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Preprint ARTICLE | doi:10.20944/preprints201902.0064.v1

A Complete Assessment of Dopamine Receptor-Ligand Interactions through Computational Methods

Beatriz Bueschbell, Carlos A.V. Barreto, Antonio J. Preto, Anke C. Schiedel, Irina S. Moreira

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Dopamine receptors, Molecular Docking, Molecular Dynamics, Receptor-Ligand Interactions

Online: 6 February 2019 (13:54:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0020.v2

Magnetic Engine for the Single-Particle Landau Problem

Francisco J. Peña, Alejandro González, A.S. Nunez, Pedro A. Orellana, René G. Rojas, P. Vargas

Subject: Physical Sciences, Condensed Matter Physics Keywords: quantum thermodynamics; degeneracy effects; magnetic quantum engine

Online: 8 November 2017 (16:56:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0047.v1

Artificial Intelligence and Military Applications: Innovations, Cybersecurity Challenges & Open Research Areas

Priyanka Jayakumar, Sarfraz Nawaz Brohi, Noor Zaman Jhanjhi

Subject: Computer Science And Mathematics, Security Systems Keywords: Artificial Intelligence; Military technology; Robotic and Autonomous systems; Autonomous weapons systems

Online: 2 August 2021 (14:33:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0305.v1

The Zeros of the Dirichlet Beta Function Encode the Odd Primes and Have Real Part 1/2

Anthony Lander

Subject: Computer Science And Mathematics, Mathematics Keywords: Catalan beta function; Riemann’s zeta function; primes; Dirichlet L-function

Online: 24 April 2018 (05:10:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0607.v2

Gravitational-Magnetic-Electric Interaction in Controlling Relative Permittivity and Permeability

Yin Zhu

Subject: Physical Sciences, Particle And Field Physics Keywords: Gravitational-electric-magnetic interaction; Controlling permittivity and permeability; Superconductivity

Online: 13 September 2021 (12:31:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0324.v4

From Information and Quantum Physics to Consciousness and Reality

Peter Verheyen

Subject: Physical Sciences, Quantum Science And Technology Keywords: Information; Quantum Physics; Biochemical Projection; Neural Interpretation; Consciousness; Reality

Online: 25 August 2021 (11:24:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0115.v1

The Future of Cybersecurity with Artificial Intelligence (AI) and Machine Learning (ML)

Hrishitva Patel

Subject: Computer Science And Mathematics, Security Systems Keywords: Artificial Intelligence (AI); Machine Learning (ML); Cyber security; Uses of Cyber security; Future in Cyber security; AI and ML in Cyber security

Online: 6 January 2023 (04:39:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0085.v1

Economic Driven Patterns of the Urban Environment

Anibal Gusso, Conrad Philipp, André Silva, John Boland, Leticia Lenz

Subject: Environmental And Earth Sciences, Environmental Science Keywords: thermal remote sensing; EKC theory; urban development

Online: 16 December 2016 (08:00:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0428.v1

Dynamical Feedback Control: Motor Cortex as an Optimal Feedback Controller Based on Neural Dynamics

Christopher Versteeg, Lee Miller

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Motor Control; Feedback; Dynamical Systems

Online: 28 January 2022 (08:03:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0052.v1

Beneficial Effects of Pyridoxal Phosphate on Hydrogen Peroxide Induced Stress on Isolated Pancreatic Acinar Cells

Rajanna Ajumeera, Vijayalakshmi Venkatesan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: acinar cells; PLP; amylase; insulin secretion; FACS; viability; PDX-1

Online: 5 August 2016 (08:49:33 CEST)

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Aims: To study the effects of pyridoxal phosphate (PLP) on oxidative stress in isolated pancreatic acinar cells. We have previously shown that PLP has cytoprotective and insulinotropic effects on mice islet cells in vivo and in vitro studies. Main methods: Acinar cells were isolated from three months old WNIN male rats and were cultured in vitro for a period of 24 h in CO₂ incubator. Later the cells were divided into four groups as untreated (group 1), H₂O₂treatment (group 2)_,PLP treatment (group 3) and PLP followed by H₂O₂ treatment (group 4). Cell viability was confirmed using MTT assays, oxidative stress levels were measured with ROS assay, change in different protein levels were recorded by flow cytometry. The acinar cells insulin secretion assay was performed with ELISA. The amylase protein expression was assessed using confocal microscopy. Key findings: The cell viability of acinar cell in group 1 was considered as 100%, while in group 2 it was reduced to 82% due to H₂O₂effect, and in group 3 (99.8%) and group 4 (99.5%) were near to group 1 due to the cytoprotective effect of PLP. The ROS levels were increased by 1.47 folds in group 2, while PLP decreased to 1.02 fold in group 4, which was comparable with the changes in group 1. Beneficial effects of PLP were also observed from the increased expression levels of acinar cells are amylase -2.01, neurogenin-3-9.51, PDX-1- 23.6 and insulin-13.5 in group 3 compared to group 1. The specificity of PLP’s response was confirmed by amino oxy acetic acid (AOAA), a specific PLP inhibitor. The increased amylase protein localization with PLP was confirmed by confocal microscopy. Insulin secretion efficiency of acinar cells was observed to be 6.13 folds higher at basal and 24.63 fold higher at stimulated levels in group3 compared to group1. Significance: Our results advocate the antioxidant and cytoprotective effects of PLP on the pancreatic acinar cell along with increased pancreatic marker expressions of amylase,PDX-1, neurogenin-3 and insulin proteins.

Preprint REVIEW | doi:10.20944/preprints202102.0033.v1

CRISPR/dCas9-based Systems: Mechanisms and Applications in Plant Sciences

Chou Khai Soong Karlson, Siti Nurfadhlina Mohd Noor, Nadja Nolte, Boon Chin Tan

Subject: Biology And Life Sciences, Plant Sciences Keywords: CRISPR interference; CRISPR/dCas9 system; crop improvement; gene silencing; RNAi; transcriptional regulation

Online: 1 February 2021 (13:31:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0425.v1

Periorbital Hyperpigmentation, a Dermatologic Condition Having a Strong Geographic and Ethnic Determinism

Felicia Andrei, Daciana Grujic, Cristina Lazar, Anca Dragomirescu

Subject: Medicine And Pharmacology, Dermatology Keywords: hyperpigmentation; palpebral region; geographic skin differences; ethnic predisposition; skin disorder;

Online: 23 July 2018 (12:56:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0002.v2

Small UAS-Based Wind Feature Identification System Part 1: Integration and Validation

Leopoldo Rodriguez Salazar, Jose A. Cobano, Anibal Ollero

Subject: Engineering, Control And Systems Engineering Keywords: wind prediction; wind estimation; UAS; wind shear; gust; multi-platform integration

Online: 18 January 2017 (09:44:54 CET)

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This paper presents a system for identification of wind features, such as gusts and wind shear. These are of particular interest in the context of energy-efficient navigation of Small Unmanned Aerial Systems (UAS). The proposed system generates real-time wind vector estimates and a novel algorithm to generate wind field predictions. Estimations are based on the integration of an off-the-shelf navigation system and airspeed readings in a so-called direct approach. Wind predictions use atmospheric models to characterize the wind field with different statistical analyses. During the prediction stage, the system is able to incorporate, in a big-data approach, wind measurements from previous flights in order to enhance the approximations. Wind estimates are classified and fitted into a Weibull probability density function. A Genetic Algorithm (GA) is utilized to determine the shaping and scale parameters of the distribution, which are employed to determine the most probable wind speed at a certain position. The system uses this information to characterize a wind shear or a discrete gust and also utilizes a Gaussian Process regression to characterize continuous gusts. The knowledge of the wind features is crucial for computing energy-efficient trajectories with low cost and payload. Therefore, the system provides a solution that does not require any additional sensors. The system architecture presents a modular decentralized approach, in which the main parts of the system are separated in modules and the exchange of information is managed by a communication handler to enhance upgradeability and maintainability. Validation is done providing preliminary results of both simulations and Software-In-The-Loop testing. Telemetry data collected from real flights, performed in the Seville Metropolitan Area in Andalusia (Spain), was used for testing. Results show that wind estimation and predictions can be calculated at 1 Hz and a wind map can be updated at 0.4 Hz. Predictions show a convergence time with a 95% confidence interval of approximately 30 s.

Preprint ARTICLE | doi:10.20944/preprints201703.0080.v1

Detecting Breast Cancer with a Dual-Modality Device

Kamila Padia, Tania S. Douglas, Lydia L. Cairncross, Roland V. Baasch, Christopher L. Vaughan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; dense breasts; dual-modality imaging; FFDM; ABUS

Online: 14 March 2017 (09:24:58 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202005.0023.v1

First Record of Presence of the Invasive Land Flatworm Platydemus manokwari (Platyhelminthes, Geoplanidae) in Guadeloupe

Jean-Lou Justine, Leigh Winsor

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Invasive Alien Species; Guadeloupe; Geoplanidae; Platydemus manokwari; Citizen Science

Online: 2 May 2020 (16:44:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0127.v1

In-Vivo Acoustic Surveillance of Trees in the Context of IoT

Ilias Potamitis, Iraklis Rigakis, Nicolaos-Alexandros Tatlas, Stelios Potirakis

Subject: Engineering, Electrical And Electronic Engineering Keywords: Xylotrechus chinensis; Rhynchophorus ferrugineus; precision agriculture; IoT.

Online: 14 February 2019 (10:04:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0133.v1

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected from a Syndrome of Caudal Regression

Jesús Devesa, Alba Alonso, Natalia López, José García, Carlos Israel Puell, Tamara Pablos, Pablo Devesa

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: GH; syndrome of caudal regression; sacral agenesis; physiotherapy; neurogenic bladder; flaccid paraplegia

Online: 27 November 2016 (04:35:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0052.v1

Oral Mucositis: Melatonin Gel an Effective New Treatment

Ahmed E Abdel-Moneim, Ana Guerra-Librero, Javier Florido, Ying-Qiang Shen, Beatriz Fernández-Gil, Darío Acuña-Castroviejo, Germaine Escames

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin

Online: 9 March 2017 (04:46:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0085.v1

ITO-Free Transparent Organic Solar Cell with Distributed Bragg Reflector for Solar Harvesting Windows

Yuelin Peng, Lushuai Zhang, Nongyi Cheng, Trisha L. Andrew

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: transparent electrode; organic photovoltaic; distributed Bragg reflector

Online: 9 May 2017 (11:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0061.v1

Image-Based Multi-Target Tracking Through Multi-Bernoulli Filtering with Interactive Likelihoods

Anthony Hoak, Henry Medeiros, Richard J. Povinelli

Subject: Engineering, Electrical And Electronic Engineering Keywords: multi-target tracking; multi-Bernoulli filter; sequential Monte-Carlo

Online: 16 February 2017 (09:39:29 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201710.0098.v1

Assessing Error Correlations in Remote Sensing-Based Estimates of Forest Attributes for Improved Composite Estimation

Sarah Ehlers, Svetlana Saarela, Nils Lindgren, Eva Lindberg, Mattias Nyström, Henrik J. Persson, Håkan Olsson, Göran Ståhl

Subject: Environmental And Earth Sciences, Environmental Science Keywords: airborne LiDAR; composite estimators; forest inventory; SPOT-5 HRG; TanDEM-X

Online: 16 October 2017 (04:30:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0121.v1

Two Finite Mirror-Image Series Restrict the Non-Trivial Zeros of Riemann’s Zeta Function to Re(s) = 1/2 and the Zeros of its Derivative to Re(s) > 1/2

Anthony Lander

Subject: Computer Science And Mathematics, Mathematics Keywords: Riemann Hypothesis; Dirichlet eta function; Zeta function; prime numbers; number theory; critical-line; critical-strip; symmetry breaking

Online: 16 March 2017 (16:59:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0092.v1

Estimating Density and Temperature Dependence of Juvenile Vital Rates Using a Hidden Markov Model

Robert M. McElderry

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Anaea aidea; caterpillar demography; multi-state mark-recapture; state-space model; stage-structured matrix

Online: 18 December 2016 (09:33:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0500.v1

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Mohammad Mukarram, Sadaf Choudhary, Mo Ahamad Khan, Palmiro Poltronieri, M. Masroor A. Khan, Jamin Ali, Daniel Kurjak, Mohd Shahid

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: anticancer; antimicrobial; antioxidants; cancer signalling; citral; Cymbopogon; essential oil

Online: 21 June 2021 (10:31:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0085.v1

COVID-19: Multiple Diseases Simulating Extreme High-Altitude Exposure? Oxygen Transport Physiology and Scarce Need of Ventilators; Andean Condor’s-Eye-View

Gustavo R. Zubieta-Calleja, Natalia Zubieta-DeUrioste, Thuppil Venkatesh, Kusal Das, Jorge Soliz

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; HAPE; high-altitude; tolerance to hypoxia; oxygen transport triad; Cov-2; SARS; pneumonia; ventilators; EPO

Online: 5 May 2020 (15:26:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0207.v1

Chinese Guidelines Related to Novel Coronavirus Pneumonia

Tingting Qiu, Shuyao Liang, Monique Dabbous, Yitong Wang, Ru Han, Mondher Toumi

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Chinese Guidelines; COVID-19; pharmaceutical treatment

Online: 13 April 2020 (03:43:37 CEST)

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Background and Objective: China has managed to control the coronavirus disease (COVID-19) with confinement measurements and treatment strategies, while other countries are struggling to contain the spread. This study discusses the guidelines related to COVID-19 in China in order to provide important references for other countries in the fight against COVID-19. Methods: Chinese guidelines relevant to COVID-19 were systematically searched via the China National Knowledge Infrastructure database, YiMaiTong database, and World Health Organization (WHO) COVID-19 database on March 20^th, 2020. Guideline information was extracted, including date of publication, source, objectives and the target population. Guidelines specific to the pharmacological treatment of COVID-19 were further investigated to identify the types of antivirus drugs recommended and to report on how treatment recommendations for COVID-19 have evolved overtime. Results: A total of 114 guidelines were identified, of which 87 were national guidelines and 27 were regional guidelines. The scope of included guidelines consisted of: the diagnosis and treatment of COVID-19, the management of hospital departments and specific diseases during the outbreak of COVID-19. Sixty-four of the included guidelines targeted all COVID-19 patients, while the remaining guidelines concentrated on special patient populations (i.e., geriatric population, pediatric population, and pregnant population) or patients with coexisting diseases. Twenty-three guidelines focused on the pharmacological treatments for all COVID-19 patients. Interferon, Lopinavir/Ritonavir, Ribavirin, Chloroquine, and Umifenovir represented the most recommended antivirus drugs. With the emergence of encouraging results from preclinical and preliminary clinical studies, Chloroquine Phosphate was recommended in the national Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (6^th version) on February 19^th, 2020. Thereafter, more detailed guidelines regarding the adjustment of dosage regimens and the monitoring of adverse events of Chloroquine Phosphate were published. To date, 8 Chinese guidelines have recommended Chloroquine Phosphate or Hydroxychloroquine as mainstream antivirus drug for the treatment of COVID-19. Conclusions: China has generated a plethora of guidelines covering almost all aspects of COVID-19. Chloroquine, as one widely affordable treatment, holds great potential to become the gold standard choice as more clinical evidence is shared by researchers from China as well as other countries.

Preprint ARTICLE | doi:10.20944/preprints201703.0168.v1

Mechanical and Corrosion Behavior of Al-Zn-Cr Family Alloys

Ahmed Nassef, Waleed H. El-Garaihy, Medhat El-Hadek

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Al-Zn-Cr Alloys; powder metallurgy; strengthening; extrusion; dry sliding wear

Online: 21 March 2017 (04:26:13 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201704.0152.v1

Treatment of Intrusive Suicidal Imagery Using Eye Movements

Jael S Van Bentum, Marit Sijbrandij, Marcus Huibers, Annemiek Huisman, Arnoud Arntz, Emily Holmes, Ad Kerkhof

Subject: Social Sciences, Psychology Keywords: suicide; suicidal mental imagery; flash-forwards; intrusions; preventive intervention; eye movement dual task (EMDT)

Online: 24 April 2017 (11:59:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints201705.0125.v1

The European Insurance Industry: A PEST analysis

Charmaine Barbara, Dominic Cortis, Roberta Perotti, Claudia Sammut, Antoine Vella

Subject: Business, Economics And Management, Finance Keywords: Insurance; PEST; political; risks; challenges; economy; European Union

Online: 16 May 2017 (17:01:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0070.v1

Oxidation of Human Serum Albumin Exhibits Inter-Individual Variability after an Ultra-Marathon Mountain Race

Ypatios Spanidis, Alexandros Priftis, Dimitrios Stagos, George A. Stravodimos, Demetres D. Leonidas, Demetrios Kouretas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: albumin; oxidative stress; exercise; ultra-marathon mountain race; protein oxidation

Online: 17 February 2017 (15:02:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0093.v1

Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in Older Women Born from Normal Weight Mothers

Robert M. Badeau, Miikka-Juhani Honka, Marco Bucci, Patricia Iozzo, Johan G. Eriksson, Pirjo Nuutila

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: 22:6 docosahexaenoic acid; ω-3 fatty acids; offspring of obese mothers; offspring of lean mothers; insulin-dependent skeletal muscle glucose uptake

Online: 20 January 2017 (04:59:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0150.v1

Emergence of Standard-Model-Like Fields and Particles in Gravitation-Diffusion Vacuum

Vladimir A. Manasson

Subject: Physical Sciences, Particle And Field Physics Keywords: particle physics; unification of forces; self-organization; coupling constants; quark flavors; quark mixing amplitudes; quantum statistics; open systems; Feigenbaum universality; synchronization

Online: 8 October 2018 (14:29:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0188.v1

The Investigation of Electrochemistry Behaviors of Tyrosinase Based on Directly Electrodeposited Graphene on Choline–Gold Nanoparticals

Yaping He, Xiaohui Yang, Quan Han, Jianbin Zheng

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: electrochemistry; tyrosinase; graphene; Choline–gold nanoparticals; catechol

Online: 28 April 2017 (05:25:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0080.v1

MRST-Shale: An Open-Source Framework for Generic Numerical Modeling of Unconventional Shale and Tight Gas Reservoirs

Bin Wang

Subject: Engineering, Energy And Fuel Technology Keywords: shale gas; MRST; embedded discrete fracture model; open-source implementation

Online: 9 January 2020 (09:59:37 CET)

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We present a generic and open-source framework for the numerical modeling of the expected transport and storage mechanisms in unconventional gas reservoirs. These unconventional reservoirs typically contain natural fractures at multiple scales. Considering the importance of these fractures in shale gas production, we perform a rigorous study on the accuracy of different fracture models. The framework is validated against an industrial simulator and is used to perform a history-matching study on the Barnett shale. This work presents an open-source code that leverages cutting-edge numerical modeling capabilities like automatic differentiation, stochastic fracture modeling, multi-continuum modeling and other explicit and discrete fracture models. We modified the conventional mass balance equation to account for the physical mechanisms that are unique to organic-rich source rocks. Some of these include the use of an adsorption isotherm, a dynamic permeability-correction function, and an embedded discrete fracture model (EDFM) with fracture-well connectivity. We explore the accuracy of the EDFM for modeling hydraulically-fractured shale-gas wells, which could be connected to natural fractures of finite or infinite conductivity, and could deform during production. Simulation results indicates that although the EDFM provides a computationally efficient model for describing flow in natural and hydraulic fractures, it could be inaccurate under these three conditions: 1. when the fracture conductivity is very low. 2. when the fractures are not orthogonal to the underlying Cartesian grid blocks, and 3. when sharp pressure drops occur in large grid blocks with insufficient mesh refinement. Each of these results are very significant considering that most of the fluids in these ultra-low matrix permeability reservoirs get produced through the interconnected natural fractures, which are expected to have very low fracture conductivities. We also expect sharp pressure drops near the fractures in these shale gas reservoirs, and it is very unrealistic to expect the hydraulic fractures or complex fracture networks to be orthogonal to any structured grid. In conclusion, this paper presents an open-source numerical framework to facilitate the modeling of the expected physical mechanisms in shale-gas reservoirs. The code was validated against published results and a commercial simulator. We also performed a history-matching study on a naturally-fractured Barnett shale-gas well considering adsorption, gas slippage & diffusion and fracture closure as well as proppant embedment, using the framework presented. This work provides the first open-source code that can be used to facilitate the modeling and optimization of fractured shale-gas reservoirs. To provide the numerical flexibility to accurately model stochastic natural fractures that are connected to hydraulically-fractured wells, it is built atop other related open-source codes. We also present the first rigorous study on the accuracy of using EDFM to model both hydraulic fractures and natural fractures that may or may not be interconnected.

Preprint ARTICLE | doi:10.20944/preprints201704.0001.v1

A Theoretical Study and Numerical Simulation of a Quasi-Distributed Sensor Based on the Low-Finesse Fabry-Perot Interferometer: Frequency-Division Multiplexing

José Trinidad Guillen Bonilla, Alex Guillén-Bonilla, Rodríguez-Betancourtt Veronica M., Héctor Guillen Bonilla, Antonio Casillas Zamora

Subject: Engineering, Electrical And Electronic Engineering Keywords: Quasi-distributed sensor; Low-finesse Fabry-Perot interferometer; Sensor simulation; Frequency-domain multiplexing and resolution vs. signal-to-noise ratio

Online: 3 April 2017 (15:56:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints201906.0219.v1

A Mini-Review on the Phytochemistry and Biological Activities of Selected Apocynaceae Plants

Abiche Ekalu, Rachael Gbekele-Oluwa Ayo, Habila D. James, Ibrahim Hamisu

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: phytochemistry; biological activities; Apocynaceae family

Online: 21 June 2019 (18:28:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0059.v1

Fluid Flow and Mixing Induced by AC Continuous Electrowetting of Liquid Metal Droplet

Qingming Hu, Yukun Ren, Weiyu Liu, Xiaoming Chen, Ye Tao, Hongyuan Jiang

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: Mixer; Marangoni chaotic advection; continuous electrowetting; liquid metal droplet

Online: 13 March 2017 (07:58:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0047.v1

Structure Modification of an Active Azo-Compound as a Route to New Antimicrobial Compounds

Simona Concilio, Lucia Sessa, Anna Maria Petrone, Amalia Porta, Rosita Diana, Pio Iannelli, Stefano Piotto

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: azo-compound; antimicrobial; synthesis; QSAR.

Online: 5 May 2017 (13:38:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0006.v1

Immunization with E Plus NS1-2a Enhanced Protection against Dengue Virus Serotype 2 in Mice

Yanhua Wu, Shuyu Fang, Xiaoyun Cui, Na Gao, Dongying Fan, Jing An

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Dengue virus; E; NS1-2a; electroporation; DNA vaccine

Online: 1 December 2016 (10:37:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0229.v1

Water Quality Dynamics of Urban Water Bodies During Flooding in Can Tho City, Vietnam

Hong Quan Nguyen, Mohanasundar Radhakrishnan, Thi Thao Nguyen Huynh, Maria Luisa Baino-Salingay, Long Phi Ho, Peter Van der Steen, Assela Pathirana

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Can Tho city; extreme event; urban flooding; water quality monitoring; water pollution

Online: 31 March 2017 (09:50:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0221.v1

Ultra-low Anti-reflection Coating on a Plastic Cover Slip in Liquid for He-Ne Laser Light

Jin-Cherng Hsu, Heng-Ying Cho, Tsang-Yen Hsieh, Jyh-Liang Wang

Subject: Physical Sciences, Optics And Photonics Keywords: ultra-low anti-reflection coating; ellipsometer; optical admittance method

Online: 31 May 2017 (11:50:18 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201807.0200.v1

White-Tailed Sea Eagle (Haliaeetus Albicilla) Die-Off due to Infection with Highly Pathogenic Influenza Virus, Subtype H5N8, in Germany

Oliver Krone, Anja Globig, Reiner Ulrich, Timm Harder, Jan Schinköthe, Christof Herrmann, Sascha Gerst, Franz J. Conraths, Martin Beer

Subject: Biology And Life Sciences, Virology Keywords: clade 2.3.4.4b; fatal infection; avian flu; HPAIV H5N8; neurological symptoms; bird of prey; raptor

Online: 11 July 2018 (12:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0047.v2

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

Ashutosh Kumar, Pavan Kumar, Muneeb A. Faiq, Vikas Pareek, Khursheed Raza, Sankat Mochan, Pranav Prasoon, Vivek Sharma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: HPA axis; NGFs; psychiatric disorders; prevention of mental diseases; stress

Online: 4 December 2017 (07:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0048.v1

Public Understanding and Attitudes towards Meat Chicken Production and Relations to Consumption

Ihab Erian, Clive J. C. Phillips

Subject: Social Sciences, Sociology Keywords: animal welfare; attitudes; chicken; knowledge; consumption; poultry

Online: 8 March 2017 (07:35:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0490.v1

Correction of the Sickle Cell Mutation Through Base and Prime Editing in Hematopoietic Stem Cells

Kelly Ji

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: base editing; prime editing; ABE; SCD; sickle cell disease; sickle cell anemia; CRISPR; Cas9

Online: 21 September 2020 (04:23:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0107.v1

Maximum Storm Tide Response to the Intensity of Typhoons and Bathymetric Changes along the East Coast of Taiwan

Wen-Cheng Liu, Wei-Bo Chen, Lee-Yaw Lin

Subject: Engineering, Control And Systems Engineering Keywords: maximum storm tide; two-dimensional tide-surge modeling system; east coast of Taiwan; intensity of typhoon; bathymetric rise

Online: 28 February 2017 (13:00:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0121.v1

Antibacterial Activity of Ethanolic Extract of Cinnamon Bark and Honey and Their Combination Effects Against Acne Causing Bacteria

Elin Julianti, Kasturi K. Rajah, Irda Fidrianny

Subject: Medicine And Pharmacology, Dermatology Keywords: antibacterial activity, cinnamon, honey, checkerboards method, synergistic activity

Online: 23 December 2016 (18:37:59 CET)

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Preprint REVIEW | doi:10.20944/preprints201706.0046.v1

A Critical Review on Predicting Fouling in RO Desalination

Alejandro Ruiz-García, Noemi Melián-Martel, Ignacio Nuez

Subject: Engineering, Chemical Engineering Keywords: Reverse osmosis; Membrane fouling; Fouling indices; Predicting models

Online: 9 June 2017 (11:04:40 CEST)

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Preprint COMMUNICATION | doi:10.3390/sci1030024

Power Laws and Elementary Particle Decays

Leonardo Chiatti

Subject: Physical Sciences, Particle And Field Physics Keywords: elementary particle decays; emergence; power laws

Online: 13 November 2019 (00:00:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0030.v1

Warming and Eutrophication Effects on Phytoplankton Community of Two Tropical Systems with Different Trophic States—An Experimental Approach

Andreia Maria Da Anunciação Gomes, Marcelo Manzi Marinho, Marcella Coelho Berjante Mesquita, Ana Carolina Coelho Prestes, Miquel Lürling, Sandra Maria Feliciano De Oliveira E Azevedo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: global warming; nutrients addition; cyanobacterial blooms; eutrophic systems; oligo-mesotrophic systems

Online: 3 May 2017 (09:39:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0233.v1

Optimization Simulation of the Light Aircraft’s Cockpit Made of Carbon Fiber Reinforced Composites

Pu-Woei Chen, Chia-Hung Liu

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: light aircraft; crashworthiness; topology optimization; composites materials; finite element analysis

Online: 31 March 2017 (11:13:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0546.v1

Aerosol Particles Laden with COVID-19 Travel Over 30m Distance

Boris Gorbunov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; face masks; aerosol; infection transmission route; weather conditions; viral load; exposure; dose

Online: 30 April 2020 (17:29:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0649.v1

Modern Clinical Text Mining: A Guide and Review

Bethany Percha

Subject: Computer Science And Mathematics, Information Systems Keywords: text mining; natural language processing; electronic health records; clinical text; machine learning

Online: 30 October 2020 (15:01:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0070.v1

Plasma Based Water Purifier: Design And Testing of Prototype with Different Samples of Water

Suraj M, Anuradha T

Subject: Engineering, Chemical Engineering Keywords: Plasma generation, non-thermal Plasma, pulsating DC power, Ozone, cost-improvement

Online: 4 September 2018 (14:56:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0213.v1

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and in Vitro Testing

Berin Karaman, Zayan Alhalabi , Sören Swyter, Shetonde O. Mihigo, Kerstin Andrae-Marobela, Manfred Jung , Wolfgang Sippl , Fidele Ntie-Kang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: bichalcones; sirtuin inhibitors; virtual screening

Online: 23 January 2018 (09:12:43 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201610.0058.v2

Local Electrical Response in Alkaline-Doped Electrodeposited CuInSe₂/Cu Films

Javier A. Barón-Miranda, Octavio Calzadilla, Liliana E. Arvizu-Rodríguez, Jose L. Fernandez-Muñoz, Cesia Guarneros-Aguilar, Fabio F. Chalé-Lara, Ulises Páramo-García, Felipe Caballero-Briones

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: CuInSe2 electrodeposition; alkaline doping; current sensing atomic force microscopy

Online: 18 December 2016 (09:48:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0333.v2

2-Deoxy-d-glucose Inhibits Replication of Novel Coronavirus (SARS-CoV-2) with Adverse Effects on Host Cell Metabolism

Vikas Malgotra, Varun Sharma

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: 2-Deoxyglucose; Adverse effects; COVID-19; Glutamine; PI3K/Akt

Online: 1 July 2021 (13:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0473.v1

A Short-Term Forecast Scenario for COVID-19 Epidemic and Allocated Hospital Readiness in Egypt

Engy El-Ghitany

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Egypt; prediction exponential growth rate; hospital preparedness

Online: 27 April 2020 (03:27:47 CEST)

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BackgroundThe novel virus COVID-19, also known as SARS-CoV‑2, is currently rapidly spreading around the globe and pushing healthcare systems to the limits of their capacity. One of the functions of predictive models is to timely act for epidemic preparedness including hospital preparedness. In Egypt, like many other countries in the world, the epidemic situation and forecasting have not yet sufficiently studied. ObjectiveThe study was carried out to develop a short-term forecast scenario for the COVID-19 epidemic situation in Egypt and predict the hospital needs to accommodate the growing number of cases.MethodsSecondary data from the COVID-2019 daily reports and the report issued 8^thof April by the Egyptian Ministry of Health and Population were used. Due to the daily changing level of knowledge and data, the article reflects the status up to 18 April 2020. The prediction was based on the exponential growth rate model. For the depiction of the situation, the full length of the epidemic timeline was analyzed (from February 14^th till April 18^th). The growth rates and their rates of decline during the period from the 22^nd of March till the 18^th of April were calculated and extrapolated in the coming 7 weeks. The predicted hospital needs were assessed against the announced allocated resources.ResultsThe epidemic curve in Egypt is on the ascending arm as of April, 18. The active cases showed exponential growth from the start of the epidemic till April, 18. At the end of this period time, the recovery rate was 23.12% and the case fatality rate (CFR) was7.39. The case fatality rate median level during the last four weeks was 6.64. The active cases are expected to reach more than 20,000 by late May then starts to decline. The allocated regular hospital beds are predicted to show shortage by the time of the release of the paper. The intensive care units (ICU) beds and ventilators are predicted to show insufficiency on May 6.Conclusions: The COVID-19 epidemic in Egypt is expected to continue on the rise for the next few weeks and expected to start to decline late in May, 2020. Our estimates should be useful in preparedness planning. Serious actions should be taken to provide ICU beds and ventilators enough for the predicted number of cases that would need them, not later than the end of April. Mitigation actions have to continue for the coming 6 weeks or until the epidemic situation is more clearly seen.

Preprint TECHNICAL NOTE | doi:10.20944/preprints201611.0098.v1

Nonlinear Vibration Response of a Rectangular Tube with a Flexible End and Non-Rigid Acoustic Boundaries

Y. Y. Lee

Subject: Engineering, Mechanical Engineering Keywords: nonlinear plate vibration; structural acoustics; harmonic balance method

Online: 18 November 2016 (10:13:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201711.0026.v1

Thyroid Disrupting Chemicals

Valeria Calsolaro, Giuseppe Pasqualetti, Filippo Niccolai, Nadia Caraccio, Fabio Monzani

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Thyroid; Thyroid Hormone; Disrupting Compound; Hypothalamus Pituitary Thyroid axis; TSH

Online: 3 November 2017 (12:38:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0077.v1

The Pathophysiology of Virulence of the COVID-19 Virus

Joseph De Soto, Shazia Hakim, Frederick Boyd

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; native American Indian; treatment; ACE2 receptor; pathophysiology; virulence

Online: 7 April 2020 (02:40:24 CEST)

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Background: On Dec 19, 2019 it was reported by the public health department of China that an outbreak of pneumonia was caused by a novel Coronavirus. The virulence of the new virus COVID-19 was much greater than either the SARs or MERSs viruses and on March 11, 2020 the World Health Department (WHO) declared world -wide pandemic. Understanding the pathophysiology of virulence of the COVID-19 virus is absolutely necessary in understanding the transmission, virulence factors, reduce risk factors, clinical presentation, predict outcomes of the disease and provide guidance to any current or future treatment protocols. Methodology: A PubMed search was performed utilizing the words: Wuhan Virus, COVID-19, SARs coronavirus, ACE2, S protein, virulence, clinical presentation, epidemiology, genome, treatment, structure, MERs, pathogenesis and/or pathology alone and in combination with other terms. Each paper was evaluated by three content experts for quality, reproducibility, credibility and reputation of the journal. Results: The COVID-19 virus is much more virulent than either the SARs or MERs virus and its ability to cause serious disease inversely corresponds to the person’s ability to produce T-cells which declines linearly with age. The ACE2 receptor binding site do not vary among different ethnic groups but do in expression levels. This variance in expression level may explain for different infectivity rates among men and women and predict and explain different susceptibilities to infection by different ethnic groups. Furthermore, by understanding the underlying pathophysiology one can explain and provide guidance to the clinical effectiveness of any treatment. Conclusions: The underlying pathophysiology of COVID-19 explains not only the virulence, and clinical presentation, but, explains at a molecular level the comorbidity risk factors such as hypertension, sex, and age. Ethnic and anatomic expression patterns of ACE-2 and associated pathophysiology suggests that Native Americans and Asians may be particularly susceptible to this disease.

Preprint ARTICLE | doi:10.20944/preprints201704.0119.v1

Modified Adversarial Hierarchical Task Network Planning in Real-Time Strategy Games

Lin Sun, Peng Jiao, Kai Xu, Quanjun Yin, Yabing Zha

Subject: Computer Science And Mathematics, Computer Science Keywords: HTN planning; real-time strategy game; plan repair

Online: 19 April 2017 (04:41:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0228.v1

Hydrogen Storage Characteristics and Corrosion Behavior of V-rich Ti-V-Cr-Fe Alloy

Jimoh Mohammed Abdul, Lesley Hearth Chown, Jamiu K. Odusote, Jean Nei, Kwo-Hsiung Young, Woli Taiye Olayinka

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Ti-V-Cr-Fe alloy; hydrogen storage characteristics; metal corrosion; heat treatment; crystal structure

Online: 31 March 2017 (09:19:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints201701.0006.v1

Ex-Situ vs. In-Situ Defluoridation of the Contaminated Aquifers: A State-of-the-Art Review

Meenakshi Arora, Nibha Gupta

Subject: Engineering, Chemical Engineering Keywords: Fluoride, groundwater, in-situ remediation, pump and treat

Online: 2 January 2017 (13:57:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0251.v1

Analysis of Morphological, Physiological, and Biochemical Traits of Salt Stress Tolerance in Asian Rice Cultivars at Different Stages

Maha A. Alshiekheid, Yheni Dwiningsih, Jawaher Alkahtani

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Asian rice; salt stress; morphology; physiology; biochemistry

Online: 14 March 2023 (06:51:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0100.v1

Evaluation of MODIS Albedo Product over Ice Caps in Iceland and Impact of Volcanic Eruptions on Their Albedo

Simon Gascoin, Sverrir Guðmundsson, Guðfinna Aðalgeirsdóttir, Finnur Pálsson, Louise Schmidt, Etienne Berthier, Helgi Björnsson

Subject: Environmental And Earth Sciences, Environmental Science Keywords: glacier; albedo; volcanic eruption

Online: 28 February 2017 (11:12:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0065.v1

Using the HEXACO Model of Personality to Test the Validity of the Durand Adaptive Psychopathic Traits Questionnaire

Guillaume Durand

Subject: Social Sciences, Psychology Keywords: DAPTQ; adaptive personality; psychometric properties; HEXACO; psychopathic personality traits; confirmatory factor analysis; test-retest validity

Online: 14 June 2017 (07:47:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0257.v1

Magnetic Field of a Linear Quadrupole Using the Magnetic Sensors Inside the Smartphones

Isabel Escobar, Raquel Ramirez-Vazquez, Jesus Gonzalez-Rubio, Augusto Belendez, Enrique Arribas

Subject: Physical Sciences, Particle And Field Physics Keywords: smartphone; magnetic sensor, magnetic field; lab physics; quadrupole

Online: 26 January 2018 (16:17:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0018.v1

Development of Non-Enzymatic Glucose Biosensors Based on Electrochemically Prepared Polypyrrole-Chitosan-Titanium Dioxide Nanocomposite Films

ALI M.A. Abdul Amir AL-Mokaram, Rosiyah Yahya, Mahnaz M. Abdi, Habibun Nabi Muhammad Ekramul Mahmud

Subject: Chemistry And Materials Science, Electrochemistry Keywords: nanomaterials; non-enzymatic glucose biosensors; nanocomposites; electrodeposition; titanium dioxide nanocomposite; XPS; EIS.

Online: 4 April 2017 (09:27:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0108.v1

Non-Equilibrium Phase Behavior of Hydrocarbons in Compositional Simulations and Upscaling

Ilya M. Indrupskiy, Olga A. Lobanova, Vadim R. Zubov

Subject: Engineering, Energy And Fuel Technology Keywords: non-equilibrium phase behavior; compositional flow simulations; phase transitions; upscaling; hydrocarbon mixtures; non-equilibrium constant volume depletion

Online: 18 April 2017 (04:05:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0035.v1

Models of Automation Surprise: Results of a Field Survey in Aviation

Robert J. de Boer, Sidney W. A. Dekker

Subject: Social Sciences, Decision Sciences Keywords: aviation automation; automation surprise; cognition; complacency; bias

Online: 6 March 2017 (17:59:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0637.v1

A Systematic Analysis of the Effectiveness of Mitochondrial-Based Therapies for the Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Leif Gerrit Keferstein

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Myalgic Encephalomyelitis; chronic fatigue syndrome; therapeutic strategies; personalized treatment; pathophysiology; pharmacological treatments; nutritional supplements; dietary changes; physical therapies; lifestyle modifications

Online: 10 October 2023 (11:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0027.v1

Incomplete Segregation of MSH6 Frameshift Variants with Phenotype of Lynch Syndrome

Raffaella Liccardo, Marina De Rosa, Giovanni Battista Rossi, Nicola Carlomagno, Paola Izzo, Francesca Duraturo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Lynch syndrome; segregation analysis; MSH6 gene; hereditary colorectal cancer; oligogenic model

Online: 5 April 2017 (03:04:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0036.v1

Optimization of the COD Removal Efficiency for a Static Granular Bed Reactor Treating Poultry Slaughterhouse Wastewater

Zainab Rinquest, Moses Basitere, Maxwell Mewa-Ngongang, Seteno Karabo Obed Ntwampe, Mahomet Njoya

Subject: Engineering, Other Keywords: Anaerobic digestion; Chemical oxygen demand; Optimization; Poultry slaughterhouse wastewater; Response surface methodology; Static Granular Bed Reactor

Online: 4 February 2019 (13:53:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0060.v1

FLYDE Plate: Open Source Anesthesia Labware for Drosophila Fly-Pushing!

Jordan Hyde, Tristan A.F. Long

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: open source; 3D printing; Drosophila; laser cutter; lab equipment; open labware; fly-pushing; fly pad; fly plate; CO2 anesthesia

Online: 6 May 2019 (11:51:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0021.v1

Impacts of Land Cover and Seasonal Variation on Maximum Air Temperature Estimation Using MODIS Imagery

Yulin Cai, Gang Chen, Yali Wang, Li Yang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: maximum surface air temperature; land surface temperature; statistical modeling; MODIS

Online: 3 March 2017 (08:38:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0207.v1

Diffusion-Weighted MRI and Urinary Activin-A are Correlated with the Degree of Hypoxic Ischemic Encephalopathy in Neonates

Sheren Maher, Mohamed Abdelazim, Mohamed Eissawy, Mahmoud Higazi, Nagwa Okaily

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Activin-A; HIE; MRI; apparent diffusion coefficient; neonates

Online: 28 March 2017 (03:07:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0178.v1

A Density-Based Clustering Method for Urban Scene Mobile Laser Scanning Data Segmentation

You Li, Lin Li, Dalin Li, Fan Yang, Yu Liu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: mobile laser scanning; voxel; clustering; segmentation

Online: 23 March 2017 (08:48:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0101.v1

Toxicity and Biodegradability of Solvents: A Comparative Analysis

Asghar Sadeghi

Subject: Biology And Life Sciences, Toxicology Keywords: toxicity; biodegradability; industrial solvents; ionic liquids; freshwater organisms

Online: 19 December 2016 (11:18:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0119.v1

Processes of Direct Laser Writing 3D Nano-Lithography

Simonas Varapnickas, Mangirdas Malinauskas

Subject: Physical Sciences, Applied Physics Keywords: 3D nano-lithography, 3D laser lithography, direct laser writing, nanopolymerization, cross-linking, multi-photon absorption, avalanche ionization, temperature effects

Online: 11 December 2018 (09:31:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0036.v1

A Global Seamless DEM Based on Multi-Source Data Fusion (GSDEM-30): Product Generation and Evaluation

Linwei Yue, Huanfeng Shen, Lu Liu, Qiangqiang Yuan, Liangpei Zhang

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: digital elevation models; multi-source fusion; multi-scale fusion; global evaluation; accuracy validation.

Online: 5 June 2019 (10:26:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202002.0156.v1

Clinical Reports on Early Diagnosis of Novel Coronavirus (2019-nCoV) Pneumonia in Stealth Infected Patients

Yang Zhou, Le Yang, Ming Han, Mingqiang Huang, Xuedong Sun, Weidong Zhen, Junqing Xu, Jinhong Wang, Wei Han

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: 2019-nCoV; Chest CT; Epidemic; Diagnosis

Online: 12 February 2020 (09:14:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0298.v1

Government Initiatives for Green Development in Bangladesh

Md. Anowar Hossain Bhuiyan, Shafiqul Hassan, Md. Abud Darda, Md. Wahidul Habib, Md. Belal Hossain

Subject: Social Sciences, Government Keywords: Bangladesh; Government; Green development

Online: 13 August 2020 (10:22:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0087.v3

Real-Life/Real-Time Elderly Fall Detection with a Triaxial Accelerometer

Angela Sucerquia, Jose David López, Francisco Vargas-Bonilla

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: triaxial accelerometer; wearable devices; fall detection; mobile health-care; SisFall; Kalman filter

Online: 6 February 2018 (05:37:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0097.v1

The Impact of Pelvic Floor Muscles Exercises with and without Synergistic Muscles on Quality of Life of Women with Stage I Stress Urinary Incontinence

Magdalena Ptak, Agnieszka Brodowska, Sylwester Ciećwież, Iwona Rotter

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: LUTS; stress urinary incontinence; perimenopause; pelvic floor

Online: 27 February 2017 (17:41:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0155.v1

Cancer-associated Fibroblasts: Origins, Heterogeneity and Functions in Tumor Microenvironment

Kevin Dzobo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Tumor microenvironment; tumor stroma; cancer-associated fibroblasts; heterogeneity; biomarkers; cancer; The Cancer Genome Atlas; gene expression; computational biology

Online: 15 January 2020 (12:56:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0262.v1

ACE-1 I/D Polymorphism Associated with COVID-19 Incidence and Mortality: An Ecological Study

Chris Kenyon

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: angiotensin-converting enzyme; I/D polymorphism; ACE; SARS-CoV-2; COVID-19 mortality rate; testing intensity

Online: 16 April 2020 (08:04:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0197.v1

Scholarship Suppression: Theoretical Perspectives and Emerging Trends

Sean Stevens, Lee Jussim, Nathan Honeycutt

Subject: Social Sciences, Psychology Keywords: free speech; academic freedom; scholarship suppression; moral panics; witch hunts

Online: 9 September 2020 (03:45:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0083.v1

Key for Identification of the Ladybirds (Coleoptera: Coccinellidae) of European Russia and Russian Caucasus (Native and Alien Species)

Andrzej O. Bienkowski

Subject: Environmental And Earth Sciences, Ecology Keywords: ladybeetles; guide for identification; aborigenous species; introduced species

Online: 12 March 2018 (06:54:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0100.v1

An Energy Demodulation Based Fiber Optic Sensing System for Landslide Early-Warning

Xing Wang, Bin Shi, Guangqing Wei, Shenen Chen

Subject: Engineering, Civil Engineering Keywords: landslides; fiber optic sensing system; early-warning; energy demodulation; event sensor

Online: 17 April 2017 (12:10:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0386.v1

A New Health Assessment Prediction Approach: Multi-Scale Ensemble Extreme Learning Machine

BERGHOUT Tarek

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: remaining useful life; c-mapss; extreme learning machine; prognostic and health management; neural networks

Online: 24 May 2020 (16:24:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0149.v1

Evaluation of Rational Drug Use for Acute Pharyngitis Associated with the Incidence and Prevalence of the Disease at Two Community Health Centers in Indonesia

Cindra T. Yuniar, Kusnandar Anggadiredja, Alfi N. Islamiyah

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: acute pharyngitis; rational use of drugs; incidence; prevalence

Online: 30 December 2016 (07:37:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0094.v1

Synthesis, Characterization and Catalytic Performance of Well-ordered Crystalline Heteroatom Mesoporous MCM-41

Jing Qin, Baoshan Li

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: bulk crystal mesoporous MCM-41; heteroatom molecular sieves; direct hydrothermal method

Online: 18 December 2016 (10:30:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0013.v1

Trigonometric Cubic B-spline Collocation Method for Solitons of the Klein-Gordon Equation

Alper Korkmaz, Ozlem Ersoy, Idiris Dag

Subject: Computer Science And Mathematics, Mathematics Keywords: Klein-Gordon equation; trigonometric cubic B-spline; collocation; soliton; wave motion; conservation laws

Online: 2 December 2016 (08:45:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0337.v1

Alcohol-Based Hand Sanitizers – A Multidimensional Perspective

Nasser N. Nyamwweya, Kennedy O. Abuga

Subject: Public Health And Healthcare, Primary Health Care Keywords: hand sanitizers; hand rubs; alcohol based; disinfection; hand hygiene; coronavirus; COVID-19

Online: 15 September 2020 (09:07:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0013.v1

Persons with Rheumatoid Arthritis Challenge the Relevance of the Health Assessment Questionnaire: A Qualitative Study of Patient Perception

David Ebbevi, Anna Essén, Helena Hvitfeldt Forsberg

Subject: Public Health And Healthcare, Nursing Keywords: Rheumatoid Arthritis; thematic analysis; Outcomes assessment; Qualitative Research; Patient reported outcome measures

Online: 3 January 2017 (11:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0188.v1

A Study on Optimal D-InSAR Filtering Technique According to Landform Relief

Youm Minkyo, Yun Hongsic, Kim Kwangbae, Kim Hanbual, Lee Woneung

Subject: Engineering, Civil Engineering Keywords: D-InSAR; Coherence; Goldstein; Boxcar-filter

Online: 24 March 2017 (11:02:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0121.v1

The Use of Destructive and non Destructive Testing in Concrete Strength Assessment for a School Building

Vincenzo Minutolo, Stefania Di Ronza, Caterina Eramo, Renato Zona

Subject: Engineering, Civil Engineering Keywords: non destructive testing; concrete structure; Sonreb; ultrasonic testing; rebound index

Online: 13 June 2019 (13:06:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0092.v2

Variability of Darcian Flux in the Hyporheic Zone at a Natural Channel Bend

Shaofeng Xu, Jinxi Song, Weiwei Jiang, Guotao Zhang, Ming Wen, Junlong Zhang, Ying Xue

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: hyporheic zone; Darcian flux; channel bend; vertical hydraulic conductivity; stream topography; grain size; porosity

Online: 26 February 2017 (10:07:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0194.v1

LC-MS/MS Tandem Mass Spectrometry for Analysis of Phenolic Compounds and Pentacyclic Triterpenes in Antifungal Extracts of Terminalia brownii (Fresen)

Enass Y. A. Salih, Pia Fyhrquist, Ashraf M. A. Abdalla, Abdelazim Y. Abdelgadir, Markku Kanninen, Marketta Sipi, Olavi Luukkanen, Mustafa K. M. Fahmi, Mai H. Elamin, Hiba A. Ali

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Africa; Terminalia brownii; antifungal extracts; Aspergillus, Nattrassia, Fusarium; triterpenoids; flavonoids; ellagitannins; stilbenes

Online: 31 October 2017 (09:54:35 CET)

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Decoctions, macerations and fumigations of the stem bark and wood of Terminalia brownii Fresen. are used in traditional medicine for fungal infections and as pesticides on field crops and in traditional granaries in Sudan. In addition, T. brownii is commonly used for protecting wooden houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts of various polarities from the stem wood and bark were screened for their growth inhibitory effects against filamentous fungi commonly causing fruit, vegetable and grain decay, as well as infections in the immunocompromised host. Ethyl acetate extracts of the stem wood and bark gave the best antifungal activities, with MIC values of 250 µg/ml against Nattrassia mangiferae and Fusarium verticillioides, and 500 µg/ml against Aspergillus niger and Aspergillus flavus. Aqueous extracts gave almost as potent effects as the ethyl acetate extracts against the Aspergillus and Fusarium strains, and were slightly more active than the ethyl acetate extracts against Nattrassia mangiferae. Thin layer chromatography, RP-HPLC-DAD and tandem mass spectrometry (LC-MS/MS), were employed to identify the chemical constituents in the ethyl acetate fractions of the stem bark and wood. The stem bark and wood were found to have a similar qualitative composition of polyphenols and triterpenoids, but differed quantitatively from each other. The stilbene derivatives, cis- (3) and trans- (4) resveratrol-3-O-β-galloylglucoside, were identified for the first time in T. brownii. Moreover, methyl-(S)-flavogallonate (5), quercetin-7-β-O-di-glucoside (8), quercetin-7-O-galloyl-glucoside (10), naringenin-4`-methoxy-7-pyranoside (7), 5,6-dihydroxy-3`,4`,7-tri-methoxy flavone (12), gallagic acid dilactone (terminalin) (6), a corilagin derivative (9) and two oleanane type triterpenoids (1) and (2) were characterized. Our results justify the traditional uses of macerations and decoctions of T. brownii stem wood and bark for crop and wood protection and demonstrate that standardized extracts could have uses for the eco-friendly control of plant pathogenic fungi in African agroforestry systems. Likewise, our results justify the traditional uses of these preparations for the treatment of skin infections caused by filamentous fungi.