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Preprint CASE REPORT | doi:10.20944/preprints202312.0541.v1

Cytomegalovirus Pneumonia in Down Syndrome

Francesco Perrotta, Donato Piscopiello, Daniela Rizzo, Gaetano Iosa, Giorgio Garzya, Piero Calò, Daniele Gemma

Subject: Clinical Medicine, Medicine And Pharmacology Keywords: Down Syndrome; Pneumonia; Cytomegalovirus

Online: 9 December 2023 (09:18:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0632.v1

Enhancing Breast Cancer Therapy: Nanocarrier-Based Targeted Drug Delivery

Ramendra Pandey, Ruby Dhiman, Nancy Bazad, Riya Mukerjee, Jasmina Vidic, Elcio Leal, V. Samuel Raj, Chung-Ming Chang

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: Breast cancer; Nanocarriers; Tumor location; Diagnostics

Online: 9 December 2023 (08:19:16 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202312.0622.v1

Safeguarding Lives: SUDEP Awareness and Empathetic Discussions in Epilepsy Management

Anisa Isulfi, Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Epilepsy; Awareness; Prevention; SUDEP

Online: 8 December 2023 (17:03:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0643.v1

Effects of Training and Calibration Data on Surface Electro-Myogram-Based Recognition for Upper Limb Amputees

Pan Yao, Kaifeng Wang, Weiwei Xia, Yusen Guo, Tiezhu Liu, Mengdi Han, Guangyang Gou, Chunxiu Liu, Ning Xue

Subject: Engineering, Bioengineering Keywords: surface electromyogram; cross-session gesture recognition; model calibration; amputee; intelligent prostheses

Online: 8 December 2023 (16:10:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0641.v1

Porcine β-defensin 114: Creating a Dichotomous Response to Inflammation

Guoqi Su, Sheng Huang, Shan Jiang, Li Chen, Feiyun Yang, Zuohua Liu, Guixue Wang, Jinxiu Huang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: defensins; lipopolysaccharide; RNA-seq; RAW264.7; inflammation; mice

Online: 8 December 2023 (16:06:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0642.v1

Characteristics of Abnormalities in Somatosensory Submodalities Observed in Residents Exposed to Methylmercury

Shigeru Takaoka, Tadashi Fujino, Shin-ichi Shigeoka, Takashi Yorifuji

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: methylmercury; long term exposure; symptoms; neurological findings; somatosensory submodalities; quantitative sensory examination; nerve conduction study

Online: 8 December 2023 (16:01:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0639.v1

Design and Testing of a New Type of Push-Water Aerator Device for Integrated Pond Aquaculture Systems

Kang He, Chengbiao Tong, Lv hang He, Hao yu Liu, Hao yu Hu

Subject: Engineering, Other Keywords: Pond integrated; aerators; DO; push-water; test; power efficiency

Online: 8 December 2023 (15:46:18 CET)

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Over the last ten years, the integrated pond aquaculture (IPA) has been developing rapidly as a new aquaculture mode, and mechanical power oxygenator is a common oxygenation device in this aquaculture mode. However, with the gradual expansion of the application range of this aquaculture mode, the problems of low efficiency, poor oxygenation uniformity, and low applicability of mechanical power oxygenators, which can produce water reflux and suction pollution accumulation, have gradually emerged. Therefore, we designed a new type of push-water aerator device (NPWAD) applicable to the integrated recirculating water aquaculture mode of ponds. Mainly, the specific parameters of the key components were clarified through the selection calculation and structural design, and the experiments were carried out in the self-constructed pond integrated aquaculture system at the experimental base. The experiments were carried out on the water in the tank for grass carp culture, and the oxygenation and water pushing effects of the type of push-water aerator device under 15 groups of different operating parameters were carried out by using multiple types of high-precision water quality monitoring sensors, with the rotational speed of the device, the operating time (0-30 min) and the height of the water (0.5-1.5 m) as the independent variables, and the oxygenation amount R, the oxygenation power efficiency E_s and the surface layer of the water as the evaluation indexes, average flow velocity V_f were used as its evaluation indexes of oxygenation and water pushing. The results show that the optimal parameters of the NPWAD are impeller water lifting component speed n_1=1000r/min, small-hole aeration component speed n_2=2280r/min. At this time, the average oxygen increase of this device is R=1.96mg/L, the average oxygenation power efficiency is E_s=3.8 kg·(h·kW)-1, the DO uniformity of the water M_1=95.3%, and the average flow velocity V_f=190.8mm/s, which can effectively promote the water directional flow and achieve the water circulation and layer exchange, and it is in line with the preferred swimming speed of grass carp at various growth stages. The new type of push-water aerator device is able to enhance the DO concentration of the water faster, but also to achieve the purpose of promoting the directional flow of the water and renewing the water in the tank, as well as in a short period of time to improve the uniformity of the DO of the water faster, for the improvement of the pond aquaculture production efficiency has practical significance.

Preprint ARTICLE | doi:10.20944/preprints202312.0638.v1

Crosstalk between G-Quadruplexes and Dnmt3a-Mediated Methylation of c-MYC Oncogene Promoter

Alexander Viacheslavovich Sergeev, Andrei Gennadievich Loiko, Adelya Iskandarovna Genatullina, Alexander Sergeevich Petrov, Elena Aleksandrovna Kubareva, Nina Germanovna Dolinnaya, Elizaveta Sergeevna Gromova

Subject: Biology And Life Sciences, Life Sciences Keywords: G-quadruplexes; c-MYC promoter, DNA methylation; Dnmt3a; DNA-protein interaction

Online: 8 December 2023 (15:20:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0631.v1

An Overview of Parenteral Nutrition from Birth to Adolescence, Based on a Composite Fish Oil Containing Lipid Emulsion and a Pediatric Amino Acid Solution

Olivier GOULET

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: intestinal failure, parenteral nutrition, home parenteral nutrition, fish oil based intravenous lipid emulsion, crystalline amino acids solution, multi-chamber bags

Online: 8 December 2023 (15:19:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0637.v1

Estimation of Astronomical Seeing with Neural Networks at the Maidanak Observatory

Artem Yu. Shikhovtsev, Alexander V. Kiselev, Pavel G. Kovadlo, Evgeniy A. Kopylov, Kirill E. Kirichenko, Shuhrat A. Ehgamberdiev, Yusufjon A. Tillayev

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: turbulence; optical turbulence; seeing; telescope; neural network

Online: 8 December 2023 (15:05:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0630.v1

Secondary Sarcopenia and Spinal Cord Injury: Clinical Correlations and Health Outcomes

Anamaria Gherle, Carmen Delia Nistor Cseppento, Diana Carina Iovanovici, Iulia Ruxandra Cevei, Mariana Lidia Cevei, Danche Vasilieva, Stefania Deac, Dorina Stoicanescu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: spinal cord injury; sarcopenia; immobilization osteoporosis; spasticity

Online: 8 December 2023 (14:40:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0633.v1

A Complete Pipeline for Heart Rate Extraction from Infant ECG

Harry T. Mason, Astrid Priscilla Martinez-Cedillo, Quoc C. Vuong, M. Carmen Garcia-de-Soria, Stephen Smith, Elena Geangu, Marina I. Knight

Subject: Computer Science And Mathematics, Signal Processing Keywords: ECG; Infant ECG; Heart Rate; R-Peaks; Open-Source; Naturalistic; Longform

Online: 8 December 2023 (14:39:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0634.v1

Blackening Mechanism of Zn-Mg-Al Alloy Coated Steel Pre-pared by Water Vapor Treatment

Sang-hee Kim, You-jin Kang, Kyung-hwang Lee, Jun Kang, Myeong-hoon Lee, Yong-sup Yun

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: ZnO; ZnO1-x; Oxidation; Oxygen-deficient oxide; Optical bandgap energy

Online: 8 December 2023 (14:37:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0610.v1

Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets

Alvina I. Khamidullina, Yaroslav E. Abramenko, Alexandra V. Bruter, Victor V. Tatarskiy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: replication stress; DNA damage response; ATR; CHK1; PARP; WEE1; PKMYT1; Cyclin dependent kinases

Online: 8 December 2023 (13:59:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0629.v1

The Impact of Household Dynamics on Land Use Change in China: Past Experiences and Future Implications

Yaxue Luo, Ruishan Chen, Bo Xiong, Nan Jia, Xiaona Guo, Chenglong Yin, Wen Song

Subject: Environmental And Earth Sciences, Geography Keywords: population structure; household structure; housing demands; land use change

Online: 8 December 2023 (13:37:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0623.v1

Genome Analysis of Epsilon Crass-like Phages Revealed That Some of Them Can Be Temperate Phages Encoding Atypical Diversity-Generating Retroelements

Igor V. Babkin, Artem Y. Tikunov, Ivan K. Baykov, Vera V. Morozova, Nina V. Tikunova

Subject: Biology And Life Sciences, Virology Keywords: crAss-like phages; genome sequence; diversity-generating retroelements; temperate phages; phylogenetics; virus taxonomy; 3D modeling

Online: 8 December 2023 (13:28:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0616.v1

Comparative Pore-Connectivity and Wettability Characteristics of the Fresh-Water and Saline Lacustrine Tuffaceous Shales: Triggering Mechanisms and Multi-Scale Models for Differential Reservoir-Forming Patterns

Wei Yang

Subject: Engineering, Energy And Fuel Technology Keywords: tuffaceous shale; devitrification; wettability; pore connectivity; Yanchang Formation; Jingjingzigou Formation

Online: 8 December 2023 (13:17:24 CET)

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The continental shale layers are more complex in matrix pore-microfracture interactions and connectivity characteristics under the influence of tuff devitrification, which limits the explicit understanding of the coupling relationship between wettability and pore structure, as well as hydrocarbon flow behavior. Therefore, the influence of tuffaceous components on the reservoir formation mechanism and oil-rich effect of the continental shale formation system is a critical issue to be solved. The Upper Triassic Yanchang Formation tuffaceous shale in Ordos Basin and the Middle Permian Jingjingzigou Formation tuffaceous shale in the southern margin of Junggar Basin is taken as the research objects, using whole-rock mineral composition analysis, FE-SEM observation and digital image processing and extraction, as well as wettability angle determination and spontaneous imbibition experiments to illustrate the influence of the difference of devitrification extent on reservoir pore connectivity and interfacial wettability in two different environments of freshwater and saline lacustrine basins, and summarize the reservoir formation differential pattern under the influence of devitrification. The results show that the saline lacustrine is significantly modified by devitrification. The pore plane porosity of the devitrified tuffaceous shales in the saline lacustrine is higher than that of the tuffaceous shales in the freshwater; the oleophilic of the saline lacustrine tuffaceous shales is better than that of the tuffaceous shales in the freshwater, moreover, the pore connectivity of the saline lacustrine tuffaceous shales is better than that of the tuffaceous shales in the freshwater. Wettability and connectivity control the storage performance of shale oil in the tuffaceous shales formation system. The more oleophilic the reservoir wettability is, the better the pore connectivity is, and the better the reservoir of tuffaceous shale formation system is. According to the different extents of devitrification, two different reservoir formation models of freshwater and saline lacustrine are established, which are of great theoretical and practical significance to enrich the theory of shale oil enrichment and reservoir formation in the continental shale formation system and to guide the exploration of continental shale oil benefits.

Preprint ARTICLE | doi:10.20944/preprints202312.0612.v1

The Role and Impact of Controlling Obstacles with Barriers of Solar Air Collectors for Sustainable Energy Usage with Smart Grids

Abdollah Bashiri, M.A Maysami, Arman Jalali, Derya Betul UNSAL, Ahmet Aksöz, S.M. Muyeen

Subject: Engineering, Electrical And Electronic Engineering Keywords: Smart Grid; Solar Energy; Solar flat plate air collector; Thermal efficiency

Online: 8 December 2023 (13:16:30 CET)

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The use of solar energy holds significant importance within the context of smart grid infrastructure, which is specifically designed to promote environmental preservation and long-term sustainability. Solar collectors are integral components of solar energy systems. Consistent maintenance of solar collectors will enhance energy efficiency and mitigate the use of energy resources. The aforementioned studies hold significance in the context of transitioning to a smart grid, particularly for developing nations. They provide light on how the existing energy production framework may facilitate the transformation of the conventional grid into a smart grid. This study focused specifically on the investigation of solar energy systems utilised as thermal energy sources. The energy efficiency of solar air collectors is diminished because of their low specific heat capacity and least expensive facilities to supply warm air for various applications. In addition, this study emphasizes investigating the enhancement of collector efficiency using double-layer glass coated collectors including arch-shaped obstacles. Three collectors were constructed with distinct features. The first collector, denoted as SC120, was designed without any obstacles and featured a double-layer cover as the witness. The second collector, referred to as SC121, incorporated obstacles with a width of 4 cm along with a double-layer cover. Lastly, the third collector, designated as SC122, included obstacles with a width of 7 cm arranged in a different configuration, also accompanied by a double-layer cover. A blower was installed in each collection to facilitate the forced air flow directed towards the absorbent material, ensuring that the volumetric flow rate remained consistent throughout all collectors. The trials were conducted over a span of five consecutive days, from 9 a.m. to 6 p.m., in an outdoor setting throughout the summer season. The findings indicated that the thermal efficiency of SC122 exhibited a 17% increase compared to SC121, and a 35.7% improvement relative to SC120. The presence of obstacles has a notable impact on thermal efficiency, with rough barriers leading to increased efficiency due to their ability to enhance the rate of heat absorption from the absorbent plate by the blown air.

Preprint ARTICLE | doi:10.20944/preprints202312.0615.v1

Secure Cloud Computing By A dual-Layer Encryption Mechanism

Sanaa Ali Jabber, Soukaena Hashem, Shtha Jafer

Subject: Computer Science And Mathematics, Security Systems Keywords: cloud; storage; secure; SOA; AES; RSA; LSTM

Online: 8 December 2023 (13:15:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0617.v1

An Open-Source Face-Aware Capture System

Md Abdul Baset Sarker, SM Safayet Hossain, Naveenkumar G Venkataswamy, Stephanie Schuckers, Masudul H Imtiaz

Subject: Engineering, Electrical And Electronic Engineering Keywords: Face-aware; Face Quality; Jetson processor; AES encryption; Quality assessment; Passport

Online: 8 December 2023 (13:14:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0621.v1

Identification of Mobile Resistome in Soils Exposed to Different Impacts in Fildes Peninsula, King George Island

Matías Giménez, Gastón Azziz, Silvia Batista

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Resistome; plasmids; Antimicrobial resistance genes; Metagenomics.

Online: 8 December 2023 (13:14:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0620.v1

Pharmacovigilance in Brazil: The Government Monitoring of the Side Effects Caused by Vaccines against COVID-19 – a Narrative Review

Mariana Carvalho, Ivone Duarte, Rui Nunes

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Farmacovigilância; COVID 19; Vigilância em Saúde Pública; Farmacovigilância em vacinas; Efeitos adversos às vacinas; Vacinas no Brasil; . COVID-19 no Brasil

Online: 8 December 2023 (13:12:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0603.v1

In-Silico Molecular Analysis of the Inverse Interaction between Cancer and Alzheimer’s Disease

Bright Kwaku Anyomi, Kwadwo Fosu, Sylvanus Kampo, Tingting Liu, Jianshe Wei

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer's disease; inverse; breast; colorectal cancer; prostate; expression

Online: 8 December 2023 (13:11:58 CET)

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Introduction: Depending on the kind of cancer and neurological disorders, there might be a direct or inverse link between neurodegeneration and cancer. The inverse interaction between cancer and Alzheimer's pathology has garnered substantial interest in medical research. While this inverse interaction between Alzheimer's pathology and cancer presents a fascinating scientific puzzle, there is still limited information and studies on the potential mechanisms involved in this inverse rela-tionship. Aim: This study aims to identify potential genes from Alzheimer's disease that may protect against cancer. Method: The Gene Expression Omnibus (GEO) database provided the Alzheimer's pathology dataset, and GEO 2R was utilized to examine genes that were differentially expressed. The expression of upregulated Alzheimer's pathology genes in breast, colorectal, and prostate cancer was compared using VENN 2.1, colorectal, and prostate cancer was compared using VENN 2.1, and colorectal and prostate cancers were compared using VENN 2.1. Results: Among the upregulated genes associated with Alzheimer's disease, 25 genes are shared among breast cancer, colorectal cancer, and prostate cancer, while 28 of these genes were exclusive to Alzheimer's dis-ease. Gene expression profiling interactive analysis among the shared genes revealed that AQP1, C4A, CSRP2, CRYAB, MACF1, HSPB2, and NEAT1 were downregulated in breast, colorectal, and prostate cancers. These genes have varying roles in cancer progression and suppression. Functional analysis of Alzheimer's disease-related upregulated genes revealed that C1orf56 and HIST1H2AC control cell proliferation, with HIST1H2AC playing a role in necroptosis. Additionally, C1orf56 worked as an oncogenic modifier to support DNMT3B's tumor suppressor properties. Conclusion: Given the role of HIST1H2AC and C1orf56 in the negative control of cell proliferation and their upregulation in Alzheimer's disease, there is a need to further investigate HIST1H2AC and C1orf56 as potential tumor suppressors responsible for Alzheimer's disease and cancer inverse association.

Preprint SHORT NOTE | doi:10.20944/preprints202312.0614.v1

Rapidly Progressive Glomerulonephritis: The Pathology of the Rapid Progression(crescent Formation) and Associated Mechanisms and Aetiologic Factors

Aaisha Mirza, Dev Desai, Hussein Al-azzawi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: RPGN; Pathology; Aetiology

Online: 8 December 2023 (13:10:12 CET)

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Rapidly progressive glomerulonephritis, the term coined for a subtype of nephritic syndrome, is characterized by a state of acute loss of renal function, along with those components of renal damage on urinalysis, over a relatively short period (a few weeks or months). It is the aftermath of an acute, severe glomerular injury. RPGN, famously known as Crescentic glomerulonephritis (cGN) is not a single disease entity but a pattern that can occur in a variety of glomerular diseases caused by different pathologic lesions leading to the development of necrosis in the glomerular capillaries seen in both, systemic and kidney-restricted diseases. While still little is known about the exact etiologic cause behind the primary injury to the capillary wall leading to the development of the condition, many mechanisms are put forth to describe the pathogenesis leading to the progression. Immunopathologic studies have demonstrated that rapidly progressive glomerulonephritis can result from glomerular antibody deposition, can be immune complex-mediated, or from some as yet undefined mechanism that doesn’t involve glomerular antibody deposition. The condition is often severe with poor prognosis as it develops so rapidly and with extensive glomerular involvement, the damage is almost irreversible. Many elements can be associated with the occurrence and progression of the disease but it often involves a disruptive immune response one way or the other. RPGN’s morphological hallmark, the extensive extra-capillary cellular proliferation into the bowman’s space, commonly known as crescent formation which is often observed by electron microscopic view of the tissue biopsy, is considered one of the great diagnostic approaches for the detection of the disease. Also, the severity of the disease is related to the nature and type of immunologic process causing the disease and (in part) to the degree of crescent formation, that can only be observed by histopathological studies. This activity attempts to explain the etiology and pathogenesis involved in the development leading to the rapid progression of the disease.

Preprint ARTICLE | doi:10.20944/preprints202312.0606.v1

Estimation of Genetic Diversity and Number of Unique Multilocus Genotypes (MLGs) of Cassava Germplasm from Burkina Faso Using Simple Sequence Repeat (SSR) Markers

Monique SORO, Serge Marie Felicien Wend-Pagnagdé Zida, Koussao Somé, Fidèle Tiendrébéogo, Daniel H. Otron, Justin S. Pita, James B. Néya, Daouda Koné

Subject: Biology And Life Sciences, Plant Sciences Keywords: cassava, genotypes, genetic diversity, SSRs markers, population structure, Unique multilocus genotypes

Online: 8 December 2023 (13:08:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0628.v1

A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza a Virus

Natalya Eshchenko, Mariia Sergeeva, Evgenii Zhuravlev, Kira Kudria, Elena Goncharova, Andrey Komissarov, Grigory Stepanov

Subject: Biology And Life Sciences, Virology Keywords: IFITM; Influenza A virus; Human cells; WI-38; Genome editing; CRISPR/Cas9; RNA-seq

Online: 8 December 2023 (12:42:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0581.v1

A Perfect Load Forecasting Strategy (PLFS) for Smart Grids Based on Artificial Intelligence

Asmaa Hamdy Rabie, Ahmed I. Saleh, Said H. Abd Elkhalik, Ali E. Takieldeen

Subject: Engineering, Other Keywords: Artificial Intelligence; Load Forecasting; Feature Selection; Outlier Rejection

Online: 8 December 2023 (12:42:36 CET)

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Recently, the application of Artificial Intelligence (AI) in many areas of life has allowed raising the efficiency of systems and converting them into smart ones, especially in the field of energy. Integrating AI with power systems allows electrical grids to be smart enough to predict the future load, which is known as Intelligent Load Forecasting (ILF). Hence, suitable decisions for power system planning and operation procedures can be taken accordingly. Moreover, ILF can play a vital role in electrical demand response, which guarantees a reliable transitioning of power systems. This paper introduces a Perfect Load Forecasting Strategy (PLFS) for predicting future load in smart electrical grids based on AI techniques. The proposed PLFS consists of two sequential phases, which are; Data Preprocessing Phase (DPP) and Load Forecasting Phase (LFP). In the former phase, input electrical load dataset is prepared before the actual forecasting takes place through two essential tasks, namely feature selection and outlier rejection. Feature selec-tion is done using Advanced Leopard Seal Optimization (ALSO) as a new natural inspired opti-mization technique, Citation: To be added by editorial staff during production. Academic Editor: Firstname Last-name Received: date Revised: date Accepted: date Published: date Copyright: © 2023 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). While outlier rejection is accomplished through Interquartile Range (IQR) as a measure of statis-tical dispersion. On the other hand, actual load forecasting takes place in LFP using a new pre-dictor called; Weighted K-Nearest Neighbor (WKNN) algorithm. The proposed PLFS has been tested through excessive experiments. Results have shown that PLFS outperforms recent load forecasting techniques as it introduces the maximum prediction accuracy with the minimum root mean square error.

Preprint COMMUNICATION | doi:10.20944/preprints202312.0417.v3

Sequential Therapy with Ropeginterferon Alfa-2b and Anti-PD1 Antibody for Inhibiting Recurrence of Hepatitis B-related Hepatocellular Carcinoma: From Animal Modeling to Phase I Clinical Results

Albert Qin, Chang-Ru Wu, Ming-Chih Ho, Chan-Yen Tsai, Pei-Jer Chen

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Hepatocellular carcinoma; HBV-related; anti-PD1 antibody; ropeginterferon alfa-2b; animal HBV model; clinical trial

Online: 8 December 2023 (12:37:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0627.v1

Optimizing Wheat Pollen Preservation for Enhanced Viability and In Vitro Germination

Irum Khan, Muhammad Kashif Naeem, Armghan Shahzad, Zijin Zhang, Jing Chen, Muhammad Sajjad

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Pollen viability; in vitro pollen germination; preservation; wheat breeding; heat tolerance

Online: 8 December 2023 (12:36:19 CET)

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Wheat pollen, characterized by its short lifespan, exhibits rapid germination after anthesis. The preservation of wheat pollen is contingent upon environmental factors, including temperature, relative humidity, light, and wind. The objective is to develop a method for preserving wheat pollen effectively, specifically for the purpose of breeding. The short longevity of wheat pollen grains renders it impractical to conduct tests for pollen viability and in vitro germination on a large scale. Herein, the impact of storage temperatures and duration was assessed on pollen viability and in vitro germination to optimize storage conditions for preserving pollen viability. Pollen grains from 50 diverse spring wheat genotypes, each with three replicates, were harvested and stored at temperatures of 22°C, -20°C, and 4°C. Subsequently, pollen viability and in vitro germination rates were determined after storage of 1, 3, and 6 days. The results revealed that storage temperatures, durations, genotypes, and their interactions had a statistically significant impact on both pollen viability and in vitro germination. Notably, when pollen was kept at 22°C, almost all genotypes exhibited a loss of pollen viability and in vitro germination after 1, 3, and 6 days of storage. Likewise, storage at -20°C failed to extend pollen germination. However, at a storage temperature of 4°C, the pollen of 36 wheat genotypes exhibited a range of 6-14% in vitro pollen germination and remained viable even for 6 days. Simple linear regression analysis further revealed a significant negative correlation between pollen viability, in vitro germination, and storage time and temperature. In conclusion, our findings underscore 4°C as the optimal temperature for preserving pollen viability and in vitro pollen germination in spring wheat for up to 6 days. The results of the present study suggests that pollen viability of wheat is genotype de-pendent, storage temperature and storage duration. Thus, the 36 wheat genotypes identified during the present work could be efficiently maintained at 4◦C for short-term storage (6 days) and could be further used for genetics and breeding purposes.

Preprint ARTICLE | doi:10.20944/preprints202312.0626.v1

Risk Factors for the Development of Parastomal Hernia: A Retrospective Cross Section Study

Husam Matalqah, Razan Yaseen, Mahmoud M.Abokhsab, Lina E.Matalkeh, Mohammad Matalkeh, Basil Al Taani, Husni Alswalha, Maher Al-Hajjaj

Subject: Medicine And Pharmacology, Surgery Keywords: parastomal hernia, stoma, PSH

Online: 8 December 2023 (12:36:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0625.v1

Transport and Depositing Characteristics of Exhaling Aerosols from Inside of the Human Respiratory Airway

Yaning Feng, Jintao Wang, Xinguang Cui

Subject: Engineering, Bioengineering Keywords: critical exhaled aerosol diameter; exhaled aerosol fraction; human respiratory airway

Online: 8 December 2023 (12:23:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0619.v1

Optimization of N Fertilizer Type and Ridge/Furrow Ratio to Improve Resource Use Efficiency and Grain Yield of Rain‐Fed Winter Wheat in Loess Plateau, China

Shengcai Qiang, Yan Zhang, Junliang Fan, Fucang Zhang, Wen Lin, Zhiqiang Gao, Min Sun, Xiwang Tang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Ridge-furrow ratio; nitrogen fertilizer type; Winter wheat; Soil hydrothermal; Resource use efficiency; Grain yield

Online: 8 December 2023 (12:09:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0609.v1

Alterations in Gene Expression during Incompatible Interaction between Amendoim Cavalo Common Bean and Colletotrichum lindemuthianum

Maike Lovatto, Pedro Soares Vidigal Filho, Maria Celeste Gonçalves Vidigal, Mariana Vaz Bisneta, Alexandre Catto Calvi, Thiago Alexandre Santana Gilio, Eduardo Ansilieiro Nascimento, Maeli Melotto

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: candidate gene expression; common bean–anthracnose interaction; plant defense genes

Online: 8 December 2023 (12:00:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0613.v1

Urban Intellectual Property Strategy and University Innovation: A Quasi-natural Experiment from National Intellectual Property Model City

Qinqin Chen, Xingneng Xia, Yuji Hui, Sheng Zhang

Subject: Social Sciences, Education Keywords: IP strategy; national IP model city; university innovation；DID model

Online: 8 December 2023 (11:34:57 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0618.v1

Cardiac Manifestations after Ingestion of a Commercial Desiccant: A Case Report

Su Jeong Shin, Yun Jeong Kim

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: calcium chloride; poisoning; hypercalcemia; cardiomyopathy

Online: 8 December 2023 (11:25:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0611.v1

Experimental Study on the Influence of Support and Load Conditions on the Shear Strength of Cfrp Reinforced Concrete Members without Shear Reinforcement

Sarah Bergmann, Martin Classen, Josef Hegger

Subject: Engineering, Civil Engineering Keywords: CFRP; continuous beams; distributed loading; experimental study; flexural shear; load arrangement; shear strength; simply supported beam

Online: 8 December 2023 (10:50:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0608.v1

HyperVein: A Dataset for Human Vein Detection from Hyperspectral Images

Henry Ndu, Akbar Sheikh-Akbari, Jiamei Deng, Iosif Mporas

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: hyperspectral imaging; vein detection; image classification

Online: 8 December 2023 (10:38:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0605.v1

The Latest Trends in Cryopreservation of Fungi

Ivana Eichlerová

Subject: Biology And Life Sciences, Other Keywords: basidiomycetes; non-basidiomycete fungi; cryopreservation; long/short-term storage; liquid nitrogene; cryoprotectant

Online: 8 December 2023 (10:37:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0576.v1

Anterior Cruciate Ligament Revision Surgery: Patellar Tendon Graft with or without Anterolateral Ligament Reconstruction?

Marco Pellegrino, Diletta Bandinelli, Alessandro Ninì Trinchese, Giulia Cenci, Ermanno Trinchese

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Anterolateral ligament; anterolateral ligament reconstruction; lateral extraarticular procedure; anterior cruciate ligament reconstructure; anterior cruciate ligament recurrent ropture

Online: 8 December 2023 (10:33:19 CET)

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INTRODUCTION The Anterior cruciate Ligament Reconstruction (ACLR) is a recurrent successfully surgery, however the literature shows from 3 to 15% of failure. Many recurrent ACL roptures are due to technical surgical mistakes, however, even when the neo-ligament is correctly located and well tensioned, a high rate of partial anterolateral rotatory instability can be clinically detected in those patients. We hypothesized that a recurrent ACL injury would often be associated with antero-lateral ligament lesion and so with an high grade pivoting. The purpose of our retrospective study is to demonstrate if, in the recurrent ACLR surgery, the Anterolateral ligament reconstruction (ALLR) is necessary due to restore a correct rotatory stability of the knee, to improve clinical outcomes and to determine a better return to sport activities. METHODS We included a total of 63 patients undergone to ACLR after a LCA recurrent lesion from January 2018 to January 2020 performed by the same surgeon. The pooled data passed through exclusion criteria and we created two different groups: group A with 11 patients (whom undergone to ACLR with bone-patellar-tendon-bone autograft) and group B with 12 patients (whom undergone to ACLR with bone-patellar-tendon-bone autograft + ALLR). A single operator (different from the surgeon) has clinically evaluated the patients with a 18.75 +/- 8.27 month follow-up. LYSHOLM score, IKDC and ACL-RSI scale clinical questionnaires were used to subjectively evaluation. Pivot-shift test and Rolimeter (Aircast Europa) arthrometric evaluation were used for an objective evaluation. All patients have done a knee XR due to confirm the correct bone tunnels direction. All data were meta-analyzed with the IBM-SPSS software (for MAC, version 22.0) and the results were published as media +/- standard deviation or Standard Error or percentage prevalence, when appropriate. To compare all the clinicals and scores data, we used T-Test for same data, Chi-Square for the percentage data. P-values under 0,05 were considered as significant. RESULTS Our study shows as in the recurrent ACLR surgery, the associated ACLR+ALLR is totally necessary and complementary due to statistically significantly reduction of the remaining anterolateral rotatory instability (p-value under 0.05) CONCLUSION Looking at the recent literature and the preliminary results of this study, the anatomical ALL reconstruction associated with the ACLR, should have been chosen as a better surgery practice in the revision surgery due to reduce anterolateral rotatory instability and the percentage of failure, to increase the odds of graft integrations, the clinical outcomes and the percentage of the return to the same level of sports. The indication of this surgery practice should have been custom-made, because it is mandatory to consider the functional necessary levels for the patient and because the rehabilitation needs time, dedication and commitment to achieve the best clinical and functional results.

Preprint ARTICLE | doi:10.20944/preprints202312.0602.v1

On the Inconsistency of: The Classical Propositional Calculus and Its Metatheory

Lukasz Stepien

Subject: Computer Science And Mathematics, Logic Keywords: classical propositional calculus; zero-order logic; zeroth-order logic; consistency in the traditional sense; consistency in the absolute sense; inconsistency; metalogic; metatheory

Online: 8 December 2023 (10:31:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0607.v1

Survey Results of the Oral Hygiene Habits (Pre and Post Recommendations) among Phenylketonuria Patients in Latvia

Iveta Abola, Nikola Anna Intlere, Anda Brinkmane, Sabine Laktina, Agnese Zarina, Lauma Vasilevska, Ingus Skadins, Georgijs Moisejevs, Linda Gailite, Madara Auzenbaha

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: phenylketonuria; oral health; recommendations of daily oral hygiene procedures

Online: 8 December 2023 (10:28:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0578.v1

Study on Failure Energy per Unit Area of Concrete Specimens Based on Minimum Energy Dissipation Theory

Xinyu Liang, Zengbiao Wu

Subject: Engineering, Civil Engineering Keywords: Concrete material; Minimum energy consumption theory; Damage area; Destructive energy

Online: 8 December 2023 (10:27:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0577.v1

Optimizing Forest Fire Prediction: A Comparative Analysis of Machine Learning Models through Feature Selection and Time-Stage Evaluation

Hamed Khosravi, Mohammad Reza Shafie, Ahmed Shoyeb Raihan, Md Asif Bin Syed, Imtiaz Ahmed

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Forest Fire Prediction; CRISP-DM Methodology; Feature Selection; Decision Tree

Online: 8 December 2023 (10:26:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0595.v1

Safety and Efficacy of TKIs in Very Elderly Patients (≥75 Years) with Chronic Myeloid Leukemia

Alessandro Costa, Elisabetta Abruzzese, Roberto Latagliata, Olga Mulas, Ida Carmosino, Emilia Scalzulli, Maria Laura Bisegna, Claudia Ielo, Maurizio Martelli, Giovanni Caocci, Massimo Breccia

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; tyrosine kinase inhibitor; very elderly; safety; efficacy; outcome; dose optimization

Online: 8 December 2023 (10:26:16 CET)

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Background: While outcomes of chronic phase chronic myeloid leukemia (CP-CML) patients aged over 65 years have been extensively evaluated in real-life experiences, limited data exist for the very elderly population (i.e., aged ≥ 75 years), especially for next-generation tyrosine kinase inhibitors (TKIs). In this retrospective study, we sought to evaluate the safety and efficacy of TKIs in this particular setting of patients. Methods: We conducted a retrospective analysis of a multicenter cohort of 123 newly diagnosed CP-CML very elderly patients. Results: The median age at diagnosis was 80 years (range: 75-96). In the first-line, 86.1% of patients received imatinib, 7.1% dasatinib, 5.6% nilotinib, and 0.81% received bosutinib. A total of 31 patients (25.2%) switched to second-line therapy, nine patients to a third-line and one patient to a fourth line of therapy. Resistance to treatment was the primary reason for switching therapy in both the first (64.5%) and second lines (77.7%). At diagnosis, reduced doses were administered in 36.5% of patients, in 61.2% in the second line, and in all patients in subsequent lines of therapy. In first-line setting, 71.9% of patients achieved an early molecular response (EMR, i.e. 3-month BCR::ABL1 IS <10%); at 6, 12, and 24 months, MR3 was reached by 35.7%, 55.7%, and 75.0% of patients, with 16.6%, 35.7%, and 51.7% achieving DMR at the same timepoints. Treatment-free remission (TFR) was successfully attempted in 11 patients. During the follow-up period, adverse events (AEs) were observed in 78.8% of patients, including 22 cases of cardiovascular AEs. Toxicity grade ≥ 3 was more commonly observed in patients treated with standard doses of TKIs compared to reduced doses (p=0.033). Overall, median follow-up was 46.62 months (range: 1.8-206.2), and 43 patients died due to non CML related causes. Three patients died due to disease progression to advanced (n=1) and blastic (n=2) phases. The 5-year overall survival (OS) for the entire cohort was 71.9% (95% CI: 0.63-0.81), with no significant difference between patients treated with standard doses of TKI compared to those treated with reduced doses (p=0.35). Conclusions: TKIs appear to be safe and effective even in very elderly CML patients, and dose optimization strategies yield satisfactory molecular responses for adequate disease control with an improved safety profile.

Preprint ARTICLE | doi:10.20944/preprints202312.0584.v1

Caregiver Burden in Small Animal Clinics: A Comparative Analysis of Dermatological and Oncological Cases

Pollyana T. R. F. Silva, Fernanda M. Coura, Adriane P. Costa-Val

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: burden of care; cat; dog; human-animal interaction; owner

Online: 8 December 2023 (10:25:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0585.v1

Fungal Endophytes: Discovering What Lies within Some of Canada’s Oldest and Most Resilient Grapevines

Shawkat Ali, Harrison Wright, Joey Tanney, Justin Renaud, Mark W. Sumarah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Botrytis; fungal endophytes; grapevines; Diaporthe; small metabolites

Online: 8 December 2023 (10:23:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0552.v1

Prediction of Risk of Exposure to Ammonia Concentration in Broider Chickens Correlated to the Incidence of Diseases

Leonardo V.S. Barbosa, Nilsa Duarte da Silva Lima, Barros Juliana de S.G., Daniella Jorge De Moura, Fernando Estellés, Adrian Ramón-Moragues, Salvador Sanz Calvet, Aránzazu Villagrá

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: ammonia; machine learning; chicken production

Online: 8 December 2023 (10:22:33 CET)

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The objective of the study was to predict the risk of exposure to ammonia concentration in the production of broiler breeds of slow and fast-growing with low and high production density and correlate with the incidence of health injuries in broiler chickens using a learning machine. Two commercial lines of broiler chicken were used, one with fast-growing (Ross®, slaughter age 42 days) and another with slow-growing (Hubbard®, slaughter age 63 days). All slow-growing birds were housed at a density of 32 kg/m2. Fast-growing birds were housed in two different housing densities: low housing density with a final housing density of 16 kg/m2 and high density with a final housing density of 32 kg/m2. A total of 1250 birds were used in this experiment, 450 of which were fast-growing birds and 800 were slow-growing birds. In each room, 306 birds were randomly distributed in 18 boxes (6 boxes for each treatment and 17 birds per box), each with 3 nipple drinkers and a manual feeder. The dimensions of the high-density boxes were 1 x 1.3 m2 , while the low-density boxes had the same number of animals housed in a larger area, with dimensions of 2 x 1.3 m2 . The remaining 319 birds were housed randomly throughout the room and outside the pens to simulate a commercial production system condition (stock density). All birds were fed with an initial commercial feed from day 1 to day 18 of the experiment, and from day 18 until the end, each breed was fed with different feeds according to their nutritional demands. The following data analysis steps were performed: data selection, pre-processing, transformation, mining, analysis, and, interpretation of results. The classification algorithms, decision tree (J48), SMO (Sequential Minimal Optimization), Naive Bayes, and Multilayer Perceptron were applied to the training and test data sets to build a rule model for predicting ammonia risk levels in broiler chickens. The cross-validation technique was used to parameterize the analysis in all models. From the database of the first phase of analysis, with the classifier to predict the risk condition of ammonia concentration, the Spearman correlation coefficient (ρ, rho), considering the presence of pododermatitis, vision/affected and mucosal injury, which includes assessments of the trachea, bronchi, lungs, eyes, paw injuries, and other injuries. A non-parametric correlation measure was applied to injury incidence data as a function of ammonia risk level (1 and 10 ppm) to correlate injury incidence and ammonia level in the conditions studied. The best predictive model capable of evaluating and obtaining better performance was the Multilayer Perceptron when we considered greater accuracy by the level of risk of exposure to ammonia in the broiler chicken production process, including fast and slow-growing. Birds exposed to higher levels of ammonia concentration have a higher correlation coefficient when the relationship between the variables is strong. The Spearman correlation coefficient shows a stronger association between increased risks of ammonia exposure and the incidence of chicken injuries.

Preprint ARTICLE | doi:10.20944/preprints202312.0555.v1

Mortality Trend of Severe COVID-19 in Under-Vaccinated Population Admitted to ICU in French Amazonia

Severine Matheus, Stéphanie Houcke, Guy Roger Lontsingoula, Nicolas Higel, Abesetou Ba, Fabrice Cook, Cyrille Gourjault, Flaubert Nkontcho, Magalie Demar, Mathieu Nacher, Félix Djossou, Didier Hommel, Dabor RESIERE, Jean Marc Pujo, Hatem Kallel

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; delta variant; gamma variant; mortality; French Guiana ; ;

Online: 8 December 2023 (10:21:21 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202312.0553.v1

4-(diphenylphosphoryl)-1-phenylbutane-1,3-dione

Dmitry Tatarinov, Elisa Bajnazarova, Mohsin Ali, Alexey Dovzhenko, Rustem Zairov, Vladimir Mironov, Asiya Mustafina

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: phosphine oxides; ligands; lanthanides; triketones; keto-enolic tautomerism

Online: 8 December 2023 (10:20:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0572.v1

Effect of Calving Season and Related Climatic Factors on Productive Performance in Dairy Cows

Martin Stojnov, Toncho Penev, Dimo Dimov, Ivaylo Marinov

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: calving season; THI; lactation curve; fat content; protein content

Online: 8 December 2023 (10:17:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0571.v1

Passive Surveillance as a Key Tool to African Swine Fever Eradications in Wild Boar: A Standardized Protocol to Find the Carcasses in Mediterranean Area.

Elisabetta Coradduzza, Federica Loi, Francesca Porcu, Daniela Mandas, Fabio Secci, Marco Efisio Pisanu, Cinzia Pasini, Carlo Zuddas, Marcella Cherchi, Daniele Denurra, Ennio Bandino, Antonio Pintore, Vittorio Guberti, Stefano Cappai

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: African swine fever; passive surveillance; carcasses; eradication; mobile app; freedom from animal disease; wild boar

Online: 8 December 2023 (10:16:19 CET)

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African Swine Fever (ASF) is one of the most important and serious contagious haemorrhagic viral disease of domestic pigs and wild boar, associated to high mortality rates and great sanitary and socioeconomic impact on international trade in animal and swine products. The early detection of the disease is often hampered by an inadequate surveillance. Among the surveillance strategies, passive surveillance of wild boar was considered the most effective for controlling African swine fever virus (ASFV). Otherwise, the design of a sufficiently sensitive ASF surveillance system re-quires a solid understanding of the epidemiology related to the local eco-social context, especially in absence of virus detection. Even if the number of carcasses needed to demonstrate the ASF eradication has been established, the scientific context is poor of details on protocols applied to active search the wild boar carcasses. The aim of the study was to describe the strategy applied for passive surveillance implemented in Sardinia, providing detailed information on the protocol applied in the field in term of number of people, dogs, time and space used to active search car-casses in the Mediterranean area. Using a specific tool developed to record, trace, and share on field data (GAIA Observer App), a total of 33 activities for active search the wild boar carcasses were organized during 2021-2023. Most of these activities were planned to find carcasses previously reported by hunters. A total of 24 carcasses were found, only 2 carcasses were not previously reported. The final protocol applied involved 4 people, with an average speed of 1.5 km/hour. When the carcass was reported, about 2 km of distance should be covered in about 1.5 hours to find the carcasses, and even less time was spent when the dog (not trained) was present. In conclusion, it can be stated that for searching for carcasses it is first mandatory a good collaboration with hunters or other forest visitors to report the carcasses, and involve small groups of expert people to active search the carcasses, possible with the use of hunting dogs with no special training.

Preprint ARTICLE | doi:10.20944/preprints202312.0575.v1

Effects of Silicon Content on Oxidation at 1000°C of Aisi 1045, Aisi 5160 and Aisi 9254 Steels.

Guilherme Maranhão Costa, Lioudmila Aleksandrovna Matlakhova, Sergio Neves Monteiro

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: high-temperature; silicon; oxidation

Online: 8 December 2023 (10:14:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0570.v1

Transforaminal Endoscopic Lumbar Lateral Recess Decompression for Octogenarian Patients

Yong Ahn, Jun Hyeok Jung

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: endoscopic; lateral recess; lumbar stenosis; octogenarians; radiculopathy; transforaminal

Online: 8 December 2023 (10:12:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0583.v1

Drainless Technology for Processing High-Moisture Iron-Containing Sludge and Dust

Ibraev I.K., Ibraeva O.T.

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: sludge; dust; processing; dehydration; agglomeration; recycling

Online: 8 December 2023 (10:11:37 CET)

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Annotation. PURPOSE. Development of a drainless energy-saving technology for the processing of high-moisture iron-containing sludge from metallurgical production. RESEARCH METHOD. The regularities of the combined process of chemical dehydration of high-moisture iron-containing sludge by powdered waste of lime and dolomite, hardening and agglomeration by pressing in a single technological cycle on the developed experimental plant are studied. In the course of laboratory studies, the temperature of the mass, the rate of dehydration, the chemical composition of the mixtures, the appearance of the resulting briquettes, the weight loss during agglomeration, the humidity of the mixtures, and the mechanical strength of the briquettes were carried out. RESULTS. New patterns have been established that have made it possible to develop a non-firing method for producing iron-containing material and self-healing briquettes. The essence of the method, which is one of the main provisions of scientific novelty, is to combine the processes of dehydration, self-hardening of the mixture with the process of shaping by applying external pressure to the hardening mixture in molds to obtain agglomerated material in the form of briquettes in a single technological cycle. The proposed technology does not require drying and firing, and a set of strength properties occurs as the material is cooled in air during the day. A new energy-efficient and drainless method for the production of iron-containing briquettes has been developed, which combines the processes of chemical dehydration and agglomeration in one technological cycle. CONCLUSION. The proposed project and technology will allow organizing production for the processing of high-moisture iron-containing sludge and obtaining a complex iron-containing material as a secondary metal-containing raw material for metallurgical plants for the production of steel and rolled metal. and dolomite dust of dry gas cleaning) as dehydrating and binding materials, as well as screening of coke and coal as a reducing agent. The proposed technology also solves the problems of environmental pollution and land acquisition for storage of production waste.

Preprint CASE REPORT | doi:10.20944/preprints202307.0642.v2

A rare case of complete-immunotherapy-responsive metastatic NSCLC with long lasting PFS: a case report and a literature review

Claudia De Intinis, Paolo Izzo, Massimo Codacci-Pisanelli, Luciano Izzo, Daniela Messineo, Simone Sibio, Monica Champagnol, Silvia Lai, Marcello Molle, Sara Izzo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: NSCLC; metastasis; immunotherapy; complete response; case report; literature review

Online: 8 December 2023 (10:10:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0589.v1

Exploring PTX3 as a Diagnostic and Prognostic Marker in Fetal Inflammatory Response Syndrome in Newborns: A Prospective Study

Bahar Öztelcan Gündüz, Ener Cağrı Dinleyici, Neslihan Ayşe Tekin, Ömer Çolak, Arif Mehmet Akşit

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: PTX3; NEWBORN BABY; FETAL İNFLAMMATORY SYNDROME; SEPSİS; RDS

Online: 8 December 2023 (10:09:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0601.v1

Secure Proxy Re-Encryption Protocol for FANETs Resistant to Chosen Ciphertext Attacks

Hyun-A Park

Subject: Computer Science And Mathematics, Security Systems Keywords: Proxy Re-Encryption; FANET (Flying Ad-Hoc Network); off-road accident

Online: 8 December 2023 (10:07:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0573.v1

The Archimedean Origin of Modern Positional Number Systems

Vincenzo Manca

Subject: Computer Science And Mathematics, Mathematics Keywords: Number Representation Systems; Zeroless positional systems; Arithmetic Algorithms; Ordinals; Recursive enumerability

Online: 8 December 2023 (10:06:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0598.v1

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review

Po-Ku Chen, Kuo-Tung Tang, Der-Yuan Chen

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: NLRP3 inflammasome; comorbidities; pathogenic player; therapeutic potential; rheumatoid arthritis

Online: 8 December 2023 (10:01:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0594.v1

Relapses and Serious Infections In Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab: A Swedish Cohort Study

Olof Carlsson, Dagur Ingi Jonsson, Lou Brundin, Ellen Iacobaeus

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuromyelitis optica disorder; anti-aquaporin-4; anti-myelin oligodendrocyte glycoprotein; rituximab; serious infection

Online: 8 December 2023 (09:59:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0579.v1

Driving Population Health through Accountable Care Organizations, Saudi Arabia

Ghanim. Hamid Al-Khattabi

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Accountable Care Organizations; Public Health; Population Health Management; Transform Healthcare; National Transformation Program; Health Agencies

Online: 8 December 2023 (09:54:43 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0597.v1

Comparative Study of Organic Fertilizers on Growth, Development and Economics of Brinjal (Solanum melongena var. Azad B-3) with Reference to Temperature.

vidyasagar yashvardhan, Rambatuk Singh, Devendra pratap singh, Tribhuwan singh

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: organic fertilizers; vermicompost; poultry manure; mustard cake; bonemeal, neemcake

Online: 8 December 2023 (09:25:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0596.v1

Multi-Objective Optimization by Means of Pairs of Functions

Gianni Bosi, Daris Roberto, Magalì Zuanon

Subject: Computer Science And Mathematics, Mathematics Keywords: Pareto optimal elemen; Bi-multi-objective optimization; Interval order; Ambiguity; Markowitz portfolio selection

Online: 8 December 2023 (09:17:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0560.v1

Greater Energy Independence with Sustainable Steel Production

By Sandra Kiessling, Hamidreza Gohari Darabkhani, Abdel-Hamid Ali Soliman

Subject: Engineering, Energy And Fuel Technology Keywords: Energy Independence; Sustainable Steel; Net-Zero

Online: 8 December 2023 (08:36:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0565.v1

What Health Concerns Could Micro and Nanoplastics Pose for Infants? A Review

Antonio Ragusa, Denise Rinaldo

Subject: Environmental And Earth Sciences, Pollution Keywords: Plastic; microplastics; nanoplastics; newborns; breastfeeding; plastic products manufacturers; human behaviors

Online: 8 December 2023 (08:32:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0564.v1

Bridging Digital Competence and Sustainability: Unveiling the Synergistic Potential of Design and Maker Education

Noble Po-kan Lo

Subject: Social Sciences, Education Keywords: maker education; green digital skills; problem-solving; innovation; creativity; engagement; sustainable education

Online: 8 December 2023 (08:31:01 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202301.0155.v3

Benveniste’s Experiments and the So-Called “Water Memory” Phenomenon: an Example of Serendipity?

Francis BEAUVAIS

Subject: Medicine And Pharmacology, Other Keywords: Water memory; High dilutions; Scientific controversy; Serendipity; Experimenter effect

Online: 8 December 2023 (08:25:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0574.v1

Computational Screening and Experimental Validation of Inhibitor Targeting the Complex Formation of Grb14 and Insulin Receptor

Yosuke Ochi, Takanori Matsui, Keitaro Inoue, Kohei Monobe, Hiroshi Sakamoto, Shunsuke Aoki, Junichi Taira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DOCK program; GOLD program; Grb14; insulin receptor (IR); structure-based drug screening (SBDS)

Online: 8 December 2023 (08:24:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0543.v1

Fekete-Szego and Zalcman Functional Estimates for Subclasses of Alpha-Convex Functions Related to Trigonometric Functions

Krishnan Marimuthu, Uma Jayaraman, TEODOR BULBOACA

Subject: Computer Science And Mathematics, Analysis Keywords: Analytic functions; subordination; Carathé; odory functions; sine function; cosine function; alpha-convex functions; starlike and convex functions; coefficient bounds; Fekete-Szeg˝o functional; Zalcman functional

Online: 8 December 2023 (08:04:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0544.v1

A Convergence Criterion for a Class of Stationary Inclusions in Hilbert Spaces

Mircea Sofonea, Domingo A. Tarzia

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: stationary inclusion; projection operator; convergence criterion; convergence results; penalty method, frictional contact problem; elastic constitutive law

Online: 8 December 2023 (08:02:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0547.v1

Comparison Between Different Seasons of the Year in Research for Rotavirus in a State of Brazil

Graziela Picciola Bordoni, Lucas Candido Gonçalves Barbosa, Fernando Santos Lima, Monica De Oliveira Santos, José Daniel Gonçalves Vieira, Paulo Sergio Scalize, Lilian Carla Carneiro

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Rotavirus; Water contamination; Dry period; Rainy period

Online: 8 December 2023 (08:01:08 CET)

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Abstract: Rotavirus (RV) it’s the agent of one of the main causes of severe viral gastroenteritis in the pediatric population, being responsible for a significant portion of deaths related to diarrhea among children under five years. RV are identified as a potential reference pathogen and it is known that the persistence and infectivity of the viral particles can be related to environmental factors. The aim of the study was to identify and correlate the presence of Rotavirus in collective and individual water sources (deep tubular wells, shallow tubular wells, shallow dug wells, springs, surface water, rainwater stored in cisterns and water trucks that were collected from surface water) of rural communities in the state of Goiás, with the seasons in which the collections were made (rainy and dry season). For this, 86 water samples in the dry period and 160 samples in the rainy period were collected. Concentration of water samples, extraction of viral genetic material, cDNA synthesis and molecular tests (qPCR) were performed. When analyzing the presence of RV in the samples in relation to the period studied, RV was found to be more prevalent in the dry season (54.7%) than in the rainy season (20%), showing a strong statistical association with the dry season (p-value < 0.001). The proportion of positive samples in the dry period, considering the type of source, resulted in higher in Shallow dug wells (p-value <0.001), higher in surface waters (p = 0.001) and higher in spring water (p-value = 0.02). The presence of pathogenic microorganisms in water is a public risk problem, enabling the emergence of outbreaks, endemics and epidemics. In the present research, there was an association among the presence of Rotavirus and the dry period of the year, when compared to the rainy period. Describing or identifying the seasonal behavior of pathogens is important for prevention and attention to water treatment and help in the monitoring of the virus in the water sources.

Preprint ARTICLE | doi:10.20944/preprints202312.0550.v1

Human Serum Enriched After Absorption of Fish Cartilage Hydrolysate Enhances the Healing of Primary Human Dermal Fibroblasts Through the Expression of Proteins with Anti-Inflammatory and Immunomodulatory Properties

Julie Le Faouder, Aurelie Gueho, Regis Lavigne, Fabien Wauquier, Line Boutin-Wittrant, Elodie Bouvret, Emmanuelle Com, Yohann Wittrant, Charles Pineau

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: skin health; nutraceuticals; marine hydrolyzed collagen; marine collagen peptides; chondroitin sulfate; glycosaminoglycans; proteomics; wound healing; primary cells; human dermal fibroblasts; clinical; ex vivo

Online: 8 December 2023 (07:53:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0569.v1

Alpha-Synuclein Aggregation and Spread: Implications for the Pathology and Progression of Neurodegenerative Diseases

Alin Bose Johnson, Niharika Modi, Krithik N. Kamath, Raman Rajeshkumar, Vasanth Raj Palanimuthu

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: neurodegenerative diseases; Lewy bodies; neurodegenerative; A53T mutation

Online: 8 December 2023 (07:47:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0514.v1

Macrophage polarization in infectious diseases: PAMP, viru-lence factors, immune signaling and receptors

Cláudio Daniel Cerdeira, Maísa R.P.L. Brigagão

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Macrophage; polarization; receptor; bacteria; virus; fungi; parasites

Online: 8 December 2023 (07:39:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0563.v1

Topside Ionospheric Structures Determined by Automatically Detected DEMETER Ion Perturbations

Mei Li, Hongzhu Yan, Yongxian Zhang

Subject: Physical Sciences, Space Science Keywords: Ionospheric Structures; Ion Perturbations; Automatic detection method

Online: 8 December 2023 (07:37:49 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0566.v1

Bottlebrush Elastomers with Crystallizable Side Chains: Monolayer-Like Structure of Backbones Segregated in Intercrystalline Regions Title

Evgeniia A. Nikitina, Erfan Dashtimoghadam, Sergei S. Sheiko, Dimitri A. Ivanov

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: bottlebrush elastomers; X-ray scattering; polymer crystallization

Online: 8 December 2023 (07:37:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0568.v1

Microstructure Study on Very-High-Cycle Fatigue of an Addi-tively Manufactured Aluminium Alloy via Advanced Charac-terization Methods

Lu Liu, Shengnan Wang, Gang Li, Yifan Ma

Subject: Engineering, Other Keywords: mechanical behavior; aluminium alloy; additive manufacturing; very-high-cycle fatigue (VHCF); crack initiation; microstructure; focused ion beam (FIB); optical microscopy (OM); scanning electron microscopy (SEM); transmission electron microscopy (TEM)

Online: 8 December 2023 (07:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0567.v1

Discrete-Time Adaptive Control for Uncertain Scalar Multiagent Systems with Coupled Dynamics: A Lyapunov-Based Approach

Islam A. Aly, Kadriye Merve Dogan

Subject: Engineering, Control And Systems Engineering Keywords: multiagent system; discerete-time control; adaptive control; coupled dynamics

Online: 8 December 2023 (07:31:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0562.v1

A Comparative Study of Sports Consumption Psychology and Behavior between Chinese and British University Students

Puyan Chi, Xueying Zhu, Yun Bai, Baoping Wang, Aiping Chi, Tao Xiao

Subject: Social Sciences, Psychology Keywords: Exercise Habits; Sports Consumption; Sports Behavior; College Students; China; Britain

Online: 8 December 2023 (05:59:25 CET)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202312.0561.v1

The VIS-Spectrometric Data of Scots Pine Individual Seed Reveal Forecasting Potential for Container-Grown Germination and Seedling’s Dickson Quality Index

Tatyana P. Novikova, Evgeniy P. Petrishchev, Arthur I. Novikov

Subject: Biology And Life Sciences, Forestry Keywords: Pinus sylvestris L.; Scots pine; seed spectrometric feature; individual seed; container-growm germination; RGB color space; L*a*b* color space; seed size; individual seed mass; Dickson quality index (DQI); forest landscape restoration (FLR)

Online: 8 December 2023 (05:47:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0533.v1

ERK1 Is a Regulatory Kinase Coordinating ERK2 Function in Colon Adenocarcinoma

Alessia Parascandolo, Giulio Benincasa, Francesco Corcione, Mikko O. Laukkanen

Subject: Biology And Life Sciences, Life Sciences Keywords: Colon tumorigenesis; ERK1/2; SOD3; migration, invasion; proliferation

Online: 8 December 2023 (04:56:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0557.v1

Decoupling and Cloaking of Rectangular and Circular Patch Antennas and Interleaved Antenna Arrays with Coated Metasurfaces at C-Band Frequencies

Shefali Pawar, Doojin Lee, Harry Skinner, Seong-Youp Suh, Alexander Yakovlev

Subject: Engineering, Electrical And Electronic Engineering Keywords: cloaking; coated metasurfaces; microstrip patch antennas; mutual interference; reduction of mutual coupling

Online: 8 December 2023 (04:46:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0556.v1

Cross-layer Methods for Ad Hoc Networks Review and Classification

Valeriy Ivanov, Maxim Tereshonok

Subject: Engineering, Telecommunications Keywords: cross-layer methods; ad hoc networks; OSI; optimisation; classification; review

Online: 8 December 2023 (04:43:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0559.v1

Organizational Behavior as a key factor to the success of Sustainable Policies and Actions: A research in the Greek Healthcare Sector

Anastasios Sepetis, Ioannis Parlavantzas, Aspasia Goula, Georgios Pierrakos, Fotios Rizos

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Organizational Behavior; Sustainable development; Climate change; Environment; Greece

Online: 8 December 2023 (04:39:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0558.v1

Experimental Evaluation of a Takagi-Sugeno Fuzzy Controller for an EV3 Ballbot System

Rodolfo Enemegio, Francisco Jurado, Jonathan Villanueva-Tavira

Subject: Engineering, Control And Systems Engineering Keywords: ballbot; linear matrix inequalities; parallel distributed compensation; Takagi-Sugeno fuzzy control; Takagi-Sugeno fuzzy model; telecontrol; telemetry; underactuated systems

Online: 8 December 2023 (04:37:49 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0554.v1

A Study on Automated Problem Troubleshooting in Cloud Environments with Rule Induction and Verification

Arnak Poghosyan, Ashot Harutyunyan, Edgar Davtyan, Karen Petrosyan, Nelson Baloian

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: automated troubleshooting; real-time product activity detection; problem root cause analysis; machine learning; explainable AI; proactive SaaS support

Online: 8 December 2023 (04:34:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0488.v1

Adaptive Responses of Biofortified Common Bean Lines to Acidic Soil and High Temperature in the Amazon Region of Colombia

Juan Carlos Suárez, Amara Tatiana Contreras, Milan O. Urban, Miguel Angel Grajales, Stephen E. Beebe, Idupulapati M. Rao

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: energy use; leaf cooling; phenology; photosynthesis; photosynthate partitioning

Online: 8 December 2023 (03:43:07 CET)

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The development of biofortified and stress tolerant common bean lines contribute to counteract micronutrient malnutrition in the current condition of climate variability. Our objective was to evaluate the adaptive responses of biofortified common bean (Phaseolus vulgaris L.) lines under acidic soils and high temperature stress conditions in the Amazon region of Colombia. Adaptive responses were evaluated based on phenological, physiological and agronomic differences under combined stress conditions. A total of 247 common bean lines from the Mesoamerican gene pool were evaluated under field conditions at Florencia, Caquetá, Colombia. The common bean lines evaluated included 146 from F4 families with high iron (Fe) content and 99 common bean lines from F5 families that were obtained from simple crosses, double crosses and backcrosses among different bean lines. Lines with tolerance to combined stress conditions of acidic soil and high temperature were found with grain yields greater than 1,400 kg ha-1 from the F5 (lines: 859, 805, 865, 657) and F4 (lines: 2853, 2796) families. This improved agronomic response is likely due to the greater partitioning of photosynthates from canopy biomass (CB) toward pod formation (pod partitioning index, PPI) and grain filling (pod harvest index, PHI; harvest index, HI), which translated into higher grain yields (GY). GY was correlated with CB (r = 0.36), PPI (r = 0.6), PHI (r = 0.68), and HI (r = 0.8, P<0.001). The physiological responses that contributed toward superior agronomic performance of biofortified common bean lines include greater allocation of energy to the photosynthetic machinery (ΦII) and its dissipation in the form of heat (ΦNPQ) as the leaf temperature differential (LTD) increased under combined stress conditions. Six biofortified common bean lines (F5 lines: 859, 805, 865, 657; F4 lines: 2853, 2796) were identified with multiple stress resistance traits and these lines can serve as parents for further genetic improvement of common bean for multiple stress tolerance in the Amazon region of Colombia.

Preprint REVIEW | doi:10.20944/preprints202312.0536.v1

DNA Barcoding as a Plant Identification Method

Stavroula Letsiou, Panagiotis Madesis, Efstathios Vasdekis, Cinzia Montemurro, Maria E. Grigoriou, George Skavdis, Vasillios Moussis, Antonios E. Koutelidakis, Andreas G. Tzakos

Subject: Biology And Life Sciences, Life Sciences Keywords: DNA Barcoding; species identification; taxonomy; plants; molecular markers

Online: 8 December 2023 (03:34:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0551.v1

An Improved Ambiguity-free Unfolded Co-prime Linear Array Design for DOA Estimation

Pan Gong, Xiaofei Zhang

Subject: Engineering, Electrical And Electronic Engineering Keywords: direction of arrival estimation; improved array arrangement design; improved unfolded coprime linear array; Cramer-Rao bound; multiple signal classification

Online: 8 December 2023 (03:31:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0538.v1

NaCl Tolerance during Germination and Seedling Stages of Tomato (Solanum lycopersicum L.) Lines Native to Mexico

Ariadna Goreti López-Méndez, Juan Enrique Rodríguez-Pérez, José Oscar Mascorro-Gallardo, Jaime Sahagún-Castellanos, Ricardo Lobato-Ortiz

Subject: Biology And Life Sciences, Horticulture Keywords: salt tolerant genotypes; wild tomato; developmental stages; seed germination

Online: 8 December 2023 (03:12:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0542.v1

Evolution and Structure of a Mesoscale Anticyclonic Eddy in the Northwestern Japan Sea and Its Exchange with Surrounding Waters: In Situ Observations and Lagrangian Analysis

Maxim Budyansky, Svetlana Ladychenko, Vyacheslav Lobanov, Sergey Prants, Aleksandr Alekseevich Udalov

Subject: Environmental And Earth Sciences, Oceanography Keywords: northwestern Japan Sea; mesoscale eddy; evolution and structure; Lagrangian analysis

Online: 8 December 2023 (03:02:17 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0417.v2

Sequential Therapy with Ropeginterferon Alfa-2b and Anti-PD1 Antibody for Inhibiting Recurrence of Hepatitis B-related Hepatocellular Carcinoma: From Animal Modeling to Phase I Clinical Results

Albert Qin, Chang-Ru Wu, Ming-Chih Ho, Chan-Yen Tsai, Pei-Jer Chen

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Hepatocellular carcinoma; HBV-related; anti-PD1 antibody; ropeginterferon alfa-2b; animal HBV model; clinical trial

Online: 8 December 2023 (02:53:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0539.v1

Sulfuric Acid Digestion of Anatase Concentrate

Carolina Nogueira Silva, Liliani Pacheco Tavares Nazareth, Monica Elizetti Freitas, Ana Claudia Queiroz Ladeira

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: anatase; titanium; sulphation; phosphorus

Online: 8 December 2023 (01:20:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0549.v1

Multi-Performance-Degradation System Reliability Analysis with Varying Failure Threshold Based on Copula

WeiZHeng Gan, JiaYin Tang

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Linear Wiener process；Multi-Performance-Degradation；Competitive Failure；Copula Function; Variation of Failure Threshold.

Online: 8 December 2023 (01:18:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0546.v1

Cultivation of Vitamin C-Rich Vegetables for Space Radiation Mitigation

Alireza Mortazavi, Helia Yarbaksh, B.F. Bahaaddini Baigy Zarandi, Reza Yarbakhsh, Fatemeh Ghadimi-Moghaddam, SMJ Mortazavi, Masoud Haghani, Donya Firoozi, Lembit Sihver

Subject: Physical Sciences, Radiation And Radiography Keywords: radiation, C-vitamin; solar particle event; SPE; antioxidants; radiation mitigator

Online: 7 December 2023 (19:55:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0548.v1

Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers

Maria Roxana Biricioiu, Mirela Sarbu, Raluca Ica, Željka Vukelić, Svjetlana Kalanj-Bognar, Alina D. Zamfir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: brain cancers; gangliosides; mass spectrometry; biomarker discovery; screening; structural analysis

Online: 7 December 2023 (19:55:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0502.v1

Investigation on the Performance of Battery Thermal Management Based Direct Refrigerant Cooling: Simulation, Validation of Results and Parametric Studies

Suparat Jamsawang, Saharat Chanthanumataporn, Kittiwoot Sutthivirode, Tongchana Thongtip

Subject: Engineering, Mechanical Engineering Keywords: BTMS; Refrigerant Cooling; Evaporation heat transfer; EVs

Online: 7 December 2023 (17:10:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0499.v1

Mapping Soil Organic Carbon Stock and Uncertainties in an Alpine Valley (Northern Italy) Using Machine Learning Models

Sara Agaba, Chiara Ferre, Marco Musetti, Roberto Comolli

Subject: Environmental And Earth Sciences, Soil Science Keywords: SOC stock; DSM; machine learning models; uncertainty mapping

Online: 7 December 2023 (17:03:15 CET)

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In this study, we conducted a comprehensive analysis of the spatial distribution of soil organic carbon stock (SOC stock) and the associated uncertainties in two soil layers (0–10 cm and 0–30 cm; SOC stock 10 and SOC stock 30 respectively), in Valchiavenna, an alpine valley located in northern Italy . We employed the digital soil mapping (DSM) approach within different machine learning models, including multivariate adaptive regression splines (MARS), random forest (RF), support vector regression (SVR), and elastic net (ENET). Our dataset comprised soil data from 110 profiles, with SOC stock calculations for all sampling points based on bulk density (BD), whether measured or estimated, considering the presence of rock fragments. As environmental covariates for our research we utilized environmental variables, in particular geomorphometric parameters derived from a digital elevation model (with a 20 m pixel resolution), land cover data, and climat-ic maps. To evaluate the effectiveness of our models, we evaluated their capacity to predict SOC stock 10 and SOC stock 30 using the coefficient of determination (R2). The results for the SOC stock 10 were as follows: MARS 0.39, ENET 0.41, RF 0.69, and SVR 0.50. For the SOC stock 30, the corresponding R2 values were: MARS 0.45, ENET 0.48, RF 0.65, and SVR 0.62. Additionally, we calculated the Root Mean Square Error (RMSE) and Mean Absolute Error (MAE) for further assessment. To map the spatial distribution of SOC stock and address uncertainties in both soil layers, we chose the RF model, due to its better performance, as indicated by the highest R2 and the lowest RMSE and MAE. The resulting SOC stock maps using the RF model demonstrated an accuracy of RMSE = 1.35 kg.m-2 for the SOC stock 10 and RMSE= 3.36 kg.m-2 for the SOC stock 30. To further evaluate and illustrate the precision of our soil maps, we conducted an uncertainty assessment and mapping by analyzing the standard deviation (SD) from 50 iterations of the best-performing RF model. This analysis effectively highlighted the high accuracy achieved in our soil maps. The maps of uncertainty demonstrated that the RF model better predicts the SOC stock 10 compared to the SOC stock 30.

Preprint ARTICLE | doi:10.20944/preprints202312.0495.v1

Microbiological Collections in Brazil: Current Status and Perspectives

Chirlei Glienke, Desirrê Alexia Lourenço Petters-Vandresen, Aline da Silva Soares Souto, Manuela da Silva, Luciane Marinoni

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: culture collections; biological collections; biodiversity; conservation

Online: 7 December 2023 (16:59:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0497.v1

Cellular Biophysical Markers for Rapid Evaluation of Immune Checkpoint Inhibitors in Radioimmunotherapy Against Glioblastomas

Bayode Ibironke, Kylie Machida, Arij Khan, Jayce Hughes, Melanie Schwengler, Allison Benoit, Erika Jank, Anne Hubbard, Yohan Walter, Andrew Ekpenyong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pembrolizumab; immunotherapy; temozolomide; durvalumab; brain tumor; cell migration; metastasis; glioblastoma; PD-1; PD-L1

Online: 7 December 2023 (16:57:26 CET)

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