Fu, J.; Imani, S.; Wu, M.-Y.; Wu, R.-C. MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential. Cancers2023, 15, 4723.
Fu, J.; Imani, S.; Wu, M.-Y.; Wu, R.-C. MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential. Cancers 2023, 15, 4723.
Fu, J.; Imani, S.; Wu, M.-Y.; Wu, R.-C. MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential. Cancers2023, 15, 4723.
Fu, J.; Imani, S.; Wu, M.-Y.; Wu, R.-C. MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential. Cancers 2023, 15, 4723.
Abstract
MicroRNA (miRNA) is small non-coding RNAs that play vital roles in post-transcriptional gene regulation by inhibiting mRNA translation or promoting mRNA degradation. Dysregulation of miRNA has been implicated in numerous human diseases, including cancers. The family members of miR-34 (miR-34s), composed of miR-34a, miR-34b, and miR-34c, have emerged as the most extensively studied tumor-suppressive miRNAs. In this comprehensive review, we aim to provide an overview of the major signaling pathways and gene networks regulated by the miR-34s in various cancers and highlight the critical tumor suppressor role of miR-34s. Furthermore, we will discuss the potential of using miR-34 mimics as a novel therapeutic approach against cancer, while also addressing the challenges associated with their development and delivery. It is anticipated that gaining a deeper understanding of the functions and mechanisms of miR-34s in cancer will greatly contribute to the development of effective miR-34-based cancer therapeutics.
Keywords
microRNA; miR‐34; tumor suppressor; miRNA therapy
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
