Peng, Z.; Lin, X.; Nian, W.; Zheng, X.; Wu, J. Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review. Preprints2021, 2021110357. https://doi.org/10.20944/preprints202111.0357.v1
APA Style
Peng, Z., Lin, X., Nian, W., Zheng, X., & Wu, J. (2021). Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review. Preprints. https://doi.org/10.20944/preprints202111.0357.v1
Chicago/Turabian Style
Peng, Z., Xiaodong Zheng and Jayne Wu. 2021 "Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review" Preprints. https://doi.org/10.20944/preprints202111.0357.v1
Abstract
Early diagnosis and treatment have always been highly desired in the fight against cancer, and detection of circulating tumor DNA (ctDNA) has recently been touted as highly promising for early cancer screening. Consequently, the detection of ctDNA in liquid biopsy gains much attention in the field of tumor diagnosis and treatment, which has also attracted research interest from the industry. However, traditional gene detection technology is difficult to achieve low cost, real-time and portable measurement of ctDNA. Electroanalytical biosensors have many unique advantages such as high sensitivity, high specificity, low cost and good portability. Therefore, this review aims to discuss the latest development of biosensors for minimal-invasive, rapid, and real-time ctDNA detection. Various ctDNA sensors are reviewed with respect to their choices of receptor probes, detection strategies and figures of merit. Aiming at the portable, real-time and non-destructive characteristics of biosensors, we analyze their development in the Internet of Things, point-of-care testing, big data and big health.
Keywords
non-destructive; biosensors; real-time detection; circulating tumor DNA (ctDNA); high sensitivity; Internet of Things
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
