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Preprint ARTICLE | doi:10.20944/preprints201805.0296.v1

Some Normal Intuitionistic Fuzzy Heronian Mean Operators Using Hamacher Operation and Their Application

Guofang Zhang, Zhiming Zhang, Hang Kong

Subject: Computer Science And Mathematics, Computer Science Keywords: normal intuitionistic fuzzy numbers; Heronian mean; Hamacher t-conorm; Hamacher t-norm

Online: 22 May 2018 (10:15:21 CEST)

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Hamacher operation which is generalization of the Algebraic and Einstein operation, can widely provide a large number of arithmetical operation with respect to uncertainty information, and Heronian mean can deal with correlations of the input arguments or different criteria and don’t make calculation redundancy, meanwhile, the normal intuitionistic fuzzy numbers (NIFNs) can depict distinctively normal distribution information in practical decision making. In this paper, a multi-criteria group decision-making (MCGDM) problem is researched under the NIFNs environment, and a new MCGDM approach is introduced on the basis of the Hamacher operation. Firstly, according to Hamacher t-conorm and t-norm, some operational laws of NIFNs are presented. Secondly, it is noticed that Heronian mean can’t only once take into account mutual relation between attribute values once, but also consider the correlation between input argument and itself. Therefore, we develop some operators and study their properties in order to aggregate normal intuitionistic fuzzy numbers information, these operators include Hamacher Heronian mean (NIFHHM), Hamacher weighted Heronian mean (NIFHWHM), Hamacher geometric Heronian mean (NIFHGHM) and Hamacher weighted geometric Heronian mean (NIFHWGHM). Furthermore, we apply the proposed operators to the MCGDM problem and present a new method. The main characteristics of this new method involve that: (1) it is suitable to make decision under the normal intuitionistic fuzzy numbers environment and more reliable and reasonable to aggregate the normal distribution information. (2) it utilizes Hamacher operation which can provide more reliable and flexible decision-making results and offer an effective and powerful mathematic tool for the MAGDM under uncertainty. (3) it uses the Heronian mean operator which can considers relationships between the input arguments or the attributes and don’t brings subsequently about redundancy. Lastly, an application is given for showing the feasibility and effectiveness of the presented method in this paper.

Preprint ARTICLE | doi:10.20944/preprints201710.0120.v1

Normal Approximations of the Arithmetic of Mixed Fuzzy Numbers

Yi-Fang Chen, Hui-Chin Tang

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: fuzzy number; normal fuzzy number; addition and subtraction; approximation.

Online: 17 October 2017 (14:24:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0416.v1

An Observation on Distribution of Prime Numbers

Dariush Bahrami

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Prime Number; Prime Numbers Distribution; Prime Number Generation; Normal Distribution

Online: 15 June 2021 (15:58:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0361.v1

Guideline on Returning to Work after COVID-19 Infection

Mikhael Yosia, Nuri Purwito Adi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; occupational health; new normal

Online: 13 April 2021 (14:33:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0259.v1

Investigation of Propane and n- butane Hydrate Formation Condition and Determination of Equilibrium Pressure

Somayeh Salehfekr, Sajjad Porgar, Nejat Rahmanian

Subject: Physical Sciences, Chemical Physics Keywords: hydrate; propane; normal butane; equilibrium pressure

Online: 19 December 2019 (13:10:12 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202009.0683.v1

A Novel DNA Extraction Protocol from Frozen Blood of Normal Individuals and Patients Who Received Systemic Chemotherapy

Hayder O. Hashim, Mohammed Baqur S. Al-Shuhaib

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: DNA extraction; normal; patients; protocol; frozen blood

Online: 28 September 2020 (10:52:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0485.v1

Thermal Fluctuations of Torus-like Charge AdS Black Hole

R. H. Ali, G. Abbas

Subject: Physical Sciences, Thermodynamics Keywords: Thermodynamics; Thermal fluctuation; Phase transition and Quasi normal modes

Online: 28 March 2023 (10:27:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0251.v1

The impact of BMI on Ovarian Cancer- An Updated Systematic Review and Metanalysis

Nikolaos Tzenios, Mary Tazanios, Mohamed Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ovarian cancer; BMI; obesity; overweight; normal weight; statistical significance

Online: 14 November 2022 (09:57:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0462.v1

Newton’s Like Normal S-iteration under Weak Conditions

Manoj Kumar Singh, Ioannis K. Argyros, Arvind K. Singh

Subject: Computer Science And Mathematics, Mathematics Keywords: Newton’s method; normal S-iteration; weak condition; simple root

Online: 31 October 2022 (02:23:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0666.v1

A Re-Evaluation of the Swiss Hail Suppression Experiment using Permutation Techniques shows Enhancement of Hail Energies when Seeding

Armin Auf der Maur, Urs Germann

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: hail prevention; non-normal distributions; permutation; bootstrap; confidence intervals

Online: 29 July 2021 (14:21:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0559.v1

Normal Bases on Galois Ring Extensions

Zhang Aixian, Feng Keqin

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Galois ring; optimal normal basis; multiplicative complexity; finite field

Online: 28 September 2018 (09:41:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0084.v1

Estimation of Missing Streamflow Data Using Anfis Models and Determination of the Number of Datasets for Anfis: The Case of Yeşilırmak River

Kemal Saplioglu, Tulay Sugra Kucukerdem

Subject: Engineering, Civil Engineering Keywords: anfis; missing data; multiple regression; normal ratio method; Yeşilırmak

Online: 12 March 2018 (07:00:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0098.v1

Analysis of Confirmatory Auditory Responses in Unilateral Tinnitus Patients with Normal Hearing

Yong Jun Jeong, Kyoung Ho Oh, Sung Jin Lim, Dong Heun Park, Yoon Chan Rah, June Choi

Subject: Medicine And Pharmacology, Otolaryngology Keywords: tinnitus; normal hearing; Evoked potentials; auditory; brain stem; otoacoustic emission

Online: 6 July 2022 (13:54:44 CEST)

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In patients with unilateral tinnitus with normal hearing, several studies have compared the ipsilateral and contralateral ears; however, few studies have investigated its relationship with the duration of tinnitus. We compared the auditory brainstem response and otoacoustic emission parameters between ipsilateral and contralateral ears in adults with unilateral tinnitus and normal hearing. This retrospective review included 84 patients with unilateral tinnitus and normal hearing who underwent auditory brainstem response and otoacoustic emission; they were categorized according to the duration of tinnitus. The latencies and amplitudes of waves I, III, and V, and V/I ratio of both ears in auditory brainstem response, and the results of distortion-product otoacoustic emission and transient evoked otoacoustic emission were examined. The auditory brainstem response parameters, distortion-product otoacoustic emission parameters, and transient evoked otoacoustic emission parameters between the ipsilateral and contralateral ears along the duration of tinnitus were analyzed. Moreover, the failure rates of both distortion-product otoacoustic emission and transient evoked otoacoustic emission between the ears along with the duration and the effects of the variables on the amplitude and latency of each wave were examined. Although there was little significant difference between the ipsilateral and contralateral ears, laterality seemed to have an effect on wave I latency in the multiple linear regression analysis. The distortion-product otoacoustic emission failure rate of the ipsilateral ear was higher than that of the contralateral ear in all patients. However, there was no remarkable difference between the ears in the distortion-product otoacoustic emission and transient evoked otoacoustic emission parameters throughout the duration. We found that outer hair cells and the distal portion of the cochlear nerve are possible pathologic lesions in tinnitus with normal hearing and cochlear synaptopathy could be suspected. Further studies, including those on inner hair cells and higher central cortex, are needed.

Preprint ARTICLE | doi:10.20944/preprints202111.0274.v1

Rayleigh–Bénard Instability of an Ellis Fluid Saturated Porous Channel with an Isoflux Boundary

Pedro Vayssière Brandão, Michele Celli, Antonio Barletta

Subject: Engineering, Mechanical Engineering Keywords: Ellis fluid; Porous medium; Normal modes; Rayleigh–Bénard instability; Convection.

Online: 15 November 2021 (19:39:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0503.v1

Gröbner-Shirshov Bases Theory for Trialgebras

Juwei Huang, Yuqun Chen

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Gröbner-Shirshov basis; normal form; Gelfand-Kirillov dimension; trialgebra; trisemigroup

Online: 19 April 2021 (15:19:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints201902.0238.v1

The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

Maria Matyska, Joseph Pesek

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: hydride surface; silicon-carbon bond; aqueous normal phase; retention mechanism

Online: 26 February 2019 (11:33:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1670.v1

Effect of Diffusion and Laser Pulse on a Poro-Thermoelastic Medium via Three-Phase-Lag Model

Mohamed Abdelsabour Fahmy, Mohamed I. A. Othman, Elsayed M. Abd-Elaziz

Subject: Engineering, Mechanical Engineering Keywords: Three-phase-lag model; Laser pulse; Diffusion; Voids; Normal mode analysis

Online: 24 May 2023 (02:39:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0148.v1

Normal Calculus on Moving Surfaces

Keith C. Afas

Subject: Computer Science And Mathematics, Mathematics Keywords: calculus of moving surfaces; CMS; differential geometry; normal; tensor; hypersurfaces; dynamic

Online: 11 June 2018 (09:54:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0535.v1

On the ROC Area of Ensemble Forecasts for Rare Events

Zied Ben Bouallegue, David S. Richardson

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: ROC area; discrimination; verification artefacts; trapezoidal approximation; bi-normal model; imprecise probability

Online: 29 November 2021 (12:36:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0359.v2

Factors Affecting Customer Satisfaction & Loyalty in Online Food Delivery Service during COVID-19 Pandemic: Its Relation with Open Innovation

Yogi Tri Prasetyo, Hans Tanto, Martinus Mariyanto, Christopher Hanjaya, Michael Nayat Young, Satria Fadil Persada, Bobby Ardiansyah Miraja, A.A.N. Perwira Redi

Subject: Engineering, Automotive Engineering Keywords: food delivery; customer satisfaction; new normal; COVID-19; theory of planned behavior

Online: 19 February 2021 (10:01:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0130.v1

A Novel Treatment of the Josephson Effect

Jacob Szeftel, Nicolas Sandeau, Michel Abou Ganthous

Subject: Physical Sciences, Acoustics Keywords: Josephson effect; transport properties; critical current; tunnelling; superconducting-normal transition; negative resistance

Online: 4 February 2021 (10:01:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0065.v1

Social-Ecological Experiments to Foster Agroecological Transition

Sabrina Gaba, Vincent Bretagnolle

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: agroecology; biodiversity; ecosystem services; post-normal science; socio-ecological systems; sustainability; stakeholders

Online: 6 May 2019 (12:28:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0121.v1

Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery

Marieke A. Stammes, Hendrica A. J. M. Prevoo, Meyke C. Ter Horst, Stéphanie A. Groot, Cornelis J. H. Van De Velde, Alan B. Chan, Lioe-Fee De Geus-Oei, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Elena B. Pasquale, Cornelis F. M. Sier

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tissue microarray; immunohistochemistry; cancer imaging; tyrosine kinase receptor; normal tissue; colon cancer

Online: 24 November 2016 (11:07:23 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202203.0166.v1

A Note on Novel Normal-Power Non-Linear Function

Matthew Iwada Ekum

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Bimodal Dependent Variable; Normal-Power; Non-Linear; Least Square Estimation; Economy-Tourism Model

Online: 11 March 2022 (10:07:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0252.v1

Fundamentally Good Alternative to Normal Distribution

Kabir Bindawa Abdullahi

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: alternative parameterization; normal distribution; dispersion estimators; location-invariance; scale-invariance; scale-and-location-invariance

Online: 19 September 2022 (02:06:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0145.v2

Rényi Entropy Power Inequalities via Normal Transport and Rotation

Olivier Rioul

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Rényi entropy; entropy power inequalities; transportation arguments; normal distributions; escort distributions; log-concave distributions

Online: 23 August 2018 (04:24:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0562.v1

Intra-Articular Facet Joint Injection of Normal Saline for Chronic Low Back Pain: A Systematic Review and Meta-Analysis

Areerat Suputtitada, Tanawin Nopsopon, Thanitsara Rittiphairoj, KRIT Pongpirul

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Facet joint injection; Chronic low back pain; Normal saline; Meta-analysis; Patient Reported Clinical Outcomes

Online: 9 May 2023 (04:22:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0157.v1

Stress Tensor and Gradient of Hydrostatic Pressure in the Contact Plane of Axisymmetric Bodies Under Normal and Tangential Loading

Emanuel Willert, Fabian Forsbach, Valentin L. Popov

Subject: Engineering, Mechanical Engineering Keywords: stress state; pressure gradient; normal contact; tangential contact; friction; axial symmetry; method of dimensionality reduction

Online: 10 March 2020 (03:22:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0133.v1

AC Dielectric Strength of Mineral Oil-Based Fe₃O₄ and Al₂O₃ Nanofluids

Usama Khaled, Abderrahmane Beroual

Subject: Engineering, Electrical And Electronic Engineering Keywords: AC dielectric strength; insulating oils; mineral oil-based nanofluids; statistical analysis; Weibull distribution; normal distribution

Online: 6 November 2018 (10:20:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1144.v1

Collagen Hydrolysate Effects on Photodynamic Efficiency of Gallium(III) Phthalocyanine on Pigmented Melanoma Cells

Vanya Mantareva, Ivan Iliev, Inna Sulikovska, Mahmut Durmus, Tsanislava Genova

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: bovine collagen hydrolysate; gallium phthalocyanine; pigmented melanoma; normal keratocytes and fibroblasts; mouse embryonal fibroblasts; photodynamic therapy

Online: 16 May 2023 (09:46:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0292.v1

Blood Pressure Correlates with Serum Leptin and Body Mass index in Overweight Male Saudi Students

Shalan Alaamri, Abdulhalim S. Serafi, Zahir Hussain, Munira M. Alrooqi, Mohammed A. Bafail, Sumera Sohail

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: systolic blood pressure; diastolic blood pressure; serum leptin; body mass index; normal and overweight male students

Online: 13 April 2023 (03:41:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0452.v1

Idiopathic Normal Pressure Hydrocephalus Diagnosis: Quantitative and Qualitative Score Predicting Outcome of Extended Lumbar Drainage

Maria Caffo, Roberta Laera, Maria Luisa Gorgoglione, Antonello Curcio, Giuseppina Marzano, Gerardo Caruso, Antonino Germanò

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Extended lumbar drainage; Hydrocephalus; Idiopathic normal pressure hydrocephalus; neurodegenerative diseases; Qualitative neurocognitive tests; Quantitative neurocognitive tests

Online: 23 December 2022 (08:09:41 CET)

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Background: Idiopathic normal pressure hydrocephalus is a syndrome with neuroradiological findings and clinical pattern characteristic but not specific for the pathology. Since the prevalence is growing due to the rapidly aging society, standardized and validated protocol for diagnosis is needed, also because this condition may mimic other disorders among elderly such as Parkinson's and Alzheimer's disease. Material and methods: We analysed data from 44 patients with suspect diagnosis of idiopathic normal pressure hydrocephalus with age > 60 years, clinical triad and neuroradiological pattern examined in our ward from November 2018 to November 2022. Neu-ropsychological assessment includes Mini Mental State Examination and Mental Deterioration Battery. Motor scores were collected from gait and balance tests. The evaluation was performed before and after an extended lumbar drainage last 48h. Patients who has scores improvement after the extended lumbar drainage, undergo ventriculoperitoneal shunt with a programmable valve. Results: All patients undergo neuropsychological assessment and motor tests, only 2 patients were unable to perform motor tests because bedridden. 16 patients showed no benefit from the tests, in 2 cases even a worsening of cognitive performance. 28 patients showed an improvement in their performances, but in most cases the improvement involved only the neuropsychological as-sessment. All patients underwent ventriculoperitoneal shunt have had a typical answers pattern in Mental Deterioration Battery test. We performed 9 ventriculoperitoneal shunt and 1 ventricu-lo-atrial shunt. Conclusions: Qualitative neurocognitive tests come out to be more sensitive compared to quantitative neurocognitive tests in identifying patients with suspected idiopathic normal pressure hydrocephalus benefiting from extended lumbar drainage test and then un-derwent surgical treatment. This could be considered a valid screening in elderly patients with suspected idiopathic normal pressure hydrocephalus in order to minimize the number of invasive procedures. More studies are necessary to validate this tool.

Preprint REVIEW | doi:10.20944/preprints202203.0309.v1

Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma

Frances Byrne, Ellen Olzomer, Nina Lolies, Kyle Lee Hoehn, Marthe-Susanna Wegner

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: glycolysis; GEMs; oxidative phosphorylation; UGCG; glucosylceramide; normal liver cells; gangliosides; lacto/neo-lacto series GSLs; sulfatides

Online: 23 March 2022 (04:39:25 CET)

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Working Paper ARTICLE

Recognition of Potential COVID-19 Drug Treatments Through the Study of Existing Protein-Drug and Protein-Protein Structures: An Analysis of Kinetically Active Residues

Ognjen Perišić

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Covid-19; proteins; normal-modes; protein-drug interactions; chloroquine; ivermectin; remdesivir; sofosbuvir; boceprevir; α-difluoromethylornithine (DMFO)

Online: 11 August 2020 (04:09:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0307.v1

Edge-based Color Image Segmentation using Particle Motion on Vector Fields Derived from Local Color Distance Images

Wutthichai Phornphatcharaphong, Nawapak Eua-Anant

Subject: Computer Science And Mathematics, Computer Science Keywords: Color images segmentation; Particle Motion; Local Color Distance Images; Normal compressive vector field; Edge vector field

Online: 14 July 2020 (12:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0069.v1

Testing Ststistical Hypothesis in Light of Mathematical Aspects in Analysis of Probability

Michael Fundator

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Principal of prediction; random sequences; recurrence; Law of Large Numbers; exponential; normal; bivariate; distribution; Entropy; Information

Online: 23 July 2016 (09:25:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0098.v1

Dirichlet Process Log Skew-normal Mixture with Missing at Random Covariate in Insurance Claim Analysis

Minkun Kim, David Lindberg, Martin Crane, Marija Bezbradica

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Bayesian nonparametric model; heterogeneity; missing at random; log-normal sum approximation; aggregate insurance claims; clustering; generative model

Online: 1 June 2023 (13:47:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0474.v1

Delicate Comparison of the Central and Non-central Lyapunov Ratios with Applications to the Berry–Esseen Inequality for Compound Poisson Distributions

Vladimir Makarenko, Irina Shevtsova

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Lyapunov fraction; extreme problem, moment inequality; central limit theorem; Berry–Esseen inequality; compound Poisson distribution; normal approximation

Online: 26 December 2022 (06:43:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0074.v1

Isochoric Specific Heat in the Dual Model of Liquids

Fabio Peluso

Subject: Physical Sciences, Condensed Matter Physics Keywords: Liquid model; Phonons in liquids; Instantaneous Normal Modes; Mesoscopic model of liquids; Phonon – particle interaction; Specific heat

Online: 3 November 2021 (09:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0532.v3

Examining the Role of the Noradrenergic Locus Coeruleus for 2 Predicting Attention and Brain Maintenance in Healthy Old Age 3 and Disease: An MRI Structural Study for the Alzheimer’s Disease 4 Neuroimaging Initiative

Emanuele Raffaele Giuliano Plini, Erik O'Hanlon, Rory Boyle, Francesca Sibilia, Gaia Rikhye, Joanne Kenney, Robert Whelan, Michael Christopher Melnychuk, Ian Hamilton Robertson, Paul Michael Dockree

Subject: Social Sciences, Psychology Keywords: Locus Coeruleus; Reserve; Brain Age; Visual Attention; Alzheimer’s Disease; Mild Cognitive Impairment; normal Aging; Neuroimaging; Voxel Based Morphometry

Online: 21 June 2021 (11:41:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0504.v1

The Videofluorographic Swallowing Study: A Review of Literature

Umar Farooque, Syed Adeel Hassan, SM Ismail Shah, Saba Asif, Muhammad Humayoun Rashid, Abubakar Tauseef

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dysphagia; swallowing impairment; videofluorographic swallowing study; literature review; procedures; indications; normal and critical findings; interfering factors; complications; clinical significance

Online: 21 December 2020 (10:55:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0065.v1

Dielectric Properties of Aqueous Solutions at Normal and High Dilutions

Sergey Vladimirovich Savel’ev, Ludmila Arkad’evna Morozova

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: radiothermal signals; radiobrightness temperature; normal and high dilution solutions; absorption coefficient; ion hydration shell; new dielectric properties; supramolecular interactions; dispersion

Online: 3 March 2022 (13:52:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0368.v1

Evaluation of Combined Use of Drought Indices in the Case of Konya Closed Basin

Huseyin Yildirim Dalkilic

Subject: Engineering, Civil Engineering Keywords: Aridity Index (AI); Percentage of Normal Index (PNI); Standardized Precipitation -Evopotranspiration Index (SPEI); Standardized Precipitation Index (SPI); Drought; Factor Analysis; Reliability Analysis

Online: 25 February 2020 (11:09:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0043.v1

Bayesian Hierarchical Scale Mixtures of Log-Normal Models for Inference in Reliability with Stochastic Constraint

Hea-Jung Kim

Subject: Computer Science And Mathematics, Information Systems Keywords: Bayesian reliability analysis; Bayesian hierarchical model; MCMC method; scale mixtures of log-normal failure time model; stochastic constraint; two-stage MaxEnt prior.

Online: 4 May 2017 (16:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0091.v1

Fisetin a 3, 7, 3′, 4′-Tetrahydroxyflavone Inhibits PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

Jean Christopher Chamcheu, Stephane Esnault, Vaqar M. Adhami, Andrea L. Noll, Sergette Banang-Mbeumi, Tithi Roy, Sitanshu S. Singh, Shile Huang, Konstantin Gus Kousoulas, Hasan Mukhtar

Subject: Medicine And Pharmacology, Dermatology Keywords: fisetin; psoriasis; normal human epidermal keratinocyte; cell signaling; cell differentiation; proliferation; inflammatory cytokine; PBMC; CD4+ T lymphocyte; 3D psoriasis-like skin disease model

Online: 9 September 2019 (07:48:26 CEST)

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Psoriasis is a chronic immune-mediated skin disease that involves interaction of both immune and skin cells, and is characterized by cytokine-driven epidermal hyperplasia, deviant differentiation, inflammation and angiogenesis. Because available treatments for psoriasis have significant limitations, dietary products are potential natural sources of therapeutic molecules, which can rescind molecular defects associated with psoriasis and could be developed for its management. Fisetin (3,7,3′,4′- tetrahydroxyflavone), a phytochemical naturally found in pigmented fruits and vegetables has demonstrated pro-apoptotic and antioxidant effects in several malignancies. This study utilized biochemical, cellular, pharmacological and tissue-engineering tools to characterize the effects of fisetin on normal human epidermal keratinocytes (NHEKs), peripheral blood mononuclear cells (PBMC) and CD4+ T lymphocytes in 2D and 3D psoriasis-like disease models. Fisetin treatment of NHEKs dose and time-dependently induced differentiation and inhibited interleukin-22-induced proliferation, as well as activation of the PI3K/Akt/mTOR pathway. Fisetin treatment of TNF-α-stimulated NHEKs significantly inhibited the activation of p38 and JNK, but had no effect on ERK1/2. In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFNγ and IL-17A by 12-O- tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs. Furthermore, we established the in-vivo relevance of fisetin functions, using a 3D full-thickness human skin model of psoriasis (FTRHSP) that closely mimics in-vivo human psoriatic skin-lesions. Herein, fisetin significantly ameliorated psoriasis-like disease features, and decreased the production of IL-17 by CD4+ T lymphocytes co-cultured with FTRHSP. Collectively, our data identify pro-differentiative, anti-proliferative and anti-inflammatory effects of fisetin, via modulation of PI3K-Akt-mTOR and p38/JNK pathways and the production of cytokines in 2D and 3D human skin model of psoriasis. These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis and other related inflammatory skin disorders.

Preprint ARTICLE | doi:10.20944/preprints202108.0272.v1

Remaining Useful Life Prediction from 3D Scan Data with Genetically Optimized Convolutional Neural Networks

Giovanni Diraco, Pietro Siciliano, Alessandro Leone

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Remaining Useful Life; Deep Neural Network; Convolutional Neural Network; Genetic Optimization; Neural Network Optimization; Support Vector Regression; Depth Maps; Normal Maps; 3D Point Clouds.

Online: 12 August 2021 (10:40:23 CEST)

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