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Preprint ARTICLE | doi:10.20944/preprints202306.0564.v1

A Sustainable Green Synthesize of Nanocomposite of Silver Nanoparticles Functionalized with Pectin using Carpesium nepalense for Different Therapeutic Application: A Mechanistic Approach

Samiullah Burki, Muhammad Arif Asghar, Imdad Ali, Muhammad Asif Asghar, Zeba Gul Burki, Ibrahim Javed, Riaz Ullah

Subject: Medicinal Chemistry, Chemistry And Materials Science Keywords: Green Synthesis; Pectin functionalized silver nanoparticles; Antibacterial activity; Hepatoprotective

Online: 7 June 2023 (14:22:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0563.v1

Transparent Self-cleaning Coatings: A Review

Pengyuan Wu, Zhuanzhuan Xue, Tianxiang Yu, Oleksiy V. Penkov

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: self-cleaning coatings; wettability; durability; mechanical properties; prepare methods

Online: 7 June 2023 (13:41:50 CEST)

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Advanced coatings are essential to modern technologies, as they optimise surface characteristics for different application scenarios. Transparent and self-cleaning coatings are increasingly used as protective coatings for various applications, such as foldable touchscreens, windows, and solar panels. Moreover, incorporating other functionalities such as high hardness, wear resistance, and flexibility into transparent and self-cleaning coatings is important for broadening the use cases. Although many kinds of multifunctional coatings have been developed, it is still difficult to embody several properties in one coating adequately, as some properties, such as hardness and flexibility, are inherently contrastive. This review first describes basic principles, including wetting ability, photocatalytic reactions, photo-induced hydrophilic phenomena, and the implication of self-cleaning. The desired properties of multifunctional coatings are then listed, and methods for evaluating different properties are used. Recent progress in various preparation methods for multifunctional coatings, including the sol-gel, dip/spin, and chemical vapour deposition (CVD) methods, are also presented. Magnetron sputtering (MS) technology is widely used in coating preparation. Compared with chemosynthesis and CVD, MS is time-saving, suitable for industrial production, and environmentally friendly. Coatings prepared by MS usually possess excellent mechanical properties. Thus, we highlight the current research status of MS technology in multifunctional coating preparation. Moreover, according to the multilayer design structure of coatings, their optical and mechanical properties and self-cleaning ability can be controlled by combining the characteristics of different materials. Finally, combining photocatalytic materials such as TiO2 with other materials through a multilayer structure to obtain a multifunctional coating with excellent overall properties is discussed.

Preprint ARTICLE | doi:10.20944/preprints202306.0562.v1

Silica Fume Improves the Frost Resistance of Alkali-activated Slag/fly Ash Geopolymer Binder

Sen Wang, Yuqing Liang, Duosi Mo, Chonghui Zhang, Jiwei Xue, Xuewen Song, Yachao Wang

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: alkali-activated; freezing-thawing; fly ash; geopolymer; silica fume

Online: 7 June 2023 (13:34:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0561.v1

Integration of Indigenous and Local Knowledge in Policy and Practice of Nature-based Solutions in China: Progress and Highlights

Ruizi Yu, Quan Mu

Subject: Other, Environmental And Earth Sciences Keywords: nature-based solutions; indigenous and local knowledge; China

Online: 7 June 2023 (13:26:17 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.0560.v1

Pion-Argon Inclusive Cross-Section Measurement on ProtoDUNE-SP

Yinrui Liu

Subject: Nuclear And High Energy Physics, Physical Sciences Keywords: ProtoDUNE-SP; hadron beam; liquid argon; cross-section

Online: 7 June 2023 (13:24:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0559.v1

Cartilage Conduction Hearing Aids in Clinical Practice

Tadashi Nishimura, Hiroshi Hosoi, Ryota Shimokura, Tadashi Kitahara

Subject: Otolaryngology, Medicine And Pharmacology Keywords: Bone conduction; Cartilage conduction; Hearing device; Amplification; Aural atresia; Canal stenosis; Conductive hearing loss; Chronic otitis media

Online: 7 June 2023 (13:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0254.v2

Minimum Uncertainty as Bayesian Network Model Selection Principle

Grigoriy Gogoshin, Andrei Rodin

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: Bayesian Networks; probabilistic networks; conditional independence; model selection criteria; mutual information; sampling error; statistical uncertainty; MDL; BIC; AIC; BD; tRNA

Online: 7 June 2023 (13:20:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0558.v1

Ductile effect of PGA/PCL Blending Plastics using Novel Ionic Chain Extender with Non-Covalent Bonds

Hyuk Jun Kwon, Joseph Jang, Won-Gun Koh, Jun-Young Lee, Kiseob Hwang

Subject: Polymers And Plastics, Chemistry And Materials Science Keywords: Ionic chain extender; Non-covalent bonds; Ductility; Polyglycolic acid; Blending plastics

Online: 7 June 2023 (13:16:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0557.v1

Study of Viral Coinfection of the Ixodes Persulcatus Tickets Feeding on Humans in a Natural Foci of the South of the Far East

Galina Leonova, Larisa Somova, Svetlana Abramva, Evgeniy Pustovalov

Subject: Virology, Biology And Life Sciences Keywords: coinfection; tick Ixodes persulcatus; virus isolate; tick-borne encephalitis virus (TBEV); ectromelia virus; biological properties of co-isolate; electron microscopy; south of the Russian Far East

Online: 7 June 2023 (13:14:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0556.v1

Image Data Extraction and Driving Behavior Analysis Based on Geographic Information and Driving Data

Huei-Yung Lin, Jun-Zhi Zhang, Chin-Chen Chang

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: image data extraction; driving behavior analysis; geographic information system; global position system

Online: 7 June 2023 (13:09:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0555.v1

Exploration of a Filtration Model Variable Space using Machine Learning

Jeffrey Belding, Deena Hannoun

Subject: Water Science And Technology, Environmental And Earth Sciences Keywords: Filtration, Water Treatment, Water Management, Machine Learning, Run-to-Run Control

Online: 7 June 2023 (13:07:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0554.v1

Current Treatment Approach, Emerging Therapies and New Horizons in Systemic Lupus Erythematosus

Panagiotis Athanassiou, Lambros Athanassiou

Subject: Immunology And Allergy, Medicine And Pharmacology Keywords: systemic lupus erythematosus; treatment; hydroxychloroquine; corticosteroids; biologic agents; belimumab; rituximab; anifrolumab; tocilizumab; baricitinib

Online: 7 June 2023 (13:04:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0553.v1

Numerical Simulation of Sediment Transport in Unsteady Open Channel Flow

Jennifer G. Duan, Chunshui Yu, Yan Ding

Subject: Civil Engineering, Engineering Keywords: Dam-break flow; Godunov-type finite volume method; HLLC Riemann solver; Nonequilibrium sediment transport model; Variable density shallow water equations; Well-balanced property

Online: 7 June 2023 (12:57:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0552.v1

Building Ensemble of Resnet for Dolphin Whistle Detection

Loris Nanni, Daniela Cuza, Sheryl Brahnam

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Convolutional Neural Network; dolphin whistle; ensemble; spectrogram classification

Online: 7 June 2023 (12:54:44 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.0463.v2

Plastid Genome of Passiflora tripartita var. mollissima (poro-poro) from Huánuco, Peru

Flavio Aliaga, Mario Zapata-Cruz, Silvia Ana Valverde-Zavaleta

Subject: Biology And Life Sciences, Plant Sciences Keywords: Chloroplast genome; Passifloraceae; Passiflora tripartita; poro-poro; Huánuco; Peru

Online: 7 June 2023 (12:23:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0551.v1

Detection of Brain Tissue Damage in CO Poisoning with a New Method

Sedat Ozbay, Mustafa Ayan, Recep Eroz, Ayhan Saritas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Argyrophilic Nucleolus Organizer Region; Hypoxia; Brain; Carbon Monoxide Poisoning; Marker

Online: 7 June 2023 (12:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0550.v1

A Change in Global Sagittal Alignment after Transforaminal Epidural Steroids Injections in Lumbar Spinal Stenosis

Park Manakul, Koopong Siribumrungwong, Naphakkhanith Dhanachanvisith

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Global sagittal balance; Transforaminal epidural steroids injections; Lumbar spinal stenosis

Online: 7 June 2023 (12:10:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0549.v1

Hydraulic Response and Overtopping Performance of Single-Layer Double-Cube Unit Armored Mound Breakwater

Iman Safari, Dominique Mouazé, Soroush Aliasgary, Guillaume Carpentier, François Ropert

Subject: Engineering, Marine Engineering Keywords: Armor unit; Hydraulic Stability; Hydraulic performance; Turbulence; Roughness; Marine structures

Online: 7 June 2023 (12:07:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0548.v1

Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor Through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression

Kohei Yamada, Tomokazu Tanaka, Keita Kai, Shohei Matsufuji, Kotaro Ito, Yoshihiko Kitajima, Tatsuya Manabe, Hirokazu Noshiro

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: non-alcoholic steatohepatitis; hepatocellular carcinoma; farnesyltransferase inhibitor; hypoxia-inducible factor-1α; anti-inflammatory response; nuclear factor-κB; transforming growth factor-β; Warburg effect; reactive oxygen species; interleukin-6

Online: 7 June 2023 (12:05:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0547.v1

Structural & Tectonic Evolution of the Porgera Gold Mine; Highlands of Papua New Guinea

Kevin C. Hill, Gareth T. Cooper, Agnes Pokondepa, Peter Essy, Thiwaporn Phonsit, Mark Haydon

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Fold belt; Metasediments; Ore-body; Orogenesis; Pull-apart basin

Online: 7 June 2023 (11:57:26 CEST)

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The acquisition of regional, 1 metre resolution LIDAR in the PNG Highlands combined with 3D modelling in MoveTM has revolutionized our understanding of the evolution of the Porgera gold mine and areas of new potential. The new 3D model demonstrates active pull-apart basins along a regional transfer during ongoing fold and thrust deformation. When overlain on regional aeromagnetic data, new potential is revealed. The Porgera gold mine is one of the richest in the world and lies in a wide valley at an elevation of 2800m surrounded by mountains up to 4000m high in the middle of the PNG Highlands. It lies along a major lineament, the Porgera Transfer Zone (PTZ), cutting across the orogen that is associated with a 50 km offset of the ophiolite belt. To the NW of the mine there is an extensive belt of low- to high-grade metasediments that formed in deep water during Jurassic rifting, but were metamorphosed during Eocene subduction to the north. Subduction ceased due to accretion of the Sepik Terrane which caused inversion and mild erosion of the Porgera area. The Late Oligocene onset of wrenching in the Mobile Belt to the north placed that area into extension, emplacing metamorphic core complexes, and led to regional subsidence in the Early Miocene. Collision of the margin with the Melanesian Arc in the Middle Miocene caused Late Miocene to Pliocene orogenesis creating the broad mountain belt that we see today, that is still active, as shown by the 2018 MW 7.5 earthquake. Regional mapping of the area using high resolution LIDAR in association with limited field mapping, analysis of gravity and magnetics data and drilling of 300-500m deep core-holes has allowed development of a detailed 3D structural model. The Porgera valley is constrained laterally by the Eastern Boundary and Western Boundary dextral strike-slip faults that lie along the PTZ cutting across the orogeny. However, whilst the position and nature of the faults is clear, due to bending, fracturing and offset of major synclines and anticlines, the faults do not crop-out as significant through-going features. Rather, the dextral offset of basement is soft-linked to the Tertiary limestones at surface due to intervening thick, ductile Cretaceous shales. Fold and thrust structures are ubiquitous in the Tertiary limestones, but the youngest structural features are large extensional faults, particularly around the Porgera valley. The intrusive underlying the Porgera ore-body was emplaced at 6.0+-0.3 Ma, the time of maximum compression during orogenesis. At this time the Eastern Boundary fault and Western Boundary fault were both active allowing a pull-apart basin to form locally along the PTZ at the south-eastern boundary of the Jurassic metasediments. This enabled emplacement of the intrusive. The gold-bearing fluids from the intrusive and metasediments were brought up through the Mesozoic muds to the contact with the Paleogene carbonates where the Porgera ore body was emplaced.

Preprint ARTICLE | doi:10.20944/preprints202306.0546.v1

Improving the Efficiency of Radar Method for Monitoring Oil Spills on the Water Surface through the Use of an Active Antenna Array and Cosecant-squared Pattern

Vadim Anatolievich Shpenst, Artem Alekseevich Khalturin

Subject: Engineering, Control And Systems Engineering Keywords: remote sensing; oil spills; radar; phased active antenna array; cosecant-squared pattern diagram

Online: 7 June 2023 (11:47:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0513.v1

A Mathematical Model to Study the Potential Hepatitis B Virus Carriers and Effect of Vaccination Strategies in China

Chuanqing Xu, Yu Wang, Kedeng Cheng, Xin Yang, Xiaojing Wang, Songbai Guo, Maoxing Liu, Xiaoling Liu

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: HBV; potential HBV carriers; stability analysis; reproduction number; vaccine

Online: 7 June 2023 (11:40:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0545.v1

Genetic and Protein Expression Profile of Conjunctival Bleb Hyperfibrosis in Early Failure of Glaucoma Surgery

Elena Millá, Néstor Ventura-Abreu, Cristina Vendrell, Mª Jesús Muniesa, Marta Pazos, Xavier Gasull, Núria Comes

Subject: Medicine And Pharmacology, Ophthalmology Keywords: conjunctival filtration bleb; glaucoma surgery failure; conjunctival fibrosis; gene expression; profibrotic genes; fibrosis biomarker

Online: 7 June 2023 (11:37:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0544.v1

Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies

Mehmet Emin Arayıcı, Yasemin Basbinar, Hulya Ellidokuz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; meta-analysis; vitamin D; mortality; incidence

Online: 7 June 2023 (11:11:20 CEST)

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It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose of this paper was to elucidate the effects of Vit-D intake and serum 25-hydroxyvitamin-D (25(OH)D) levels on cancer incidence and mortality, the current evidence in this field, and the biases of this evidence using the meta-meta-analysis method. Meta-analyses focusing on Vit-D intake, serum 25(OH)D levels, and cancer risk/mortality were identified. A structured computer literature search was performed in PubMed/Medline, Web of Science (WoS), and Scopus electronic databases using predetermined keyword combinations. Primary and secondary meta-meta-analyses were carried out, combining odds ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) for outcomes reported in selected meta-analyses. A total of 35 eligible meta-analyses assessing the association between Vit-D and cancer incidence and/or mortality were included in this study. In the pooled analysis, higher Vit-D intake and serum 25(OH)D levels were associated with lower cancer risk (OR = 0.93, 95% CI: 0.90-0.96, p < 0.001; OR = 0.80, 95% CI: 0.72-0.89, p < 0.001, respectively) and cancer-related mortality (RR = 0.89, 95% CI: 0.86-0.93, p < 0.001; RR = 0.67, 95% CI: 0.58-0.78, p < 0.001, respectively). When meta-analyses whose primary reports included only randomized controlled trials were pooled, there was no significant association between Vit-D intake and cancer risk (OR = 0.99, 95% CI: 0.97-1.01, p = 0.320). In subgroup analysis, Vit-D consumption was associated with a significant decrease in colorectal and lung cancer incidence (OR = 0.89, 95% CI: 0.83-0.96, p = 0.002; OR = 0.88, 95% CI: 0.83-0.94, p < 0.001, respectively). Taken together, both Vit-D intake and higher 25(OH)D levels may provide remarkable benefits in terms of cancer incidence and mortality, however, careful evaluation according to cancer types is critically important and recommended.

Preprint ARTICLE | doi:10.20944/preprints202306.0543.v1

Minimal Length Deformation of Spacetime Curvature

Muhammad Maher, Abdel Nasser Tawfik, Fawzy Salah Tarabia, Fady Tarek Farouk

Subject: Physical Sciences, Theoretical Physics Keywords: Deformed theories of gravity; Noncommutative geometry; Curved spacetime; Relativity and gravitation; Deformed Spacetime Curvature

Online: 7 June 2023 (11:06:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0542.v1

Geographical Factors Determining the Transmission of COVID-19: Lessons Learned from Turkish Black Sea Region to Face Next Pandemic Crisis

Aytac Perihan Akan, Mario Coccia

Subject: Social Sciences, Other Keywords: COVID-19; Coronavirus Disease; SARS-CoV-2; Humidity; Rainfall; Coastal regions; Pandemic plans; Health Policy

Online: 7 June 2023 (11:03:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0541.v1

The Adoption of a Machine Learning Approach in a Big Data Concept to Predict Project Cost Budgeting in the Thai Auction Process of Procurement Management for a Construction Project

Wuttipong Kusonkhum, Korb Srinavin, Tanayut Chaitongrat

Subject: Engineering, Civil Engineering Keywords: Artificial neural network; Procurement management; Construction budgeting; Machine learning

Online: 7 June 2023 (10:50:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0540.v1

Reliability of Universal-Platform-Based VoiceScreen Application in AVQI Measurements Captured With Different Smartphones

Virgilijus Uloza, Nora Ulozaite Staniene, Tadas Petrauskas, Kipras Pribuišis, Tomas Blažauskas, Robertas Damaševičius, Rytis Maskeliūnas

Subject: Medicine And Pharmacology, Otolaryngology Keywords: VoiceScreen app; dysphonia screening; AVQI; smartphones

Online: 7 June 2023 (10:50:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0539.v1

The PPARα Agonist Fenofibrate Reduces the Levels of Proinflammatory Cytokines in a Maternal Immune Activation Model of Schizophrenia

Rafaela Mostallino, Michele Santoni, Claudia Sagheddu, Valentina Serra, Valeria Orrù, Marco Pistis, M. Paola Castelli

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: MIA; cytokines; chemokines; colony-stimulating factors; Poly (I:C); neurodevelopmental disorders

Online: 7 June 2023 (10:47:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0538.v1

Path Planning for Perpendicular Parking of Large Articulated Vehicles Based on Qualitative Kinematics and Geometric Methods

Inhwan Han

Subject: Engineering, Automotive Engineering Keywords: large articulated vehicles; automated perpendicular parking; geometric path plans; empirical methods; articulation angles; qualitative kinematics; uncertainties

Online: 7 June 2023 (10:44:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0537.v1

RELMα and Pulmonary Vascular Remodeling: a Multi-Strain Murine Model of Antigen and Urban Ambient PM Co-Exposure

Nedim Durmus, Wen Chi Chen, Sung-Hyun Park, Leigh Marsh, Sophia Kwon, Anna Nolan, Gabriele Grunig

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: resistin like molecule; pulmonary hypertension; type 2 inflammation; adaptive immune response; retnla; retnlb; retnlg; mouse strains; experimental pulmonary hypertension; urban PM; urban fine dust; immune response in pulmonary hypertension

Online: 7 June 2023 (10:40:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0536.v1

Wave Behavior Characteristics of Elastically Supported Fluid-Conveying Carbon Nanotubes under the Influence of Magnetic Fields

Qian Deng, Ming Li, Liufei Lv

Subject: Physical Sciences, Other Keywords: Fluid conveying carbon nanotubes; Timoshenko beams; Small-scale effects; Magnetic flux; Non-local strain gradients

Online: 7 June 2023 (10:39:43 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.0535.v1

Evaluation of Potential Predictive Biomarkers for Defining Brain Radiotherapy Efficacy in NSCLC Patients with Brain Metastases: A Case Report and Review of Literature

Angelo Luciano, Luigi Liguori, Giovanna Polcaro, Francesco Sabbatino, Stefano Pepe

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: brain metastases; NSCLC; predictive biomarkers for radiotherapy; radiotherapy; prognostic scores; WBRT; BRAF mutation

Online: 7 June 2023 (10:37:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0534.v1

Estimation of Cooling Rate of High-Strength Thick Plate Steel during Water Quenching Based on a Dilatometric Experiment

Hyo-Haeng Jo, Kyeong-Won Kim, Hyungkwon Park, Joonoh Moon, Young-Woo Kim, Hyun-Bo Shim, Chang-Hoon Lee

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: thick plate steel; water quenching; cooling rate; microstructure; hardness; dilatometry

Online: 7 June 2023 (10:29:09 CEST)

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The microstructure and hardness along the thickness direction of a water quenched, high-strength thick plate with a thickness of 40 mm were investigated with three specimens from the thick plate: surface, 1/4t, and 1/2t (center) thickness, and the phase transformation behavior of the thick plate according to the cooling rate was analyzed through dilatometric experiments. Finally, the cooling rate for each thickness of the thick plate was estimated by comparing the microstructure and hardness of the thick plate along the thickness with those of the dilatometric specimens. Martensite microstructure was observed on the surface of the water quenched thick plate due to the fast cooling rate. On the other hand, an inhomogeneous microstructure was transformed inside the thick plate due to the relatively slow cooling rate and central segregation of Mn. A small fraction of bainite was shown at 1/4t thickness. A banded microstructure with martensite and bainite resulting from Mn segregation was developed at 1/2t; that is, the full martensite microstructure was transformed in the Mn-enriched area even at a slow cooling rate due to high hardenability, but a bainite microstructure was formed in the Mn-depleted area owing to relatively low hardenability. A portion of martensite with fine cementite at the surface and 1/4t was identified as auto-tempered martensite with a Bagaryatskii orientation relationship between the ferrite matrix and cementite. The microstructure and hardness as well as dilatation were investigated at various cooling rates through a dilatometric experiment, and a continuous cooling transformation (CCT) diagram was finally presented for the thick plate. Comparing the microstructure and hardness at the surface, 1/4t, and 1/2t of the thick plate with those of dilatometric specimens cooled at various cooling rates, it was estimated that the surface of the thick plate was cooled at more than 20 oC/s, whereas the 1/4t region was cooled at approximately 5 ~ 10 oC/s during water quenching.

Preprint REVIEW | doi:10.20944/preprints202306.0533.v1

The Effects of Emotional Intelligence on Teachers’ Job Satisfaction: A Scoping Review

Grace Hulda, Xudong Zhu

Subject: Social Sciences, Education Keywords: Emotional intelligence; job satisfaction; teacher; Scoping review

Online: 7 June 2023 (10:16:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0525.v1

Recent Advances for the Synthesis of Dihydroquinolin-2(1H) ‑ones via Catalytic Annulation of α,β-unsaturated N-arylamides

Yan-Ning Niu, Lin-shuang Tian, Huai-Zhong Lv, And Ping-Gui Li

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 3,4-dihydroquinolin-2(1H)-one; α,β-unsaturated N-arylamides; radical; photochemical; annulation

Online: 7 June 2023 (10:12:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0475.v2

Effectiveness and Safety of Glucosamine in Osteoarthritis: A Literature Review

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Uyen Thi Thuc Che, Thanh Thi Thanh Ngo, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Osteoarthritis; Effectiveness; Safety; Glucosamine; systematic review

Online: 7 June 2023 (10:08:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0532.v1

Overestimation of Phonological Judgements on the Right Side of the Space

Patrizia Turriziani, Alessia Santostefano, Angela Catania, Massimiliano Oliveri

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Attention; phonological processing; space

Online: 7 June 2023 (10:04:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0531.v1

Construction of A Bis(benzene sulfonyl)imide Based Single-ion Polymer Artificial Layer for Steady Lithium Metal Anode

Yujie Wang, Mengmeng Zhao, Yazhou Chen, Haifeng Bao, Chen Li

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Lithium metal battery; lithium metal anode; polymeric artificial layer; single ion conductor; lithium dendrite.

Online: 7 June 2023 (09:43:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0530.v1

Hierarchical Clause Annotation: Building a Clause-Level Corpus for Semantic Parsing with Complex Sentences

Yunlong Fan, Bin Li, Yikemaiti Sataer, Miao Gao, Chuanqi Shi, Siyi Cao, Zhiqiang Gao

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Clause Hierarchy; Hierarchical Clause Annotation; Complex sentences; Semantic Parsing; Syntactic Parsing; RST corpus

Online: 7 June 2023 (09:41:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0529.v1

A Comparative Study on the Performance of Security Mechanisms in Internet of Things Devices

Moser José

Subject: Engineering, Other Keywords: Internet of Things; Performance; Raspberry Pi; Security; Devices; OpenSSL; Hash functions; Tests.

Online: 7 June 2023 (09:37:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0528.v1

Anxiety, Stress Perception and Coping Strategy Among Students with COVID-19 Exposure

Andrei Shpakou, Elżbieta Krajewska-Kułak, Mateusz Cybulski, Dorota Sokołowska, Małgorzata Andryszczyk, Ewa Kleszczewska, Yelena Loginovich, Jakub Owoc, Andrei V. Tarasov, Natalia A. Skoblina, Krystyna Kowalczuk

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: university students; anxiety stress perception; coping strategies; pandemic; COVID-19 patients

Online: 7 June 2023 (09:35:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0526.v1

Effects of Forest Fragmentation on Connectivity and Genetic Diversity in an Endemic and an Invasive Rodent in Northwestern Madagascar

Malcolm S. Ramsay, Gabriele Sgarlata, Christopher D. Barratt, Jordi Salmona, Bertrand Andriatsitohaina, Frederik Kiene, Sophie Manzi, Miarisoa L. Ramilison, Romule Rakotondravony, Lounés Chikhi, Shawn M. Lehman, Ute Radespiel

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Dispersal; Connectivity; Movement; Conservation Genomics; Madagascar; Habitat Loss and Fragmentation; Rodents

Online: 7 June 2023 (09:30:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0527.v1

XEN®-63 Compared to XEN®-45 Gel Stents to Reduce Intraocular Pressure in Glaucoma

Charlotte Evers, Daniel Böhringer, Sara Kallee, Philip Keye, Heiko Philippin, Timothy Piotrowski, Thomas Reinhard, Jan Lübke

Subject: Medicine And Pharmacology, Ophthalmology Keywords: XEN®-63 gel stent; glaucoma; bleb revision

Online: 7 June 2023 (09:29:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0524.v1

A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC Cables in Fires. IV: The Impact of Acid Scavengers at High Temperatures on Flame Retardance and Smoke Emission

Gianluca Sarti, Iacopo Bassi, Francesca Delchiaro, Claudia Bandinelli, Laura Mazzocchetti, Elisabetta Salatelli

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: PVC; Cables; smoke acidity; acid scavengers

Online: 7 June 2023 (09:22:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0523.v1

Influence of Frustration Effects on the Critical Current of DC SQUID

Iman Askerzade

Subject: Physical Sciences, Condensed Matter Physics Keywords: DC SQUID; frustration; critical current

Online: 7 June 2023 (09:21:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0522.v1

Recent Mechanistic Understanding of Fischer-Tropsch Synthesis on Fe-Carbide

Jiachun Chai, Jidong Jiang, Yan Gong, Peng Wu, Annan Wang, Xuebing Zhang, Tao Wang, Xiangkun Meng, Quan Lin, Yijun Lv, Zhuowu Men, Peng Wang

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Fischer-Tropsch synthesis; Fe-carbide; Mechanism; Synthesis gas; Fe carburization

Online: 7 June 2023 (08:58:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0521.v1

Platelet-Rich Plasma Power Mix gel (ppm) - An Orthobiologic Optimization Protocol Rich in Growth Factors and Fibrin

José Fábio Santos Duarte Lana, Joseph Purita, Peter Albert Everts, Palmerindo Mendonça Neto, Daniel de Moraes Ferreira Jorge, Tomas Mosaner, Lucas Furtado Da Fonseca, Madhan Jeyaraman, Gabriel Ohana Marques Azzini, Stephany Cares Huber, Gabriel Silva Santos

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: platelet-rich plasma; platelet-rich fibrin; hyaluronic acid; orthobiologics; osteoarthritis; regenerative medicine

Online: 7 June 2023 (08:54:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0520.v1

Convergence Analysis of Phase-Scheduled-Command FXLMS Algorithm with the Phase Error

Yushuai Wang, Feng Liu, Zhenrong Fu, Lianxin Yang, Pengfei Wang

Subject: Physical Sciences, Acoustics Keywords: active noise control; phase-scheduled-command FXLMS; active sound profiling; phase error.

Online: 7 June 2023 (08:52:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0519.v1

How to Influence Privacy Behavior Using Cognitive Theory and Respective Determinant Factors

Paspatis Ioannis, Tsohou Aggeliki

Subject: Computer Science And Mathematics, Computer Science Keywords: privacy behavior factors; privacy behavior; cognitive theory; health belief model

Online: 7 June 2023 (08:46:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0518.v1

Factors Associated with Depression, Anxiety and Somatic Symptoms Among International Salespeople in the Medical Device Industry: A Cross-sectional Study in China

Beibei Mao, Penkarn Kanjanarat, Tinakon Wongpakaran, Unchalee Permsuwan, Ronald O'Donnell

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety; somatic symptom; organizational factor; occupational factor; effort–reward imbalance; health-promoting leadership; health climate; inner strength; perceived social support; international salespeople; medical device industry

Online: 7 June 2023 (08:42:51 CEST)

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Background: Physical and mental health of corporate employees is equally important, especially in international salespeople in the in vitro diagnostic (IVD) medical device industry. The rapid growth of the IVD market is driven by the increasing prevalence of chronic and infectious diseases. This study aims to identify the association of socio-demographic, occupational, organizational, and psychosocial factors with mental health outcomes for depression, anxiety, and somatic symptoms in Chinese IVD international salespeople. Methods: The study was a cross-sectional survey of ISs in IVD companies officially registered in China. An online survey was designed to collect data through email contact with IVD companies and social media between August 2022 and March 2023. Measured factors included effort-reward imbalance (ERI), health-promoting leadership (HPL), health climate (HC), inner strength (IS), and perceived social support (PSS). Mental health outcomes assessed using the Core Symptom Index (CSI) were depression, anxiety, and somatic symptoms. Results: A total of 244 salespeople responded to the survey. CSI scores indicated that 18.4% (n = 45) and 10.2% (n = 25) of the respondents had symptoms of major depression and anxiety, respectively. ERI was positively correlated, while the IS and PSS were negatively correlated with major depression, anxiety, and somatic symptoms (p < .01). Health climate was negatively correlated with major depression (p < .05). Education background was associated with somatic symptoms (p < .05). ERI, IS, and gender were significant predictors of major depression, anxiety, and somatic symptoms (p < .05). Conclusion: The prevalence of depression and anxiety in China’s IVD international salespeople was considered low compared with prevalence in Chinese populations during COVID-19, but higher than those before the pandemic. Effort–reward imbalance, inner strength, and gender were significant factors in major depression, anxiety, and somatic symptoms among IVD international salespeople.

Preprint REVIEW | doi:10.20944/preprints202306.0517.v1

Current Data and Future Perspectives on Patients with Atrial Fibrillation and Cancer

Leonardo De Luca, Irma Bisceglia, Massimiliano Camilli, Maria Laura Canali, Raffaella Mistrulli, Federico Andreoli, Guido Giacalone, Domenico Gabrielli

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; cancer; direct oral anticoagulants

Online: 7 June 2023 (08:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0516.v1

Effect of Whey Protein Isolate (WPI)–Pectin Ratio on Phenolic Content Stability of Propolis Microcapsules

Nandi Sukri, Dela Sofia Annisa, Mohamad Djali, Yana Cahyana, Mahani Mahani, Syamsul Huda

Subject: Biology And Life Sciences, Food Science And Technology Keywords: WPI; pectin; coacervation; microcapsules; propolis

Online: 7 June 2023 (08:34:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0515.v1

Cryopreservation of Ovarian and Testicular Tissue and the Influence on Epigenetic Pattern

Tom Trapphoff, Stefan Dieterle

Subject: Biology And Life Sciences, Life Sciences Keywords: epigenetic; genomic imprinting; ovarian tissue cryopreservation; testicular tissue cryopreservation; Medically Assisted Reproduction

Online: 7 June 2023 (08:32:11 CEST)

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Ovarian tissue cryopreservation (OTC) or testicular tissue cryopreservation (TTC) are effective and often the only options for fertility preservation in female or male patients due to oncological, medical, or social aspects. While TTC and resumption of spermatogenesis, either in vivo or in vitro, has still be considered an experimental approach in humans, OTC and autotransplantation has been applied increasingly to preserve fertility with more than 200 live births worldwide. However, the cryopreservation of reproductive cells followed by the resumption of gametogenesis, either in vivo or in vitro, may interfere with sensitive and highly regulated cellular processes. In particular, the epigenetic profile, which includes not just reversible modifications of the DNA itself but also post-translational histone modifications, small non-coding RNAs, gene expression and availability, and storage of related proteins or transcripts, have to be considered in this context. Due to complex reprogramming and maintenance mechanisms of the epigenome in germ cells, growing embryos, and offspring, OTC and TTC are carried out at very critical moments early in the life cycle. Given this background, the safety of OTC and TTC taking into account the epigenetic profile has to be clarified. Cryopreservation of mature germ cells (including Metaphase II oocytes and mature spermatozoa collected via ejaculation or more invasively after testicular biopsy) or embryos has been used successfully for many years in Medically Assisted Reproduction (MAR). However, tissue freezing followed by in vitro or in vivo gametogenesis has become more attractive in the past, while few human studies have analysed the epigenetic effects, with most data deriving from animal studies. In this review, we highlight the potential influence of the cryopreservation of immature germ cells and subsequent in vivo or in vitro growth and differentiation on the epigenetic profile in humans and animals.

Preprint ARTICLE | doi:10.20944/preprints202306.0514.v1

Performance Improvement of a Solar Assisted Absorption Cooling System Integrated with Latent Heat Thermal Energy Storage

Lana Migla, Raimonds Bogdanovics, Kristina Lebedeva

Subject: Engineering, Other Keywords: LHTES; PCM; solar energy; solar cooling system

Online: 7 June 2023 (08:29:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0512.v1

Metatranscriptome Analysis of Nasopharyngeal Swabs Demonstrated Unprecedented Species Diversity

Michaela Hyblova, Dominik Hadzega, Klaudia Babisova, Patrik Krumpolec, Andrej Gnip, Peter Sabaka, Stefan Lassan, Gabriel Minarik

Subject: Biology And Life Sciences, Virology Keywords: metatranscriptome; microbiome; SARS-CoV-2; virome

Online: 7 June 2023 (08:23:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0490.v1

Empirical Comparison of Higher-Order Mutation Testing and Data-Flow Testing of C# with the Aid of Genetic Algorithm

Eman H Abd-Elkawy, Rabie Ahmed

Subject: Computer Science And Mathematics, Computer Science Keywords: Data flow testing; higher-order mutation testing; “ProbSubsumes”; “ProbBetter”

Online: 7 June 2023 (08:22:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0485.v1

Smart Materials in Medical Gloves

Maria José Lovato, Luis J. del Valle, Jordi Puiggalí, Lourdes Franco

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: medical gloves; natural rubber; synthetic rubber; bio-filler; reinforcing filler; antimicrobial properties; smart materials

Online: 7 June 2023 (08:20:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0511.v1

On Invariant Vectors in the Presence of Electric and Magnetic Fields

Jean-Christophe Pain

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: symmetry; invariant vectors; Hermann-Bernoulli-Laplace-Runge-Lenz vector; Redmond invariant; dynamical symmetry; supergeneralized Runge-Lenz vector; Kustaanheimo-Stiefel transformation; charge-dyon system; MIC-Kepler problem

Online: 7 June 2023 (08:19:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0510.v1

Exploring the Key Characteristics and Theoretical Framework for Research on the Metaverse

Chuanxiang Song, Seong-Yoon Shin, Kwang-Seong Shin

Subject: Computer Science And Mathematics, Computer Science Keywords: Metaverse; Key Characteristics; Theoretical Framework; Digitalization of Assets; Governance by Law; Combination of Virtual and Real; Rule of Technological Association

Online: 7 June 2023 (08:17:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0509.v1

Effect of Carbon Dioxide Injection on Limestone Permeability Damage Induced by Alumina Nanoparticles for Enhanced Oil Recovery Applications

Ragheed Alali, Kazunori Abe, Khawaja Naweed Seddiqi, Hikari Fujii

Subject: Engineering, Energy And Fuel Technology Keywords: nanoparticles enhanced oil recovery; pH control; alumina nanoparticles; permeability damage; transportability and retention

Online: 7 June 2023 (08:12:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0478.v1

Leaping Forward or Crawling Backward? Efforts and Biases in Amphibian and Reptile Research on a Megadiverse Faunal Region in the Philippines

Sumaira S. Abdullah, Kier Celestial Dela Cruz, Lothy F. Casim, Angelo Rellama Agduma, Krizler Cejuela Tanalgo

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Amphibians; Conservation; Islands; Philippines; Priorities.

Online: 7 June 2023 (08:06:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0508.v1

Pathological Effects of SARS-CoV-19 Associated With Hematological Abnormalities

Mrs Shama, Asif Mahmood, Shahid Mehmood, Wen Zhang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: SARS-CoV-2; Hematology; COVID-19; Biomarkers

Online: 7 June 2023 (08:05:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0507.v1

Immune Microenvironment and PD-L1 Expression in Breast Cancer: A Review of Current Evidence and Prognostic Implications from Pathologist’s Perspective

Giuseppe Angelico, Giuseppe Broggi, Giordana Tinnirello, Lidia Puzzo, Giada Maria Vecchio, Lucia Salvatorelli, Lorenzo Memeo, Angela Santoro, Gaetano Magro, Rosario Caltabiano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; TILs; PD-L1; immunotherapy; chemotherapy, triple negative breast cancer; HER2; luminal breast cancer; CPS

Online: 7 June 2023 (08:04:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0475.v1

Effectiveness and Safety of Glucosamine in Osteoarthritis: A Literature Review

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Uyen Thi Thuc Che, Thanh Thi Thanh Ngo, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Osteoarthritis; Effectiveness; Safety; Glucosamine; systematic review

Online: 7 June 2023 (07:58:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0505.v1

A Free Space Material Measurement System

Renukka Sivakumar, Saidatul Norlyana Azemi, Lee Yengseng, Kok Yeow You, Ping Jack Soh

Subject: Engineering, Electrical And Electronic Engineering Keywords: material measurement techniques; dielectric properties; free space measurement systems.

Online: 7 June 2023 (07:53:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0506.v1

Microbiological quality of typical traditional yoghurt from Norther Uganda and Western Kenya

Betty A. Ogwaro, Hazel Gibson, Dave J. Hill, Elizabeth A. O'Gara

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Microbiological quality; traditional fermented African yoghurt; public health concern

Online: 7 June 2023 (07:52:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0504.v1

Effect of Nano-Y2O3 on the Microstructure and Properties of Fe-Cr-C-N-Al Surfacing Alloy

Xingyu Ai, Zhengjun Liu, Zongxuan Zou

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Fe-Cr-C; Surfacing alloys; Nanometer rare earth；Hardening phase；Abrasive wear

Online: 7 June 2023 (07:45:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0496.v1

Ce 0.8-2x Sm 0.2 Zrx Mgx O2-d, {x= 0.05, 0.1 &0.15} Promising Electrolyte Compounds With Remarkable Conductivities for Intermediate Solid Oxide Fuel Cells (It-SOFCs) Applications

Abdalla M Abdalla, Mohamed M Khairat Dawood, Abul k Azad, Juantakan Taweekun

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Solid oxide fuel cells; Biomass; Electrolyte; Conductivity

Online: 7 June 2023 (07:22:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0497.v1

Carbon Capture Using Porous Silica Materials

Sumedha M Amaraweera, Chamila A. Gunathilake, Oneesha H.P. Gunawardene, Rohan S. Dassanayake, Eun-Bum Cho, Yanhai Du

Subject: Chemistry And Materials Science, Nanotechnology Keywords: CO2 Capture Technologies; CO2 Adsorption; Porous Silica; Amine Functionalized Porous Silica; Decarbonization.

Online: 7 June 2023 (07:19:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0503.v1

Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities

Li Jiaxin, Yan Yachao, Chen Yingzhi, Fang Qinglin, Muhammad Irfan Hussain, And Wang Lu-Ning

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Curcumin; MOF; Sodium Alginate Hydrogel; Drug Release; Antibacterial Activity

Online: 7 June 2023 (07:17:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0502.v1

Total Bio-Based Material To Fight Cancer Through Antimicrobial Activity

Vincenzo Patamia, Chiara Zagni, Roberto Fiorenza, Sandro Dattilo, Paolo Maria Riccobene, Giuseppe Floresta, Antonio Rescifina

Subject: Chemistry And Materials Science, Biomaterials Keywords: resveratrol; curcumin; halloysite nanotubes; kojic acid; iron chelation, antibacterial.

Online: 7 June 2023 (07:15:16 CEST)

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Nowadays, there is evidence that bacteria can contribute to cancer formation and interfere with therapy by mediating its carcinogenesis and related infection. Moreover, it is acknowledged that microbial infections and antibiotic resistance represent severe economic and health risks to society. These facts have led to the developing of several new techniques for impeding crucial biological processes in microbial cells. One of these techniques centers on using metal-chelating agents, which can disrupt the microorganism's vital metal metabolism by obstructing metal uptake and bioavailability for critical reactions. Additionally, nanotechnology has made a wide range of nanomaterials available for possible uses in the antibacterial industry. This complex field is shaped by antimicrobial nanoparticles, also investigated as therapeutic and drug-delivery tools. Halloysite nanotubes (HNTs) are naturally occurring tubular clay nanomaterials consisting of aluminosilicate kaolin sheets rolled up several times. The aluminon and siloxane groups on the surface of HNTs facilitate the formation of hydrogen bonds with biomaterials on their surface. These properties make HNTs crucial in a wide range of applications, such as in environmental sciences, wastewater treatment, dye removal, nanoelectronics and nanocomposite fabrication, catalytic studies, coatings for glass or anti-corrosive coatings, cosmetics, flame retardants, stimulus-response, and in forensic sciences. This work aimed to produce an antibacterial material by combining the properties of halloysite nanotubes with the ability of kojic acid to chelate iron. Starting from kojic acid, a simple nucleophilic substitution involving the hydroxyl groups on the surface of the nanotubes was performed. The obtained material was characterized by IR and SEM, and its ability to chelate iron was evaluated. Finally, the capacity to load drugs such as resveratrol and curcumin was also evaluated by UV analysis. In this way, a new bio-based material that can be used as a drug carrier and antimicrobial was produced.

Preprint ARTICLE | doi:10.20944/preprints202306.0501.v1

MicroRNA miR-274-5p Controls Melanotic Mass Formation and Developmental Growth by Regulating the Found-in-Neurons-JNK Signaling Axis in Drosophila

Hee Kyung Kim, Chae Jeong Kim, Daegyu Jang, Do-Hwan Lim

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Drosophila; miR-274; melanotic mass; growth; JNK signaling; JAK/STAT signaling; found-in-neurons

Online: 7 June 2023 (07:12:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0500.v1

Thymol@activated Carbon Nanohybrid for Low-Density Polyeth-Ylene Based Active Packaging Films for Pork Fillets Shelf-Life Extension

Aris E. Giannakas, Vassilios K. Karabagias, Dimitrios Moschovas, Areti Leontiou, Ioannis K. Karabagias, Stavros Georgopoulos, Andreas Karydis-Messinis, Konstantinos Zaharioudakis, Nikolaos Andritsos, George Kehayias, Apostolos Avgeropoulos, Charalampos Proestos, Constantinos Ε Salmas

Subject: Chemistry And Materials Science, Nanotechnology Keywords: activated carbon; thymol; low-density polyethylene; active packaging; control release; kinetics; pork fillets; heme iron; shelf life

Online: 7 June 2023 (07:09:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0499.v1

An Introduction to the Evaluation of Perception Algorithms & LiDAR Point Clouds using a Copula-based Outlier Detector

Nuno Reis, José Machado da Silva, Miguel Velhote Correia

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: autonomous driving; perception algorithms; LiDAR; anomaly detection; COPOD

Online: 7 June 2023 (07:08:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0498.v1

Survivals of Bacteriophage T4 in Quasi-Pure Ionic Solutions

Seiko Hara, Isao Koike

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: infectivity; neutral solution; acidic solution; alkaline solution; deprotonation

Online: 7 June 2023 (07:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0488.v1

State Anxiety and Intertemporal Decision-Making: The Mediation Effect of Inhibition Control and the Moderation Effect of Trait Anxiety

Yuyang Xuan, Jiajia Jin, Yujia Yao, Biao Sang

Subject: Social Sciences, Psychology Keywords: state anxiety; trait anxiety; intertemporal decision-making; inhibitory control

Online: 7 June 2023 (05:50:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0487.v1

Cell Free DNA Extracted From Csf for Molecular Diagnosis of Pediatric Embryonal Brain Tumors

Mathieu Chicard, Yasmine Iddir, Julien Masliah Planchon, Valérie Combaret, Valéry Attignon, Alexandra Saint-Charles, Didier Frappaz, Cécile Conter, Kevin Beccaria, Pascale Varlet, Birgit Geoerger, Sylvain Baulande, Gaelle Pierron, Yassine Bouchoucha, François Doz, Olivier Delattre, Joshua Waterfall, Franck Bourdeaut, Gudrun Schleiermacher

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pediatric embryonal brain tumors, liquid biopsy, cell-free DNA, molecular diagnosis, nucleosome footprinting

Online: 7 June 2023 (05:48:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0495.v1

Corrosion Protection Mechanism Study of Nitrite Modified CaAl-LDH in Epoxy Coatings

Junhao Xue, Jingjing Wang, Yanhui Cao, Xinyue Zhang, LilI Zhang, Kaifeng Chen, Congshu Huang

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Layered double hydroxide; Epoxy coatings; Corrosion protection mechanism

Online: 7 June 2023 (05:46:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0494.v1

The Clinical and Pathological Characteristics of Neonatal Cholestasis; A Case of Hevi Pediatrics Teaching Hospital in Duhok Province, Iraq

Nizar B Yahya, Ali A Ramadhan

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Neonatal Cholestasis; Liver biopsy; Biliary atresia; triangular cord sing

Online: 7 June 2023 (05:46:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0493.v1

Experimental Validation and Calibration of the Galvin Model with Artificial Tight Sandstones with Controlled Fractures

Yuangui Zhang, Bangrang Di

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Artificial fractured tight stones; equivalent medium theories; rock physics; experimental validation; anisotropy

Online: 7 June 2023 (05:45:05 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202306.0492.v1

Systematic Model Complexity Reduction by Elimination of Irrelevant Layers in Convolutional Neural Networks

Krishna Chaitanya Gadepally, Sambandh Bhusan Dhal, Stavros Kalafatis, Kevin Nowka

Subject: Engineering, Electrical And Electronic Engineering Keywords: strongest activations; image complexity; convolution

Online: 7 June 2023 (05:42:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0491.v1

Further Explanation on the Excitation Mechanism of Stay Cable Vibration in Dry Conditions

Duy Thao Nguyen, Duy Hung Vo

Subject: Engineering, Civil Engineering Keywords: Dry-state galloping; excitation mechanism; Karman vortex; low-frequency-vortices; shedding correlation; along-wind component; vertical-wind component

Online: 7 June 2023 (05:33:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0489.v1

Development and Design of an Optical-Electronic System of Fiber-Optic Sensors Based on Inclined Fiber Bragg Gratings

Aliya Kalizhanova, Ainur Kozbakova, Waldemar Wojcik, Murat Kunelbayev, Zhalau Aitkulov

Subject: Engineering, Telecommunications Keywords: fiber-optic sensor; optoelectronic system; light source controller; optical power detector.

Online: 7 June 2023 (05:19:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0486.v1

A Flexible and Transparent PtNP/Swcnt/Pet Electrochemical Sensor for Nonenzymatic Detection of Hydrogen Peroxide Released From Living Cells With Real-time Monitoring Capability

Da Eun Oh, Chang-Seuk Lee, Tae Wan Kim, Seob Jeon, Tae Hyun Kim

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Electrochemical sensing; flexible sensor; hydrogen peroxide (H2O2); platinum nanoparticles; single-walled carbon nanotube (SWCNT) network

Online: 7 June 2023 (04:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0484.v1

Promotion Effect of Agricultural Production Trusteeship on High-quality Production of Grain——Evidence from the Perspective of Farm Households

Xiaoyan Sun, Youchao Wang, Fengying Zhu, Xiaoyu Liu, Jianxu Liu, Songsak Sriboonchitta

Subject: Business, Economics And Management, Economics Keywords: agricultural production trusteeship; high-quality production of grain; propensity score matching

Online: 7 June 2023 (04:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0483.v1

Transcriptomic Analysis of Dehydration Rate of Mature Rice (Oryza sativa) Seeds

Zhongqi Liu, Haiqing Zhang, Jiwai He, Jinxin Gui, Yuntao Yan

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Rice seeds; dehydration rate; RNA-seq; DEGs

Online: 7 June 2023 (03:54:11 CEST)

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The transcriptomic analysis of the dehydration rate of mature rice seeds was conducted to explore candidate genes related to the dehydration rate and provide a theoretical basis for breeding and utilization. In this study, we selected Baghlani Nangarhar, an extremely fast dehydration material, and Saturn, a slow dehydration material, based on the results of the previous studies of screening of 165 germplasm materials for dehydration rate phenotypes. Fast dehydration experiment on these two types of seeds was conducted. Four comparative groups were set up under control and dehydration conditions. The differentially expressed genes (DEGs) were quantified by transcriptome sequencing and quantitative real-time PCR (qRT-PCR). GO and KEGG analyses were carried out. The results showed that in Baghlani Nangarhar, 53 DEGs were screened, of which 33 were up-regulated and 20 were down-regulated. Similarly, in Saturn, 25 DEGs were screened, of which 19 were up-regulated and 6 down-regulated. The results of the GO analysis showed that the sites of action of the differentially expressed genes enriched in the fast dehydration modes were concentrated in the cytoplasm, internal components of the membrane and nucleosomes. They play regulatory roles in catalysis, binding, translocation, transcription, protein folding, degradation and replication. They are involved in adaptive responses to adverse external environments such as reactive oxygen species and high temperature. The KEGG analysis showed that the main metabolic pathways enriched are protein processing in the endoplasmic reticulum, amino acid biosynthesis, and oxidative phosphorylation. The key differentially expressed genes and the most important metabolic pathways in the rapidly and slowly dehydrated materials obtained in this study were protein processing in the endoplasmic reticulum and oxidative phosphorylation metabolism, which are presumed to have important regulatory roles in stress/defense, energy metabolism, protein synthesis/folding, and signal transduction during dehydration and drying of mature seeds. The results of this study could potentially provide a valuable reference for further research on the genes and metabolic pathways related to the dehydration rate of mature rice seeds and provide theoretical guidance for the selection and breeding of new rice germplasm that can be rapidly dehydrated at the mature stage.

Preprint ARTICLE | doi:10.20944/preprints202306.0482.v1

A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice

Natalia E Cortez, Suraj Pathak, Cecilia Rodriguez Lanzi, Brian Hong, Rasheed O Sule, Ryman Crone, Fangyi Wang, Shuai Chen, Aldrin Gomes, Keith Baar, Gerardo Guillermo Mackenzie

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cachexia; pancreatic cancer; ketogenic diet; gemcitabine; cancer-associated cachexia

Online: 7 June 2023 (03:53:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0481.v1

Transmission of Rubella and Risk of Congenital Rubella Syndrome (Crs) in Pregnant Women during Prenatal Consultation at the Sino – Gabonese Friendship Hospital in Franceville

Nieguitsila Adelaïde, Cedric Obiang Sima, Thiéry Ndong Mba, Kervaly Pierre Bithegue Mba, Ulrich Nzamba, Hilaire Moundounga Kenguele, Arnaud Brice Pambo Pambo, Cyrille Cyrille Bisseye, Patrick Mickala

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Transmission; Rubella; Pregnant women; Friendship Sino-Gabonese Hospital; Franceville; Gabon

Online: 7 June 2023 (03:52:24 CEST)

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Objectives: Pregnant women represent a population category at high risk of severe rubella infection, capable of adversely affecting their fetus. This study was conducted to determine the seroprevalence of anti-rubella antibodies in pregnant women seen in prenatal consultations at the Sino-Gabonese Friendship Hospital in Franceville Patients and Methods: A prospective, cross-sectional study was conducted at the Sino-Gabonese Friendship Hospital in Franceville, from April 3 to July 27, 2023. Using a structured and pre-established questionnaire, sociodemographic and obstetrical characteristics were obtained... Three milliliters of blood were collected from participants to measure rubella-specific IgG antibody levels using the OnSite Rapid Test Rubella IgG/IgM COMBO lateral flow immunochromatographic assay. Results were considered significant at p≤0.05. Results: The study included 107 pregnant women seen in prenatal consultations. With a mean age of 27.9±7.1 years, anti-Rubella IgG antibodies were found in 87 pregnant women, indicating an overall seroprevalence of 81.30% (95% CI: [0.72 - 0.87). Of these, 6.9% (n = 6) of the women were serum anti-Rubivirus IgM carriers. In univariate analysis, it was indicated that pregnant women in the study aged between 21-30 years (OR =0.33; 95% CI: [0.12-0.9] p=0.0027), student (OR =6.35; 95% CI: [1.39-29.09] p=0.001), or without professional status (OR =0.05; 95% CI: [0.01- 0.27] p<0.001), high school education (OR =8.24; 95% CI: [2.83-23.96] p<0.001), single (OR =0.3; 95% CI: [0.11-0.85] p=0.0021) or cohabiting OR =3.91; 95% CI: [1.21-12.64] p=0.0017) Residing in an urban area (OR =49; 95% CI: [1.43-16.75] p=0.006), in the first trimester of their pregnancy (OR = 0.29; 95% CI: [0.09-0.94] p= 0.033), with a history of spontaneous abortion (OR = 0.09; 95% CI: [1.04; 11.30] p= 0. 037), and unvaccinated (OR = 0.13; 95% CI: [0.05; 0.13] p<0.000), had an elevated risk of Rubella, After adjusting for risk factors by logistic regression, residence in a rural area (ORA = 139.87 95% CI : [1.74 -11236.216] p=0.027),and no vaccination (ORA = 43.3 95% CI: [1.13 -1662.7] p= 0.043), were identified as the only significant risk factors for Rubella for the present study population Conclusion: The high rate of susceptibility to rubella among pregnant women in the present study indicates that any short-term vaccination strategy aimed at reducing the number of susceptible women of childbearing age is imperative

Preprint ARTICLE | doi:10.20944/preprints202306.0480.v1

Characterization of the Immune Landscapes of Malignant Pleural Effusions and Their Corresponding Primary Tumors from Patients with Breast Carcinoma or Lung Adenocarcinoma

Caddie Laberiano-Fernandez, Qiong Gan, Sophia Mei Wang, Auriole Tamegnon, Ignacio Wistuba, Esther Yoon, Sinchita Roy-Chowdhuri, Edwin Roger Parra

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Breast; lung; cancer; microenvironment; pleural effusion; immunofluorescence

Online: 7 June 2023 (03:49:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0479.v1

Advances in Analytical Techniques and Applications in Exploration, Mining, Extraction, and metallurgical Studies of Rare Earth Elements

V. Balaram

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: rare earth elements; ICP-MS; SHRIMP dating; LIBS analysis of REE; INAA; REE in Coal; Hyperspectral imaging; laser ablation; mineral analysis

Online: 7 June 2023 (03:49:17 CEST)

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The use of analytical techniques is important and critical in all areas of REE research such as exploration, mining, extraction, and metallurgical activities at different stages. At every stage of these activities, rock, ore, mineral, and other related materials have to be analysed for their REE contents in terms of elemental, isotopic, and mineralogical concentrations using different analytical techniques. Spectacular developments have taken place in the area of analytical instrumentations during the last four decades, with some of them having shrunk in size and become hand-held. Among laboratory-based techniques, F-AAS, GF-AAS, ICP-OES, and MP-AES have become very popular. Because of high sensitivity, less interference effects, and ease of use. ICP-MS techniques such as quadrupole-ICP-MS, ICP-MS/MS, ICP-TOF-MS, MH-ICP-MS, HR-ICP-MS, and MC-ICP-MS, with both solution nebulisation as well as direct solid analysis using laser ablation sample introduction methods, have become extremely popular for REE analysis. For direct analysis of solids INAA, XRF, and LIBS techniques besides LA-based ICP-MS techniques are being extensively utilised. LIBS technique in particular requires little to no sample preparation. TIMS, SIMS, and SHRIMP techniques are being used for isotopic as well as dating REE depots. Portable analytical techniques such as pXRF, pLIBS, and Raman spectrometers are able to do in situ analysis even in the field helping to take fast decisions during exploration studies. At present hyperspectral remote sensing techniques including hand-held, drone, and satellite-based techniques have become very popular in REE exploration studies because of their ability to cover larger areas in a limited time and thus became very cost-effective. Deployment of microanalytical devices/sensors mounted in remotely operated vehicles (ROV) is being successfully utilized in detecting REE-rich deposits in the deep oceans. Providing updated in-depth information on all these important aspects with suitable examples, especially from the point of view of REE research studies is the focal point of this review article.

Preprint ARTICLE | doi:10.20944/preprints202306.0477.v1

Epidemiological Changes in Orofacial Trauma between the Pre-Covid and COVID Periods: A Spanish Multicentre Comparative Study of Tertiary Referral Hospitals

Angela Sada-Urmeneta, Jose-Ignacio Salmeron-Escobar, Carlos Navarro-Cuéllar, Eduardo Olavarria, Gregorio Sanchez-Aniceto, Sonia Herrero-Alvarez, Oscar De la Sen-Corcuera, Anna-Maria Simon-Flores, Fernando Almeida, Iñigo Aragon-Niño, Jose-Luis Del Castillo, Dafne Gascon, Marc Agea, Manuel Tousidonis

Subject: Medicine And Pharmacology, Surgery Keywords: SARS-CoV-2; COVID-19; orofacial trauma; maxillofacial trauma; epidemiology; public health

Online: 7 June 2023 (03:35:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0476.v1

Diurnal Variation of and Optimal Time To Measure Holter-Based Late Potentials To Predict Lethal Arrhythmia After Myocardial In-Farction

Kenichi Hashimoto, Naomi Harada, Motohiro Kimata, Yusuke Kawamura, Naoya Fujita, Akinori Sekizawa, Yosuke Ono, Yasuhiro Obuchi, Tadateru Takayama, Yuji Kasamaki, Yuji Tanaka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Late potentials; signal-averaged electrocardiogrhy; heart rate variability; fatal arrhyrthmia; sudden cardiac death

Online: 7 June 2023 (03:30:57 CEST)

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Abstract: Background and Objectives: Holter-based late potentials (LPs) are useful for predicting lethal arrhythmias in organic cardiac diseases. Although Holter-based LPs exhibit diurnal varia-tion, no studies have evaluated the optimal timing of LP measurement over 24 h for predicting lethal arrhythmia that leads to sudden cardiac death. Thus, this study aimed to validate the most effective timing for Holter-based LP testing and to explore factors influencing diurnal variability of LP parameters. Materials and Methods: We retrospectively analyzed 126 patients with post-myocardial infarction (MI) status and 60 control participants who underwent high-resolution Holter electrocardiography. Among the 126 post-MI patients, 23 developed sustained ventricular tachycardia (VT) (the MI-VT group), while 103 did not (the MI-non-VT group) during the obser-vation period. Holter-based LPs were measured at 0:00, 4:00, 8:00, 12:00, 16:00, and 20:00, and heart rate variability analysis was simultaneously performed to investigate factors influencing diurnal variability of LP parameters. Results: Holter-based LP parameters showed diurnal variation with significant deterioration at night and improvement during the day. Assessment at the time with the longest duration of low-amplitude signals <40 μV in the filtered QRS complex terminus (LAS40) gave the highest receiver operating characteristics curve (area under the curve, 0.659) and the highest odds ratio (3.75; 95% confidence interval, 1.45–9.71; p=0.006) for predicting VT. In the multiple regression analysis, heart rate and noise were significant factors affecting LP parameters in the MI-VT and control groups. In the non-VT group, LP parameters were significantly influenced by noise and parasympathetic heart rate variability parameters such as logPNN50. Conclusions: For Holter-based LP measurements, test accuracy was higher when LP was measured at the time of the highest or worst value of LAS40. Changes in autonomic nervous system activity, including heart rate and noise levels, were factors influencing diurnal variability.

Preprint REVIEW | doi:10.20944/preprints202306.0474.v1

Endometriosis, Oocyte and Embryo Quality

Sania Latif, Ertan Saridogan

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Endometriosis; in vitro fertilization; oocytes; embryonic structures

Online: 7 June 2023 (03:25:39 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202306.0473.v1

Effects of COVID-19 infection in healthy subjects on cardiac function and biomarker of oxygen transport, blood coagulation and inflammation

Nadezhda G. Gumanova, Alexander Gorshkov, Natalya L Bogdanova, Andrei I Korolev

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; echocardiography; left ventricular mass index; the ratio between the E and A waves; deceleration time of early mitral inflow; biomarkers

Online: 7 June 2023 (03:22:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0472.v1

From the Discovery of Targets to Delivery Systems: How to Decipher and Improve the Metallodrugs Actions at Molecular Level

Ilaria Iacobucci, Sara La Manna, Irene Cipollone, Monaco Vittoria, Luisa Canè, Flora Cozzolino

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: metallodrugs; medicinal chemistry; chemoproteomics; thermal proteome profiling; pro-metallodrugs; delivery systems; nanoparticles

Online: 7 June 2023 (03:11:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0471.v1

Determinants of Task Difficulty in Route Following Tasks: An Experimental Study on Human Spatial Navigation

Otmar Bock, Ju-Yi Huang

Subject: Social Sciences, Cognitive Science Keywords: wayfinding; navigation; decision making; spatial orientation; task demand

Online: 7 June 2023 (03:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0469.v1

Dynamical Analysis of an Age-Structured Sveir Model With Imperfect Vaccine

Yanshu Wang, Hailiang Zhang

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: SVEIR model; latent age; imperfect vaccine; Lyapunov functions; stability

Online: 7 June 2023 (02:32:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0470.v1

Comparative Analysis of Cardiac Resynchronisation Therapy Upgrades in Patients with Icd And Pacemakers with Chronic Right Ventricle Pacing-Induced Cardiomyopathy

Arsalan Farhangee, Marke Davies, Ion Mindrila, Robyn Meyrick, Katie Gaughan, David Morgan, Ben Sieniewicz

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Cardiac resynchronisation therapy; Pacemaker; implantable cardioverter defibrillator; Cardiomyopathy

Online: 7 June 2023 (02:32:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0468.v1

Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer – Implications for the Fertility-sparing Process: Clinical, Biological and Legal Aspects

Roberto Piergentili, Giuseppe Gullo, Giuseppe Basile, Caterina Gulia, Alessandro Porrello, Gaspare Cucinella, Enrico Marinelli, Simona Zaami

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Endometrial cancer (EC); assisted reproduction techniques (ART); miR-based; molecular evaluation; ethical and legal/regulatory implications

Online: 6 June 2023 (14:54:47 CEST)

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