Version 1
: Received: 25 July 2021 / Approved: 26 July 2021 / Online: 26 July 2021 (15:42:33 CEST)
How to cite:
Liu, X.; Xu, H.; Feng, Y.; Hou, X. Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products. Preprints2021, 2021070592. https://doi.org/10.20944/preprints202107.0592.v1
Liu, X.; Xu, H.; Feng, Y.; Hou, X. Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products. Preprints 2021, 2021070592. https://doi.org/10.20944/preprints202107.0592.v1
Liu, X.; Xu, H.; Feng, Y.; Hou, X. Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products. Preprints2021, 2021070592. https://doi.org/10.20944/preprints202107.0592.v1
APA Style
Liu, X., Xu, H., Feng, Y., & Hou, X. (2021). Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products. Preprints. https://doi.org/10.20944/preprints202107.0592.v1
Chicago/Turabian Style
Liu, X., Yuting Feng and Xiaolin Hou. 2021 "Development of Anticancer Drugs: From Mechanical Properties of Tumor Stiffness to Cytoskeleton-Targeting Natural Products" Preprints. https://doi.org/10.20944/preprints202107.0592.v1
Abstract
Mechanical properties of tumor cytoskeleton are extremely vital for any phases of cancer, especially in tumor invasion and metastasis. However, in current category of anticancer drugs, the cytoskeleton-targeting drugs are limited and its role in tumor progression is unclear. Here, we present the mechanical characteristics of tumor stiffness are tightly regulated by cancer cytoskeleton including actin filaments and microtubule during tumor initiation, growth and metastasis, and review the natural drugs that target cancer cytoskeleton. We define cytoskeleton dynamics as target mechanisms for anticancer drug, and summary the plant, microbial and marine sources of natural products. Furthermore, the material approaches to active cancer mechanics are supplied in this review. We aim to promote the development of anticancer drugs that target tumor mechanics by using those material approaches in future and find its pharmacological application.
Keywords
anticancer drugs; mechanical microenvironment; tumor stiffness; cytoskeleton dynamics; material approaches
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
