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Preprint ARTICLE | doi:10.20944/preprints202211.0313.v1

Binding of Specific S100 Proteins Inhibits Activity of Tumor Necrosis Factor

Alexey S. Kazakov, Marina Y. Zemskova, Gleb K. Rystsov, Alisa A. Vologzhannikova, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Subject: Biology And Life Sciences, Biophysics Keywords: cytokine; Tumor necrosis factor; S100 protein; protein–protein interaction; inflammatory diseases

Online: 16 November 2022 (13:12:59 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202306.2240.v2

An Atypical Presentation of Superficial Breast Cancer: A Case Report and Review of the Literature

Paolo Izzo, Luciano Izzo, Andrea Polistena, Simone Sibio, Massimo Codacci-Pisanelli, Daniele Crocetti, Raimondo Gabriele, Claudia De Intinis, Sara Izzo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: retroareolar breast tumor; modified radical mastectomy; case report; triple negative breast cancer (TNBC); chemotherapy; superficial infiltrating breast carcinoma; taxol

Online: 7 August 2023 (02:30:15 CEST)

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Working Paper ARTICLE

Cancer Testis Antigens and Immunotherapy: Expression of PRAME and NY-ESO-1 Predicts Survival in Soft Tissue Sarcoma

Markus Albertsmeier, Annelore Altendorf-Hofmann, Lars H. Lindner, Rolf D. Issels, Eric Kampmann, Hans-Roland Dürr, Gabriele Schubert-Fritschle, Martin K. Angele, Thomas Kirchner, Achim A. Jungbluth, Thomas Knösel

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: soft tissue sarcoma; human; cancer/testis antigens; PRAME; NY-ESO-1; SSX2; biomarker; tumor infiltrating lymphocytes; immunohistochemistry

Online: 25 July 2020 (11:23:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1347.v1

Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti‐Tumor Immunity

Suguru Saito, Duo-Yao Cao, Toshio Maekawa, Noriko Tsuji, Alato Okuno

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: probiotics; macrophage; anti‐tumor immunity; glycolysis; ATP

Online: 19 April 2024 (15:22:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0706.v1

Neuroendocrine Tumor Chromogranin A Response following Synthetic Somatostatin analog (Lanreotide): First Observations from an Isolated Duodenal Neoplasm

E. Scott Sills, Samuel H. Wood, Seang Lin Tan, Daniel M. Ibach

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: neuroendocrine tumor; duodenum; chromogranin A; lanreotide; surgery

Online: 11 July 2023 (10:14:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0227.v1

Environmental Enrichment in Cancer: A Possible Tool to Combat Tumor Development: A Systematic Review

Matheus Santos Fernandes, Tiago Ramos Lacerda, Débora Eduarda da Silva Fidelis, Gabriela Carvalho Jurema Santos, Tayrine Ordonio Filgueira, Raphael Fabrício De Souza, Claúdia Jacques Lagranha, Fábio Santos Lira, Angela Castoldi, Fabricio Oliveira Souto

Subject: Biology And Life Sciences, Life Sciences Keywords: Enriched Environment; Cancer; Tumor growth; angiogenesis; pro-oncogenic factor

Online: 4 October 2023 (09:35:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1845.v1

Differences in the Tumor Molecular and Microenvironmental Land-Scape Between Early (Non-metastatic) and De Novo Metastatic Primary Luminal Breast Tumors

Yentl Lambrechts, Sigrid Hatse, François Richard, Bram Boeckx, Giuseppe Floris, Christine Desmedt, Ann Smeets, Patrick Neven, Diether Lambrechts, Hans Wildiers

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: (luminal) breast cancer; breast cancer biology; mutations; primary tumor; de novo - stage IV; tumor microenvironment

Online: 27 June 2023 (04:47:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0036.v1

Z2-$\gamma$: an Application of Zienkiewicz-Zhu Error Estimator to Brain Tumor Detection in MR Images

Antonella Falini

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: brain tumor detection; finite-elements; adaptivity; morphological transformation

Online: 2 September 2022 (09:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0211.v1

Particle Swarm Optimization and Two-Way Fixed-Effects Analysis of Variance for Efficient Brain Tumor Segmentation

Naoual Atia, Amir Benzaoui, Sébastien Jacques, Madina Hamiane, Kaouther El Kourd, Ayache Bouakaz, Abdeldjalil Ouahabi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Brain tumor; Image segmentation; PSO; ANOVA, K-means.

Online: 14 July 2022 (11:28:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0263.v1

Cellular and Molecular Mechanisms of the Colorectal Cancer Tumor Stroma: Insights into Disease Progression and Therapeutic Targets

Nikolay Shakhpazyan, Liudmila Mikhaleva, Arcady L. Bedzhanyan, Zarina Gioeva, Nikolay Sadykhov, Alexander Mikhalev, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann, Alexander Orekhov

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Colorectal cancer; tumor stroma; gut microbiome; gut-associated lymphoid tissue; Wnt signaling pathway; tumor budding; Conserved Oncogenic Signatures; metastasis

Online: 5 June 2023 (08:09:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1620.v1

Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumor for Approaching the Novel Research Animal Model

Taehee Min, Sang-Hee Lee, Seunghyung Lee

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: ovary; corpus luteum; tumor; angiogenesis; apoptosis

Online: 28 February 2024 (09:50:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0598.v1

Kyogo Itoh, Shigeki Shichijo, Shigetaka Suekane

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: anti-tumor immunity; antigenic mimicry; CTL epitope peptides; human tumor-associated antigens; intestinal microbiota; linear sequence analysis; TCR-mediated recognition analysis

Online: 10 October 2023 (08:31:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0843.v1

Lipid Nanoparticle (LNP) Delivery Vector-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

Liusheng Wu, Xiaoqiang Li, Xinye Qian, Shuang Wang, Jixian Liu, Jun Yan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Lipid nanoparticles (LNPs); mRNA vaccine; Tumor immunity; Delivery vector; Review

Online: 13 December 2023 (03:35:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0583.v1

C-met+ CTLs Exhibit Enhanced Cytotoxicity in Mouse and Human In Vitro Tumor Models

Mahdia Benkhoucha, Ngoc Lan Tran, Isis Senoner, Gautier Breville, Hajer Fritah, Denis Migliorini, Valérie Dutoit, Patrice H. Lalive

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: c-Met; HGF; CTLs; CD8+ cytotoxic T lymphocytes; spheroids; tumor

Online: 10 October 2023 (08:09:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0355.v1

Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying the Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP⁵⁺ (BMX-001)

Sun Up Noh, Jinyeong Lim, Sung-Won Shin, Yeeun Kim, Woong-Yang Park, Ines Batinic-Haberle, Changhoon Choi, Won Park

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Mn porphyrin clinical candidate, MnTnBuOE-2-PyP⁵⁺ (BMX-001, MnBuOE); Single-cell RNA sequencing; Tumor heterogeneity; Tumor microenvironment; Radiotherapy; Tumor radiosensitization

Online: 6 February 2024 (09:43:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2143.v1

Development of Novel Bioluminescent Biosensors Monitoring Conformation and Activity of Merlin Tumor Suppressor

Alex Pipchuk, Tynan Kelly, Madeleine Carew, Christopher Nicol, And Xiaolong Yang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hippo Pathway; Merlin; tumor suppressor; Biosensor; NanoLuc; NanoBiT; Cell contact inhibition

Online: 28 December 2023 (05:31:44 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202402.0130.v2

Nodular Neurogenic Tumor of the Tip of the Tongue

Charlotte Berge, Hilal Hafian, Anne Durlach

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Benign nerve sheath tumors; Abrikossoff’ s tumor; granular cell; oral pathologist; peripheral nerve disorders; tongue; s100 protein

Online: 5 February 2024 (05:35:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1586.v1

Integrated Genomic Analysis of Primary Prostate Tumor Foci and Corresponding Lymph Node Metastases Identifies Mutations and Pathways Associated with Metastasis

Carlos S. Moreno, Cynthia L. Winham, Mehrdad Alemozaffar, Emma R. Klein, Ismaheel O. Lawal, Olayinka A. Abiodun-Ojo, Dattatraya Patil, Benjamin G. Barwick, Yijian Huang, David M. Schuster, Martin G. Sanda, Osunkoya O. Adeboye

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cancer Genomics; Metastasis; Prostate Cancer; Tumor Heterogeneity

Online: 25 October 2023 (05:15:54 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202207.0294.v1

Comparative Study of Convolution Neural Network with GLCM Approach and Superpixel based Spectral Clustering for Brain Tumor Detection

Gagandeep Kaur, Shivani Sharma

Subject: Computer Science And Mathematics, Computer Science Keywords: CNN; brain tumor; GLCM; segmentation; superpixel; spectral clustering

Online: 20 July 2022 (05:28:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0357.v1

Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review

Zhijia Peng, Xiaogang Lin, Weiqi Nian, Xiaodong Zheng, Jayne Wu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: non-destructive; biosensors; real-time detection; circulating tumor DNA (ctDNA); high sensitivity; Internet of Things

Online: 19 November 2021 (14:28:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0758.v1

Correlation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment

Mr Tufael, Auditi kar, Vijay Jagdish Upadhye, Atiqur Rahman Sunny, Antonio Raposo, Md. Saidul Islam, Md Haroon Or Rashid, Mohammad Anowar Hussen, Heesup Han, Henrique Douglas Melo Coutinho, Md. Sefaul Ullah, Md. Mizanur Rahman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hepatocellular carcinoma; Tumor markers; Chemiluminescence assay; Occupational exposure; Early diagnosis

Online: 10 January 2024 (05:44:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0315.v1

Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana: A Mini-Review

Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Nicotiana; alkaloids; anti-tumor; metabolic engineering; de-novo synthesis ;

Online: 13 April 2023 (08:53:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0592.v1

Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products

Xiaoye Liu, Hongwei Xu, Yuting Feng, Xiaolin Hou

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: anticancer drugs; mechanical microenvironment; tumor stiffness; cytoskeleton dynamics; material approaches

Online: 26 July 2021 (15:42:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0086.v1

Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications

Philip Salu, Katie M. Reindl

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Circulating tumor cells; liquid biopsy; cancer research; metastasis; personalized medicine; single-cell sequencing; biomarkers.

Online: 4 March 2024 (09:27:46 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.0083.v1

Collision Tumors of the Colon and Peritoneum: Signet-Ring Carcinoma and Granular Cell Tumor

Dorela-Codruta Lazureanu, Denisa Anderco, Sorin Dema, Aura Jurescu, Remus Cornea, Octavia Vita, Bogdan Tunescu, Sorina Taban

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: abdominal collision tumors; colon signet-ring carcinoma; peritoneal granular cell tumor

Online: 2 November 2023 (06:51:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0983.v1

Brain Tumor Detection using the VGG-16 Model: A Deep Learning Approach

Dheiver Santos

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: brain tumor detection; VGG-16 model; convolutional neural network; MRI imaging; deep learning

Online: 14 August 2023 (08:34:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0544.v1

Advancing GCT Management: A Review of miR-371a-3p and Other miRNAs in Comparison to Traditional Serum Tumor Markers

Crystal L Seales, Dhruv Puri, Nuphat Yodkhunnatham, Kshitij Pandit, Kit Yuen, Sarah Murray, Jane Smitham, John T Lafin, Aditya Bagrodia

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Germ Cell Tumors; Biomarkers; Serum Tumor Markers; miRNAs

Online: 10 March 2024 (17:02:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0421.v3

Drawbacks of Immune Checkpoint Inhibition and Rigorous Management for Immune Related Adverse Events Along with a Mathematical Model to Assess Therapy Success and Optimum Therapy Duration and a Strategy Against Tumor Plasticity

C. Mehmet Hendekli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oncology; Immune Checkpoint Inhibition; PD-1; PD-L1; CTLA-4; Immune Related Adverse Events; Immunotherapy; Tumor Plasticity; Tumor Microenvironment; Optimum Therapy Duration

Online: 6 March 2023 (01:53:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0003.v1

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3 and Reducing STAT3

Chiharu Sogawa, Manh Tien Tran, Masayuki Ishige, Kilian Trin, Yuka Okusha, Eman Ahmed Taha, Yanyin Lu, Hotaka Kawai, Norio Sogawa, Masaharu Takigawa, Stuart K. Calderwood, Kuniaki Okamoto, Ken-ichi Kozaki, Takanori Eguchi

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: drug repositioning/repurposing; dopamine transporter (DAT); benztropine; tumoroids; signal transducer and activator of transcription (STAT); circulating tumor cells (CTC); three-dimensional (3D) culture

Online: 3 February 2020 (03:16:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0571.v1

Unselective Measurement of Tumor‐to‐Stroma Proportion in Colon Cancer at the Invasion Front– an Elusive Prognostic Factor. Original Patient Data and Review of the Literature

Zsolt Fekete, Patricia Ignat, Amelia Cristina Resiga, Nicolae Todor, Alina-Simona Muntean, Liliana Resiga, Sebastian Curcean, Gabriel Lazar, Alexandra Gherman, Dan Eniu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: fibrosis; tumor stroma; stroma to tumor ratio; pathology markers; colon cancer; adjuvant treatment; invasion front

Online: 8 April 2024 (14:35:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0573.v1

A Surgical Pen-Type Probe Design for Real-Time Optical Diagnosis of Tumor Status using 5-Aminolevulinic acid

Ki-Cheol Yoon, Kwang Gi Kim, Seung Hoon Lee

Subject: Engineering, Automotive Engineering Keywords: fluorescence microscopy; fluorescence emission, malignant tumor, diagnosis, animal experiment

Online: 21 April 2021 (11:47:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0167.v1

Convolutional Neural Network Techniques for Brain Tumor Classification (from 2015 to 2021): Review, Challenges, and Future Perspectives

Yuting Xie, Fulvio Zaccagna, Leonardo Rundo, Claudia Testa, Raffaele Agati, Raffaele Lodi, David Neil Manners, Caterina Tonon

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: deep learning; convolutional neural network; brain tumor classification; clinical application

Online: 13 June 2022 (04:57:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0371.v1

Knockout of MMP3 Weakened Solid Tumor Organoids and Cancer Extracellular Vesicles

Eman A. Taha, Chiharu Sogawa, Yuka Okusha, Hotaka Kawai, May Wathone Oo, Abdellatif El-Seoudi, Yanyin Lu, Hitoshi Nagatsuka, Satoshi Kubota, Ayano Satoh, Kuniaki Okamoto, Takanori Eguchi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: matrix metalloproteinase 3 (MMP3); extracellular vesicles (EVs); tumoroid; tumor organoid; tumorigenesis; three-dimensional (3D) culture system

Online: 25 March 2020 (05:25:09 CET)

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The tumor organoid (tumoroid) model in three-dimensional (3D) culture systems has been developed to reflect more closely the in vivo tumors than 2D-cultured tumor cells. Notably, extracellular vesicles (EVs) are efficiently collectible from the culture supernatant of gel-free tumoroids. Matrix metalloproteinase (MMP) 3 is a multi-functional factor playing crucial roles in tumor progression. However, roles of MMP3 within tumor growth and EVs have not unveiled. Here, we investigated the protumorigenic roles of MMP3 on integrities of tumoroids and EVs. We generated MMP3-knockout (KO) cells using the CRISPR/Cas9 system from rapidly metastatic LuM1 tumor cells. Moreover, we established fluorescent cell lines with palmitoylation signal-fused fluorescent proteins (tdTomato and enhanced GFP). Then we confirmed the exchange of EVs between cellular populations and tumoroids. LuM1-tumoroids released large EVs (300-1000 nm) and small EVs (50-200 nm) while the knockout of MMP3 resulted in the additional release of broken EVs from tumoroids. The loss of MMP3 leads to a significant reduction in tumoroid size and to the development of the necrotic area within tumoroids. MMP3 and CD9 (a category-1 EV marker tetraspanin protein) were significantly down-regulated in MMP3-KO cells and their EV fraction. These weakened phenotypes by MMP3 KO were markedly rescued by the addition of MMP3-rich EVs or conditioned medium (CM) collected from LuM1-tumoroids, which caused a dramatic rise in the expression of MMP3, CD9, and Ki-67 (a marker of proliferating cells) in the MMP3-null/CD9-low tumoroids. Notably, MMP3 enriched in tumoroids-derived EVs and CM deeply penetrated into recipient MMP3-KO tumoroids, resulting in a remarkable enlargement of solid tumoroids, while MMP3-null EVs did not. These data demonstrate that EVs can mediate molecular transfer of MMP3 resulting in increasing the proliferation and CD9+ tumorigenesis, indicating crucial roles of MMP3 in tumor progression.

Preprint ARTICLE | doi:10.20944/preprints202306.0342.v1

A Comparative Study of Tumor-Specificity and Neurotoxicity Between 3-Styrylchromones and Anticancer Drugs

Tomoyuki Abe, Hiroshi Sakagami, Shigeru Amano, Shin Uota, Kenjiro Bandow, Yoshihiro Uesawa, Shiori U, Hiroki Shibata, Yuri Takemura, Yu Kimura, Koichi Takao, Yoshiaki Sugita, Akira Sato, Sei-ichi Tanuma, Hiroshi Takeshima

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: chromone derivatives; oral squamous cell carcinoma; tumor-specificity; keratinocyte toxicity; neurotoxicity; signaling pathway

Online: 5 June 2023 (15:45:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0082.v1

Purinergic Receptors Are a Key Bottleneck in Tumor Metabolic Reprogramming: The Prime Suspect in Cancer Therapeutic Resistance

Hamid Aria, Marzieh Rezaei, Shima Nazem, Abdolreza Daraei, Ghasem Nikfar, Behnam Mansoori, Maryam Bahmanyar, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: therapy resistance; tumor microenvironment; metabolic reprogramming; purinergic receptor; cancer metabolism; immunometabolism

Online: 3 August 2022 (10:35:30 CEST)

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Working Paper ARTICLE

Coincubation as miR-Loading Strategy to Improve the Anti-Tumor Effect of Stem Cell-Derived EVs

Alessia Brossa, Marta Tapparo, Valentina Fonsato, Elli Papadimitriou, Michela Delena, Giovanni Camussi, Benedetta Bussolati

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: extracellular vesicle engineering; microRNA; loading; anti-tumor; cancer stem cells; exosomes; coincubation

Online: 10 December 2020 (10:34:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0437.v1

Modulation of ATP8B1 Gene expression in Colorectal Cancer Cells Suggest its Role as a Tumor Suppressor

Saleh Althenayyan, Amal AlGhamdi, Mohammed H AlMuhanna, Esraa Hawsa, Dalal Aldeghaither, Jahangir Iqbal, Sameer Mohammad, Mohammad Aziz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Colorectal cancer; flippase; ion transporter; tumor suppressor gene; chromosome 18q; lipid transport

Online: 16 November 2020 (17:09:08 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0140.v1

Krukenberg's Tumor as an Incidental Finding in a Full-Term Pregnancy: A Case Report

Orlando Andres Nunez-Isaac, Felipe Mendoza-Rosado, Katheryn Lopez-Arjona, Alan Espinosa-Marron, Fernando Davila-Martinez

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Krukenberg Tumor; Neoplasm Metastasis; Ovarian Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Case Report.

Online: 11 June 2020 (12:30:50 CEST)

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BACKGROUND Krukenberg tumor is a rare metastatic tumor of the ovary with characteristic histopathological features known as signet-ring cells. It usually presents in women around 45 years of age, however, we present an uncommon case in a 38-year-old pregnant woman. We report this case because of the unusual findings, the uncommon presentation in this younger age bracket, its diagnostic challenge, and poor prognosis. CASE PRESENTATION We describe an unusual case of a young woman with a history of painful vaginal bleeding at 13 weeks of pregnancy and treated for abruptio placentae. In her routine prenatal visit at week 20 of pregnancy, she was found to have a uterine fundus greater than her gestational age and referred to the hospital to discard polyhydramnios. At her admission a pelvic ultrasound was performed with normal findings of a 25 weeks pregnancy, also showing bilateral enlarged ovaries with heterogeneous echogenicity. The MRI showed a left tumoral lesion with dimensions of 22.1 x 13.6 x 16.3 cm, with lobulated regular contours with displacement of peripheral structures and mild compression of the bladder, the left ureter, and the inferior vena cava. The lesion was heterogeneous with irregular borders. The patient was programmed for a cesarean section; during the operation, the abdominal cavity showed bilateral tumors compatible with MRI findings, the ovarian tumors were sent to pathology and the results showed poorly differentiated mucinous adenocarcinoma (WHO III) with extensive signet-ring cells, an indicative of Krukenberg tumor. CONCLUSION: The case presented is rare due to its presentation in a pregnant woman without identifiable risk factors for gastric cancer. The incidental finding suggests the pregnancy masked the clinical presentation of gastric cancer, and the rapid deterioration of the patient is consistent with the aggressiveness described in the literature. The limited descriptions of this neoplasm in our country and the torpid evolution of this case highlight the importance of further studies of this cancer in Mexico.

Preprint COMMUNICATION | doi:10.20944/preprints202402.1700.v2

Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions

Mitsuhiro Tachibana, Hideki Hamayasu, Akihiko Yokota, Masahiro Matsushita

Subject: Biology And Life Sciences, Life Sciences Keywords: hyperplastic nodule; polypoid lesion; colitis nucleomigrans; colorectal mucosa; tumor-like lesion

Online: 29 March 2024 (17:10:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0325.v1

Foxp3 and CD68 as Potential Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Solid Tumor

Peter Grell, Simona Borilova, Pavel Fabian, Iveta Selingerova, David Novak, Petr Muller, Igor Kiss, Rostislav Vyzula

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Immune checkpoint inhibitors; Anti-tumor immunity; Predictive biomarker; Malignant melanoma; NSCLC

Online: 18 January 2023 (08:39:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0223.v1

Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells through Inhibition of Human Endogenous Retrovirus Type K

Jiayi Li, John Lin, John Ryan Lin, Mason Farris, Lauren Robbins, Leo Andrada, Bryce Grohol, Serratt Nong, Yingguang Liu

Subject: Biology And Life Sciences, Virology Keywords: endogenous retroviruses; HERV-K; mouse mammary tumor virus; dolutegravir; 4T1 cells

Online: 18 February 2022 (05:10:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0729.v2

The Undervalued Avenue to Reinstate Tumor Suppressor Functionality of the p53 Protein Family for Improved Cancer Therapy - Drug Repurposing

Joanna E Zawacka-Pankau

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: p53; p73; MDM2; MDMX; tumor suppressor; drug repurposing; aspirin; protoporphyrin IX; verteporfin

Online: 17 September 2020 (07:23:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0795.v1

Advances in Cellular Immunotherapy: Understanding and Preventing T-cell Dysfunction

Valérie Janelle, Jean-Sébastien Delisle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: T cells; chimeric antigen receptor; transgenic T-cell receptor; tumor-infiltrating lymphocytes; exhaustion; terminal differentiation; senescence; apoptosis; adoptive cell transfer; immunotherapy

Online: 31 December 2020 (12:16:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1760.v1

Precise Detection and Transcriptomic Concordant Analysis of Circulating Tumor Cells from Prostate Cancer

Hyungseok Cho, Ki-Ho Han, Jae-Seung Chung, Seok-Soo Byun, Jae Il Chung, Won Ik Seo, Chan Ho Lee

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; circulating tumor cells; lateral magnetophoresis; prostate-specific antigen; prostate-specific membrane antigen; biomarker; liquid biopsy

Online: 27 October 2023 (08:17:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0960.v1

Bridging the Gap: Exploring Interpretability in Deep Learning Models for Brain Tumor Classification from MRI Images

Wandile Nhlapho, Marcellin Atemkeng, Yusuf Brima, Jean-Claude Ndogmo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: transfer learning; deep learning; brain tumor classification; explanability and interpretability; Grad-Cam++; integrated gradients

Online: 19 February 2024 (10:21:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1767.v1

Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study

Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; tumor marker; atezolizumab plus bevacizumab; prognosis; predictive model

Online: 26 June 2023 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1167.v1

Discovery of Novel Potential Prognostic Marker and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced Stage Wilms’ Tumor

Pongsakorn Choochuen, Natakorn Nokchan, Natthapon Khongcharoen, Wison Laochareonsuk, Komwit Surachat, Thirachit Chotsampancharoen, Thanit Sila, Surasak Sangkhathat

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Wilms’ tumor; Chemotherapy resistance; Biomarkers; Somatic mutation; Targeted therapy; Cancer-driver mutation

Online: 17 April 2024 (15:03:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0170.v1

Assessment of NF-κB Inhibitor (SN50) Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression

Nasser M. Al-Dagheri, Assim A. Alfadda, Reem M. Sallam, Philip G. McTernan, Lotfi S. Bin Dahman

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: abdominal subcutaneous adipocytes; angiotensinogen; nuclear factor-kappa B; lipopolysaccharide; tumor necrosis factor-alpha

Online: 6 April 2021 (11:28:00 CEST)

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Central adiposity is one of the significant determinants of obesity-related hypertension risk, which may arise due to the abdominal fat depot's pathogenic inflammatory nature. Pro-inflammatory cytokines and adipokines up-regulation through nuclear factor-kappa B (NF-κB) activation in adipose tissue has been considered an essential function in the pathogenesis of obesity-related hypertension. This study aimed to ascertain the NF-κB inhibitor (SN50) effect on TNF-α and angiotensinogen (AGT) secretion and expression in mediating the anti-inflammatory effect through its impact on NF-κB activity in humans adipose tissue. Primary human adipocytes were isolated from 20 subjects among 10 overweight and 10 obese with and without hypertension and treated with 10ng/ml LPS in the presence and absence of NF-κB inhibitor, SN50 (50μg/ml). TNF-α secretion and NF-κB p65 activity were detected in supernatants extracted from cultured cells treated and untreated with LPS (10ng/ml) and SN50 (50μg/ml) using enzyme-linked immunosorbent assay (ELISA). The western blot technique detected the protein of NF-κB p65 and AGT. Gene expression of TNF-α and AGT was detected in cells and performed using quantitative real-time polymerase chain reaction (RT-PCR). Treatment of AbdSc adipocytes with LPS (10ng/ml) caused a significant increase in NF-κB p65 among overweight and obese subjects with and without hypertension (P= 0.001) at 24 hours incubation. In contrast, SN50-NF-κB inhibitor causes a reduction of NF-κB p65 in overweight (P= <0.001) and obese subjects with and without hypertension (P= 0.001) at 24 hours incubation. Treatment of AbdSc adipocytes with 10ng/ml LPS caused a significant increase in TNF-α secretion in overweight and obese subjects at all-time points (P= <0.001), whereas SN50 leads to a decrease in TNF-α secretion at 3 and 12 hours incubation. Treatment of AbdSc adipocytes with LPS (10ng/ml) caused increased TNF-α and AGT gene expression twofold compared with untreated cells, whereas, in the presence of SN50, it reduces mRNA AGT levels in both groups. Taken together, these adipokines with NF-κB activation may represent essential biomarkers to evaluate hypertension risk and to provide insight into the pathogenesis of obesity-related hypertension.

Preprint REVIEW | doi:10.20944/preprints202012.0288.v1

Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy

Celso Abdon Mello, Fernando Augusto Batista Campos, Tiago Goss Santos, Maria Leticia Gobo Silva, Giovana Tardin Torrezan, Felipe D´Almeida Costa, Maria Nirvana Formiga, Ulisses Nicolau, Antonio Geraldo Nascimento, Cassia Silva, Suely Nakagawa, Maria Paula Curado, Ademar Lopes, Samuel Aguiar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: desmoplastic small round cell tumor; treatment; prognosis; surgery; radiotherapy; chemotherapy; tyrosine kinase receptor; target therapy; rare disease

Online: 11 December 2020 (15:53:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0370.v1

Intraoperative Cryosurgical Freezing Assists with Local Drug Delivery and Targeting of Tumor Fluids in VX2 Model, which Translates in Locoregional Drug Targeting of Tumor Fluids during Cryoprobe-Assisted Surgical Resection of Breast Cancer

Patrick Le Pivert, Yueyong Xiao, Xiaofeng He, Olexeii Dronov, Nikolai Korpan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Targeted drug delivery, VX2 tumor, breast cancer, cryoablation, cryo-assisted injection, cryo-assisted resection, blue dye, epirubicin.

Online: 30 May 2019 (13:44:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0325.v2

Streptavidin-Modified Iron Oxide Hybrid Nanozymes for Magnetic Enrichment and Bioelectrocatalytic Sensing of Circulating Tumor RNA

Kevin M. Koo

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanozymes; circulating tumor nucleci acid; liquid biopsy; magnetic enrichment; minimal residual disease; cell-free RNA

Online: 24 October 2022 (10:33:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0368.v1

Finding Waldo: The Evolving Paradigm of Circulating Tumor DNA (ctDNA)-Guided Minimal Residual Disease (MRD) Assessment in Colorectal Cancer (CRC)

Sakti Chakrabarti, Anup Kasi, Aparna Raj Parikh, Amit Mahipal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: circulating tumor DNA; colon cancer; colorectal cancer; minimal residual disease; adjuvant chemotherapy

Online: 27 May 2022 (03:52:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0046.v1

Tumor Transcriptome in Patients with Lower Pectoralis Muscle Area Reveals IL-8 as a Prognostic Biomarker in Non-Small Cell Lung Cancer

Sarah Santiloni Cury, Diogo de Moraes, Paula Paccielli Freire, Grasieli de Oliveira, Douglas Venâncio Pereira Marques, Geysson Javier Fernandez, Maeli Dal-Pai-Silva, Érica Nishida Hasimoto, Patricia Pintor dos Reis, Silvia Regina Rogatto, Robson Francisco Carvalho

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: secretome; computed tomography; interleukin-8; tumor-derived factor; C2C12 cells; Cachexia

Online: 3 July 2019 (06:41:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0013.v1

The Reversal Effect of P-Glycoprotein-Mediated Tumor Multidrug Resistance by Pyxinol and 24S-Pyxinol Amino Acid Ester Derivatives

Luying Tan, Peng Gao, Zhuoqiao Li, Chencheng Gao, Xiaoyu Geng, Qianyun Wang, Daohao Tang, Fang Wang, Jinping Liu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: tumor multidrug resistance; P-glycoprotein; pyxinol amino acid ester derivatives; molecular docking; metabolomics

Online: 1 October 2023 (08:32:50 CEST)

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(1) Background: The typical transporter protein, P-glycoprotein (P-gp), has been proven to be associated with multidrug resistance (MDR). Pyxinol and 24S-Pyxinol amino acid ester derivatives had been demonstrated to be promising P-gp inhibitors for reversal of tumor MDR in KBV cells, however, their roles in MDR reversal in other tumor-resistant cells are still unclear. (2) Methods: In the present study, we synthesized 40 amino acid ester derivatives of Pyxinol and 24S-Pyxinol. The MDR reversal effects of these derivatives were evaluated in A549/Tax, MCF-7/ADR, and HCT-8/VCR cells using the CCK-8 assay. Subsequently, western blot assay, intracellular Rhodamine123 (Rh123) accumulation assay and P-gp ATPase activity assay were utilized to investigate the effects of active compound on P-gp. Molecular docking was used to predict the possible binding patterns of active compound to P-gp. Moreover, based on UPLC-Q/TOF-MS cellular metabolomics technology to identify endogenous differential metabolites and metabolic pathways associated with tumor MDR effects of the active compound. (3) Results: The results of the CCK-8 assay showed that compounds 8, 14, 16, 17, 18, 23, 25, 34, 36, 37 exhibited strong MDR reversal effect in A549/Tax, MCF-7/ADR and HCT-8/VCR cells, which were screened by reversal fold (RF) greater than 5. Among them, 10 μM of derivative 37 (new compound) showed the outstanding activity (RF: 15.31) in reversing MDR in A549/Tax cells. Compound 37 could act as a substrate for P-gp and inhibit the efflux function of P-gp by competitively binding to the binding site of antitumor drugs. Meanwhile, the molecular docking results confirmed that compound 37 was identified to under-go high-affinity binding to the drug binding site of P-gp. In addition, 14 endogenous differential metabolites and 6 metabolic pathways involved closely associated with the reversal of tumor MDR effects of compound 37 were identified. (4) Conclusions: Overall, a new candidate compound 37 (24S-3-L-threonyl-Pyxinol) could be provided for reversing tumor MDR by this study.

Preprint ARTICLE | doi:10.20944/preprints202308.0888.v1

Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation using a UNet-PWP Deep Learning Model on CT Scan Images

Patike Kiran Rao, Dr Subarna Chatterjee, Dr M Janardhan, Dr Nagaraju K, Dr. Surbhi Bhatia Khan, Dr. Ahlam Almusharraf, Abdullah I Alharbe

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Distirubtion Strategy; UNet-P model; Kidney tumor; Segmentation; Adaptive Partitioning; Optimization; Weight Pruning

Online: 11 August 2023 (07:08:11 CEST)

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Motivation: It is essential for the diagnosis and treatment of renal cancers to segment kidney tumours precisely and effectively. In medical image segmentation tasks, deep learning models have demonstrated promising results, and the UNet model is widely employed in this field. However, optimising the UNet model for kidney tumour segmentation further can improve its efficacy and deployment feasibility. Related Works: Previous works have explored various techniques to improve the efficiency of deep learning models in medical image segmentation. Image partitioning methods divides the input image into smaller regions, enabling parallel processing and reducing memory requirements. Pruning techniques eliminates redundant or insignificant weights, neurons and connections, resulting in a more compact and efficient model architecture. However, the UNet model architecture and its complexity in the context of kidney tumor segmentation using UNet remains unexplored. Methodology: The proposed methodology consists of adaptive partitioning and weight pruning. Adaptive partitioning divides the UNet model into smaller sub-models, facilitating parallel processing and accelerating inference without compromising segmentation accuracy. Weight pruning techniques remove redundant or less significant weights from the UNet-P model, reducing complexity and improving inference time by eliminating unnecessary computations. The adaptive partitioning and weight pruning processes are seamlessly integrated within the UNet-P architecture, resulting in an optimized model for kidney tumor segmentation. Results: We performed experiments utilising a dataset of KiT 23 CT scan images containing images of kidney malignancies. Compared to the standard UNet model, the optimised UNet-PWP model with adaptive partitioning and weight pruning obtained significant efficiency gains. The adaptive partitioning permitted parallel computation of sub-models, which accelerated inference times. Weight pruning decreased the UNet-PWP model’s complexity without compromising segmentation accuracy, thereby enhancing efficiency. The results of our experiments demonstrated the efficacy of the proposed method with 98% accuracy, demonstrating its potential for deployment in health sector.

Preprint ARTICLE | doi:10.20944/preprints202110.0196.v1

Folic Acid Decorated β-Cyclodextrin-Based Poly(ε-Caprolactone)/Dextran Star Polymer with Disulﬁde Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy

Huikang Yang, Nianhua Wang, Ruimeng Yang, Li-Ming Zhang, Xinqing Jiang

Subject: Chemistry And Materials Science, Biomaterials Keywords: star polymer; β-cyclodextrin; tumor-targeted; disulﬁde bond; theranostic nanoparticles

Online: 13 October 2021 (11:00:40 CEST)

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Working Paper ARTICLE

Promoter Hypermethylation of Tumor Suppressor Genes, p16^INK4a, RASSF1A, TIMP3 and PCQAP/MED15, in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers

Chamikara Liyanage, Asanga Wathupola, Sanjayan Muraleetharan, Kanthi Perera, Chamindie Punyadeera, Preethi Udagama

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oral cancer; Oropharyngeal cancer; Tumor-suppressor genes; Promoter hypermethylation

Online: 19 March 2019 (12:56:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0868.v1

Dynamic survival risk prognostic model and Genomic Landscape for Atypical teratoid/rhabdoid tumor: A Population-Based, Real-World Study

Sihao Chen, Yi He, Jiao Liu, Ruixin Wu, Menglei Wang, Aishun Jin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Atypical teratoid/rhabdoid tumor; LASSO; Random Forest; SEER; COSMIC; Risk prognostic model, Genomic Landscape.

Online: 11 January 2024 (10:12:27 CET)

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Background: Atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon and aggressive pediatric central nervous system neoplasm. However, a universal clinical consensus or reliable prognostic evaluation system for this malignancy is lacking. Our study aimed to develop a risk model based on comprehensive clinical data to assist in clinical decision-making. Methods: We conducted a retrospective study by examining data from the Surveillance, Epidemiology, and End Results (SEER) repository, spanning 2000 to 2019. The external validation cohort was sourced from the Children's Hospital Affiliated to Chongqing Medical University, China. To discern independent factors affecting overall survival (OS) and cancer-specific survival (CSS), we applied Least Absolute Shrinkage and Selection Operator (LASSO) and Random Forest (RF) regression analyses. Based on these factors, we structured nomogram survival predictions and initiated a dynamic online risk-evaluation system. To contrast survival outcomes among diverse treatments, we used propensity score matching (PSM) methodology. Molecular data with the most common mutations in AT/RT were extracted from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. Results: The annual incidence of AT/RT showed an increasing trend (APC, 2.86%; 95% CI:0.75-5.01). Our prognostic study included 316 SEER database participants and 27 external validation patients. The entire group had a median OS of 18 months (range 11.5 to 24 months) and median CSS of 21 months (range 11.7 to 29.2). Evaluations involving C-statistics, DCA, and ROC analysis underscored the distinctive capabilities of our prediction model. An analysis via PSM highlighted that individuals undergoing triple therapy (integrating surgery, radiotherapy, and chemotherapy) had discernibly enhanced OS and CSS. The most common mutations of AT/RT identified in the COSMIC database were SMARCB1, BRAF, SMARCA4, NF2, and NRAS. Conclusions: In this study, we devised a predictive model that effectively gauges the prognosis of AT/RT and briefly analyzed its genomic features, which might offer a valuable tool to address existing clinical challenges.

Preprint REVIEW | doi:10.20944/preprints202404.1322.v1

Changing the Landscape of Solid Tumor Therapy From Apoptosis-Promoting to Apoptosis-Inhibiting Strategies

Razmik Mirzayans

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: solid tumor therapy; intratumor heterogeneity; polyploid giant cancer cells; senescence; anastasis; oncogenic caspases; Phoenix Rising; treacherous apoptosis; preclinical assays; precision oncology

Online: 22 April 2024 (08:33:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0421.v1

Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model

Julianne D. Twomey, Baolin Zhang

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: circulating tumor cells; CTCs; breast cancer; metastasis; death receptor; TRAIL; apoptosis; in vitro model

Online: 19 November 2018 (06:44:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0622.v1

Circulating Tumor Cell Separation of Blood Cells and Sorting in novel Microfluidic approaches: a review

Alireza Farahinia, W.J. Zhang, Ildiko Badea

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancerous Cell, Tumors, Cancer Metastasis, Circulating Tumor Cells (CTCs), Microfluidic Devices, lab-On-a-Chip (LOC), Lab-On-a-CD (LOCD)

Online: 29 October 2020 (15:38:54 CET)

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Separation and interpretation of rebellious Circulating Tumor Cells (CTCs) originating from the primary tumor or cancer tissue plays a significant role in diagnostics, cancer progression analyses, suitable medicine exploration, and treatment proficiency examination. Cancer metastasis occurs when CTCs spread throughout the body and invade healthy tissues, leading to new tumors in that area. Although a dramatic rate of deaths begins from spreading CTCs around the body, valuable measures have been made to control their development. However, the first step is separating these harmful cells from the bloodstream and investigating their features. Having examined the characteristics of CTCs as cancer’s main strength, researchers can introduce complementary treatments that can affect cancerous cells without damaging the healthy cells. Therefore, according to their unique characteristics, numerous techniques have been established for continuous and fast separation and sorting of CTCs. Nevertheless, few separators enjoy the efficient performance and appropriate accuracy and can be produced in mass numbers due to the available fabrication equipment. Microfabrication advancements enable separators to combine the advantages of active and passive methods in a small-scale platform for probing individual cells and separation purposes. Reduction in reagents, sample volume, analysis time, and less harmfulness to patients are some of the motivations that encourage researchers to employ microfluidic instruments for CTCs separation from other blood cells over the last two decades. However, microfabrication limitations mean effective separators, and the diagnostic option they provide, are not readily available. Addressing these limitations requires optimizing the design and fabrication of separators such that they are reduced in their size and fabrication cost, while also maintaining high-throughput separating capability. The emergence of the Lab-On-a-Chip (LOC) and then Lab-On-a-CD (LOCD) technologies, having more inherent benefits than conventional microfluidic devices, has created new opportunities and become increasingly widespread in recent years. Evidence suggests that employing single methodologies or integrating approaches without sufficient understanding of potential outcomes is unlikely to result in successful diagnostic results. This paper contributes an extensive review of several separation systems, including fundamental theories and experimental details, and describes detailed operating principles and device performance.

Preprint ARTICLE | doi:10.20944/preprints202107.0676.v1

Ultrasound Measurement of Tumor-Free Distance from the Serosal Surface as the Alternative to Measuring the Depth of Myometrial Invasion in Predicting Lymph Node Metastases in Endometrial Cancer

Marcin Liro, Marcin Śniadecki, Ewa Wycinka, Szymon Wojtylak, Michał Brzeziński, Agata Stańczak, Dariusz Grzegorz Wydra

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ultrasound; endometrial cancer; lymph nodes metastasis; myometrial invasion; tumor-free distance

Online: 30 July 2021 (09:06:16 CEST)

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Background: Ultrasonography’s usefulness in endometrial cancer (EC) diagnosis consists of its staging and predictive roles. Ultrasound-measured tumor-free distance from the tumor to the uterine serosa (uTFD) is a promising marker for this variable. The aim of the study was to determine the usefulness of this biomarker in locoregional staging, and thus in the prediction of lymph node metastasis (LNM). Methods: We conducted a single-institutional, prospective study on 116 consecutive patients with EC who underwent 2D transvaginal ultrasound examination. The uTFD marker was compared with the depth of ultrasound-measured myometrial invasion (uMI). Univariate and multivariate logit models were evaluated to assess the predictive power of the uTFD and uMI in regard to LNM. The reference standard was a final histopathology result. Survival was assessed by the Kaplan-Meyer method. Results: LNM was found in 17% of the patients (20/116). In the univariate analysis, uMI and uTFD were significant predictors of LNM. Accuracy was 70.7%, and NPV was 92.68% (OR 4.746, 95% CI 1.710-13.174) for uMI (p = 0.002), and 63.8%, and 89.02% (OR 0.842, 95% CI 0.736 – 0.963), respectively, for uTFD (p = 0.01). The cut-off value for uTFD in the prediction of LNM was 5.2 mm. The absence of LNM was associated more with biomarker values uMI <1/2 and uTFD >=5.2 mm than with the presence of metastases with uMI >1/2 and uTFD values <5.2 mm. In the multivariate analysis, the accuracy of the uMI-uTFD model was 74%, and NPV was 90.24% (p = NS). Neither uMI nor uTFD are surrogates for overall and recurrence-free survivals in endometrial cancer. Conclusions: Both uMI and uTFD, either alone or in combination, are valuable tools for gaining additional preoperative information on expected lymph node status. Negative lymph nodes status is better described by ultrasound biomarkers than a positive status. It is easier to use uTFD measurement as a biomarker of EC invasion than uMI, and the former still maintains a similar predictive value for lymph node metastases to the latter at diagnosis.

Preprint ARTICLE | doi:10.20944/preprints202205.0101.v1

Evaluation of Tumor Grade and Proliferation Indices before and after Short-Course Anti-Inflammatory Prednisone Therapy in Canine Cutaneous Mast Cell Tumors

Shawna Klahn, Nikolaos Dervisis, Kevin Lahmers, Marian Benitez

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: mast cell tumor; dog; canine; proliferation indices; grade; prednisone; Ki67; AgNOR; mitotic count; mitotic index

Online: 9 May 2022 (05:22:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0133.v1

Tumor-Specific Targeting of Polymer Drug Delivery Systems with Recombinant Proteins Bound via Tris(Nitrilotriacetic Acid)

Michal Pechar, Vlastimil Král, Lucie Woldřichová, Ladislav Androvič, Eliška Hrdá, Robert Pola, Sára Pytlíková, Martin Studenovský, Libor Kostka, Vladimír Šubr, Tomáš Etrych, Olga Kočková, Jéssica Mariane Ferreira Mendes, Milan Fábry, Richard Laga

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Hydrophilic polymers; Thermo-responsive polymers; Polymer drug delivery system; Tumor-specific targeting; Recombinant proteins; Non-covalent attachment; Tris(nitrilotriacetic acid) ligation

Online: 4 July 2023 (08:01:27 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1362.v1

Prechemotherapy Transperitoneal Robotic‐Assisted Partial Nephrectomy (RAPN) for a Wilms Tumor: Surgical and Oncological Outcomes in a Four‐Years‐Old Patient

Marcello Della Corte, Elisa Cerchia, Marco Oderda, Paola Quarello, Franca Fagioli, Paolo Gontero, Simona Gerocarni Nappo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Wilms Tumor; nephron‐sparing surgery; robotic surgery; partial nephrectomy; 3D reconstruction; DaVinci; metaverse; 3D virtual models

Online: 20 September 2023 (05:02:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0336.v1

Detection and Negative Reversion of Circulating Tumor Cells as Prognostic Biomarkers for Metastatic Castration-Resistant Prostate Cancer with Bone Metastases Treated by Enzalutamide

So Nakamura, Masayoshi Nagata, Naoya Nagaya, Takeshi Ashizawa, Hisashi Hirano, Yan Lu, Hisamitsu Ide, Shigeo Horie

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: circulating tumor cells (CTCs); enzalutamide; bone metastases; castration-resistant prostate cancer; androgen receptor signaling inhibitor

Online: 4 January 2024 (11:29:18 CET)

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Working Paper ARTICLE

Comparison of BSGI and MRI as Approaches to Evaluating Residual Tumor Status After Neoadjuvant Chemotherapy in Chinese Women With Breast Cancer

Hongbiao Liu, Hongwei Zhan, Ying Zhang, Gangqiang He, Hui Wang, Qiaoxia Zhang, Lili Zheng

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: breast-specific gamma imaging (BSGI); neoadjuvant chemotherapy (NAC); breast cancer; Magnetic resonance imaging (MRI); residual tumor size

Online: 6 July 2021 (12:40:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0046.v1

A Novel Network Science and Similarity Searching-Based Approach for Discovering Potential Tumor Homing Peptides from Antimicrobials

Maylin Romero, Yovani Marrero-Ponce, Hortensia Rodríguez, Guillermin Agüero-Chapin, Agostinho Antunes, Longendri Aguilera-Mendoza, Felix Martinez-Rios

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Cancer; tumor homing peptide; in silico drug discovery; complex network; chemical space network; centrality measure; similarity searching, group fusion; motif discovery; starPep toolbox software

Online: 3 February 2022 (10:14:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0380.v1

Circulating Tumor Cell Assay to Non-Invasively Evaluate PD-L1 and Other Therapeutic Targets in Multiple Cancers

Raymond Page, Darshana Patil, Dadasaheb Akolkar, Sudha S Murthy, Kiran Bendale, Revati Patil, Pradeep Fulmali, Pooja Fulmali, Archana Adhav, Sneha Puranik, Sachin Apurwa, Vineet Datta, Chirantan Bose, Stefan Schuster, Jinumary John, Ajay Srinivasan, Rajan Datar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Therapeutic biomarkers; circulating tumor cells; Immunocytochemistry; targeted therapy; Fluorescence in situ hybridization (FISH); Immune Checkpoint Inhibitors; Liquid Biopsy; Hormonal Treatments; Breast Cancer; Lung Cancer

Online: 25 January 2022 (11:31:05 CET)

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Working Paper ARTICLE

A Hybrid Ensemble Method for Accurate Breast Cancer Tumor Classification using State-of-the-Art Classification Learning Algorithms

Adel Saad Assiri, Sergio Velastin, Saima Nazir

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer tumor; classification; majority-based voting mechanism; multilayer perceptron learning network; simple logistic regression; stochastic gradient descent learning; wisconsin breast cancer dataset

Online: 27 November 2019 (09:51:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0328.v1

Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9

Hsi-Lung Hsieh, Ming-Chin Yu, Yu-Chia Chang, Yi-Hsuan Wu, Kuo-Hsiung Huang, Ming-Ming Tsai

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Lonicera japonica Thunb.; Matrix metallopeptidase-9; Tumor necrosis factor-α ; Cyclooxygenase-2

Online: 4 April 2024 (12:58:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0085.v1

Chick Embryo Experimental Platform for 3D Tissue Engineering Modelling of Cancer Micrometastases for Tumor Biology, Drug Development and Nanomaterials Testing

Anna Guller, Inga Kuschnerus, Vlada Rozova, Annemarie Nadort, Yin Yao, Zahra Khabir, Alfonso Garcia-Bennett, Liuen (Olivia) Liang, Aleksandra Polikarpova, Yi Qian, Ewa M. Goldys, Andrei Zvyagin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chick embryo; 3D culture; tumor models in vitro; tissue engineering; metastasis; triple-negative breast cancer; liver; mesoporous silica nanoparticles; doxorubicin; micrometastasis

Online: 6 September 2021 (11:46:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0312.v1

Decoding the Roles of Astrocytes and Hedgehog Signaling in Medulloblastoma

Terence Teixeira Duarte, Silvia Teixeira, Luis Gonzalez-Reyes, Rui Manuel Reis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: medulloblastoma; tumor progression; tumor microenvironment; tumor-associated astrocytes; hedgehog signaling; tumor-astrocytes cross talk

Online: 11 June 2021 (10:23:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0168.v1

New insights in Diffuse Large B Cell Lymphoma Pathobiology

Antonio Giovanni Solimando, Tiziana Annese, Roberto Tamma, Giuseppe Ingravallo, Eugenio Maiorano, Angelo Vacca, Giorgina Specchia, Domenico Ribatti

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: DLBCL; tumor microenvironment; angiogenesis; tumor progression

Online: 9 July 2020 (06:05:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1427.v1

Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic pathways to Promote Tumor Growth

Marilyn Mathew, Nhi Nguyen, Yangzom Bhutia, Sathish Sivaprakasam, Vadivel Ganapathy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: oncogenes; aerobic glycolysis; lactate receptors; nutrient transporters; glutamine addiction; one-carbon metabolism; glutaminolysis; reductive carboxylation; oncometabolites; tumor microenvironment

Online: 19 December 2023 (14:08:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.2038.v1

Harnessing Mechanical Forces for Cancer Treatment

Alka Kumari, S. Manasa Veena, Rashmita Luha, Ajay Tijore

Subject: Biology And Life Sciences, Life Sciences Keywords: mechanical force; apoptosis; tumor; tumor microenvironment; mechanomedicine

Online: 31 July 2023 (11:36:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1401.v1

NF-κB: Governing Innate Immunity in Cancer

Jessica Cornice, Daniela Verzella, Paola Arboretto, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Guido Franzoso

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: NF-κB; Tumor-associated macrophages (TAMs); Tumor microenvironment (TME)

Online: 18 January 2024 (14:05:44 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0146.v1

Recurrent Pheochromocytoma in an Elderly Patient

Ammu Susheela, Howide Eldib, Deepthi Vinnakota, Andrea Bial, Salman Ali, Hannah Koh, Brian Lavery, Martin Gorbien

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pheochromocytoma; neuroendocrine tumor

Online: 12 June 2020 (09:17:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0007.v1

Oncolytic Viruses for Malignant Glioma: On the Verge of Success?

Yogesh R. Suryawanshi, Autumn J Schulze

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Glioblastoma; Oncolytic Virus; Blood Brain Barrier; Tumor Microenvironment; Tumor Heterogeneity

Online: 3 May 2021 (11:01:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0277.v1

Epidemiology, Clinical Manifestations, and Management of Prolactinomas: A Comprehensive Study

Nikolaos Mavritsakis, Răzvan Mihai Șușan, Monica Maria Șușan, Gogean Gina Groza, Vasile Emil Ursu, Răzvan Gheorghe Rusu, Dan Boariu, Elena Ionescu, Raul Ioan Muntean, Cristina Maria Man

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: pituitary tumor; hyperprolactinemia; amenorrhea

Online: 5 February 2024 (15:33:23 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202309.0052.v1

Giant Hepatic Hemangioma, a Case Report. When Hepatic Resection Is Not Enough

Carmen Acosta Gallardo, Natalia Zambudio Carrol, Alejandro José Pérez Alonso, Esther Brea Gómez, María Trinidad Villegas Herrera, Jesús María Villar del Moral

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: liver transplant; tumor liver

Online: 1 September 2023 (10:01:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0766.v1

Mathematical Modeling of Non-small Cell Lung Cancer Biology Through the Experimental Data on Cell Composition and Growth of Patient-Derived Organoids

Rushan A. Sulimanov, Konstantin B. Koshelev, Vladimir A. Makarov, Alexander V. Mezentsev, Mikhail O. Durymanov, Komal Zahid, Lilian Ismail, Yegor Y. Rumyantsev, Ilya A. Laskov

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mathematical modeling; non-small cell lung cancer; tumor microenvironment; patient-derived tumor organoids

Online: 12 October 2023 (05:05:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0503.v1

PCa-Clf: A Classifier of Prostate Cancer Patients into Indolent and Aggressive Using Machine Learning

Yashwanth Karthik Kumar Mamidi, Tarun Karthik Kumar Mamidi, Md Wasi Ul Kabir, Jiande Wu, Md Tamjidul Hoque, Chindo Hicks

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine learning; stacking; prostate cancer; indolent tumor; aggressive tumor; gleason grade; ml-classifiers

Online: 7 July 2023 (15:35:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0286.v1

Interleukin 17 and Its Involvement in Renal Cell Carcinoma

Michał Jarocki, Julia Karska, Szymon Kowalski, Paweł Kiełb, Łukasz Nowak, Wojciech Krajewski, Jolanta Saczko, Julita Kulbacka, Tomasz Szydełko, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: interleukin-17; renal cell carcinoma; immunotherapy; inflammation; tumor microenviroment; tumor development; Th17 lymphocytes

Online: 21 June 2022 (05:11:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0386.v1

Meta-Analysis of Microdissected Breast Tumors Reveals Genes Regulated in the Stroma but Hidden in Bulk Analysis

Aurora Savino, Niccolò de Marzo, Paolo Provero, Valeria Poli

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tumor microenvironment; meta-analysis; tumor stroma; breast cancer; LCM; microdissection; transcriptomics; microarray; database

Online: 17 May 2021 (13:17:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0265.v1

Biofilm and Cancer: Interactions and Future Direction for Cancer Therapy

Euna Choi, Ben Murray, Sunga Choi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: extracellular polymeric substance (EPS); tumor microenvironment (TME); tumor microbiome (TM); tumor-associated macrophages (TAM); colorectal cancer (CRC); Fusobacterium nucleatum (Fn); Helicobacter py

Online: 3 August 2023 (10:47:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0337.v1

The Role of Tnf and Soluble Tnf Receptors (TNFR1/2) as Therapeutic Targets for Inflammation Secondary to Intracerebral Stroke and Hemorrhage

Rakan Alshaibi, Kanishka Ekanayake, Emily Barlow, Ali Ahmed Mohamed, Brandon Lucke-Wold

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebroprotection; ischemia; tumor necrosis factor

Online: 4 April 2024 (06:04:04 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0752.v1

Ovarian Fibrothecoma in a Mare-Case Report

Raimonda Tamulionytė-Skėrė, Nomeda Juodžiukynienė, Paulina Rimkutė, Renata Gruodytė, Iveta Duliebaitė, Akvilė Savickytė

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: thecoma; ovarian tumor; neoplasia; histopathology

Online: 13 March 2024 (07:24:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1524.v1

Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis

Lorena Cayetano-Salazar, Adán Arizmendi-Izazaga, Dania A. Nava-Tapia, Eymard Hernández-López, Caroline Weinstein-Oppenheimer, Julio Ortiz-Ortiz, Marco A. Leyva-Vázquez, Miguel A. Mendoza-Catalán, Napoleón Navarro-Tito

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; TIMPs; tumor progression

Online: 21 June 2023 (10:16:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0015.v1

A New Venue of TNF Targeting

Sophie Steeland, Claude Libert, Roosmarijn E. Vandenbroucke

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: tumor necrosis factor; TNFR; biologicals

Online: 2 April 2018 (09:43:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0632.v1

Enhancing Breast Cancer Therapy: Nanocarrier-Based Targeted Drug Delivery

Ramendra Pandey, Ruby Dhiman, Nancy Bazad, Riya Mukerjee, Jasmina Vidic, Elcio Leal, V. Samuel Raj, Chung-Ming Chang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Breast cancer; Nanocarriers; Tumor location; Diagnostics

Online: 9 December 2023 (08:19:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0315.v1

Cellular and Molecular Mechanisms Implicated in the Dual Role of ROR2 in Cancer

Maria Victoria Castro, Pablo Lopez-Bergami

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ROR2; cancer; oncogene; tumor-suppressor gene.

Online: 17 November 2021 (23:39:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0116.v1

Study on the Value of C1q in the Diagnosis of Esophageal Cancer

Xin Cai, Huan Li, Juanjuan Chen, Dongling Tang, Pingan Zhang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: C1q; Biomarker; Esophageal cancer; Diagnosis; Tumor

Online: 7 September 2021 (10:03:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0088.v1

Skeletal Metastases of Unknown Primary: Biological Landscape and Clinical Overview

Antonella Argentiero, Antonio Giovanni Solimando, Oronzo Brunetti, Angela Calabrese, Francesco Pantano, Michele Iuliani, Daniele Santini, Nicola Silvestris, Angelo Vacca

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: skeletal metastases of unknown primary; SMUP; bone metastases; unknown primary tumor; bisphosphonates; bone markers; tumor microenvironment

Online: 7 August 2019 (03:57:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1165.v1

Improving Generalizability of PET DL Algorithms: List-Mode Reconstructions Improve DOTATATE PET Hepatic Lesion Detection Performance

Xinyi Yang, Michael Silosky, Jonathan Wehrend, Daniel V Litwiller, Muthiah Nachiappan, Scott D Metzler, Debashis Ghosh, Fuyong Xing, Bennett B Chin

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Deep learning; Convolutional neural network; Gastroenteropancreatic neuroendocrine tumor; GEP-NET; DOTATATE; Positron emission tomography; PET; Liver tumor.

Online: 20 February 2024 (15:38:44 CET)

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Deep learning (DL) algorithms used for DOTATATE PET lesion detection typically require large, well-annotated training datasets. These are difficult to obtain due to low incidence of gastroenteopancreatic neuroendocrine tumors (GEP-NETs), and the high cost of manual annotation. Furthermore, networks trained and tested with data acquired from site specific PET/CT instrumentation, acquisition and processing protocols have reduced performance when tested with offsite data. This lack of generalizability requires even larger, more diverse training datasets. The objective of this study is to investigate the feasibility of improving DL algorithm performance by better matching the background noise in training datasets to higher noise, out-of-domain testing datasets. 68Ga-DOTATATE PET/CT datasets were obtained from two scanners: Scanner1, a state-of-the-art digital PET/CT (GE DMI PET/CT; n=83 subjects), and Scanner2, an older-generation analog PET/CT (GE STE; n=123 subjects). Set1, the data set from Scanner1 was reconstructed with standard clinical parameters (5 minutes; Q.Clear) and list-mode reconstructions (VPFXS 2, 3, 4, and 5-minutes). Set2, data from Scanner2, representing out-of-domain clinical scans, used standard iterative reconstruction (5 minutes; OSEM). Reconstructed datasets were divided into training, validation, and testing datasets in a 60%, 20%, 20% proportion, and a deep neural network was trained with each: Network1 for Scanner1 and Network2 for Scanner2. DL performance (Network1) was tested with out-of-domain test data (Set2). To evaluate the effect of training sample size, we tested DL model performance using a fraction (25%, 50%, and 75%) of Set1 for training. Scanner1, list-mode 2-minute reconstructed data demonstrated the most similar noise level compared that of Set2, resulting in the best performance (F1=0.713). This was not significantly different compared to the highest performance, upper-bound limit using in-domain training for Network2 (F1=0.755; p-value=0.103). Regarding sample size, the F1 score significantly increased from 25% training data (F1=0.478) to 100% training data (F1=0.713; p<0.001). List-mode data from modern PET scanners can be reconstructed to better match the noise properties of older scanners. Using existing data and their associated annotations dramatically reduces the cost and effort in generating these datasets, and significantly improves the performance of existing DL algorithms. List-mode reconstructions can provide an efficient, low-cost method to improve DL algorithm generalizability.

Preprint ARTICLE | doi:10.20944/preprints202404.1550.v1

Non-syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors (eGCT): Data of 2,610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population

Judit Schultewolter, Anke K. Rißmann, Dietrich Von Schweinitz, Michael Frühwald, Claudia Blattmann, Lars Fischer, Bjoern Soenke Lange, Rüdiger Wessalowski, Birgit Fröhlich, Wolfgang Behnisch, Irene Schmid, Harald Reinhard, Matthias Duerken, Patrick Hundsdoerfer, Martin Heimbrodt, Christian Vokuhl, Stefan Schönberger, Dominik T. Schneider, Guido Seitz, Ulrich Göbel, Rüdiger Von Kries, Heiko M. Reutter, Gabriele Calaminus

Subject: Pediatrics, Perinatology And Child Health, Medicine And Pharmacology Keywords: germ cell tumor; syndrome; non-syndromic defect

Online: 23 April 2024 (16:59:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1099.v1

Dendritic Cells Immunotherapy of Ovarian Cancer: Overview of Our Achievements

Jiřina Bartůňková

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ovarian cancer; dendritic cells; immunotherapy; tumor microenvironment

Online: 20 February 2024 (07:05:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1307.v1

Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry

Giovanna L. Liguori

Subject: Biology And Life Sciences, Life Sciences Keywords: glioblastoma; extracellular vesicles; tumor therapy; drug-delivery

Online: 18 December 2023 (13:36:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0767.v1

CD147/Basigin Is Involved in the Development of Malignant Tumors and T Cell Mediated Immunological Disorders via Regulation of Glycolysis

Takuro Kanekura

Subject: Medicine And Pharmacology, Dermatology Keywords: CD147; glycolysis; malignant tumor; psoriasis; immune disorder

Online: 13 November 2023 (08:39:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0847.v1

MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential

Junjiang Fu, Saber Imani, Mei-Yi Wu, Ray-Chang Wu

Subject: Biology And Life Sciences, Life Sciences Keywords: microRNA; miR‐34; tumor suppressor; miRNA therapy

Online: 10 August 2023 (10:53:25 CEST)

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