Version 1
: Received: 27 July 2023 / Approved: 28 July 2023 / Online: 31 July 2023 (11:36:26 CEST)
How to cite:
Kumari, A.; Veena, S.M.; Luha, R.; Tijore, A. Harnessing Mechanical Forces for Cancer Treatment. Preprints2023, 2023072038. https://doi.org/10.20944/preprints202307.2038.v1
Kumari, A.; Veena, S.M.; Luha, R.; Tijore, A. Harnessing Mechanical Forces for Cancer Treatment. Preprints 2023, 2023072038. https://doi.org/10.20944/preprints202307.2038.v1
Kumari, A.; Veena, S.M.; Luha, R.; Tijore, A. Harnessing Mechanical Forces for Cancer Treatment. Preprints2023, 2023072038. https://doi.org/10.20944/preprints202307.2038.v1
APA Style
Kumari, A., Veena, S.M., Luha, R., & Tijore, A. (2023). Harnessing Mechanical Forces for Cancer Treatment. Preprints. https://doi.org/10.20944/preprints202307.2038.v1
Chicago/Turabian Style
Kumari, A., Rashmita Luha and Ajay Tijore. 2023 "Harnessing Mechanical Forces for Cancer Treatment" Preprints. https://doi.org/10.20944/preprints202307.2038.v1
Abstract
Cancer cells exhibit aberrant extracellular matrix mechanosensing due to altered expression of mechanosensory cytoskeletal proteins. Aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells has been shown to be associated with cancer development and progression. Recent studies show that altered mechanosensing changes the mechanobiological properties of cells, and, in turn, cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this review, we summarize the progress that happened in the development of mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
