Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical vein Blood in Type-1 Diabetes

Josip Delmis
* ORCID logo ,
Slavko Oreskovic
,
Vesna Elvedji Gasparovic
,
Mirta Starcevic
,
Mislav Herman
,
Nada Dessardo
,
Vito Starcevic
,
Marina Ivanisevic
ORCID logo
Version 1 : Received: 7 January 2023 / Approved: 11 January 2023 / Online: 11 January 2023 (02:57:33 CET)

A peer-reviewed article of this Preprint also exists.

Delmis, J.; Oreskovic, S.; Elvedji Gasparovic, V.; Starcevic, M.; Herman, M.; Dessardo, N.; Starcevic, V.; Ivanisevic, M. Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes. Nutrients 2023, 15, 600. Delmis, J.; Oreskovic, S.; Elvedji Gasparovic, V.; Starcevic, M.; Herman, M.; Dessardo, N.; Starcevic, V.; Ivanisevic, M. Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes. Nutrients 2023, 15, 600.

Abstract

The study aimed to determine the relationship between glucose, C-peptide, BDNF, and leptin between mother and fetus and neonatal weight. Methods: In the prospective observational cohort study, we included 66 women with T1DM. According to the z-score for neonatal weight, patients were divided into Healthy weight neonates (n=42) and Overweight neonates (n=24). The maternal blood samples were taken during pregnancy and cesarean section when the umbilical vein blood sample was also withdrawn. The maternal vein sera were analyzed for fasting glucose, CRP, leptin, BDNF, TSH, FT3, and FT4. The umbilical vein sera were analyzed for glucose, C-peptide, leptin, TSH, FT3, FT4, and BDNF concentration. The neonatologist measured the skinfold thickness on the third day of neonatal life. Results: A strong correlation was confirmed between maternal and umbilical vein glucose concentration and maternal glucose and C-peptide in umbilical vein blood. A negative correlation was found between the concentration of BDNF in the umbilical vein and glucose in maternal blood. A strong correlation was seen between BMI and maternal blood leptin concentration, neonatal fat body mass, and umbilical vein blood leptin concentration. Increased odds for Overweight neonates were BMI, BDNF, and TSH in the first trimester of pregnancy. Maternal leptin concentration decreased the odds of Overweight neonates. Conclusions: Maternal glucose concentrations affect the fetus’s glucose, C-peptide, and BDNF concentrations. Leptin levels increase in maternal blood due to increased body mass index, and in the neonate, its fat body mass is responsible for increased leptin concentrations.

Keywords

BDNF; CRP; C-peptide; leptin; pregnancy; skinfold thickness; thyroid hormones; type-1 diabetes mellitus

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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