Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis

Lorena Cayetano-Salazar; Adán Arizmendi-Izazaga; Dania A. Nava-Tapia; Eymard Hernández-López; Caroline Weinstein-Oppenheimer; Julio Ortiz-Ortiz; Marco A. Leyva-Vázquez; Miguel A. Mendoza-Catalán; Napoleón Navarro-Tito

doi:10.20944/preprints202306.1524.v1

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202306.1524.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis

Lorena Cayetano-Salazar

Adán Arizmendi-Izazaga

Dania A. Nava-Tapia

Eymard Hernández-López

Caroline Weinstein-Oppenheimer

Julio Ortiz-Ortiz

Marco A. Leyva-Vázquez

Miguel A. Mendoza-Catalán

Napoleón Navarro-Tito

Version 1 : Received: 20 June 2023 / Approved: 21 June 2023 / Online: 21 June 2023 (10:16:51 CEST)

How to cite: Cayetano-Salazar, L.; Arizmendi-Izazaga, A.; Nava-Tapia, D.A.; Hernández-López, E.; Weinstein-Oppenheimer, C.; Ortiz-Ortiz, J.; Leyva-Vázquez, M.A.; Mendoza-Catalán, M.A.; Navarro-Tito, N. Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis. Preprints 2023, 2023061524. https://doi.org/10.20944/preprints202306.1524.v1 Cayetano-Salazar, L.; Arizmendi-Izazaga, A.; Nava-Tapia, D.A.; Hernández-López, E.; Weinstein-Oppenheimer, C.; Ortiz-Ortiz, J.; Leyva-Vázquez, M.A.; Mendoza-Catalán, M.A.; Navarro-Tito, N. Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis. Preprints 2023, 2023061524. https://doi.org/10.20944/preprints202306.1524.v1

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MDPI and ACS Style

Cayetano-Salazar, L.; Arizmendi-Izazaga, A.; Nava-Tapia, D.A.; Hernández-López, E.; Weinstein-Oppenheimer, C.; Ortiz-Ortiz, J.; Leyva-Vázquez, M.A.; Mendoza-Catalán, M.A.; Navarro-Tito, N. Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis. Preprints 2023, 2023061524. https://doi.org/10.20944/preprints202306.1524.v1

APA Style

Cayetano-Salazar, L., Arizmendi-Izazaga, A., Nava-Tapia, D.A., Hernández-López, E., Weinstein-Oppenheimer, C., Ortiz-Ortiz, J., Leyva-Vázquez, M.A., Mendoza-Catalán, M.A., & Navarro-Tito, N. (2023). Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis. Preprints. https://doi.org/10.20944/preprints202306.1524.v1

Chicago/Turabian Style

Cayetano-Salazar, L., Miguel A. Mendoza-Catalán and Napoleón Navarro-Tito. 2023 "Biological and Clinical Significance of TIMPs Expression in Breast Cancer: a Bioinformatic Analysis" Preprints. https://doi.org/10.20944/preprints202306.1524.v1

Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are essential players during tumor progression in various types of cancer, including breast cancer. TIMPs regulate the activity of matrix metallo-proteinases (MMPs) at different levels. However, a dual role for TIMPs in breast carcinogenesis, either promoting or inhibiting tumor progression, has been observed. By a comprehensive bioin-formatics analysis using different databases, we report that of the four TIMPs, only TIMP-1 is overexpressed in tumor breast tissue. However, TIMP-2, TIMP-3, and especially TIMP-4 present lower levels in breast tumor tissue than in normal tissue. Interestingly, high levels of TIMP-1 are associated with shorter survival in breast cancer patients. In contrast, low TIMP-2, TIMP-3, and TIMP-4 levels are associated with poor survival. Function enrichment analysis showed that TIMP-3 has the highest interactions with its target proteins and a higher number of processes re-lated to mammary carcinogenesis. We found differential expression of TIMP-1 concerning TIMP-3 and TIMP-4 in breast cancer and normal tissue. TIMP-4 has a significant relationship with cancer staging, including tumor size, lymph node spread, and metastasis. The correlation between immune cell infiltrates and TIMP expression is of great importance as they provide in-formation on breast cancer diagnosis, prognosis, progression, and response to treatment.

Keywords

breast cancer; TIMPs; tumor progression

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 18 September 2023
Commenter:

Tania Bahamondez-Canas

The commenter has declared there is no conflict of interests.

Comment: Great article fo using on a the relevance on TIMPs. I have worked with TIMPs and the role of their unbalance in wound healing. So I found very interesting this new role that TIMPs may habe in cancer.

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