Version 1
: Received: 6 December 2023 / Approved: 12 December 2023 / Online: 12 December 2023 (11:15:21 CET)
How to cite:
Clemens, Z.; Dabóczi, A.; Andrásofszky, E.; Schimmer, M.; Daniels, N.; Szathmári, O.; Fésüs, E.; Horváth, R. The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects. Preprints2023, 2023120817. https://doi.org/10.20944/preprints202312.0817.v1
Clemens, Z.; Dabóczi, A.; Andrásofszky, E.; Schimmer, M.; Daniels, N.; Szathmári, O.; Fésüs, E.; Horváth, R. The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects. Preprints 2023, 2023120817. https://doi.org/10.20944/preprints202312.0817.v1
Clemens, Z.; Dabóczi, A.; Andrásofszky, E.; Schimmer, M.; Daniels, N.; Szathmári, O.; Fésüs, E.; Horváth, R. The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects. Preprints2023, 2023120817. https://doi.org/10.20944/preprints202312.0817.v1
APA Style
Clemens, Z., Dabóczi, A., Andrásofszky, E., Schimmer, M., Daniels, N., Szathmári, O., Fésüs, E., & Horváth, R. (2023). The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects. Preprints. https://doi.org/10.20944/preprints202312.0817.v1
Chicago/Turabian Style
Clemens, Z., Erika Fésüs and Réka Horváth. 2023 "The Paleolithic Ketogenic Diet (PKD) Is Associated with Low C-peptide Levels in Non-T1DM Patients and Healthy Subjects" Preprints. https://doi.org/10.20944/preprints202312.0817.v1
Abstract
C-peptide is used as a measure of endogenous insulin production. Given that insulin and C-peptide are produced in equal amounts, C-peptide is typically used to differentiate between external and endogenously produced insulin in insulin-treated type 1 diabetes mellitus (T1DM). In a clinical setting, a decline in C-peptide is regarded as a loss of beta cell function. However, physiological conditions may also be associated with low C-peptide levels. The authors of this paper use a low-carbohydrate diet, the so-called paleolithic ketogenic diet (PKD), in the treatment of various conditions and observed that C-peptide is typically low on this diet. In order to characterize C-peptide levels on this diet, we designed a study to retrospectively assess C-peptide levels in 100 non-T1DM subjects. We found that 55% of the subjects had a C-peptide level below the standard reference range. C-peptide levels correlated with glucose levels. A significant correlation was found between C-peptide and age, with younger subjects having lower C-peptide levels. Males also showed lower C-peptide levels than females. Given the increasing number of patients using low-carbohydrate diets worldwide, physicians should be aware of laboratory correlates of low-carbohydrate diets, including low C-peptide levels, most importantly to prevent incorrect T1DM diagnosis.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
