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Preprint ARTICLE | doi:10.20944/preprints202312.0281.v1

Metabolite Biomarkers for Early Ischemic Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model

Yulia Shevtsova, Natalia Starodubtseva, Alisa Tokareva, Kirill Goryunov, Alsu Sadekova, Irina Vedikhina, Tatiana Ivanetz, Oleg Ionov, Vladimir Frankevich, Egor Plotnikov, Gennady Sukhikh, Dmitry Zorov, Denis Silachev

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: metabolomics; amino acids; diagnostics; neonatal asphyxia; liquid chromatography–mass spectrometry; newborn screening

Online: 5 December 2023 (15:31:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0284.v1

A Deep Neural Network Ensemble Adjustment Kalman Filter and Its Application on Strongly Coupled Data Assimilation

Zheqi Shen, Renxi Wang

Subject: Oceanography, Environmental And Earth Sciences Keywords: Data assimilation; machine learning; deep neural network; ensemble Kalman filter; strongly coupled data assimilation

Online: 5 December 2023 (15:30:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0277.v1

Pre‐Clinical Study of Subunit Betulin‐Adjuvanted Tetravalent Candidate Influenza Vaccine: TetraFluBet

Irina Tcymbarevich, Anna Krasheninnikova, Aleksandr Ivanov, Marina Stukova, Ekaterina Romanovskaya-Romanko, Nataliya Mikhailova, Anton Belkin, Olga Belyakova, Alevtina Nicolaeva, Igor Krasilnikov

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: influenza vaccine; seasonal influenza; pandemic influenza; adjuvant; subunit vaccine; SARS-CoV-2; betulin

Online: 5 December 2023 (15:29:12 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0283.v1

Ventilation Management in a Patient with Ventilation-Perfusion Mismatch in the Early Phase of Lung Injury and During the Recovery

Ana Cicvaric, Josipa Glavas Tahtler, Tajana Turk, Sanda Škrinjarić Cincar, Despoina Koulenti, Nenad Neskovic, Mia Edl, Slavica Kvolik

Subject: Anesthesiology And Pain Medicine, Medicine And Pharmacology Keywords: Ventilation, pulmonary; Lung Injury; Personalized ventilation; Hypoxia; Pulmonary Diffusing Capacity; Intensive care; Pneumonia; Stenotrophomonas maltophilia

Online: 5 December 2023 (15:24:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0279.v1

Festival Recovery and Consumption Promotion Mechanism in the Post-pandemic Period: The case of the Qingdao International Beer Festival

Xinjie Zheng, Xiaoting Chi

Subject: Tourism, Leisure, Sport And Hospitality, Social Sciences Keywords: festival sustainability; destination familiarity; product familiarity; image; perceived value; satisfaction; loyalty intentions; visitor involvement

Online: 5 December 2023 (15:22:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0276.v1

An Overview on the Structure-Activity Relationship in Novel Antimicrobial Thiazoles Clubbed with Various Heterocycles (2017-2022)

Daniel Ungureanu, Brîndușa Tiperciuc, Cristina Nastasă, Ioana Ionuț, Gabriel Marc, Ilioara Oniga, Ovidiu Oniga

Subject: Medicinal Chemistry, Chemistry And Materials Science Keywords: thiazole; structure-activity relationship; antimicrobial; heterocycles; hybrid compounds

Online: 5 December 2023 (15:21:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0278.v1

Sustainable Space Tourism: What Can We do in Education from Economic and Environmental Perspectives?

Yize Wu, Kang-Lin Peng, Yijing Yao, Yanping Guo

Subject: Business And Management, Business, Economics And Management Keywords: Sustainable space tourism; economic development; environmental protection; education intervention; Chinese residents

Online: 5 December 2023 (15:19:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0268.v1

Stream Chemistry and Forest Recovery Assessment and Prediction Modeling in Coal Mine Affected Watersheds in Kentucky, USA

Buddhi Gyawali, Oguz Sariyildiz, George Fouad Antonious, Kenneth Semmens, Demetrio Zourarakis, Maya Bhatt

Subject: Environmental Science, Environmental And Earth Sciences Keywords: Appalachia; Coal mining; conductivity; reclamation; vegetation change; water quality

Online: 5 December 2023 (15:10:59 CET)

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: Kentucky is one of the largest coal producing states and surface coal mining has led to changes in natural land cover, soil loss, and water quality. This study explored relationships between actively mined and reclaimed areas and vegetation change and water quality parameters. The study site evaluated 58 watersheds with Landsat-derived variables (reclamation age, mining percentage, reclaimed forest percentage, and reclaimed woods percentage) as well as topographic variables (such as elevation, slope, drainage density, and infiltration). Water samples were collected in spring (n=9), summer (n=14), and fall (n=58) 2017 to study changes in water quality variables (SO42-, alkalinity, conductivity, Ca2+, Mg2+, Mn2+, Al3+, and Fe2+,Fe3+) in response to changes in land cover. Pearson correlation analyses indicated conductivity has strong to very strong relationships with other variables of water quality variables related to coal mining (except Al3+, Fe2+,Fe3+, Mn2+, elevation, slope, and drainage density) and land cover variables. In addition, separate multivariate regression analyses were performed with conductivity values based on samples collected in the fall. First, conductivity response to mining percentage, reclamation age and topographic variables were examined (adjusted R2=0.818, p < 0.01). Next, vegetation cover change parameters were added to the same model, which yielded slightly improved R2 (adjusted R2 = 0.826, p < 0.01). Finally, reclamation age and mining percentage were used to explain the quantity of reclaimed forested areas as a percentage of watersheds. The model was significant (p < 0.01) with an adjusted R2 value of 0.641. Results suggest that the quantity (area as a percentage) of reclaimed forests may be a predictor of mining percentage and reclamation age. This study indicated that conductivity is a predictable water quality indicator that is highly associated with Coal Mine Related Stream Chemistry in areas where agriculture and urban development are limited. These findings may help the scientific community and key state and federal agencies improve their understanding of water quality attributes in watersheds affected by coal mining as well as refining land reclamation practices.

Preprint ARTICLE | doi:10.20944/preprints202312.0233.v1

Hydrogen Sulfide (H₂S) Adsorption from Natural Gas Using Silver Modified 13X Molecular Sieve

Mirzokhid Abdirakhimov, Mohsen H. Al-Rashed, Janusz Wójcik

Subject: Chemical Engineering, Engineering Keywords: H₂S adsorption; 13X molecular sieve; adsorption capacity; ion exchange; silver modification

Online: 5 December 2023 (15:10:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0254.v1

Ultrafiltration Harvesting of Microalgae Culture Cultivated in a WRRF: Long-Term Performance and Techno-Economic and Carbon Footprint Assessment

Juan Francisco Mora-Sánchez, Josué González-Camejo, Guillermo Noriega-Hevia, Aurora Seco, Maria Victoria Ruano

Subject: Chemical Engineering, Engineering Keywords: Anaerobic digestion (AD); cross-flow; greenhouse gas (GHG) emissions; harvesting; Membrane photobioreactor (MPBR); microalgae; ultrafiltration (UF); water resource recovery facility (WRRF).

Online: 5 December 2023 (15:09:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0270.v1

Antimicrobial and Other Pharmacological Properties of Ocimum basilicum, Lamiaceae

Kairat Zhakipbekov, Aknur Turgumbayeva, Sholpan Akhelova, Kymbat Bekmuratova, Olga Blinova, Gulnara Utegenova, Klara Shertayeva, Nurlan Sadykov, Kuanysh Tastambek, Akzharkyn Saginbazarova, Kenzhebek Urazgaliyev, Gulbanu Tulegenova, Zere Zhalimova, Zhanylsyn Karasova

Subject: Pharmacy, Medicine And Pharmacology Keywords: Ocimum basilicum; antimaicrobaial; antiviral; antioxidant; anti-inflammatory

Online: 5 December 2023 (15:05:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0258.v1

A Novel Customised Load Adaptive Framework for Induction Motor Fault Classification Utilizing MFPT Bearing Dataset

Shahd Ziad M Hejazi, Michael Packianather, Ying Liu

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: Bearing Fault Classification; Load Variation; Wavelet Singular Energy (WSE); Machinery Fault Prevention Technology (MFPT) Dataset; Continuous Wavelet Transform (CWT); Load Dynamics; Customised Load Adaptive Framework (CLAF).

Online: 5 December 2023 (15:02:56 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0257.v1

Telomere length variation in model Bryophytes

Liia R Valeeva, Anastasia Sannikova, Nadiya R Shafigullina, Liliia R Abdulkina, Margarita Rashidovna Sharipova, Eugene V Shakirov

Subject: Plant Sciences, Biology And Life Sciences Keywords: TRF analysis; ITS; Physcomitrium; Ceratodon; Marchantia; Sphagnum; dioecious

Online: 5 December 2023 (15:01:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0255.v1

The Impact of the COVID-19 Pandemic on Diabetes Self-Management in Saudi Arabia

Ibrahim Sales, Ghada Bawazeer, Hadeel Alkofide, Hadeel Alkofide

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: COVID-19 Pandemic, Diabetes, DSMQ, Self-management, Saudi patients with diabetes

Online: 5 December 2023 (15:00:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0256.v1

Novichok Nerve Agents as Inhibitors of Acetylcholinesterase – In Silico Study of Their Non-covalent Binding Affinity

Rafał Madaj, Bartłomiej Gostyński, Arkadiusz Chworoś, Marek Cypryk

Subject: Organic Chemistry, Chemistry And Materials Science Keywords: Novichok; AChE; DFT; binding affinity

Online: 5 December 2023 (14:59:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0243.v1

The Rapidly Changing Patterns in Bacterial Co-infections Reveal Peaks in Limited Gram-Negatives during COVID and Their Sharp Drop Post- Vaccinations Implying Potential Evolution of Co-protection during Vaccine-Virus-Bacterial Interplay

Kamaleldin B. Said, Ahmed Alsolami, Khalid Farhan Alshammari, Fawwaz Alshammari, Safia Moussa, Mohammed H. Alghozwi, Suliman F. Alshammari, Nawaf F. Alharbi, Amany Mohammed Khalifa, Madiha Rabie Mahmoud, Mohamed E. Ghoniem

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Co-infections; COVID-19 fatality; molecular mimicry; pathogens

Online: 5 December 2023 (14:58:21 CET)

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The SARS-CoV-2 have caused a devastating pandemic of all times in the recent human history. However, there is a serious paucity in high quality data on aggravating factors and mechanisms of co-infection. This study aimed to identify the trending patterns of bacterial co-infections and types and associated outcomes in three phases of the pandemic. Using quality hospital data, we have investigated the SARS-CoV-2 fatality rates, profiles, and types of bacterial co-infections before, during, and after COVID-19 vaccinations. Out of 389 isolates used in different aspects, 298 was examined before and during the pandemic (n=149 before, n=149 during), death rates were 32% during compared to only 7.4% before pandemic with significant association (P value = 0.000000075). Death rate was 34% in co-infected (n = 170) compared to non-co-infected patients (n = 128) indicating a highly significant value (P value = 0.00000000000088). However, analysis of patients without other respiratory problems (n=28) indicated that among the remaining 270 patients, death was 30% in co-infected patients (n=150) and only 0.8% in non-coinfected (n=120) with high significant P value= 0.00000000076. The trending patterns of co-infections before, during, and after vaccinations showed a significant decline in Staphylococcus aureus with concomitant peaks in Gram-negatives in totals of (n= 149 before/n= 149 during): Klebsiella pneumonia (n = 11/49 before/during; E. coli n=10/24, A. baumannii n=8/25, and Ps. Aeruginosa n= 5/16, and S. aureus 13/1. Nevertheless, in post vaccination phase, (n= 91) gender-specific co-infections were examined for potential differences in susceptibility. Methicillin resistant S. aureus (MRSA) dominated both genders followed by E. coli in males and females with the latter gender showing higher rates of isolations in both species. Klebsiella pneumoniae declined to third place mostly in male patients. The drastic decline in K. pneumoniae and Gram-negatives post-vaccination strongly imply a potential co-protection in vaccines. Future analysis would gain more insights into molecular mimicry.

Preprint ARTICLE | doi:10.20944/preprints202312.0282.v1

Prokletijella montana, n. gen, n. sp., the First Leptodirini with Asymmetric Genitalia (Coleoptera, Leiodidae, Cholevinae)

Michel Perreau, Peter Hlaváč

Subject: Insect Science, Biology And Life Sciences Keywords: Asymmetric genitalia; Phylogeny; Prokletije Mts.; Taxonomy; Zoogeography

Online: 5 December 2023 (14:57:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0246.v1

A Comparison of Clinical Outcomes of Robot-Assisted and Conventional Laparoscopic Surgery

Storm Chabot, Jean of Calleja-Agius, Tim Horeman

Subject: Surgery, Medicine And Pharmacology Keywords: robotic surgery; laparoscopy; cholecystectomy; colectomy; hysterectomy; nephrectomy; prostatectomy

Online: 5 December 2023 (14:57:28 CET)

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Background: Robot-assisted laparoscopic surgery robot-assisted surgical system has gained significant popularity over open and laparoscopic interventions. However, given its high costs, it remains unclear what clinical advantages robot-assisted laparoscopic surgery offers over conventional laparoscopic surgery. Objective: This umbrella review aims to synthesize and compare the clinical outcomes of robot-assisted laparoscopic surgery versus conventional laparoscopic surgery for five surgical procedures. Inclusion criteria: All systematic reviews and meta-analyses published in the past five years that compared the clinical outcomes of conventional laparoscopic surgery and robot-assisted laparoscopic surgery for cholecystectomy, colectomy, hysterectomy, nephrectomy and/or prostatectomy were included. Methods: A systematic literature search was conducted in PubMed and Scopus. The quality of all included reviews was assessed with the AMSTAR 2 quality assessment tool. Each review’s study characteristics (and a list of primary sources) were extracted, along with the quantitative and qualitative data for the following ten clinical outcomes: blood loss, rate of conversion to open surgery, hospitalization costs, incisional hernia rate, intraoperative complication rate, postoperative complication rate, length of hospital stay, operative time, readmission rate and wound infection rate. Results: Fifty-two systematic reviews and (network) meta-analyses were included in this umbrella review, covering more than 1,288,425 patients from 1046 primary sources published between 1996 and 2022. The overall quality of the included reviews was assessed to be low or critically low. Robot-assisted laparoscopic surgery yielded comparable results as conventional laparoscopic surgery in terms of blood loss, conversion to open surgery rate, intraoperative complication rate, postoperative complication rate, readmission rate and wound infection rate for most surgical procedures. While the hospitalization costs of robot-assisted laparoscopic surgery were higher and the operative times of robot-assisted laparoscopic surgery were longer than conventional laparoscopic surgery, robot-assisted laparoscopic surgery reduced the length of hospital stay of patients in nearly all cases. Conclusion: Robot-assisted laparoscopic surgery achieved comparable results with conventional laparoscopic surgery for cholecystectomy, colectomy, hysterectomy, nephrectomy and prostatectomy based on ten clinical outcomes. Further research is needed to prove that robot-assisted laparoscopy is as safe and reliable as conventional laparoscopic surgery.

Preprint ARTICLE | doi:10.20944/preprints202312.0239.v1

Quantifying the Impact of Rainfall Categories on Dengue Occurrence: A Multi-Site Analysis in India

Parthasarathi Barik, Prashant Goswami

Subject: Public, Environmental And Occupational Health, Public Health And Healthcare Keywords: Dengue occurrence; dengue control; dengue and heavy rainfall; dengue and rainfall categories; dengue and climate change

Online: 5 December 2023 (14:56:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0249.v1

Molecular Basis of Mullerian Agenesis Causing Congenital Uterine Factor Subfertility- a Systematic Review

Rajani Dube, Subhranshu Sekhar Kar, Malay Jhancy, Biji Thomas George

Subject: Obstetrics And Gynaecology, Medicine And Pharmacology Keywords: Mullerian agenesis (MA); Uterine aplasia; Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome; Uterine agenesis; Molecular; Genetics

Online: 5 December 2023 (14:55:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0271.v1

Influence of Salting on Physicochemical and Sensory Parameters of Blue-Veined Cheeses

María Eugenia Tornadijo Rodríguez, Noemí López González, Patricia Combarros-Fuertes, Bernardo Prieto Gutiérrez, Daniel Abarquero Camino, José María Fresno

Subject: Food Science And Technology, Biology And Life Sciences Keywords: Blue veined cheese; Salting; Salt/moisture ratio; Sensorial; Texture; Water activity

Online: 5 December 2023 (14:53:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0240.v1

Antibiotic Use in Primary Care in Northern Ireland

Heather Coleman, Naomi Hadnett

Subject: Pharmacy, Medicine And Pharmacology Keywords: :Antimicrobial use; antimicrobial resistance, COVID-19, pharmacists, primary care.

Online: 5 December 2023 (14:52:26 CET)

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Research is scarce regarding antimicrobial use and antimicrobial resistance (AMR) for specific localities in Northern Ireland (NI). Additionally, the effects of COVID-19 on antimicrobial pre-scribing patterns and AMR are unknown. Between the European Union (EU) and United States (US), AMR causes approximately 68,000 deaths annually. This study will provide a better understanding of antimicrobial use and prescribing patterns in Belfast and link with AMR. An electronic survey was developed and distributed to eighty-five community pharmacists in Belfast. Yearly and monthly prescription data was gathered from the Business Services Organisation and COVID-19 statistics from Gov.uk. All data was analysed on Microsoft Office Excel® and IBM® SPSS® Statistics 25. Overall response rate was 46%. Most pharmacists (82%) failed to address prescriber non-compliance with guidelines and antimicrobial dosing errors (59%). The most common in-dication for antibiotics was upper respiratory tract infections (URTIs). Overprescribing of anti-biotics was perceived as the leading cause of AMR, therefore 69% of pharmacists indicated in-creased General Practitioner (GP) compliance with guidelines would reduce AMR. Pharmacists’ are in an ideal position to reduce AMR through patient education however, it is demonstrated that pharmacists failed to adequately counsel patients on antibiotic use. All GP practices demonstrated inappropriate antibiotic use, especially for URTIs which suggests antibiotic appropriateness should be reviewed. Many patients avoided contact with GP’s during COVID-19 which may have resulted in reduced antibiotic use. This research established amoxicillin as the most commonly prescribed antibiotic, which is contributing to increased AMR with its broad-spectrum activity and has recognised a decrease in antibiotic prescribing during COVID-19. Based on the results found and a critical review of the literature it is recommended antimicrobial guidelines should be re-viewed and improved, enhanced training should be provided to pharmacists and the antibiotic guardian (AG) campaign should be reenergised.

Preprint ARTICLE | doi:10.20944/preprints202312.0242.v1

The Genera Platorchestia and Demaorchestia (Amphipoda, Talitridae, Talitriinae) from Seashores of Japan

Hiroshi Morino

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Platorchestia; Demaorchestia; intraspecific variation; Japan

Online: 5 December 2023 (14:51:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0236.v1

Use of Chia as a Binder to Obtain Chewable Tablets Containing Quinoa for Dietary Fiber Supplementation

Rosana Pereira Da Silva, Fanny Judhit Vereau Reyes, Josiane Souza Pereira Daniel, Julia Estevam da Silva Pestana, Samara de Almeida Pires, Humberto Gomes Ferraz

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: Quinoa; Chia; Fibers; Granulation Point; chewable tablets; Chia Mucilage

Online: 5 December 2023 (14:50:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0234.v1

High-performance strain sensor for detection of human motion and subtle strain based on liquid metal microwire

He Zhu, Zheng Sun, Xin Wang, Hong Xia

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: liquid metal nanoparticles; strain sensor; microwire; laser direct writing

Online: 5 December 2023 (14:48:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0232.v1

Leveraging Artificial Intelligence and Provenance Blockchain Framework to Mitigate Risks in Cloud Manufacturing in Industry 4.0

Mifta Ahmed Umer, Elefelious Getachew Belay, Luis Borges Gouveia

Subject: Safety, Risk, Reliability And Quality, Engineering Keywords: Provenance; Blockchain; Smart Contract; Predictive Auditing; Cloud Manufacturing Risks; Industrial Internet of Things

Online: 5 December 2023 (14:47:39 CET)

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.Cloud manufacturing is an evolving networked framework that enables multiple manufacturers to collaborate in providing a range of services, including design, development, production, and post-sales support. The framework operates on an integrated platform encompassing a range of Industry 4.0 technologies, such as Industrial Internet of Things (IIoT) devices, cloud computing, Internet communication, big data analytics, artificial intelligence, and blockchains. The connectivity of industrial equipment and robots to Internet opens the cloud manufacturing to the massive attack surface of cybersecurity and cyber crime threats caused by external and internal attackers. The impacts can be severe because physical infrastructure of industries is at stake. One potential method to deter such attacks involves utilizing blockchain and artificial intelligence to track the provenance of IIoT devices. This research explores a practical approach to achieve this goal by gathering provenance data associated with operational constraints defined in smart contracts and identifying deviations from these constraints through predictive auditing using artificial intelligence. A software architecture comprising IIoT communications to machine learning for comparing the latest data with the predictive auditing outcomes and logging appropriate risks was designed, developed, and tested. The state changes in the smart ledger of smart contracts were linked with the risks such that the blockchain peers can timely detect high deviations and take actions. The research defined the constraints related to physical boundaries and weight lifting limits allocated to three forklifts and showcased the mechanisms of detecting risks of breaking these constraints with the help of artificial intelligence. It also demonstrated state change rejections by blockchains at medium and high-risk levels. This research followed software development in Java 8 using JDK 8, CORDA blockchain framework, and Weka package for random forest machine learning. As a result of this, the model, along with its design and implementation, has the potential to enhance efficiency and productivity, foster greater trust and transparency in the manufacturing process, booster risk management, strengthen cybersecurity, and advance sustainability efforts.

Preprint ARTICLE | doi:10.20944/preprints202312.0272.v1

Valorization of “La Palma” Volcanic Ash for Making Portlandblended, Alkaline and Hybrid Portland-Alkaline Cements

Pablo Martin Rodríguez, Ana Fernández-Jiménez, María del Mar Alonso, Angel Palomo, Ines Garcia-Lodeiro

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: volcanic fly ash; blended cement; hybrid alkaline cement; alkaline cement

Online: 5 December 2023 (14:47:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0237.v1

Milestones in Antiviral Drug Development

Erik Desiré De Clercq

Subject: Epidemiology And Infectious Diseases, Medicine And Pharmacology Keywords: HIV; HBV; HSV; VSV; CMV; AIDS; ANPs; NRTIs; NtRTIs; NNRTIs

Online: 5 December 2023 (14:46:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0269.v1

Effects of Probiotic Lactoplantibacillus plantarum on Growth Performance, Antioxidant Capacity, Immune Function, and Cecal Microbiota in Broiler Chicken

Caimei Yang, Shuting Wang, Qing Li, Ruiqiang Zhang, Yinglei Xu, Jie Feng

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Lactoplantibacillus plantarum; broiler; growth performance; immune function; cecal microbiota

Online: 5 December 2023 (14:45:22 CET)

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This research is aimed to investigate the effects of Lactoplantibacillus plantarum (L. plantarum) on growth performance, oxidation resistance, immunity, as well as cecal microbiota in broilers. This work classed three hundred and sixty 1-day-old broilers as three groups randomly, including control (CON, basal diet), antibiotic (ANT, 75 mg kg-1 chlortetracycline added into basal diet), or probiotic group (LP, 5×108 CFU kg-1 Lactoplantibacillus plantarum HJLP-1 contained within basal diet). Animal were then fed for 42 days, and each group consisted of 15 broilers for 8 replicates. Compared with CON, L. plantarum supplementation significantly improved the average weight daily gain (AWDG) (P < 0.05) while reducing feed-to-gain ratio over the entire supplemental period (P < 0.05). Birds fed L. plantarum had marked lower serum ammonia and xanthine oxidase levels (P < 0.05) than those in ANT and CON. Significant improvements (P < 0.05) of superoxide dismutase, catalase, serum IgM and IgY contents in broilers fed L. plantarum were also observed when compared those in CON and ANT groups. Both L. plantarum and antibiotics decreased the pro-inflammatory factor IL-1β level significantly (P < 0.05), while only L. plantarum promoted the anti-inflammatory factor IL-10 level dramatically in the serum (P < 0.05) compared with CON. The L. plantarum dramatically (P < 0.05) increased acetic acid and butyric acid concentrations in the cecal contents，when compared to those in CON and ANT. Among the differences revealed by 16S rRNA analysis, L. plantarum markedly improved the community richness of cecal microbiota. At the genus level, butyric acid-producing bacteria Ruminococcus and Lachnospiraceae were found in higher relative abundance in samples of L. plantarum treated birds. In conclusion, dietary L. plantarum supplementation promoted the growth and health of broilers, likely by inducing a shift in broiler gut microbiota toward short-chain fatty acid (SCFA)-producing bacteria. Therefore, L. plantarum has tremendous potential as an alternative for antibiotics in poultry breeding.

Preprint ARTICLE | doi:10.20944/preprints202312.0248.v1

Blast-resistant Performance of Steel Petrochemical Control Room with 3D-Kagome Sandwich Wall

Zhijun Li, Xinlong Dong, Dou Chen, Xuehua Li

Subject: Civil Engineering, Engineering Keywords: vapor clouds explosion; petrochemical control room; 3D-Kagome; truss core sandwich wall; blast resistant performance

Online: 5 December 2023 (14:45:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0244.v1

Translational Relevance of Advanced Age and Atherosclerosis in Preclinical Trials of Biotherapies for Peripheral Artery Disease

Keith A Webster

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: gene therapy; cell therapy; peripheral artery disease; critical limb ischemia; clinical trials

Online: 5 December 2023 (14:44:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0252.v1

Influence of Adherence to the Mediterranean Diet on Assisted Reproductive Techniques Outcomes: A Systematic Review

Laura Martín-Manchado, Miriam Sanchez-SanSegundo, Antonio Manuel Moya-Yeste, Jose Antonio Hurtado-Sanchez, Ana Zaragoza-Martí

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: mediterranean diet; assisted reproductive techniques; infertility; in vitro fertilization; artificial insemination

Online: 5 December 2023 (14:43:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0262.v1

Long-Term Functional Limitations on Cardiopulmonary Exercise Testing in Emotions-Triggered Takotsubo Syndrome

Jean Pierre Jabbour, Luca Arcari, Luca Cacciotti, Damiano Magrì, Tommaso Recchioni, Livia Valeri, Enrico Maggio, Carmine Dario Vizza, Roberto Badagliacca, Silvia Papa

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Cardiopulmonary exercise test; Takotsubo syndrome; Long-term functional limitations; Heart failure

Online: 5 December 2023 (14:40:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0259.v1

Evaluation of an Adaptive Soil Moisture Bias Correction Approach in the ECMWF Land Data Assimilation System

David Fairbairn, Patricia De Rosnay, Peter Weston

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: satellite; soil moisture; data assimilation; bias-correction

Online: 5 December 2023 (14:37:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0250.v1

Membrane-Associated Ubiquitin Ligase RNF152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C.J.M.D.S. Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Subject: Cell And Developmental Biology, Biology And Life Sciences Keywords: lysosome; melanogenesis; melanosome; RNF152; tyrosinase; ubiquitin ligase

Online: 5 December 2023 (14:33:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0264.v1

NH2-MIL-125-Derived TiO2@N-Doped C Visible Light Catalyst for Wastewater Treatment

Wenbing Wang, Wei Qiang, Chuntao Chen, Dongping Sun

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: Titanium dioxide; NH2-MIL-125; N/TiO2@C; Visible light photocatalysis; Wastewater Pollutants

Online: 5 December 2023 (14:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0280.v1

Rare Earth (La, Pr and Sm) Doped Sr1‐yCo1‐xFexO3 as Cathode in SOFC

Selene Díaz-González, Roberto Campana, Rocío Andújar, Adrián Pardo, Beatriz Gil-Hernández, Antonio D. Lozano-Gorrín

Subject: Ceramics And Composites, Chemistry And Materials Science Keywords: perovskite; solid state; rare earth; Rietveld refinement; SOFC

Online: 5 December 2023 (14:26:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0253.v1

Enhancement of Lycopene Synthesis by Brassica trispora by Low Frequency Alternating Magnetic Field

Wang Hong, Hou Jiayang, Wang Dongxu, Yang Maohua, Jinlong Liu

Subject: Food Science And Technology, Biology And Life Sciences Keywords: magnetic field; lycopene; Brassica trispora; transcriptome; reactive oxygen species

Online: 5 December 2023 (14:24:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0273.v1

Optimized Cuffless Blood Pressure Measurement Using ECG, PPG and Linear Regression

Francesca Boschi, Valeria Figini, Guido Pagana, Monica Visintin

Subject: Bioengineering, Engineering Keywords: ECG; PPG; Pulse transit Time; Heart rate; Blood pressure; Denoising; Regression analysis

Online: 5 December 2023 (14:23:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0247.v1

Adsorption of Uranium (VI) from Aqueous Solution Using Melamine Formaldehyde Organo Clay Nanocomposite Foam as a Novel Adsorbent

Ahmet Gürses, Arvin Sehhatigdiri, Demet Yılmaz, Elif Şahin

Subject: Nanotechnology, Chemistry And Materials Science Keywords: Radioactive substance; Nanocomposite; Adsorption; Melamine formaldehyde; Adsorbent

Online: 5 December 2023 (14:22:36 CET)

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Abstract: Uranium is a toxic radioactive element and is usually found in the environment in hexavalent form. It has become a necessity to remove uranium, which can enter the environment in excessive amounts through nuclear industrial activities, from access waters. Melamine formaldehyde organo clay nano composite foam (MFCNCF) was prepared as a novel adsorbent by hardening with thermal treatment. Structural, crystallographic textural and surface morphological characterization of the prepared adsorbent was made by FTIR and XRD spectroscopic and SEM and HRTEM microscopic techniques. This study aims to investigate the adsorption of U(VI) from aqueous solution by MF organo clay nanocomposite and its dependence on various variables such as initial uranium concentration, adsorption time, adsorbent dosage, initial pH, and temperature. Additionally, adsorption isotherm analysis and adsorption kinetics and thermodynamics were also examined. For this purpose, the batch adsorption experiments were carried out and the equilibrium concentration of U(VI) in the aqueous solution was measured with a UV-Vis spectrophotometer at a wavelength of 433 nm, which corresponds to its maximum absorptivity. The results regarding adsorption kinetics show that 30 min is sufficient to reach adsorption equilibrium and the data show a high fit to the pseudo-second-order kinetic model. Isotherm analysis also revealed a high fit of the data to the Type III isotherm and the Halsey model. Based on this fit, an adsorption mechanism involving two regions (electrostatic and complex formation) was proposed for the current adsorption system. The adsorption isosteric enthalpy and entropy values for the first and second regions are 3.65 and -51.02kJ/mol and 1.77 and -167.28J/mol, respectively. It was found in kmol. Experimental results showed that the prepared nanocomposite foam adsorbent is an effective and potential alternative for the effective removal of U(VI) from aqueous solutions.

Preprint ARTICLE | doi:10.20944/preprints202312.0241.v1

Investigation on the Influence Area of Excavation of Double-Line Highway Tunnel Underpass Existing Railway Tunnel

Yifan Li, Changfu Huang, Hongjian Lu, Chao Mou

Subject: Other, Environmental And Earth Sciences Keywords: double-line highway tunnel; oblique passing under; area of influence; numerical simulation; tunnel dynamic and static loads

Online: 5 December 2023 (14:13:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0245.v1

Objective Priors for Invariant e-Values in the Presence of Nuisance Parameters

Elena Bortolato, Laura Ventura

Subject: Probability And Statistics, Computer Science And Mathematics Keywords: Asymptotic expansions; Adjusted score function; Bias reduction; Evidence; Full Bayesian Significance test; Higher-Order asymptotics; Matching priors; Median bias reduction

Online: 5 December 2023 (14:10:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0275.v1

Calculation of the Three Partition Coefficients logPow, logKoa and logKaw of Organic Molecules at Standard Conditions at Once by Means of a Generally Applicable Group-Additivity Method

Rudolf Naef, William E. Acree, Jr.

Subject: Physical Chemistry, Chemistry And Materials Science Keywords: group-additivity method; Gauss-Seidel diagonalization; partition coefficient; logPow; logKoa; logKaw

Online: 5 December 2023 (13:18:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0274.v1

Active and Intelligent Biodegradable Packaging Based on Anthocyanins for Preservation and Monitoring Rich Protein Foods

Bifen Zhu, Yu Zhong, Danfeng Wang, Yun Deng

Subject: Polymers And Plastics, Chemistry And Materials Science Keywords: Food packaging; Anthocyanins; Biodegradable materials; Food quality

Online: 5 December 2023 (13:05:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0266.v1

Tracing Geographic and Molecular Footprints of Copepod Crustaceans Causing Multifocal Purple Spots Syndrome in the Caribbean Sea Fan Gorgonia ventalina

Oksana A. Korzhavina, Mikhail A. Nikitin, Bert W Hoeksema, Maickel Armenteros, James D. Reimer, Viatcheslav N. Ivanenko

Subject: Life Sciences, Biology And Life Sciences Keywords: parasites; gorgonian octocorals; integrative taxonomic approach; phylogenetic analysis; Caribbean region; copepod crustaceans; Lamippidae

Online: 5 December 2023 (11:44:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0267.v1

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

Elber Osorio-Rodríguez, Dairo Rodelo-Barrios, Carlos Rebolledo-Maldonado, Alberto Polo-Barranco, Jhonny Patiño-Patiño, Mauricio Aldana-Roa, Valeria Sánchez-Daza, Emily Sierra-Ordoñez, Alfonso Bettin-Martínez

Subject: Tropical Medicine, Medicine And Pharmacology Keywords: leptospirosis; acute kidney injury; renal replacement therapy; zoonotic disease; antibiotic; death

Online: 5 December 2023 (11:43:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0263.v1

Cancer‐Associated Fibroblast Heterogeneity in Oral Cancer

Julia Arebro, Che-Min Lee, Kevin L Bennewith, Cathie Garnis

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: Cancer‐associated fibroblast, CAF subtype, oral squamous cell carcinoma, tumor microenvironment

Online: 5 December 2023 (11:11:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0238.v1

From Microscale Interactions to Macroscale Patterns in Copepod-Crinoid Symbiosis

Oksana A. Korzhavina, Natalia V. Gubareva, Andrey V. Kitashov, Temir A. Britayev, Viatcheslav N. Ivanenko

Subject: Aquatic Science, Biology And Life Sciences Keywords: Copepod Associations; Symbiotic Relationships; Crinoids; Comatulida; Marine Biodiversity; Marine Ecology; Marine Invertebrates; Host-Symbiont Interactions; Marine Parasitology

Online: 5 December 2023 (11:08:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0261.v1

Effect of Caffeine Supplementation in Women Volleyball Players on Performance and Wellness during a Regular Training Week

Jesús Siquier-Coll, Gabriel Delgado-García, Fulgencio Soto-Méndez, Antonio Liñán-González, Raquel García, Francisco Tomás González-Fernández

Subject: Nursing, Public Health And Healthcare Keywords: supplementation; caffeine; sport perfomance; volleyball; ergogenic aids.

Online: 5 December 2023 (11:01:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0260.v1

Topological Data Analysis in Cardiovascular Signals: An Overview

Enrique Hernández-Lemus, Pedro Miramontes, Mireya Martinez-Garcia

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: topological data analysis; cardiovascular signals; alegbraic topology; persistent homology; mapper algorithm

Online: 5 December 2023 (11:00:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0235.v1

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

Mauro Di Ianni, Carmine Liberatore, Nicole Santoro, Paola Ranalli, Francesco Guardalupi, Giulia Corradi, Ida Villanova, Barbara Di Francesco, Stefano Lattanzio, Cecilia Passeri, Paola Lanuti, Patrizia Accorsi

Subject: Primary Health Care, Public Health And Healthcare Keywords: GvHD; GvL; TCR alpha-beta; CD45RA; Tregs; NK; Suicide gene; immunotherapies

Online: 5 December 2023 (09:18:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0512.v8

Black Hole Construction from the Minkowski Manifold

Christopher Laforet

Subject: Theoretical Physics, Physical Sciences Keywords: Black holes; General Relativity; Schwarzschild metric

Online: 5 December 2023 (09:16:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0231.v1

Why is Abiogenesis Such a Tough Nut to Crack?

David Lynn Abel

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: protolife; protocells; abiogenesis; life origin; origin of life; protometabolism; protocellular metabolomics

Online: 5 December 2023 (09:05:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0187.v1

Law of Variability in Science Driving Technological Evolution

Mario Coccia

Subject: Other, Social Sciences Keywords: Quantum technology; Research fields; Science dynamics; Research topics; Entropy; Variance decomposition; Technological evolution; Variation; Generalized Darwinism; Technological change

Online: 5 December 2023 (07:45:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0184.v1

Integrated Waste-to-Energy Process Optimization for Municipal Solid Waste

Hossam A.Gabbar, Muhammad Sajjad Ahmad

Subject: Energy And Fuel Technology, Engineering Keywords: Process optimization; Waste conversion; Life cycle analysis; Machine learning

Online: 5 December 2023 (07:43:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0196.v1

Influence of the Thermal Insulation Thickness of Walls on the Heating Demand of an Existing Dwelling

Sebastian George Maxineasa, Dorina Nicolina Isopescu, Ioana Roxana Baciu, Alexandra Cojocaru, Ligia Mihaela Moga

Subject: Civil Engineering, Engineering Keywords: natural environment; construction sector; sustainable development; energy performances; existing buildings; heating demand

Online: 5 December 2023 (07:41:23 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202312.0138.v1

Numbers, Facts and Methods, State-of-the-Art, Current Trends and Evaluation of Arguable Claims and Statements — A 2024 Overview

Tim Ziemer

Subject: Other, Engineering Keywords: research; science; engineering; state-of-the-art; outlook

Online: 5 December 2023 (06:20:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0161.v1

Haemolytic Anaemia-Related Pulmonary Hypertension

Panagiotis K Karyofyllis, Eftychia A Demerouti, Eleftheria-Garyfallia N Tsetika, Styliani G Apostolopoulou, Panagiotis D Tsiapras, Ioannis Iakovou, Dimitrios P Tsiapras

Subject: Pulmonary And Respiratory Medicine, Medicine And Pharmacology Keywords: Pulmonary Hypertension; Haemolytic anemia; Haematological Disorders; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension; Balloon Pulmonary Angioplasty

Online: 5 December 2023 (06:18:52 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202312.0126.v1

Organic Growth Theory for Global Sustainable Competitiveness and COVID-19 Sensitivity Analysis

Ahmad Karnama

Subject: Other, Business, Economics And Management Keywords: sustainability; sustainable development goals; organic growth theory

Online: 5 December 2023 (06:15:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0160.v1

An Insight into Kounis Syndrome: Bridging Clinical knowledges with Forensic Perspectives

Elena Forzese, Claudia Pitrone, Vincenzo Cianci, Daniela Sapienza, Antonio Ieni, Lorenzo Tornese, Alessio Cianci, Patrizia Gualniera, Alessio Asmundo, Cristina Mondello

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Kounis syndrome; anaphylaxis; postmortem; immunohistochemistry; biochemistry; tryptase; acute coronary syndrome.

Online: 5 December 2023 (06:13:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0136.v1

Impact of CytoSorb Hemoadsorption Therapy on Fluid Balance in Patients with Septic Shock

Klaus Kogelmann, Tobias Huebner, Matthias Drüner, Dominik Jarczak

Subject: Clinical Medicine, Medicine And Pharmacology Keywords: Inflammation; septic shock; CytoSorb; hemoadsorption; fluid balance; vasopressors; vascular barrier function; endothelial integrity

Online: 5 December 2023 (06:12:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1864.v2

UV-C Light Intervention as a Barrier against Airborne Transmission of SARS-CoV-2

Izabela Ragan, Jessie Perez, Lindsay Hartson, Wilson Davenport, Branden Doyle

Subject: Virology, Biology And Life Sciences Keywords: SARS-CoV-2; transmission; respiratory; viruses; healthcare; sterilization; air; hamster model; UV-C light; inactivation

Online: 5 December 2023 (06:12:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0162.v1

Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidn-3-Sambubiosidin, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay

Sergio Raúl Zúñiga-Hernández, Trinidad García-Iglesias, Monserrat Macías-Carballo, Alejandro Pérez-Larios, Yanet Karina Gutiérrez-Mercado, Gabriela Camargo-Hernández, Christian Martin Rodríguez-Razón

Subject: Dietetics And Nutrition, Medicine And Pharmacology Keywords: Delphinidin-3-sambubiosid; Quercetin; Hibiscus Acid; Bioinformatics; Hibiscus sabdariffa

Online: 5 December 2023 (06:11:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0129.v1

Effect of an Environment-Friendly Depressant on the Flotation of Bastnaesite and Fluorite

Chunlei Guo, Shaochun Hou, Weiwei Wang, Qiang Li

Subject: Mining And Mineral Processing, Engineering Keywords: Bastnaesite; Fluorite; Sodium alginate; Flotation

Online: 5 December 2023 (06:11:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0131.v1

Factors Affecting Properties of Polymer Grouted Sands

Costas Anagnostopoulos, Vassilios Aggelidis

Subject: Civil Engineering, Engineering Keywords: epoxy resin; grout; creep; strength; permeability; porosity; regression analysis

Online: 5 December 2023 (06:08:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0221.v1

Cheminformatics-Based Design and Synthesis of Hydroxyapatite/Collagen Nanocomposites for Biomedical Applications

Mohamed Aaddouz, Khalil Azzaoui, Rachid Sabbahi, Meryem Idrissi Yahyaoui, Abdeslam Asehraou, Moulay hfid Youssoufi, Mohamed El Miz, Belkheir Hammouti, Sergey Shityakov, Mohamed Siaj, Elmiloud Mejdoubi

Subject: Biomaterials, Chemistry And Materials Science Keywords: antimicrobial; bioavailability; biocomposite; collagen; co-precipitation; hydroxyapatite

Online: 5 December 2023 (06:06:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0229.v1

Vector-Borne Zoonotic Lymphadenitis – the Causative Agents, Epidemiology, Diagnostic Approach and Therapeutic Possibilities – An Overview

Martina Oršolić, Nikolina Bogdanić, Mirjana Balen Topić

Subject: Epidemiology And Infectious Diseases, Medicine And Pharmacology Keywords: vector-borne; zoonosis; lymphadenitis; tick; diagnosis; therapy

Online: 5 December 2023 (06:05:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0215.v1

Geochemical and Mineralogical Features of Triassic Dolomites From the Area of Upper Silesia in Poland

Katarzyna J. Jadwiga Stanienda-Pilecki, Rafał Jendruś

Subject: Geography, Environmental And Earth Sciences Keywords: dolomites; microscopic analysis; X-Ray Diffraction; X-Ray Fluorescence; Electron microprobe analysis; geochemical properties

Online: 5 December 2023 (06:03:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0206.v1

E3 Ligases Regulate Organelle Inheritance in Yeast

Keisuke Obara, Kohei Nishimura, Takumi Kamura

Subject: Cell And Developmental Biology, Biology And Life Sciences Keywords: ubiquitin; E3 ligase; proteolysis; vacuole; mitochondria; peroxisome; myosin; yeast

Online: 5 December 2023 (04:48:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0230.v1

Environmental Impacts of Crops Production Systems in Subtropical Plateau Regions: Case Study of Yunnan, China

Yousheng He, Dan Mao, Wei Zhang, Qi Huang, Yuan Wang, Xinping Chen, Xiangshu Dong, Zhi Yao

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: subtropics; plateau region; environmental impact; life cycle assessment

Online: 5 December 2023 (04:47:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0204.v1

Professional Quality of Life, Job Satisfaction, and Intention to Leave Among Psychiatric Nurses

Shaher Hamaideh, Abdallah Abu Khait, Hanan Al-Modallal, Rami Masa'deh, Ayman Hamdan-Mansour, Mohammed AlBashtawy

Subject: Nursing, Public Health And Healthcare Keywords: ProQoL; job satisfaction; intention to leave; psychiatric nurses; Jordan

Online: 5 December 2023 (04:46:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0121.v1

Assessment of Full-Fat Tenebrio molitor as Feed Ingredient for Solea senegalensis: Effects on Growth Performance and Lipid Profile

Ismael Hachero Cruzado, Monica B. Betancor, Antonio Jesús Coronel Dominguez, Manuel Manchado, Francisco Javier Alarcón-López

Subject: Aquatic Science, Biology And Life Sciences Keywords: Tenebrio molitor; insect meal; sustainable protein sources, Solea senegalensis, fatty acids profile

Online: 5 December 2023 (04:44:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0213.v1

Clinical Application of the Association Between Genetic Alteration and Intraoperative Fluorescence Activity of 5-Aminolevulinic Acid During the Resection of Brain Metastasis of Lung Adenocarcinoma

Hyeon Yeong Jeong, Won Jun Suh, Kim Seung Hwan, Nam Taek Min, Ji Hwan Jang, Kim Kyu Hong, Seok Hyun Kim, Young Zoon Kim

Subject: Life Sciences, Biology And Life Sciences Keywords: brain metastasis; lung cancer; 5-aminolevulinic acid; genetic alteration; next-generation sequencing; infiltration; cell cycle regulation; proliferation

Online: 5 December 2023 (04:44:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0135.v1

Estimating Water Balance at Beterou Watershed, Benin Using Soil and Water Assessment Tool (SWAT) Model

Ella Sèdé Maforikan, Ali Hammani, Maurice D. Ahouansou, Christian Anthony-Krueger

Subject: Civil Engineering, Engineering Keywords: Watershed; water balance; SWAT modelling; Beterou

Online: 5 December 2023 (04:43:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0189.v1

Nutritional Status and Physical Activity are Associated with Cognitive Function in Chinese Community-Dwelling Older Adults: the Role of Happiness

Jianghong Liu, Michael Pan, McKenna Sun, Haoer Shi, Rui Feng

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: cognitive decline; physical activity; nutritional status; happiness; aging; diet

Online: 5 December 2023 (04:43:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0128.v1

An Overview of Kerr Blackhole

Santosh Ballav Sapkota

Subject: Theoretical Physics, Physical Sciences Keywords: Kerr metric; Boyer-Lindquist co-ordinate; event horizon

Online: 5 December 2023 (04:41:17 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0117.v1

Acute Aortic Stent-Graft Thrombosis in Patient with Recent COVID-19 Infection

Antonio Marzano, Jihad Jabbour, Vincenzo Brizzi, Enrico Sbarigia, Simone Cuozzo

Subject: Surgery, Medicine And Pharmacology Keywords: EVAR; COVID-19; stent-graft thrombosis; explantation

Online: 5 December 2023 (04:40:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0118.v1

Syntax-driven Target Opinion Word Extraction

Roggie Terry, Prenate Cress, Woods Ali

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Aspect-based Sentiment Analysis; Syntax Knowledge

Online: 5 December 2023 (04:39:35 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0211.v1

Strategic Investigation of Ligands for Melanoma Therapy: Docking Analysis and Predictive Toxicity Assessment

Ivan Vito Ferrari

Subject: Primary Health Care, Public Health And Healthcare Keywords: ; Melanoma; pKCSM; Docking approach; Diosmin; MAGEB1

Online: 5 December 2023 (04:39:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0216.v1

Innovative Strategies for Sustainable Dairy Farming in Canada amidst Climate Change

Suresh Neethirajan

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Climate Change; Dairy Farming; Methane Emissions; Sustainable Practices; Animal Welfare; Environmental Legislation; Economic Feasibility; Technological Advancements

Online: 5 December 2023 (04:38:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0104.v1

Barriers and Mythical Practices of Teenagers regarding Sexually Transmitted Infections Prevention in Rural Areas of Limpopo Province, South Africa

Jessica Uchechi Damian, Eustacia Hlungwane, Takalani Grace Tshitangano

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Barriers; Limpopo; Measures; Mythical; Practices; Prevention; Rural; STIs; Teenagers; Villages

Online: 5 December 2023 (04:38:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0051.v41

Duality Principles and Numerical Procedures for a Large Class of Non-convex Models in the Calculus of Variations

Fabio Botelho

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: duality theory; non-convex analysis; numerical method for a non-smooth model

Online: 5 December 2023 (04:38:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0212.v1

A Treatise on Reconnoitering the Suitability of Fuzzy MARCOS for Assessment of Conceptual Designs

Olayinka Mohammed Olabanji

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: Design concept selection; Fuzzy MARCOS; Design process; Multicriteria decision making; Briquetting machine

Online: 5 December 2023 (04:35:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0122.v1

Galactosylceramide Upregulates the Expression of the BCL2 Gene and Downregulates the Expression of TNFRSF1B and TNFRSF9 Genes, Acting as an Ani-apoptotic Molecule in Breast Cancer Cells

Jaroslaw Suchanski, Safoura Reza, Anna Urbaniak, Weronika Woldanska, Bartlomiej Kocbach, Maciej Ugorski

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: breast cancer; glycosphingolipids; apoptosis; chemoresistance

Online: 5 December 2023 (04:34:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0214.v1

Chromosome-Level Assemblies for the Pine Pitch Canker Pathogen Fusarium circinatum

Lieschen De Vos, Magriet A Van der Nest, Quentin C Santana, Stephanie Van Wyk, Kyle S. Leeuwendaal, Brenda D Wingfield, Emma T Steenkamp

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: dispensable chromosome; centromere; telomere; intrachromosomal translocation

Online: 5 December 2023 (04:33:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0055.v1

What Are the Most Common Types of Bias That Forensic Odontologists Face While Analyzing a Human Bitemark? A Scoping Review

Tayyaba Masood, Scheila Manica, Hemlata Pandey

Subject: Other, Biology And Life Sciences Keywords: ‘ bites’ ; bite marks; human bite marks; bias; cognitive bias; contextual bias

Online: 5 December 2023 (04:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1636.v2

Low-power Multi-bit Delta-Sigma Modulator based on Passive and Attenuationless Summation Scheme

Rongshan Wei, Lijie Huang, Gongxing Huang, Renping Wang, Cong Wei

Subject: Electrical And Electronic Engineering, Engineering Keywords: delta-sigma modulator; low power; passive summation; NS SAR; FIA

Online: 5 December 2023 (04:31:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0145.v1

Atomistic Modelling of Spinel Oxide Particle Shapes and Reshaping under OER Reaction Conditions

Luca Sementa, Alessandro Fortunelli, Öyküm Naz Avcı

Subject: Theoretical Chemistry, Chemistry And Materials Science Keywords: oxygen evolution reaction; Density Functional Theory; reaction mechanisms; spinel oxides

Online: 5 December 2023 (04:30:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1989.v1

Synthesis of Bis(cyclic Carbonates) from Epoxy Resin under Microwave Irradiation: The Structural Analysis and Evaluation of Thermal Properties

Edyta Hebda, Jan Ozimek, Kinga Szołdrowska, Krzysztof Pielichowski

Subject: Polymers And Plastics, Chemistry And Materials Science Keywords: cyclic carbonate; carbon dioxide; epoxy resin; CO2 utilization; thermal properties

Online: 5 December 2023 (04:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0210.v1

Spin Valve-Based Rhombus-Shaped Microobject Implementing Full Wheatstone Bridge

Mikhail Milyaev, Larisa Naumova, Anastasiya Germizina, Tatyana Chernyshova, Anastasia Pavlova, Tatiana Krinitsina, Vyacheslav Proglyado, Vladimir Ustinov

Subject: Applied Physics, Physical Sciences Keywords: spin valve; Wheatstone bridge; magnetic anisotropy; shape anisotropy; exchange bias field

Online: 5 December 2023 (04:29:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0220.v1

Cu(Ⅱ) Coordination Polymers Containing Mixed Ligands with Different Flexibility: Structural Diversity and Iodine Adsorption

Shu-Yu Lin, Yi-Lin Shen, Wei-Hao Chen, Manivannan Govindaraj, Jhy-Der Chen

Subject: Inorganic And Nuclear Chemistry, Chemistry And Materials Science Keywords: coordination polymer; crystal structure analysis; tricarboxylate; coordination mode

Online: 5 December 2023 (04:28:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1992.v1

Fungal-Bacterial Di-Kingdom Microbial Communities Associated with Chronic Pulmonary Disease

Israel Kiiza Njovu, Mary Akatuhumuriza, Brian Mumbere, Rose Magurusa, Musa Matovu, Jastus Kizito Mugenyi, Frank Ssedyabane, Pauline Petra Nalumaga, Kennedy Kassaza, Edwin Nuwagira, Joel Bazira, James Mukasa Kiguli, James Mwesigye, Jacob Stanely Iramiot, Benson Musinguzi, Jason King, Elizabeth Ballou, Lucas Ampaire, Herbert Itabangi

Subject: Pulmonary And Respiratory Medicine, Medicine And Pharmacology Keywords: Fungal; Bacterial; crosskingdom communiites; di-kingdom; pulmonary disease

Online: 5 December 2023 (04:28:14 CET)

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Fungal-bacterial co-colonization and co-infections are emerging among TB-suspected patients, yet the underlying mechanisms that enable and arise from their interactions are poorly understood. Understanding how environmental microbes such as fungi and bacteria co-evolve and develop traits to evade host immune responses and resist treatment is critical to controlling opportunistic co-infections. Our previous work has demonstrated that fungal-bacterial interactions can have dramatic impacts on fungal pathogenesis and drug resistance. Here, we, therefore, hypothesize that cross-kingdom synergistic interactions between environmental fungi and bacteria may influence both fungal and bacterial virulence, antimicrobial resistance patterns and aetiology. Through this, we aimed to establish the prevalence of fungal–bacterial microbial communities associated with chronic primary or opportunistic pulmonary infections. Concordantly, through surveilling 302 clinical samples from 151 patients, we established the prevalence of TB (0.7%) to be lower than that of fungi (1.3%) and non-TB bacterial (4.6%) mono-aetiologies Figure 2. However, our main observation was the unexpected taxonomic diversity with a striking twist of fungal-bacterial di-kingdom aetiological conformities. Interestingly, the majority of the patients presented with at least a di or mono-kingdom aetiological pairings. Importantly, fungi and non-TB bacteria formerly regarded as atypical opportunists are now frequently isolated as possible aetiology for chronic pulmonary infection. Hence, we revealed many di-kingdom aetiological pairings here but their significance remains a question of further examination. Among which Acremonium spp + K. pneumoniae (n=5), Acremonium spp +Streptococcus pneumoniae (n=4), Acremonium spp + C. albicans + K. pneumoniae (n=3) were among the most dominant aetiological pairings observed. Interestingly, Acremonium spp + K. pneumoniae pairings were also seen to be the most commonly associated with pulmonary TB both during and after treatment. Isolation from the same infection niche as seen here calls for further investigations into any interaction signatures that may exist between these organisms. Taken together, our data suggest that fungal-bacterial co-existence may influence their virulence attributes and antimicrobial resistance patterns, with relevance to patient outcomes. Therefore, our data reveals an array of fungal-bacterial pairings that may influence the prognosis of chronic pulmonary disease. Importantly, suggesting that the diversity of pulmonary infective fungi and bacteria, and their complex population structures may pose challenges to the analysis and interpretation of conventional data. Thus, there is a need to redirect our diagnostic approaches to encompass polymicrobial aetiology in order to enhance our suspicion index for better management of opportunistic fungal-bacterial co-infections.

Preprint ARTICLE | doi:10.20944/preprints202312.0217.v1

The Effect of Laser Surface Remelting on the Surface Properties of Copper

Hengzheng Li, Shuai Chen, Yang Chen, Zichen Tao, Conghu Liu

Subject: Mechanical Engineering, Engineering Keywords: Laser melting; Surface morphology; Microhardness; Wear resistance

Online: 5 December 2023 (04:27:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0225.v1

Research Progress on Doping and Coating of High-Nickel Cathode Materials for Lithium-Ion Batteries

Fusen Lv, Yun Ye, Shuhao Zhang, Yi Sun, Qiang Wang, Shuang Yuan

Subject: Materials Science And Technology, Chemistry And Materials Science Keywords: Lithium-ion batteries; High-nickel cathode materials; Bulk doping; Surface coating

Online: 5 December 2023 (04:26:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0205.v1

Integrating AI/ML in Cybersecurity: An Analysis of Open XDR Technology and its Application in Intrusion Detection and System Log Management

Dimitrios Lazaros Pissanidis, Konstantinos Demertzis

Subject: Security Systems, Computer Science And Mathematics Keywords: Artificial Intelligence; Machine Learning; Open Extended Detection and Response; Intrusion Detection Systems; Endpoint Detection and Response; Security Information and Event Management; Threat Detection and Response

Online: 5 December 2023 (04:25:34 CET)

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In today's digital landscape, cybersecurity has become a priority, with attacks becoming increasingly sophisticated. Traditional security approaches are no longer enough, requiring a more dynamic and advanced response. In this context, integrating Artificial Intelligence (AI) and Machine Learning (ML) appears key to addressing this growing threat. However, despite their high effectiveness, there is a developed problem: the integration of various data sources and technologies for comprehensive protection. This article presents an in-depth review of integrating Artificial Intelligence and Ma-chine Learning in cybersecurity, focusing particularly on Open Extended Detection and Response (Open XDR) technology. The methodology used is a detailed literature review, examining how various cybersecurity components interact and function. These components include Intrusion Detection Systems (IDS), which monitor networks for malicious activities; Endpoint Detection and Response (EDR), which focuses on detecting and investigating security incidents on endpoints; and Security Information and Event Management (SIEM), systems that provide real-time analysis of security alerts. The review also considers the role of Active Directory, a directory service for Windows domain networks, and the process of log forwarding, where log files are transmitted to a central server for analysis, in the context of AI and ML. The paper delves into the development of AI and ML, underscoring their roles in cybersecurity for advanced data processing, pattern recognition, and predicting threats. It explores both supervised (where the model is trained on labeled data) and unsupervised learning (where the model learns from unlabeled data) in ML, and how these techniques bolster cybersecurity measures. The article highlights the significance of Open XDR as a critical innovation that integrates data from multiple sources for comprehensive security analysis. Further, the review discusses how the integration of AI and ML into various cybersecurity tools, such as IDS, EDR, and SIEM, augments capabilities in threat detection and response. It addresses the challenges and opportunities that AI and ML present in the cybersecurity domain, focusing on ethical issues, data privacy concerns, and the necessity for ongoing professional development in this rapidly advancing field. The paper concludes by affirming the effectiveness of merging AI and ML with these cybersecurity tools within the Open XDR framework. This integration significantly enhances threat detection, response efficiency, and overall cybersecurity resilience. The aim is to provide a comprehensive understanding of the current state of cybersecurity technologies, their interaction with AI and ML, and insights into the field's future developments.

Preprint ARTICLE | doi:10.20944/preprints202312.0223.v1

Factors Affecting the Volatility of Bitcoin Prices

Renhong Wu, Md. Alamgir Hossain

Subject: Finance, Business, Economics And Management Keywords: Bitcoin price volatility; economic policy uncertainty; oil prices; NASDAQ index; gold prices

Online: 5 December 2023 (04:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0227.v1

Application of Probiotics in Aquaculture to Improve Growth and Health Performances of Nile tilapia

Tiruha Karssa, Maekel Sodeno, Kassaye Workagen, Natarajan Pavanasam, And Tasfaye Gada

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Aquaculture; gut micro flora; health; Nile tilapia; probiotics

Online: 4 December 2023 (17:31:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0224.v1

BBN Constraints and Indications for Beyond Standard Model Neutrino Physics

Daniela Kirilova, Mariana Panayotova, Emanuil Chizhov

Subject: Physical Sciences, Other Keywords: BSM physics; BBN constraints; neutrino oscillations; sterile neutrino; lepton asymmetry; drak radiation.

Online: 4 December 2023 (17:30:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0226.v1

Dynamic and Thermodynamic Contributions to Rainfall Changes in the Congo Basin: Evaluation of the Impact of an RCM's formulation

Alain T. Tamoffo, Alessandro Dosio, Torsten Weber, Derbetini A. Vondou

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Congo Basin; Precipitation Changes; Dynamic and Thermodynamic contributions; RCM’s Formulation; RCA4; RCP8.5

Online: 4 December 2023 (17:30:13 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202312.0228.v1

Natural Language Processing-Based Querying Heterogeneous Data Sources Using Integrated Ontology

Swathi S

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: NLP; AI; Heterogeneous databases; Ontology

Online: 4 December 2023 (16:20:05 CET)

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