: Received: 18 January 2020 / Approved: 20 January 2020 / Online: 20 January 2020 (03:04:23 CET)
: Received: 8 February 2020 / Approved: 10 February 2020 / Online: 10 February 2020 (10:45:23 CET)
Cosper, P.F.; Abel, L.; Lee, Y.-S.; Paz, C.; Kaushik, S.; Nickel, K.P.; Alexandridis, R.; Scott, J.G.; Bruce, J.Y.; Kimple, R.J. Patient Derived Models to Study Head and Neck Cancer Radiation Response. Cancers2020, 12, 419.
Cosper, P.F.; Abel, L.; Lee, Y.-S.; Paz, C.; Kaushik, S.; Nickel, K.P.; Alexandridis, R.; Scott, J.G.; Bruce, J.Y.; Kimple, R.J. Patient Derived Models to Study Head and Neck Cancer Radiation Response. Cancers 2020, 12, 419.
Patient derived model systems are important tools for studying novel anti-cancer therapies. Patient derived xenografts (PDXs) have gained favor over the last 10 years as newer mouse strains have improved the success rate of establishing PDXs from patient biopsies. PDXs can be engrafted from head and neck cancer (HNC) samples across a wide range of cancer stages, retain the genetic features of their human source, and can be treated with both chemotherapy and radiation, allowing for clinically relevant studies. Not only do PDXs allow for study of patient tissues in an in vivo model, they can also provide a renewable source of cancer cells for organoid cultures. Herein, we review the uses of HNC patient derived models for radiation research including approaches to establishing both orthotopic and heterotopic PDXs, approaches and potential pitfalls to delivering chemotherapy and radiation to these animal models, biological advantages and limitations, and alternatives to animal studies that still use patient-derived tissues.
head and neck cancer; radiation therapy; radiation; patient-derived models; cancer
MEDICINE & PHARMACOLOGY, Oncology & Oncogenics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.