Solid Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond

Krzysztof Kaczmarek; Barbara Pacholczyk-Sienicka; Łukasz Albrecht; Janusz Zabrocki; Ronald Nachman

doi:10.20944/preprints202104.0518.v1

How to cite: Kaczmarek, K.; Pacholczyk-Sienicka, B.; Albrecht, Ł.; Zabrocki, J.; Nachman, R. Solid Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond. Preprints 2021, 2021040518. https://doi.org/10.20944/preprints202104.0518.v1. Kaczmarek, K.; Pacholczyk-Sienicka, B.; Albrecht, Ł.; Zabrocki, J.; Nachman, R. Solid Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond. Preprints 2021, 2021040518. https://doi.org/10.20944/preprints202104.0518.v1.

Abstract

A facile solid-phase synthetic method for incorporating the imidazoline ring motif, a surrogate for a trans peptide bond, into bioactive peptides is reported. The example described is the synthesis of an imidazoline peptidomimetic analog of an insect pyrokinin neuropeptide via a cyclization reaction of an iminium salt generated from the preceding amino acid and 2,4-diaminopropanoic acid (Dap).

Keywords

Subject

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Solid Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond

Abstract

Keywords

Subject

Comments (0)