Electric and/or magnetic fields are generated by stationary charges, uniformly moving charges and accelerating charges. These field components are described in the literature as static fields, velocity fields (or generalized Coulomb field) and radiation fields (or acceleration fields), respectively. In the literature, the electromagnetic fields generated by lightning return strokes are presented using the field components associated with short dipoles and in this description the one to one association of the electromagnetic field terms with the physical process that gives rise to them is lost. In this paper, we will derive expressions for the electromagnetic fields using field equations associated with accelerating (and moving) charges and separate the resulting fields into static, velocity and radiation fields. The results illustrates how the radiation fields emanating from the lightning channel give rise to field terms varying as inverse of distance and distance squired, the velocity fields generating field terms varying as inverse of distance squired and the static fields generating fields components varying as inverse of distance squired and distance cube. These field components depend explicitly on the speed of propagation of the current pulse. However, the total field does not depend explicitly on the speed of propagation of the current pulse. It is shown that these field components can be combined to generate the field components pertinent to the dipole technique. However, in this conversion process the connection of the field components to the physical process taking place at the source that generate these fields (i.e. static charges, uniformly moving charges and accelerating charges) is lost.

The efficiency of microbial inactivation in water is highly dependent on the type of treatment technology used as well as the characteristics of the water to be treated. Wastewater from poultry slaughterhouses carries a significant number of microorganisms posing threat to humans and the environment in general. Therefore, the treatment of poultry slaughterhouse wastewater requires the use of appropriate purification systems with high removal efficiency for microbial agents. In this study, the performance of an integrated treatment plant with electrolysis, ultrafiltration, and ultraviolet radiation as the principal treatment units is investigated in terms of microbial inactivation from poultry slaughterhouse wastewater. In this case, Total microbial number, Total coliform bacteria, Thermo-tolerant coliform bacteria, Pathogenic flora, including Salmonella coliphages, Spores of sulfite-reducing clostridia, Pseudomonas aeruginosa, and Staphylococcus aureus Enterococcus were studied. About 63.95% to 99.83% of the microbes were removed by the EC treatment unit, as well as 99.86% to 100% removal efficiency was achieved after the combined treatment. However, the Pseudomonas aeruginosa was the only microbial agent detected in the final effluent after the combined treatment. The phenomenon suggests that an upgrade to the treatment plant may be required to achieve 100% removal assurance for Pseudomonas aeruginosa.

Hydrogenated amorphous silicon (a-Si:H) can be produced by plasma-enhanced chemical vapour deposition (PECVD) of SiH4 (Silane) mixed with Hydrogen. The resulting material shows outstanding radiation resistance properties and can be deposited on a wide variety of different substrates. These devices have been used to detect many different kinds of radiation namely: MIPs, x-rays, neutrons and ions as well as low energy protons and alphas. However, MIP detection using planar diodes has always been difficult due to the unsatisfactory S/N ratio arising from a combination of high leakage current, high capacitance and a limited charge collection efficiency (50% at best for a 30 µm planar diode). To overcome these limitations the 3D-SiAm collaboration proposes to use a 3D detector geometry. The use of vertical electrodes allows for a small collection distance to be maintained while conserving a large detector thickness for charge generation. The depletion voltage in this configuration can be kept below 400 V with consequent reduction in the leakage current. In this paper, following a detailed description of the fabrication process, the results of the tests performed on the planar p-i-n structures made with ion implantation of the dopants and with carrier selective contacts will be illustrated.

The efficiency of microbial inactivation in water is highly dependent on the type of treatment technology used as well as the characteristics of the water to be treated. Wastewater from poultry slaughterhouses carries a significant number of microorganisms posing threat to humans and the environment in general. Therefore, the treatment of poultry slaughterhouse wastewater requires the use of appropriate purification systems with high removal efficiency for microbial agents. In this study, the performance of an integrated treatment plant with electrolysis, ultrafiltration, and ultraviolet radiation as the principal treatment units is investigated in terms of microbial inactivation from poultry slaughterhouse wastewater. In this case, Total microbial number, Total coliform bacteria, Thermo-tolerant coliform bacteria, Pathogenic flora, including Salmonella coliphages, Spores of sulfite-reducing clostridia, Pseudomonas aeruginosa, and Staphylococcus aureus Enterococcus were studied. About 63.95% to 99.83% of the microbes were removed by the EC treatment unit, as well as 99.86% to 100% removal efficiency was achieved after the combined treatment. However, the Pseudomonas aeruginosa was the only microbial agent detected in the final effluent after the combined treatment. The phenomenon suggests that an upgrade to the treatment plant may be required to achieve 100% removal assurance for Pseudomonas aeruginosa.

A novel method of investigating the temperature dependent variation of aspects of the complex refractive index n* in samples in the THz range using continuous, non-polarised, synchrotron radiation is presented. The method relies on the use of ATR apparatus, and retains the advantage of minimal sample preparation, which is a feature of ATR techniques. The method demonstrates the viability of rapidly monitoring temperature reflectance whilst continuously heating or cooling samples by using a temperature variable Thermal Sample Stage. The method remains useful when the refractive index of the sample precludes attenuated total reflection study. This is demonstrated with the water reflectance experiments. The temperature dependent ATR reflectance of tissue-representative fats (lard and Lurpak® butter) was investigated with the novel approach. Both are within the ATR range of the diamond crystal in a “true” ATR mode. Lard showed no clear temperature variation between -15 0C and 24 0C at 0.7 to 1.15 THz or 1.70 to 2.25 THz. Lard can be regarded as having invariable, constant, dielectric properties within mixtures when biological substances are being assessed for temperature dependent dielectric variation within the stated THz ranges. Lurpak® butter (water content 14.7%) displayed temperature dependent reflectance features with a steady decline in reflectivity with increasing temperature. This is in line with the temperature-dependent behaviour of liquid water. There is no rapid change in reflectance, even at -20 0C, suggesting that emulsified water retains liquid-water-like THz properties at freezing temperatures.

Small RNAs are essential for the coordination of many cellular processes, including the regulation of gene expression patterns, the prevention of genomic instability, and the suppression of mutagenic transposon activity. These processes determine aging, longevity, and sensitivity of cells and an organism to stress factors (particularly, ionizing radiation). The biogenesis and activity of small RNAs are provided by proteins of the Argonaute family. These proteins participate in the processing of small RNA precursors and the formation of an RNA-induced silencing complex. However, the role of Argonaute proteins in the regulation of lifespan and radioresistance remains poorly explored. We studied the effect of knockdown of Argonaute genes (AGO1, AGO2, AGO3, piwi) in various tissues on the Drosophila melanogaster lifespan and survival after the γ-irradiation at a dose of 700 Gy. In most cases, these parameters were reduced or did not change significantly in flies with tissue-specific RNA interference. Surprisingly, piwi knockdown in both the fat body and the nervous system caused a lifespan increase. But changes in radioresistance depended on the tissue in which the gene was knocked out. In addition, analysis of changes in retrotransposon levels and expression of stress response genes allowed us to determine associated molecular mechanisms.

Radiation is the major driver of snowmelt, and hence its estimation is critically important. Net radiation reaching the forest floor is influenced by vegetation density. Previous studies in mid-latitude conifer forests have confirmed that net radiation decreases and then subsequently increases with increasing vegetation density, for clear sky conditions. This leads to existence of a net radiation minimum at an intermediate vegetation density. With increasing cloud cover, the minimum radiation shifts toward lower densities, sometimes resulting in a monotonically increasing radiation with vegetation density. The net radiation trend, however, is expected to change across sites, affecting the magnitude and timing of individual radiation components. This research explores the variability of net radiation on snow-covered forest floor for different vegetation densities along a latitudinal gradient. We especially investigate how the magnitude of minimum/maximum radiation and the corresponding vegetation density change with the site geographical location. To evaluate these, the net radiation is evaluated using the Forest Radiation Model at six different locations in predominantly white spruce (Picea glauca) canopy cover across North America, ranging from 45 to 66°N latitudes. Results show that the variation of net radiation with vegetation density considerably varies with latitude. In higher latitude forests, the magnitude of net radiation is generally smaller, and the minimum radiation is exhibited at relatively sparser vegetation densities, under clear sky conditions. For interspersed cloudy sky conditions, net radiation non-monotonically varies with latitude across the sites, depending on the seasonal sky cloudiness and air temperature. Latitudinal sensitivity of net radiation is lower on north-facing hillslopes than on south-facing sites.

Astrophysical accretion processes near the black hole candidates, such as active galactic nuclei (AGN), X-ray binary (XRB), and other astrophysical sources, are associated with high-energetic emission of radiation of relativistic particles and outflows (winds and/or jets). It is widely believed that the magnetic field plays a very important role to explain such high energetic processes in the vicinity of those astrophysical sources. In the present research note, we propose that the black hole is embedded in an asymptotically uniform magnetic field. We investigate the dynamical motion of charged particles in the vicinity of a weakly magnetized black hole. We show that in the presence of the magnetic field, the radius of the innermost stable circular orbits (ISCO) for a charged particle is located close to the black hole’s horizon. The fundamental frequencies, such as Keplerian and epicyclic frequencies of the charged particle are split into two parts due to the magnetic field, as an analog of the Zeeman effect. The orbital velocity of the charged particle measured by a local observer has been computed in the presence of the external magnetic field. We also present an analytical expression for the four-acceleration of the charged particle orbiting around black holes. Finally, we determine the intensity of the radiating charged accelerating relativistic particle orbiting around the magnetized black hole.

Several studies have shown that changes in incoming solar radiation and variations of the diffuse fraction can significantly modify the vegetation carbon uptake. Hence, monitoring the incoming solar radiation at large scale and with high temporal frequency is crucial for this reason along with many others. The EUMETSAT Satellite Application Facility for Land Surface Analysis (LSA SAF) operationally disseminates in near real time estimates of the downwelling shortwave radiation at the surface since 2005. This product is derived from observations provided by the SEVIRI instrument onboard the Meteosat Second Generation series of geostationary satellites, which covers Europe, Africa, the Middle East, and part of South America. However, near real time generation of the diffuse fraction at the surface level has only recently been initiated. The main difficulty towards achieving this goal was the general lack of accurate information on the aerosol particles in the atmosphere. This limitation is nowadays less important thanks to the improvements in atmospheric numerical models. This study presents an upgrade of the LSA-SAF operational retrieval method, which provides the simultaneous estimation of the incoming solar radiation and its diffuse fraction from satellite every 15 minutes. The upgrade includes a comprehensive representation of the influence of aerosols based on physical approximations of the radiative transfer within an atmosphere-surface associated medium. This article explains the retrieval method, discusses its limitations and differences with the previous method, and details the characteristics of the output products. A companion article will focus on the evaluation of the products against independent measurements of solar radiation. Finally, the access to the source code is provided through an open access platform in order to share with the community the expertise on the satellite retrieval of this variable.

Radio-fluorogenic (RFG) gels become permanently fluorescent when exposed to high-energy radiation with the intensity of the emission proportional to the local dose of radiation absorbed. An apparatus is described, FluoroTome 1, that is capable of taking a series of tomographic images (thin slices) of the fluorescence of such an irradiated RFG gel on-site and within minutes of radiation exposure. These images can then be compiled to construct a 3D movie of the dose distribution within the gel. The historical development via a laboratory-bench prototype to a readily transportable, user-friendly apparatus is described. Instrumental details and performance tests are presented.

Macrophages exhibit impaired phagocytosis, adhesion, migration, and cytokine production in space, hindering their ability to elicit immune responses. Considering that the combined effect of spaceflight microgravity and radiation is multiscale and multifactorial in nature, it is expected that contradictory findings are common in the field. This theory paper reanalyzes research on the macrophage spaceflight response across multiple timescales from seconds to weeks, and spatial scales from the molecular, intracellular, extracellular, to the physiological. Key findings include time-dependence of both pro-inflammatory activation and integrin expression. Here, we introduce the time-dependent, intracellular localization of MRTF-A as a hypothetical confounder of macrophage activation. We discuss the mechanosensitive MRTF-A/SRF pathway dependence on the actin cytoskeleton/nucleoskeleton, microtubules, membrane mechanoreceptors, hypoxia, oxidative stress, and intracellular/extracellular crosstalk. By adopting a multiscale perspective, this paper provides the first mechanistic answer for a three-decade-old question regarding impaired cytokine secretion in microgravity—and strengthens the connection between the recent advances in mechanobiology, microgravity, and the spaceflight immune response. Finally, we hypothesize MRTF involvement and complications in treating spaceflight-induced cardiovascular, skeletal, and immune disease.

Rapid search and localization for nuclear sources can be an important aspect in preventing human harm from illicit material in dirty bombs or from contamination. In the case of a single mobile radiation detector, there are numerous challenges to overcome such as weak source intensity, multiple sources, background radiation, and the presence of obstructions, i.e., a non-convex environment. In this work, we investigate the sequential decision making capability of deep reinforcement learning in the nuclear source search context. A novel neural network architecture (RAD-A2C) based on the actor critic (A2C) framework and a particle filter gated recurrent unit for localization is proposed. Performance is studied in a randomized 20 x 20 m convex and non-convex environment across a range of signal-to-noise ratio (SNR)s for a single detector and single source. RAD-A2C performance is compared to both an information-driven controller that uses a bootstrap particle filter and to a gradient search (GS) algorithm. We find that the RAD-A2C has comparable performance to the information-driven controller across SNR in a convex environment and at lower computational complexity per action. The RAD-A2C far outperforms the GS algorithm in the non-convex environment with greater than 95% median completion rate for up to seven obstructions.

In this paper, we analyze the Hawking radiation phenomenon for types of Banados-Teitelboim-Zanelli-like (BTZ-like) black holes. For this purpose, using the Hamilton-Jacobi method, we consider semi-classical WKB approximation to calculate the tunneling probabilities of massive boson particles. For these particles, we use the equation of motion for the Glashow-Weinberg-Salam model. Using quantum tunneling process of charged massive bossons, we compute the corresponding Hawking temperatures. Furthermore, we discuss the effects of rotation parameter on tunneling probability and temperature.

Review of the existing bibliography shows that the direction and magnitude of the long-term trends of UV irradiance, and their main drivers, vary significantly throughout Europe. Analysis of total ozone and spectral UV data recorded at four European stations during 1996 – 2017 reveals that long-term changes in UV are mainly driven by changes in aerosols, cloudiness, and surface albedo, while changes in total ozone play a less significant role. The variability of UV irradiance is large throughout Italy due to the complex topography and large latitudinal extension of the country. Analysis of the spectral UV records of the urban site of Rome, and the alpine site of Aosta reveals that differences between the two sites follow the annual cycle of the differences in cloudiness and surface albedo. Comparisons between the noon UV index measured at the ground at the same stations and the corresponding estimates from the DWD forecast model and OMI/Aura observations reveal differences of up to 6 units between individual measurements, which are likely due to the different spatial resolution of the different datasets, and average differences of 0.5 – 1 unit, possibly related to the use of climatological surface albedo and aerosol optical properties in the retrieval algorithms.

The effect of thermal radiation on the two – dimensional, steady-state, conjugate heat transfer from a circular cylinder with an internal heat source in steady laminar crossflow is investigated in this work. P₀ (Rosseland) and P₁ approximations were used to model the radiative transfer. The mathematical model equations were solved numerically. Qualitatively, P₀ and P₁ approximations show the same effect of thermal radiation on conjugate heat transfer; the increase in the radiation – conduction parameter decreases the cylinder surface temperature and increases the heat transfer rate. Quantitatively, there are significant differences between the results provided by the two approximations.

We discuss the topic of the transparency of the Universe in gamma-rays due to the Extragalactic Background Light, and its cosmological and physical implications. Rather than a review, this is a personal account on the development of 30 years of this branch of physical science. Extensive analysis of the currently available information appears to us as revealing a global coherence among the astrophysical, cosmological, and fundamental physics data, or, at least, no evident need so far of substantial modification of our present understanding. Deeper data from future experiments will verify to what extent and in which directions this conclusion should be modified.

Nonionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85-105 GHz MMW irradiation within the ICNIRP (International Commission on Non-Ionizing Radiation Protection) non-thermal 20 mW/cm2 safety standards. Irradiation using a power density of about 1.0 mW/cm2 , SAR over 5-6 hours on 50 cells/μl samples of Saccharomyces cerevisiae model organism resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85-105 GHz range, and was energy and cell density dependent. Irradiation of wild type and Δrad52 (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm2) and compared to that of a compact waveguide (17.17 mW/cm2) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. We have shown that non-thermal MMW radiation has potential for future use in treatment of yeast related diseases and other targeted biomedical outcomes.

A coupled stratospheric chemistry-meteorology model was developed by combining the Canadian operational weather prediction model Global Environmental Multiscale (GEM) with a comprehensive stratospheric photochemistry model from the Belgian Assimilation System for Chemical ObsErvations (BASCOE). The coupled model was called GEM-BACH for GEM-Belgian Atmospheric CHemistry. The coupling was made across a chemical interface that preserves time splitting while being modular, allowing GEM to run with or without chemistry. An evaluation of the coupling was performed by comparing the coupled model, refreshed by meteorological analyses every 6 hours, against the standard offline chemical transport model (CTM) approach. Results show that the dynamical meteorological consistency between meteorological analysis times far outweighs the error created by the jump resulting from the meteorological analysis increments at regular time intervals, irrespective whether a 3D-Var or 4D-Var meteorological analysis is used. GEM-BACH forecast refreshed by meteorological analyses every 6 hours were compared against independent measurements of temperature, long-lived species, ozone and water vapor. The comparison showed a relatively good agreement throughout the stratosphere except for an upper-level warm temperature bias and an ozone deficit of nearly 15%. Arguments in favor of using the same horizontal resolution for chemistry, meteorology, and meteorological analysis increments are also presented. In particular, the coupled model simulation during an ozone hole event gives better ozone concentrations than a 4D-Var chemical assimilation at a lower resolution.

Chromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). This adaptation requires DNA and histone epigenetic modifications, which are mediated by several types of enzymes; among them are lysine methyltransferases (KMTs). Methods: KMT inhibitors, chaetocin and tazemetostat (TZM), were used to study their role in the DDR induced by ionizing radiation or doxorubicin in two human sarcoma cells lines. The effect of these KMT inhibitors was tested by the analysis of chromatin epigenetic modifications, H4K16ac and H4K20me2. DDR was monitored by the formation of γH2AX, MDC1, NBS1 and 53BP1 foci, and the induction of apoptosis. Results: Chaetocin and tazemetostat treatments caused a significant increase of H4K16 acetylation, associated with chromatin relaxation; and increased DNA damage, detected by the labeling of free DNA-ends. These inhibitors significantly reduced H4K20 dimethylation levels in response to DNA damage and impaired the recruitment of 53BP1, but not of MDC1 and NBS1, at DNA damaged sites. This modification of epigenetic marks prevents DNA repair by the NHEJ pathway and leads to cell death. Conclusion: KMT inhibitors can function as sensitizers to DNA damage-based therapies and be used in novel synthetic lethality strategies for sarcoma treatment.

The behavior of convective boundary conditions is studied to delineate their role in heat and mass relegation in the presence of radiation, chemical reaction, and hydromagnetic forces in three-dimensional Powell-Eyring nanofluids. Implications concerning non-Fourier’s heat flux and non-Fick’s mass flux with respect to temperature nanoparticle concentration were examined to discuss the graphical attributes of the principal parameters. An efficient optimal homotopy analysis method is used to solve the transformed partial differential equations. Tables and graphs are physically interpreted for significant parameters

In this paper, the forecast horizon and solar variability influences on MHFM model based on multiscale decomposition, AR and NN models, are studied. This article follows the works published in [1] showing the performance of the MHFM using 3 multiscale decomposition methods and a forecast horizon equal to 1 hour. Several forecast horizon strategies and his influence on the MHFM performances are investigated. We show that the best strategy for a rRMSE variying from $4.43\%$ to $10.24\%$ is obtained for forecast horizons from $5$ minutes to $6$ hours. In a second part, the solar variability influence on the MHFM is studied. A classification based on a shows that the best performance of MHFM is obtained for clear sky days with a rRMSE of $2.91\%$ and worst for cloudy sky days with a rRMSE of $6.73\%$.

Universitas Gadjah Mada (UGM) is implementing the concept of green campus by various means including through elements in its sustainable campus development plan. With regards to several factors related to Energy and Climate Change indicators set by UI GreenMetric, this research examined the existing condition of the area of UGM which belongs to academic zone in order to construct a proposal based on a building mass reconfiguration. This proposal was aimed to improve the implementation of energy-specific green campus concept within the Forestry cluster area as a sample case study. This selection was based on the average value of the Building Coverage Ratio (BCR) values in all of the clusters; thus, the scenario was relevant for generalization and could be replicated in other clusters in the university. The study was done in three stages of simulation, and was based on a series of digital simulation of sunlight hour and solar radiation run in Grasshopper using Lady Bug environmental analysis plug-in for a period of five summer months during the building office hours. Following the reconfiguration, results had shown a similar downtrend between the amount of sunlight hour and solar radiation in the area (up to 49% and 45% respectively on building envelopes, and up to 44% and 42% respectively on landscaping surfaces). This reduction indicated a potential of energy efficiency by applying selective building mass reconfiguration as a passive design strategy that goes hand in hand with the campus’s development policy to optimize the use of BCR for a greener UGM campus through its many undergoing and upcoming redevelopment projects.

The steady-state, coupled heat and mass transfer from a fluid flow to a sphere accompanied by an exothermal catalytic chemical reaction on the surface of the sphere is analysed taking into consideration the effect of thermal radiation. The flow past the sphere is considered steady, laminar and incompressible. The radiative transfer is modeled by P₀ and P₁ approximations. The mathematical model equations were discretized by the finite difference method. The discrete equations were solved by the defect correction – multigrid method. The influence of thermal radiation on the sphere surface temperature, concentration and reaction rate was analysed for three parameter sets of the dimensionless reaction parameters. The numerical results show that only for very small values of the Prater number the effect of thermal radiation on the surface reaction is not significant.

Selected glasses with 10 Na₂O + (90-x) P₂O₅ + x BCD where bypass cement dust (BCD) x value =10, 20, 30 in mol% were synthesized by recognizable melting annealing technique. Cooperative characterization of the prepared glasses were carried out through FTIR and SEM analysis before and after immersed in simulated body fluid (SBF) solution for 13 and 23 days at 37 ^oC. After immersion in SBF, apatite layer is produced on the glass surface after 13 day and increase after 23 day, showing good bioactivity after immersion in the SBF especially for bioglass sample with 30% BCD. A porous hydroxy apatite layer produced on the surface of SBF-glass composite and this layer became denser after more soaking time, periods were extended from 13 to 23 days. Atomic absorption spectroscopy explained the early period of soaking that cause release of both Si and Ca ions through the glass beside decreasing of phosphrous ions. Bioglass (BCD-30) is studied as shielding for gamma, protons and alphas by using Phy-X software, SRIM Monte Carlo simulation code and its subroutine TRIM. The gamma shielding parameters, mass stopping power (MSP), range for both proton (H- ions) and alpha (He- ions) in bioglass- BCD-30 and human bone tissue have estimated. Also, comparison between them is calculated in predicting the radiation damage and atomic displacements per atom (dpa).

Radon gas represents the major contributor to human health risk from environmental radiological exposure. In confined spaces radon can accumulate to relatively high levels so that mitigation actions are necessary. The Italian legislation on radiation protection has set a reference value for the activity concentration of radon at 300 Bq/m3. In this study, measurements of the annual radon concentration in 62 bank buildings, spread on Campania region (Southern Italy), were carried out. Using CR-39 solid-state nuclear track detectors, radon level was assessed in 136 confined spaces (127 at underground and 9 at ground floors), frequented by workers and/or the public. The survey parameters considered in the analysis of the results were: floor types, wall cladding materials, number of openings, door/window opening duration for air exchange. Radon levels were found to be between 17 and 680 Bq/m3, with an average value of 130 Bq/m3 and a standard deviation of 120 Bq/m3. About 7% of the results gave a radon activity concentration above 300 Bq/m3. The analysis showed that the floor level and air exchange have the most significant influence. This study highlighted the importance to assess the indoor radon levels, even in particular environments, to protect public and workers by radon-induced effects on health.

Negative corona discharges occur widely in high voltage transmission lines and charged aircraft, which can cause strong electromagnetic interference. Negative corona discharge is typically performed simultaneously at multiple discharge points. In this study, the current and its EM radiation characteristics of single-needle and multi-needle negative corona discharge in different conditions were tested. The current and electromagnetic radiation characteristics of the two discharge structures were compared. The dipole radiation model was established to analyze the EM radiation characteristics of the negative corona discharge.The results show that, It is only when the voltage reaches a certain threshold that the current and electromagnetic radiation fields of the multi-needle discharge structure will be superimposed and their amplitudes will increase significantly. The frequency of electromagnetic radiation signal does not change with the number of needles, cathode geometry and applied voltage, but only depends on ambient pressure. It provides a basis for detecting corona discharge sources under different conditions.

According to the Cosmological Principle the Universe is isotropic and no preferred direction would be seen by an observer that might be stationary with respect to the expanding cosmic fluid. However, because of observer’s partaking in the solar system peculiar motion, there would appear in some of the observed properties of the Cosmos a dipole anisotropy, which could in turn be exploited to determine the peculiar motion of the solar system. The dipole anisotropy in the Cosmic Microwave Background Radiation (CMBR) has given a peculiar velocity vector 370 km s−1 along l=264∘,b=48∘. However, some other dipoles, for instance, from the number counts, sky brightness or redshift distributions in large samples of distant Active Galactic Nuclei (AGNs), have yielded values of the peculiar velocity many times larger than that from the CMBR, though surprisingly, in all cases the directions agreed with the CMBR dipole. Here we determine our peculiar motion from a sample of 0.28 million AGNs, selected from the Mid Infra Red Active Galactic Nuclei (MIRAGN) sample comprising more than a million sources. From this, we find a peculiar velocity, which is more than four times the CMBR value, although the direction seems to be within ∼2σ of the CMBR dipole. A genuine value of the solar peculiar velocity should be the same irrespective of the data or the technique employed to estimate it. Therefore, such discordant dipole amplitudes, might mean that the explanation for these dipoles, including that of the CMBR, might in fact be something else. But, the observed fact that the direction in all cases, is the same, though obtained from completely independent surveys using different instruments and techniques, by different sets of people employing different computing routines, might nonetheless indicate that these dipoles are not merely due to some systematics, otherwise why would they all be pointing along the same direction. It might instead suggest a preferred direction in the Universe, implying a genuine anisotropy, which would violate the Cosmological Principle, the core of the modern cosmology.

Euglenoids are a common component of primary producers in high acidic and organic shallow freshwater systems. They are free-living photosynthetic motile flagellates exhibiting rapid responses to various external stimuli including chemical pollution. The unique combination of diverse physiological processes of Euglena such as photosynthesis, movement, and orientation offers a range of sensitive criteria that respond to aquatic pollutants. This has led to the development of several acute and chronic assay methods to monitor the adverse impacts of potent toxicants in aquatic ecosystems. Euglenoids also reflect the consequences of physical stress factors such as UV radiation. This review summarizes the ecotoxicity studies using euglenoid flagellates as model species and their potential to contribute toward rapid screening of ecological impacts of pollution in the aquatic environment. Factors determining the reliability of Euglena tests are outlined.

Brachytherapy is often applied to oral cancers, with good outcomes and minimal loss of oral function. Especially, mold brachytherapy is best suited for superficial oral cancers with little or no bone invasion, such as gingival cancer, palatal mucosal cancer, or buccal mucosal cancer because of the thin tissue thickness that needs to be irradiated. A few cases have been reported on mold brachytherapy for gingival cancers, especially with high-dose-rates (HDR), these treatments were performed during hospitalization. We report a case of lower gingival squamous cell carcinoma (SCC) treated with HDR mold brachytherapy in an outpatient setting. A 71-year-old male with lower gingival SCC had received HDR mold brachytherapy (54 Gy, 9 fractions, 5 days) as an outpatient. Eighteen months after the mold therapy, the patient had no recurrence and no metastasis. A search of the literature revealed no previous report of a case of gingival cancer treated with HDR mold brachytherapy in an outpatient.

It is widely believed that the dramatic transformation of the spherical outflows of AGB stars into the extreme aspherical geometries seen during the planetary nebula (PN) phase is linked to binarity and driven by the associated production of fast jets and central disks/torii. The key to understanding the engines that produce these jets and the jet-shaping mechanisms lies in the study of objects in transition between the AGB and PN phases. I discuss the results of our recent studies with high-angular-resolution (with ALMA & HST) and at high-energies (with GALEX, XMM-Newton & Chandra) of several such objects, which reveal new details of close binary interactions and high-speed outflows. These include two PPNe (the Boomerang Nebula and IRAS16342-3814), and the late carbon star, V Hya. The Boomerang is notable for a massive, high-speed outflow that has cooled below the microwave background temperature, making it the coldest object in the Universe. IRAS16342 is the prime example of the class of water-fountain PPNe (very young PPNe with high-velocity H₂O masers) and shows the signature of a precessing jet. V Hya ejects high-speed bullets every 8.5 years associated with the periastron passage of a companion in an eccentric orbit. I discuss our work on AGB stars with strongly-variable high-energy (FUV, X-ray) emission, suggesting that these objects are in the early stages of binary interactions that result in the formation of accretion disks and jets.

The success of boron neutron capture therapy (BNCT) depends mainly on sufficient spatial biodistribution of boron (B-10) localized around or within neoplastic cells to produce a high dose gradient between the tumor and healthy tissue. Contrary to what is usual in radiotherapy, BNCT proposes treatment planning directed at the cell rather than the tumor mass. However, it is not yet possible to precisely determine the concentration of B-10 in a specific tissue in real-time using non-invasive methods. Some critical issues still need to be resolved if BNCT is to become a valuable, minimally invasive, and efficient cancer treatment. This review article provides an overview of the funda-mental principles, recent advances, and future directions of BNCT as a cell-targeted cancer therapy. The main emphasis is on topics related to biological dosimetry, methods for assessing boron concentration, mechanisms of action of BNCT, and its physical bases for clinical implementation.

Since its initial development in the 1970’s by Phil Burke and his collaborators, the R-matrix theory and associated computer codes have become the de facto approach for the calculation of accurate data for general electron-atom/ion/molecule collision and photoionization processes. The use of a non-orthonormal set of orbitals based on B-splines, now called the B-spline R-matrix (BSR) approach, was pioneered by Zatsarinny. It has considerably extended the flexibility of the approach and improved particularly the treatment of complex many-electron atomic and ionic targets, for which accurate data are needed in many modelling applications for processes involving low-temperature plasmas. Both the original R-matrix approach and the BSR method have been extended to the interaction of short, intense electromagnetic (EM) radiation with atoms and molecules. Here we provide an overview of the theoretical tools that were required to facilitate the extension of the theory to the time domain. As an example of a practical application, we show results for two-photon ionization of argon by intense short-pulse extreme ultraviolet radiation

Abstract: High-dose-rate interstitial brachytherapy (HDR-ISBT) has recently come to be considered one of the most effective treatments for oral cancer. On the other hand, it is important to note that radiation therapy has some side effects. Especially, radiation-induced malignancy is probably the most serious complication affecting long-term survivors. We report a case of a radiation-induced undifferentiated spindle cell sarcoma that developed following HDR-ISBT for tongue squamous cell carcinoma (SCC). A 39-year-old woman with right tongue SCC underwent HDR-ISBT (60 Gy, 10 fractions, 8 days) treatment. Five years and one month later, a tumor had developed at the primary site. Surgery was performed for the tumor, which was histopathologically diagnosed as an undifferentiated spindle cell sarcoma. That was distinct from the squamous cell origin of the primary cancer. According to recently established criteria for radiation-induced malignancy, this case was classified as a radiation-induced sarcoma. A search of the literature revealed no previous report of radiation-induced malignancy following HDR-ISBT for tongue cancer.

Search for periodic signals from blazars has become widely discussed topic in recent years. This is because periodic signals bear imprints of the processes occurring near the innermost regions of blazars which are mostly inaccessible to our direct view. Such signals provide insights into various aspect of blazar studies including disk-jet connection, magnetic field configuration and, more importantly, strong gravity near the supermassive black holes and release of gravitational waves from the binary supermassvie black hole systems. In this work, we report detection of a periodic signal in the radio light curves of the blazar J1043+2408 spanning ~10.5 years. We performed multiple methods of time series analysis, namely, epoch folding, Lomb-Scargle periodogram, and discrete auto-correlation function. All three methods consistently reveal a repeating signal with a periodicity of ~563 days. To robustly account for the red-noise processes usually dominant in the blazar variability and other possible artifacts, a large number of Monte Carlo simulations were performed. This allowed us to estimate a high significance (99.9% local and 99.4% global) against possible spurious detection. As possible explanations, we discuss a number of scenarios including binary supermassive black hole system, Lense-Thirring precession, and jet swing and precession.

Ag/TiO₂ thin films were prepared using the sol-gel spin coating method. The microstructural growth behaviors of the prepared Ag/TiO2 thin films were elucidated using real-time synchrotron radiation imaging, its structure determined using grazing incidence X-ray diffraction (GIXRD), its morphology imaged using the field emission scanning electron microscopy (FESEM), and its surface topography examined using the atomic force microscope (AFM) in contact mode. Cubical white spots were detected, identified as Ag, while the TiO₂ thin film resembles a porous ring-like structure with each ring coalescing and forming channels. Junction growth is directly proportional with time under continuous heating conditions (annealing), and its growth orientations and patterns were seemingly random.

The black hole information paradox is one of the most puzzling paradoxes in physics. Black holes trap everything that falls into them, while their mass may leak away through purely thermal Hawking radiation. When a black hole vanishes, all the information locked inside, if any, is just lost, thus challenging the principles of quantum mechanics. However, some information does have a way to escape from inside the black hole, that is, through gravitational waves. Here, a concise extension of this notion is introduced. When a black hole swallows something, whether it is a smaller black hole or an atom, the system emits gravitational waves carrying the information about the “food”. Although most of the signals are too weak to be detected, the information encoded within them will persist in the universe. This speculation provides an explanation for a large part, if not all, of the supposed “information loss” in black holes, and thus reconciles the predictions of general relativity and quantum mechanics.

Tanning beds have been classified as carcinogenic to humans. As a result, many countries have enacted laws regulating the use of commercial tanning beds, including bans for minors. However, there is no international overview of the current legal status of access restrictions for minors that provides details on their specific design regarding age limits and possible exceptions to the statutory regulation. Therefore, we performed a comprehensive web search of current tanning bed legislation for minors on the three continents North America, Australia, and Europe. Our findings regarding existence and concrete design of access restrictions are presented graphically using maps. We found a wide variety of different legislations. In Australia, a total ban on tanning beds exists, while in New Zealand tanning bed use is banned for minors. In Europe about half of the countries have implemented a strict ban for minors. In North America we found differences in the age limit for access restrictions between the states, provinces and territories for those regions that implemented a ban for minors. In the United States, some states have rather ‘soft bans’ that allow use by minors with different types of parental consent. The patchwork in legislation calls for harmonization. Therefore, our comparison is an important starting point for institutions such as the World Health Organization or the European Commission to advance their goals towards a harmonization of tanning bed legislation in general and for minors in particular.

Previously, we demonstrated that IR triggers the invasion/migration of A549 cells via activation of an EGFR–p38/ERK–STAT3/CREB-1–EMT pathway. Here, we have demonstrated the involvement of a novel intracellular signaling mechanism in γ-ionizing radiation (IR)-induced migration/invasion. Expression of receptor-interacting protein (RIP) 1 was initially increased upon exposure of A549, a non-small cell lung cancer (NSCLC) cell line, to IR. IR-induced RIP1 is located downstream of EGFR and involved in the expression/activity of matrix metalloproteases (MMP-2 and MMP-9) and vimentin, suggesting a role in epithelial-mesenchymal transition (EMT). Our experiments showed that IR-induced RIP1 sequentially induces Src-STAT3-EMT to promote invasion/migration. Inhibition of RIP1 kinase activity and expression blocked induction of EMT by IR and suppressed the levels and activities of MMP-2, MMP-9, and vimentin. IR-induced RIP1 activation was additionally associated with stimulation of the transcriptional factor NF-κB. Specifically, exposure to IR triggered NF-κB activation and inhibition of NF-κB suppressed IR-induced RIP1 expression followed by a decrease in invasion/migration as well as EMT. Based on the collective results, we propose that IR concomitantly activates EGFR and NF-κB and subsequently triggers the RIP1–Src/STAT3–EMT pathway, ultimately promoting metastasis.

In the presented paper, a comprehensive study will be done on shape factor analysis of MoS2-GO in H2O-C2H6O2 based hybrid nanoliquids associated with effect and influence of transverse magnetic field and thermal radiation. The effect of variation in different parameters and nanoliquids shapes under temperature and velocity distribution is explored and also non-linear thermal radiation will be analyzed. Algorithms are introduced in proportion to mathematical modeling based on their numerical results and comparative curves for further explanation. In addition, it will be done research for influence and effect of new significant parameters emerged to the model to do sensitivity analysis and also their output results are demonstrated, examined and compared together by presenting graphs and tables. Based on detailed discussions, authentication of attained results designates the high accuracy of applied methods deployed to solve presented model in the paper. Our results satisfy that our used approach is accurate, highly reliable and also effective. All mentioned steps will be described throughout the literature.

Azo dyes are the most widely used synthetic dyes in the printing and dyeing process. However, the discharge of untreated azo dyes poses potential threat for human health and aqueous ecosystem. Herein, we fabricated a novel heterogenous catalyst - activated carbon fiber-supported ferric alginate (FeAlg-ACF) . Together with peroxymonosulfate (PMS) and visible light, this photocatalytic oxidation system was used to remove an azo dye - azophloxine. The results indicated that the proposed catalytic oxidation system can remove 100% azophloxine within 24 min, while under the same system, the removal rate was only 92 % and 84 % when ferric alginate was replaced with ferric citrate and ferric oxalate respectively, which showed the superiority of activated carbon fiber-supported ferric alginate. The degradation of azophloxine is achieved by the active radicals (SO4•− and •OH) released from PMS and persistent free radicals from activated carbon fiber. After treating for 24 min, the total organic carbon of azophloxine solution (50 μmol/L) decreased from 1.82 mg/L to 79.3 μg/L and the nitrate concentration of ions increased from 0.3 mg/L to 8.6 mg/L. That is, up to 93.5% azophloxine molecules were completely degraded into inorganic compounds. Consequently, potential secondary contamination by intermediate organic products during catalytic degradation was prohibited. The azophloxine removal ratio was kept almost constant after seven cycles, indicating the recyclability and longevity of this system. Furthermore, the azophloxine removal was still promising at high concentrations of Cl-, HCO3-, CO32-. Therefore, our proposed system is potentially effective to remove dye pollutants from seawater. It provides a feasible method for the development of efficient and environmental friendly PMS activation technology combined with FeAlg-ACF, has significant academic and application value.

Physicians often label anatomical structure sets in Digital Imaging and Communications in Medicine (DICOM) images with nonstandard names. As these names vary widely, the standardization of the nonstandard names in the Organs at Risk (OARs), Planning Target Volumes (PTVs), and 'Other' organs inside the area of interest is a vital problem. Prior works considered traditional machine learning approaches on structure sets with moderate success. This paper presents integrated deep learning methods applied to structure sets by integrating the multimodal data compiled from the radiotherapy centers administered by the US Veterans Health Administration (VHA) and the Department of Radiation Oncology at Virginia Commonwealth University (VCU). The de-identified radiation oncology data collected from VHA and VCU radiotherapy centers have 16,290 prostate structures. Our method integrates the heterogeneous (textual and imaging) multimodal data with Convolutional Neural Network (CNN)-based deep learning approaches like CNN, Visual Geometry Group (VGG) network, and Residual Network (ResNet). Our model presents improved results in prostate (RT) structure name standardization. Evaluation of our methods with macro-averaged F1 Score shows that our deep learning model with single-modal textual data usually performs better than the previous studies. We also experimented with various combinations of multimodal data (masked images, masked dose) besides textual data. The models perform well on the textual data alone, while the addition of imaging data shows that deep neural networks can achieve improved performance using information present in the other modalities. Additionally, using masked images and masked doses along with text leads to an overall performance improvement with the various CNN-based architectures than using all the modalities together. Undersampling the majority class leads to further performance enhancement. The VGG network on the masked image-dose data combined with CNNs on the text data performs the best and establishes the state-of-the-art in this domain.

Since the accident of Fukushima Nuclear Power plant in 2011, people have been more interested in radiation safety in life. This study investigated the level of exact recognition of 6 warning pictograms enacted and utilized as per Korea Industrial Regulation in relation to medical & natural radiation safety at this time. Unless people recognize pictogram prepared for radiation safety correctly in accordance with its purpose, safety would be severely intimidated. The result of corroboratively analyzing recognition of radiation safety pictogram is as follows. First, some 63.3% of respondents negatively responded on understanding 6 pictograms related to radiation in life, showing low level of understanding. Second, the average mark of correct response on the questions asking the meaning of 6 pictograms presented in relation to radiation safety in life was 2.79 point (standard deviation 1.447 point), which was relatively low. As seen above, the level of recognition & comprehension is low, because education related to life radiation safety in the school is insufficient and the present warning pictogram established by Korea Industrial Regulation needs to be revised & supplemented. This study is meaningful in that the method of using pictogram is presented as one of diverse efforts to improve life radiation safety.

During the explosion of energetic materials, obvious electromagnetic interference will be generated, which will affect the normal operation of surrounding electronic equipment. Experiments are still an important means to study this issue. A set of electromagnetic radiation measurement device based on short-wave omnidirectional antenna and ultra-wideband omnidirectional antenna is designed to measure the electromagnetic radiation generated by the explosion of energetic materials of different masses, and the electromagnetic radiation characteristics are obtained through data processing. The results show that the mass of the energetic material has a significant effect on the time-domain characteristics of the electromagnetic radiation generated by the explosion: the higher the mass of the energetic material, the shorter the delay response of the electromagnetic signal, the longer the duration, and the earlier the peak appears. The frequency of electromagnetic radiation signals generated by the explosion of energetic materials is mainly concentrated below 100 MHz, and the energy is most concentrated in the frequency band of 0~50 MHz. The composition of energetic materials has the greatest influence on the spectral distribution, and the spectral distribution of electromagnetic radiation produced by the explosion of explosives with different compositions has obvious specificity. The electromagnetic radiation intensity generated by the explosion of energetic materials has a strong correlation with the distance from the explosion center, and it decreases with the increase of the distance, and the decreasing range is large. The structure and detonation method of energetic materials can change the geometrical motion mode during the explosion, resulting in the non-uniformity of electromagnetic radiation propagation.

The COVID-19 pandemic caused an unprecedented effect on national radiological investigations. Since the World Health Organization officially declared the COVID-19 as a global pandemic, health policies have been rapidly organized to limit the spread of the virus and decrease the risk of exposure. These restrictions, in combination with home-stay arrangements and the onset of economic recession. As a result of public policies, financial difficulties and patient fear, many radiology departments have suffered a significant reduction in diagnostic examinations with important implications for their economic stability. The aim of this work is to evaluate the economic impact of the COVID-19 pandemic in the Radiology Department of an infectious disease hospital.

Nonionizing millimeter-waves (MMW) are reported to interact with cells in a variety of ways. Possible mechanisms of the inhibited cell division effect were investigated using 85-105 GHz MMW irradiation within the ICNIRP (International Commission on Non-Ionizing Radiation Protection) non-thermal 20 mW/cm² safety standards. ~1.0 mW/cm² exposure over 5-6 hours treatment on 50 cells/μl samples of Saccharomyces cerevisiae model organism, resulted in 62% growth rate reduction compared to control (sham). The effect was specific for 85-105 GHz range and energy dose and cell density dependent. Irradiation of wild type and Δrad52 (DNA damage repair gene) deletion cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm²) and compared to that of a compact waveguide (17.17 mW/cm²) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. Combinations of MMW mediated Structure Resonant Energy Transfer (SRET), membrane modulations eliciting signaling effects, and energetic resonance with biomolecules were indicated to be responsible for the observations reported. Our results provide novel mechanistic insights enabling innovative applications of nonionizing radiation procedures for eliciting targeted biomedical outcomes.

The radiosensitivity of biological systems is strongly affected by the system oxygenation. On the nanoscopic scale and molecular level, this effect is considered to be strongly related to the indirect damage of radiation. Even though particle track radiolysis has been the object of several studies, still little is known about the nanoscopic impact of target oxygenation on the radical yields. We present here an extension of the chemical module of the Monte Carlo particle track structure code TRAX, taking into account the presence of dissolved molecular oxygen in the target material. The impact of the target oxygenation level on the chemical track evolution and the yields of all the relevant chemical species is studied in water under different irradiation conditions: different linear energy transfer (LET) values, different oxygenation levels, and different particle types. Especially for low LET radiation, a large production of two highly toxic species (HO₂^• and O₂^•− ), which are not produced in anoxic conditions, is predicted and quantified in oxygenated solutions. The remarkable correlation between the HO₂^• and O₂^•− production yield and the oxygen enhancement ratio observed in biological systems suggests a direct or indirect involvement of HO₂^• and O₂^•− in the oxygen sensitization effect. The results are in agreement with available experimental data and previous computational approaches. An analysis of the oxygen depletion rate in different radiation conditions is also reported.

The study of long-term average weather patterns is known as climatology. It is a distinct field of study from meteorology and can be broken down into several subdivision. In order to predict the future, the knowledge of climatology is essential. In other words, with the help of climatology, we can figure out how likely it is that snow and hail will fall to the ground, and how much solar thermal radiation can reach a certain location etc. Climatology often focuses on how the climate has changed over time and how it has affected people and events. Both meteorology and climatology fall under the general term "meteorology", in particular, they are subdivision of research in the same field. In case of predicting the weather, meteorologists use variables such as humidity, air pressure, and temperature. This article's primary objective is to familiarize engineers with the fundamentals of climate and its processes so that they can effectively apply this knowledge to comprehend the climatic impact on water resources systems.

Astronauts in space are subject to a continuous bombardment of ionizing radiation. The Earth's magnetic field and the ISS shield some biologically damaging particles traveling through. Still, travel beyond low-Earth orbit and extravehicular activities are exceedingly more dangerous and there is a concern for the acute and late-occurring adverse health effects befalling astronauts. So, it is vital to consider the current tools and models used to describe and study the organic consequences of ionizing radiation exposure. It is equally important to see where these models may improve. This article reviews the historical development and current state of knowledge of radiation effects impacting astronauts in orbit. We explain the space radiation environment, cellular microenvironment, and how these may be incorporated in radiobiological models to aid in our understanding of the influence space travel may have on astronaut health. The topics discussed in this paper include a review of DNA damage and repair mechanisms and the numerical models that aim to explain the biological effects resulting from ionizing radiation damage. Historically, radiobiological models focused on how radiation damages nuclear DNA, built upon the hypotheses of Crowther and Lea in the 1940s and 1960s, and neglected other sub-cellular targets outside of nuclear DNA.

Background: Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. Methods: Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n=496) was utilized. The immune microenvironment was characterized using the CIBERSORTX tool to identify immune cell type composition. Unsupervised hierarchical clustering was performed based on immune cell type content. Analyses of progression-free survival (PFS), distant metastases, and overall survival (OS) were performed using Kaplan-Meier estimates and Cox-regression multivariable analyses. Results: Four immune clusters were identified, largely defined by plasma cell, CD4+ Memory Resting T Cells (CD4 MR), M0 and M2 macrophage content (CD4 MRHighPlasma CellHighM0LowM2Low, CD4 MRLowPlasma CellHighM0LowM2Low, CD4 MRHighPlasma CellLowM0HighM2Low, and CD4 MRHighPlasma CellLowM0LowM2High). The two macrophage-enriched/plasma cell non-enriched clusters (3&4) demonstrated worse PFS (HR 2.24, 95% CI 1.46–3.45, p=0.0002) than the clusters 1&2. No metastatic events occurred in the non-macrophage-enriched clusters. Comparing clusters 3 vs 4, in patients treated by surgery alone, cluster 3 had zero progression events (p<0.0001). However, cluster 3 patients had worse outcomes after post-operative radiotherapy (p=0.018). Conclusion: Distinct tumor immune clusters with a macrophage-enriched phenotype and reduced plasma cell enrichment independently characterize an aggressive phenotype in localized prostate cancer that may differentially respond to treatment.

Solar radiation prediction is an important process in ensuring optimal exploitation of solar energy power. Numerous models have been applied to this problem, such as numerical weather prediction models and artificial intelligence models. However, well-designed hybridization approaches that combine numerical models with artificial intelligence models to yield a more powerful model can provide a significant improvement in prediction accuracy. In this paper, we propose novel hybrid machine learning approaches that exploit auxiliary numerical data. The proposed hybrid methods invoke different machine learning paradigms, including feature selection, classification, and regression. Additionally, numerical weather prediction (NWP) models are used in the proposed hybrid models. Feature selection is used for feature space dimension reduction to reduce the large number of recorded parameters that affect estimation and prediction processes. The rough set theory is applied for attribute reduction and the dependency degree is used as a fitness function. We investigate the effect of the attribute reduction process with thirty different classification and prediction models in addition to the proposed hybrid model. Then, different machine learning models are constructed based on classification and regression techniques to predict solar radiation. Moreover, other hybrid prediction models are formulated to use the output of the numerical model of Weather Research and Forecasting (WRF) as learning elements in order to improve the prediction accuracy. The proposed methodologies are evaluated using a data set that is collected from different regions in Saudi Arabia.

In the present paper, the effect of the non-linear thermal radiation on the neutral gas mixture in the unsteady state is investigated for the first time. The unsteady BGK technique of the Boltzmann kinetic equations for a neutral non-homogenous gas is solved. The solution of the unsteady case makes the problem more general significance than the stationary one. For this purpose, the moments' method, together with the traveling wave method, is applied. The temperature and concentration are calculated for each gas component and mixture for the first time.Furthermore, the study is held for aboard range of temperatures ratio parameter and a wide range of the molar fraction. The distribution functions are calculated for each gas component and the gas mixture. The significant non-equilibrium irreversible thermodynamic characteristics the entire system is acquired analytically. That technic allows us to investigate the consistency of Boltzmann's H-theorem, Le Chatelier principle, and thermodynamics laws. Moreover, the ratios among the different participation of the internal energy alteration are evaluated via the Gibbs formula of total energy. The final results are utilized to the argon-helium non-homogenous gas at different magnitudes of radiation force strength and molar fraction parameters. 3D-graphics are presented to predict the behavior of the calculated variables, and the obtained results are theoretically discussed.

Considered is “time as an interval” including time from the past and from the future, in contrast to time as a moment. Equilibrium as the basis for a description of changing properties in physics is understood to depend on the “mean velocity theorem”, while a “time” of equilibrium resembles a center of weight. This turns out to be a good method to derive properties for any function of time t including space coordinates q(t) and expressions for the time dependent Hamiltonian. Introduced are derivatives depending on time intervals instead of time moments and with these a new relation between the Lagrangian L and the Hamiltonian H. As an application introduced is a step by step method to integrate stationary state “local” time interval measurements to beyond “locality” in General Relativity. Because of limits on the measures of the resulting time intervals and their asymmetry, this allows for a probabilistic interpretation of quantities that have these intervals as time domain in QM. Their asymmetry also questions the time reversal symmetry of GR. Another application of time intervals is the discussion of the measurement of starlight radiation energy and QM wave packet collapse as an example of a time dependent Hamiltonian. Finally a relation between starlight frequency, metric and space- and time intervals is found. Discussed is how finite and asymmetric time intervals correspond to time dependent H and symmetric infinite time intervals to a time independent H. From there, in cosmological perspective, finite time intervals can help to describe how entropy change could relate to dark energy.

In this work, we examine the deflection angle of black hole in effective loop quantum gravity in non-plasma medium via the geometrical technique of Gibbons and Werner in weak field limits. For this, we attain the optical metric and calculate the Gaussian optical curvature and then we apply the Gauss-Bonnet theorem. We also study the influence of the plasma and dark matter mediums on the deflection angle. Further, we obtain the deflection angle by using Keeton and Petters method. We also calculate the Hawking temperature via Gauss-Bonnet theorem. In addition, we determine the fermionic greybody bounds. Moreover, we discuss the graphical behaviour of the bending angle and bounds on the greybody factor. We also examine that the results obtained for the black hole in effective loop quantum gravity are reduces to the Schwarzschild black hole solutions when dimensionless non-negative parameter $A_{\lambda}=0$.

The recent provision of energy-harvesting capabilities to wireless sensor networks has entailed the redefinition of design objectives. Specifically, the traditional goal of maximizing network lifetime has been replaced by optimizing network performance, namely delay and throughput. The present paper contributes to this reformulation by considering the routing problem for the class of time-driven energy-harvesting WSN (EH-WSN) under regular or quasi-periodic energy sources. In particular, this paper shows that the minimum hop count (MHC) criterion maximizes the average duty cycle that can be sustained by nodes in this type of scenarios. This is a primary objective in EH-WSN, since large duty cycles lead to enhanced performance. Based on a previous result, a general expression is first obtained which gives mathematical form to the relationship between duty cycle and traffic load for any node in a time-driven EH-WSN fed by a regular energy source. This expression reveals that the duty cycle achievable by a node decreases as its traffic load increases. Then, it is shown that MHC minimizes the average traffic load over the network, and thus it maximizes the average duty cycle of nodes. This result is numerically validated via simulation by comparison with other well-known routing strategies. Accordingly, this paper suggests assigning top priority to the MHC criterion in the development of routing protocols for time-driven EH-WSN under regular energy sources.

The spatial resolution measurement limitation of the position-momentum uncertainty principle is shown to mathematically originate from the Bekenstein entropy bound and the associated second law of thermodynamics, as a special case in which a statistical thermodynamic distribution of energies is specialized to a fixed, definite probe energy equal to the average energy of that distribution. This is used in combination with the Wein displacement law to predict an ultraviolet cutoff for Planck blackbody radiation at about ⅛ of the Wein peak. A new UV photon counting experiment is proposed to test for this. A physical understanding of these results may be provided by a UV-complete, intelligible theory of general relativistic quantum mechanics in which the observation of a blackbody spectrum is simply a remote observation of Hawking radiation emitted from black hole fluctuations in the gravitational vacuum.

(1) Background: Investigating the characteristics of photosynthetic physiological changes of leaves in Mangifera indica L. cv. 'GuIfei' under enhanced UV-B radiation, natural light exposed trees were regarded as control, and 96 kJ·m-2·d-1enhanced UV-B radiation was artificially simulated in the field; (2) Methods: The changes of fruit maturity and fruit quality, leaf net photosynthetic rate (Pn), photosynthetic pigments contents, photochemical reaction, activities of photosynthetic enzymes and their genes expressions were determined; (3) Results: Compared with CK, the percentage of mature fruits of the treatment was significantly increased, and fruit quality was better. The net photosynthetic rate (Pn), the contents of photosynthetic pigment, Hill reaction activity and photochemical quenching coefficient (qP) of the treatment leaves showed a significantly higher trend than CK. The activities of Rubisco and RCA, and the expression of Rubisco genes rbcL and rbcS were significantly increased; (4) Conclusions: 96 kJ·m-2·d-1 enhanced UV-B radiation treatment improved Rubisco activity through increasing the expression of Rubisco genes rbcL and rbcS, thereby enhancing the CO2-fixing capacity and dark reaction capacity of leaves. Based on this, it raised the net photosynthetic rate of leaves, which promoted the early maturity of 'Guifei' mango by the fast accumulating photosynthetic products.

There is a rich history of cancer treatments which provides a number of important lessons for present and future cancer therapies. We outline this history by looking in the past, reviewing the current landscape of cancer treatments, and by glancing at the potential future cancer therapies.

Vacuum pump wear is the most prevalent failure mode of the IBA Synthera® automated radiochemistry system. Rebuilding or replacing the pump causes equipment downtime and increases the radiation exposure of the service personnel. We built a dedicated test device to assess new or rebuilt pumps prior to installation, thus reducing downtime and radiation exposure during repairs. The Testbed incorporates a microprocessor that actuates the pump, valves, pressure sensor, and communicates with the user through lights, buttons, and an alphanumeric screen. The Testbed increases productivity and safety in the radiochemistry laboratory.

Recent analyses of cosmic microwave background (CMB) maps have been interpreted as demonstrating that the Universe was born without an initial rotation. However, these analyses are based on unrealistic models and do not contain essential ingredients such as quantum effects, the strong, weak and gravitational interactions between the components, their intrinsic spins and magnetic moments, as well as primordial black holes. If the Universe was born spinning these effects would distribute the initial spin angular momentum among its components long before the CMB forms at recombination. A primordial spin would now appear as a nonzero total angular momentum of its components along the direction of the original spin, and a primordial large-scale rotation would no longer be apparent. The existence of a special axis or direction would break a fundamental symmetry assumed in general relativity, cosmic isotropy, and a net angular momentum implies a cosmic parity violation.

We explore the deflection angle in the framework of improved Schwarzschild Black hole utilizing the most advance geometrical path adopted by Gibbon-Werner. To investigate deflection angle of the photon ray by weak gravitational lensing for this black hole, we derive the optical curvature and perform the application of Gauss-Bonnet theorem on the optical metric. Moreover, we study the impacts of the plasma medium in context of the weak gravitational lensing in relate to this black hole. Further, we also study the graphical analysis of the deflection angle in both the plasma and non-plasma mediums. Also, we find the rigorous bound base upon the greybody factor for improved Schwarzschild black hole. A while later, we contrast our conclusions about deflection angle with the deflection angles of Schwarzschild black hole within plasma and non-plasma mediums.

Patient derived model systems are important tools for studying novel anti-cancer therapies. Patient derived xenografts (PDXs) have gained favor over the last 10 years as newer mouse strains have improved the success rate of establishing PDXs from patient biopsies. PDXs can be engrafted from head and neck cancer (HNC) samples across a wide range of cancer stages, retain the genetic features of their human source, and can be treated with both chemotherapy and radiation, allowing for clinically relevant studies. Not only do PDXs allow for study of patient tissues in an in vivo model, they can also provide a renewable source of cancer cells for organoid cultures. Herein, we review the uses of HNC patient derived models for radiation research including approaches to establishing both orthotopic and heterotopic PDXs, approaches and potential pitfalls to delivering chemotherapy and radiation to these animal models, biological advantages and limitations, and alternatives to animal studies that still use patient-derived tissues.

Maxwell's equations in vacuum provide the negative speed of light -c, which leads to imaginary Planck units. However, the second, negative fine-structure constant $\alpha_2^{-1} \approx -140.178$, present in the Fresnel coefficients for the normal incidence of electromagnetic radiation on monolayer graphene, establishes the different, negative speed of light in vacuum $c_2 \approx -3.06 \times 10^8~\text{[m/s]}$, which introduces imaginary Planck units different in magnitude from those parametrized with $c$. Furthermore, algebraic relations between the fine-structure constant hint that the fine-structure constant does not vary over time. It follows that electric charges are the same in real and imaginary dimensions. We model neutron stars and white dwarfs, emitting perfect black-body radiation, as \textit{objects} having energy exceeding their mass-energy equivalence ratios. We define complex energies in terms of real and imaginary natural units. Their imaginary parts, inaccessible for direct observation, store the excess of these energies. It is conjectured that the maximum atomic number $Z=238$. A black-body \textit{object} is in the equilibrium of complex energies if its radius $R_\text{eq} \approx 1.3833~R_{\text{BH}}$, which is close to the photon sphere radius $R_{\text{ps}}=1.5~R_{\text{BH}}$, and marginally greater than a locally negative energy density bound of $4/3~R_{\text{BH}}$. The complex force between real masses and imaginary charges leads to the black-body object's surface gravity and generalized Hawking radiation temperature, which includes its charge. Furthermore, this force agrees with the physical parameters of the hydrogen atom. The proposed model takes into account the value(s) of the fine-structure constant(s), which is/are otherwise neglected in general relativity, and explains the registered (GWOSC) high masses of neutron stars' mergers and the associated fast radio bursts (CHIME) without resorting to any hypothetical types of exotic stellar \textit{objects}.

Analytical solutions for radiation dominated phase of Quasi Steady State Cosmology in Friedmann-Robertson-Walkar models are obtained. We find that matter density is positive in all the cases (k = 0,-1,1). The nature of Hubble parameter (H) in [0,2] is discussed. The deceleration parameter (q) is marginally less than zero indicating accelerating universe. The scale factor (S) is graphically shown with time. The model represents oscillating universe between the above mentioned limits. Because of bounce in QSSC, the maximum density phase is still matter dominated. The models represent singularity free model. We also find that the models have event horizon i.e. no observer beyond the proper distance rH can communicate each other in FRW mdels for radiation dominated phase in the frame work of QSSC. The FRW models are special classes of Bianchi type I, V, IX space-times with zero, negative and positive curvatures respectively. Initially i.e. at  = 0, the model represents steady model. We have tried to show how a good fit can be obtained to the observations in the framework of QSSC during radiation dominated phase.

Conformal radiotherapy is a primary treatment in head and neck cancer, which putative adverse effects depend on relatively low doses of radiation delivered to increased volumes of normal tissues. Systemic effects of such treatment include radiation-induced changes in serum lipid profile, yet dose- and volume-dependence of these changes remain to be established. Here we analyzed levels of choline-containing phospholipids in serum samples collected consecutively during the radiotherapy used as the only treatment modality. The LC-MS approach applied in the study enabled the detection and quantitation of 151 phospholipids, including (lyso)phosphatidylcholines and sphingomyelins. No statistically significant differences were found in the pre-treatment samples from patients with different location and stage of cancer. To compensate for potential differences between schemes of radiotherapy the biologically effective doses were calculated and used in the search of correlations with specific lipid levels. We found that the levels of several phospholipids depended on the maximum dose delivered to the gross tumor volume and total radiation energy absorbed by the patient’s body. Increased doses correlated with increased levels of sphingomyelins and reduced levels of phosphatidylcholines. Noteworthy, serum phospholipid levels were associated mainly with volumes of normal tissues irradiated with relatively low doses (i.e., total accumulated dose 20 Gy), which indicated the importance of such effects on the systemic response of the patient’s organism to IMRT.

Radiation Fireballs are singular phenomena which involve severe thermal radiation and consequently, they need to be duly assessed and prevented. Although the radiative heat transfer produced by a sphere is relatively well known, the shadowing measures implemented to control the fireball’s devastating effects have frequently posed a difficult analytical instance, mainly due to its specific configuration. In this article, since the usual solving equations for the said cases are impractical, the authors propose a novel graphic-algorithm method that sorts the problem efficiently for different kinds of obstructions and relative positions of the fireball and the defenses. Adequate application of this method may improve the safety of a significant number of facilities exposed to such risks.

A method for generating fluoroscopic (time-varying) volumetric images using patient-specific motion models derived from 4-dimensional cone-beam CT (4D-CBCT) images is developed. 4D-CBCT images acquired immediately prior to treatment have the potential to accurately represent patient anatomy and respiration during treatment. Fluoroscopic 3D image estimation is done in two steps: 1) deriving motion models and 2) optimization. To derive motion models, every phase in a 4D-CBCT set is registered to a reference phase chosen from the same set using deformable image registration (DIR). Principal components analysis (PCA) is used to reduce the dimensionality of the displacement vector fields (DVFs) resulting from DIR into a few vectors representing organ motion found in the DVFs. The PCA motion models are optimized iteratively by comparing a cone-beam CT (CBCT) projection to a simulated projection computed from both the motion model and a reference 4D-CBCT phase, resulting in a sequence of fluoroscopic 3D images. Patient datasets were used to evaluate the method by estimating the tumor location in the generated images compared to manually defined ground truth positions. Experimental results showed that the average tumor mean absolute error (MAE) along the superior-inferior (SI) direction and the 95th percentile in two patient datasets were (2.29 mm and 5.79 mm) for patient 1 and (1.89 mm and 4.82 mm) for patient 2. This study has demonstrated the feasibility of deriving 4D-CBCT-based PCA motion models that have the potential to account for the 3D non-rigid patient motion and localize tumors and other patient anatomical structures on the day of treatment.

To investigate the photosynthetic change characteristics of mango leaves under enhanced UV-B radiation, adult ‘Tainong No. 1’ mango (Mangifera indica) trees were treated (N=nine individuals) with simulated enhanced UV-B radiation [24 and 96 kJ/(m2·d)] in the field, and the photochemical reactions, activities of key enzymes in carbon assimilation, and the expression of genes were observed. The results showed that compared with the control, there was a decrease in tree yield and nutritional flavor quality of the fruits under the 96 kJ/(m2·d) treatment, while no significant changes were observed under 24 kJ/(m2·d). After 20 or 40 days, leaves’ net photosynthetic rate (Pn), stomatal conductance (Sc), transpiration rate (Tr), intercellular CO2 concentration (Ci), and chlorophyll a/b under exposure to 96 kJ/(m2·d) of UV-B were significantly lower than in the control, whereas chlorophyll a, chlorophyll b, carotenoids, Hill reaction activity, photochemical quenching coefficient (qP), and Rubisco activities were significantly higher. By contrast, the Hill activity and Rubisco activity under 24 kJ/(m2·d) were significantly higher than the control, while Pn, Sc, Tr, Ci, and the content of photosynthetic pigments were similar to the control. The expression of gene coding the Rubisco big subunit (rbcL) was inhibited by the 96 kJ/(m2·d) treatment. We conclude that stomatal limitation was directly induced by 96 kJ/(m2·d), resulting in the inhibition of photosynthesis and the reduction in yield and deterioration of the quality of mango.

Nuclear pollution is an urgent environmental issue as a consequence of rapid industrialization and nuclear accidents in the past. Remediation of nuclear polluted sites using microbial vital activity (bioremediation) is a promising approach to recover contaminated areas in an environmentally friendly and cost-saving way. At the same time, the number of known bacterial and archaeal species able to withstand extremely high doses of ionizing radiation is steadily growing every year, together with growing knowledge about mechanisms of radioresistance. This opens up new opportunities for developing new biotechnological solutions. However, these data are often not systemized and it can be difficult to access. Here, we present the Determinants of Radioresistance Database, or DetR DB (http://extremebiolab.com/detr-db/), gathering a comprehensive catalog of radioresistant microbes and their molecular and genetic determinants of enhanced ionizing radiation tolerance. The database provides search tools including taxonomy, common gene name, and BLAST. DetR DB will be a useful tool for research community by facilitating the extraction of the necessary information to help further analysis of radiation-resistant mechanisms.

Electrical properties of the thin films of poly(arylene ether ketone) copolymers (co-PAEKs) with the fraction of phthalide-containing units of 3, 5 and 50 mol% in the main chain were investigated by using radiation induced conductivity (RIC) measurements. Transient current signals and current-voltage (I-V) characteristics were obtained under exposing 20÷25 thick films of the co-PAEKs to monoenergetic electron pulses of the energy ranged from 3 to 50 keV in the electric field ranged from 5 to 40 V/μm. The Rose-Fowler-Vaisberg semi-empirical model based on a multiple trapping formalism was used for an analysis of the RIC data and the parameters of the highly dispersive charge carrier transport were evaluated. The analysis revealed that charge carriers moved in isolation from each other and the applied electric fields were below the threshold field triggering the switching effect (a reversible high-to-low resistivity transition) in the co-PAEK films. It was also found that the co-PAEK films due to the super-linear I-V characteristics are highly resistant to electrostatic discharges arising from the effects of ionizing radiation. This property is important for the development of protective coatings for electronic devices.

Mirrors are a subset of optical components essential for the success of current and future space missions. Most of the telescopes for space programs ranging from Earth Observation to Astrophysics and covering the whole electromagnetic spectrum from X-rays to Far-Infrared are based on reflective optics. Mirrors operate in diverse and harsh environments that range from Low-Earth Orbit, to interplanetary orbits and the deep space. The operational life of space observatories spans from minutes (sounding rockets) to decades (large observatories), and the performance of the mirrors within the mission lifetime is susceptible to degrade, which results in a drop of the instrument throughput, which in turn affects the scientific return. Therefore, the knowledge of potential degradation mechanisms, how they affect mirror performance, and how to prevent them is of paramount importance to ensure the long-term success of space telescopes. In this review we report an overview on current mirror technology for space missions with a focus on the importance of degradation and radiation resistance of the coating materials. A special attention will be given to degradation effects on mirrors for the far and extreme UV as in these ranges the degradation is enhanced by the strong absorption of most contaminants.

High frequency knowledge of the spatio-temporal distribution of the Downwelling Surface Shortwave Flux (DSSF) and its diffuse fraction (fd) at the surface is nowadays essential for understanding climate processes at the surface-atmosphere interface, plant photosynthesis and carbon cycle, and for the solar energy sector. The EUMETSAT Satellite Application Facility for Land Surface Analysis operationally delivers estimation of the MDSSFTD (Downwelling Surface Short-wave radiation Fluxes – Total and Diffuse fraction) product with an operational status since the year 2019. The method for the retrieval was presented in the companion paper [40]. The part 2 now focuses on the evaluation of the MDSSFTD algorithm and presents the comparison of the corresponding outputs, i.e. total DSSF and diffuse fraction (fd) components, against in-situ measurements acquired at four BSRN stations over a seven-month period. The validation is performed on an instantaneous basis. We show that the satellite estimates of DSSF and fd meet the target requirements defined by the user community for all-sky (clear and cloudy) conditions. For DSSF, the requirements are 20Wm^-2 for DSSF<200Wm^-2, and 10% for DSSF>=200Wm^-2. The MBE and rMBE compared to the ground measurements are 3.618Wm^-2 and 0.252%, respectively. For fd, the requirements are 0.1 for fd<0.5, and 20% for fd>=0.5. The MBE and rMBE compared to the ground measurements are -0.044 and -17.699%, respectively. The study also provides a separate analysis of the product performances for clear sky and cloudy sky conditions. The importance of representing the cloud-aerosol radiative coupling in the MDSSFTD method is discussed. Finally, it is concluded that the quality of the Aerosol Optical Depth (AOD) forecasts currently available is enough accurate to obtain reliable diffuse solar flux estimates. This quality of AOD forecasts was still a limitation a few years ago.

Using a detailed atmospheric radiative transfer model, we derive macroscopic relationships of downwelling and outgoing longwave radiation, useful for hydrological practice. We validate them using empirical formulae based on downwelling radiation data, which are in common use in hydrology, as well as satellite data for the outgoing radiation. We use the macroscopic relationships to infer the relative importance of carbon dioxide and water vapour in the greenhouse effect. The results show that the contribution of the former is 4% – 5%, while water and clouds dominate with a contribution of 87% – 95%. The minor effect of carbon dioxide is also confirmed by the small, non-discernible effect of the recent escalation of atmospheric CO2 concentration from 300 to 420 ppm, which is quantified at 0.5% for both downwelling and outgoing radiation. Water and clouds also perform other important functions in climate, such as regulating the heat storage and the albedo, as well as cooling the Earth’s surface though latent heat transfer, with a contribution of 50%. By confirming the major role of water on climate, these results suggest that hydrology should have a more prominent and more active role in climate research.

Hydroa vacciniforme (HV) is a rare form of photosensitivity disorders in children and is frequently associated with Epstein-Barr virus (EBV) infection, whereas HV-like lymphoproliferative disorders (HVLPD) describe a spectrum of EBV-associated T-cell or NK-cell lymphoproliferations with HV-like cutaneous manifestations, including EBV-positive HV, atypical HV, and HV-like lymphoma. Classic HV occurs in childhood with vesiculopapules on sun-exposed areas, which is usually induced by sunlight and ultraviolet irradiation, and mostly resolves by early adult life. Unlike classic HV, atypical or severe HV manifests itself as recurrent papulovesicular eruptions in sun-exposed and sun-protected areas associated occasionally with facial edema, fever, lymphadenopathy, oculomucosal lesions, gastrointestinal involvement, and hepatosplenomegaly. Notably, atypical or severe HV may progress to EBV-associated systemic T-cell or natural killer (NK)-cell lymphoma after a chronic course. Although rare in the United States and Europe, atypical or severe HV and HV-like lymphoma are predominantly reported in children from Asia and Latin America with high EBV DNA levels, low numbers of NK cells, and T cell clones in the blood. In comparison with the conservative treatment used for patients with classic HV, systemic therapy such as immunomodulatory therapy is recommended as the first-line therapy for patients with atypical or severe HV. This review aims to provide an integrated, overview of current evidence and knowledge of HV and HVLPD to elucidate the pathophysiology, practical issues, environmental factors, and the impact of EBV infection.

This paper focuses on the combination of the method of moments and the wire-grid approximation as an effective computational technique for modeling symmetrical antennas with low computational cost and quite accurate results. The criteria and conditions for the use of wire-grid surface approximation from various sources are presented together with new recommendations for modeling symmetrical antenna structures using the wire-grid approximation. These recommendations are used to calculate the characteristics of biconical and horn antennas at different frequencies. The results obtained using different grid and mesh settings are compared to those obtained analytically. Moreover, the results are compared to those obtained using the finite difference time domain numerical method, as well as the measured ones. All results are shown to be in a good agreement. The used recommendations for building a symmetrical wire-grid of those symmetrical antenna elements provided the most advantageous parameters of the grid and mesh settings and the wire radius, which are able to give a quite accurate results with low computational cost. Additionally, the known equal area rule was modified for a rectangular grid form. The obtained radiation patterns of a conductive plate using both the original rule and the modified one are compared with the electrodynamic analysis results. It is shown that the use of the modified rule is more accurate when using a rectangle grid form.

The future power equipment tends to take hydrogen or middle/low heat-value syngas as fuel for low emission. The heat transfer of film cooled turbine blade shall be influenced more by radiation. Its characteristic of conjugate heat transfer is studied experimentally and numerically in the paper by considering radiation heat transfer, multi-composition gas and TBC. The Weighted Sum of Gray Gases spectral model and Discrete Transfer Model are utilized to solve the radiative heat transfer in the multi-composition field, while validated against the experimental data for the studied cases. It is shown that the plate temperature increases significantly when considering the radiation and the temperature gradient of the film cooled plate becomes larger. It is also shown that increasing percentage of steam in gas composition results in increased temperature on the film-cooled plate. The normalized temperature of the film-cooled plate decreases about 0.02, as the total percentage of steam in hot gas increases per 7%. As for the TBC effect, it can smooth out the the temperature distribution and insulate the heat to a greater extent when the radiative heat transfer becomes significant.

During the launch and return of a spacecraft, the intense combustion of propellants generates strong electromagnetic radiation, which interferes with the operation of electronic equipment in the spacecraft. To improve the electromagnetic compatibility of electronic equipment in spacecraft, it is necessary to study the electromagnetic radiation characteristics of rocket fuel. An electromagnetic radiation measurement system based on antennas is designed to measure the electromagnetic radiation generated by rocket fuel, and the electromagnetic radiation characteristics are obtained through data analysis. The mechanism of the electromagnetic radiation generated by rocket fuel is comprehensively analysed through the spatial, time-domain, frequency-domain, and energy-domain characteristics. A characterization model is established to provide a reliable scheme for evaluating the influence of rocket fuel electromagnetic radiation on electronic equipment in spacecraft.

The development of gamma rays mutant rice lines would be a solution for introducing variability in already farmer using varieties. In vitro gamma (60Co) mutagenesis reduces chimeras and allows a faster selection of desired traits but requires laboratory process optimization. The objective of the present work was the in vitro establishment of a recalcitrant rice embryogenic calli, the determination of its sensitivity to gamma radiation (Co-60), sequencing MATK and Rubisco for identification purposes, as well as generation optimization. The radiosensitivity of embryogenic calli resulted in an LD50 of 110Gy, while the 20% lethal dose was 64Gy. All sequenced genes matched perfectly with already reported MATK and Rubisco O. sativa genes with a clear SNP that identifies the local variety related to the southeast Asia Region. Callus induction improves with an MS with 2mg/L 2,4D, and the regeneration was achieved with an MS medium with 3mg/L BAP and 0,5mg/L NAA. The optimized radiation condition was 60Gy with an 83% regeneration in a semisolid medium, allowing a balance between mutation and regeneration. When increased to 80Gy, the regeneration rate falls to 29%. An immersion system (RITA®) of either 60 or 120 seconds every 8hours allowed a systematic and homogeneous total regeneration of the recalcitrant line, in contrast with the semisolid medium that resulted in positive but irregular regeneration. Other well-known recalcitrant cultivars, CR1821, CR1113 also had an improving regeneration in the immersion system, demonstrating its potential use for recalcitrant materials. To our knowledge, this is the first report on using an immersion system to allow regeneration of gamma-ray mutants from recalcitrant rice materials.

Glioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant tumors, including glioma. BNCT involves boron-10-released radiation directly into tumor cells with minimal damage to healthy tissues. This therapy lacks clinically approved targeted blood-brain-barrier-permeating delivery vehicles for therapeutic drug/ boron-10. Nanoparticles, particularly gold nanoparticles (GNPs), are selective and effective drug-delivery vehicles because of their desirable properties, facile synthesis, and biocompatibility. This review discusses historical and current GNP therapeutic applications as a drug delivery vehicle for treating glioma. Furthermore, GNPs loaded with therapeutic drugs, imaging agents, and GBM-targeting antibodies/ peptides to treat GBM will be discussed. Additionally, the importance of upper and lower limits on therapeutic efficacy will be described and explored followed by highlighting their advantages, limitations, and possible toxicity. Recent research and selected important findings for GNP-mediated pharmaceutics in GBM will also be considered.

Hyper-radiosensitivity (HRS) is the increased sensitivity to low doses of ionizing radiation observed in most cell lines. We previously demonstrated that HRS is permanently abolished in cells irradiated at a low dose rate (LDR), in a mechanism dependent on transforming growth factor β3 (TGF-β3). In this study, we aimed to elucidate the activation and receptor binding of TGF-β3 in this mechanism. T-47D cells were pre-treated with inhibitors of potential receptors and activators of TGF-β3, along with addition of small extracellular vesicles (sEVs) from LDR primed cells, before their radiosensitivity was assessed by the clonogenic assay. The protein content of sEVs from LDR primed cells was analyzed with mass spectrometry. Our results show that sEVs contain TGF-β3 regardless of priming status, but only sEVs from LDR primed cells remove HRS in reporter cells. Inhibition of the matrix metalloproteinase (MMP) family prevents removal of HRS, suggesting an MMP-dependent activation of TGF-β3 in the LDR primed cells. We demonstrate a functional interaction between TGF-β3 and activin receptor like kinase 1 (ALK1), by showing that TGF-β3 removes HRS through ALK1 binding, independent of ALK5 and TGF-βRII. These results are an important contribution to a more comprehensive understanding of the mechanism behind TGF-β3 mediated removal of HRS.

Background: Boron Neutron Capture Therapy (BNCT) is an emerging radiotherapy. There are ongoing efforts to develop a Canadian accelerator-based BNCT center. However, it remains unclear how Canadian radiation oncologists (RO), medical physicists (MP), and their trainees perceive BNCT and its impact on radiation oncology as a discipline. Methods: A survey was created to explore knowledge of BNCT, its clinical role, and support for Canadian research. It was distributed through the Canadian Association of Radiation Oncology (CARO) and Canadian Organization of Medical Physicists (COMP). Results: We received 118 valid responses from all 10 provinces, from 70 RO (59.3%) and 48 MP (40.7%), including 9 residents. Most knew of BNCT and its indications (60.2%). Although many were unaware of reasons behind early failures (44.1%), common reasons were lack of clinical trials and inaccessibility of neutron sources (42.4%) and reactor unsuitability (34.7%). Additionally, 90.6% showed definite (66.9%) or possible (23.7%) support for Canadian BNCT research, while 89% indicated definite (56.8%) or possible (32.2%) willingness for BNCT referrals. Conclusions: Most RO and MP supported Canadian BNCT research and would refer patients. However, limited awareness and lack of experiences remain a challenge. Educational sessions are needed to realize this innovative cancer treatment in Canada.

The measurements of the proton electromagnetic form factors in the time-like region using the initial state radiation technique are reviewed. Recent experimental studies have shown that initial state radiation processes at high luminosity electron-positron colliders can be effectively used to probe the electromagnetic structure of hadrons. The BABAR experiment at the B-factory PEP-II in Stanford and the BESIII experiment at the $\tau$-charm factory BEPC-II in Beijing have measured the time-like form factors of the proton using the initial state radiation process $e^{+}e^{-}\to pbar{p}\gamma$. The two kinematical regions where the photon is emitted from the initial state at small and large polar angles have been investigated. In the first case the photon is in the region not covered by the detector acceptance and is not detected. The Born cross section and the proton effective form factor have been measured over a wide and continuous range of the the momentum transfer squared $q^2$ from threshold up to ~42 (GeV/c)$^2$. The ratio of electric and magnetic form factors of the proton has been also determined. In this report, the theoretical aspect and the experimental studies of the initial state radiation process $e^{+}e^{-}\to p\bar{p}\gamma$ are described. The measurements of the Born cross section and the proton form factors obtained in these analyses near the threshold region and in the relatively large $q^2$ region are examined. The experimental results are compared to the predictions from theory and models. Their impact on our understanding of the nucleon structure is discussed.

Employing data supplied by the Oxford-based UK Childhood Cancer Research Group in 2003 it is shown that after the Chernobyl accident, childhood leukemia by single age and year of birth in the 0-4y cohort increased significantly in Wales and Scotland combined in the period 1986-1990 compared with controls born 1970-1985 and 1991-1994. Relative risk RR = 1.41; 95% CI 1.20<RR<1.65; p = 0.00004. These exposure periods were chosen because whole body Caesium-137 monitoring had demonstrated that internal exposures persisted for more than 4 years. The dose-response exhibits saturation and reversal, interpreted as biological censoring effects in the developing individual.

The recent happenings in the world such as flood and wild forest fire were as a result of climate effect as being envisaged by scientists. It is urgent now to adopt a source of energy that will eliminate this effect on our universe. Solar energy is the major energy means that is abundant which could be utilized. In this review, the prospects of solar energy exploration were studied in Nigeria which include assessments, economic viability and hybrid systems. Findings show higher potential in the North as compared to the Southern region. Additionally, potential of offshore solar energy system was simulated by considering 2002, 2003 and 2004 data sets from Era5-land base. Their monthly mean, seasonal changes and annual mean value were estimated. The algebraic annual solar radiance for 2002, 2003 and 2004 were 34,914.732 kWh/m2, 33,898.316 kWh/m2 and 34,338.324 kWh/m2. Suggestions were made due to the present status of solar energy utilization that will enhance its maximum usage and development. One of these is the establishment of a functioning financial scheme and the database for all renewable energy systems. When all these are put in place, the energy supply will increase, climate effect will be reduced, and the economy will be boosted.

The sustainability of the planet and its inhabitants is in dire danger and is among the highest priorities on global agendas such as the Sustainable Development Goals (SDGs) of the United Nations (UN). Solar energy -- among other clean, renewable, and sustainable energies -- is seen as essential for environmental, social, and economic sustainability. Predicting solar energy accurately is critical to increasing reliability and stability, and reducing the risks and costs of the energy systems and markets. Researchers have come a long way in developing cutting-edge solar energy forecasting methods. However, these methods are far from optimal in terms of their accuracies, generalizability, benchmarking, and other requirements. Particularly, no single method performs well across all climates and weathers due to the large variations in meteorological data. This paper proposes SENERGY (an acronym for Sustainable Energy), a novel deep learning-based auto-selective approach and tool that, instead of generalising a specific model for all climates, predicts the best performing deep learning model for GHI forecasting in terms of forecasting error. The approach is based on carefully devised deep learning methods and feature sets through an extensive analysis of deep learning forecasting and classification methods using ten meteorological datasets from three continents. We analyse the tool in great detail through a range of metrics and methods for performance analysis, visualization, and comparison of solar forecasting methods. SENERGY outperforms existing methods in all performance metrics including Root Mean Square Error (RMSE), Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE), Forecast Skills (FS), Relative Forecasting Error, and the normalised versions of these metrics. The proposed auto-selective approach can be extended to other research problems such as wind energy forecasting and predict forecasting models based on different criteria (in addition to the minimum forecasting error used in this paper) such as the energy required or speed of model execution, different input features, different optimisations of the same models, or other user preferences.

Background: Painful spinal bone metastases (PSBMs) patients regularly receive palliative radiation therapy (RT) with response rates in about 2 of 3 patients. In this exploratory study, we evaluated the value of machine learning (ML) models based on radiomic, semantic and clinical features to predict complete pain response. Methods: Gross tumour volumes (GTV) and clinical target volumes (CTV) of 261 PSBMs were segmented on planning computed tomography (CT) scans. Radiomic, semantic and clinical features were collected for all patients. Random forest (RFC) and support vector machine (SVM) classifiers were compared using repeated nested cross-validation.Results: The best radiomic classifier was trained on CTV with an area under the receiver-operator curve (AUROC) of 0.62 ± 0.01 (RFC; 95% confidence interval). The semantic model achieved a comparable AUROC of 0.63 ± 0.01 (RFC), significantly below the clinical model (SVM, AUROC: 0.80 ± 0.01); and slightly lower than the spinal instability neoplastic score (SINS; LR, AUROC: 0.65 ± 0.01). A combined model did not improve performance (AUROC: 0,74 ± 0,01).Conclusions: We could demonstrate that radiomic and semantic analyses of planning CTs allowed for limited prediction of therapy response to palliative RT. ML predictions based on established clinical parameters achieved the best results.

More than twenty-five years ago the Global Solar UV index (UVI) has been introduced as a simple means of visualizing the intensity of ultraviolet radiation and to alert people to the need for sun protection. In our survey among directors of 436 kindergartens in southern Germany we investigated the level of awareness and knowledge about the UVI as well as the practical consequences for sun protection in kindergartens. Less than half of the directors (n=208, 47.7%) had ever heard of the UVI, and only a small minority of them (n=34, 8.7%) used the daily UVI information to adapt sun protective measures in their kindergartens. Detailed knowledge about the UVI was a rarity among the respondents. The proportion of respondents with self-perceived detailed UVI knowledge was five times higher than actual knowledge assessed by an in-depth structured interview using open-ended questions about the UVI (14.2% vs. 2.8%). No clear relationship of UVI awareness, knowledge, and use to directors' age and gender was found. The UVI-related variables also showed no association with directors' knowledge of risk factors for skin cancer and their attitudes towards tanned skin. Overall, the results paint a sobering picture regarding the penetration of the UVI into sun protection policies of German kindergartens. Future public health campaigns should target increasing awareness and understanding of the UVI as well as its importance for sun protection of children.

In our study we investigated the accelerated aging process of PLA under 253.7 nm UV-C irradiation with the use of GPC, NMR, FTIR, DSC methods and formal kinetic analysis. The results of GPC and DSC indicated a significant degree of destructive changes in PLA macromol-ecules, while spectroscopic methods NMR and FTIR showed maintenance of PLA main structural elements even after a long time of UV exposure. In addition to that, the GPC method displayed the formation of a high-molecular fraction starting from 24 hours of irradiation, and an increase in its content after 144 hours of experiment. It has been showed for the first time that a distinctive feature of prolonged UV exposure is the occurrence of intra- and intermolecular radical recom-bination reactions, leading to the formation of a high-molecular fraction of PLA decomposition products. This causes the observed slowdown of the photolysis process. It was concluded that photolysis of PLA is a complex of physicochemical processes, the mechanism of which depends on morphological changes in a solid phase of the polymer under UV radiation.

We examine here the discrepancy between the radiated power, calculated from the Poynting flux at infinity, and the power loss due to radiation reaction for an accelerated charge. It is emphasized that one needs to maintain a clear distinction between the electromagnetic power received by distant observers and the mechanical power loss undergone by the charge. In literature both quantities are treated as almost synonymous, the two in general could, however, be quite different. It is shown that in the case of a periodic motion, the two formulations do yield the power loss in a time averaged sense to be the same, even though, the instantaneous rates are quite different. It is demonstrated that the discordance between the two power formulas merely reflects the difference in the power going in self-fields of the charge between the retarded and present times. In particular, in the case of a uniformly accelerated charge, power going into the self-fields at the present time is equal to the power that was going into the self-fields at the retarded time plus the power going in acceleration fields, usually called radiation. From a comparison of the far fields with the instantaneous location of the uniformly accelerated charge, it is shown that all its fields, including the acceleration fields, remain around the charge and are not radiated away from it.

The Casimir effect can either work over very short distances or at very low temperatures. At the cosmic scale, we naturally deal with long distances, but at the same time, we encounter extraordinarily low temperatures, namely the CMB (Cosmic Microwave Background) tem- perature. Recently, there has been increased interest in the Casimir effect and its implications in cosmology. Here, we briefly demonstrate that the luminosity and radiation pressure of the CMB is mathematical identical to a theoretical Casimir effect within the Hubble sphere, or actually our solution seems to be valid for any Schwarzschild black hole. The Casimir effect forevery Schwarzschild black hole is identical. This also include the Hubble sphere if we treat it as a Schwarzschild black hole that is related to increased interest in black hole cosmology.

UVA radiation inducing oxidative stress is harmful for the skin cells. The most sensitive are dermal fibroblasts. Exposure of the cells to prolonged UVA radiation induces apoptosis. Although, skin cells have a number of defense mechanisms that protect them against UV-induced oxidative stress, they are insufficient during long-lasting UV exposure. Therefore, there is a need for effective skin protection compounds with cytoprotective and antioxidant properties. One of their sources is Amaranthus cruentus L. seed oil, rich in unsaturated fatty acids, squalene, vitamin E derivatives, and phytosterols. The aim of this study was to evaluate whether Amaranthus cruentus seed oil evokes protective effect on the apoptosis stimulated by UVA radiation in human skin fibroblasts. UVA radiation at an applied dose of 10 J/cm2 caused a significant reduction in the survival of human skin fibroblasts and directed them into apoptosis pathway. Increased expression of p53, caspase 3, and caspase 9 and PARP proteins in UVA-treated fibroblasts suggests the intrinsic mechanism of apoptosis. The application of Amaranthus cruentus seed oil at 0.1% and 0.15% concentrations to UVA-treated cells decreased the expression of these proteins, which was accompanied by increased cell survival. Similarly, the UVA-dependent decrease in expression of p-Akt and mTOR proteins was restored, under the effect of studied oil. The molecular mechanism of this phenomenon is related to the stimulation of antioxidant processes through activation of Nrf2. This suggests that Amaranthus cruentus seed oil stimulate the antioxidant system in fibroblast cells and prevent the effects of UVA-induced oxidative stress and may find application in pharmacy and cosmetology as a sun- protective substance.

Radiation therapy (RT) is one of the main approaches of cancer therapy, including non-small cell lung cancer (NSCLC). Radiation-induced DNA double-stranded breaks (DSBs), single-stranded DNA breaks (SSBs) and oxidized nucleobases cause replication fork stalling, chromosomal instability or point mutagenesis and can lead to cell death. Translesion DNA synthesis (TLS) is one of the DNA damage tolerance (DDT) pathways promoting replication of damaged DNA. Here, we explored the effects of the knockout of primase-polymerase PRIMPOL (PRIMPOL −/−) and TLS polymerase POLI (POLI −/−) genes in two different monoclonal lines derived from human NSCLC A549 cells. Our study aimed to investigate the impact of their absence on the susceptibility of these cells to ionizing radiation (IR)-induced stress. Without IR, cells that do not have PRIMPOL or POLI experience a considerable rise in apoptosis by day 7 of continuous cultivation and a noteworthy decline in cell migration under spatial confinement when compared to the parental wild-type cells. Despite this, we have found that PRIMPOL −/− exhibited higher clonogenic survival compared to wild-type cell lines in response to IR stress. Both of these cell lines demonstrated remarkable resilience to radiation stress, surpassing the survival rate of the original A549 cells. POLI deficiency reduces cellular γH2AX foci accumulation, while the presence of highest number of γH2AX foci in PRIMPOL−/− cells was ATM-independent. We report for the first time that increased post-irradiation clonogenic survival of PRIMPOL −/− A549 cells might be associated with the increase of CD133+ but not CD44+ populations of cancer stem-like cells.

The search for periodic signals from blazars has become an actively pursued field of research in recent years. This is because periodic signals bring us information about the processes occurring near the innermost regions of blazars, which are mostly inaccessible to our direct view. Such signals provide insights into some of the extreme conditions that take place in the vicinity of supermassive black holes that lead to the launch of the relativistic jets. In addition, studies of characteristic timescales in blazar light curves shed light on some of the challenging issues in blazar physics that includes disk-jet connection, strong gravity near fast rotating supermassive black holes and release of gravitational waves from binary supermassive black hole systems. However, a number of issues associated with the search for quasi-periodic oscillations (QPOs) in blazars e.g., red-noise dominance, modest significance of the detection, periodic modulation lasting for only a couple of cycles and their transient nature, make it difficult to estimate the true significance of the detection. Consequently, it also becomes difficult to make meaningful inferences about the nature of the on-going processes. In this proceedings, results of study focused on searching for QPOs in a number of blazar multi-frequency light curves are summarized. The time series analyses of long term observations of the blazars revealed the presence of year-timescale QPOs in the sources including OJ 287 (optical), Mrk 501 (gamma-ray), J1043+2408 (radio) and PKS 0219 -164 (radio). As likely explanations, we discuss a number of scenarios including binary supermassive black hole systems, Lense–Thirring precession, and jet precession.

Downward short-wave (SW) solar radiation is the only essential energy source powering the atmospheric dynamics, ocean dynamics, biochemical processes, etc. on our planet. Clouds are the main factor limiting the SW flux over the land and the Ocean. For the accurate meteorological measurements of the SW flux one needs expensive equipment - pyranometers. For some cases where one does not need golden-standard quality of measurements, we propose estimating incoming SW radiation flux using all-sky optical RGB imagery which is assumed to incapsulate the whole information about the SW flux. We used DASIO all-sky imagery dataset with corresponding SW downward radiation flux measurements registered by an accurate pyranometer. The dataset has been collected in various regions of the World Ocean during several marine campaigns from 2014 to 2022, and it will be updated. We demonstrate the capabilities of several machine learning models in this problem, which are multilinear regression, Random Forests, Gradient Boosting and convolutional neural networks (CNN). We also applied the inverse target frequency (ITF) re-weighting of the training subset and the approach of pre-classification in order to raise the SW flux approximation quality. We found that the CNN is capable of approximating downward SW solar radiation with higher accuracy compared to existing empiric parameterizations. We also found that the ITF reweighting of the training subset increases the approximation quality substantially. The estimates of the SW radiation flux using all-sky imagery may be of particular use in case of the need for the fast radiative budgets assessment of a site.

Targeted delivery of drugs or other therapeutic agents through internal or external triggers has been used to control and accelerate the release from liposomal carriers in a number of studies, but relatively few utilize energy of therapeutic X-rays as a trigger. We have synthesized liposomes that are triggered by ionizing radiation (RTLs) to release their therapeutic payload. These liposomes are composed of natural egg PE, DSPC, cholesterol, and DSPE-PEG-2000, and the mean size of the RTL was in the range of 114 to 133 nm, as measured by NTA. The trigger mechanism is the organic halogen, chloral hydrate, which is known to generate free protons upon exposure to ionizing radiation. Once protons are liberated, a drop in internal pH of the liposome promotes destabilization of the lipid bilayer and escape of the liposomal contents. In proof of principle studies, we assessed RTL radiation-release of fluorescent tracers upon exposure to a low pH extracellular environment or exposure to X-ray irradiation. Biodistribution imaging before and after irradiation demonstrated a preferential uptake and release of the liposomes and their cargo at the site of local tumor irradiation. Finally, a potent metabolite of the commonly used chemotherapy irinotecan, SN-38, was loaded into RTL along with near infrared (NIR) fluorescent dyes for imaging studies and measuring tumor cell cytotoxicity alone or combined with radiation exposure, in vitro and in vivo. Fully loaded RTLs were found to increase tumor cell killing with radiation in vitro and enhance tumor growth delay in vivo after three i.v. injections combined with three, 5 Gy local tumor radiation exposures compared to either treatment modality alone.

The emergence of Non-Ionizing Radiation (NIR) has stimulated the growth and advancement of technological civilization. NIR is ubiquitous; it has helped improve all fields and even deepened democratic processes through the transfer of data and electronic transmission of results etc. A breathtaking part of NIR is its recent application in the treatment of adverse health effects through radiofrequency ablation, phototherapy, etc. as summarized in Table 1. The benefits of NIR are enormous, however, technological civilization has not come without a cost; some of the adverse health effects associated with NIR include skin cancers, sleep disorders, photo-aging, etc. as summarized in Table 2. Therefore, with the rapid and sporadic increase in the sources of NIR from Natural and Artificial sources including fossil fuel burning, Starlink technology, mobile phones, mobile base antennas, etc., background radiation is expected to rise beyond the exposure limit leading to health illnesses. Intrinsically, there is a dare need to marry concerns that evolve with this growth. Hence, this review article aims to congregate the health hazards associated with NIR and the state-of-the-art applications of NIR in medicine and the health sector in Nigeria being a developing country. Part of our recommendations is that the government at all levels should set up enforcement agencies and policies to drive strict adherence to NIR as provided by ICNIRP; frequent-periodic assessments of background radiation in public places should be carried out due to the increasing sources. In addition, further research is needed to ascertain the health hazard from emerging sources of NIR like Starlink technology and to substantiate findings of non-thermal effects.

Up to now, many studies have been performed on particle radiations before or during earthquakes (EQs). In our previous study, with the help of piezoelectricity relationships and the elastic energy formula, the MCNPX simulation code was applied to find the amount of created atomic/ nuclear particles, the dominant interactions; and the energy of the particles for various sizes of quartz and granite blocks. In this study, using the MCNPX simulation code, we have estimated the flux of the particles (created from under-stressed granitic rocks) at different distances from the EQ hypocenter inside the fractures, filled with air, water, and CO2. It was found that inside a water-filled fracture, the particles do not show the flux far from the EQ hypocenter, but inside the gases like air and CO2 with the normal condition density, different types of particles can have a flux far from the source (more than a kilometer) and they might reach themselves to the surface in the case that the EQ hypocenter is very shallow (0- 5 km). However, for deep EQs, it seems that the most detected nuclear particles on the surface should pass via the vacuum-filled fractures and reach themselves to the surface. Moreover, it was concluded that the more density of the fracture’s filling fluid, the less distance that the particles can have a flux.

X-rays production through betatron radiation emission from electron bunches is a valuable resource for several research fields. The EuAPS (EuPRAXIA Advanced Photon Sources) project, within the framework of the EuPRAXIA project, aims to provide 1-10 keV photons (soft X-rays) developing a compact plasma-based system designed to exploit self-injection processes that occur in highly nonlinear laser-plasma interaction (LWFA) to drive electron betatron oscillations. Since the emitted radiation spectrum, intensity, angular divergence, and possible coherence strongly depend on the properties of the self-injected beam, accurate preliminary simulations of the process are necessary to evaluate the optimal diagnostic device specifications. Dedicated tools for these tasks are under development: electron trajectories from particle-in-cell (PIC) simulations are currently undergoing numerical analysis through the calculation of retarded fields and spectra for various plasma and laser parameter combinations. At the same time, an analytical approach is being examined to obtain an expression for the emitted spectrum, assuming linear or quadratic electron energy variation. Code structure and some trajectories analysis results are presented.

Prostate cancer (PCa) is most commonly observed in male patients. Although PCa progresses relatively slowly, high-risk PCa is associated with an increased risk of lymph nodes, distant metastases, and PCa-related death. Several guidelines recommend radiation therapy (RT) of the prostate combined with long-term androgen deprivation therapy for high-risk PCa. A comparison of clinical outcomes between radical prostatectomy (RP) and RT for high-risk PCa by propensity score-matched analysis showed that RP had a significantly higher risk of biochemical recurrence than RT. However, the combination of neoadjuvant chemohormonal therapy followed by RP may be more likely to achieve a cure when overall survival is considered the primary endpoint. In this review, we aimed to confirm the oncological outcomes of RP and RT for high-risk PCa and highlight the importance of neoadjuvant therapy followed by RP for high-risk PCa.

2003 it is shown that after the Chernobyl accident, childhood leukemia by single age and year of birth in the 0-4y cohort increased significantly in Wales and Scotland combined in the period 1986-1990 compared with controls born 1970-1985 and 1991-1994. Relative risk RR = 1.41; 95% CI 1.20<RR<1.65; p = 0.00004. These exposure periods were chosen because whole body Caesium-137 monitoring had demonstrated that internal exposures persisted for more than 4 years. The dose-response exhibits saturation and reversal, interpreted as biological censoring effects in the developing individual.

The radiation stability of polymer test objects fabricated by direct laser writing is studied. The two groups of 6 cubes (50×50×50 μm3) were printed on a common silicon substrate. 6 cubes were irradiated with X-rays in the synchrotron radiation beam (12 keV, 1010 photons/mm2/s), the other 6 kept non-irradiated for the reference. In each group, the fabrication parameters (laser power and slicing step) were uniformly varied from cube to cube. Each irradiated cube was exposed with the dose of 1013 X-ray photons. The calibration of this dose in the radiological units (Gy) was carried out using the tissue-equivalent thermoluminescent detectors (TLD-800). The corresponding exposition dose was estimated as 30 kGy for each cube. The radiation effects were evaluated by Raman spectroscopy and by morphological changes observed with the raster electron microscope. The primary radiation effect appears in the essential increase of the polymerization degree with consuming carbon-carbon double bonds in favor of the polymer cross-linking. Only one cube of 6 has changed the size and shape due to this effect, while the others retained the initial shape. Morphological changes are connected with the improper fabrication parameters (laser power and slicing step). Properly fabricated objects withstand the X-rays of the synchrotron radiation beam.