Lansangan, C.; Khoobchandani, M.; Jain, R.; Rudensky, S.; Perry, C.C.; Patil, R. Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives. Materials2024, 17, 1153.
Lansangan, C.; Khoobchandani, M.; Jain, R.; Rudensky, S.; Perry, C.C.; Patil, R. Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives. Materials 2024, 17, 1153.
Lansangan, C.; Khoobchandani, M.; Jain, R.; Rudensky, S.; Perry, C.C.; Patil, R. Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives. Materials2024, 17, 1153.
Lansangan, C.; Khoobchandani, M.; Jain, R.; Rudensky, S.; Perry, C.C.; Patil, R. Designing Gold Nanoparticles for Precise Glioma Treatment: Challenges and Alternatives. Materials 2024, 17, 1153.
Abstract
Glioblastoma multiforme (GBM) is a glioma and the most aggressive type of brain tumor with a dismal average survival time, despite the standard of care. One promising alternative therapy is boron neutron capture therapy (BNCT), which is a noninvasive therapy for treating locally invasive malignant tumors, including glioma. BNCT involves boron-10-released radiation directly into tumor cells with minimal damage to healthy tissues. This therapy lacks clinically approved targeted blood-brain-barrier-permeating delivery vehicles for therapeutic drug/ boron-10. Nanoparticles, particularly gold nanoparticles (GNPs), are selective and effective drug-delivery vehicles because of their desirable properties, facile synthesis, and biocompatibility. This review discusses historical and current GNP therapeutic applications as a drug delivery vehicle for treating glioma. Furthermore, GNPs loaded with therapeutic drugs, imaging agents, and GBM-targeting antibodies/ peptides to treat GBM will be discussed. Additionally, the importance of upper and lower limits on therapeutic efficacy will be described and explored followed by highlighting their advantages, limitations, and possible toxicity. Recent research and selected important findings for GNP-mediated pharmaceutics in GBM will also be considered.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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