Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Oral Mucositis: Melatonin Gel an Effective New Treatment

Version 1 : Received: 8 March 2017 / Approved: 9 March 2017 / Online: 9 March 2017 (04:46:30 CET)

A peer-reviewed article of this Preprint also exists.

Abdel Moneim, A.E.; Guerra-Librero, A.; Florido, J.; Shen, Y.-Q.; Fernández-Gil, B.; Acuña-Castroviejo, D.; Escames, G. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int. J. Mol. Sci. 2017, 18, 1003. Abdel Moneim, A.E.; Guerra-Librero, A.; Florido, J.; Shen, Y.-Q.; Fernández-Gil, B.; Acuña-Castroviejo, D.; Escames, G. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int. J. Mol. Sci. 2017, 18, 1003.

Abstract

The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, melatonin, whose role in the treatment of mucositis has recently been investigated, offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients’ lives.

Keywords

mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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