Therapeutic Potential of Axolotl-Derived Neural Tissue Transplantation in Treating Cerebral Palsy: A Proposed Framework for Regenerative Medicine Research

Cerebral palsy (CP) is the most common form of motor disability in childhood, caused by nonprogressive brain damage occurring in fetal life or infancy. Although the current therapies mainly consist of symptomatic management using physical therapy, medications, and surgery, there is no cure. The proposed study will be the first to use a novel therapy involving the use of the axolotl's neural tissue for transplantation into the damaged areas of the motor cortex of patients suffering from cerebral palsy. The axolotl, whose scientific name is Ambystoma mexicanum, has the unique ability to regenerate its brain and neural tissues, including the variety of cells, the complexity, and the functional circuits. This paper will provide a thorough analysis of the proposed study, including the rationale, proposed procedure, challenges, and proposed research pathway. Although there seem to be many challenges, including the difference in immune systems, the advancements that have been made recently in the field of tissue engineering, immunosuppression, and the understanding of the axolotls' regenerative ability make it imperative to pursue this novel therapy. The ultimate goal of this research is to provide sufficient evidence to be able to submit a research proposal to research review and ethic boards to enable the conduct of the research.