Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Pathophysiology of Virulence of the COVID-19 Virus

Version 1 : Received: 3 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (02:40:24 CEST)
Version 2 : Received: 14 April 2020 / Approved: 15 April 2020 / Online: 15 April 2020 (08:08:52 CEST)

How to cite: De Soto, J.; Hakim, S.; Boyd, F. The Pathophysiology of Virulence of the COVID-19 Virus. Preprints 2020, 2020040077 (doi: 10.20944/preprints202004.0077.v1). De Soto, J.; Hakim, S.; Boyd, F. The Pathophysiology of Virulence of the COVID-19 Virus. Preprints 2020, 2020040077 (doi: 10.20944/preprints202004.0077.v1).

Abstract

Background: On Dec 19, 2019 it was reported by the public health department of China that an outbreak of pneumonia was caused by a novel Coronavirus. The virulence of the new virus COVID-19 was much greater than either the SARs or MERSs viruses and on March 11, 2020 the World Health Department (WHO) declared world -wide pandemic. Understanding the pathophysiology of virulence of the COVID-19 virus is absolutely necessary in understanding the transmission, virulence factors, reduce risk factors, clinical presentation, predict outcomes of the disease and provide guidance to any current or future treatment protocols. Methodology: A PubMed search was performed utilizing the words: Wuhan Virus, COVID-19, SARs coronavirus, ACE2, S protein, virulence, clinical presentation, epidemiology, genome, treatment, structure, MERs, pathogenesis and/or pathology alone and in combination with other terms. Each paper was evaluated by three content experts for quality, reproducibility, credibility and reputation of the journal. Results: The COVID-19 virus is much more virulent than either the SARs or MERs virus and its ability to cause serious disease inversely corresponds to the person’s ability to produce T-cells which declines linearly with age. The ACE2 receptor binding site do not vary among different ethnic groups but do in expression levels. This variance in expression level may explain for different infectivity rates among men and women and predict and explain different susceptibilities to infection by different ethnic groups. Furthermore, by understanding the underlying pathophysiology one can explain and provide guidance to the clinical effectiveness of any treatment. Conclusions: The underlying pathophysiology of COVID-19 explains not only the virulence, and clinical presentation, but, explains at a molecular level the comorbidity risk factors such as hypertension, sex, and age. Ethnic and anatomic expression patterns of ACE-2 and associated pathophysiology suggests that Native Americans and Asians may be particularly susceptible to this disease.

Subject Areas

COVID-19; native American Indian; treatment; ACE2 receptor; pathophysiology; virulence

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