Lemus-Conejo, A.; Grao-Cruces, E.; Toscano, R.; Varela, L.M.; Claro, C.; Pedroche, J.; Millan, F.; Millan-Linares, M.C.; Montserrat-de la Paz, S. Lupine (Lupinus angustifolius L.) Peptide Prevents Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice. Preprints2019, 2019070180. https://doi.org/10.20944/preprints201907.0180.v1
Lemus-Conejo, A., Grao-Cruces, E., Toscano, R., Varela, L.M., Claro, C., Pedroche, J., Millan, F., Millan-Linares, M.C., & Montserrat-de la Paz, S. (2019). Lupine (<em>Lupinus angustifolius</em> L.) Peptide Prevents Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice. Preprints. https://doi.org/10.20944/preprints201907.0180.v1
Lemus-Conejo, A., Maria C Millan-Linares and Sergio Montserrat-de la Paz. 2019 "Lupine (<em>Lupinus angustifolius</em> L.) Peptide Prevents Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice" Preprints. https://doi.org/10.20944/preprints201907.0180.v1
Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide which was isolated from lupine (Lupinus angustifolius L.) and showed anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or an HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in their drinking water at 0,5 mg/kg/d or 1 mg/kg/d. To determine the ability of GPETAFLR to improve the onset and progression of NAFLD, histological studies, hepatic enzyme profile, inflammatory cytokine and lipid metabolism-related genes and proteins were analyzed. Our results suggest that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption could repair HFD-induced hepatic damage, possibly via modifications in the liver’s lipid signalling pathways.
GPETAFLR peptide; protein hydrolysate; liver; hepatic steatosis; high-fat diet
Biology and Life Sciences, Endocrinology and Metabolism
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