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Preprint REVIEW | doi:10.20944/preprints202305.1680.v1

Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Vincenzo Losappio, Infante Barbara, Annamaria Maiorano, Serena Simiele, Sara Rosato, Silvia Mercuri, Dario Troise, Giovanni Stallone, Paola Pontrelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Chronic kidney disease; Pentraxin-3; Renal Replacement Therapies; Inflammaging.; innate immunity

Online: 24 May 2023 (03:59:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1671.v1

Comparison of Portable Oxygen Concentrators and Inspired Oxygen Levels Using a COPD Patient Simulation Model

Douglas S. S Gardenhire, Robert B Murray, Robin E Gardenhire, Kyle Brandenberger

Subject: Public Health And Healthcare, Other Keywords: portable oxygen concentrators; chronic obstructive pulmonary disease; home oxygen therapy; respiratory care; oxygen therapy; obstructive lung disease

Online: 24 May 2023 (02:44:53 CEST)

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Background: Portable oxygen concentrators (POCs) have shown efficacy in delivering adequate oxygen for various patient scenarios; however, there is a lack of research on POCs’ efficacy across different respiratory rates specifically among COPD patients. Methods: This bench study was conducted using the IngMar Medical Active Servo Lung 5000 attached to flexible tubing, which simulated an adult patient’s nares. An oxygen analyzer (Maxtec Handi+) was connected to the tubing 6 inches below the nares to estimate the inspired oxygen concentration at the adult trachea. A standard nasal cannula was placed in the simulated patient nares, which was also attached to each POC. The IngMar Lung was programmed to simulate a COPD patient at the following respiratory rates: 15, 20, 30, and 40 breaths/min. POC devices were then compared to an oxygen wall outlet and a standard oxygen concentrator (non-portable CAIRE device). The POCs included the CAIRE FreeStyle Comfort (with Autosat), CAIRE FreeStyle Comfort (without Autosat), Inogen G4, Inogen G5, Phillips SimplyGo Mini, GCE Zen-O lite, Drive Medical iGo2, and Kingon POCs. Descriptive statistics and ANOVAs were computed to determine statistically significant differences between POCS and control devices (wall oxygen and standalone oxygen concentrator). Results: Across most respiratory rate scenarios, the wall oxygen and standalone oxygen concentrator (control group) resulted higher oxygen measurements compared to the POCs. Among the POCs on setting 2, the highest oxygen measurement for 15, 30, and 40 breaths/min was the CAIRE FreeStyle Comfort with AutoSat on sensitivity 5 (24.43%, 24.81%, and 25.0%, respectively). On setting 2, the 20 breaths/min highest oxygen measurement was the Inogen G4 (24.43%). For setting 5, the highest oxygen measurement for 15 breaths/min and 40 breaths/min was the CAIRE FreeStyle Comfort without AutoSat (31.56% and 26.13%, respectively), while the highest oxygen measurement for 20 breaths/min was the Inogen G5 (30.26%), and the highest oxygen measurement for 30 breaths/min was the CAIRE FreeStyle Comfort with AutoSat on sensitivity level 5 (27.89%). Conclusions: The oxygen administered through the wall and the standalone CAIRE oxygen concentrator all delivered higher oxygen levels compared to the POCs (with the exception of the 40 breaths/min scenario on setting 2). However, among the POCs, the CAIRE Freestyle Comfort with AutoSat, CAIRE Freestyle Comfort without AutoSat, and the Inogen G4 all performed the best among the various breathing rate scenarios.

Preprint REVIEW | doi:10.20944/preprints202304.0843.v2

Zanubrutinib: Coming of Age for BTK Inhibitors in the Treatment of Chronic Lymphocytic Leukemia?

Stefano Molica, Constantine Tam, David Allsup, Aaron Polliack

Subject: Medicine And Pharmacology, Hematology Keywords: CLL, Zanubrutinib, BTK inhibitors, efficacy, safety, chronic lymphocytic leukemia

Online: 22 May 2023 (16:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0475.v2

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Tatiane Lobato Da Silva, Apio Ricardo Nazareth Dias, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis C virus; Genetic; Chronic Hepatitis C; Liver; Elastography

Online: 22 May 2023 (13:56:53 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.1381.v1

Chronic Viral Hepatitis in Children: Socio-Economic Implications in Romania

Irina Dijmărescu, Alexandra Coroleuca, Adrian Dumitru Dijmarescu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic viral hepatitis; socio-economic status; children

Online: 19 May 2023 (05:07:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1254.v1

The Association of Oxidative Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits

Ema Vrbanović, Marko Zlendić, Koraljka Gall Trošelj, Marko Tomljanović, Kristina Vuković Đerfi, Iva Zilic-Alajbeg

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: antioxidants; chronic orofacial pain; oxidative-stress related genes; temporomandibular disorders; oral behavioural habits; single nucleotide polymorphism

Online: 17 May 2023 (14:15:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1242.v1

Undernutrition Modifies the Antihypertensive and Metabolic Responses of Rostafuroxin in Male Rats: Outcomes on Bodily Na⁺ Handling and Renal Na⁺-transporting ATPases

Amaury Pereira-Acácio, João P.M. Veloso-Santos, João P.M. Veloso-Santos, Glória Costa-Sarmento, Humberto Muzi-Filho, Adalberto Vieyra

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: rostafuroxin; arterial hypertension; chronic undernutrition; Regional Basic Diet; sodium and water balance; renal Na+-transporting ATPases

Online: 17 May 2023 (10:58:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1171.v1

Topical Application of Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation

Benedetta Ragghianti, Bianca Maria Berardi, Edoardo Mannucci, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Small Artery Disease; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 17 May 2023 (02:41:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0732.v1

Chronic Bacterial Airways disease: the Pernicious Global Health Challenge Hidden in Plain Sight

Mark L. Everard

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: chronic bacterial broncitis; airways disease; biofilms; microbiome; COPD; bronchiectasis

Online: 10 May 2023 (10:13:54 CEST)

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This manuscript is aimed at encouraging those interested in biofilms and their effects on microbial communities to view the study of chronic airways disease as one of the most challenging and potentially rewarding areas to focus on. To do this it is necessary to review how we have reached 2023 having made so little progress. It is more than two hundred years ago since the term bronchitis was proposed to describe diseases affecting the airways rather than the respiratory zone of the lungs. The main histological features were described in Laennec’s text of 1819. By the mid C20th it was recognised that the two great drivers of chronic respiratory symptoms were inhaled toxins and chronic bacterial infections. The widespread availability of antibiotics in subsequent years had a dramatic impact on mortality from pneumonia, greatly reduced the prevalence of chronic symptoms after acute lower respiratory tract infections, transformed the lives of many with bronchiectasis and appeared to play a major role in the dramatic fall in prevalence of bronchiectasis. Unfortunately, during the following 70 years the importance of dealing with a chronic bacterial bronchitis was largely forgotten. While two artificial diseases ‘COPD’ and ‘bronchiectasis’ have been the subject of numerous guidelines, chronic bacterial bronchitis has been out in the cold. Antibiotics have in theory been reserved for those with established damage in the form of bronchiolitis and impaired lung function as defined by an arbitrary FEV1/FVC ratio and even then there is a disconnect with a minimum of 2 weeks being prescribed for exacerbations of bronchiectasis and the use of long term inhaled and oral macrolides frequently being advocated while a 5 day course is reserved for an exacerbation in a patient with COPD. The loss of focus on the role of antibiotics has a number of causes – a desire to ration antibiotic as part of ‘antibiotic stewardship’, the potential cost of treatment, the failure to ‘cure’ patients with chronic bronchitis and the difficulty in dealing with a disease whose morbidity at any given time can range from a mild cough and production of phlegm in the morning with no obvious impact on daily function to troublesome cough, sputum production and significant ill health. This was compounded by the vagaries of culture based diagnosis and the observation that more than one potential pathogen was often present. As a result chronic bacterial bronchitis was relegated to the ‘too hard to deal with’ box and many of the lessons of the past were forgotten. Revisiting the field from the perspective of current understanding of bacterial behaviour in biofilms and how these alter the resident microbiota of the airways should ensure that a chronic bacterial bronchitis returns to centre stage in order to minimise respiratory morbidity and mortality. This review charts the history of our understanding and mis-understanding of the role of chronic bacterial bronchitis in airways disease and the pernicious effect of language in helping to ensure that this common and important condition became the elephant in the room. Focusing on the nature of chronic bacterial bronchitis is essential if we are to find ways of identifying it accurately and treat it effectively – new approaches will be extremely slow unless we recognise its importance and the challenges it poses.

Preprint REVIEW | doi:10.20944/preprints202305.0643.v1

Cells and Processes in Wound Healing: More Recent Advances

Montserrat Fernández-Guarino, María Luisa Hernández-Bule, Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: Acute Wounds; Cellular Infiltrate; Chronic Wounds; Keloids; Scars

Online: 9 May 2023 (11:06:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0580.v1

Prevalence of Clinical Signs and Symptoms of Temporomandibular Joint Disorders Registered in the EUROTMJ Database: A Prospective Study in a Portuguese Center

David Faustino Ângelo, Beatriz Mota, Ricardo São João, David Sanz, Henrique José Cardoso

Subject: Medicine And Pharmacology, Surgery Keywords: Temporomandibular joint disorders; parafunctional habits; risk factors; chronic diseases

Online: 9 May 2023 (07:10:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0562.v1

Intra-Articular Facet Joint Injection of Normal Saline for Chronic Low Back Pain: A Systematic Review and Meta-Analysis

Areerat Suputtitada, Tanawin Nopsopon, Thanitsara Rittiphairoj, KRIT Pongpirul

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Facet joint injection; Chronic low back pain; Normal saline; Meta-analysis; Patient Reported Clinical Outcomes

Online: 9 May 2023 (04:22:14 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0560.v1

Effects of Whole-Body Cryostimulation on pain management and disease activity in active Rheumatic Polymyalgia: a Case-Report

Federica Verme, Alessandra Scarpa, Giorgia Varallo, Paolo Piterà, Paolo Capodaglio, Jacopo Maria Fontana

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Polymyalgia Rheumatica; Whole-Body Cryostimulation; Chronic Pain; Disease Activity; Rehabilitation

Online: 9 May 2023 (04:17:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0483.v1

Causal Variables in the Association between Physical Well-Being and Chronic Pain: Results from a Cohort Study in Galicia (Northwest Spain)

Roya Karimi, Jesús Prego-Domínguez, Bahi Takkouche

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Chronic pain; confounding; interaction analysis; mediation analysis; physical well-being

Online: 8 May 2023 (08:50:51 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202305.0453.v1

Development of a Modified Global Physical Activity Questionnaire and its Construct Validity among Adults in Kerala, India

Thirunavukkarasu Sathish, Elezebeth Mathews

Subject: Public Health And Healthcare, Other Keywords: physical activity; GPAQ; validity; self-reports; chronic diseases

Online: 8 May 2023 (05:20:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0041.v1

A Significance of an Amelioration of Endothelial Dysfunction by Sodium-Glucose Cotransporter 2 Inhibitors for an Improvement of Heart Failure and Chronic Kidney Disease

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors

Online: 2 May 2023 (02:18:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1093.v1

Microglial Responses to Stress-Induced Depression: Causes and Consequences

Ruqayya Afridi, Kyoungho Suk

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines

Online: 28 April 2023 (03:28:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1087.v1

Renal Oxygen Demand and Nephron Function: Is Glucose a Friend or Foe?

Edoardo Gronda, Massimo Iacoviello, Alberto Palazzuoli, Manuela Benevenuto, Domenico Gabrielli, Arduino Arduini

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: glucose transport; SGLT2 inhibitor; diabetic nephropathy; heart failure; chronic kidney disease

Online: 28 April 2023 (03:08:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1063.v1

Empagliflozin Attenuates Vascular Calcification in Mice with Chronic Kidney Disease by Regulating the NFR2/HO-1 Anti-Inflammatory Pathway through AMPK Activation

Chia-Wen Lu, Chung-Jen Lee, Yi-Jen Hsieh, Bang-Gee Hsu

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: empagliflozin; vascular calcification; AMP-activated protein kinase; nuclear factor erythroid-2-related factor; heme oxygenase 1; chronic kidney disease

Online: 27 April 2023 (09:35:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0772.v1

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Roxana Darabont, Diana Mihalcea, Dragos Vinereanu

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: renal resistive index, acute and chronic kidney disease, arterial stiffness, cardiovascular disease

Online: 23 April 2023 (04:46:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0672.v1

Renal Biomarkers in Cardiovascular Patients with Acute Kidney Injury

Rolando Claure-Del Granado, Jonathan S. Chávez-Iñiguez

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Cardiorenal syndromes; Acute kidney injury; Biomarkers; Chronic kidney disease; Heart failure

Online: 21 April 2023 (05:26:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0491.v1

Towards an Artificial Intelligence Based Chronic Disease Management

William Alberto Cruz Castañeda, Pedro Bertemes Filho

Subject: Engineering, Electrical And Electronic Engineering Keywords: Smart Health; Internet of Medical Things; Healthcare 4.0; Chronic-Disease Management; Artificial Intelligence

Online: 18 April 2023 (05:20:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0319.v1

Recent Advances in Urinary Peptide and Proteomic Biomarkers in Chronic Kidney Disease: A Systematic Review

Lorenzo Catanese, Justyna Siwy, Harald Mischak, Ralph Wendt, Joachim Beige, Harald Rupprecht

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: biomarkers; chronic kidney disease; peptide; proteomic; urine

Online: 13 April 2023 (10:51:02 CEST)

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Background: Biomarker development, improvement, and clinical implementation in the context of kidney disease has been a central focus of biomedical research for decades. To this point, only serum creatinine and urinary albumin excretion are well accepted biomarkers in kidney disease. With their known blind spot in early stages of kidney impairment and diagnostic limitations there is a need for better and more specific biomarkers. With the rise of large-scale analysis of thousands of peptides in serum or urine samples using mass spectrometry techniques hopes for biomarker development were high. Advances in proteomic research have led to the discovery of an increasing amount of potential proteomic biomarkers and identification of candidate biomarkers for clinical implementation in the context of kidney disease management. In this review we focus on urinary peptide and especially peptidomic biomarkers emerging from recent research and underline the role of those with the highest potential for clinical implementation. Methods: The Web of Science database (all databases) was searched on October 17th, 2020, using the search terms “marker*” OR biomarker* AND “renal disease” OR “kidney disease” AND “proteome*” OR “peptid*” AND “urin*”. English, full-text original articles on humans published within the last 5 years were included which were cited at least 5 times per year. Studies based on animal models, renal transplant studies, metabolite studies, studies on miRNA and studies on exosomal vesicles were excluded focusing on urinary peptide biomarkers. Results: The described search led to the identification of 3668 articles and application of inclusion and exclusion criteria as well as abstract and consecutive full-text analysis of 3 independent authors to a final number of 62 studies for this manuscript. The 62 manuscripts encompassed 8 established single peptide biomarkers and several proteomic classifiers including CKD273 and IgAN237. Discussion: This review provides a summary of recent evidence on single peptide urinary biomarkers in CKD while emphasizing the increasing role of proteomic biomarker research with new research on established and new proteomic biomarkers. Lessons learned from the last 5 years in this review might encourage future studies hopefully resulting in routine clinical applicability of new biomarkers.

Preprint ARTICLE | doi:10.20944/preprints202304.0095.v1

Improving Quality of Life in Chronic Patients: A Pilot Study on the Effectiveness of a Health Recommender System and Its Usability

Alberto del Rio, Jennifer Jimenez, Rodrigo Medina-García, Cristina Lozano-Hernández, Federico Alvarez, Javier Serrano

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: health recommender system; recommender system; sensorial ecosystem; continuous monitoring; chronic diseases; integrated care; quality of life; elderly care

Online: 6 April 2023 (12:23:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0080.v1

Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian context using the GRADE-ADOLOPMENT methodology

Khalid Abdulaziz Alhasan, Juan José Yepes-Nuñez, Sumayah Askandarani, Yasser Sami Amer, Muneera Al-Jelaify, Khalid I. Almatham, Mohammed Al-Ghonaim, Sultan Al Dalbhi, Jameela Abdulaziz Kari, Ahmed Mitwalli, Ziad Memish, Joanna Sara Valson, Ximena Alvira, Khushnam Bilimoria, Ruchi Chawla, Sheila Feit, Skye Bickett, Klara Brunnhuber

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; antihypertensive; practice guidelines; recommendations; performance measures; GRADE; adolopment; AGREE II; RIGHT-Ad@pt; evidence-based healthcare; Saudi Arabia

Online: 6 April 2023 (08:59:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0078.v1

Personalizing Digital Health: Adapting Health Technology Systems to Meet the Needs of Different Older Populations

Jennifer Jimenez, Alberto del Rio, Arianna N. Berman, Miriam Grande

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging population; healthcare systems; healthcare system evaluation; chronic illness; digital healthcare; personalization; healthcare usability; healthcare satisfaction

Online: 6 April 2023 (08:48:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0549.v1

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Hiroyuki Ito, Takumi Matsuura, Tadashi Sano

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: beraprost; feline; chronic kidney disease; progression-free survival; overall survival

Online: 31 March 2023 (11:17:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0123.v2

Deciphering Pain in Vulnerable People with Chronic Conditions

Charlotte Faurie, Demi Cheng, Claire Duflos, Liset E.M. Elstgeest, Rosanna Ferreira, Hein Raat, Verushka Valsecchi, Alberto Pilotto, Graham Baker, Marta María Pisano-Gónzalez, Yves-Marie Pers

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; patient education; vulnerable populations; low income; quality of life

Online: 14 March 2023 (01:42:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0212.v1

An Audit of Geriatric Capacity Assessments Performed in a General Psychiatry Unit over a Decade

Eduard P. Drima MD

Subject: Social Sciences, Psychology Keywords: Geriatric decisional capacity assessment; wealth transfer; mild cognitive impairment; mild depression; neutrophils to lymphocytes ratio; chronic inflammation

Online: 13 March 2023 (04:10:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0085.v1

Mafosfamide combine with GMI-HBVac against HBV via Treg depletion in HBV-infected mice

Qing Lin, Yiwei Zhong, Bin Wang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic hepatitis B infection; Therapeutic vaccines; Regulatory T cells; Functional cure; GMI-HBVac; Mafosfamide

Online: 6 March 2023 (03:37:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0441.v1

Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)

Iris Viejo-Boyano, Luis Carlos López-Romero, Luis D'Marco, Ana Checa-Ros, María Peris-Fernández, Enrique Garrigós-Almerich, María Carmen Ramos-Tomás, Ana Peris-Domingo, Julio Hernández-Jaras

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; solid organ transplant; nephrology

Online: 27 February 2023 (04:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0207.v1

Mild Chronic Kidney Disease Associated with Low Bone Formation and Decrease in Phosphate Transporters and Signaling Pathways Gene Expression

Evdokia Bogdanova, Airat Sadykov, Galina Ivanova, Irina Zubina, Olga Beresneva, Natalia Semenova, Olga Galkina, Marina Parastaeva, Vladimir Sharoyko, Vladimir Dobronravov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic kidney disease; bone remodeling; static bone histomorphometry; inorganic phosphate transporters; intracellular signaling

Online: 13 February 2023 (08:46:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0408.v1

Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis

Diane D. Addie, Flora Bellini, Johanna Covell-Ritchie, Ben Crowe, Sheryl Curran, Mark Fosbery, Stuart Hills, Eric Johnson, Carrie Johnson, Steven Lloyd, Os Jarrett

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: feline coronavirus; feline infectious peritonitis; FIP prevention; GS-441524; chronic enteritis; inflammatory bowel disease; IBD; antiviral; diarrhea; itraconazole.

Online: 23 January 2023 (09:43:21 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202301.0379.v1

Combined Invasive Peripheral Nerve Stimulation in the Management of Chronic Post-Intracranial Disorder Headache. A Case Report.

Athanasia Alexoudi, Eustathios Vlahakis, Stamatios Banos, Konstantinos Oikonomou, Panayiotis Patrikelis, Anastasia Verentzioti, Maria Stefanatou, Stylianos Gatzonis, Stefanos Korfias, Damianos Sakas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Combined Peripheral Nerve Stimulation; occipital nerve stimulation; secondary headache disor-ders; chronic post-intracranial disorder headache and case report

Online: 23 January 2023 (00:57:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0293.v1

Sociobehavioral, Biological and Health Characteristics of Riverside People in the Xingu Region, Pará, Brazil

Dalberto Lucianelli-Junior, Adenilson Leão Pereira, Ozélia Sousa Santos, Maria do Carmo Faria Paes, Yuji Magalhães Ikuta, Rodrigo Silveira, Fernanda Nogueira Valentin

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: education level; eating behavior; healthy lifestyle habits; non-communicable chronic diseases; machine learning

Online: 17 January 2023 (01:52:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0245.v1

Leisure-time Physical Inactivity is Associated with Glycemic Alterations: COVID-Inconfidentes

Samara Silva de Moura, Luiz Antônio Alves de Menezes-Júnior, Ana Maria Sampaio Rocha, Aline Priscila Batista, Mariana Carvalho de Menezes, Julia Cristina Cardoso Carraro, George Luiz Lins Machado-Coelho, Adriana Lúcia Meireles

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; glycated hemoglobin; glycemic changes; physical inactivity; chronic diseases; public health

Online: 13 January 2023 (09:18:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0168.v1

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Connie Rojas, Zhandra Entrolezo, Jessica K. Jarett, Guillaume Jospin, Dawn Kingsbury, Alex Martin, Jonathan A. Eisen, Holly H Ganz

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: fecal microbiota transplant; domestic cat; chronic enteropathies

Online: 10 January 2023 (02:15:25 CET)

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

Preprint ARTICLE | doi:10.20944/preprints202301.0158.v1

Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet

Ryoya Togashi, Mutsuaki Edama, Mayuu Shagawa, Haruki Osanami, Hrotake Yokota, Ryo Hirabayashi, Chie Sekine, Tomonobu Ishigaki, Hiroshi Akuzawa, Yuki Yamada, Taku Toriumi, Ikuo Kageyama

Subject: Physical Sciences, Biophysics Keywords: subtalar joint instability; chronic ankle instability; footprint osteoarthritis

Online: 9 January 2023 (09:22:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0358.v1

Prevalence, Location, and Interference with Daily Life of Chronic Pain in Long-Term Survivors after Discharge from a Tertiary Emergency Center

Naoya Hashimoto, Takeshi Unoki, Nozomi Nagano, Ryota Funamizu, Keigo Sawamoto

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: chronic pain; intensive care units; critical care; critical illness; post-intensive care syndrome; emergency medicine

Online: 20 December 2022 (07:45:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0298.v1

Insights of Endocytosis Signaling in Health and Disease

Chandramani Pathak, Foram U. Vaidya, Bhargav N. Waghela, Pradeep Kumar Jaiswara, Vishal Kumar Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu Ranjan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endocytosis; Phagocytosis; Pinocytosis; Receptor endocytosis signaling; Chronic diseases

Online: 16 December 2022 (08:07:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0287.v1

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Luis L. Ayusso, Ana Paula Girol, Emmanuel A. Burdmann

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Online: 15 December 2022 (15:48:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0224.v1

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Varvara A Ryabkova, Natalia Y Gavrilova, Alina A Poletaeva, Aleksandr I Pukhalenko, Irina A Koshkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome; autoantibodies; autoimmunity

Online: 13 December 2022 (02:47:48 CET)

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(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.

Preprint ARTICLE | doi:10.20944/preprints202212.0211.v1

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Xinming Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: klotho; estrogen; hippocampus; chronic stress; sex difference; stress resilience

Online: 13 December 2022 (01:09:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0552.v1

Cryptic Oral Microbiota: What is its Role as OSA-related Periodontal Pathogens?

Mayra Alexandra Téllez Corral, Eddy Herrera Daza, Hayde Kamila Cuervo Jimenez, María del Mar Bravo Becerra, Jean Carlos Villamil, Patricia Hidalgo Martinez, Nelly S. Roa Molina, Liliana Otero, María E. Cortés, Claudia M. Parra Giraldo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: periodontitis; obstructive sleep apnea; oral microbiota; pathogenic microbiota; chronic diseases; MALDI-TOF

Online: 29 November 2022 (13:09:35 CET)

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Commonly the periodontitis has been linked to periodontopathogens categorized in Socransky's microbial complexes, however, there is a lack of knowledge regarding “other microorganisms” or "cryptic microorganisms", which are rarely thought of as significant oral pathogens and are neither previously categorized nor connected to illnesses in the oral cavity. This study hypothesized that these cryptic microorganisms could contribute to the modulation of oral microbiota present in health or disease (periodontitis and/or OSA patients). For this purpose, the presence and the correlation among these cultivable cryptic oral microorganisms were identified and their possible role in both conditions was determined. Data from oral samples of individuals with or without periodontitis and with or without OSA were obtained from a previous study. Demographic data, clinical oral characteristics, and genera and species of cultivable cryptic oral microorganisms identified by MALDI-TOF were recorded. The data of 75 participants were analyzed to determine the relative frequencies of cultivable cryptic microorganisms’ genus and species, microbial clusters and correlations tests were performed. According to periodontal condition, Gingivitis - dental biofilm-induced in reduced periodontium and stage III periodontitis were found to have the highest diversity of cryptic microorganism species. Based on the experimental condition these findings showed that there are genera related to disease conditions and others related to healthy conditions, with species that could be related to different chronic diseases being highlighted as comorbidities periodontitis and OSA. The cryptic microorganisms within the oral microbiota of patients with periodontitis and OSA are present as potential pathogens, promoting the development of dysbiotic microbiota, and the occurrence of chronic diseases, which have been previously proposed to be common risk factors for periodontitis and OSA. Understanding the function of possible pathogens in the oral microbiota will take more research.

Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0410.v1

Selenylated imidazo[1,2-a]pyridine induces cell senescence and oxidative stress in chronic myeloid leukemia cells

Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero1, Jamal Rafique, Eduardo Benedetti Parisotto

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Leukemia; imidazo[1,2-a]pyridines; selenide; oxidative stress; senescence; chronic myeloid leu-kemia.

Online: 22 November 2022 (07:49:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0236.v1

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.

Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Acute exacerbation chronic obstructive pulmonary disease (AECOPD); platelet-to-lymphocyte ratio (PLR); neutrophil-to-lymphocyte ratio (NLR); monocyte-to-lymphocyte ratio (MLR); baso-phil-to-lymphocyte ratio (BLR); eosinophil-to-lymphocyte ratio (ELR); in-hospital mortality; nom-ogram; decision curve analysis (DCA); clinical impact curve (CIC)

Online: 14 November 2022 (04:42:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0039.v1

Genomic Analysis of Adaptation of the MRSA ST239 Strains to the Development of Various Types of the Infectious Process

Olga Alexandrovna Dmitrenko, Andrey Viktorovich Chaplin, Anna Alexandrovna Balbutskaya, Tamara Yakovlevna Pkhakadze, Sergey Vladimirovich Alkhovsky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus, MRSA ST239, osteomyelitis, genome features, adaptation; chronic infection

Online: 2 November 2022 (03:34:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0142.v1

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Ana C. Gonçalves, Amícal Falcão, Gilberto Alves, João A. Lopes, Luís R. Silva

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: bioactive compounds; anthocyanins; drug delivery system; nanoparticles; chronic diseases; health benefits

Online: 11 October 2022 (05:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0100.v1

Electrocardiogram, Echocardiogram and NT-proBNP in Screening for Thromboembolism Pulmonary Hypertension in Patients after Pulmonary Embolism

Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Iwona Dudzik-Niewiadomska, Michał Machowski, Marek Roik, Małgorzata Wiśniewska, Jan Siwiec, Izabela Magdalena Staniszewska, Piotr Pruszczyk

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: screening after pulmonary embolism; chronic thromboembolic pulmonary disease; chronic thromboembolic pulmonary hypertension; diagnostic work-up of post-pulmonary syndrome

Online: 9 October 2022 (02:09:20 CEST)

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Background: The annual mortality of patients with untreated chronic thromboembolism pulmonary hypertension (CTEPH) is approximately 50% unless a timely diagnosis is followed by adequate treatment. In pulmonary embolism (PE) survivors with functional limitation the diagnostic work-up starts with echocardiography. It is followed by lung scintigraphy and right heart catheterization. However, noninvasive test providing diagnostic clues to CTEPH, or ascertain this diagnosis as very unlikely, would be extremely useful since the majority of post PE functional limitations is caused by deconditioning. Methods: Patients after acute PE underwent a structured clinical evaluation with electrocardiogram, routine laboratory tests including NT-proBNP and echocardiography. The aim of study was to verify whether the parameters from echocardiographic or perhaps electrocardiographic examination and NT-proBNP concentration best determine the risk of CTEPH. Results: A total (n = 261, male n = 123) patients after PE were included into the study, in group of 155 patients (59.4%) with reported functional impairment 13 patients (8.4%) had CTEPH and 7 PE survivors had chronic thromboembolic pulmonary disease (CTEPD) (4,5%). Echo parameters differed significantly between CTEPH/CTEPD cases and other symptomatic PE survivors. Patients with CTEPH/CTEPD had also higher level of NT-proBNP (p = 0.022) but concentration of NT-proBNP above 125 pg/ml did not differentiate patients with CTEPH/CTEPD (p>0.05). Additionally, proportion of patients with right bundle brunch block registered in ECG was higher in group with CTEPH/CTED (23.5% vs. 5.8%, p = 0.034) but there were no differences between other ECG characteristics of right ventricle overload. Conclusion: Screening for CTEPH/CTEPD should be performed in patients with reduced exercise tolerance compared to pre PE period, It is not effective in asymptomatic PE survivors. Patients with CTEPH/CTED had predominantly abnormalities indicatingchronic thromboembolism in the echocardiographic assessment. NT-proBNP and electrocardiographic characteristics of right ventricle overload proved to be insufficient in predicting CTEPH/CTEPD development.

Preprint ARTICLE | doi:10.20944/preprints202209.0289.v1

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?

Varvara A. Ryabkova, Natalia Y Gavrilova, Tamara V Fedotkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; post-COVID syndrome; postural orthostatic tachycardia; microcirculation; immune system

Online: 20 September 2022 (03:37:00 CEST)

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A Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology under growing interest now in view of the increasingly recognized post-COVID syndrome as a new entity with similar clinical presentation. We performed the first cross-sectional study of ME/CFS in community population in Russia and then described and compared some clinical and pathophysiological characteristics of ME/CFS and post-COVID syndrome as neuroimmune disorders. Of the cohort of 76 individuals who suggested themselves suffering from ME/CFS 56 subsequently were confirmed as having CFS/ME according to ≥1 of the 4 most commonly used case definition. Of the cohort of 14 individuals with post-COVID-19 syndrome 14 met diagnostic criteria for ME/CFS. The prevalence of clinically expressed and subclinical anxiety and depression in ME / CFS and post-COVID ME/CFS did not differ significantly from that in healthy individuals. Severity of anxiety / depressive symptoms did not correlate with the severity of fatigue neigther in ME / CFS nor in post-COVID ME/CFS, but the positive correlation was found between the severity of fatigue and 20 other symptoms of ME / CFS related to the domains of “post-exertional exhaustion”, “immune dysfunction”, “sleep disturbances”, "dysfunction of the autonomic nervous system", "neurological sensory / motor disorders" and "pain syndromes". Immunological abnormalities were identified in 12/12 patients with ME / CFS according to the results of laboratory testing. The prevalence of postural orthostatic tachycardia assessed by the active standing test was 37.5% in ME / CFS and 75.0% in post-COVID ME/CFS (the latter was higher than in healthy controls, p = 0.02) There was a more pronounced increase in heart rate starting from the 6th minute of the test in post-COVID ME/CFS compared with the control group. Assessment of the functional characteristics of microcirculation by laser doppler flowmetry revealed obvious and very similar changes in ME/CFS and post-COVID ME/CFS compared to the healthy controls. The identified pattern corresponded to the hyperemic form of microcirculation disorders, usually observed in acute inflammatory processes or in deficiency of systemic vasoconstriction influences.

Preprint ARTICLE | doi:10.20944/preprints202209.0178.v1

A Prospective Cohort Study: Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting

Marcin Wiech, Sławomir Żurek, Arkadiusz Kurowicki, Beata Horeczy, Mirosław Czczuwar, Paweł Piwowarczyk, Kazimierz Widenka, Michał Borys

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic postoperative pain; erector spinae plane block; coronary artery bypass grafting; Neuropathic Pain Symptom Inventory

Online: 13 September 2022 (11:24:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0137.v1

Machine Learning Classification of Specific Serologic Cytokines May Improve Detection of Recent, Fall Induced, Sub-Concussional Brain Changes in Geriatric Nondemented Subjects

Eduard Drima, Camelia Vrabie

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic geriatric inflammation; machine learning C4.5 classification; brain ventricular volumes; recent fall; subconcussive brain trauma

Online: 9 September 2022 (13:05:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0123.v1

Falls Incidence and Associated Risk Factors among People with Chronic Obstructive Pulmonary Disease (COPD)

Mehrdad Davoudi, Seyyed Mohammadreza Shokouhyan, Mohsen Abedi, Mehdi Rezaei, Mohamad Parnianpour, Kinda Khalaf, Masood Mazaheri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic obstructive pulmonary disease; COPD; fall risk factor; gait; balance; cognition; daily activity; muscle dysfunction

Online: 8 September 2022 (10:35:01 CEST)

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Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a systemic disease rather than a mere disorder of the lungs. Central (respiratory) and peripheral (limb) muscle weakness are among the main pronounced systemic effects of COPD. While the disease primarily affects the lower limb muscles and contributes to gait impairment, COPD is also associated with an increasing risk of falls in patients (COPDp). Previous studies have reported higher rates of falls among COPDp (1.17 to 1.20 falls/person-year), amounting to four times higher than an age-matched healthy group. Potential fall risk factors include muscle weakness, impaired daily activities, cognitive dysfunction, and gait and balance impairment. Although COPDp often manifest many of these risk factors, there remains a gap in literature regarding falls during walking in this population. This study aimed to 1. analyze the literature to identify the risk factors of falling in COPDp, and 2. investigate the underlying mechanisms by which these risk factors can lead to increased prevalence of falling. The results suggest that in addition to the known risk factors of falling, low back pain and mental fatigue should also be considered as relevant risk factors in the treatment process of these patients. Moreover, respiratory problems, which are common in this population, have demonstrated pronounced effects on energy expenditure, gait, and other types of activities of daily living (ADLs), leading to reduced intensity, disrupted coordination of the trunk-pelvic structure with the lower limbs during gait, and altered motor control performance due to activation of muscles in an inefficient synergic manner. These problems potentially lead to the increased vulnerability of these patients to external disturbances and higher incidence risk of falls and injuries. Cognitive problems, which are typically due to reduced oxygen received by the brain, as well as general inflammation caused by COPD, also play a significant role in gait disruption and balance. Future research is warranted to determine the prevalence of falls in COPDp by examining the response of these patients to Medio-Lateral (ML) and Anterior-Posterior (AP) disturbances during gait in association with traditional and recommended fall risk factors.

Preprint CASE REPORT | doi:10.20944/preprints202209.0035.v2

Application of Amniotic Membrane Allografts in Advanced Venous Leg Ulcer: A Case Study and Literature Review

Naomi Lambert, Eric Vinke, Tyler Barrett, Matthew Regulski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic Venous Insufficiency; Venous Leg Ulcer; Dehydrated Amniotic Membrane Allograft

Online: 5 September 2022 (10:57:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0495.v1

Deep Learning Approaches to Automatic Chronic Venous Disease Classification

Marina Barulina, Aschat Sanbaev, Sergey Okunkov, Ivan Ulitin, Ivan Okoneshnikov

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: chronic venous disease; deep leaning; data mining; Resnet50; DeiT; automatic classification; automatic CEAP classification

Online: 29 August 2022 (12:46:56 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202208.0398.v1

Use of Rotavirus Vaccine as a Containment Measure for SARS-CoV-2 Coronavirus (COVID-19): A Study of Possible Cross and Trained Immunity

Nuria Lorite - Ayan

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: rotavirus; coronavirus; vaccine; SARS-CoV-2; COVID-19; cross immunity; trained immunity; vaccinated breakthrough infections; COVID variants; long-Covid; post-viral syndrome; chronic fatigue; booster

Online: 23 August 2022 (10:50:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0292.v1

Study the Correlation between the Mother-To-Child Transmission Risk Factors in Chronic Hepatitis B Virus Infection Pregnant Women in Vietnam by HCA Method

Tram Thi Ngoc Hoang, Thi Thu Huong Bui, Thi Thuy Pham, Thi Lan Anh Luong, Thi Kim Phuong Doan, Thu Lan Hoang, Cam Tu Ho, Nina Koerber, Khanh Lam Ho, Duc Hinh Nguyen, Tanja Bauer, Ulrike Protzer, Tien Dung Nguyen

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Chronic Hepatitis B Virus Infection; Liver; Pregnant Women; Cord blood; PBMCs (Peripheral Blood Mononuclear Cells); subclinical index

Online: 16 August 2022 (14:17:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0361.v1

Combining Awake Anesthesia with Minimal Invasive Surgery Optimizes Intraoperative Surgical Spinal Cord Stimulation Lead Placement

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Chantal Wood, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Emmanuel Cuny, Jimmy Voirin, Denys Fontaine, Sylvie Raoul, Patrick Mertens, Philippe Peruzzi, François Caire, Nadia Buisset, Romain David, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: PSPS; FBSS; SCS; surgical lead; SCS implantation; MAST (for Minimal Access Spine Technologies); TCIVA (for Target Controlled Intra-Veinous Anesthesia); composite score; pain mapping; neuropathic pain; chronic pain; quality of life; anesthesia; hypnosis

Online: 25 July 2022 (08:34:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0171.v1

The Effects of Chronic Stress on Neuroanatomy and Cognitive Function

Niki Viradia, Jesica Godinez Paredes, Syed Hassan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s; aging; amygdala; brain plasticity; CA1; CA3; chronic stress; cognition; GABA; HIF-1; hippocampus; hypoxia; neurogenesis; Parkinson’s; prefrontal cortex; PSA-NCAM; ROS; spatial learning

Online: 12 July 2022 (04:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0036.v1

Discordance in Addressing Opioid Crisis in Rural Communities: Patient and Provider Perspectives

Bonyan A. Qudah, Martha A. Maurer, David A. Mott, Michelle A. Chui

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: opioid use disorder; chronic pain; medications for opioid use disorder; stigma; rural health

Online: 4 July 2022 (07:54:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0168.v1

The Impact of Spiritual-Based Care Interventions on the Quality of Life of Children with Chronic Diseases: a Philosophical Perspective

Idyatul Hasanah, Moses Glorino Rumambo Pandin, Tita Rohita

Subject: Public Health And Healthcare, Nursing Keywords: Nursing; Spiritual care; Quality of life; Chronic disease; Children

Online: 13 June 2022 (05:17:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0249.v1

Adult Presentation of X-Linked Hypophosphatemia

Nobuaki Ito

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: X-linked hypophosphatemia; fibroblast growth factor 23; osteomalacia; enthesopathy; secondary hyperparathyroidism; tertiary hyperparathyroidism; chronic kidney disease; oral disease; quality of life; burosumab

Online: 19 May 2022 (04:03:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0008.v1

CRISPR/Cas9-directed Gene Trap Constitutes a Selection System for Corrected BCR/ABL Leukemic Cells in CML

Elena Vuelta, José Luis Ordoñez, David José Sanz, Sandra Ballesteros, Jesús María Hernández-Rivas, Lucía Méndez-Sánchez, Manuel Sánchez-Martín, Ignacio García-Tuñón

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Chronic Myeloid Leukaemia; BCR/ABL; CRISPR; Gene therapy; CRISPR-Trap.

Online: 4 May 2022 (12:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0296.v1

Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Literature Review

Richard I. Horowitz, Phyllis R. Freeman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dapsone; disulfiram; chronic Lyme disease; Post-Treatment Lyme Disease Syndrome; babesia; bartonella; persisters; biofilms.

Online: 29 April 2022 (10:12:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0233.v1

Relationship Between ACE I/D Polymorphism and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease

Hendri Susilo, Budi Susetyo Pikir, Mochammad Thaha, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Ifan Ali Wafa, Cennikon Pakpahan, Delvac Oceandy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic kidney disease; gene polymorphism; angiotensin-converting enzyme; cardiovascular disease; cardiovascular mortality risk; genotype

Online: 26 April 2022 (10:05:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0217.v1

Factors Associated with the Prevalence of Malnutrition among Adult Haemodialytic Patients: A Two-Centre Study in Jeddah Region, Saudi Arabia

Firas S. Azzeh, Waad M. Turkistani, Mazen M. Ghaith, Lujain A. Bahubaish, Osama A. Kensara, Hussain A. Almasmoum, Abdullah F. Aldairi, Anmar A. Khan, Ahmad A. Alghamdi, Ghalia Shamlan, Maha H. Alhussain, Reham M. Algheshairy, Abdullah M. AlShahrani, Maysoun S. Qutob, Awfa Y. Alazzeh, Haitham M. Qutob

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chronic Kidney Disease; Protein-Energy Wasting; Modified-Subjective Global Assessment

Online: 25 April 2022 (04:53:13 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202201.0418.v2

Unnatural Cycles: Anthropogenic Disruption To Health And Planetary Functions

Gillian Gibson, Alex G. Stewart

Subject: Environmental And Earth Sciences, Environmental Science Keywords: natural cycles; air pollution; asthma; chronic obstructive airways disease; mining; sustainability; circular economy

Online: 4 March 2022 (12:58:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0353.v1

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

Fatkhu Rahman, Syahrul Tuba

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetic; Chronic Kidney Disease; Metformin; Acidosis Lactate

Online: 28 February 2022 (09:28:33 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202202.0288.v1

A Case of Focal Segmental Glomerulosclerosis in a Young Girl with a Very Low Birth Weight

Yasuyo Kashiwagi, Kazushi Agata, Gaku Yamanaka, Hisashi Kawashima

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chronic kidney disease; low birth weight; focal segmental glomerulosclerosis; two-hit theory

Online: 23 February 2022 (08:26:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0237.v1

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

Sadiq Maifata, Fauzah Abd Ghani, Rafidah Hod, Nor Fadhlina Zakaria

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Membranous glomerulonephritis; remission; nephrotic syndrome; chronic kidney disease; end-stage kidney diseases

Online: 18 February 2022 (14:49:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0290.v3

Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis

Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos López-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: crescentic glomerulonephritis; BET proteins; NOTCH; GREMLIN; Chronic kidney disease; Bromodomain

Online: 23 December 2021 (14:40:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0103.v1

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

Rodney R. Dietert, Janice M. Dietert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: microbiome; adverse childhood experiences (ACEs); gerobiotics, microimmunosome; healthspan; circadian rhythms; sleep disorders; noncommunicable diseases and conditions (NCDs); chronic disorders; early life programming

Online: 7 December 2021 (12:48:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0041.v1

Genetics of Vascular Inflammation in Lower Limb Ischemia: The TNF-α Hypothesis in Peripheral Arterial Disease

Diego Caicedo, Clara V. Álvarez, Sihara Pérez, Jesús Devesa

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Vascular inflammation; Peripheral arterial disease (PAD); Chronic limb-threatening ischemia (CLTI); GHAS trial; TNF-α; hs-CRP; Neutrophil-to-lymphocyte ratio (NLR); NOX4; eNOS; VEGF-A.

Online: 3 December 2021 (09:44:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0552.v1

Intra Articular Ozone Modulates Inflammation and Has Anabolic Effect on Knee Osteoarthritis: IL-6 and IGF-1 as Pro-Inflammatory and Anabolic Biomarkers

Marcos E. Fernández-Cuadros, Olga S. Pérez-Moro, María J Albaladejo-Florín, Rubén Algarra-López, María M. Tobar-Izquierdo, Amelia Magaña-Sánchez, Patricia Jiménez-Cuevas, Javier Rodríguez-de-Cía

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: ozone; ozone therapy; cytokines; biomarkers; IL-6; inflammation; chronic inflammation; IGF-1; anabolism; knee osteoarthritis; pain; function; c-reactive protein; uric acid

Online: 29 November 2021 (19:08:10 CET)

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Objectives: 1) to demonstrate the anti-inflammatory and anabolic effect of Ozone by determining in serum samples the biochemical levels of IL-6 and IGF-1 in knee osteoarthritis (OA) patients in a real world in Rehabilitation Setting; 2) to evaluate clinical effectiveness by Visual Analog Scale (VAS) and WOMAC scale, and biochemical effect by C-reactive protein (CRP), uric acid and erythrocyte sedimentation rate (ESR). Material and methods: 65 patients with knee OA Kellgren Lawrence (KL) grade 2 or more were analyzed in a retrospective observational study. The study run from January 2018 to September 2021. Inclusion criteria: a) patients 18 years or older; b) with knee OA KL 2º or more; c) biochemical analysis before-and-after treatment; d) pain more than 3 on VAS. Exclusion Criteria: a) previous knee surgery; b) favism; c) pregnancy; d) any other disease that originates lack of collaboration for infiltration. Primary Outcome variables: a) IL-6; b) IGF-1 in diabetes mellitus (DM)/obese and non-DM/non-obese patients; both before-and-after Ozone treatment. Secondary Outcome variables: a) CRP, b) ESR, c) uric acid, d) VAS pain, e) WOMAC pain, function and stiffness. Ozone protocol consisted of 4 sessions (once a week) of an intra-articular infiltration of 20 mL (20µg/mL concentration) of a gas mixture of Oxygen-Ozone 95-5% (produced by Ozone generator Ozonosan-α Plus ®). For biochemical evaluation, SNIBE MAGLUMI ™ IL-6 (CLIA) and SNIBE MAGLUMI ™ IGF-1 (CLIA) kits were used. CRP and uric acid were analyzed by Abbott Alinity c kit; and ESR was evaluated by DIESSE VES MATIC CUBE 30. Results: There is a linear correlation between age and OA severity. IL-6 decreased both in DM and non-DM patients and in all OA KL grades (from 2.7 to 1.59 pg/mL). IGF-1 decreased in total group (OA + DM + obesity) from 112.09 to 107.19 ng/mL. When only knee OA patients were analyzed, Ozone improved IGF-1 levels (from 100.17 to 102.03 ng/mL). Ozone decreased CRP, ESR, uric acid, and improved VAS pain, WOMAC pain, function and stiffness (p<0.05). Conclusions: Ozone is a valid option for the management of knee osteoarthritis in real world Rehabilitation Setting, because of its anti-inflammatory, metabolic and anabolic properties. Ozone downregulates pro-inflammatory IL-6 cytokine. Ozone has a metabolic/hypoglycemic effect on obese/diabetic knee osteoarthritis patients by reducing IGF-1. Ozone has an anabolic effect on non-diabetic/non-obese patients by improving IGF-1. Ozone reduces other biomarkers of inflammation (CRP, ESR and uric acid) and improves, pain, function and quality of life.

Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0484.v1

Disinhibited-Like Behavior Correlates With Frontal Cortex Damage in Alcohol-Induced Wernicke-Korsakoff Syndrome

Marta Moya, Leticia López-Valencia, Borja García-Bueno, Laura Orio

Subject: Social Sciences, Behavior Sciences Keywords: Chronic alcohol; Thiamine Deficiency; Disinhibition; Wernicke´s Encephalopathy; Recognition memory; Nitrosative stress; Lipid peroxidation; Apoptosis; Cell damage; Nutritional deficit

Online: 25 November 2021 (16:03:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0478.v1

You + ME Registry: A Research Platform to Facilitate Clinical and Therapeutic Discoveries in ME/CFS and Related Diseases

Allison Ramiller, Kathleen Mudie, Elle Seibert, Sadie Whittaker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Long COVID; data acquisition source; post-infectious; longitudinal cohort study; patient-powered

Online: 25 November 2021 (13:51:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0460.v1

Low-Phosphate Meals Accompanied by a Minimum Dose of CaCO₃ Downregulates Pro-inflammation by Reducing CKD-MBD Indicators and Triggers by Decreasing Dietary Phosphate Intake

Barbara Ying-Jung Chen, Mei-Yi Wu, Mei-Yun Chin, Mai-Szu Wu, Jiun-Rong Chen

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Maintenance hemodialysis (MHD) patient; Low-phosphate meal; CKD-MBD (chronic kidney disease-related mineral and bone disorder); Proinflammatory cytokine; TNF-α (tumor necrosis factor-alpha)

Online: 24 November 2021 (15:27:03 CET)

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High dietary phosphate intake and poor adherence to phosphate-binding-therapy elevate the risk of hyperphosphatemia in maintenance hemodialysis (HD; MHD) patients. Therefore, chronic kidney disease-related mineral and bone disorder (CKD-MBD) indicators increase; consequently, risks of CKD-MBDs and inflammation are elevated. This double-blind, randomized control trial intervention study was designed to investigate the possibility of reducing blood CKD-MBD indicators and modulating inflammatory indicators by consuming low-phosphate (LP) meals accompanied by a minimum dose of a calcium-based phosphate binder (CaCO3). MHD patients were recruited and randomly assigned to an LP meal group (LP group) or a control group. After initial data collection, blood collection, and dietary counseling, subjects were asked to consume a washout diet for 1 week. During the washout diet period, subjects consumed their usual diet but took 1 tablet of calcium carbonate (1CaCO3) as a phosphate binder with each meal. After the washout diet period, subjects in the LP group and control group respectively consumed LP meals and regular meals twice a day for 1 week. Meat in the LP meals was boiled before the regular cooking process, but meat in control meals was not. All meals were supplied by a central kitchen so that the contents of phosphate and other nutrients could be identified. In total, 40 MHD patients completed the study program. After 1 week of the dietary intervention, the blood Ca x P product and dietary phosphate had significantly decreased in the LP group compared to the control group (p<0.05). The LP group had significantly lower variations in dietary phosphate intake, blood calcium, Ca x P product, and tumor necrosis factor (TNF)-α than the control group by comparing differences between after the dietary intervention and the baseline (△after intervention - baseline, p<0.05). The increase in dietary phosphate intake (△3rd - 2nd dietary phosphate intake) augmented the increase in the TNF-α level by 6.24-fold (odds ratio [95% confidence interval]: 6.24 [1.12~34.92], p<0.05). These results highlighted the conclusion that LP meals accompanied by a minimum dose of CaCO3 downregulated pro-inflammation by reducing CKD-MBD indicators which was triggered by decreasing dietary phosphate intake.

Preprint ARTICLE | doi:10.20944/preprints202111.0420.v1

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM)

James N Baraniuk, Alison Amar, Haris Pepermintwala, Stuart D Washington

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Midbrain; postexertional malaise; PEM, arousal; exercise; fMRI; autonomic; postural tachycardia; Myalgic Encephalomyelitis / Chronic Fatigue Syndrome; ME/CFS; Gulf War Illness; GWI

Online: 23 November 2021 (10:53:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0342.v1

Factors Associated With Chronic Kidney Disease in Patients With Type 2 Diabetes in Bangladesh

Sheikh Mohammed Shariful Islam, Masudus Salehin, Sojib Bin Zaman, Tania Tansi, Rajat Das Gupta, Lingkan Barua, Palash C Banik, Riaz Uddin

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 Diabetes Mellitus; Chronic Kidney Diseases; Hypertension; Risk Factors; Bangladesh

Online: 19 November 2021 (09:26:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0253.v1

Personalized Cell Therapy for Patients With Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-based Responder and Non-responder Prediction

Amankeldi Salybekov, Markus Wolfien, Shuzo Kobayashi, Takayuki Asahara

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cell therapy; chronic limb-threating ischemia; peripheral artery disease; diabetes; atherosclerosis obliterans; thromboangiitis obliterans; personalized medicine; artificial intelligence; machine learning; genome-wide association studies; transcriptome-wide association studies; clonal hematopoiesis of indeterminate potential.

Online: 15 November 2021 (11:18:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0318.v1

Probiotics Role in Chronic Rhinosinusitis Treatment: an Update of the Current Literature

Maria Rita Bianco, Massimo Ralli, Domenico Michele Modica, Marta Amata, Salvatore Poma, Gianfranco Mattina, Eugenia Allegra

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic rhinosinusitis; probiotics; microbiome; nasal microbiota; microbiome therapy

Online: 21 October 2021 (23:00:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0233.v1

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Rodney R. Dietert

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: microbiome; public health; chronic diseases; microimmunosome; eating disorders; subtance use disorder; commensals; pathobionts; sensory receptors; developmental programming

Online: 15 October 2021 (16:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0511.v1

Oxygen, pH, Lactate, and Metabolism- How Old Knowledge and New Insights Might be Combined for New Wound Treatment

Herbert Leopold Haller, Frank Sander, Sebastian Philipp Nischwitz, Daniel Popp, Matthias Rapp, Bernd Hartmann, Mehmet Demircan, Lars Peter Kamolz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Wound; chronic wound; hypoxia; Lactate; Acidosis; Alkalosis; neoangiogenesis; ECM; Polylactide; polylactide membranes

Online: 30 September 2021 (12:18:52 CEST)

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: Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metallopro-teinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized "biorector," disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and pro-liferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound's pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wound. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0416.v1

Chronic Diseases Associated with Malassezia Yeast

Abdourahim Abdillah, Stéphane Ranque

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Malassezia; Chronic diseases; psoriasis; atopic dermatitis; chronic rhinosinusitis; asthma; cystic fibrosis; HIV infection; inflammatory bowel disease; colorectal cancer; neurodegenerative diseases

Online: 24 September 2021 (08:13:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0201.v1

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB and Wnt/Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis andChronic Fatigue Syndrome: A Review and New Hypothesis Based on Results of Network, Enrichment and Annotation Analyses

Michael Maes, Marta Kubera, Magdalena Kotańska

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; Myalgic Encephalomyelitis; inflammation; neuro-immune; oxidative and nitrosative stress; antioxidants

Online: 13 September 2021 (10:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0071.v1

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

Thomas Duflot, Ly Tu, Matthieu Leuillier, Hind Messaoudi, Déborah Groussard, Saïda Azhar, Raphaël Thuillet, Marc Humbert, Vincent Richard, Christophe Guignabert, Jérémy Bellien

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: lysophospholipids; lysophosphatidic acids; cardiovascular diseases; HPLC-MS/MS; rodent models; pulmonary hypertension; chronic heart failure; hypertension

Online: 3 September 2021 (15:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0545.v1

A Novel Multi-dimensional Clinical Response Index Dedicated to Improving Global Assessment of Pain in Patients with Persistent Spinal Pain Syndrome After Spinal Surgery, Based on a Real-life Prospective Multicentric Study (PREDIBACK) and Machine Learning

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Nicolas Naiditch, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Nelly Grimaud, Nihel Adjali, Kevin Nivole, Mathilde Many, Romain David, Chantal H. Wood, Raphael Rigoard, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Composite score; Machine learning; PSPS; Failed Back Surgery Syndrome (FBSS); Chronic pain; Pain Intensity; Quality of Life; Pain Mapping; Pain Surface; Functional Capacity; Psychological Distress; Anxiety and Depression

Online: 30 August 2021 (13:04:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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