Identification of Novel B Cell and T Cell Epitopes of Wuhan Coronavirus (2019-nCoV) for Effective Multi Epitope-Based Peptide Vaccine Production

Muhammad Asif Rasheed, Sohail Raza, Ali Zohaib, Tahir Yaqub, Masood Rabbani, Muhammad Ilyas Riaz, Muhammad Awais, Amna Afzal

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: novel coronavirus; Wuhan; vaccine; epitopes; peptide

Online: 25 February 2020 (05:18:22 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1697.v1

Potential of Human Hemoglobin as a Source of Bioactive Peptides: Comparative Study of Enzymatic Hydrolysis with Bovine Hemoglobin and Production of Active Peptide α137-141.

Ahlam Outman, Barbara Deracinois, Christophe Flahaut, Mira Abou Diab, Bernard Gressier, Bruno Eto, Naima Nedjar

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Bovine hemoglobin; Human hemoglobin; Bioactives peptides; Neokyotorphin

Online: 24 June 2023 (15:06:20 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Cruor, the main component responsible for the red color of blood in mammals, contains 90% hemoglobin, a protein that is considered a rich source of bioactive peptides. The aim of the present study is to evaluate the potential of human hemoglobin as a source of bioactive peptides, compared to bovine hemoglobin, which has been widely studied in recent years. More specifically, the study focused on neokyotorphin, a natural antimicrobial peptide and meat preservative, which corresponds to the α137-141 fragment of bovine hemoglobin produced by enzymatic hydrolysis. Firstly, the results of the in-silico analysis showed that the two types of hemoglobin have a high similarity for the α and β chains (identities of 88% and 91%, respectively). Secondly, both types of hemoglobin were subjected to similar enzymatic hydrolysis conditions, which showed that the hydrolysis of human hemoglobin followed the same reaction mechanism as the hydrolysis of bovine hemoglobin, the 'Zipper' mechanism. The hydrolysis conditions (23°C, pH 3.5) made it possible to obtain α137-141 in significant quantities to allow for significant valorization from an industrial point of view. The hydrolyses were able to take place at high initial substrate concentrations, allowing for faster and more efficient processing of the co-product in the same amount of time, with over 65% of this production achieved in just 30 min. Increasing the substrate concentration (from 1% to 10% (w/v)) resulted in a proportional increase in α137-141 production. Regardless of the concentrations tested, the kinetic pattern remained similar. Finally, the results of the mass spectrometry analysis revealed the presence of several bioactive peptides in cattle and humans. Although some were known before, new bioactive peptides were discovered in human hemoglobin, such as four antibacterial peptides (α37-46 PTTKTYFPHF; α36-45 FPTTKTYFPH; α137-141 TSKYR; α133-141 STVLTSKYR), four opioid peptides (α137-141 TSKYR; β31-40 LVVYPWTQRF; β31-37 LVVYPWT), an ACE inhibitor (β129-135 KVVAGVA), an anticancer agent (β33-39 VVYPWTQ) and an antioxidant (α137-141 TSKYR). These peptides have never been found in human hemoglobin before, according to our knowledge. These results highlight the potential of human hemoglobin as a source of bioactive peptides useful for the food or pharmaceutical industry.

Preprint ARTICLE | doi:10.20944/preprints202311.1030.v1

Recombinant Human Peptide Growth Factors rhBMP7 (Bone Morphogenetic Protein 7) and rhPDGF-BB (Platelet-Derived Growth Factor BB) for Osteoporosis Treatment in an Oophorectomized Rat Model

Thamara Gonçalves Reis, Alice Marcela Sampaio Del Colletto, Luiz Augusto Santana Silva, Bruna Aguiar Andrade Koga, Mari Cleide Sogayar, Ana Claudia Oliveira Carreira

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Osteoporosis; BMP-7; PDGF-BB; peptide growth factors; bone repair.

Online: 15 November 2023 (15:50:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0139.v1

ACTH(6-9)PGP Peptide Protects SH-SY5Y Cells from the H2O2, tert-Butyl Hydroperoxide, and Cyanide Cytotoxicity via Prolif-eration Stimulation and Antioxidant-related Genes Induction

Mikhail G. Akimov, Elena V. Fomina-Ageeva, Polina V. Dudina, Ludmila A. Andreeva, Nikolay F. Myasoyedov, Vladimir V. Bezuglov

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: ACTH(6-9); Neuroprotection; MPP+; H2O2; tert-butyl hydroperoxide; cyanide; melanocortins; oxidative stress

Online: 3 March 2021 (16:49:08 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202007.0488.v1

D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV

Babu Bassa, Brown Olen

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV; SARS-CoV; COVID-19; Sarbecovirus; D614G; Spike glycoprotein; Coronavirus; Alignment-free

Online: 21 July 2020 (12:47:13 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202311.1400.v1

Preclinical and Clinical Observations Implying Combination Therapy to Enhance the Efficacy of the Her-2/Neu B Cell Peptide-Based Vaccine Her-Vaxx and to Prevent Immune Evasion

Joshua Tobias, Sandra Högler, Martin Raigel, Diego Shih-Chieh Lin, Yee Chao, Lukas Kenner, Erika Garner-Spitzer, Sharon Yavrom, Nicholas J. Ede, Christoph C. Zielinski, Michael Kundi, Ursula Wiedermann

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PD-L1; Her-2/neu; Expression; Preclinical and clinical settings; Immune evasion; Combination therapy

Online: 22 November 2023 (07:30:25 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202401.2063.v1

In Vivo and In Vitro Evaluation of the Antibacterial Activity of the Synthetic Peptide LyeTx I mn∆K, Derived From Lycosa erythrognatha Spider Toxin, Against Methicillin-Resistant Staphylococcus aureus (MRSA)

Ana Paula Gonçalves Coelho Vieira, Amanda Neves De Souza, William Gustavo Lima, Julio Cesar Moreira Brito, Daniela Carolina Simião, Lucas Vinicius Ribeiro Gonçalves, Lídia Pereira Barbosa Cordeiro, Denise de Oliveira Scoaris, Simone Odília Antunes Fernandes, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly, Maria Elena De Lima

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Antimicrobial peptides; Methicillin-resistant Staphylococcus aureus (MRSA); Lycosa erythrognatha; Skin infections; Action on membrane.

Online: 30 January 2024 (05:00:30 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0509.v1

The Dry Extracts of Matricaria discoidea DC. Herb with Analgesic and Soporific Activity: Phytochemical, Pharmacological and Molecular Docking Research

Janne Sepp, Oleh Koshovyi, Valdas Jakštas, Vaidotas Žvikas, Iryna Botsula, Igor Kireyev, Hanna I. Severina, Oleksandr Kukhtenko, Kaisa Põhako-Palu, Karin Kogermann, Jyrki Heinämäki, Ain Raal

Subject: Medicine And Pharmacology, Pharmacy Keywords: pineapple weed; herb; extraction; terpenoids; polyphenols; cytotoxicity; analgesic activity; soporific effect

Online: 8 February 2024 (10:18:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0420.v1

On the Profuse Lanthanide Effect on Functional Properties of 0.94Na_0.5Bi_0.5TiO₃-0.06BaTiO₃ Ceramic

Jacem Zidani, Ilham Hamdi Alaoui, Moneim Zannen, Eriks Birks, Zakaria Chchiyai, Mustapha Majdoub, Bouchaib Manoun, Mimoun El Marssi, Abdelilah LAHMAR

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: Sodium Bismuth Titanate; structural refinement; dielectric properties; ferroelectric properties; piezoelectric properties; Photoluminescence

Online: 7 March 2024 (10:49:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0685.v1

Performance Analysis of Dipole Antenna Applications: A Literature Review

Christian Lly Sosa, Edwin Arboleda

Subject: Telecommunications, Engineering Keywords: Dipole antennas, Performance analysis, Wireless communication, Impedance matching, Optimization techniques

Online: 10 May 2024 (20:08:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0702.v1

Design and Implementation Low-Power Device for Non-Invasive Blood Glucose

Luis Miguel Pires, José Martins

Subject: Bioengineering, Engineering Keywords: Blood glucose monitoring; Embedded systems; Heartbeat sensor; Near-IR sensors

Online: 10 May 2024 (20:06:26 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0684.v1

Effects of  Phase and Annealing Twins on Mechanical Properties and Impact Toughness of L-PBF Inconel 718

Wakshum Mekonnen Tucho, Bjorn Andre Ohm, Sebastian Andres Pedraza Canizalez, Andreas Egeland, Martin Bernard Mildt, Mette Lokna Nedreberg, Vidar Folke Hansen

Subject: Metallurgy And Metallurgical Engineering, Engineering Keywords: L-PBF; Inconel 718; microstructure; heat treatment; mechanical strength; microscopy

Online: 10 May 2024 (20:05:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0682.v1

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

Robert S Thompson, Samuel J Bowers, Fernando Vargas, Shelby Hopkins, Tel Kelley, Antonio Gonzalez, Christopher A Lowry, Pieter C Dorrestein, Martha Hotz Vitaterna, Fred Turek, Rob Knight, Kenneth P Wright Jr., Monika Fleshner

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: microbiome; metabolome; prebiotic; polydextrose; galactooligosaccharide; Parabacteroides; Ruminiclostridium 5; bile acid; deoxycholic acid

Online: 10 May 2024 (20:04:16 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0679.v1

Low Vitamin D Concentration is Associated with Increased Depression Risk in Adults 20-44 Years-Old, an NHANES 2007-2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status

Victoria Rose Barri Benters Hollinshead, Julia L. Piaskowski, Yimin Chen

Subject: Dietetics And Nutrition, Medicine And Pharmacology Keywords: 25OHD2; 25OHD3; Pregnant; Postpartum; Women; Diet patterns; Mental health; PHQ-9; Depressive symptoms; Human milk

Online: 10 May 2024 (20:02:58 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0687.v1

Luisa Fernanda Duque-Buitrago, Iraham Enrique Solorzano-Lugo, Marcela González-Vázquez, Cristian Jiménez-Martínez, María Antonia Hernández-Aguirre, Perla Osorio-Díaz, Georgina Calderón-Domínguez, Veronica Loera-Castañeda, Rosalva Mora-Escobedo

Subject: Food Science And Technology, Biology And Life Sciences Keywords: Agave atrovirens; Opuntia spp.; cactus pear; agave sap; colonic fermentation; carbohydrates; phenolic compounds; short-chain fatty acids

Online: 10 May 2024 (20:01:53 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0721.v1

Rapid Modeling Method for Airborne FSS Radomes Based on Dynamic Customizable Primitives

Cunai Qiu, Shen Li, Wenwu Zhang, Liwei Song, Xiang Li, Zhongen Yan, Yue Chen, Saisai Suo

Subject: Mechanical Engineering, Engineering Keywords: airborne frequency selective surface radome (AFSSR); primitives; rapid modeling

Online: 10 May 2024 (20:00:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0693.v1

India Environmental Policy: A Systematic Literature Review impact of Air Pollution toward Taj Mahal

Mujiburrahman Mujiburrahman, Ashabul Kahffi, Eka Januar, Raegen Harahap

Subject: Pollution, Environmental And Earth Sciences Keywords: Taj Mahal; Environmental; Pollution; Policy; Climate Change.

Online: 10 May 2024 (19:56:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0695.v1

Seismic Capacity Evaluation of Reinforced Concrete Moment-Resisting Frames with Steel Damper Columns using Incremental Critical Pseudo-Multi Impulse Analysis

Kenji Fujii

Subject: Architecture, Building And Construction, Engineering Keywords: reinforced concrete moment-resisting frame; steel damper column; seismic capacity; pseudo-multi impulse (PMI); incremental critical pseudo-multi impulse analysis (ICPMIA); maximum momentary input energy; peak displacement

Online: 10 May 2024 (19:55:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0697.v1

Reduced Pharmacological Intervention of Prehospital Services for Acute Alcohol Intoxication during the COVID-19 Pandemic in a Large District of Southern Italy

Arcangela Giustino, Annamaria Natola, Giovanni Savoia, Maria Antonietta De Salvia, Carmine Finelli

Subject: Internal Medicine, Medicine And Pharmacology Keywords: emergency service; acute alcohol intoxication; triage; pharmacological treatment; public health

Online: 10 May 2024 (18:32:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0719.v1

Numerical Study of Concrete: A Mesoscopic Scale Simulation Methodology

Zulima Fernández-Muñiz, Francisco Montero-Chacón, Mar Alonso Martínez, Juan José del Coz-Diaz, Carlos López-Colina Pérez, Fernando López-Gayarre

Subject: Civil Engineering, Engineering Keywords: mesoscopic scale; numerical model; concrete behavior

Online: 10 May 2024 (18:31:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0717.v1

Thermal Emittance Measurement of Very Low-Emissive Materials for Solar Thermal Applications

Eliana Gaudino, Umar Farooq, Antonio Caldarelli, Paolo Strazzullo, Daniela De Luca, Emiliano Di Gennaro, Marilena Musto, Roberto Russo

Subject: Other, Engineering Keywords: thermal emittance; calorimetric measurements procedure; selective solar absorbers; high vacuum flat plate collectors; very low thermal emittance

Online: 10 May 2024 (18:30:28 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202405.0708.v1

Impact of the Implementation of the Deposit Refund System on Coastal Littering in Latvia

Janis Brizga, Janis Ulme, Anna Larsson

Subject: Waste Management And Disposal, Environmental And Earth Sciences Keywords: deposit refund system; coastal littering; waste management

Online: 10 May 2024 (18:29:03 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0660.v1

Catch of Reesa vespulae in Heritage Environments

Peter Brimblecombe, Pascal Querner

Subject: Insect Science, Biology And Life Sciences Keywords: parthenogenesis; skin beetle; trapping; museum pests; IPM; Austria

Online: 10 May 2024 (18:23:39 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202405.0663.v1

Transmission Lines in Modern Communication Systems: A Systematic Review

Mika Allyana Briones, Anajasnie Shamei Fung, Edwin Arboleda

Subject: Telecommunications, Engineering Keywords: Transmission Lines; Modern Communication; Communication Systems; Optical Fiber; Coaxial Cables; Microstrip

Online: 10 May 2024 (18:22:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0879.v2

Comparing the Efficacy of Manual Therapy and Exercise to Synchronized Telerehabilitation with Self-Manual Therapy and Exercise in Treating Subacromial Pain Syndrome: A Randomized Controlled Trial

Erman Berk Çelik, Ayşenur Tuncer

Subject: Physical Therapy, Sports Therapy And Rehabilitation, Public Health And Healthcare Keywords: subacromial pain syndrome; telerehabilitation; manual therapy

Online: 10 May 2024 (18:20:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0718.v1

Nitrogen-enriched Carbon Nanotube Supported Palladium as a Catalyst for Desulfurization of Dibenzothiophene and Reduction of Nitroarenes

José M. Sansano, Mohammad Gholinejad, Zeynab Elkhani, Sara Nayeri

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: Carbon nanotubes; functionalization; epoxides; ionic liquid, pollutant elimination; catalysis

Online: 10 May 2024 (16:59:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0709.v1

Potential Impact of Metabolic Syndrome Control on Cardiovascular Risk in Elderly Patients with Diabetes: A Cross-Sectional Study

Tânia Nascimento, Margarida Espírito-Santo, Adriana Gonçalves, Ezequiel Pinto, Ana Luísa De Sousa-Coelho, Maria Dulce Estêvão

Subject: Pharmacy, Medicine And Pharmacology Keywords: cardiovascular risk; ADVANCE risk score calculator; metabolic syndrome; type 2 diabetes mellitus; elderly

Online: 10 May 2024 (16:57:48 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0715.v1

Beyond 5G: A Comprehensive Exploration of 6G Wireless Communication Technologies

Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md Shahriar Uzzal

Subject: Telecommunications, Engineering Keywords: 6G wireless communication; Terahertz (THz) waves; Optical wireless technology; Dynamic spectrum management; Non-IP-based networking protocols; Cyber-security; Quantum communications; Artificial Intelligence (AI); Network architecture; Spectrum efficiency; Energy consumption; Reconfigurable intelligent surfaces; Holographic communication; Blockchain technology; Tactile internet

Online: 10 May 2024 (16:57:05 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0699.v1

Examining the Correlations between the Visceral Adiposity Index and Various Anthropometric, Biochemical, and Insulin Resistance Parameters in Brazilians: Findings from a Cross-Sectional Study

Lucas Fornari Laurindo, Francine Cruz Camargo, Alessandra Perfeito, Bruno Benedito Ciano, Clara Tainá Coelho, Gleice Assis Apolinário, Isabela Do Nascimento Vicentin, Jéssica Cambui Andreasi), Beatriz Leme Boaro, Ricardo José Tofano, Claudia Rucco P. Detregiachi, Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Lance Alan Sloan, Katia Portero Sloan, Antonelly Cassio Alves de Carvalho, Marie . Oshiiwa, Patrícia Cincotto dos Santos Bueno, Tereza Laís Menegucci Zutin, Marcelo Bechara, Karina Quesada

Subject: Primary Health Care, Public Health And Healthcare Keywords: Insulin Resistance; Visceral Adiposity Index; Cardiovascular Diseases; Cardiovascular Risk; Waist Circumference; Brazilian Population

Online: 10 May 2024 (16:56:40 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0691.v1

CTA Imaging of Peripheral Arterial Injuries

Stefania Tamburrini, Giulia Lassandro, Francesco Tiralongo, Francesca Iacobellis, Francesco Ronza, Carlo Liguori, Rosita Comune, Filomena Pezzullo, Michele Galluzzo, Salvatore Masala, Vincenza Granata, Antonio Basile, Mariano Scaglione

Subject: Emergency Medicine, Medicine And Pharmacology Keywords: peripheral arterial injuries; CTA; CT Angiography; vascular trauma; blunt trauma; penetrating trauma; dissection; transection; pseudoaneurysm

Online: 10 May 2024 (16:55:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0713.v1

Clustering Coefficient of Lexicographic Products

Melissa Holly

Subject: Discrete Mathematics And Combinatorics, Computer Science And Mathematics Keywords: lexicographic graph product; clustering coefficient; average clustering coefficient

Online: 10 May 2024 (16:55:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0711.v1

Ensemble Deep Learning-Based Image Classification for Breast Cancer Subtype and Invasiveness Diagnosis from Whole Slide Image Histopathology

Aadhi Balasubramanian, Salah Mohammed Awad Al-Heejawi, Akarsh Singh, Anne Breggia, Bilal Ahmad, Robert Christman, Ryan Stephen T., Saeed Amal

Subject: Pathology And Pathobiology, Medicine And Pharmacology Keywords: Prostate Cancer Diagnosis; Ensemble Deep Learning; Image Processing; Foundation Models; Computer Vision; Digital Pathology; Artificial Intelligence

Online: 10 May 2024 (16:54:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0690.v1

Artificial Intelligence Integrated Energy Education Framework. A Holistic Approach

Adam Stecyk, Ireneusz Miciuła

Subject: Other, Business, Economics And Management Keywords: energy; education; artificial intelligence; sustainable development; Delphi; AHP

Online: 10 May 2024 (16:53:27 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0714.v1

Literature Review on Milimeter-Wave Antenna Array Designs for 5G Communication

Klyde Adriane Monares, Ian Rafael Ebones, Edwin Arboleda

Subject: Telecommunications, Engineering Keywords: MM-Wave; 5G; Antenna Design

Online: 10 May 2024 (16:53:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0716.v1

Solving Apollonius’ Problem through Relativity

Christiaan Mantz

Subject: Theoretical Physics, Physical Sciences Keywords: Apollonius’ problem; conics; Relativity; foci; Lorentz transformation; frame of simultaneity

Online: 10 May 2024 (16:52:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0710.v1

Classification Of Strawberry Diseases and Quality Using Different Machine Learning Methods

Kimia Aghamohammadesmaeiletabforoosh, Soodeh Nikan, Giorgio Antonini, Joshua Pearce

Subject: Computer Vision And Graphics, Computer Science And Mathematics Keywords: computer vision; monitoring; strawberries; yield monitoring; image classification; machine learning; Vision Transformers; MobileNetV2; ResNet18

Online: 10 May 2024 (16:51:08 CEST)

Show abstract| Download PDF| Share

Machine learning and computer vision have proven to be valuable tools for farmers to streamline their resource utilization to lead to more sustainable and efficient agricultural production. These techniques have been applied to strawberry cultivation in the past with limited success. To build on this past work, in this study two separate sets of strawberry images, along with their associated diseases, were collected and subjected to, resizing, and augmentation. Subsequently, a combined dataset consisting of 9 classes was utilized to fine-tune three distinct pre-trained models: Vision Transformer (ViT), MobileNetV2, and ResNet18. To address the imbalanced class distribution in the dataset, each class was assigned weights to ensure nearly equal impact during the training process. To enhance the outcomes, new images were generated by removing backgrounds, reducing noise, and flipping them. The performances of ViT, MobileNetV2, and ResNet18 were compared after being selected. Customization specific to the task was applied to all three algorithms, and their performances were assessed. Throughout this experiment, none of the layers were frozen, ensuring all layers remained active during training. Attention heads were incorporated into the first 5 and last 5 layers of MobileNetV2 and ResNet18, while the architecture of ViT was modified. The results indicated accuracy factors of 98.4%, 98.1%, and 97.9% for ViT, MobileNetV2, and ResNet18, respectively. Despite the data being imbalanced, the precision, which indicates the proportion of correctly identified positive instances among all predicted positive instances, approached nearly 99% with the ViT. MobileNetV2 and ResNet18 demonstrated similar results. Overall, the analysis revealed that the Vision Transformer model exhibited superior performance in strawberry ripeness and disease classification. The inclusion of attention heads in the early layers of ResNet18 and MobileNet18, along with the inherent attention mechanism in ViT, improved the accuracy of image identification. These findings offer the potential for farmers to enhance strawberry cultivation through passive camera monitoring alone, promoting the health and well-being of the population.

Preprint ARTICLE | doi:10.20944/preprints202405.0712.v1

Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster

Xin Duan, Hao Lin Wang, Zhi Xian Cao, Na Su, Yu feng Wang, Ya Zheng

Subject: Insect Science, Biology And Life Sciences Keywords: ValRS-m；; Drosophila melanogaster；; mitochondria；; spermatogenesis；; meiosis

Online: 10 May 2024 (15:03:46 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0689.v1

Robust Trajectory Planning Of Gliding-Guided Projectiles With Weak Maneuverability

Qiulin Yin, Qi Chen, Zhongyuan Wang, Qinghai Wang

Subject: Control And Systems Engineering, Engineering Keywords: gliding-guided projectile; uncertainty; robust planning; trajectory tracking guidance; closed-loop feedback

Online: 10 May 2024 (14:33:37 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0704.v1

Live and Pasteurized Akkermansia muciniphila Mechanisms of Action and Its Potential Use as an Aid in the Treatment of Non-communicable Diseases

Honorata Mruk-Mazurkiewicz, Monika Kulaszyńska, Wiktoria Czarnecka, Albert Podkówka, Natalia Ekstedt, Piotr Zawodny, Anna Wierzbicka-Woś, Wojciech Marlicz, Błażej Skupin, Ewa Stachowska, Igor Łoniewski, Karolina Skonieczna-Żydecka

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: postbiotic; novel food; microbiota

Online: 10 May 2024 (14:22:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0706.v1

Dynamics between Classical Mechanics and Relativistic Insights

Soumendra Nath Thakur

Subject: Theoretical Physics, Physical Sciences Keywords: classical mechanics; relativistic dynamics; force-mass relationship; kinetic energy; effective mass; worke-nergy theorem

Online: 10 May 2024 (14:20:39 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202405.0700.v1

Assessing Sustainability In Supply Chain At Ethiopian Airlines (Cargo Wing): Strategies, Practices, And Areas For Improvement.

Samuel Aboagye

Subject: Business And Management, Business, Economics And Management Keywords: Sustainability; Airlines; supply chain; Aviation; Air quality; clean energy

Online: 10 May 2024 (14:19:25 CEST)

Show abstract| Download PDF| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202405.0703.v1

HUGENICS

Shahanas Naisam, Gayathri S S, Nidhin Sreekumar

Subject: Life Sciences, Biology And Life Sciences Keywords: Human Protein, Microbial protein, Disease Pathways, Human-Microbial Interaction.

Online: 10 May 2024 (14:17:51 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0701.v1

Recent Advances of 5G Technology Based on Patch Antenna: A Literature Review

Rhen John Rey Sacala, Edwin Arboleda

Subject: Telecommunications, Engineering Keywords: Patch Antennas; Substrate; MIMO; Antennas; 5G

Online: 10 May 2024 (14:16:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0698.v1

A Comparative Study of Susceptibility and Hazard for Mass Movements Applying Quantitative Machine Learning Techniques. Case Study: Northern Lima Commonwealth, Peru

Edwin Noe Badillo-Rivera, Manuel Daniel Olcese Huerta, Ramiro Santiago Chirinos, Teófilo Ivan Poma Inche, Neftalí Euclides Muñoz Fernandez, Carlos Alberto Rojas-León, Teodosio Juan Chávez Campos, Luz de Fátima Eyzaguirre Gorvenia, César Augusto Rodriguez Aburto, Fernando José Oyanguren Ramírez

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: mass movement, weight evidence, principal component analysis, machine learning.

Online: 10 May 2024 (14:15:59 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0684.v2

How Adversarial Rem-Dreams May Facilitate Creativity, and Why We Become Aware of Them

Nicolas Deperrois, Mihai A. Petrovici, Jakob Jordan, Lukas S. Huber, Walter Senn

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: rapid-eye-movement; sleep; learning

Online: 10 May 2024 (13:24:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0618.v1

Automatic Double Check Monitoring of Continuous Fluid Excretion and Urine Output

Nicolas Goy, Philippe Beuret, Alexandre Despond, Reza Porouchani, Jean-Jacques Goy

Subject: Urology And Nephrology, Medicine And Pharmacology Keywords: urine output; intensive care unit; monitoring; renal function

Online: 10 May 2024 (13:23:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0224.v2

A Longitudinal Study on Fingerprint Recognition in Infants, Toddlers, and Children

Mst Rumana Sumi, Masudul Imtiaz, Stephanie Schuckers

Subject: Electrical And Electronic Engineering, Engineering Keywords: fingerprint recognition; biometric identification; infant; child biometrics

Online: 10 May 2024 (13:21:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0619.v1

Evaluating Public Library Services Through User-Generated Content: Social Network Analysis of Google Maps Reviews

Chao-Chen Chen, Chen-Chi Chang

Subject: Library And Information Sciences, Social Sciences Keywords: user-generated content; public library evaluation; experiential feedback; service quality; Google Maps review

Online: 10 May 2024 (13:20:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0631.v1

Ultrasound B-mode Visualization of Imperceptible Subwavelength Vibration in Magnetomotive Ultrasound Imaging

Wei-Hsiang Shen, Tzu-Min Yeh, Mei-Yi Liao, Meng-Lin Li

Subject: Bioengineering, Engineering Keywords: motion magnification; ultrasound imaging; magnetomotive ultrasound; shear wave propagation

Online: 10 May 2024 (13:09:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0677.v1

A Bibliometric Review of the Trends of Construction Digitalization Research in the Last Decade

Simon O. Ametepey, Clinton Aigbavboa, Wellington Didibhuku Thwala, Hutton Addy

Subject: Architecture, Building And Construction, Engineering Keywords: Construction Digitalization, Bibliometric Analysis, VOS Viewer, Building Information Modeling, Automation, Blockchain, Smart Contracts.

Online: 10 May 2024 (12:26:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0683.v1

Impact of Antecedent Soil Moisture on Interrill Erosion

Yu-Da Chen, Chia-Chun Wu

Subject: Geography, Environmental And Earth Sciences Keywords: Interrill erosion, Soil loss, Antecedent soil moisture content, Rainfall Characteristics

Online: 10 May 2024 (12:23:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0694.v1

Preparation of quick-dissolving nanofibre face masks based on Needleless Electrostatic spinning

Jingyi Hu, Xiaojie Chen, Jianmin Jiang, Renbiao Mai, Han Wang, Qiming Xu, Ting Zhang

Subject: Chemical Engineering, Engineering Keywords: needleless; facial mask; electrospinning; nanofiber

Online: 10 May 2024 (12:22:24 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0651.v1

Emergence Of Antibiotic Residues And Antibiotic-resistant Bacteria In Hospital Wastewater: A Potential Dissemination Pathway Into The Environment: A Review

Wilfried Blandin EVOUNG CHANDJA, Richard Onanga, Pierre Philippe Mbehang Nguema, Romeo Wenceslas LENDAMBA, Yann MOUANGA-NDZIME, Jacques François MAVOUNGOU, Sylvain GODREUIL

Subject: Waste Management And Disposal, Environmental And Earth Sciences Keywords: hospital effluents; antibiotic resistance; bacteria; environment.

Online: 10 May 2024 (12:19:14 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0646.v1

Comparison of Small Blood Vessels Diameter with Intravascular Ultrasound and Coronary Angiography for Guidance of Percutaneous Coronary Intervention

Sergio Adrián Zuñiga-Mendoza, Emanuel Zayas-Diaz, Victoria del Rosario Armenta-Velazquez, Ana Aurora Silva-Baeza, Juan Jorge Beltran-Ochoa, Misael A. Medina-Servin, Maria G. Zavala-Cerna

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Cardiovascular disease; coronary artery disease; Percutaneous coronary intervention; Coronary angiography; Intravascular ultrasound; small vessel coronary artery disease.

Online: 10 May 2024 (12:17:54 CEST)

Show abstract| Download PDF| Share

Major cardiovascular events (MACE) are a cause of major mortality worldwide. The narrowing and blockage of coronary arteries with atherosclerotic plaques is diagnosed and treated with percutaneous coronary intervention (PCI). During this procedure, coronary angiography (CAG) remains the most widely used guidance modality for the evaluation the affected blood vessel diameter in order to decide if intervention with stent colocation is suitable, where small blood vessels (< 2.75 mm) are majorly left untreated; however, small vessel coronary artery disease (SvCAD) is a significant risk factor for recurrence of MACE, and there are some limitations to the use of CAG that could be improved with the use of newer techniques such as intravascular ultrasound (IVUS), although at higher costs, which might explain their underuse. To address this discrepancy and identify specific cases for its use, we conducted a retrospective study in patients who underwent PCI for MACE with at least one small blood vessel affected. The affected small blood vessels’ diameter was obtained with both CAG and IVUS, additionally we underwent a multivariate analysis to identify risk factors associated with a change in diameter. We included information from 48 patients with mean + SD age of 69.1 + 11.9 years and 34% were masculine gender. We found a significant positive low correlation in diameter measurements of small blood vessels (r=0.1242 p=0.014). Mean diameter with CAG and IVUS was 2.1 mm (95% CI 1.9-2.2), and 2.8 (2.8-3.0) the estimated difference was of 0.8 mm (95 % CI 0.7-0.9). In total 37 (77%) of patients had a reclassification of their blood vessels from a small to medium (2.75-3.00 mm) in 21 cases, or even large (<3.00 mm) in 15 cases, after IVUS; this was important for the decision of intervention and stent collocation. The only variable associated with reclassification of blood vessels after adjusted in a multivariate analysis was DT2 (p=0 0.035). Our findings corroborate that blood vessels might appear smaller with CAG, especially in the diabetes population, therefore at least in these cases the use of IVUS is recommended over CAG.

Preprint ARTICLE | doi:10.20944/preprints202405.0648.v1

Volatile Organic Compounds (VOCs) in Mediterranean Oak Forests of Hungarian Oak (Quercus frainetto Ten) Affected by Dieback Phenomena

Marisabel Mecca, Luigi Todaro, Maurizio D’Auria, Santain Settimio Pino Italiano, Adriano Sofo, Francesco Ripullone

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: climate change; drought; forest dieback; Hungarian oak; growth ring; SPME; VOC

Online: 10 May 2024 (12:16:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0642.v1

Fused Filament Fabrication of WC-10Co Hardmetals: A Study on Binder Formulations, and printing variables.

Julián David Rubiano Buitrago, Andrés Fernando Gil Plazas, Luis Alejandro Boyacá Mendivelso, Liz Karen Herrera Quintero

Subject: Metallurgy And Metallurgical Engineering, Engineering Keywords: Hardmetals; Fused Filament Fabrication; Additive Manufacturing; Feedstock Formulation; Printing Force Measurement.

Online: 10 May 2024 (12:14:50 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0637.v1

Biological Response of Erythrocytes to Laser Irradiation with a Wavelength of 445 nm (An Experimental Study)

Natalia Valerievna Romanenko, Natalia Borisovna Serezhnikova, Albert Artemovich Davtyan, Svetlana Victorovna Tarasenko, Sofiko Valerianovna Djidjavadze, Alexander Alexandrovich Derevyankin, Ekaterina Viacheslavovna Shchetinina, Viktoriya Evgen'evna Arifdzhanova, Alexander Sadykovich Sadykov, Tatyana Leonidovna Polyakova

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: blue laser; erythrocytes; red blood cells; low level laser irradiation; low level laser therapy; laser irradiation with a wavelength of 445 nm; periodontal disease

Online: 10 May 2024 (12:13:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0658.v1

The Androgen Dehydroepiandrosterone Sulfate Shows a Greater Relationship with Impulsivity than Testosterone in a Male Healthy Sample

Anton Aluja, Ferran Balada, Óscar García, Neus Aymamí, Luis F García

Subject: Behavioral Sciences, Biology And Life Sciences Keywords: Impulsivity personality trait; Dehydroepiandrosterone Sulfate (DHEA-S); testosterone; BIS-11; UPPS-P

Online: 10 May 2024 (11:55:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0655.v1

Sustainable and Innovative Self-Healing Concrete Technologies to Mitigate Environmental Impacts in Construction

Vinayak Kaushal, Elayna Saeed

Subject: Civil Engineering, Engineering Keywords: Self-healing concrete; sustainable technologies; construction; environmental impacts; carbon footprints

Online: 10 May 2024 (11:54:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0659.v1

Facial Pain Expression Detection System using TXQEDA-Deep for Pain Evaluation

Rachid Aliradi, Nidhaleddine Chenni, Mohammed Touami, Ridha Ejbali, Najib Benaoun

Subject: Computer Science, Computer Science And Mathematics Keywords: Accuracy; Pain Assessment; PSPI; SVC; SVM; Multilinear subspace learning; TXQEDA; CNN-Deep Learning; UNBC McMaster dataset

Online: 10 May 2024 (11:52:37 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202405.0670.v1

Band Gap Formation and Semiconducting Properties of Graphene Adsorbed by Metal Oxide

Chang-Soo Park, Younghae Kwon, Heetae Kim, Deuk Young Kim

Subject: Applied Physics, Physical Sciences Keywords: Graphene; Band gap; Chemical vapor deposition; Transistor; Metal-oxide

Online: 10 May 2024 (11:51:35 CEST)

Show abstract| Download PDF| Share

Preprint ESSAY | doi:10.20944/preprints202405.0650.v1

After the Greenfire Revolution: Reimagining Collective Identities of the Future Wildland Fire Workforce in a Paradigm Shift for Ecological Fire Management

Timothy Ingalsbee

Subject: Sociology, Social Sciences Keywords: new social movement theory; collective identity; wildland fire management; paradigm shift

Online: 10 May 2024 (11:50:27 CEST)

Show abstract| Download PDF| Share

Preprint HYPOTHESIS | doi:10.20944/preprints202404.1631.v3

Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery

Michael Renteln

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: bacterial capsule; caged luciferin/luciferase; CY3PA; light-activated allosteric protein switch; Deadman switch; bactofection

Online: 10 May 2024 (11:49:27 CEST)

Show abstract| Download PDF| Share

Search Results

60841 articles found