Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

Ming Bi; Hui Han; Shujun Dong; Ying Zhang; Weiguo Xu; Bitao Zhu; Jingyun Wang; Yanmin Zhou; Jianxun Ding

doi:10.20944/preprints201801.0149.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints201801.0149.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

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Version 1 : Received: 16 January 2018 / Approved: 17 January 2018 / Online: 17 January 2018 (06:48:17 CET)

A peer-reviewed article of this Preprint also exists.

Bi, M.; Han, H.; Dong, S.; Zhang, Y.; Xu, W.; Zhu, B.; Wang, J.; Zhou, Y.; Ding, J. Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect. Polymers 2018, 10, 109. Bi, M.; Han, H.; Dong, S.; Zhang, Y.; Xu, W.; Zhu, B.; Wang, J.; Zhou, Y.; Ding, J. Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect. Polymers 2018, 10, 109.

Abstract

The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design.

Keywords

porous scaffold; collagen coating; bioactive peptide; skull defect repair; tissue engineering

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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