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D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV
Version 1
: Received: 20 July 2020 / Approved: 21 July 2020 / Online: 21 July 2020 (12:47:13 CEST)
How to cite:
Bassa, B.; Olen, B. D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV. Preprints2020, 2020070488. https://doi.org/10.20944/preprints202007.0488.v1
Bassa, B.; Olen, B. D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV. Preprints 2020, 2020070488. https://doi.org/10.20944/preprints202007.0488.v1
Bassa, B.; Olen, B. D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV. Preprints2020, 2020070488. https://doi.org/10.20944/preprints202007.0488.v1
APA Style
Bassa, B., & Olen, B. (2020). D614 Residue Belongs to a Highly Conserved Peptide Motif in <em>Sarbecovirus </em>Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV. Preprints. https://doi.org/10.20944/preprints202007.0488.v1
Chicago/Turabian Style
Bassa, B. and Brown Olen. 2020 "D614 Residue Belongs to a Highly Conserved Peptide Motif in <em>Sarbecovirus </em>Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV" Preprints. https://doi.org/10.20944/preprints202007.0488.v1
Abstract
Conservation history of D614 residue is valuable in predicting the consequences of D614G mutation in the SARS-CoV-2 spike glycoprotein (SGP). We report here that the D614 belonged to an extraordinarily conserved, densely hydrophobic eleven amino acid peptide-motif vavlyqdvnct(11-aa), in the Sarbecovirus group and the variant carrying vavlyqdvnct had appeared in Chinese samples and became predominant in several geographical hotspots in late March, 2020. Interestingly a 2009 annotation of SARS-CoV contained the same mutation.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
