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Preprint ARTICLE | doi:10.20944/preprints202310.0077.v1

Evaluation of the Water Consumption and the Productive Pa-Rameters on a Table Grapevine Cultivar Grafted onto Two Root-Stocks, in the Climate Change Context

Antonio Dattola, Vincenzo Vonella, Olivadese Tommaso, Francesco Pullia, Rocco Zappia, Gregorio Antonio Maria Gullo

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: drought, phenology, quality, sap flow, viticulture

Online: 2 October 2023 (16:49:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0081.v1

Biodegradable Cashew Gum Hydrogel in Mombasa Grass Pas-Ture: A Sustainable Option for Agriculture

Dhiéssica Morgana Alves Barros, Ricardo Loiola Edvan, João Paulo Matos Pessoa, Romilda Rodrigues do Nascimento, Luan Felipe Reis Camboim, Leilson Rocha Bezerra, Marcos Jácome de Araújo, Heldeney Rodrigues Sousa, Edson C. Silva-Filho

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: chemical composition; Megathyrsus maximus; morphogenesis; organic hydrogel; planting gel; polymers; synthetic hydrogel.

Online: 2 October 2023 (16:48:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0075.v1

Response of Grassland Vegetation Growth to Drought in Inner Mongolia of China from 2002 to 2020

Anzhou Zhao, Ruihao Xu, Lidong Zou, Xiufang Zhu

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: Vegetation indexes; GOSIF; GPP; Drought events; Inner Mongolia grassland

Online: 2 October 2023 (15:07:22 CEST)

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Drought poses a significant environmental risk and can deeply affect the growth of grasslands. However, there is still uncertainty regarding the precise impact of varying levels of drought on grassland growth. To address this gap, we utilized several key indicators, including the Nor-malized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI), the Global Or-biting Carbon Observatory-2 based Solar-induced Chlorophyll Fluorescence (GOSIF), and the Gross Primary Productivity (GPP), in conjunction with drought indices (the Standardized Precip-itation Evapotranspiration Index (SPEI) and the soil moisture (SM). Our study aimed to compre-hensively assess the consistency of spatio-temporal patterns in grassland vegetation and its re-sponsiveness to different drought levels in the Inner Mongolia region from 2002 to 2020. Results indicated that NDVI, EVI, GOSIF, and GPP in grassland vegetation across Inner Mongolia exhibited significant increasing trends from 2002 to 2020. Specifically, NDVI, EVI, GOSIF, and GPP all dis-played consistent spatial patterns, with 25.83%, 21.18%, 22.65% and 48.13% of the grassland area showing significant increases, respectively. Drought events, as described by SPEI and SM, in June 2007 to September 2007 and June 2017 to July 2017, were selected to evaluated the response of grassland vegetation to drought. The drought events of 2007 and 2017 resulted in reductions in NDVI, EVI, GOSIF, and GPP relative to multi-year average (2002-2020). GOSIF exhibited a more intense response to drought, suggesting that GOSIF may reflect the inhibition of water stress on grassland photosynthesis better than NDVI and EVI during drought in 2007 and 2017. The reduc-tions in NDVI, EVI, GOSIF and GPP in grassland increased significantly across different drought-levels, with the sharpest reductions observed during extreme drought. Under the severe and extreme drought events, the most substantial reductions in NDVI, EVI, GOSIF, and GPP were observed in the temperate steppe (TS). Moreover, the effects of different drought severity levels within the same grassland type varied, with the most significant reductions in NDVI, EVI, GOSIF and GPP observed during extreme drought. Our results provide new perspectives for developing and implementing effective strategies to address grassland carbon cycling management and climate change in Inner Mongolia.

Preprint REVIEW | doi:10.20944/preprints202310.0068.v1

Keap It in the Family: How to Fish Out New Paradigms in Keap1-Mediated Cell Signaling

Marcus J. C. Long, Kuan-Ting Huang, Yimon Aye

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Keap1; electrophile; RES; Nrf2; Wdr1

Online: 2 October 2023 (12:05:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0064.v1

A Comprehensive Analysis of Organic Food: Evaluating Nutritional Value and Impact on Human Health

Azizur Rahman, Parnian Baharlouei, Eleanor Hui Yan Koh, Gabby Pirvu, Rameesha Rehmani, Mateo Arcos, Simron Puri

Subject: Food Science And Technology, Biology And Life Sciences Keywords: organic foods; food safety; obesity; cancer; biodiversity; climate change; organic farming

Online: 2 October 2023 (12:02:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0057.v1

Bibliometric Analysis of Climate Change Impacts on Photovoltaic Energy Production

Nícolas MFTS Araújo, Raphael Abrahão

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: Scientific mapping; greenhouse effect; renewable energy; energy generation; forecasting; review

Online: 2 October 2023 (11:59:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0045.v1

Assessment of Symptom Perception by Visual Analog Scale in Children with Newly-Diagnosed Allergic Rhinitis: The Link with Asthma

Maria Angela Tosca, Irene Schiavetti, Vincenzo Meleca, Matteo Naso, Chiara Trincianti, And Giorgio Ciprandi

Subject: Immunology And Allergy, Medicine And Pharmacology Keywords: Allergic rhinitis; asthma; symptoms; perception; visual analog scale

Online: 2 October 2023 (11:57:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0046.v1

Genetic Characterization of HIV-1 tat Gene from Virologically Controlled HIV-infected Older Patients on Long-term Antiretroviral Therapy

Nathan Kummet, Neha Mishra, Adela Diaz, Nicholas Cusick, Stephen A. Klotz, Nafees Ahmad

Subject: Virology, Biology And Life Sciences Keywords: HIV+ older patients; ART; tat sequences; genetic diversity; CTL epitopes

Online: 2 October 2023 (11:55:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0002.v1

Sound of Sirens, Echoes of Trauma: Unpacking Socioeconomic Vulnerabilities in the Israel-Hamas Conflict

Yaakov Bayer

Subject: Sociology, Social Sciences Keywords: PTSD, Armed conflicts, Socioeconomic status

Online: 2 October 2023 (11:26:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2173.v1

Efficacy of Postprandial Exercise in Mitigating Glycemic Responses in Individuals with Overweight, Obesity, and Type 2 Diabetes – A Systematic Review and Meta-Analysis

Jie Kang, Brian M Fardman, Nicholas A Ratamess, Avery D Faigenbaum, Jill A Bush

Subject: Endocrinology And Metabolism, Biology And Life Sciences Keywords: Glycemic control, Hyperglycemia, Exercise protocols, Exercise timing, Metabolic disorders

Online: 2 October 2023 (11:25:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2176.v1

Significant social networks of women victims of childhood sexual abuse

Karla Cristina Kurquievicz Buccieri, Adriano Valério Dos Santos Azevêdo

Subject: Psychology, Social Sciences Keywords: Child sexual abuse; Social Networking; Social Support.

Online: 2 October 2023 (11:24:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2171.v1

Pre-exposure prophylaxis for COVID-19 with Tix-agevimab/Cilgavimab in kidney transplant recipients in the Kraken variant (XBB.1.5) era: A Single-center Experience

Biagio Pinchera, Rosa Carrano, Fabrizio Salemi, Amerigo Piccione, Elisa Schettino, Paolo Romano, Emilia Trucillo, Alessia D'Agostino, Marina Sarno, Emanuela Zappulo, Ivan Gentile

Subject: Epidemiology And Infectious Diseases, Medicine And Pharmacology Keywords: Tixagevimab/Cilgavimab, kidney transplantation, SARS-CoV-2, COVID-19, Kraken variant, XBB.1.5, pre-exposure prophylaxis, immunosuppressed patients

Online: 2 October 2023 (11:22:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2172.v1

Compact diode pumped solid state laser with intracavity pump-enhanced DFG emitting at ~3.5 microns

Liam Gerrit Keith Flannigan, Ali Atwi, Tyler Kashak, Daniel Poitras, Chang-qing Xu

Subject: Optics And Photonics, Physical Sciences Keywords: nonlinear optics; difference frequency generation; mid-infrared laser; DPSS laser; linear cavity

Online: 2 October 2023 (11:20:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2178.v1

Expression, characterisation, homology modelling and molecu-lar docking of a novel M17 family leucyl-aminopeptidase from Bacillus cereus CZ

Jie Liu, Tangbing Cui

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: leucyl-aminopeptidase; Bacillus cereus; expression; homology modeling; molecular docking

Online: 2 October 2023 (11:18:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2170.v1

The lag effect of riverine flow discharge and sediment load response to antecedent rainfall with different cumulative durations in red hilly area in China

Lixiang Zhao, Xiaofei Nie, Haijin Zheng, Kaitao Liao

Subject: Water Science And Technology, Environmental And Earth Sciences Keywords: antecedent rainfall; lag time; rainfall event; extreme rainfall; garden land expansion; red hilly area in China

Online: 2 October 2023 (11:16:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2174.v1

Sleep breathing dynamics in children with unilateral cleft lip and palate: A prospective comparative study

Naoko Nemoto, Hitoshi Kawanabe, Kazunori Fukui, Akihiko Oyama, Toru Okamoto, Kazuhiro Shimamura

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: Cleft palate; Apnea Hypopnea Index; out-of-center sleep testing (OCST); respiratory event index (REI)

Online: 2 October 2023 (11:14:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0050.v1

Unleashing the Power of Beneficial Microorganisms for Advancing Crop Improvement: An In-depth Review

Godswill Ntsomboh Ntsefong, Gabriel Mahbou Somo Toukam, Kingsley Tabi Mbi, Seyum Essubalew Getachew, Aoudou Yaouba, Shariati Mohammad Ali, Tonjock Rosemary Kinge, Gerald Ngo Teke

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: Beneficial microorganisms, Crop improvement, Plant-microbe interactions, Biofertilizers, Symbiotic relationships

Online: 2 October 2023 (11:12:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0052.v1

Molecular Mimicry between SARS-CoV-2 proteins and human self-antigens related with autoimmune central nervous system (CNS) disorders.

Elisa Gouvea Gutman, Renan Amphilophio Fernandes, Jéssica Vasques Raposo-Vedovi, Andreza Lemos Salvio, Larissa Araujo Duarte, Caio Faria Tardim, Vinicus Gabriel Coutinho Costa, Valeria Coelho Santa Rita Pereira, Marcos Martins Da Silva, Fabrícia Lima Fontes-Dantas³, Soniza Vieira Alves-Leon

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: COVID-19; SARS-CoV-2; Molecular mimicry; immune tolerance; autoimmune disorders; central nervous system.

Online: 2 October 2023 (11:10:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0055.v1

Potentially pathogenic SORL1 mutations observed in autosomal-dominant cases of Alzheimer’s disease do not modulate bAPP physiopathological processing

Charlotte Bauer, Eric Duplan, Peter St George-Hyslop, Frédéric Checler

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: SORL1, mutations, secretases, bAPP, Ab peptides, C-terminal fragments, neprilysin, proteasome, degradation, cellular localization, transient and stable expressions.

Online: 2 October 2023 (11:08:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0059.v1

Sex-specific Impact of 17β-estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction

Niya Emilova Semerdzhieva, Adelina Dimitrova Tsakova, Julieta Hristova, Valentin Stoychev Lozanov, Vesela Valentinova Loznova, Mariana Gospodinova, Simeon Dimitrov, Petar Yordanov Atanasov, Maria Chaneva

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: 17β-estradiol; total testosterone; oxidized low-density lipoproteins; high-sensitive C-reactive protein; Acute Myocardial Infarction

Online: 2 October 2023 (11:06:33 CEST)

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Estrogens play a protective role during early life stages. However, endogenous 17β-estradiol (E2) can accelerate atherosclerosis progression in low-grade inflammatory conditions like established atherosclerosis. Our single-center cohort study assessed sex-specific associations of gonadal hormones with oxidative stress, inflammation, and myocardial injury markers in 111 patients (37% women) diagnosed with acute myocardial infarction (MI) between July 2011 and December 2013. Blood samples were collected within 48 hours of symptom onset, and we measured sex steroids (E2, total testosterone [T]), oxidized low-density lipoproteins, high-sensitive C-reactive protein (CRP), white blood cell counts (WBC), and cardiac enzymes (creatine kinase [CK], the CK Muscle-Brain fraction [CK-MB], and high-sensitive troponin T [hsTnT]). The SYNTAX score gauged coronary disease severity from coronary angiography results. In men with acute MI, peak cardiac enzyme levels were predicted by post-percutaneous coronary intervention (PCI) E2 plasma levels (OR 1.011, p=0.047 - CK; OR 1.018, p=0.013 - CK- MB; OR 1.019, p=0.005 - TnT), peak WBC count (OR 1.487, p=0.015 - CK ; OR 1,709, p=0,005 - CK- MB; OR 1.391, p=0.012 - TnT), and peak CRP plasma levels (OR 1.040, p=0.033 - CK; OR 1.024, p=0.029 - CK-MB; OR 1.063, p=0.006 - TnT). T levels and E2/T ratio were associated with post-PCI CRP in these men (OR 0.980, p = 0.024 - T, OR 1.010, p = 0.076 - CRP). For women, peak WBC was a marker of highest testosterone (OR 1.348, p = 0.062), and only WBC was a significant indicator of myocardial injury extent (OR 1.426, p=0.039 - CK; OR 1.384, p=0.036 - CK-MB; OR 1.299, p=0.048 - TnT). During acute MI, elevated endogenous estradiol levels correlate with myocardial necrosis severity in men, while in women, increased leukocyte levels indicate acute myocardial damage. Elevated plasma T is associated with increased WBC in women. In men, post-PCI plasma CRP specifically indicates endogenous T levels and E2/T ratio during the acute phase.

Preprint REVIEW | doi:10.20944/preprints202310.0070.v1

Polyomavirus wakes up and chooses neurovirulence

Arrienne B Butic, Samantha A Spencer, Shareef K Shaheen, Aron E Lukacher

Subject: Virology, Biology And Life Sciences Keywords: JCPyV; MuPyV; polyomavirus; progressive multifocal leukoencephalopathy (PML); CNS; antiviral immunity; neurotropic virus

Online: 2 October 2023 (11:04:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0051.v1

Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo

Ester Lopes De Melo, Bruno Augusto Machado Tavares, Abrahão Victor Tavares de Lima Teixeira dos Santos, Adriana Maciel Ferreira, Helison de Oliveira Carvalho, Andres Navarrete Castro, Arlindo César Matias Pereira, Luiz Fernando Moreira, Jose Carlos Tavares Carvalho

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: angiogenesis; nutraceuticals; chorioallantoic membrane; anthocyanins; tocotrienols.

Online: 2 October 2023 (11:01:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0054.v1

At the cross-road of cGAS-cGAMP-STING pathway and DNA damage response: implications for cancer progression and treatment

Tatyana V. Korneenko, Nikolay B. Pestov, Ivan A Nevzorov, Alexandra A. Daks, Olga N. Solopova, Kirill N. Trachuk, Nickolai A. Barlev

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: STING; cGAS; cGAMP; interferon signaling; cancer; metastasis; BRCA; proton channel

Online: 2 October 2023 (10:57:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0071.v1

Recent Advances in the Development of Bioartificial Pancreas Using 3D Bioprinting for the Treatment of Type 1 Diabetes: A Review

Anushikha Ghosh, Arka Sanyal, Abhik Mallick

Subject: Endocrinology And Metabolism, Biology And Life Sciences Keywords: Biomaterials; 3D bioprinting; pancreas; islets; type 1 diabetes; biofabrication

Online: 2 October 2023 (10:43:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0069.v1

Hyaluronic Acid-Conjugated 17β-Estradiol Provide More Effectively to Alleviate Estropause-Induced Cognitive Deficits in Rats

Mu-Hsuan Chen, Hsiao-Chun Lin, Tzu Chao, Viola Szu-Yuan Lee, Chia-Lung Hou, Tsyr-Jiuan Wang, Jeng-Rung Chen

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Cognitive deficit; Alzheimer’s disease; Cholinergic septo-hippocampal innervation system; Dendritic spine; Hippocampus; Morris water maze

Online: 2 October 2023 (10:32:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0067.v1

Modelling Soil Health Indicators to Assess the Effectiveness of Sustainable Soil Management in a Mediterranean Arable Land

Chiara Piccini, Roberta Farina, Claudia Di Bene, Silvia Vanino, Rosario Napoli

Subject: Soil Science, Environmental And Earth Sciences Keywords: long-term sustainability; soil health indicators; fertilization strategies; EPIC model; Central Italy

Online: 2 October 2023 (10:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0063.v1

Diagnostic Assessment in Wet and Dry Seasons of Simple Weirs Constructed by Small-scale Farmers in the Northern Region Provinces of Zambia

Alex Lushikanda KABWE, Masahiro HYODO, Hidehiro OGATA, Yoshihiro SAGAWA, Yoshinao ADACHI, Masayuki ISHII

Subject: Other, Engineering Keywords: ingle-line weir; small-scale irrigation; river diversion; rural areas; up-stream wa-ter level; emerging farmers

Online: 2 October 2023 (09:52:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0062.v1

Evaluation of the Sustainable Forest Management Performance in Forestry Enterprises Based on a Hybrid Multi-Criteria Decision-Making Model: A Case Study in China

Deqiang Deng, Chenchen Ye, Kemeng Tong, Jiayang Zhang

Subject: Business And Management, Business, Economics And Management Keywords: Forestry Enterprise; Sustainable Forest Management; Triple Bottom Line; MCDM Methodology

Online: 2 October 2023 (09:47:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0061.v1

Handheld Ultra-Fast duplex PCR assays and Lateral flow detection and identification of Leishmania parasites for cutaneous leishmanisis diagnosis

Insaf Bel Hadj Ali, Yusr Saadi Ben Aoun, Zeineb Hammami, Oumayma Rhouma, Ahmed Sahbi Chakroun, Ikram Guizani

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: Cutaneous leishmaniases; Molecular diagnosis; Point of care; Leishmania; Molecular target; Palm PCR; Duplex PCR; Lateral Flow immunoassay

Online: 2 October 2023 (09:43:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0060.v1

Using Ecological Momentary Assessments to Understand How Daily Fluctuations in Psychological States Impact Stress, Well-Being, and Health

Summer Mengelkoch, Daniel P. Moriarity, Anne Marie Novak, Michael P. Snyder, George M. Slavich, Shahar Lev-Ari

Subject: Other, Public Health And Healthcare Keywords: Ecological Momentary Assessment; Stress; Well-being; Health; Mood; Social safety; Energy; Present-focus; Burnout; EMA

Online: 2 October 2023 (09:26:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0056.v1

Semiconductor Manufacturing Process Improvement Using Data-Driven Methodologies

Hribhu Chowdhury

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: semiconductor manufacturing; statistical process control (SPC); data mining techniques; data-driven decision models; process improvement; product yield rate; process stability

Online: 2 October 2023 (09:13:34 CEST)

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The paper investigates into the intricacies of semiconductor manufacturing, a highly complex process entailing a wide array of subprocesses and diverse equipment. Semiconductors are miniaturized integrated circuits comprising numerous components. The semiconductor manufacturing process begins with the thin disc-shaped silicon wafers. On each wafer, up to thousands of identical chips can be prepared depending upon the diameter of the wafer to build up the circuits layer by layer in a wafer fab. The size of the semiconductors requires a high number of units to be produced, thus necessitating a large amount of data to control for improving the semiconductor manufacturing process. Therefore, the collection and analysis of the equipment data, process data, and machine history data throughout the manufacturing process are required to diagnose faults, monitor the process, and manage the manufacturing process effectively. This research is focused on improving the semiconductor manufacturing process through a rigorous analysis of collected manufacturing process data, employing statistical process control (SPC), data mining techniques, and data-driven decision models. The project's primary objective is to increase the manufacturing process stability and productivity by utilizing the latest data-driven technologies in the scientific community. A structured review was undertaken, exploring contemporary data-driven methodologies in semiconductor manufacturing process improvement, specifically pertaining to process capability, product yield rate, and process stability. This review accentuates a comprehensive evaluation of data-driven methodologies applicable to conventional semiconductor manufacturing facilities, aiming to drive substantial process improvements. It features a detailed demonstration facilitating the selection of optimal semiconductor manufacturing processes to enhance overall operational performance. This study of process improvement in the semiconductor manufacturing steps through the application of data-driven methodologies will be effective in delivering advanced, real-time, and proactive control decisions throughout the manufacturing facilities. This endeavor is expected to promptly provide critical insights for enterprise manufacturing decision-makers to reduce manufacturing cycle time, improve the product yield rate, and increase the overall efficiency of the manufacturing process.

Preprint ARTICLE | doi:10.20944/preprints202310.0041.v1

Intra-Atlas Node Size Effects on Graph Metrics in fMRI Data: Implications for Alzheimer's Disease and Cognitive Impairment

Sahithi Kolla, Haleh Falakshahi, Anees Abrol, Zening Fu, Vince D. Calhoun

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: functional network connectivity; fMRI; graph metrics; node size; brain networks

Online: 2 October 2023 (08:39:56 CEST)

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Network neuroscience delves into comprehending the intricate arrangement and interactions within the neural networks of the brain. By merging insights from both neuroscience and network theory, it investigates the brain's structure and function through the lens of interconnected nodes (symbolizing brain regions) and edges (symbolizing the connections among these regions) forming a dynamic network. Graph metrics play a pivotal role in neuroscience by providing quantifiable insights into the intricate connectivity patterns within the brain's neural networks. Frequently, nodes are extracted from functional or structural atlases, which can lead to diverse shapes and sizes. Nevertheless, our understanding of how these differing node characteristics and definitions impact the computed graph metrics in neuroimaging data remains limited. This study adopts a data-driven methodology to delineate functional nodes, subsequently examining the influence of their sizes on resultant graph metrics. By employing the Neuromark framework, an entirely automated independent component analysis (ICA) is applied to resting state fMRI data. Through this, functional network connectivity (FNC) matrices are computed—capturing Pearson correlations between component-time courses—while employing a proportional threshold to streamline node connections based on these correlations. Subsequently, various global and local graph metrics are computed, offering insights into network characteristics. Global metrics provide an overarching summary of the network structure, while local measures delve into structural intricacies at the individual component level. Node sizes are computed based on voxel counts surpassing a designated threshold. Next, we calculated the Pearson correlation between the obtained node sizes and the graph metrics, which we term 'node-metric coupling' (NMC). Our findings revealed consistent and noteworthy correlations between the values of graph metrics and the dimensions of brain nodes. To delve deeper into the implications of this correlation, we examined the node-metric coupling within a dataset comprising Alzheimer's disease, mild cognitive impairment, and control subjects. The disparities observed in node-metric coupling among these groups underscore the necessity of accounting for this factor during analysis. The two principal outcomes of this study are as follows: Firstly, the substantial interplay between varying node sizes within a given atlas and the resultant graph metrics; and secondly, the potential utility of node-metric coupling as a viable biomarker for brain disorders. These discoveries hold significant ramifications. While comparing studies employing diverse atlases is already a challenge, our work highlights an additional, critical source of variability: accounting for node sizes. Consequently, the association between intra-atlas node size and graph metric should be thoughtfully acknowledged in future neuroimaging investigations.

Preprint ARTICLE | doi:10.20944/preprints202310.0036.v1

Beyond Words: The Neuroscientific and Multifaceted World of Non-Verbal Communication in Modern Society

Davide Saggese

Subject: Cognitive Science, Social Sciences Keywords: Non-verbal communication; neuroscience; body language; gestures

Online: 2 October 2023 (08:37:59 CEST)

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This publication delves into the intricate world of human communication, extending beyond the realm of spoken and written language to explore the profound influence of non-verbal communication. Focusing on body language—comprising gestures, facial expressions, postures, and movements—it reveals the pivotal role it plays in conveying emotions, intentions, and psychological states. The rapidly evolving fields of neuroscience and cognitive science are investigating the neural mechanisms and cognitive processes that underpin the interpretation and utilization of these non-verbal cues. Notably, the amygdala's involvement in processing emotional facial expressions has provided a neurological foundation for our emotional understanding in non-verbal communication. Concurrently, cognitive psychology sheds light on how perception, attention, and memory influence our interpretation of non-verbal cues and communication strategies.In our modern, technologically advancing society characterized by global interconnectivity and cultural diversity, the significance of non-verbal communication, especially in digital and virtual contexts, is paramount. The transformation of non-verbal expression into digital symbols like emoticons and emojis raises questions regarding its ability to maintain authenticity and emotional understanding. This publication endeavors to comprehensively explore the fundamental role of body language and non-verbal communication in contemporary society. By integrating insights from psychology, neuroscience, social sciences, and digital technologies, it aims to elucidate the underlying mechanisms guiding non-verbal communication. Additionally, it delves into the implications of non-verbal communication across diverse domains, including interpersonal communication, the workplace, politics, advertising, and the virtual world.The research presented herein strives to offer a thorough understanding of interpersonal dynamics, relationships, and social behavior, with the goal of promoting the development of more effective, conscious, and ethically guided communication strategies. Ultimately, this analysis aspires to inspire further interdisciplinary research and reflection, addressing emerging challenges and fully leveraging the potential of non-verbal communication in modern society. This, in turn, guides our path towards a communication landscape that is more inclusive, authentic, and empathetic.

Preprint ARTICLE | doi:10.20944/preprints202310.0053.v1

On the Origin of Aging by Means of Natural Selection

Richard Francis Walker

Subject: Aging, Biology And Life Sciences Keywords: aging vs survival; DNA damage; double-stranded breaks; Gompertz-Makeham Law; developmental regulatory redundancy; tradeoffs vs emergent properties; fecundity; reproductive fitness; redundancy reliabiiity; programmed aging

Online: 2 October 2023 (08:08:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0049.v1

Human-Robot Collaboration in Manufacturing Assembly Tasks

Hribhu Chowdhury

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: Human-Robot Collaboration (HRC); manufacturing assembly; task allocation, reinforcement learning; Cyber-Physical Systems (CPS); Industry 4.0; robotic assembly sequence planning; collaborative robotics

Online: 2 October 2023 (07:38:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0014.v1

The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus

Alessia Valentini, Carmine Cardillo, David Della-Morte, Manfredi Tesauro

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: Non-Communicable Diseases (NCDs); Perivascular Adipose Tissue (PVAT); Endothelial Dysfunction (ED); Cardiovascular Diseases (CVDs); Insulin Resistance (IR); Type 2 Diabetes Mellitus (T2DM)

Online: 2 October 2023 (07:33:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0048.v1

Advances in SMA-Based Reinforcement in Steel Structures: A Review

Chenxi Shao, Yonghui Huang

Subject: Architecture, Building And Construction, Engineering Keywords: steel structure; shape memory alloy (SMA); reinforcement; review

Online: 2 October 2023 (07:29:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0047.v1

Three Dimensional Hydroelasticity of Multi-connected Modular Offshore Floating Solar Photovoltaic Farm

Zhi Yung Tay

Subject: Civil Engineering, Engineering Keywords: hydroelastic response; offshore floating solar photovoltaic farm; very large floating structure; modular floating structure

Online: 2 October 2023 (06:35:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0044.v1

Studies on Structures of Turbulent Swirling Coal Flames by Large-Eddy Simulation

Lixing Zhou, Liyuan Hu

Subject: Energy And Fuel Technology, Engineering Keywords: swirling coal combustion; flame structure; large-eddy simulation

Online: 2 October 2023 (05:11:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0042.v1

A Molecular Dynamics Simulation Study of In- and Cross-Plane Thermal Conductivity of Bilayer Graphene

Rafat Mohammadi, Mohammad Reza Ghaderi, Ebrahim Hajian

Subject: Mechanical Engineering, Engineering Keywords: bilayer graphene; in-plane and cross-plane thermal conductivities; non-equilibrium molecular dynamics; anisotropic thermal transport

Online: 2 October 2023 (05:09:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0039.v1

Study of Photosynthesis-Light Response Curves in Olea europaea L. subsp europaea Cultivars and Their Adaptation to Climate Change

Genoveva Carmen Martos-de la Fuente, Benjamín Viñegla, Elena Illana-Rico, Ana Maria Fernández-Ocaña

Subject: Environmental Science, Environmental And Earth Sciences Keywords: Olea europaea; drought stress; photosynthesis-light response, olive cultivars, cultivar characterisation

Online: 2 October 2023 (04:36:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0037.v1

Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic Syndrome

Luigi Nibali, Abish S Stephen, Robert Allaker, Antonino Di Pino, Valentina Terranova, Marcella Pisano, Salvatore Di Marca, Viviana Ferrara, Roberto Scicali, Francesco Purrello, Nikolaos Donos, Matteo Regolo, Lorenzo Malatino

Subject: Life Sciences, Biology And Life Sciences Keywords: metabolic syndrome; periodontitis; periodontal medicine; cardiovascular disease

Online: 2 October 2023 (04:33:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0040.v1

Progress and Prospect of Quantitative Research on Divination in Yijing

Xinqi Zheng, Haiyan Liu

Subject: Computational Mathematics, Computer Science And Mathematics Keywords: Yijing; overall quantization; five-element quantization; mixed quantization

Online: 2 October 2023 (04:33:15 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202310.0038.v1

Knowledge-Based Prioritization of Genomic Variations: A Quest for Detailed Understanding the Genetic Architecture of Diseases

Ivan Y. Iourov

Subject: Life Sciences, Biology And Life Sciences Keywords: candidate processes; disease; genomic variations; knowledge; medical genomics; ontology; pathways; prioritization; systems analysis; variome

Online: 2 October 2023 (04:26:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0034.v1

Effect of P-dipping on above- and below-Ground Growth of NERICA 4 Rice in Different Soil Types

Emmanuel Odama, Yasuhiro Tsujimoto, Shin Yabuta, Isao Akagi, Rael Chepkoech, Ibrahim Soe, Jun-Ichi Sakagami

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: phosphorus; Oryza sativa L.; nutrient uptake; photosynthetic rate; root morphology

Online: 2 October 2023 (04:18:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0035.v1

The Financial Sustainability of the Romanian SMEs Operating in the Health Sector

Dragos Paun, Florin Duma, Cristian Chifu

Subject: Business And Management, Business, Economics And Management Keywords: healthcare; sustainability; financial performance

Online: 2 October 2023 (04:17:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0033.v1

The Future of Festivity: Christmas, Technology, and the Post-Pandemic Realm

Edgar R. Eslit

Subject: Ethnic And Cultural Studies, Social Sciences Keywords: Christmas; future of festivity; Post-pandemic realm; qualitative study

Online: 2 October 2023 (04:15:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0032.v1

Multifunctional Nanoparticles with Superparamagnetic Mn(II) Ferrite and Luminescent Gold Nanoclusters for Multimodal Imaging

Barbara Casteleiro, Mariana Rocha, Ana R. Sousa, André M. Pereira, José M.G. Martinho, Clara R. Pereira, José P. S. Farinha

Subject: Nanotechnology, Chemistry And Materials Science Keywords: Gold nanoclusters; manganese ferrite nanoparticles; mesoporous silica; multimodal imaging; NIR-photoluminescence; superparamagnetism.

Online: 2 October 2023 (04:07:20 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0027.v1

BIM Role for Circular Economy in the Built Environment Context: A Review and Way Forward

Muhammad Bilal, Muhammad Ali Musarat, Muhammad Afzal, Muhammad Irfan

Subject: Architecture, Building And Construction, Engineering Keywords: circular economy; building information modeling; built environment; building sector; digitalization

Online: 2 October 2023 (04:05:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0399.v36

There Is a Master Reality beyond Each Observer’s Reality

Markolf H. Niemz

Subject: Theoretical Physics, Physical Sciences Keywords: spacetime; cosmology; Hubble constant; Hubble diagram; quantum mechanics

Online: 2 October 2023 (04:04:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0030.v1

Greening Development: Reducing Urban Tree Canopy Loss through Incentives

Elise Willis, Andrew Koeser, Mysha Clarke, Gail Hansen, Deborah Hilbert, Mary Lusk, Lara Roman, Laura Warner

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: By-laws; Construction; Ordinance; Regulations; Tradeoffs; Tree preservation

Online: 2 October 2023 (04:00:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0029.v1

Vitamin D status in Bipolar Disorder

Zita Späth, Adelina Tmava-Berisha, Frederike T. Fellendorf, Tatjana Stross, Alexander Maget, Martina Platzer, Susanne A. Bengesser, Alfred Häussl, Ina Zwigl, Armin Birner, Robert Queissner, Katharina Stix, Linda Wels, Melanie Lenger, Nina Dalkner, Sieglinde Zelzer, Markus Herrmann, Eva Z. Reininghaus

Subject: Psychiatry And Mental Health, Medicine And Pharmacology Keywords: bipolar disorder; vitamin D metabolism; functional vitamin D deficiency; 25(OH)D; 24,25(OH)2D; VMR

Online: 2 October 2023 (03:58:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0031.v1

Global Cardiac Surgery. Accessibility of Cardiac Surgery in Developing Countries: Objectives, Challenges and Solution

Salvatore Agati, Ermanno Bellanti

Subject: Surgery, Medicine And Pharmacology Keywords: global cardiac surgery; global surgery; surgical accessibility

Online: 2 October 2023 (03:56:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0028.v1

Empowering India's Scheduled Castes: Challenges, Reservations, and Pathways to Progress"

Mayank Gupta

Subject: Other, Social Sciences Keywords: Scheduled Castes; Caste system; reservation; social injustice; untouchability

Online: 2 October 2023 (03:55:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0026.v1

Involvement of Heparanase in the Pathogenesis of Acute Pancreatitis: Implication of Novel Therapeutic Approaches

Dalit B Hamo-Giladi, Ahmad Fokra, Edmond Sabo, AVIVA KABALA, Irina Minkov, Salim Hadad, Zaid Abassi, Iyad Khamaysi

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: Acute pancreatitis; Heparanase; Lipase; Amylase; Mitochondria; NSAIDs

Online: 2 October 2023 (03:22:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0025.v1

Ellagic Acid Supplementation Ameliorates Cisplatin-Induced Liver Injury in Mice via the Activation of Nrf2/HO-1 Pathway and the Inhibition of NF-kB Pathway

Xueyong Zhang, Mingchao Liu, Baofu Xie, Yue Li, Zhihui Hao, Zhanhui Wang, Shusheng Tang, Yang Wang, Jianzhong Shen, Chongshan Dai

Subject: Pharmacology And Toxicology, Medicine And Pharmacology Keywords: Ellagic acid; cisplatin; hepatotoxicity; Nrf2/HO-1 pathway; NF-κB pathway

Online: 2 October 2023 (03:19:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0024.v1

Advances in Therapeutic Contact Lenses for Different Ocular Condition Management

Mariana Ioniță, George Mihai Vlăsceanu, Georgian A. Toader, Marius Manole

Subject: Engineering, Bioengineering Keywords: contact lens; drug delivery; bioavailability; composite; gas-permeable; hydrogel

Online: 1 October 2023 (11:18:39 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202310.0004.v1

A Simple Cyst of the Testis was Found Incidentally during Castration for Prostatic Cancer

Mitsuhiro Tachibana, Hideki Hamayasu, Hiromichi Nakagawa, Hayato Nozawa, Shigeki Fukuzawa

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: simple cyst of the testis; mesothelium; ectopic rete testis; prostatic cancer; castration; case report

Online: 1 October 2023 (10:16:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2181.v1

Blockchain-enabled Pharmaceutical Supply Chain under Uncertain Demand: Cost Prediction through the Tuning of Evolutionary Supervised Learning

Hossein Havaeji, Thien-My Dao, Tony Wong

Subject: Engineering, Other Keywords: Blockchain Technology-enabled Pharmaceutical Supply Chain; Uncertain Demand; Supervised Learning algorithms; Evolutionary Computation algorithms; Blockchain Technology

Online: 1 October 2023 (10:14:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2131.v1

Wild Ungulates Constitute the Basis of the Diet of the Iberian Wolf in a Recently Recolonized Area: Wild Boar and Roe Deer as Key Species for Its Conservation

Isabel Barja, Álvaro Navarro-Castilla, Lorena Ortiz-Jiménez, Angel España, Roberto Hinojosa, David Sánchez-Sotomayor, Angel Iglesias, Jose España, Sergio Rubio-Sánchez, Santiago Martín-Romero, Juan Vielva, Fernando Horcajada-Sánchez

Subject: Environmental And Earth Sciences, Ecology Keywords: Canis lupus signatus; domestic ungulates; wild ungulates; Iberian wolf; recolonization

Online: 1 October 2023 (10:12:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0021.v1

Determinants of Perceived Well-Being in Friendship Relationships during Emerging Adulthood: Testing a Structural Model Based on Self-Determination Theory

Farhad Tanhaye Reshvanloo, Hossein Kareshki, Seyed Amir Amin Yazdi

Subject: Social Sciences, Psychology Keywords: perceived well-being in friendship relationships; basic psychological needs; self-regulation; self-determination theory (SDT)

Online: 1 October 2023 (09:50:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0016.v1

Uncovering the Impact of Working from Home on Employees’ Collaboration, Happiness, and Promotion Chances Using Machine Learning

Mehdi Imani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine learning; COVID-19; Working from home; Employees’ collaboration; Employees’ happiness; Employees’ promotion chances

Online: 1 October 2023 (09:48:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0011.v1

Improving Understanding of Consumer Attitudes toward Cultured Meat through the Lens of Online Media Framing

Béré Benjamin Kouarfaté, Fabien Durif

Subject: Business, Economics And Management, Marketing Keywords: Text mining; Cultured meat; Artificial meat; media framing; attitude; social acceptability; Consumer acceptance; consumer behavior

Online: 1 October 2023 (09:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0022.v1

Grafting Starch with Acrylic Acid and Fenton’s Initiator: The Selectivity Challenge

Inge-Willem Noordergraaf, Judy Retti Witono, Hero Jan Heeres

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Starch graft copolymerization with acrylic acid; Selectivity of the grafting reaction; Analysis of different grafting systems in a graphical representation; Water solubility of the monomer as a key factor; The impact of selective starch activation; Assessment of methods to improve selectivity; dedicated dosage of monomer

Online: 1 October 2023 (09:43:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0917.v2

Impact of Varying User Characteristics on The Accuracy of Fall Prediction Algorithms Using Custom Wrist-Worn End Device

Purab Nandi, K R Anupama, Himanish Agarwal, Siddharth Paliwal, Kishan Patel, Vedant Bang, Manan Bharat, Madhen Vyas Guru

Subject: Engineering, Electrical And Electronic Engineering Keywords: Machine learning; Geriartic fall detection; Dataset; Dew Computing; End Device; Feature Extraction; Supervised Machine Learning; Sensor Data Analysis

Online: 1 October 2023 (09:38:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0015.v1

Rooting Meta-ecosystems with Reciprocal Lateral Carbon and Nitrogen Flows in a Yangtze Coastal Marsh

Yu Gao, Bin Zhao, Neil Saintilan, Wanben Wu, Maina Mbui, Li Wen, Feng Zhao, Tao Zhang, Zhi Geng, Gang Yang, Chao Song, Ping Zhuang

Subject: Environmental And Earth Sciences, Ecology Keywords: coastal wetland; carbon; nitrogen; coupling; stoichiometry; meta-ecosystem

Online: 1 October 2023 (08:52:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0017.v1

Relationship Between El Niño-Southern Oscillation and Atmospheric Aerosols in the Legal Amazon

Augusto G. C. Pereira, Rafael Palácios, Paula C. R. Santos, Raimundo Vitor S. Pereira, Glauber Cirino, Breno Imbiriba

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Aerosol; ENSO; Black Carbon; Remote Sensing; Amazon

Online: 1 October 2023 (08:49:12 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202310.0023.v1

When Mast Cells Run Amok: A Comprehensive Review and Case Study on Severe Neonatal Diffuse Cutaneous Mastocytosis

Gheorghe Emilian Olteanu, Mihaela Bataneant, Maria Puiu, Adela Chirita-Emandi

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Neonatal diffuse cutaneous mastocytosis; KIT gene; case report; systemic mastocytosis; review

Online: 1 October 2023 (08:44:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0019.v1

The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding their Preventive Role against Metabolic Syndrome

Mehdi Alami, Kaowtar Boumezough, Khalil Abdelouahed, M'hamed Ramchoun, Samira Boulbaroud, Tamàs Fülöp, Hicham Berrougui

Subject: Biology And Life Sciences, Life Sciences Keywords: Punica granatum L.; pharmacokinetic; metabolic disorders; dyslipidaemia

Online: 1 October 2023 (08:42:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0018.v1

An Exploratory Analysis of the Association Between Hospital Quality Measures and Financial Performance

Brad M Beauvais, Diane Dolezel, Zo Ramamonjiarivelo, Cristian Lieneck, Michael Nowicki

Subject: Public Health And Healthcare, Health Policy And Services Keywords: hospital; quality; patient safety; perceptions of care; financial performance

Online: 1 October 2023 (08:35:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0013.v1

The Reversal Effect of P-Glycoprotein-Mediated Tumor Multidrug Resistance by Pyxinol and 24S-Pyxinol Amino Acid Ester Derivatives

Luying Tan, Peng Gao, Zhuoqiao Li, Chencheng Gao, Xiaoyu Geng, Qianyun Wang, Daohao Tang, Fang Wang, Jinping Liu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: tumor multidrug resistance; P-glycoprotein; pyxinol amino acid ester derivatives; molecular docking; metabolomics

Online: 1 October 2023 (08:32:50 CEST)

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(1) Background: The typical transporter protein, P-glycoprotein (P-gp), has been proven to be associated with multidrug resistance (MDR). Pyxinol and 24S-Pyxinol amino acid ester derivatives had been demonstrated to be promising P-gp inhibitors for reversal of tumor MDR in KBV cells, however, their roles in MDR reversal in other tumor-resistant cells are still unclear. (2) Methods: In the present study, we synthesized 40 amino acid ester derivatives of Pyxinol and 24S-Pyxinol. The MDR reversal effects of these derivatives were evaluated in A549/Tax, MCF-7/ADR, and HCT-8/VCR cells using the CCK-8 assay. Subsequently, western blot assay, intracellular Rhodamine123 (Rh123) accumulation assay and P-gp ATPase activity assay were utilized to investigate the effects of active compound on P-gp. Molecular docking was used to predict the possible binding patterns of active compound to P-gp. Moreover, based on UPLC-Q/TOF-MS cellular metabolomics technology to identify endogenous differential metabolites and metabolic pathways associated with tumor MDR effects of the active compound. (3) Results: The results of the CCK-8 assay showed that compounds 8, 14, 16, 17, 18, 23, 25, 34, 36, 37 exhibited strong MDR reversal effect in A549/Tax, MCF-7/ADR and HCT-8/VCR cells, which were screened by reversal fold (RF) greater than 5. Among them, 10 μM of derivative 37 (new compound) showed the outstanding activity (RF: 15.31) in reversing MDR in A549/Tax cells. Compound 37 could act as a substrate for P-gp and inhibit the efflux function of P-gp by competitively binding to the binding site of antitumor drugs. Meanwhile, the molecular docking results confirmed that compound 37 was identified to under-go high-affinity binding to the drug binding site of P-gp. In addition, 14 endogenous differential metabolites and 6 metabolic pathways involved closely associated with the reversal of tumor MDR effects of compound 37 were identified. (4) Conclusions: Overall, a new candidate compound 37 (24S-3-L-threonyl-Pyxinol) could be provided for reversing tumor MDR by this study.

Preprint ARTICLE | doi:10.20944/preprints202310.0009.v1

Schrödinger’s Cat May Be Dead All Along

Dhan Lord Fortela, Ashley Mikolajczyk

Subject: Computer Science And Mathematics, Analysis Keywords: network analysis; Hidden Markov Models

Online: 1 October 2023 (08:28:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0008.v1

Hydrazine Oxidation in Aqueous Solutions I. N4H6 Decomposition

Martin Breza, Alena Manova

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Coupled Cluster; geometry optimization; N-N bond splitting; QTAIM analysis; electron structure

Online: 1 October 2023 (08:18:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0020.v1

Development of Mathematical Models for Industrial Processes Using Dynamic Neural Networks

Srečko Herceg, Željka Ujević Andrijić, Nikola Rimac, Nenad Bolf

Subject: Engineering, Chemical Engineering Keywords: dynamic neural networks; industrial process; recurrent neural networks; long short-term memory

Online: 1 October 2023 (08:13:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0006.v1

Changes in Polar Lipid Composition in Balsam Fir during Seasonal Cold Acclimation and Relationship to Needle Abscission

Mason T. MacDonald, Rajasekaran R Lada, Gaye Elizabeth MacDonald, Claude D Caldwell, Chibuike C Udenigwe

Subject: Biology And Life Sciences, Plant Sciences Keywords: Abies balsamea; cold; conifer; fluorescence; galactosyldiacylglycerol; galactolipids; phospholipids; membrane injury; needle retention

Online: 1 October 2023 (08:11:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0012.v1

Therapeutic Approaches in Pulmonary Arterial Hypertension with Beneficial Effects on Right Ventricular Function – Preclinical Studies

André Balsa, Rui Adão, Carmen Brás-Silva

Subject: Biology And Life Sciences, Life Sciences Keywords: pulmonary arterial hypertension; pulmonary arterial banding; right ventricle; preclinical studies

Online: 1 October 2023 (08:01:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0005.v1

Association between Inflamatory Responses and Mitochondrial Dynamics in Salmonella Infection

Himanshi K, Ramendra Pati Pandey

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Mitochondria; immune response; activation; secretion; phagocytic

Online: 1 October 2023 (07:55:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0001.v1

Xenosialylation: Role in SARS/CoV-2 Post-infectious and Post-vaccination Complications and Common Cause of Hyperimmune/Autoimmune Diseases

Fiorella Carnevali, Sara Mangiaterra, Giacomo Rossi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: sialic acid; sialylation; xeno-sialic acid; COVID-19; SARS-CoV-2

Online: 1 October 2023 (07:28:10 CEST)

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The host glycosylation mechanism synthesizes the carbohydrates of glycoproteins of viral envelopes. Due to the loss of the Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase gene by some mammalian species, including humans (negative-CMAH), Neu5Gc is no longer synthesized. Uptake of Neu5Gc by negative-CMAH species, through the intake of food products derived from positive-CMAH mammals, leads to incorporating Neu5Gc-glycans in the glycocalyx (xenosialylation). Neu5Gc, being a Mammalian-associated Carbohydrate Antigen (MCA), acts as a non-self-antigen, inducing an inflammatory reaction (Xenosialitis), and triggering the production of circulating antiNeu5Gc antibodies to attack/remove all incorporated Neu5Gc. In the state of Xenosialitis, the virus-neutralizing antibodies produced by a heavily xenosialylated patient following exposure to viral infection (including SarsCoV2) or anti SarsCoV2 vaccination cross-react against all incorporated non-self Neu5Gc-MCA glycans due to their resemblance with viral envelope antigens synthesized by the host glycosylation mechanism. In addition, the circulating anti-XeSias antibodies determine the massive removal of the circulating neutralizing FC-xeno-contaminated antibodies by the serum, living only the hyper-inflammatory agalattosylated antiviral IgG antibodies. Therefore, we hypothesize that the combination of antibody cross-reaction against non-self Neu5Gc-MCA glycans and the massive removal of the xeno-contaminated newly formed neutralizing antibodies in favor of hyper reactive antibodies, could be the cause of the massive inflammatory reaction (cytokine storm, coagulopathies, neuropathies) observed in Covid 19 patients or after anti-SarsCoV2 vaccination. Therefore, evaluating the serum anti-MCA antibodies titer, particularly anti-Neu5GC antibodies, could be a groundbreaking tool to timely identify patients at risk of developing severe complications in case of all viral infections, including SARS-CoV2 and repeated vaccinations.

Preprint ARTICLE | doi:10.20944/preprints202310.0007.v1

Association between the Carbohydrate Quality Index (CQI) and Nutritional Adequacy in a Pediatric Cohort: The SENDO Project

Elise Fabios, MIGUEL ANGEL MARTINEZ-GONZALEZ, Lorena García-Blanco, Víctor de la O, Susana Santiago, Itziar Zazpe, Nerea Martin-Calvo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Carbohydrate quality index; CQI; Micronutrient Inadequacy; SENDO cohort

Online: 1 October 2023 (07:25:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0003.v1

Heterotrophy Compared to Photoautotrophy for Growth Characteristics and Pigment Compositions in Batch Cultures of Four Green Microagae

Thanh Tung Le, Amélie Corato, Thomas Gerards, Stéphanie Gérin, Claire Remacle, Fabrice Franck

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: microalgae; photoautotrophy; heterotrophy; growth; pigment content; photoacclimation; weak light effect

Online: 1 October 2023 (07:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0010.v1

Embedding Some Classes of Signed Graphs in the Line

Sattar Sattari

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: Signed graph; Valid drawing; Tree; Unicyclic graph; Ladder graph

Online: 1 October 2023 (07:17:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2180.v1

A New Screening Tool (BAMSA) for Sleep Apnea in Male Professional Truck Drivers

Riikka Huhta, Mariusz Sieminski, Kari Hirvonen, Eemil Partinen, Markku Partinen

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: sleep apnea; professional drivers; snoring; screening; sleep disordered breathing

Online: 1 October 2023 (07:15:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2179.v1

Development of a New Method for Measuring the Diameter of Iron Ore Pellets Using Digital Image Processing and Convolutional Neural Networks in Compliance with ISO 4698

Rafael M. Campos, Gustavo Maia De Almeida

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Convolutional Neural Networks; Computer Vision; Artificial Intelligence; Iron Ore Pellets; ISO 4698

Online: 1 October 2023 (07:12:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1848.v1

Description and Characterization of the Odontella aurita OAOSH22, a Marine Diatom Rich in Eicosapentaenoic Acid and Fucoxanthin, Isolated from Osan Harbor, Korea

Sung Min An, Kichul Cho, Eun Song Kim, Hyunji Ki, Grace Choi, Nam Seon Kang

Subject: Biology And Life Sciences, Aquatic Science Keywords: Carotenoid pigments; Fatty acids; Odontella aurita; Optimal growth condition; Ultrastructure; 18S rDNA

Online: 30 September 2023 (19:17:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2127.v1

Current Trends and Future Perspectives in the Remediation of Polluted Water, Soil and Air - A Short Review

Marin Ugrina, Antonija Jurić

Subject: Environmental And Earth Sciences, Environmental Science Keywords: water remediation; soil remediation; air remediation; pollution; environmental pollutants

Online: 30 September 2023 (18:15:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2125.v1

Wet-deposited TADF based OLED Active Layers: New Approaches Towards Further Optimization

Francisco Teixeira, José Carlos Germino, Luiz Pereira

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Solution deposited OLEDs; TADF; device structural defects; OLEDs charge balance; efficient OLED simple structure

Online: 30 September 2023 (18:13:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2124.v1

Effect of Photo Irradiation on Anaerobic Digestion of Waste Sewage Sludge-Reduced Methane and Hydrogen Sulfide Productions

Shotaro Toya, Shunsuke Iriguchi, Kohei Yamaguchi, Toshinari Maeda

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: anaerobic digestion; photo-fermentation; dark-fermentation; photo-irradiation; methane production; hydrogen sulfide consumption; waste sewage sludge

Online: 30 September 2023 (18:04:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2137.v1

Recent Optimization Methods and Techniques for Medical Image Analysis

jing wang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Medical image analysis, Medical image data, Deep learning, Computer vision techniques, Optimisation methods

Online: 30 September 2023 (17:58:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2114.v1

Prolonging Human Lifespan by Consciousness Integration or Brain Integration

Yaohua Xie

Subject: Biology And Life Sciences, Aging Keywords: Human; lifespan; aging; consciousness; brain; integration

Online: 30 September 2023 (17:55:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2126.v1

Periodic Flows in a Viscous Stratified Fluid in a Homogeneous Gravitational Field

Yuli D. Chashechkin, Artem A. Ochirov

Subject: Physical Sciences, Mathematical Physics Keywords: heterogeneous fluid; stratification; viscosity; compressibility; linear models; complete description; dispersion relations

Online: 30 September 2023 (10:54:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0094.v4

Exploring the Neurobiological Roots of Emotional Behavior in Tryptophan Metabolism: Insights from Novel Kynurenine Aminotransferase Knockout Mice

Ágnes Szabó, Eleonóra Spekker, Mónika Szűcs, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: posttraumatic stress disorder (PTSD); depression; anxiety; memory; tryptophan; serotonin (5-HT); kynurenine; transaminases; conversion disorder; experimental animal models

Online: 30 September 2023 (10:34:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2123.v1

A New Algorithm Using Support Vector Machines to Detect and Monitor Bloom-Forming Pseudo-nitzschia from OLCI Data

Luis Gonzalez Vilas, Evangelos Spyrakos, Yolanda Pazos, Jesus M Torres Palenzuela

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: OLCI; harmful algal blooms; Pseudo-nitzschia spp.; support vector machine; multi-spectral sensors; reflectance; Galician rias

Online: 30 September 2023 (10:31:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2122.v1

The Use of Spatially Multi-Component Plasma Structures and Combined Energy Deposition for High-Speed Flow Control. A Selective Review

Olga A. Azarova, Oleg V. Kravchenko

Subject: Engineering, Aerospace Engineering Keywords: supersonic/hypersonic flow control; energy source; bow shock wave; drag force; lift force; boundary layer; separation area; filamentary plasma; plasma actuator; Richtmyer–Meshkov instability; pulsing flow mode; damping flow pulsations

Online: 30 September 2023 (10:30:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2115.v1

Enhancing Maize Crop through Advanced Techniques: A Comprehensive Approach

Vikas Kumar Singh, Saksham Pundir, Deepti Chaturvedi, Arshdeep Kaur, Abhishek Pandey, Shreya Mandal, Rahul Kumar, Harish Pal Bhati, Ramesh Kumar Singh, Chittaranjan Kole, Prashant Kaushik

Subject: Biology And Life Sciences, Plant Sciences Keywords: Maize; Omics; Stresses; Resistance; Crop Improvement

Online: 30 September 2023 (10:26:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2162.v1

Numerical Investigation of the Effect of Free Flow Turbulence Intensity and Reynolds Number on the Heat Transfer Rate of Gas Turbine Blade with Internal Cooler

Sanaz Dehghaniyan

Subject: Engineering, Aerospace Engineering Keywords: heat transfer; gas turbine; turbulence intensity; Reynolds number; boundary layer

Online: 30 September 2023 (10:25:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2070.v1

Patel, Maitri; Oroszi, Terry (2023). Vaping-Associated Lung Injury. Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH. USA

Maitri Patel, Terry Oroszi

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Vaping; E cigarette; lung injury; lung disorder; association; relationship; adults; long term impact; vaping risk -benefit analysis; attitudes; mental health; side effect; EVALI

Online: 30 September 2023 (10:23:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2121.v1

A Process Concept of Waste-fired Zero Emission Integrated Gasification Magnetohydrodynamic Cycle Power Plant

Aiman Rashid, Marco Caredda

Subject: Engineering, Energy And Fuel Technology Keywords: magnetohydrodynamic; thermoacoustic; fuel cells; waste-fired power plant; zero emission power plant

Online: 30 September 2023 (10:21:28 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202309.2067.v1

Local Storytelling for a Climate-Friendly Future: An Evidence-Based Approach and First Prototyping Results from the Region of Lake Constance, Germany

Maike Sippel

Subject: Social Sciences, Other Keywords: Climate communication; storytelling; public engagement; climate action; sustainability

Online: 30 September 2023 (10:19:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2061.v1

Low Cost and Energy Efficient Hybrid Wireless Positioning System Using Wi-Fi and Bluetooth Technologies for Wearable Devices

Simon Renault, Akbar Sheikh-Akbari, Edward Ofoegbu

Subject: Engineering, Electrical And Electronic Engineering Keywords: indoor positioning system; Bluetooth; Wi-Fi; wearables; energy efficiency

Online: 30 September 2023 (10:17:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2068.v1

Demand-Oriented Review of Dynamic Energy Loss Monitoring System for Primary School Buildings through Micro-Environmental Data Monitoring and Occupant Behavior Analysis

Zhen Peng, Yanan Yu, Rui Guan

Subject: Engineering, Architecture, Building And Construction Keywords: school buildings; building dynamic energy loss; microenvironment; occupants’ behavior

Online: 30 September 2023 (10:16:05 CEST)

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