Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumor for Approaching the Novel Research Animal Model

Version 1 : Received: 28 February 2024 / Approved: 28 February 2024 / Online: 28 February 2024 (09:50:07 CET)

A peer-reviewed article of this Preprint also exists.

Min, T.; Lee, S.-H.; Lee, S. Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumors. Animals 2024, 14, 1118. Min, T.; Lee, S.-H.; Lee, S. Angiogenesis and Apoptosis: Data Comparison of Similar Microenvironments in the Corpus Luteum and Tumors. Animals 2024, 14, 1118.

Abstract

The corpus luteum is a temporary endocrine gland formed in the ovary after ovulation, and it plays a critical role in reproductive processes. Tumors rely on the development of an adequate blood supply to ensure the delivery of nutrients and oxygen and the removal of waste products. While angiogenesis occurs in various physiological and pathological contexts, the corpus luteum and tumors share similarities in the signaling pathways that promote angiogenesis. In the corpus luteum and tumors, apoptosis plays a crucial role in controlling cell numbers and ensuring proper tissue development and function. Interestingly, there are similarities in the apoptotic-regulated signaling pathways involved in apoptosis between the corpus luteum and tumors. However, the regulation of apoptosis can differ due to their distinct physiological and pathological characteristics. Thus, we reviewed the biological events of the corpus luteum and tumors in similar microenvironments of angiogenesis and apoptosis for studying novel research methods.

Keywords

ovary; corpus luteum; tumor; angiogenesis; apoptosis

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

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