Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

ACE-1 I/D Polymorphism Associated with COVID-19 Incidence and Mortality: An Ecological Study

Version 1 : Received: 15 April 2020 / Approved: 16 April 2020 / Online: 16 April 2020 (08:04:35 CEST)

How to cite: Kenyon, C. ACE-1 I/D Polymorphism Associated with COVID-19 Incidence and Mortality: An Ecological Study. Preprints 2020, 2020040262 (doi: 10.20944/preprints202004.0262.v1). Kenyon, C. ACE-1 I/D Polymorphism Associated with COVID-19 Incidence and Mortality: An Ecological Study. Preprints 2020, 2020040262 (doi: 10.20944/preprints202004.0262.v1).

Abstract

A literature review was conducted to summarize the frequency of the D-allele of the angiotensin-converting enzyme-1 in all countries with available data. Using an ecological study design limited to high income countries, we found that the country-level frequency of the D-allele was associated with increased COVID-19 incidence and mortality.

Subject Areas

angiotensin-converting enzyme; I/D polymorphism; ACE; SARS-CoV-2; COVID-19 mortality rate; testing intensity

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