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Preprint ARTICLE | doi:10.20944/preprints202306.0339.v1

The Language of Pain in the Hypermobile Ehlers-Danlos Syndrome: Metaphors as a Key to Understand the Experience of Pain and a Rehabilitation Tool

Filippo Camerota, Rachele Mariani, Giulia Cordiano, Michela Di Trani, Valentina Lodato, Alessandro Ferraris, Massimo Pasquini, Claudia Celletti

Subject: Clinical Medicine, Medicine And Pharmacology Keywords: Chronic Pain; Hypermobile Ehlers–Danlos syndrome; Linguistic content analysis; Metaphors; Pain; Symbolizing process

Online: 5 June 2023 (14:36:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0338.v1

Blood ACE2 protein level correlates with COVID-19 severity

Oksana Shevchuk, Anastasia Pak, Svitlana Palii, Yana Ivankiv, Kateryna Kozak, Mykhaylo Korda, Sandor G. Vari

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19; ACE2; severity; post-COVID-19 patients; comorbidity.

Online: 5 June 2023 (14:36:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0337.v1

Developing fermentation liquid of Bacillus amyloliquefaciens PMB04 to control bacterial leaf spot of sweet pepper

Fei Wang, Szu-Han Chao, Sabrina Diana Blanco, Chen-Hsuan Tsai, Yung-Yu Yang, Yi-Hsien Lin

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: agricultural management; antagonistic activity; fermentation formulation; copper-containing fungicides

Online: 5 June 2023 (14:31:43 CEST)

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Sweet pepper is an important vegetable in the world. Bacterial leaf spot caused by the pathogen Xanthomonas perforans, is a limiting factor that significantly reduces the quality and yield of sweet pepper To control this disease, the use of chemical fungicides is currently the main disease control method. Thus, we want to develop an alternative method by using antagonistic microorganisms. Under this demand, Bacillus amyloliquefaciens PMB04 has strong antagonistic effects against pathogens and can inhibit the occurrence of diseases. B. amyloliquefaciens PMB04 has the potential for the development of a disease control product. Primarily, PMB04 revealed to contain a strong inhibitory effect against all isolated X. perforans strains. In the inoculation assay, the severity of bacterial spot disease on sweet peppers was reduced by PMB04 bacterial suspensions. To increase the convenience of field application for future prospects, the development of PMB04 fermentation liquid was carried out with different ratios of brown sugar and yeast extract in a 30-liter fermentation tank subsequently. Results exhibited that the fermentation liquid of 3-1 formula obtained the highest bacterial population in a 30-liter fermentation tank. The fermentation liquid of 0.5-0.5 formula was the most stable formula under two different conditions in terms of consistent bacterial population and sporulation. In addition, the 200-fold dilution of 3-1 and 0.5-0.5 fermentation liquids revealed best control efficacy on bacterial leaf spot of sweet pepper. Additionally, the results of the 0.5-0.5 fermentation liquid (PMB4FL) with different dilution concentrations also showed that the 200- and 500-fold dilutions had the best control efficacy. To understand the effect of commonly used copper-containing fungicides on sweet peppers on the application of microbial agent PMB4FL, the effects of copper hydroxide and tribasic copper sulfate on the growth of X. perforans strains and B. amyloliquefaciens PMB04 were assayed. The results exhibited that the above two fungicides did not have any inhibitory effect on the growth of PMB04, but had a strong inhibitory effect on the X. perforans strain. In the follow-up control experiment, the treatment of copper hydroxide had no synergistic effect with PMB4FL to control bacterial leaf spot. We concluded that the use of PMB4FL fermentation liquid alone on the leaves can effectively control the occurrence of bacterial leaf spot in sweet pepper crops.

Preprint ARTICLE | doi:10.20944/preprints202306.0336.v1

Distributed Leadership: School Principal’s Practices Related With Teacher Professional Development for School Improvement

Marisol Galdames - Calderón

Subject: Education, Social Sciences Keywords: distributed leadership; school principal’s practices; teacher leadership; teacher profes-sional development

Online: 5 June 2023 (14:30:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0334.v1

Exploring Fuel Flexibility of Sputtered Thin Barrier Layers SOFC Cells: The Effect of Direct Ammonia Feeding on the Performances

Nunzia Coppola, Bertrand Morel, Giovanni Carapella, Dario Montinaro, Alice Galdi, Sami Ur Rehman, Pierpaolo Polverino, Cesare Pianese, Julie Mougin, Luigi Maritato

Subject: Energy And Fuel Technology, Engineering Keywords: sofc; ammonia; sputtered barrier layers; fuel flexibility

Online: 5 June 2023 (14:27:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0333.v1

Com@Rehab: An Interactive and Personalised Rehabilitation Activity Based on Virtual Reality

Carolina Silva, Cláudia Quaresma, Raquel Silva, Sara Carvalho, Rute Costa, Miguel Fernández, Andreia Pinto de Sousa, Ana Londral, Micaela Fonseca

Subject: Physical Therapy, Sports Therapy And Rehabilitation, Public Health And Healthcare Keywords: virtual reality (VR); COVID-19; motor rehabilitation; multidisciplinary; virtual reality activity; serious games; game design; health communication

Online: 5 June 2023 (14:26:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0335.v1

Prognostic Factors in Epithelioid Hemangioendothelioma: Analysis of a Nationwide Molecularly/Immunohistochemically Confirmed Cohort of 57 Cases

Tess Tomassen, Yvonne M H Versleijen-jonkers, Melissa H S Hillebrandt-roeffen, Patricia H J Van Cleef, Thijs Van Dalen, Marije E Weidema, Ingrid M E Desar, Uta Flucke, Joost M Van Gorp

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: Epithelioid hemangioendothelioma; Aggressive; Malignant; Prognosis; Risk stratification; Lymph node

Online: 5 June 2023 (14:26:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0332.v1

Did Cognitive–Attentional Syndrome Symptoms Predict Stress and Trauma-Related Symptoms in the Initial Phase of COVID-19 Pandemic? Results from a Two-Wave Study on a Sample of Polish Internet Users

Małgorzata Dragan, Piotr Grajewski

Subject: Psychology, Social Sciences Keywords: Cognitive–Attentional Syndrome; COVID-19 pandemic; stress and trauma related disorders; psychopathology; adjustment disorder

Online: 5 June 2023 (14:21:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0331.v1

Design of Airfield Rigid Pavement Condition Monitoring and Sensing System

Yong Luo, Mustafasanie Bin M Yussof

Subject: Civil Engineering, Engineering Keywords: strain sensor; monitoring; the pavement; perception system

Online: 5 June 2023 (13:58:32 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.0330.v1

Digital Design of Laser Sintered Metal Grids Supporting Orthodontic Treatment

Greta Roussanova Yordanova-Kostova, Milen Chalyovski, Gergana Gurgurova, Mirela Georgieva

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: Laser sintered metal grid; Digitally printed orthodontic grid; Interceptive treatment; Anchorage area

Online: 5 June 2023 (13:52:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0329.v1

Arrhythmias after COVID-19 Vaccination: Have We Left All Stones Unturned?

Nino Cocco, Gregor Leibundgut, Francesco Pelliccia, Valeria Cammalleri, Annunziata Nusca, Fabio Mangiacapra, Giulio Cocco, Valerio Fanale, Gian Paolo Ussia, Francesco Grigioni

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: SARS-CoV-2 vaccine side effect; vaccines and Heart rhythm disorders; Spike Protein and cardiac arrhythmias; ACE system and heart conduction; Angiotensin II and cardiac arrhythmias

Online: 5 June 2023 (13:40:58 CEST)

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-529391451442Citation: To be added by editorial staff during production. Academic Editor: Firstname Lastname Received: date Revised: date Accepted: date Published: date Copyright: © 2023 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).0Citation: To be added by editorial staff during production. Academic Editor: Firstname Lastname Received: date Revised: date Accepted: date Published: date Copyright: © 2023 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Abstract: SARS-CoV-2 vaccination offered the opportunity to get out of the pandemic and thereby worldwide health, social, and economic disasters. However, in addition to efficacy, safety is an important issue for any vaccine. The mRNA-based vaccine platform is considered to be safe but side effects are being reported more frequently as more and more people around the world become treated. Myo-pericarditis is the major, but not the only cardiovascular complication of this vaccine, hence it is important not to underestimate other side effects. We report a case series of patients affected by cardiac arrhythmias post mRNA vaccine from our clinical practice and the literature. Reviewing the official vigilance database emerged that heart rhythm disorders after Covid vaccination are not uncommon and deserve more clinical and scientific attention. Since Covid vaccine is the only vaccination to have been related to this side effect questions arose about whether these vaccines could affect heart conduction. Although the risk-benefit is clearly in favor of vaccination heart rhythm disorders are not a negligible issue and there are red flags in the literature about the risk of post-vaccination malignant arrhythmias in some predisposed patients. In light of these findings, we investigated the potential mechanism for the Covid vaccine to impact on cardiac electrophysiology and cause heart rhythm disorders.

Preprint ARTICLE | doi:10.20944/preprints202306.0328.v1

State-Owned Equity Participation and Corporations’ ESG Performance in China: The Mediating Role of Top Management Incentives

Caoyuan Yang, Ting Qian

Subject: Business And Management, Business, Economics And Management Keywords: ESG; State-owned equity; Top management incentives; Sustainability; Digital transformation

Online: 5 June 2023 (13:38:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0327.v1

Diel Rhythm of Feeding and Mating Behaviors of the Western Flower Thrips, Frankliniella occidentalis

Chulyoung Kim, Shamima Akter, Yonggyun Kim

Subject: Insect Science, Biology And Life Sciences Keywords: Circadian clock; Frankliniella occidentalis; Feeding; Mating; Behavior

Online: 5 June 2023 (13:35:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0326.v1

Estimation of Salt Intake in Normotensive and Hypertensive Dominican Adults: Assessment of 24 H Sodium and Potassium Urinary Excretion

Carlos Heriberto García-Lithgow, Madeline Durán-Cabral, Alexandra Winter-Matos, Kilsaris García-Estrella, Julen García-Durán, Estefanía Di-Sanzo, Nicole Martínez-De-La-Cruz, Julia Rodríguez-Abreu, Begoña Olmedilla-Alonso

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Dominicans; Hypertensive; Salt intake; Sodium and potassium excretion; Sodium-to-potassium ratio

Online: 5 June 2023 (13:29:58 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.0325.v1

Streptococcus intermedius Brain Abscess with Lung Abscess and Aortic Valve Endocarditis. A Case Report and Literature Review

Francesca Gavaruzzi, Pierangelo Chinello, Giuseppe Cucinotta, Gianluigi Oliva, Alessandro Capone, Guido Granata, Samir Al Moghazi, Emanuela Caraffa, Fabrizio Taglietti

Subject: Epidemiology And Infectious Diseases, Medicine And Pharmacology Keywords: Streptococcus intermedius; brain abscess; lung abscess; endocarditis

Online: 5 June 2023 (13:24:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0324.v1

Porous Gold Nanoparticles: Thermal Stability, Optical Response and Support-Free Synthesis

Laura Juhász, Zoltán Erdélyi, Csaba Cserháti

Subject: Nanotechnology, Chemistry And Materials Science Keywords: porous gold nanoparticles; plasmons, optical absorption,; dewetting, dealloying; support-free nanoparticles

Online: 5 June 2023 (13:20:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0323.v1

Utilizing Text Mining for Labeling Training Models from Futures Corpus in Generative AI

Hsien-Ming Chou, Tsai-Lun Cho

Subject: Information Systems, Computer Science And Mathematics Keywords: text mining; semantic analysis; labeling bull-bear words; futures corpus; generative AI

Online: 5 June 2023 (13:18:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0322.v1

Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis

Daniela Roxana Matasariu, Cristina-Elena Mandici, Alexandra Ursache, Alexandra Irma Gabriela Bausic, Iuliana Elena Bujor, Alexandra Elena Cristofor, Elvira Bratila, Ludmila Lozneanu

Subject: Obstetrics And Gynaecology, Medicine And Pharmacology Keywords: phosphohistone H3; vitamin D; vitamin D receptor; progesterone; endometriosis; immunohistochemistry

Online: 5 June 2023 (13:14:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0321.v1

Right Ventricle Assessment before Tricuspid Valve Interventions

Angelica Cersosimo, Mara Gavazzoni, Riccardo Maria Inciardi, Marianna Adamo, Gianmarco Arabia, Marco Metra, Riccardo Raddino, Enrico Vizzardi

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: right ventricular; tricuspid valve; tricuspid regurgitation; right ventricular remodeling

Online: 5 June 2023 (13:10:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0320.v1

Do the Blueberries We Purchase in Different Outlets Have Acceptable Quality Attributes?

M. Teresa Sanchez-Ballesta, Carmen Marti-Anders, María Dolores Álvarez, M. Isabel Escribano, Carmen Merodio, Irene Romero

Subject: Food Science And Technology, Biology And Life Sciences Keywords: Blueberries; quality; firmness; fungal infection; anthocyanin content; phenolic content; antioxidant capacity

Online: 5 June 2023 (13:04:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0319.v1

Study on the Prevalence of Pneumocystis jirovecii as a Causative Agent of Lung Pathology in People with Different Immune Status

Rumen Harizanov, Nina Tsvetkova, Aleksandra Ivanova, Raina Enikova, Mihaela Videnova, Iskra Rainova, Eleonora Kaneva, Iskren Kaftandjiev, Dimitar Strashimirov, Nina Yancheva-Petrova, Ivan Simeonovski, Viktoria Levterova, Nikolai Yanev

Subject: Primary Health Care, Public Health And Healthcare Keywords: Pneumocystis pneumonia; immune status; real-time PCR; staining methods

Online: 5 June 2023 (12:55:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0318.v1

Sulforaphane Reduces Chronic Inflammatory Immune Response of Human Dendritic Cells

Laura Fernández-Prades, Mariano Brasal-Prieto, Gonzalo Alba, Victoria Martín, Sergio Montserrat-de la Paz, Marta Cejudo-Guillen, Consuelo Santa-Maria, Hala Dakhaoui, Beatriz Granados, Francisco Sobrino, Francisca Palomares, Soledad Lopez-Enriquez

Subject: Dietetics And Nutrition, Medicine And Pharmacology Keywords: nutraceutic; dendritic cells; T lymphocytes; anti-inflammatory response; autophagy; apoptosis

Online: 5 June 2023 (12:50:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0317.v1

Parental Burnout in the Context of Special Needs, Adoption, and Single Parenthood

Isabelle Roskam, Moïra Mikolajczak

Subject: Social Sciences, Psychology Keywords: exhaustion; disability; illness; disorder; adopted child; adoptive parent; single mom; single dad

Online: 5 June 2023 (12:07:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0316.v1

Study of Complaints and Grievances regarding the Treatment and Information Provided to Users of Primary Care in the Sanitary Area of Santiago and Barbanza from 2020–2022. A Cross-Sectional Study in Spain

Maria Fernanda Velazquez-Lopez, Maria Garcia-Perez, Montserrat Souto-Pereira, Juan M. Vazquez-Lago

Subject: Public Health And Healthcare, Primary Health Care Keywords: primary care; grievances; complaints; satisfaction

Online: 5 June 2023 (12:04:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0315.v1

Quantifying the Economic and Financial Viability of NB-IoT and LoRaWAN Technologies: A Comprehensive Life Cycle Cost Analysis Using Pragmatic Computational Tools

Bernhard Koelmel, Max Borsch, Rebecca Bulander, Lukas Waidelich, Tanja Brugger, Ansgar Kuehn, Matthias Weyer, Luc Schmerber, Michael Krutwig

Subject: Computer Science And Mathematics, Other Keywords: Financial Viability; Life Cycle Cost Analysis; LPWAN; Pragmatic Computational Tools; Design Science Research, Data-driven decision making

Online: 5 June 2023 (12:00:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0313.v1

Epidermal growth factor receptor T790M Mutation Testing in Non-small Cell Lung Cancer: An International Collaborative Study to Assess Molecular EGFR T790M Testing in Liquid Biopsy

Martin Filipits, Verena Kainz, Viktor Sebek, Herwig Zach

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Liquid biopsy; EGFR; NSCLC; T790M mutation; NGS; PCR

Online: 5 June 2023 (11:06:11 CEST)

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Background: The detection of the EGFR T790M (T790M) mutation in non-small cell lung cancer (NSCLC) patients who progressed under treatment with first- or second-generation EGFR-tyrosine kinase inhibitors (TKIs) is important to offer a subsequent therapy with a third-generation EGFR-TKI. Liquid biopsy is a powerful tool to determine the T790M mutation status. Several liquid biopsy platforms with varying degrees of accuracy are available to test for T790M mutations and sensitivities may differ among these methods. Methods: As no standard exists for the testing of T790M mutation in liquid biopsy, we performed a collaborative study to describe and compare the sensitivity of different in-house liquid biopsy platforms for the detection of the T790M mutation, EGFR exon 19 deletion (del19) and EGFR L858R mutation (L858R) across multiple participating laboratories in seven Central and Eastern European countries. Results: Of the 25 invited laboratories across Central and Eastern Europe, 21 centers participated and received 10 plasma samples spiked with cell-line DNA containing the T790M, del19, or L858R mutation in different concentrations. In-house PCR-based and NGS-based methods were used accordingly, and results reported as in routine clinical practice. Two laboratories, which used the AmoyDx® EGFR 29 Mutations Detection Kit (AmoyDx) with Cobas® cfDNA Sample Preparation Kit and QX200 Droplet Digital PCR (ddPCR) with the QIAamp Circulating Nucleic Acid Kit identified all ten samples correctly. Cobas® EGFR Mutation Test v2 (Cobas), the NGS methods, and the IdyllaTM detection method used in this study performed within the known sensitivity range of each detection method. Conclusions: If a negative result was obtained from methods with lower sensitivity (e.g. Cobas), repeated liquid biopsy testing and/or tissue biopsy analysis should be performed whenever possible, with the aim of identifying T790M-positive patients to allow them to receive the optimal second-line treatment with a third-generation EGFR TKI.

Preprint ARTICLE | doi:10.20944/preprints202304.1217.v2

Assessment of Thermal and Mechanical Properties of Cement-Based Materials—Part 2: Perlite Concrete

Dorina Nicolina Isopescu, Alexandra Cojocaru, Ioana-Roxana Baciu, Sebastian George Maxineasa, Sergiu George Petre

Subject: Engineering, Architecture, Building And Construction Keywords: sustainability; cement-based materials; concrete; perlite; physico-mechanical properties; energy performance

Online: 5 June 2023 (10:57:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0311.v1

Patient Attitudes Regarding Audio-Only Telemedicine in Rural Minnesota

Samuel Nelson, Nicholas Battis, Ryan Harden

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Rural; Telemedicine; Telehealth; Patient-Centered; Attitudes; Perceptions; Audio-only

Online: 5 June 2023 (10:51:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0310.v1

Aerobic Exercise Training Improves Calcium Handling and Cardiac Function in Rats with Heart Failure Resulting from Aortic Stenosis

Vitor Loureiro Da Silva, Gustavo Augusto Ferreira Mota, Sérgio Luiz Borges De Souza, Dijon Henrique Salomé De Campos, Alexandre Barroso Melo, Danielle Fernandes Vileigas, Priscila Murucci Coelho, Paula Grippa Sant’Ana, Carlos Padovani, Ana Paula Lima-Leopoldo, Silméia Garcia Zanati Bazan, Andre Soares Leopoldo, Antonio Carlos Cicogna

Subject: Biology And Life Sciences, Life Sciences Keywords: exercise training; aortic stenosis; heart failure; isolated papillary muscle; isolated cardiomyocyte; calcium handling.

Online: 5 June 2023 (10:47:28 CEST)

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Aerobic exercise training (AET) has been used in the management of heart disease. AET may, totally or partially, restore the activity and/or expression of proteins that regulate calcium (Ca2+) handling, optimize intracellular Ca2+ flow, and attenuate cardiac functional impairment in failing hearts. However, the literature presents conflicting data regarding the effects of AET on Ca2+ transit and cardiac function in rats with heart failure resulting from aortic stenosis. The objective of this study was to evaluate the effects of AET on calcium handling and cardiac function in rats with heart failure due to aortic stenosis. Wistar rats were distributed into two groups: control (Sham; n= 61) and aortic stenosis (AoS; n= 44). After 18 weeks, the groups were redistributed into: non-exposed to exercise training (Sham, n = 28 and AoS, n = 22) and trained (Sham-ET, n = 33 and AoS-ET, n = 22) for 10 weeks. Treadmill exercise training was performed with a velocity equivalent to the lactate threshold. Echocardiogram, isolated papillary muscle, and isolated cardiomyocyte analyzed cardiac function. During isolated papillary muscle assay and isolated cardimyocyte was evaluated Ca2+. The expression of regulatory proteins of diastolic Ca2+ was analyzed via Western Blot. AET attenuated the diastolic dysfunction and benefited the systolic function. AoS-ET animals presented better response to post-rest contraction, and SERCA2a and L-type Ca2+ channels blocked than the AoS. Furthermore, AET was able to improve aspects of the mechanical function and the responsiveness of the myofilaments to the Ca2+ of the AoS-ET animals. AoS animals presented alteration in the protein expression of the SERCA2a and NCX, and AET restored SERCA2a and NCX levels near normal values. Therefore, AET increased SERCA2a activity, improved the cellular Ca2+ influx mechanism, and increased myofilament responsiveness to Ca2+, attenuating cardiac dysfunction at cellular, tissue, and chamber levels in animals with aortic stenosis and heart failure.

Preprint ARTICLE | doi:10.20944/preprints202306.0309.v1

A Machine Learning Python-based Search Engine Optimization Audit Software

Konstantinos I. Roumeliotis, Nikolaos D. Tselikas

Subject: Computer Science And Mathematics, Software Keywords: search engine optimization; seo techniques; python seo tool; machine learning seo

Online: 5 June 2023 (10:38:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0308.v1

Antibacterial Thermo-Sensitive Silver Hydrogel Nanocomposite Improves Wound Healing

Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Kilani, Frank Ko, Aziz Ghahary, Dirk Lange

Subject: Chemistry And Materials Science, Biomaterials Keywords: Wound healing; Antibacterial; Hydrogel; Meshfill; Silver nanocomposite

Online: 5 June 2023 (10:34:40 CEST)

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Introduction: Among the many factors that may limit effective wound healing in patients with chronic ulcers, bacterial infection and poor cell recruitment are primary causes that contribute to prolonged healing. Thus, a novel strategy that aims to prevent bacterial infection within the wound, while at the same time providing structural scaffolding that promotes endogenous tissue repair, would be of great interest. Here, we developed a thermo-sensitive silver nanoparticle hydrogel composite as an antibacterial nutritional scaffold for the wound that contains all nutrients required for cell growth while preventing bacterial infection with the ability to fill up all the cavities and void areas in wounds regardless of their geometry. Methods: Silver nanoparticles (AgNPs) were synthesized by chemical reduction. After characterization, silver hydrogel nanocomposite was developed by reconstitution of collagen-based hydrogel powder in a nanoparticle suspension of varying AgNPs concentrations (200, 400, and 600 ppm). The antibacterial activity of the formulations was examined in vitro and in vivo in subcutaneous implant infected model. The wound healing efficacy of the hydrogel nanocomposite was also evaluated using a splinted wound model in rats through comparison of clinical wound measurements and histological assessments. Cytocompatibility assay and biochemical analysis of blood at the end of in vivo wound healing study were performed to evaluate the safety of formulations. Results: The synthesized nanoparticles were spherical and stable. While hydrogel alone did not show any bacterial reduction in vitro, the inhibition of bacterial growth was significant in all silver hydrogel nanocomposites compared to controls (p <0.05) and was dose-dependent, with maximum reduction observed in the 600 ppm group (4.56±0.26 LOG CFU/mL, P<0.001). All concentrations of AgNPs hydrogel composites showed significant antibacterial activity in vivo as well (P<0.0001). Treatment of splinted wounds with AgNPs hydrogel composite resulted in faster wound closure and accelerated wound re-epithelialization. The formulations were non-cytotoxic and did not differ significantly in hematological and biochemical factors from the control group in in vivo study. Conclusions: By presenting promising antibacterial and wound healing activity, silver hydrogel nanocomposite offers a safe therapeutic option that can be used as a functional scaffold for an acceleration of wound healing.

Preprint ARTICLE | doi:10.20944/preprints202306.0307.v1

Near-Field Coupling Effect Analysis of SMD Inductor Using 3D-EM model

GyeongRyun Choi, HyongJoo Kim, Yonggi Hong, Joosung Hwang, Euihyuk Kim, Wansoo Nah

Subject: Engineering, Electrical And Electronic Engineering Keywords: SMD inductor; loss tangent; effective permeability; Near-field coupling

Online: 5 June 2023 (10:30:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0306.v1

Effects of Autologous Microfragmented Adipose Tissue on Bone Healing: A Blinded, Prospective, Randomised Canine Clinical Trial

Luca Pennasilico, Caterina Di Bella, Sara Sassaroli, Alberto Salvaggio, Francesco Roggiolani, Angela Palumbo Piccionello

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: microfragmented adipose tissue; regenerative medicine; bone healing, osteotomy, cranial cruciate ligament

Online: 5 June 2023 (10:22:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0305.v1

Preparation, Characterization, and In Vitro Evaluation of the Biological Activity of Several Metal-Based Complexes with Two Widely Used Fluoroquinolones Antibiotics: Lomefloxacin and Pefloxacin Drugs

Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmed M. Naglah, Mashooq A. Bhat, Razan Eskandrani, Fatimah A. Alotaibi, Moamen S. Refat, Abdel Majid A. Adam

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Fluoroquinolones; Lomefloxacin; Pefloxacin Metal-based complex; Spectroscopies; Biological activities

Online: 5 June 2023 (10:22:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0304.v1

Community-Based Agro-Ecotourism Sustainability in West Java, Indonesia

Endah Djuwendah, Tuti Karyani, Eliana Wulandari, Pradono Pradono

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: agro-ecotourism; sustainability; community; West Java; Indonesia

Online: 5 June 2023 (10:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0303.v1

A Methodology Based on Lidar, Time-Of-Flight Camera and Odometry for a Real-Time 3D Model Generation

Carlos M Mesa-Cantillo, Itziar Alonso-González, David Sánchez-Rodríguez, Miguel A Quintana-Suárez, Kilian D García-Mederos

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: time-of-flight; LiDAR; indoor mapping; ROS; SLAM

Online: 5 June 2023 (10:17:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0302.v1

Formation of the Hydroxyapatite-based Hybrid Materials in Presence of Platelet-Poor Plasma Additive

Ilya Evgen'evich Glazov, Valentina Konstantinovna Krut’ko, Tatiana Viktorovna Safronova, Nikita Aleksandrovich Sazhnev, Natalia Rustemovna Kil'deeva, Roman Alekseevich Vlasov, Olga Nikolaevna Musskaya, Anatoly Iosifovich Kulak

Subject: Chemistry And Materials Science, Biomaterials Keywords: hybrid material; hydroxyapatite formation; amorphous calcium phosphate; platelet-poor plasma; phase composition

Online: 5 June 2023 (10:14:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0301.v1

Remote Monitoring of Canine Patients Treated for Pruritus during the COVID Pandemic in Florida Using a 3-D Accelerometer

Michael Canfield, Robert P. Lavan, Timberly Canfield, Gal Gingold, Jennifer Thomas, Bridgette Sampeck, Tonya Springer, Rob Armstrong

Subject: Medicine And Pharmacology, Dermatology Keywords: pruritus; 3D-accellerometer; monitoring; allergic skin disease; canine atopic dermatitis

Online: 5 June 2023 (10:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0300.v1

Accuracy Improved Classification and Regression Tree (CART) Model: Diabetes Prediction Using Minority Over-Sampling and Particle Swarm Optimization Techniques

Yohanes Leonardus Sukestiyarno, Mahrus Zufar Rofif

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: CART algorithm; Accuracy; Synthetic Minority Over-sampling Technique; Particle Swarm Optimization

Online: 5 June 2023 (10:10:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0299.v1

Microbial Dynamics in Anaerobic Digestion: A Review of Operational and Environmental Factors Affecting Microbiome Composition and Function

Eleni Kostopoulou, Afroditi G. Chioti, Vassiliki Tsioni, Themistoklis Sfetsas

Subject: Environmental And Earth Sciences, Other Keywords: anaerobic digestion; microbial structure; microbial interactions; operating parameters; digestion efficiency

Online: 5 June 2023 (10:09:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0298.v1

Sustainability Assessments of Peri-Urban Areas: An Evaluation Model for the Territorialization of the Sustainable Development Goals

Pasquale De Toro, Enrico Formato, Nicola Fierro

Subject: Environmental And Earth Sciences, Environmental Science Keywords: sustainability assessment; Sustainable Development Goals; Agenda 2030; peri-urban fringe; multidimensional indicators; evaluation tools; sustainable development; spatial decision support system

Online: 5 June 2023 (10:08:30 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202306.0297.v1

Dynamically Tunable Deflection of Radiation Based on Epsilon-Near-Zero Material

Lin Cheng, Kun Huang, Yu Wang, Fan Wu

Subject: Physical Sciences, Theoretical Physics Keywords: Tunable deflection; epsilon-near-zero; metamaterial.

Online: 5 June 2023 (10:07:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0271.v1

The Potential of Replacing Concrete with Sand and Recycled Polycarbonate Composites: Compressive Strength Testing

Morgan C. Woods, Apoorv Kulkarni, And Joshua M. Pearce

Subject: Engineering, Mechanical Engineering Keywords: waste plastic composites; poly carbonate; polycarbonate composite; sand; plastic and sand composites; plastic sand bricks; concrete; construction; compressive strength; mechanical properties

Online: 5 June 2023 (10:00:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0296.v1

Dynamic Output Feedback and Neural Network Control of a Non-Holonomic Mobile Robot

Manuel Cardona, Fernando E. Serrano

Subject: Computer Science And Mathematics, Robotics Keywords: Mobile Robot; Non-holonomy; Driftless Control

Online: 5 June 2023 (10:00:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0295.v1

Multi-criterion Sampling Matting Algorithm via Gaussian Process

Yuan Yang, Hong shan Gou, Mian Tan, Fu Jian Feng, Yi hui Liang, Yi Xiang, Lin Wang, Han Huang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: computing resources; Gaussian process fitting model; multi-criterion sampling strategy; high-quality pixel pairs; alpha matte

Online: 5 June 2023 (10:00:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0276.v1

Strain Modulation of Electronic Properties in Monolayer SnP2S6 and GeP2S6

Junlei Zhou, Yuzhou Gu, Yue-E Xie, Fen Qiao, Jiaren Yuan, JingJing He, Sake Wang, Yangsheng Li, Yangbo Zhou

Subject: Physical Sciences, Condensed Matter Physics Keywords: Monolayer semiconductor; Band gap; Electronic structure; Biaxial strain; DFT calculations

Online: 5 June 2023 (09:58:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0294.v1

Assessment of State of Art in the Performance, Their Utilization Level of Automated Vehicles

Teshome Kumsa Kurse, Girma Gebresenbet, Geleta Fikadu Daba

Subject: Engineering, Automotive Engineering Keywords: automated vehicle; performance assessment; sensor; sound navigator; utilization level

Online: 5 June 2023 (09:57:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0596.v2

Feasibility of Proton Dosimetry Overriding Planning CT with Daily CBCT Elaborated through Generative Artificial Intelligence Tools

Matteo Rossi, Gabriele Belotti, Luca Mainardi, Guido Baroni, Pietro Cerveri

Subject: Engineering, Bioengineering Keywords: Deep Learning; image-to-image translation; dosimetry; cycleGAN; CBCT; CT; limited FOV; artifact correction; Hounsfield unit recovery

Online: 5 June 2023 (09:53:36 CEST)

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Radiotherapy commonly utilizes CBCT for patient positioning and treatment monitoring. CBCT is deemed to be secure for patients, making it suitable for the delivery of fractional doses. However, limitations such as a narrow field of view, beam hardening, scattered radiation artifacts, and variability in pixel intensity hinder the direct use of raw CBCT for dose recalculation during treatment. To address this issue, reliable correction techniques are necessary to remove artifacts and remap pixel intensity into HU values. This study proposes a deep-learning framework for calibrating CBCT images acquired with narrow FOV systems and demonstrates its potential use in proton treatment planning updates. Cycle-consistent GAN processes raw CBCT to reduce scatter and remap HU. Monte Carlo simulation is used to generate CBCT scans, enabling the possibility to focus solely on the algorithm’s ability to reduce artifacts and cupping effects without considering intra-patient longitudinal variability and producing a fair comparison between planning CT and calibrated CBCT dosimetry. To showcase the viability of the approach using real-world data, experiments were also conducted using real CBCT. Tests were performed on a publicly available dataset of 40 patients who received ablative radiation therapy for pancreatic cancer. The simulated CBCT calibration led to a difference in proton dosimetry of less than 2%, compared to the planning CT. The potential toxicity effect on the organs at risk decreased from about 50% (uncalibrated) up the 2% (calibrated). The gamma pass rate at 3%/2mm produced an improvement of about 37% in replicating the prescribed dose before and after calibration (53.78% vs 90.26%). Real data also confirmed this with slightly inferior performances for the same criteria (65.36% vs 87.20%). These results may confirm that generative artificial intelligence brings the use of narrow FOV CBCT scans incrementally closer to clinical translation in proton therapy planning updates.

Preprint ARTICLE | doi:10.20944/preprints202306.0293.v1

Biologically Relevant Murine Models of Chronic Pseudomonas aeruginosa Respiratory Infection

Aoife M Rogers, Jaime Lindsay, Avril Monahan, Alice V Dubois, Aduragbemi A Faniyi, Barry J Plant, Marcus A. Mall, Miquel B Ekkelenkamp, J Stuart Elborn, Rebecca J Ingram

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Pseudomonas aeruginosa; chronic infection; respiratory; murine model; in vivo; S. aureus

Online: 5 June 2023 (09:50:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0292.v1

Stochastic Comparisons of Lifetimes of used Standby Systems

Mohamed Kayid, Mashael A. Alshehri

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: likelihood ratio order; usual stochastic order; cold-standby system; log-concave; logconvex; lifetime

Online: 5 June 2023 (09:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0291.v1

Measurement of Abdominal Fat by Nutritional Ultrasound as a Risk Factor for Non-alcoholic Hepatic Steatosis (Nash) in Obese Children

Sandra Maeso Mendez, Ainhoa Sarasua-Miranda, Zuriñe Garcia Casares, Ariane Calvo Saez, Erika Santos Corraliza, Ainara Gamarra CAbrerizo, Ignacio Diez Lopez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: obesity NASH

Online: 5 June 2023 (09:38:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0290.v1

Translational and Rotational Postural Aberrations are related to Pulmonary Functions and Skill Related Physical Fitness Components in Collegiate Athletes

May Tamim, Ibrahim Moustafa Moustafa, Gopala Krishna Alaparthi, Paul A. Oakley, Deed E Harrison

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Posture; Athletic performance; Athletes; Cardiopulmonary performance

Online: 5 June 2023 (09:37:32 CEST)

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This study assessed the relationship between body posture displacements and cardiopulmonary function test (CPET) and skill related physical fitness tests. One hundred male (60%) and female collegiate athletes (22.2 ± 4yrs) with a normal body mass index (BMI up to 24.9) were assessed via the PostureScreen Mobile app to quantify postural displacements as head, thorax and pelvis rotations and translations. CPET and physical performance tests including the agility T-test, the vertical jump test, the stork static balance test (SSBT) and the dynamic Y-balance test (YBT) were performed. Spearman correlation (r) and p-values are reported. Postural parameters were found to have moderate-to-high associations with CPET and the agility test, moderate correlations with the vertical jump test and the SSBT (head and pelvic postures only), and weak correlations with the YBT. As postural parameters were more asymmetric, both CPET and performance skills scores were worse. For examples: 1) a medium positive correlation was found between cranio-vertebral angle (CVA) and vertical jump test (r = 0.54; p-value < 0.001) and SSBT (r = 0.57; p-value < 0.001), while a strong negative correlation was found between CVA and agility test (r = -0.86; p-value < 0.001). 2) A strong positive correlation was found between CVA and oxygen uptake efficiency slope, load watts VO2 at VT, VO2 / kg, load watts at respiratory compensation point (RCP), (r = 0.65 and r = 0.71; p < 0.001). Conversely, a significant negative correlation was found between CVA and VE / VO2 at VT (r = -0.61; p < 0.001). Postural rotations and translations of the head, thorax and pelvis were statistically correlated with physical performance skills and CPET in young collegiate athletes. There were moderate-to-high associations with cardiopulmonary functions and agility tests, moderate correlations with the vertical jump test, and weak correlations with the YBT. Postural alignment may be important for optimal physical performance and optimal cardiopulmonary function. Further research is necessary to elucidate reasons for these correlations as found in our sample of young and healthy athletes.

Preprint ARTICLE | doi:10.20944/preprints202306.0289.v1

Item-Oriented Personalized LDP for Discrete Distribution Estimation

Xin Li, Hong Zhu, Zhiqiang Zhang, Meiyi Xie

Subject: Computer Science And Mathematics, Other Keywords: Discrete distribution estimation, Local differential privacy, Item-oriented personalization, Randomized response

Online: 5 June 2023 (09:36:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1218.v2

Overlapping of Lévai’s and Milson’s E-Tangent-Polynomial Potentials along Symmetric Curves

Gregory Natanson

Subject: Physical Sciences, Mathematical Physics Keywords: rational Sturm-Liouville equation; Liouville transformation; complex Jacobi polynomials, classical Jacobi polynomials, Romanovski-Routh polynomials, Masjed-Jamei polynomials; quasi-rational solutions, almost-everywhere holomorphic solutions

Online: 5 June 2023 (09:30:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0288.v1

Identifying the Common Cell-Free DNA Biomarkers across Seven Major Cancer Types

Mingyu Luo, Yining Liu, Min Zhao

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Early cancer diagnosis; cell free DNA; biomarker; integrative biology; pan cancer

Online: 5 June 2023 (09:20:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0287.v1

FANet: Flexibility and Adaptivity Net for 3D Point Cloud Detection

Jian Ye, Fushan Zuo, Yuqing Qian

Subject: Engineering, Automotive Engineering Keywords: autonomous driving; object detection; Position Adaptive Convolution; FANet

Online: 5 June 2023 (09:15:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0286.v1

People Living with HIV (PLWH) Controllers Induce High Production of IFN-γ to Gag Epitope

Bosco Christiano Maciel Da Silva, Lais Teodoro Da Silva, Gustavo Ferminie Hildebrando, Paula Ordonhez Rigato, Luis Fernando de Macedo Brigido, Marcello Mihailenko Chaves Magri, Mariana Amélia Monteiro, Tatiane Assone, Alberto José da Silva Duarte, Jorge Casseb

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Human Immunodeficiency Virus (HIV); Long-Term Non-Progressor (LTNP), Elite Controllers (EC); Viremic Controllers (VC); IFN-γ T cell responses; Human Leukocyte Antigens (HLA)

Online: 5 June 2023 (09:10:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0285.v1

Intelligent Identification and Prediction Mineral Resources Deposit Based on Deep Learning

Le Gao, Kun Wang, Xin Zhang, Chen Wang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial Intelligence; Sustainable development; Deep Learning; Mineral Deposit Prediction; Multi-scale Features; Attention Mechanism

Online: 5 June 2023 (09:05:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0284.v1

Automatic River Planform Recognition Tested on Chilean Rivers

Andrea Gianni Cristoforo Nardini, Francisca Salas, Zoila Carrasco, Noelia Valenzuela, Renzo Rojas, José Vargas-Baecheler, Santiago Paul Yepez

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: River Planform; River Reaches; Automatic Identification; Geomorphics Elements and Units; Biobío Basin

Online: 5 June 2023 (09:02:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0283.v1

A Deep Neural Network Regression of the Cahn–Hilliard Single-Particle Thermal Model for LiFePO₄ Batteries

Roger Painter, Ranganathan Parthasarathy, Lin Li, Irucka Embry, Lonnie Sharpe, S. Keith Hargrove

Subject: Engineering, Chemical Engineering Keywords: lithium-ion batteries; LIB; LiFePO4; electric vehicles; Cahn–Hilliard; principal component analysis; neural networks

Online: 5 June 2023 (09:01:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2091.v2

Culture, Mindset and Functionality in Regional Organisations – A Study on ASEAN and the European Union

Tuomo Rautakivi, Maurice Yolles

Subject: Social Sciences, Political Science Keywords: Regional organisations; Gemeinschaft-Gesellschaft; Collectivism-Individualism; Cultural Agency Theory; metacybernetics; political development; social psychology; Mindset Agency Theory; normative personality; EU; ASEAN

Online: 5 June 2023 (09:00:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0282.v1

Marine Calcareous Biological Ooze Thermoluminescence and its Application for Paleoclimate Change since Middle Pleistocene

Zhang Ping, Liu Haisheng, Hou Shengli, Wang Nanping, Fang Nianqiao

Subject: Environmental And Earth Sciences, Oceanography Keywords: Indian Ocean; North Atlantic; Thermoluminescence; calcareous biological ooze; paleoclimate

Online: 5 June 2023 (08:48:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0281.v1

Multi-Scale YOLOv5-AFAM Based Infrared Dim Small Target Detection

Yuexing Wang, Liu Zhao, Yixiang Ma, Yuanyuan Shi, Jinwen Tian

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Infrared dim small targets; Object detection; Adaptive Fusion Attention Module; ISVD

Online: 5 June 2023 (08:47:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0280.v1

Leadership towards Sustainability: A Review of Sustainable, Sustainability and Environmental Leadership

Jane Boeske

Subject: Business, Economics And Management, Business And Management Keywords: sustainable leadership; sustainability leadership; environmental leadership; sustainability; leadership

Online: 5 June 2023 (08:46:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0279.v1

An Outbreak of Newcastle Disease Virus in the Moscow Region in the Summer of 2022

Artyom Rtishchev, Anastasia Treshchalina, Elena Shustova, Elizaveta Boravleva, Alexandra Gambaryan

Subject: Biology And Life Sciences, Virology Keywords: NDV; paramyxovirus; outbreak; pathogenicity

Online: 5 June 2023 (08:43:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0278.v1

Mechanism of Social Stress-Related Erectile Dysfunction in Mice: Impaired Parasympathetic Neurotransmission and Ketamine

Shu-Yu Wu, Tze-Chen Chao, Chun-Kai Hsu, His-Hsien Chang, Stephen Shei-Dei Yang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: erectile dysfunction; social stress; ketamine; sexual dysfunction

Online: 5 June 2023 (08:41:13 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202306.0277.v1

Ocean Wave Energy Converter (WEC) with IoT Applications

Md Shohel Amin

Subject: Engineering, Electrical And Electronic Engineering Keywords: Wave Energy Converter (WEC); IoT-based sensors; Wireless devices

Online: 5 June 2023 (08:39:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0274.v1

Participative Policy Design to Manage Droughts and Floods in an Arid Region under Climate Change Uncertainty: The Case of Baja California Sur, Mexico

Antonina Ivanova-Boncheva, Miguel Angel Imáz- Lamadrid, Maria Z-Flores, Mara Y. Cortes-Martinez

Subject: Social Sciences, Geography, Planning And Development Keywords: participative policy; drought; floods; risk-management; climate change; resilience; Mexico

Online: 5 June 2023 (08:37:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0275.v1

Understanding the Impact of COVID-19 on Angioplasty Service and Outcome of Patients Treated for Critical Limb Ischaemia: A Single-Centre Retrospective Cohort Study

Alexander D. Rodway, Jenny Harris, Lydia Hanna, Charlotte Allan, Felipe Pazos-Casal, Ciara Giltinan, Ali Dehghan-Nayeri, Andre Santos, Martin B. Whyte, Nikolaos Ntagiantas, Ivan Walton, Richard Brown, Simon S. Skene, Ajay Pankhania, Benjamin C.T. Field, Gary D. Maytham, Christian Heiss

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: day-case angioplasty; critical limb ischaemia; peripheral artery disease

Online: 5 June 2023 (08:37:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0273.v1

Does Precision Technologies Adoption Contribute to the Economic and Agri-Environmental Sustainability of Mediterranean Wheat Production? An Italian Case Study

Adele Finco, Deborah Bentivoglio, Matteo Belletti, Giulia Chiaraluce, Marco Fiorentini, Luigi Ledda, Roberto Orsini

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: precision agriculture; durum wheat; Italy; case study; economic impact; agro-environmental impact; sustainability; nitrogen efficiency; profitability

Online: 5 June 2023 (08:32:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0272.v1

Investigating the Potential Adoption of Product-Service Systems in the Luggage Industry To Promote Sustainability

Donald Wilson, Eleni Iacovidou

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Product-Service System (PSS); Circular economy; Luggage; sustainable travel; sustainable con-sumption; sustainable production

Online: 5 June 2023 (08:30:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0270.v1

The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Mycoplasma pneumoniae Infection

Natalie Iannuzo, Alane Blythe C. Dy, Stefano Guerra, Paul R. Langlais, Julie G. Ledford

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Mycoplasma pneumoniae; CC16; CCSP; CC10; mass spectrometry; remodeling

Online: 5 June 2023 (08:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0267.v1

A CNN-Based Approach for the Driver Drowsiness Detection by Real-Time Eye State Identification

Ruben Florez, Facundo Palomino-Quispe, Roger Jesus Coaquira-Castillo, Julio Cesar Herrera-Levano, Thuanne Paixão, Ana Beatriz Alvarez

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Driver Monitoring System; Drowsiness Detection; Convolutional Neural Network; Grad-CAM Visualization

Online: 5 June 2023 (08:26:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0269.v1

Low Prevalence of Schistosoma mekongi Infection Among Domestic Animals in Southern Lao People’s Democratic Republic

Somphou Sayasone, Phonepadith Khattignavong, Sengdeuane Keomalaphet, Phoyphaylinh Prasayasith, Pheovaly Soundala, Sannikone Sonesimmaly, Takashi Kumagai, Souk Phamhaksa, Phouth Inthavong, Bouasy Hongvanthong, Paul T TBrey, Shigeyuki Kano, Moritoshi Iwagami

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Schistosoma mekongi; LAMP; Reservoir Animal; Domestic animal; Lao PDR; Mekong River;

Online: 5 June 2023 (08:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0268.v1

Materials with Magnetic Iron Nanoparticles for Additive Manufacturing

Rocío Redón, Miriam Avila-Aviles, Leopoldo Ruiz-Huerta, Herlinda Montiel, Alex Elías-Zúñiga, Lucy-Caterine Daza-Gómez, Óscar Martínez-Romero

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Magnetic nanoparticles; cobalt ferrite; barium ferrite; additive manufacturing; VAT Photopolymerization

Online: 5 June 2023 (08:25:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0266.v1

A Comparative Analysis of Two-Phase Flow Boiling Heat Transfer Coefficient and Correlations for Hydrocarbons and Ethanol

Mohamed ElFaham, Clement C. Tang

Subject: Engineering, Mechanical Engineering Keywords: Flow boiling; Heat transfer coefficient; Two phase flow; hydrocarbons; Ethanol; Flow boiling correlations

Online: 5 June 2023 (08:21:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0265.v1

Detection and Genetic Characterization of Astroviruses in Brain Tissues of Wild Raccoon Dogs

Su-Beom Chae, Chang-Gi Jeong, Jun-Soo Park, Eun-Jee Na, Jae-Ku Oem

Subject: Biology And Life Sciences, Virology Keywords: astrovirus; wild raccoon dog; neurotropic-astrovirus

Online: 5 June 2023 (08:16:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0264.v1

The Coagulation Profile Monitoring of COVID-19 Patients with Standard and Viscoelastic Point of Care Hemostasis Tests

Milan Lazarević, Natalija Vuković, Dragan Milic, Aleksandar Kamenov, Velimir Peric, Mladjan Golubovic, Dimitrije Spasic, Vladimir Stojiljkovic, Marija Stosic, Dragana Stokanovic

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID 19; coagulation; viscoelastic tests; thrombosis; mortality

Online: 5 June 2023 (08:15:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0426.v2

Literature Review: Clinical Data Interoperability Models

Rachida Ait Abdelouahid, Olivier Debauche, Saïd Mahmoudi, Abdelaziz Marzak

Subject: Computer Science And Mathematics, Computer Science Keywords: Internet of Medical Things (IoMT); data exchange: healthcare; medical data; interoperability

Online: 5 June 2023 (08:12:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0186.v1

Age Estimation in Human Gait Extraction using A Combination of Multi-Energy Image with Invariant Moment

Nasser Al Musalhi, Erbuğ Çelebi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: age estimation; AFDEI; CNN; human gait; neural networks; GEI; invariant moments

Online: 5 June 2023 (08:12:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0263.v1

Cellular and Molecular Mechanisms of the Colorectal Cancer Tumor Stroma: Insights into Disease Progression and Therapeutic Targets

Nikolay Shakhpazyan, Liudmila Mikhaleva, Arcady L. Bedzhanyan, Zarina Gioeva, Nikolay Sadykhov, Alexander Mikhalev, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann, Alexander Orekhov

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Colorectal cancer; tumor stroma; gut microbiome; gut-associated lymphoid tissue; Wnt signaling pathway; tumor budding; Conserved Oncogenic Signatures; metastasis

Online: 5 June 2023 (08:09:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0262.v1

Improved DeepSORT-Based Object Tracking in Foggy Weather for AVs Using Sematic Labels and Fused Appearance Feature Network

Isaac Oluwadunsin Ogunrinde, Shonda Bernadin

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Multi-object tracking; DeepSORT; object detection; sensor fusion; deep learning, autonomous vehicles; radars; adverse weather; fog

Online: 5 June 2023 (08:09:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0257.v1

Ciprofloxacin-Loaded Polyvinylpyrrolidone Foils for the Topical Treatment of Wound Infections with Methicillin-Resistant Staphylococcus aureus (MRSA)

Fiorenza Rancan, Jana Jurisch, Sabrina Hadam, Annika Vogt, Ulrike Blume-Peytavi, Ilker S. Bayer, Marco Contardi, Christoph Schaudinn

Subject: Medicine And Pharmacology, Dermatology Keywords: wound dressing; drug delivery; organ culture, infection models, ciprofloxacin, infected wounds

Online: 5 June 2023 (08:09:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0261.v1

In-Hospital Rehabilitation of Patients with COVID-19: A Retrospective Study with Propensity Score Matching

Sergey M. Konev, Elisaveta S. Koneva, Teimurazi R. Matsonashvili, Ekaterina N. Zhumanova, Danil S. Malyutin, Natalia S. Serova, Evgeny E. Achkasov, Igor V. Semenyakin, Konstantin V. Lyadov, Irina A. Mandel, Andrey I Yaroshetskiy

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; early rehabilitation; computed tomography; physical exercises; chest massage in an electrostatic field.

Online: 5 June 2023 (08:06:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0260.v1

Deep Learning-Based Human Chromosome Classification: Data Augmentation and Ensemble

Mattia D'Angelo, Loris Nanni

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: chromosome classification; convolutional neural networks; ensemble; data augmentation

Online: 5 June 2023 (08:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1319.v2

Study of Attentional Networks of Alert, Orientation and Executive Control in Bilingual and Monolingual Primary School Children: The Role of Socioeconomic Status

Francesca Federico, Michela Mellone, Ferida Volpi, Margherita Orsolini

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: attention development; socioeconomic status; bilingualism; cognitive development

Online: 5 June 2023 (08:01:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0259.v1

COVID-19 Disease and Menstrual-Related Disturbances: A Spanish Retrospective Observational Study in Formerly Menstruating Women

María Gónzalez, Miriam Al-Adib, Ana B. Rodríguez, Cristina Carrasco

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: SARS-CoV-2 infection; COVID-19 disease; women´s health; menstrual-related disturbances; formerly menstruating women; secondary amenorrhea; perimenopause; heavy menstrual bleeding

Online: 5 June 2023 (07:58:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0252.v1

Prospective Cohort Study of Protective Effect of Neonatal Tuberculosis and Hepatitis B Vaccination against Development of Atopic Dermatitis: Interim Results of 18-Month Follow-Up

Marina Fedoseenko, Veronika Petrova, Leyla Namazova-Baranova

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: BCG; hepatitis B; vaccination; allergy; atopic eczema

Online: 5 June 2023 (07:57:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0258.v1

A Unified Spinor Description of the Photon and Electron Relativistic Fields

Pavel Gorev

Subject: Physical Sciences, Particle And Field Physics Keywords: quantum field theory; Minkowski space; electromagnetic potential calibration; Lorentz force; Casimir operators; wave equation; Dirac equation

Online: 5 June 2023 (07:55:10 CEST)

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We propose a description of the electromagnetic field in the form of a four-component complex spinor, from which a vector of electromagnetic potential with two degrees of freedom, calibrated by two conditions - zero length and zero component along the y-axis - is obtained by using Pauli matrices. A similar approach is applied to the field of a fermion, in particular, the electron. It is known that the quantum field of the electron and the electron itself is a four-component complex spinor, so, existing in the Minkowski vector space, we cannot observe it directly. But with the help of Pauli matrices a vector is formed from the electron spinor, which is known to us as an electric current vector, and this current vector describes exactly a single particle. As a vector, it is available to us for observation in our vector space. Similarly, the electromagnetic field and its photon particle is also a four-component spinor, from which the same formula using Pauli matrices produces a vector, it is known to us as the electromagnetic potential vector, and it too describes even a single photon. All the differences in the properties of the current vector and the electromagnetic potential vector, and hence the electron and the electromagnetic field, are due only to a slight difference in the structures of their four-component spinors and inextricable linked to them momentum spinors and coordinate spinors.Thus, a unified way to describe bosons and fermions in spinor space is proposed. The consequences of the Dirac equation for the electron spinor are considered and the existence of a similar first-order equation for the photon spinor is assumed. Each spinor by means of a uniform formula corresponds to a vector, in the case of a fermion it is a current vector, in the case of a boson it is a vector, for example, of the electromagnetic potential. Each spinor of a field is matched with a spinor of coordinates and a spinor of momentum, which are transformed by the same Lorentz transformations and which have the same structure as their corresponding field spinor, that is, the momentum and coordinates of boson have a bosonic spinor structure, while momentum and coordinates of fermion are a spinor with a fermionic structure. Field vectors, coordinates and momentum of boson automatically have a zero length, while in the case of fermion they all have a nonzero length, so the fermion, in contrast to the boson, has a nonzero mass, nonzero charge and moves with a sub light speed.The presented approach, in the long run, makes it possible to carry out calculations of the interaction of particles in two-dimensional spinor space, and to interpret in terms of the Minkowski vector space only the final results.

Preprint ARTICLE | doi:10.20944/preprints202306.0256.v1

How Czech Adolescents Perceive Their Physical Activity

Ferdinand Salonna, Michal Vorlíček, Josef Mitáš, Jana Vasickova, Lukáš Rubín, Dorota Kleszczewska

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: MVPA; VPA; social norms; children; adolescents; perception

Online: 5 June 2023 (07:47:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0255.v1

Quantum Effects in General Relativity: Investigating Repulsive Gravity of Black Holes at Large Distances

Piero Chiarelli

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: repulsive gravity; quantum black hole; dark energy

Online: 5 June 2023 (07:39:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0254.v1

Centella asiatica Lowers Body Fat Accumulation via Regulating Cholesterol Homeostasis- and Lipid Metabolism-Related Genes in Mice with High-Fat, High-Sugar Diet-Induced Obesity

Yeok Boo Chang, Yejin Ahn, Daebang Seo, Soohyun Bae, Hyung Joo Suh, Yang Hee Hong, Eun Young Jung

Subject: Public Health And Healthcare, Other Keywords: Centella asiatica; body weight; obesity; adipocyte

Online: 5 June 2023 (07:36:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0253.v1

Title Time-Series Analysis of Slope Displacements Using UAV Photogrammetry and Its Relationship With Rainfall Intensity

Byonghee Jun, Renato Macciotta, Namgyun Kim

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Slope displacement; UAV; DSM; Rainfall intensity

Online: 5 June 2023 (07:34:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0251.v1

Quantum Spacetime Geometrization in QED and Beyond: Towards the Standard Model

Piero Chiarelli

Subject: Physical Sciences, Particle And Field Physics Keywords: Quantum gravity; Quantum electrodynamics; Standard Model; quantum cosmology

Online: 5 June 2023 (07:27:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0250.v1

Novel Strategy for the Demulsification of Peanut Oil Body by Caproic Acid

Yuhang Gao, Yanzhao Zheng, Fei Yao, Fusheng Chen

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Peanut oil body; caproic acid; demulsification; oil quality

Online: 5 June 2023 (07:13:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0249.v1

Complexes of the Antibiotic Drug Oxolinic Acid with the Fe(III), Zn(II), Ca(II), and Mg(II) Ions: Preparation, Characterization, and In Vitro Evaluation of the Biological Activity

Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmed M. Naglah, Mashooq A. Bhat, Fhdah S. Alanazi, Fatimah A. Alotaibi, Moamen S. Refat, Abdel Majid A. Adam

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Oxolinic acid; Metal-based complex; Spectroscopy; Microscopic characterization; Antimicrobial activity.

Online: 5 June 2023 (07:09:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0241.v1

Overview of the Potential of Energy Harvesting Sources in Electric Vehicles

Said Bentouba, Nadjet Zioui, Peter Breuhaus, Mahmoud Bourouis

Subject: Engineering, Energy And Fuel Technology Keywords: electric vehicle; energy harvesting; thermal energy; mechanical energy

Online: 5 June 2023 (07:09:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0248.v1

Privacy-Preserving and Secure Solutions for Online English Education Platforms

Jiming Yin, Jie Cui

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: MIoTs; Software-defined MIoTs; Security; Signature; Authentication; Multicast; Online English Education

Online: 5 June 2023 (07:07:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0247.v1

A Novel Framework of Public Risk Assessment Using an Inte-Grated Approach Based on AHP and Psychometric Paradigm

Mahmaod Alrawad, Abdalwali Lutfi, Mohammed Amin Almaiah, Adi Alsyouf, Hussin Mostafa Arafa, Yasser Soliman, Ibrahim A. Elshaer

Subject: Social Sciences, Behavior Sciences Keywords: risk communication; resilience; psychometric paradigm; analytical hierarchal process.; risk perception; natural hazards

Online: 5 June 2023 (05:40:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0246.v1

On the Safety of Implanted Breast Prostheses in Accidental Impacts

Gerardus Janszen, Michela Arnoldi, Valeriano Vinci, Marco Klinger, Luca Di landro

Subject: Chemistry And Materials Science, Biomaterials Keywords: breast implants; silicone prosthesis aging; accidental impacts; crash test; compression tests

Online: 5 June 2023 (05:38:46 CEST)

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