Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products

Version 1 : Received: 25 July 2021 / Approved: 26 July 2021 / Online: 26 July 2021 (15:42:33 CEST)

How to cite: Liu, X.; Xu, H.; Feng, Y.; Hou, X. Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products. Preprints 2021, 2021070592 (doi: 10.20944/preprints202107.0592.v1). Liu, X.; Xu, H.; Feng, Y.; Hou, X. Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products. Preprints 2021, 2021070592 (doi: 10.20944/preprints202107.0592.v1).

Abstract

Mechanical properties of tumor cytoskeleton are extremely vital for any phases of cancer, especially in tumor invasion and metastasis. However, in current category of anticancer drugs, the cytoskeleton-targeting drugs are limited and its role in tumor progression is unclear. Here, we present the mechanical characteristics of tumor stiffness are tightly regulated by cancer cytoskeleton including actin filaments and microtubule during tumor initiation, growth and metastasis, and review the natural drugs that target cancer cytoskeleton. We define cytoskeleton dynamics as target mechanisms for anticancer drug, and summary the plant, microbial and marine sources of natural products. Furthermore, the material approaches to active cancer mechanics are supplied in this review. We aim to promote the development of anticancer drugs that target tumor mechanics by using those material approaches in future and find its pharmacological application.

Keywords

anticancer drugs; mechanical microenvironment; tumor stiffness; cytoskeleton dynamics; material approaches

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