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Preprint ARTICLE | doi:10.20944/preprints202309.1983.v1

Control Problem Related to a 2D Parabolic-Elliptic Chemo-Repulsion System with Nonlinear Production

Exequiel Mallea-Zepeda, Luis Medina

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: Chemo-repulsion system; optimal control problem; optimality conditions.

Online: 29 September 2023 (16:25:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2120.v1

Caboxamycin with Antiviral Activity in CVB3-Induced Myocarditis Mouse Model

Hong-Gi Kim, Prima F. Hillman, You-Jeung Lee, Ha-Eun Jeon, Byung-Kwan Lim, Sang-Jip Nam

Subject: Medicinal Chemistry, Chemistry And Materials Science Keywords: coxsackievirus B3; myocarditis; apoptosis; caboxamycin; Streptomyces sp. SC0774

Online: 29 September 2023 (15:42:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2119.v1

Ocular Neuromodulation as a Novel Treatment for Retinitis Pigmentosa: Identifying Rod Responders and Predictors of Visual Improvement

Ismail M Musallam

Subject: Ophthalmology, Medicine And Pharmacology Keywords: Retinitis pimentosa; Ocular neuromodulation; Ophthalmic nerve stimulation; Ascorbic acid; night blindness; Rod responders

Online: 29 September 2023 (15:18:42 CEST)

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Starvation of photoreceptors induced by reduced dysregulated ocular blood flow (OBF) is proposed as a common pathway for pathogenesis of retinitis pigmentosa (RP). The current study evaluated the safety and efficacy of ophthalmic nerve stimulation (ONS) as an OBF neuromodulator, combined with ascorbic acid (AA) as a potent anti-oxidant in treatment of RP. Additionally, the initial characteristics of rod responders were identified. Forty participants with simple RP, were enrolled in a prospective open-label intervention. The severity of the disease was clinically graded into five stages. Patients with established diagnosis of RP; aged ≥ 4 years, with BCVA ≥ 20/400 were included. All participants were daily treated with bilateral ONS sessions combined with systemic AA for two weeks. The primary efficiency endpoint was 6 months’ changes in scotopic vision as measured by a 10-items, 100 points, Low Luminance Questionnaire- (LLQ-10). The secondary efficiency points included best corrected visual acuity (BCVA) and contrast sensitivity (CS). Rod responders were defined by ≥ 25points increment of LLQ-10 score. The results showed that ONS combined with AA treatment significantly improved night vision, BCVA and CS in patients with RP. At 6-month visit, twenty-four (60%) patients were identified as rod responders and 16 (40%) patients were non-responders. The mean change in LLQ-10 score was (46.35 ±16.81) in rod responders versus (4.9 ± 7.6) in non-responders (P < 0.0001). A clinically significant improvement of BCVA (≥0.2 logMAR) and CS (≥0.3 log unit) were demonstrated in 44.4% and 56.1% of eyes of rod responders respectively. Collectively, this study sheds light on determinants of rod responsiveness which include patients’ age, duration of night blindness and the stage of RP. It also highlights two therapeutic scenarios; an early disease -modifying intervention that restore night vision and reverse the disease process and a late cone rescue intervention that improve/maintain central vision.

Preprint ARTICLE | doi:10.20944/preprints202309.2118.v1

Is Extereme Cytoreductive Surgery Beneficial To Survival In Malignant Peritoneal Mesothelioma?

Murat Can Mollaoğlu, Ufuk Karabacak, Meriç Emre Bostancı, Turan Eray Sever, Kürşat Karadayı

Subject: Surgery, Medicine And Pharmacology Keywords: cytoreductive surgery; extreme cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; malign peritoneal mesothelioma; peritoneal cancer index.

Online: 29 September 2023 (14:56:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2110.v1

Cryosurgery Harvested Veins as Potential Grafts: An Immunohistochemical Analysis of Venous Samples

Andrei Florin Parau, Amalia Raluca Ceaușu, Pușa Nela Gaje, Marius Raica

Subject: Surgery, Medicine And Pharmacology Keywords: proliferation rate; endothelium; varicose veins; cryosurgery

Online: 29 September 2023 (14:09:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2107.v1

Fastest Moroccan License Plate Recognition Using a Lightweight Modified YOLOv5 Model

Abdelhak Fadili, Mohamed El Aroussi, Rachid Saadane, Youssef Fakhri

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: License plate detection; deep learning; YOLOv5; ShuffleNet

Online: 29 September 2023 (14:07:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0207.v22

On Duality Principles and Related Convex Dual Formulations Suitable for Local Non-Convex Variational Optimization

Fabio Botelho

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: convex dual variational formulation; duality principle for non-convex local primal optimization; Ginzburg-Landau type equation

Online: 29 September 2023 (14:03:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2100.v1

Quantum Machine Learning Guided Image Synthesis

Geraci Joseph, Siddhant Jain, Harry E Ruda

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: quantum algorithms; quantum machine learning; generative ai; quantum generative ai; generative learning; diffusion ai

Online: 29 September 2023 (14:02:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1923.v2

The Impact of Antibiotic Prophylaxis in a Retrospective Cohort of Hospitalized Patients with COVID-19 Treated with the Combination of Steroids and Tocilizumab

Francisco Javier Membrillo de Novales, German Ramirez-Olivencia, Tatiana Mata Forte, María Isabel Zamora Cintas, María Simón Sacristán, María Sánchez de Castro, Miriam Estébanez Muñoz

Subject: Epidemiology And Infectious Diseases, Medicine And Pharmacology Keywords: COVID-19; Steroids; Tocilizumab; Prophylaxis; Ceftobiprole

Online: 29 September 2023 (14:00:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2017.v1

RC Electrical Modelling of Black Hole. New Method to Calculate the Amount of Dark Matter and the Rotation Speed Curves in Galaxies

Hector Gerardo Flores, Maria Isabel Gonçalves de Souza

Subject: Astronomy And Astrophysics, Physical Sciences Keywords: RLC electrical model; RC electrical model; cosmology; background radiation; Hubble’s law; Boltzmann´s constant; dark energy; dark matter; black hole; Big Bang and cosmic inflation.

Online: 29 September 2023 (13:28:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2111.v1

Qualitative Comparative Analysis of Medical and Epidemiological Data

Valerii Tsvetkov, Ivan Tokin

Subject: Other, Medicine And Pharmacology Keywords: qualitative comparative analysis; qualitative analysis; data mining; calibration; truth table; logical minimization; QMC; eQMC; CCubes

Online: 29 September 2023 (13:05:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2097.v1

Engineering a Computable Epiblast for in silico Modeling of Developmental Toxicity

Kaitlyn Barham, Richard Spencer, Nancy C. Baker, And Thomas B. B. Knudsen

Subject: Toxicology, Biology And Life Sciences Keywords: cellular dynamics; multicellular agent-based model; computer simulation; developmental toxicity.

Online: 29 September 2023 (12:02:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2103.v1

Developments in Genetics – a Better Management of Ovarian Cancer Patients

Ovidiu Virgil Maioru, Viorica Elena Radoi, Laurentiu Camil Bohîlțea, Madalin Codrut Coman, Anca Elena Eftenoiu, Andra Dan, Livia Mălina Burtavel, Iulian Andrei Hotinceanu, Emilia Maria Severin

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: Ovarian; Molecular; Genetics; Pathways; Diagnosis; Screening; Panel

Online: 29 September 2023 (12:00:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2095.v1

Resistance to Plant Parasites in Tomato Is Induced by Soil Enrichment with Specific Bacterial and Fungal Rhizosphere Microbiome

Sergio Molinari, Paola Leonetti

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: AMF; BCF; PGPR; plant immune system; priming; root microbiome; RKNs

Online: 29 September 2023 (11:57:23 CEST)

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Commercial formulates of beneficial microbes have been used to enrich the rhizosphere microbiome of tomato plants grown in pots located in a glasshouse. These plants have been subjected to attacks by soil-borne parasites, such as root-knot nematodes (RKNs), and herbivores, such as the miner insect Tuta absoluta. The development of both parasites and the symptoms of their parasitism were restricted in these plants with respect to plants left untreated. A mixture, named in the text as Myco, containing plant growth promoting rhizobacteria (PGPR), opportunistic biocontrol fungi (BCF), and arbuscular mycorrhizal fungi (AMF) was more effective in limiting pest damages than a formulate containing the sole AMF (Ozor). Therefore, Myco-treated plants inoculated with RKNs were taken as a model to further study which biocontrol agent (BCA) was specifically responsible of plant immunization and the molecular pathways exploited to achieve such an immunization. The PGPR contained in Myco were not able to reduce nematode infection, rather, they worsened symptoms on plants, compared with those observed on untreated plants. When plants were treated with suspensions of Bacillus subtilis at concentrations similar to those provided with Myco and then inoculated with RKNs, infection was actually more severe than that on untreated plants. Therefore, it was argued that both BCF and AMFwere the microorganisms that, colonizing roots, synergistically stimulate plant immune system against RKNs. Beneficial fungi lowered the activities of the defense supporting enzymes endochitinases and β-1,3-glucanase to be able to colonize the roots. However, as early as three days after nematode inoculation, these enzyme activities, and the expression of the encoding pathogenesis related genes (PR-2, PR-3) were found to be enhanced in roots with respect to not inoculated plants, thus indicating that plants had been primed against RKNs. Addition of paclobutrazol, which reduced salicylic acid (SA) levels in cells, and of diphenyliodonium chloride, which inhibits superoxides generation, completely abolished the repressive effect of Myco on nematode infection and presumably plant immune reaction. Inhibitors of copper enzymes and of the alternative cyanide-resistant respiration did not significantly alter resistance induction by Myco. When Myco-treated plants were subjected to a moderate water stress and inoculated with nematodes, they retained numbers of developed individuals in the roots similar to those present in regularly watered plants, in contrast to what occurred in roots of untreated stressed plants that hosted very few individuals because of poor nutrient availability.

Preprint ARTICLE | doi:10.20944/preprints202309.2101.v1

Optimizing Foreign Language Learning in Virtual Reality: A Comprehensive Theoretical Framework Based on Constructivism and Cognitive Load Theory (VR-CCL)

Chuanxiang Song, Seong-Yoon Shin, Kwang-Seong Shin

Subject: Computer Science, Computer Science And Mathematics Keywords: Virtual Reality; Foreign Language Learning; Constructivism; Cognitive Load Theory; VR-CCL Framework; Technology-Assisted Learning

Online: 29 September 2023 (11:54:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2106.v1

Protoplasmic Perivascular Astrocytes Play a Crucial Role in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

Melvin R. Hayden

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: BBB; endothelial glycocalyx; enlarged perivascular spaces; metabolic syndrome; neuroinflammation; neurovascular unit; obesity; perivascular spaces; perivascular unit; type 2 diabetes mellitus

Online: 29 September 2023 (11:14:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2104.v1

A New Species of Hemilauxania Hennig (Lauxaniidae) from the Lower Eocene Oise Amber—The Oldest Record of Schizophora (Diptera)?

Jindřich Roháček, Christel Hoffeins

Subject: Insect Science, Biology And Life Sciences Keywords: extinct lauxaniid flies; age of Acalyptratae; Paleogene

Online: 29 September 2023 (10:57:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2083.v1

A Gastroenterologist’s Guide to Care Transitions in Cystic Fibrosis from Pediatrics to Adult Care

Dhiren Patel, Michelle Baliss, Pavithra Saikumar, Laith Numan, Jeffrey Teckman, Christine Hachem

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: Cystic Fibrosis; transition of care; pediatrics; Gastrointestinal care; Pancreatic enzyme; highly effective modulators

Online: 29 September 2023 (10:43:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2082.v1

Failure of Non-invasive Respiratory Support in Patients with SARS-Cov-2 with the Different Therapies

Juan Javier García-Fernández, José Andrés Sánchez-Nicolás, Sonia Galicia-Puyol, Isabel Gil-Rosa, Juan Jose Guerras Conesa, Enrique Bernal-Morell, César Cinesi-Gómez

Subject: Internal Medicine, Medicine And Pharmacology Keywords: Non-invasive respiratory support 1; SARS-CoV-2 2; Hospitalization 3; CPAP 4; HFNO 5; Bilevel 6

Online: 29 September 2023 (10:41:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2093.v1

The Hidden Dangers of Excess Folate, Uncovering the Molecular Mechanisms

ALI M FARDOUS, Ahmad R Heydari

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Unmetabolized folic acid (UMFA); folic acid; one-carbon cycle; Methylation; epigenetic; carcinogenesis; aging; neurodevelopment; embryogenesis; folate

Online: 29 September 2023 (10:39:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2098.v1

Effectiveness and Applications of an Antimicrobial Biopolymer Compatible with Additive Manufacturing

Jorge M. Zuniga, Alex Evenson, Andrew D'Ovidio

Subject: Clinical Medicine, Medicine And Pharmacology Keywords: Additive manufacturing; antimicrobial materials; biopolymers; copper composite additives; medical devices

Online: 29 September 2023 (10:36:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2074.v1

Prevalence of RAF1 Aberrations in Metastatic Cancer Patients: A Real World Data

Sung Hee Lim, Jaeyun Jung, Jung Young Hong, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Kyoung-Mee Kim, Jeeyun Lee

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: RAF1 aberration; amplification; fusion; single nucleotide variants; RAF inhibitor

Online: 29 September 2023 (10:33:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2102.v1

Aerodynamic Performance of Wind Turbines Operating under Hazard Environmental Conditions: A Review

Eleni Douvi, Dimitra Douvi

Subject: Mechanical Engineering, Engineering Keywords: aerodynamic performance; wind turbine; icing; rainfall; hailstorm; dust; sand; insects; humidity; sea spray

Online: 29 September 2023 (10:30:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2066.v1

Phytochemical Screening of Genus Primula Species Growing in Georgia and Study of Their Antioxidant and Anti-inflammatory Potentials

Nino Sukhishvili, Thierry Franck, Ange Mouithys-Mickalad, Michel Frédérich, Karen Mulkijanyan, Charlotte Sandersen, Didier Serteyn, Lasha Mskhiladze

Subject: Plant Sciences, Biology And Life Sciences Keywords: Primula macrocalyx; Primula woronowii; Primula saguramica; Extraction; Stoichiometric Anticatalytic; Antioxidant; ABTS; DPPH; Neutrophils; Myeloperoxidase; Reactive oxygen species

Online: 29 September 2023 (10:28:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2075.v1

Innovative Solution or Cause for Concern? The Use of Continuous Glucose Monitors in People Not Living with Diabetes: A Narrative Review.

Zhanna Oganesova, John Pemberton, Adrian Brown

Subject: Other, Public Health And Healthcare Keywords: Continuous Glucose Monitor; People not living with diabetes; Regulations

Online: 29 September 2023 (10:22:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2089.v1

From Grain to Gain: Revolutionizing Maize Nutrition

Shreya Mandal, Vikas Kumar Singh, Divya Chaudhary, Arshdeep Kaur, Rahul Kumar, Anjali Panwar, Anjali Ojre, Ramesh Kumar Singh, Prashant Kaushik

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: maize; global nutrition; macronutrients; biofortification; genetic modification; maize processing

Online: 29 September 2023 (10:15:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2099.v1

Trust in Artificial Intelligence: Modelling Human Operators’ Decision-Making in Highly Dangerous Situations

Alexander L. Venger, Victor M. Dozortsev

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: human operator; trust in artificial intelligence; recommender systems; intelligent decision-making systems; admissible probability of disaster; and equipment predictive analytics

Online: 29 September 2023 (10:03:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2088.v1

A Comprehensive Examination of Vegan Lifestyle in Italy

Annachiara Stenico, Diana Zarantonello, Michael Kob

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: plant-based diet; vegan diet; healthy habits and eating trends; dietary patterns

Online: 29 September 2023 (09:53:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2096.v1

An Emulsified Liquid Paraffin Formulation for Functional Constipation: Pharmacokinetics of Vitamins K1, D3, A, and E in a Rat Model

Federico Perez Agudo, Janne Mannila, Valtteri Rinne, Elina Kallio, Ville Moilanen

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: constipation; laxatives; liquid paraffin; fat-soluble vitamins; vitamin A; vitamin E; vitamin D3; vitamin K1; pharmacokinetics; experimental model.

Online: 29 September 2023 (09:52:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1935.v1

Nanotechnology Devices for Glaucoma Surgical Treatment: A Systematic Review

Francisco Serdoura Alves, Susana Duarte, Afonso Cabrita, Carolina Marques, Alexandra Oliveira, Mónica Machado, Gabriela Silva, Luis Abegão Pinto, Joana Tavares Ferreira, Quirina Ferreira

Subject: Ophthalmology, Medicine And Pharmacology Keywords: glaucoma drainage device; glaucoma surgery; valve; nanotechnology; nanoparticles; nanomedicine.

Online: 29 September 2023 (09:39:52 CEST)

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Purpose: Glaucoma is the second leading cause of blindness, however, it remains incurable even with the appropriate treatment. Intraocular pressure (IOP) reduction is currently the only proven method to decline glaucoma progression. When medical therapy fails, surgical treatment usually arises as the solution to a better IOP control. Nevertheless, its success is compromised by frequent post-operative complications, most of them due to excessive fibrous tissue formation during wound healing process. Nanotechnology devices for glaucoma surgery can improve post-operative IOP control and reduce undesirable fibrosis. This systematic review aims to summarize some advances of nanotechnology application to ophthalmology, giving an overview about the state of the art of the nanotechnology based glaucoma drainage devices. Methods: A literature search in the PubMed/Medline database was performed using the keywords: “glaucoma surgery”, “glaucoma drainage device”, “nanotechnology”, “nanoparticles”, “nanomedicine” and “valve”. Were included articles published until March 1, 2023. A first identification of relevant articles was done through the title and abstract’s information, and a second selection was done by full-text articles assessment. Seven articles were included in this systematic review. Results: Nanotechnology-based glaucoma drainage devices included in this review promise to overcome the challenges of glaucoma surgical treatment by allowing a more effective control over post-operative scarring, a noninvasive and customized control of aqueous humour (AH) drainage while achieving optimal IOP reduction through all phases of the post-operative period. Conclusion: Despite the decreased post-operative complications and apparently enhanced biocompatibility of nano-based drainage devices, further in vivo tests and human studies are needed to evaluate cytotoxicity and corroborate the biocompatibility and efficacy showed in the initial testing results of these devices.

Preprint REVIEW | doi:10.20944/preprints202309.2094.v1

The Rate of Entropy Production in Biophysical-Chemical Systems

J.M. Nieto-Villar, R. Mansilla

Subject: Biophysics, Physical Sciences Keywords: nonequilibrium thermodynamics; entropy production rate; Lyapunov function; complexity; extremal principle; fractal dimension; biological phase transitions

Online: 29 September 2023 (09:36:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2091.v1

Assessing Functional Capacity in ME/CFS: A Patient Informed Questionnaire

Kristian Sommerfelt, Trude Schei, Katharine A Seton, Simon R Carding

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: ME/CFS; chronic fatigue syndrome; functional capacity; post exertional malaise; questionnaire; survey

Online: 29 September 2023 (09:21:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2084.v1

Host Genetic Background Effect on Body Weight Changes Influenced by Smad4 Knockout Using Collaborative Cross Mouse Population

Nayrouz Qahaz, Iqbal M LONE, Aya Ghnaim, Aya Khadeja, Osayd Zohud, Nadav Bennun, Aysar Nashef, Imad Abu El-Naaj, FUAD IRAQI

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: Collaborative cross (CC); Smad4 knock out; body weight gain; machine learning (ML); genotyping

Online: 29 September 2023 (08:44:37 CEST)

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Background: Obesity and its attendant conditions have become major health problems worldwide and is currently ranked as the fifth most common leading cause of death globally. Complex environmental and genetic factors are the cause of the current obesity epidemic. Diet, lifestyle, chemical exposures, and other confounding factors are difficult to manage in humans. The mice model is helpful in researching genetics BW gain because genetic and environmental risk factors can be controlled in mice. Studies in mouse strains with various genetic backgrounds and established genetic structures provide unparalleled opportunities to find and analyze trait-related genomic loci. In this study, we used the Collaborative Cross (CC), a large panel of recombinant inbred mouse strains, to present a predictive study using CC mice SMAD4 knockout profiles to understand and effectively identify predisposition to body weight gain. Materials and Methods: Male C57Bl / 6J Smad4+/- mice were mated with female mice from 10 different CC lines to create F1 mice (Smad4+/- x CC). Body weight (BW) was measured weekly until week 16, then monthly until the end (week 48). The heritability H2 of the assessed traits was estimated and presented. Comparative analysis of various machine learning algorithms for predicting the BW changes and genotype of mice was conducted. Results and conclusions: Our data showed that the body weight records of F1 mice with different CC lines differed between wildtype and mutant Smad4 mice during the experiment. Genetic background affects weight gain and some lines gained more weight in the presence of Smad4 knockout, while others gained less, but in general, the mutation caused overweight mice, except for a few lines. In both control and mutant groups, female %BW had a higher heritability H2 value than males. Additionally, both sexes with wildtype genotypes showed higher heritability values than the mutant group. Logistic Regression provides the most accurate mouse genotype predictions using machine learning. We plan to validate the proposed method on more CC lines and mice per line to expand machine learning for BW prediction.

Preprint ARTICLE | doi:10.20944/preprints202309.2087.v1

Socioeconomic Factors, Rocket Sirens, and PTSD: Insights from the Israel-Hamas Conflict

Yaakov Bayer

Subject: Sociology, Social Sciences Keywords: PTSD; armed conflicts; socioeconomic status

Online: 29 September 2023 (08:42:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2064.v1

Adversarial Attacks Can Deceive AI Systems, Leading to Misclassification or Incorrect Decisions

Petar Radanliev, Omar Santos

Subject: Security Systems, Computer Science And Mathematics Keywords: adversarial attacks; artificial intelligence; machine learning; defense mechanisms; system integrity; model vulnerabilities; advanced attack techniques; Fast Gradient Sign Method (FGSM); Carlini and Wagner Attack (C&W); targeted attacks; non-targeted attacks; blackbox attacks

Online: 29 September 2023 (08:42:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.2040.v1

Scalp Reconstruction Using O-Z Flap: An Alternative Approach for Melanoma Patients with Surgical Challenges

Dongnyeok Jeon

Subject: Surgery, Medicine And Pharmacology Keywords: O-Z flap; scalp reconstruction; malignant melanoma; skin cancer

Online: 29 September 2023 (08:41:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2065.v1

Assessment of Joinability in Additive Manufactured Interlocking Structure with Experiment and Simulation

Se-hun Kwon, Hak-Sung Lee, Ye-rim Kim, Eun-ah Kim, Joon Phil Choi, Taeho Ha, Soonho Won, Jong Bae Jeon

Subject: Metallurgy And Metallurgical Engineering, Engineering Keywords: additive manufacturing; interlocking structure; Design for Additive Manufacturing (DfAM); Netfabb Local Simulation

Online: 29 September 2023 (08:39:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2086.v1

Photon Interactions in Gravity and Antigravity: Conservation, Dark Energy, and Redshift Effects

Soumendra Nath Thakur, Deep Bhattacharjee, Onwuka Frederick

Subject: Astronomy And Astrophysics, Physical Sciences Keywords: Photon, Gravity, Antigravity, Dark Energy, Redshift

Online: 29 September 2023 (08:37:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2027.v1

Fault Recovery Methods for a Converged System Comprised of Power Grids, Transportation Networks and Information Networks

Geng Zhang, Chenxu Liu, Hao Jiang, Jiye Wang

Subject: Electrical And Electronic Engineering, Engineering Keywords: triple-network convergence; fault recovery; TD3 algorithm; DoS attack; resilience

Online: 29 September 2023 (08:35:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2043.v1

Snapshot of the Phylogenetic Relationships among Avian Pox-Viruses Circulating in Portugal between 2017 and 2023

Daniela Santos, Teresa Fagulha, Margarida Dias Duarte, Ana Duarte, Fernanda Ramos, Sílvia C Barros, Tiago Luís, Ana Margarida Henriques

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Avipoxvirus; molecular characterization; phylogenetic analysis; viral introduction; Portugal

Online: 29 September 2023 (08:32:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2037.v1

First Investigation of the Optimal Vaccination Timing for Nile Tilapia (Oreochromis niloticus) Larvae against Streptococcus agalactiae

Benchawan Kumwan, Anurak Bunnoy, Satid Chatchaiphan, Pattanapon Kayansamruaj, Ha Thanh Dong, Saengchan Senapin, Prapansak Srisapoome

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Nile tilapia; Oreochromis niloticus; Streptococcus agalactiae; formalin-killed vaccine; immunocompetence

Online: 29 September 2023 (08:29:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2042.v1

An Analysis of the Impact of Religious Affiliation and Strength of Religiosity on Sexual Health Practices of Sexually Active Female College Students

Emily Glazer, Emma Valdez, Justin A. DeBlauw, Stephen Ives

Subject: Primary Health Care, Public Health And Healthcare Keywords: Sexual health; contraceptives; religion; social determinants

Online: 29 September 2023 (08:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2036.v1

Pilocarpine-Induced Status Epilepticus in the Rat Hippocampus is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ and Collagen IV in Endothelial Cells and Pericytes of the Blood Brain Barrier

Grigorios Kyriatzis, Anne Bernard, Angélique Bôle, Michel Khrestchatisky, Lotfi Ferhat

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Blood brain barrier, Gliosis, Temporal lobe epilepsy, Inflammation, Epileptogenesis, Hippocampus, Endothelial cells, Pericytes, Basal membrane

Online: 29 September 2023 (08:26:25 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202309.2051.v1

The Underappreciated Role of Reproductively Lethal Mutations in the Evolution of Living Beings

Feng Qu, Khwannarin Khemsom, Camila Perdoncini Carvalho, Junping han

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Lethal mutation; reproductively lethal mutation; reproductive bottlenecking; evolution; natural selection; phenotype; asexual reproduction; sexual reproduction; virus; bacterium; plant; insect, animal; eusociality

Online: 29 September 2023 (08:24:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2035.v1

Machinery Prognostics and High-Dimensional Data Feature Extraction Based on A Transformer Self-Attention Transfer Network

Shilong Sun, Tengyi Peng, Haodong Huang

Subject: Mechanical Engineering, Engineering Keywords: Feature extraction; Prognostics; Self-attention transfer network; High-dimensional data

Online: 29 September 2023 (08:21:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2046.v1

Research on Secure State Estimation and Recovery Control for CPS under Stealthy Attacks

Biao Yang, Liang Xin, Zhiqiang Long

Subject: Control And Systems Engineering, Engineering Keywords: cyber-physical systems (CPSs); secure state estimation; recovery control; stealthy attacks; improved Kalman filter; internal model control (IMC)

Online: 29 September 2023 (08:20:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2085.v1

Unveiling the Strain Rate Sensitivity of G18NiCrMo3-6 Cast Steel in Tension/Compression Asymmetry

Barış Çetin, Emin Bayraktar, Ozgur Aslan

Subject: Mechanical Engineering, Engineering Keywords: strain rate sensitivity; G18NiCrMo3-6; cast iron plasticity

Online: 29 September 2023 (08:16:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2060.v1

Soft End Effector using Spring Roll Dielectric Elastomer Actuators

Hamish Lewis, Min Pan

Subject: Mechanical Engineering, Engineering Keywords: dielectric elastomer actuator; soft end effector; multiple degrees of freedom; modelling; artificial muscle

Online: 29 September 2023 (08:08:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2063.v1

Understanding the Knowledge, Attitudes, and Practices of Hand Hygiene, Wearing Mask, and Social Distancing among the Public Hospital and Polyclinic Nurses in Barbados Amid the COVID-19 Pandemic

Uma Gaur, Wendy Sealy, Ambadasu Bharatha, Natasha P. Sobers, Kandamaran Krishnamurthy, Michael H. Campbell, Cara Cumberbatch, Maia Drakes, Marielle Gibbs, Charisse Alexander, Heather Harewood, Peter Adams, Subir Gupta, Ali Davod Parsa, Russell Kabir, Md Anwarul Azim Majumder

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: COVID-19 pandemic; Nurses; Hand washing; Mask-wearing; Social distancing

Online: 29 September 2023 (08:06:30 CEST)

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Background: Nurses are essential members of the healthcare workforce and were among the first line carers for patients in community and hospital settings during the COVID-19 pandemic. As a result, they were at a heightened risk of contracting the disease, resulting in a significant number of reported deaths among them. Several preventive measures were adopted to contain the spread of this potentially lethal virus. This study aims to explore the knowledge, attitudes, and practices (KAP) of nurses regarding hand hygiene, mask wearing, and social distancing measures in healthcare settings in Barbados during the COVID-19 pandemic. Method: An online survey of nurses working in public hospitals and polyclinics (public primary care clinics) of Barbados from December 2020 to July 2021, was conducted. Participants completed a questionnaire capturing socio-demographic information and knowledge and practices related to hand hygiene, using face masks, and social distancing . Each correct response received one mark. Overall knowledge scores were categorized as poor (<60%), average (60-80%), or good (>80-100%). Results: Of 192 participants, the majority were female (82.8%) and had >5 years of experience (82%). Findings revealed that 45.8% had poor knowledge of hand hygiene, and the knowledge of 43.8% of respondents was average. Multivariable logistic regression showed that, after adjustment for age and gender, registered nurses had 2.1 times increased odds (95% CI 1.0, 4.2) of having good knowledge compared to other nursing categories. Regarding mask-wearing, 53.6% of nurses had average and 27.1% had good knowledge. Multivariable logistic regression showed that, after adjustment for age and gender, registered nurses had 3.3 times increased odds (95% CI 1.5, 7.4) of having good knowledge compared to nursing assistants. 68.6% of respondents followed the correct steps of handwashing every time, and 98.3% wore a mask in public places. More than half of the nurses (51.2%) kept a safe distance from others to avoid spreading SARS-CoV-2; one-third were in a crowded place(s) in the past three months, and 55.8% usually followed guidelines for social isolation as recommended by WHO. Conclusion: The study identified knowledge deficiencies related to hand hygiene and wearing masks among nurses. It is imperative to provide additional training on infection control measures.

Preprint REVIEW | doi:10.20944/preprints202309.2044.v1

A Review of Photocatalytic Water Splitting for Hydrogen Production Using Tandem Solar Cell

Nur Ain Atiqah Mohd Amin, Hayyiratul Fatimah Mohd Zaid

Subject: Chemical Engineering, Engineering Keywords: photocatalytic water splitting; photoelectrochemical cell; dye solar cell; tandem solar cell; hydrogen

Online: 29 September 2023 (08:05:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2048.v1

Incidence, Risk and Clinical Course of New-Onset Diabetes after COVID-19: Protocol for a Systematic Review and Meta-Analysis of Cohort Studies

Ananya Talanki, Neha Bajaj, Twinkle Trehan, Thirunavukkarasu Sathish

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: COVID-19; SARS-CoV-2; diabetes; new-onset diabetes; long-COVID; postacute sequelae of SARS-CoV-2

Online: 29 September 2023 (07:50:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2076.v1

Using FAME, SPME GC-MS, Compositional, and Sensory Analysis to characterise the Physicochemical Attributes Waterford Blaa

Rachel Kelly, Sabine M. Harrison, Anne Markey, Tracey Hollowood, Amalia G.M. Scannell

Subject: Food Science And Technology, Biology And Life Sciences Keywords: FAME; SPME GC-MS; Compositional Analysis; Waterford Blaa; Sensory Analysis; Fatty Acid Profile; Volatile Profile

Online: 29 September 2023 (07:30:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2054.v1

Thermal Analysis and Computer Simulation of a Hypereutectic Al-Si Alloy Used for an Automotive Industry Part

Juan P. Fuertes, Antonio Rodriguez, Gurutze Perez, Pedro J. Rivero

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: cooling curves; microstructure; hypereutectic Al-Si alloy; thermal analysis; simulation

Online: 29 September 2023 (07:26:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2069.v1

Postbiotics- Functional Food Materials

Sangiliyandi Gurunathan, Praheep Thangaraj, Jin Hoi Kim

Subject: Food Science And Technology, Biology And Life Sciences Keywords: Postbiotics; prebiotics; probiotics; metabolites; lactic acid bacteria; fermentation

Online: 29 September 2023 (07:25:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2077.v1

Illuminating Dersimelagon: A Novel Agent in the Treatment of Erythropoietic Protoporphyria and X-Linked Protoporphyria

Katelyn E Madigan, Sean R Rudnick, Matthew A Agnew, Numra Urooj, Herbert L Bonkovsky

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: Erythropoietic Protoporphyria; X-linked protoporphyria, oral, dersimelagon

Online: 29 September 2023 (05:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2073.v1

Early Castration in Horses Does Not Impact Osteoarticular Metabolism

Marion Rouge, Florence Legendre, Razan Elkhatib, Christelle Delalande, Juliette Cognié, Fabrice Reigner, Philippe Barrière, Stefan Deleuze, Vincent Hanoux, Philippe Galéra, Hélène Bouraïma-Lelong

Subject: Endocrinology And Metabolism, Biology And Life Sciences Keywords: horse; castration; steroid hormones; cartilage; bone; in vivo metabolism

Online: 29 September 2023 (05:25:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2026.v1

A Structured Narrative Prompt for Large Language Models to Create Pertinent Narratives of Simulated Agents’ Life Events: A Sentiment Analysis Comparison

Christopher J. Lynch, Erik Jensen, Virginia Zamponi, Kevin O'Brien, Erika Frydenlund, Ross Gore

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: narrative generation; simulation; large language models; natural language generation; ChatGPT; structured prompt; prompt engineering; prompt design

Online: 29 September 2023 (05:05:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2033.v1

Analysis of the Forces Driving Public Hospitals’ Operating Costs using LMDI Decomposition: The Case of Japan

Kiyotoshi Kou, Yi Dou, Ichiro Arai

Subject: Public, Environmental And Occupational Health, Public Health And Healthcare Keywords: factor decomposition; operating costs; hospital management; COVID-19; Japan

Online: 29 September 2023 (05:03:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2038.v1

Proactive Fault Diagnosis of a Radiator: A Combination of Gaussian Mixture Model and LSTM Autoencoder

Jeong-Geun Lee, Deok-Hwan Kim, Jang Hyun Lee

Subject: Marine Engineering, Engineering Keywords: PHM; radiator; vibration, anomaly detection; machine learning; PCA; deep learning; LSTM autoencoder; GMM

Online: 29 September 2023 (05:01:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2016.v1

Scattering of Attosecond Laser Pulses on a DNA Molecule During Its Nicking and Bending

Dmitry Makarov, Anastasia Kharlamova

Subject: Biophysics, Physical Sciences Keywords: X-ray; DNA; X-ray diffraction; attosecond pulse; USP; Nick(DNA); bending DNA.

Online: 29 September 2023 (04:55:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2020.v1

45 Years of Tetracycline Post Exposure Prophylaxis for STIs and the Risk of Tetracycline Resistance: A Systematic Review and Meta-Analysis

Chris Kenyon, Vanbaelen Thibaut., Sheeba Manoharan-Basil

Subject: Internal Medicine, Medicine And Pharmacology Keywords: doxycycline PEP, tetracycline, minocycline, AMR, PrEP, gonorrhoea

Online: 29 September 2023 (04:50:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2028.v1

Measurement of the Diffusion Coefficient of Xenon in Self-Sintered Nanopore Graphite for Molten Salt Reactor

Pengda Li, Qiantao Lei, Heyao Zhang, Mingbo Qi, Jinliang Song, Pengfei Lian, Jinxing Cheng, Qingbo Wang, Zhongfeng Tang, Zhanjun Liu

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: Diffusion; Graphite; Fission products; Ion implantation; RBS

Online: 29 September 2023 (04:45:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2047.v1

Anatomical Cross Sections and Magnetic Resonance Imaging of the Juvenile Atlantic Puffin Head (Aves, Alcidae, Fratercula arctica)

Marcos Fumero-Hernández, Mario Encinoso, Ayose Melian, Himar Artiles, Doaa Salman, José Raduan Jaber Mohamad

Subject: Anatomy And Physiology, Biology And Life Sciences Keywords: anatomical section; magnetic resonance imaging; head; seabirds; Atlantic puffin

Online: 29 September 2023 (04:44:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2030.v1

Unraveling Fetal Cells in Maternal Circulation - A Review of Current Insights and Uncharted Territories

Cassondra Axen, Victoria Mastej, Richard D. Minshall, Kishore K. Wary

Subject: Cell And Developmental Biology, Biology And Life Sciences Keywords: Angiogenesis; blood vessels; endothelial cells; fetal cells; Flk1; migration; placenta; pregnancy; trophoblast; vasculogenesis; VEGF; VEGFR2

Online: 29 September 2023 (04:40:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2034.v1

Carbetocin Inhibits Ethanol Behavioral Sensitization in Male and Female Mice Independent of Corticosterone Levels

Beatriz Yamada Costa, Luana Gasparini Santos, Priscila Marianno, Mariana Rae, Marina Gomes Almeida, Malcon Brito, Rosangela dos Santos Eichler, Rosana Camarini

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: behavioral sensitization; ethanol; oxytocin; addiction; estrous cycle; ethanol self-administration

Online: 29 September 2023 (04:36:43 CEST)

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Oxytocin (OXT), a pro-social peptide, is increasingly recognized as a potential protective substance against drug addiction. In the context of ethanol, previous researches have shown OXT properties to reduce self-administration, alleviate motor impairment in rodents, and reduce craving in humans. However, its role in behavioral sensitization, a neuroadaptive response resulting from repeated drug exposure linked to increased drug incentive, remains unexplored. OXT is also associated with modulating the Hypothalamic-Pituitary-Adrenal (HPA) axis, with corticosterone well-known as a significant factor in behavioral sensitization development. This study aimed to investigate the effects of Carbetocin (CBT), an analogue of OXT, on the expression of behavioral sensitization to ethanol and concurrent alterations in plasma corticosterone levels in male and female Swiss mice. We also aimed to confirm previous studies on OXT impact on ethanol consumption in male mice, but with a focus on CBT, using the two-bottle choice model and drinking in the dark (DID) methodology. For the sensitization study, mice received either ethanol (1.8 g/kg, ip) or saline treatments daily for 15 consecutive days, followed by treatment with carbetocin (0.64 mg/kg, ip) or a vehicle for 6 days. Subsequently, on day 22, all animals underwent an ethanol challenge to assess the expression of behavioral sensitization. Plasma corticosterone levels were measured on days 21 and 22. CBT effectively prevented the expression of ethanol-induced behavioral sensitization in both male and female subjects, with no alterations detected in corticosterone levels. In the ethanol consumption study, following an initial phase of ethanol acquisition, mice underwent a 6-day treatment with CBT i.p or saline before being reexposed to ethanol. We also found a reduction in ethanol consumption due to CBT treatment. In conclusion, carbetocin emerges as a promising and effective intervention in mitigating ethanol-induced behavioral sensitization and reducing ethanol intake, highlighting its potential significance in alcohol addiction treatment.

Preprint REVIEW | doi:10.20944/preprints202309.2000.v1

Analysis of CD74 Occurrence in Oncogenic Fusion Proteins

Jasmine Vargas, Georgios Pantouris

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Cluster of differentiation 74 (CD74); oncogenic fusion protein; fusion gene; CD74-ROS1; CD74-NTRK1; CD74-NRG1; CD74-NRG2a; CD74-PDGFRB; cancer.

Online: 29 September 2023 (04:35:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2049.v1

Diversity of Trematodes in Myotis Bats (Chiroptera, Vespertilionidae) from the Samarskaya Luka (European Russia)

Nadezhda Yu. Kirillova, Alexander A. Kirillov, Victoria A. Vekhnik

Subject: Parasitology, Biology And Life Sciences Keywords: bats; digenea; Myotis spp.; Middle Volga region; Samarskaya Luka National Park

Online: 29 September 2023 (04:32:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2013.v1

Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in D. melanogaster Brain following Volatilized Cocaine or Methamphetamine Administrations

Ana Filošević Vujnović, Lara Saftić Martinović, Marta Medija, Rozi Andretić Waldowski

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Drosophila melanogaster; cocaine; methamphetamine; neurotransmitter concentration; locomotor sensitization; LC-MS/MS

Online: 29 September 2023 (04:30:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2039.v1

NBSTRN Tools to Advance Newborn Screening Research and Support Newborn Screening Stakeholders

Kee Chan, Zhanzhi Hu, Lynn Bush, Heidi Cope, Ingrid A. Holm, Stephen Kingsmore, Kevin Wilhelm, Curt Scharfe, Amy Brower

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: newborn screening; genome sequencing; ethical; legal; social implications (ELSI); NBSTRN; public health; databases; online tools; Recommended Uniform Screening Panel (RUSP)

Online: 29 September 2023 (04:28:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2058.v1

Effects of Total Flavonoids from Taraxacum mongolicum Hand.-Mazz. on Fermentation Quality, Antioxidant Status and Microbial Community of Caragana korshinskii Kom. Silage

Shuai Huang, Can Wen Ke, Qiang Lu, Fei Long Gao, Dong Xiao Zhou, Yan Cheng Ma

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Caragana korshinskii Kom.; flavonoids; Taraxacum mongolicum Hand.-Mazz.; fermentation quality; antioxidant status; microbial community

Online: 29 September 2023 (04:26:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2056.v1

An Insight on the Sufficiency of Waste Eggshells in Hong Kong for Sustainable Commercial Applications in Cementitious Products

Sohail Maqsood, Lam S. S. Eddie, Hei Yi Ng, Muhammad Afzal

Subject: Waste Management And Disposal, Environmental And Earth Sciences Keywords: Country of Origin; Egg Consumption; Egg Types; Gross National Income; Municipal Solid Waste; Population Growth; Recycling; Waste Eggshells

Online: 29 September 2023 (04:22:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2052.v1

Biogenic Synthesis of Zinc Nanocomposites for Controlling Bacterial Pathogenesis and Photocatalytic Degradation of Toxic Water Wastes

Sajid Ali, Tanveer Asghar, Muhammad Ishtiaq Jan, Tahir Ali

Subject: Medicinal Chemistry, Chemistry And Materials Science Keywords: Bacterial resistance; Metal nanoparticles; Rhododendron arboreum; S. aureus; Cell membrane; Photocatalysis

Online: 29 September 2023 (04:12:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2055.v1

Women-Friendly Bike Infrastructures in Turin: Assessing Requirements for a Gender-Inclusive Bike System and Its Potential

Andrea Rosso, Giulia Melis, Stefano Pensa

Subject: Geography, Planning And Development, Social Sciences Keywords: sustainable cities; sustainable mobility; women-friendly cycling; spatial justice; mobility justice

Online: 29 September 2023 (04:11:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2053.v1

Frequency Shift Monitoring of Optical Filter Based on Optical Labels Over FTN-WDM Transmission Systems

Kaixuan Li, Tao Yang, Xue Wang, Sheping Shi, Liqian Wang, Xue Chen

Subject: Telecommunications, Engineering Keywords: optical labels; pilot tone; frequency shift monitoring; faster-than-Nyquist

Online: 29 September 2023 (04:11:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2019.v1

Synergistic Improvement of Mechanical and Corrosion Properties in TiN PVD-Coated Tool Steels via PAN Pre-treatment

Mahdi Dadfar, Hamid Reza Khandan Pour, Tiberio Sanvito

Subject: Metallurgy And Metallurgical Engineering, Engineering Keywords: nitriding; physical vapour deposition (PVD); mechanical properties testing; corrosion; scratch hardness

Online: 29 September 2023 (04:08:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2032.v1

Fuzzy Normed Algebras Generated by Homomorphisms

Ali Reza Khoddami, F. Kouhsari

Subject: Analysis, Computer Science And Mathematics Keywords: fuzzy normed algebra; homomorphism; separate continuity

Online: 29 September 2023 (04:04:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2031.v1

The Mediterranean Diet for Adolescents With Type 1 Diabetes: A Prospective Intervention

Neriya Levran, Noah Levek, Bruria Sher, Elinor Mauda-Yitzhak, Noah Gruber, Arnon Afek, Efrat Monsonego-Ornan, Orit Pinhas-Hamiel

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: Mediterranean diet; food frequency questionnaire; Israel Mediterranean diet screener (I-MEDAS); time-in-range (TIR); type 1 diabetes; dietary reference intake

Online: 29 September 2023 (04:00:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0940.v2

Switched Auto-regressive Neural Control (S-ANC) for Energy Management of Hybrid Microgrid

Muhammed Cavus, Yusuf Furkan Ugurluoglu, Huseyin Ayan, Adib Allahham, Kabita Adhikari, Damian Giaouris

Subject: Control And Systems Engineering, Engineering Keywords: auto-regressive; control and optimization; energy management; recurrent neural network; long short-term memory; microgrid; switched model predictive control

Online: 29 September 2023 (03:44:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2024.v1

D2MFNet: a Dual-Domain Multi-Frequency Network for Side-Scan Sonar Image Detection

Wen Wang, Yifan Zhang, Houpu Li, Xue Gong, Lei Liu, Yixin Kang

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: target detection; side-scan sonar images; seabed object; frequency domain

Online: 29 September 2023 (03:40:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1992.v1

Genome-Wide Identification of Cotton MicroRNAs Predicted for Targeting Cotton Leaf Curl Kokhran Virus-Lucknow

Muhammad Aleem Ashraf, Judith K Brown, Muhammad Shahzad Iqbal, Naitong Yu

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Cotton leaf curl Kokhran virus; microRNAs; RNA interference; prediction; computational algorithms; target binding sites; host-virus interaction

Online: 28 September 2023 (18:36:58 CEST)

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Cotton leaf curl Kokhran virus (CLCuKoV) (genus, Begomovirus; family, Geminiviridae) is highly infectious, widespread and the most dangerous pathogen of cotton (Gossypium hirsutum L.) that is responsible to a serious disorder, cotton leaf curl disease (CLCuD). Begomoviruses are spread very efficiently by the whitefly Bemisia tabaci cryptic species, causing economic losses to cotton crop, all over the world. The ‘Lucknow’ strain of CLCuKoV has emerged as a divergent isolate that could cause CLCuD. The monopartite ssDNA genome of CLCuKoV-Lu (2.7 Kb) contains six open reading frames (ORFs) that was shown to encode four major proteins. RNA interference (RNAi)-based antiviral innate immunity is a sequence-specific biological phenomenon and a powerful tool to control plant viruses. The present study aims to determine cotton locus-derived microRNAs (ghr-miRNAs) that are identified for targeting the CLCuKoV-Lu ss-DNA-encoded mRNAs using a predictive approach that involves four computational algorithms, miRanda, RNA22, psRNATarget and RNAhybrid. Mature ghr-miRNA sequences (n=80) from allotetraploid upland cotton (2n = 4x = 52) were selected from the miRBase and were tested for alignment with the CLCuKoV-Lu genome. Among the 80 cotton locus-derived ghr-miRNAs evaluated, only one consensus cotton locus-derived ghr-miRNA (ghr-miR2950) was concluded to have effective ghr-miRNA target site at common nucleotide position 82 in the CLCuKoV-Lu genome respectively, using a stringent criterion, identified by all the algorithms used. The miRNA targeting is reliant on base pairing of miRNA-mRNA target pairings. Conservation of the hybridization binding site of the predicted ghr-miR2950 was validated using multiple sequence alignment within all the strains of CLCuKoV. We constructed a regulatory interaction network of miRNA–mRNA to identify novel targets. The efficacy of the predicted miRNAs against CLCuKoV-Lu was evaluated by RNAi-mediated targeted mRNA cleavage. The current investigated miRNA targets provide evidence for the development of CLCuD-resistant cotton plants.

Preprint ARTICLE | doi:10.20944/preprints202309.1976.v1

Integration of Metabolomics and Transcriptomics to Explore Dynamic Alterations in Fruit Color and Quality in ‘Comte De Paris’ Pineapple during Ripening Processes

Kang Hua Song, Jia Meng Liu, Quan Sheng Yao, Yi Xing Li, Xiao Wan Hou, Sheng Hui Liu, Xun Xia Qiu, Yue Yang, Li Chen, Ke Qian Hong, Li Jing Lin, Xiu Mei Zhang

Subject: Biology And Life Sciences, Horticulture Keywords: pineapple; ripening; yellowing; fruit quality; metabolomics; transcriptomics

Online: 28 September 2023 (18:24:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1944.v1

Mechanical Property Degradation of Entangled Metallic Wire Materials under Vibration Environment: Experiments and Prediction Models

Yanhong Ma, Tianyu Liang, Yongfeng Wang, Zhizhou Wang, Jie Hong

Subject: Engineering, Mechanical Engineering Keywords: entangled metallic wire material; vibration experiment; cyclic compressive loads; mechanical property degradation; prediction model

Online: 28 September 2023 (18:21:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1913.v1

Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature

IOANNIS BOUTAS, Adamantia Kontogeorgi, Sophia N Kalantaridou, Constantine Dimitrakakis, Panagiotis Patsios, Maria Kalantzi, Theodoros Xanthos

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: breast cancer; cardiovascular Disease; hypertension; atrial Fibrillation; myocardial Infarction

Online: 28 September 2023 (18:13:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1996.v1

Administration of Gas6 Attenuates Lung Fibrosis via Inhibition of the Epithelial-Mesenchymal Transition and Fibroblast Activation

Ye-Ji Lee, Minsuk Kim, Hee-Sun Kim, Jihee Lee Kang

Subject: Medicine And Pharmacology, Other Keywords: Gas6; Axl; EMT; Fibroblast activation; Pulmonary fibrosis

Online: 28 September 2023 (18:06:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1919.v1

Longitudinal Analysis of Neuraminidase Antibodies to Influenza a Viruses after Immunization with Seasonal Inactivated Influenza Vaccines

Mariia V. Sergeeva, E Romanovskaya-Romanko, V Krivitskaya, Polina Kudar, N Petkova, K Kudrya, D Lioznov, M Stukova, Y Desheva

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: influenza; vaccines; antibodies; neuraminidase-inhibition; persistence.

Online: 28 September 2023 (17:59:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1876.v1

Analysing the Parallels and Trajectories of Social Media and Big Tobacco

Ryan Thomas Williams

Subject: Business, Economics And Management, Business And Management Keywords: public health; social media; misinformation; addiction

Online: 28 September 2023 (17:56:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1941.v1

DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients

Dorota Butkiewicz, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Krzysztof Składowski, Tomasz Rutkowski

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA repair; genetic polymorphism; head and neck cancer; radiotherapy; survival; CHEK1; MRE11; XRCC5; XRCC6; RAD51; LIG4; ATM; TP53; NBS1

Online: 28 September 2023 (17:54:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1907.v1

A Broad-Spectrum Antibody-Based Immunochromatographic Assay for Rapid Screening of BADGE and Its Derivatives in Canned Foods

Chundi Yu, Jinnuo Hu, Wei Wu, Yongfei Zhou, Can Zhang, Qingli Yang

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Bisphenol A diglycidyl ether; derivatives; broad-spectrum polyclonal antibodies; AuNPs; immunochromatographic; canned food

Online: 28 September 2023 (17:24:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2023.v1

A Simplified Evaluation Framework for Adaptation Measures to Urban Heat Islands

Hideki Takebayashi

Subject: Engineering, Architecture, Building And Construction Keywords: adaptation measure; urban heat island; outdoor human thermal environment; mist spray; sunshade; watering road

Online: 28 September 2023 (13:38:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2018.v1

Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment

Darren Avinash Gopaul, Angel Vaillant

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Systemic Lupus Erythematosus; steroids; psychosis; DSM-V

Online: 28 September 2023 (13:37:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2025.v1

Electron Swarm Parameters of Alcohols from Electron Collision Cross–Sections

Marcelo Gomes Da Silva, Maikel Yusat Ballester

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: n/a; Alcohols cross-sections; electron swarm parameters; two-term Boltzmann solver; multi-term Boltzmann equation

Online: 28 September 2023 (13:32:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2022.v1

Drought Characterization in Croatia Using E-OBS Gridded Data

João Filipe Santos, Lidija Tadic, Maria Manuela Portela, Luis Angel Espinosa, Tamara Brleković

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Gridded dataset; Standardized Precipitation Evapotranspiration Index (SPEI); Drought regionalization; Kernel occurrence rate estimator; Trend analysis; Climate indices

Online: 28 September 2023 (13:30:24 CEST)

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Droughts are among the major natural hazards that are spreading to many parts of the world with huge multi-dimensional impacts. For Continental Croatia an extensive analysis of drought phenomenon is presented based on meteorological E-OBS gridded dataset (0.25° x 0.25°), within the period of 1950 to 2022. The drought events were characterized by the Standardized Precipita-tion Evapotranspiration Index (SPEI) applied to different time-scales (6 and 12 months) in order to describe the subannual and annual variability of drought. The spatiotemporal patterns of drought are obtained through principal component analysis (PCA) and K-means clustering (KMC) applied to the SPEI field. An areal drought evolution analysis and the changes in the frequency of occur-rence of the periods under drought conditions were achieved by using a kernel occurrence rate es-timator (KORE). The Modified Mann-Kendall (MMK) test coupled with the Sen’s slope estimator test are applied to the SPEI series in order to quantify the drought trends throughout the country. According to drought events history and considering the different morphoclimatic characteristics of the study area the results showed that Croatia could be divided into three different and spatial-ly well-defined regions with specific temporal and spatial characteristics of droughts (Central North, Eastern and Southern regions). It is shown that there is a manifest increase in the percent-age of area affected by drought as well as in the yearly drought occurrences rates in both Central North and Eastern regions and an evident decrease in the Southern region for both 6 and 12 month SPEI time-scales. In the observation of the drought temporal characteristics, it was found that downward trends expressing increasing drought severities were strongly significant in North and Eastern regions while a few significant upward trends were seen in Southern region. From this study, it is possible to obtain a broader view of the historical behaviour of droughts in Croatia with results providing useful support for drought risk assessment and decision-making processes.

Preprint ARTICLE | doi:10.20944/preprints202309.1917.v1

In Silico Drug Re-Purposing Studies for the Discovery of Novel MbtA Inhibitors

Gourav Rakshit, Abanish Biswas, Venkatesan Jayaprakash

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Mycobacterium; Antibiotic resistance; Drug re-purposing; MbtA; Siderophores; Molecular Docking; Molecular Dynamics; PCA analysis

Online: 28 September 2023 (13:28:39 CEST)

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Tuberculosis (TB) continues to pose a global health challenge, exacerbated by the rise of drug-resistant strains. The development of new TB therapies is an arduous and time-consuming process. To expedite the discovery of effective treatments, computational structure-based drug re-purposing has emerged as a promising strategy. From this perspective, conditionally essential targets present a valuable opportunity, and the mycobactin biosynthesis pathway stands out as a prime example highlighting the intricate response of Mycobacterium tuberculosis (Mtb) to changes in iron availability. This study focuses on the re-purposing and revival of FDA-approved drugs (library) as potential inhibitors of MbtA, a crucial enzyme in mycobactin biosynthesis in Mtb conserved among all species of mycobacteria. Literature suggests this pathway to be associated with drug efflux pumps, which potentially contribute to drug resistance. This makes it a potential target for antitubercular drug discovery. Herein we utilized cheminformatics and structure-based drug repurposing approaches, viz., molecular docking, dynamics, and PCA analysis, to decode the intermolecular interactions and binding affinity of the FDA-reported molecules against MbtA. The virtual screening revealed ten molecules with significant binding affinities and interactions with MbtA. These drugs, originally designed for different therapeutic indications (4: antiviral, 3: anticancer, 1: CYP450 inhibitor, 1: ACE inhibitor, and 1: leukotriene antagonist), are repurposed as potential MbtA inhibitors. Furthermore, our study explores the binding modes and interactions between these drugs and MbtA, shedding light on the structural basis of their inhibitory potential. Principal component analysis highlighted significant motions in MbtA-bound ligands, emphasizing the stability of the top Protein-Ligand Complexes (PLCs). This computational approach provides a swift and cost-effective method for identifying new MbtA inhibitors, which can subsequently undergo validation through experimental assays. This streamlined process is facilitated by the fact that these compounds are already FDA-approved and have established safety and efficacy profiles. This study has the potential to lay the groundwork for addressing the urgent global health challenge at hand, specifically in the context of combating Antimicrobial Resistance (AMR) and Tuberculosis (TB).

Preprint COMMUNICATION | doi:10.20944/preprints202309.1969.v1

A Comprehensive Analysis of the Public Discourse on Twitter about Exoskeletons from 2017 to 2023

Nirmalya Thakur, Kesha A. Patel, Audrey Poon, Rishika Shah, Nazif Azizi, Changhee Han

Subject: Computer Science And Mathematics, Computer Science Keywords: Twitter; Data Analysis; Big Data; Exoskeletons; Data Science; Text Analysis; Sentiment Analysis; Content Analysis; Natural Language Processing

Online: 28 September 2023 (13:25:30 CEST)

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The work of this paper presents multiple novel findings from a comprehensive analysis of about 150,000 tweets about exoskeletons posted between May 2017 and May 2023. First, findings from content analysis and temporal analysis of these tweets reveal the specific months per year when a significantly higher volume of Tweets was posted and the time windows when the highest number of tweets, the lowest number of tweets, tweets with the highest number of hashtags, and tweets with the highest number of user mentions were posted. Second, the paper shows that there are statistically significant correlations between the number of tweets posted per hour and different characteristics of these tweets. Third, the paper presents a multiple linear regression model to predict the number of tweets posted per hour in terms of these characteristics of tweets. The R2 score of this model was observed to be 0.9540. Fourth, the paper reports that the 10 most popular hashtags were #exoskeleton, #robotics, #iot, #technology, #tech #innovation, #ai, #sci, #construction and #news. Fifth, sentiment analysis of these tweets was performed using VADER and the DistilRoBERTa-base library. The results show that the percentage of positive, neutral, and negative tweets were 46.8%, 33.1%, and 20.1%, respectively. The results also show that in the tweets that did not express a neutral sentiment, the sentiment of surprise was the most common sentiment. It was followed by the sentiments of joy, disgust, sadness, fear, and anger. Furthermore, analysis of hashtag-specific sentiments revealed several novel insights, for instance, for almost all the months in 2022, the usage of #ai in tweets about exoskeletons was mainly associated with a positive sentiment. Sixth, text processing-based approaches were used to detect possibly sarcastic tweets and tweets that contained news. Finally, a comparison of positive tweets, negative tweets, neutral tweets, possibly sarcastic tweets, and tweets that contained news, in terms of different characteristic properties of these tweets are presented. The findings reveal multiple novel insights, for instance, the average number of hashtags used in tweets that contained news has considerably increased since January 2022.

Preprint ARTICLE | doi:10.20944/preprints202309.1948.v1

Antimicrobial Activity of Bone Scaffolds Impregnated with Silver Nanoparticles on Bacterial and Fungal Biofilm

Leticia Ramos Dantas, Letícia Kraft, Geiziane Aparecida Gonçalves, Victoria Stadler Tasca Ribeiro, Maria Alice Witt, Everdan Carneiro, Felipe Francisco Tuon

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Biofilm; silver; bone; nanotechnology; impregnation; bacteria

Online: 28 September 2023 (13:23:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2010.v1

Enhanced Antioxidant and Anti-Glycation Abilities of Beeswax Alcohol in Reconstituted High-Density Lipoprotein with Potent Wound-Healing Activity and Protection of Embryo from Acute Toxicity of Carboxymethyllysine in Zebrafish

Kyung-Hyun Cho, Seung-Hee Baek, Hyo-Seon Nam, Ashutosh Bahuguna

Subject: Biology And Life Sciences, Life Sciences Keywords: Beeswax alcohol (BWA); High-density lipoproteins (HDL); Reconstituted HDL; Carboxymethyllysine (CML); Zebrafish; Embryo

Online: 28 September 2023 (13:15:56 CEST)

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The antioxidant and anti-inflammatory abilities of beeswax alcohol (BWA) are well reported in animal and human clinical studies, with a significant decrease in malondialdehyde (MDA) in blood, reduction of liver steatosis, and decrease in insulin. On the other hand, there is insufficient information to explain the in vitro antioxidant activity of BWA because it is extremely insoluble in aqueous buffer system. The BWA mixture was incorporated into reconstituted HDL (rHDL) with apoA-I, and the physiological functions of BWA in a water system were evaluated. After synthesis of rHDL with palmitoyloleoyl phosphatidylcholine (POPC), cholesterol, apolipoprotein A-I (apoA-I), and the BWA at molar ratios of 95:5:1:0 (rHDL-0), 95:5:1:0.5 (rHDL-0.5), and 95:5:1:1 (rHDL-1) for POPC:FC:apoA-I:BWA, the particle size of rHDL-1 was increased 15% compared to rHDL-0. rHDL-1 exhibited the strongest anti-glycation activity, up to 18% less glycation than rHDL-0 treated HDL3, with the highest protection of apoA-I from proteolytic degradation: a 28% larger band intensity than that of rHDL-0 treated HDL3 in the presence of fructose (final 250 mM). The antioxidant ability to inhibit cupric ion-mediated LDL oxidation increased as the BWA content in rHDL increased. The rHDL-1-treated LDL exhibited the smallest oxidation extent in electromobility with the least quantification of oxidized species (MDA). The antioxidant activities of HDL, ferric ion reduction ability (FRA), and paraoxonase (PON) were enhanced by the BWA in rHDL treatment with a concomitant increase in the molar ratio. rHDL-1-treated HDL showed 20–22% higher FRA and PON activities than rHDL-0-treated HDL. A microinjection of each rHDL into zebrafish embryos was performed in the presence of carboxymethyllysine (CML). The rHDL-1 injected embryo exhibited the highest survivability (~63%), whereas the CML alone group showed 28% survivability. A higher BWA content in rHDL helped neutralize the CML toxicity, resulting in higher survivability and normal developmental morphology. In contrast, the CML alone injected embryo showed severe retardation of the developmental speed and morphological defect. The CML-alone group showed the highest extent of reactive oxygen species (ROS) production and cellular apoptosis in embryos, but a co-injection of rHDL-1 resulted in a remarkable decrease in ROS and apoptosis. The dermal application of rHDL containing BWA resulted in higher potent wound-healing activity in a dose-dependent manner with decreased reactive oxygen species and cellular apoptosis in the cutaneous wound area in the presence of CML. Conclusively, incorporating BWA in rHDL significantly enhanced the anti-glycation and antioxidant activities in rHDL via more stabilization of apoA-I with a larger particle size. The rHDL containing BWA facilitated enforced inherent antioxidant ability of HDL and anti-inflammatory activity to suppress the CML toxicities in zebrafish embryos and to ameliorate CML-aggravated chronic wounds in adult zebrafish.

Preprint ARTICLE | doi:10.20944/preprints202309.1958.v1

Morality, Wholesomeness, and Consumption. Cannabis Regulatory Regimes in Ecuador

Andrés Fernando Rodríguez Mera

Subject: Social Sciences, Sociology Keywords: regulatory regimes; control devices; cannabis; rights extension; rights denial

Online: 28 September 2023 (13:12:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2005.v1

A Probabilistic Methodology for Determining Collision Risk of Marine Animals with Tidal Energy Turbines

Andrea Copping, Dan Hasselman, Charles Bangley, Joel Culina, Max Carcas

Subject: Biology And Life Sciences, Aquatic Science Keywords: Risk assessment; tidal stream energy; environmental effects; collision risk; marine renewable energy

Online: 28 September 2023 (13:04:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1922.v1

Production of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from CO₂ by pH-Stat Jar Cultivation of Engineered Hydrogen-Oxidizing Bacterium Cupriavidus necator

Kenji Tanaka, Izumi Orita, Toshiaki Fukui

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: polyhydroxyalkanoate; PHBHHx; CO2; Cupriavidus necator; hydrogen-oxidizing bacterium; high cell density cultivation; jar-cultivation

Online: 28 September 2023 (13:03:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2006.v1

Equine endothelial Cells Show Pro-Angiogenic Behaviours in Response to FGF2 but not VEGF-A

Elizabeth Jane Tessa Finding, Ashton Faulkner, Caroline Wheeler-Jones

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: equine; endothelial; angiogenesis; comparative

Online: 28 September 2023 (13:01:45 CEST)

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