Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Radiation-Induced Undifferentiated Spindle Cell Sarcoma Following High-Dose-Rate Interstitial Brachytherapy for Tongue Squamous Cell Carcinoma

Yuka Uchimoto
,
Hiroaki Shimamoto
* ORCID logo ,
Ami Takeshita
,
Kaori Oya
,
Mitsunobu Kishino
,
Yasuo Fukuda
,
Satoru Toyosawa
,
MIchio Oda
,
Kazuhiko Ogawa
,
Sven Kreiborg
,
Sanjay M. Mallya
,
Shumei Murakami
Version 1 : Received: 28 February 2022 / Approved: 1 March 2022 / Online: 1 March 2022 (09:53:27 CET)

How to cite: Uchimoto, Y.; Shimamoto, H.; Takeshita, A.; Oya, K.; Kishino, M.; Fukuda, Y.; Toyosawa, S.; Oda, M.; Ogawa, K.; Kreiborg, S.; Mallya, S.M.; Murakami, S. Radiation-Induced Undifferentiated Spindle Cell Sarcoma Following High-Dose-Rate Interstitial Brachytherapy for Tongue Squamous Cell Carcinoma. Preprints 2022, 2022030013. https://doi.org/10.20944/preprints202203.0013.v1 Uchimoto, Y.; Shimamoto, H.; Takeshita, A.; Oya, K.; Kishino, M.; Fukuda, Y.; Toyosawa, S.; Oda, M.; Ogawa, K.; Kreiborg, S.; Mallya, S.M.; Murakami, S. Radiation-Induced Undifferentiated Spindle Cell Sarcoma Following High-Dose-Rate Interstitial Brachytherapy for Tongue Squamous Cell Carcinoma. Preprints 2022, 2022030013. https://doi.org/10.20944/preprints202203.0013.v1

Abstract

Abstract: High-dose-rate interstitial brachytherapy (HDR-ISBT) has recently come to be considered one of the most effective treatments for oral cancer. On the other hand, it is important to note that radiation therapy has some side effects. Especially, radiation-induced malignancy is probably the most serious complication affecting long-term survivors. We report a case of a radiation-induced undifferentiated spindle cell sarcoma that developed following HDR-ISBT for tongue squamous cell carcinoma (SCC). A 39-year-old woman with right tongue SCC underwent HDR-ISBT (60 Gy, 10 fractions, 8 days) treatment. Five years and one month later, a tumor had developed at the primary site. Surgery was performed for the tumor, which was histopathologically diagnosed as an undifferentiated spindle cell sarcoma. That was distinct from the squamous cell origin of the primary cancer. According to recently established criteria for radiation-induced malignancy, this case was classified as a radiation-induced sarcoma. A search of the literature revealed no previous report of radiation-induced malignancy following HDR-ISBT for tongue cancer.

Keywords

radiation-induced; sarcoma; brachytherapy; tongue

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.