Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV

Version 1 : Received: 20 July 2020 / Approved: 21 July 2020 / Online: 21 July 2020 (12:47:13 CEST)

How to cite: Bassa, B.; Olen, B. D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV. Preprints 2020, 2020070488 (doi: 10.20944/preprints202007.0488.v1). Bassa, B.; Olen, B. D614 Residue Belongs to a Highly Conserved Peptide Motif in Sarbecovirus Group and the D614G Mutation of SARS-CoV-2 Spike Protein Appeared Once in SARS-CoV. Preprints 2020, 2020070488 (doi: 10.20944/preprints202007.0488.v1).

Abstract

Conservation history of D614 residue is valuable in predicting the consequences of D614G mutation in the SARS-CoV-2 spike glycoprotein (SGP). We report here that the D614 belonged to an extraordinarily conserved, densely hydrophobic eleven amino acid peptide-motif vavlyqdvnct (11-aa), in the Sarbecovirus group and the variant carrying vavlyqdvnct had appeared in Chinese samples and became predominant in several geographical hotspots in late March, 2020. Interestingly a 2009 annotation of SARS-CoV contained the same mutation.

Subject Areas

SARS-CoV; SARS-CoV; COVID-19; Sarbecovirus; D614G; Spike glycoprotein; Coronavirus; Alignment-free

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