Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review

Version 1 : Received: 18 November 2021 / Approved: 19 November 2021 / Online: 19 November 2021 (14:28:29 CET)

How to cite: Peng, Z.; Lin, X.; Nian, W.; Zheng, X.; Wu, J. Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review. Preprints 2021, 2021110357 (doi: 10.20944/preprints202111.0357.v1). Peng, Z.; Lin, X.; Nian, W.; Zheng, X.; Wu, J. Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review. Preprints 2021, 2021110357 (doi: 10.20944/preprints202111.0357.v1).

Abstract

Early diagnosis and treatment have always been highly desired in the fight against cancer, and detection of circulating tumor DNA (ctDNA) has recently been touted as highly promising for early cancer screening. Consequently, the detection of ctDNA in liquid biopsy gains much attention in the field of tumor diagnosis and treatment, which has also attracted research interest from the industry. However, traditional gene detection technology is difficult to achieve low cost, real-time and portable measurement of ctDNA. Electroanalytical biosensors have many unique advantages such as high sensitivity, high specificity, low cost and good portability. Therefore, this review aims to discuss the latest development of biosensors for minimal-invasive, rapid, and real-time ctDNA detection. Various ctDNA sensors are reviewed with respect to their choices of receptor probes, detection strategies and figures of merit. Aiming at the portable, real-time and non-destructive characteristics of biosensors, we analyze their development in the Internet of Things, point-of-care testing, big data and big health.

Keywords

non-destructive; biosensors; real-time detection; circulating tumor DNA (ctDNA); high sensitivity; Internet of Things

Subject

ENGINEERING, Biomedical & Chemical Engineering

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.