Article
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Beraprost and Overall Survival in Cats With Chronic Kidney Disease
Version 1
: Received: 31 March 2023 / Approved: 31 March 2023 / Online: 31 March 2023 (11:17:14 CEST)
A peer-reviewed article of this Preprint also exists.
Ito, H.; Matsuura, T.; Sano, T. Beraprost and Overall Survival in Cats with Chronic Kidney Disease. Vet. Sci. 2023, 10, 459. Ito, H.; Matsuura, T.; Sano, T. Beraprost and Overall Survival in Cats with Chronic Kidney Disease. Vet. Sci. 2023, 10, 459.
Abstract
Background: Overall survival is the most important outcome for treatment response in feline chronic kidney disease (CKD). Beraprost has been shown to reduce the kidney function decline in cats with International Renal Interest Society (IRIS) stage 2 and 3 CKD. However, association with prolonged survival has not yet been examined. Objective: To assess the relationship between beraprost and overall survival in cats with CKD in real clinical practice. Animals: Client-owned cats with IRIS stage 3 CKD (n = 134), evaluated between 2017 and 2020. Methods: Retrospective cohort study based on data from electronic medical records of one hospital. Results: Multivariable Cox regression models on all treatment effects showed that beraprost only was related to better survival (P = 0.028). The cohort was divided into “beraprost therapy” and “no beraprost therapy” groups, and survival analyses revealed that overall survival was significantly longer in the beraprost therapy group, using Kaplan-Meier curves (P = 0.004). However, baseline phosphate is known to be an important prognostic indicator and was not well balanced between the two groups. Therefore, a subcohort of 97 cats was selected (those having baseline phosphate < 6.0 mg/dL) that allowed for this parameter to be balanced between groups. The survival data in this subcohort was consistent with that of the overall study cohort. Conclusions: In feline patients with CKD, beraprost therapy was associated with better overall survival.
Keywords
beraprost; feline; chronic kidney disease; progression-free survival; overall survival
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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