Version 1
: Received: 10 October 2023 / Approved: 10 October 2023 / Online: 10 October 2023 (08:31:28 CEST)
How to cite:
Itoh, K.; Shichijo, S.; Suekane, S. Sequence Similarity between Commensal Bifidobacterium and Cytotoxic T Lymphocyte Epitope Peptides against Human Tumor-Associated Antigens. Preprints2023, 2023100598. https://doi.org/10.20944/preprints202310.0598.v1
Itoh, K.; Shichijo, S.; Suekane, S. Sequence Similarity between Commensal Bifidobacterium and Cytotoxic T Lymphocyte Epitope Peptides against Human Tumor-Associated Antigens. Preprints 2023, 2023100598. https://doi.org/10.20944/preprints202310.0598.v1
Itoh, K.; Shichijo, S.; Suekane, S. Sequence Similarity between Commensal Bifidobacterium and Cytotoxic T Lymphocyte Epitope Peptides against Human Tumor-Associated Antigens. Preprints2023, 2023100598. https://doi.org/10.20944/preprints202310.0598.v1
APA Style
Itoh, K., Shichijo, S., & Suekane, S. (2023). Sequence Similarity between Commensal Bifidobacterium and Cytotoxic T Lymphocyte Epitope Peptides against Human Tumor-Associated Antigens. Preprints. https://doi.org/10.20944/preprints202310.0598.v1
Chicago/Turabian Style
Itoh, K., Shigeki Shichijo and Shigetaka Suekane. 2023 "Sequence Similarity between Commensal Bifidobacterium and Cytotoxic T Lymphocyte Epitope Peptides against Human Tumor-Associated Antigens" Preprints. https://doi.org/10.20944/preprints202310.0598.v1
Abstract
The precise molecular basis of anti-tumor immunity is not yet fully understood, although commensal Bifidobacterium (c-BIF) is expected to be one of the key players in cancer control via antigenic mimicry. We investigated the sequence similarity between c-BIF and cytotoxic T lymphocyte (CTL) epitope peptides against human tumor-associated antigens to better understand the molecular basis of antigenic mimicry. We used two different similarity analyses for this purpose, a linear sequence analysis and a similarity analysis of T cell receptor (TCR)-mediated recognition of CTL epitope peptides on antigen-presenting cells. The linear sequence analysis revealed 3,900 positive numbers of similarity sites between them with 126 mean per peptide and 107 median per peptide, while the TCR-mediated recognition analysis revealed 5,018 positive numbers with a mean of 162 and median of 132 per peptide. These results demonstrated the existence of durable and abundant sequence similarities between c-BIF and CTL epitope peptides, suggesting that the former play a pivotal in inducing cellular and humoral immunity against the latter in the absence of cancer cells via antigenic mimicry.
Keywords
anti-tumor immunity; antigenic mimicry; CTL epitope peptides; human tumor-associated antigens; intestinal microbiota; linear sequence analysis; TCR-mediated recognition analysis
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
