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Preprint ARTICLE | doi:10.20944/preprints201907.0033.v1

Plasma Spectroscopy of Various Types of Gypsum: An ideal Terrestrial Analogue

Abhishek K. Rai, Jayanta K. Pati, Christian G. Parigger, Awadhesh K. Rai

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: laser-induced plasma; atomic spectroscopy; laser-induced breakdown spectroscopy; 29 atomic spectroscopy; principal component analysis; partial least-square regression; gypsum; Mars

Online: 2 July 2019 (08:03:52 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1785.v1

Takotsubo Cardiomyopathy during Armed Conflict: A Case Series

Sharon Bruoha, Artyom Star, Gili Givaty, Michael Shilo, Michael Friger, Vladimir Chitoroga, Hezzy Shmueli, Yigal Abramowitz, Elad Asher, Jamal Jafari, Vladimir Shlyakhover, Doron Zahger, Moti Haim, Chaim Yosefy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Takotsubo cardiomyopathy; left ventricular dysfunction; stress-induced cardiomyopathy; war

Online: 28 March 2024 (14:53:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1721.v1

Familial Alzheimer’s Disease Neurons Bearing Mutations in PSEN1 Display Increased Calcium Responses to AMPA as an Early Calcium Dysregulation Phenotype

Helena Targa Dias Anastacio, Natalie Matosin, Lezanne Ooi

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; induced pluripotent stem cells; neurodegeneration; AMPA; glutamate

Online: 29 February 2024 (12:58:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1326.v1

Design and Implementation of a MIMO Integral Resonant Control for Active Vibration Control of Pedestrian Structures

Emiliano Pereira, Xidong Wang, Iván M. Díaz, Sumeet S. Aphale

Subject: Engineering, Control And Systems Engineering Keywords: Active Vibration Control; Human-Induced Vibrations; Integral Resonant Control

Online: 22 February 2024 (16:17:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0808.v1

Association between Molecular Initiating Events (MIEs) in Drug-Induced Hiccups

Ryuichiro Hosoya, Reiko Ishii-Nozawa, Tomoko Terajima, Hajime Kagaya, Yoshihiro Uesawa

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: drug-induced hiccups; FAERS; nuclear receptor; stress response pathways

Online: 15 February 2024 (01:25:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0764.v1

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards a new perspective.

María Ángeles González-Nicolás, Cristian González-Guerrero, Marian Goicoechea, Lisardo Boscá, Lara Valiño-Rivas, Alberto Lázaro

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Contrast-Induced Acute Kidney Injury; Biomarkers; Contrast Media; Nephrotoxicity

Online: 14 February 2024 (09:32:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1587.v1

Topography of UV-melanized Thalli of Lobaria pulmonaria (L.) Hoffm.

Amina G. Daminova, Anna E. Rassabina, Venera R. Khabibrakhmanova, Richard P. Beckett, Farida V. Minibayeva

Subject: Biology And Life Sciences, Plant Sciences Keywords: lichen; UV-induced melanization; melanin; topography; hydrolytic enzymes; microscopy

Online: 22 June 2023 (10:14:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0392.v1

Micro-Particles of High Entropy Alloys Made by Laser Induced Forward Transfer

Molong Han, Ashok Meghwal, Soon Hock Ng, Daniel Smith, Haoran Mu, Tomas Katkus, De Ming Zhu, Reiza Mukhlis, Jitraporn Vongsvivut, Christopher C Berndt, Andrew S. M. Ang, Saulius Juodkazis

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Laser induced forward transfer; high entropy alloys; micro-particles

Online: 26 September 2022 (10:32:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0209.v1

On the Localization of Persistent Currents due to Trapped Magnetic Flux at the Stacking Faults of Graphite at Room Temperature

Regina Ariskina, Markus Stiller, Christian Precker, Winfried Böhlmann, Pablo D. Esquinazi

Subject: Physical Sciences, Condensed Matter Physics Keywords: defect-induced superconductivity; graphite; stacking faults; magnetic force microscopy

Online: 22 April 2022 (03:43:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0357.v1

The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia

Maciej Socha, Bartosz Malinowski, Oskar Puk, Mariusz Dubiel, Michał Wiciński

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: NLRP3; inflammation; preeclampsia; pregnancy induced hypertension; HELLP syndrome; immunothrombosis

Online: 23 May 2020 (05:15:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0754.v1

The Spatially Differentiated Trends Between Forest Pest Control Efficiency and Pest-induded Losses in China

Qi Cai, Yushi Cai, Yali Wen

Subject: Business, Economics And Management, Economics Keywords: forest pest; control effeciency; pest-induced losses; spatially differentiated

Online: 2 November 2018 (09:32:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0426.v1

A Comparison of Empirical Procedures for Fatigue Damage Prediction in Instrumented Risers undergoing Vortex-Induced Vibration

Chen Shi, Lance Manuel, Michael Tognarelli

Subject: Engineering, Marine Engineering Keywords: riser; vortex-induced vibration; fatigue damage prediction; empirical method

Online: 21 September 2018 (04:04:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0041.v1

Integrative Bioinformatic Analysis of Transcriptomic Data Identifies Conserved Molecular Pathways Underlying Ionizing Radiation-Induced Bystander Effects (RIBE)

Constantinos Yeles, Efstathios-Iason Vlachavas, Olga Papadodima, Eleftherios Pilalis, Constantinos E. Vorgias, Alexandros G. Georgakilas, Aristotelis Chatziioannou

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Bioinformatics; Ionizing radiation; Microarrays; Radiation-induced bystander effects; Transcriptomics

Online: 6 November 2017 (15:02:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0553.v1

Accelerated gradient-based algorithm combined with progressive Big-Bang to optimize the layout in offshore wind farms

Angel Gaspar Gonzalez-Rodriguez, Juan Manuel Roldan-Fernandez, José Vicente Muñoz Díez

Subject: Engineering, Electrical And Electronic Engineering Keywords: Gradient descent algorithm; offshore wind farms; layout positioning; deficit aggregation; greedy repositioning; computation time

Online: 8 September 2023 (04:17:05 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202304.0829.v2

The Influence of Glycerol Flow through a Shielded Coil on an Enzyme Placed Near Its Side

Yuri D. Ivanov, Ivan D. Shumov, Andrey F. Kozlov, Maria O. Ershova, Anastasia A. Valueva, Irina A. Ivanova, Vadim Y. Tatur, Andrei A. Lukyanitsa, Nina D. Ivanova, Vadim S. Ziborov

Subject: Biology And Life Sciences, Biophysics Keywords: atomic force microscopy; horseradish peroxidase; enzyme aggregation; enzymatic activity; tribo-electric effect; fluid flow

Online: 12 June 2023 (04:15:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0743.v1

Identification and Classification of Causes and Risk Factors of Osteoporosis Based on Complex Intuitionistic Fuzzy Frank Aggregation Operators

Xiao-Peng Yang, Tahir Mahmood, Zeeshan Ali, Khizar Hayat

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: complex intuitionistic fuzzy sets; osteoporosis diseases; frank averaging/geometric aggregation operators; decision-making evaluations

Online: 10 May 2023 (10:52:02 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0163.v1

SSRIs as Risk Reduction for Cardiovascular Disease in Patients with Schizophrenia

Alfredo Bellon, Kieuhanh Nguyen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: cholesterol; BMI; blood sugar; psychosis; LDL; HDL; antidepressants; antipsychotics; metabolism; metabolic abnormalities, platelet aggregation

Online: 8 October 2020 (09:03:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0400.v1

p62, the Receptor for Selective Autophagy, Contributes in ATXN3 Aggregate Formation in Spinocerebellar Ataxia Type 3

Anna J. Zimmer, Carola Bahl, Jule M Schäfer, Jonasz Jeremiasz Weber, Olaf Riess, Jeannette Hübener-Schmid

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Spinocerebellar ataxia type 3; ataxin-3; p62/sequestosome-1; autophagy; autophagy impairment; co-localized aggregation

Online: 7 March 2024 (08:06:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1207.v1

How the Choice of the Starting Time of the Observation Day May Affect Daily Precipitation Amounts and Extremes: Problem Analysis and Adjustment Methods

Francesca Becherini, Claudio Stefanini, Antonio Della Valle, Francesco Rech, Fabio Zecchini, Dario Camuffo

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: daily precipitation; time of observation; time series; aggregation method; adjustment method; hourly dataset; daily extremes

Online: 22 February 2024 (01:19:32 CET)

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The study of precipitation amount at different time scales constitutes an important issue in climate research and risk assessment. When dealing with daily totals, a frequent but sometimes underestimated problem is at what time the observation day begins. The choice of different starting times may lead to incompatibility between stations and incorrect identification of extreme events. In this work, the problem of temporal misalignment between precipitation datasets characterized by different starting time of the observation day is analyzed. The most widely used adjustment methods (1day and uniform shift) and two methods based on reanalysis (NOAA and ERA5) are evaluated in terms of temporal alignment, precipitation statistics and percentile distributions. As test series, the precipitation amount collected from 9 a.m. local time (09 LT) on the previous day to 09 LT on the target day (9-9 datasets) of the Padua and nearby stations in the period 1993-2022 have been selected. Results show that the reanalysis-based methods, in particular ERA5, outperform the others in temporal alignment, regardless the station. But, for the periods in which reanalysis data are not available, “1day” method, which shifts the daily amount back one calendar day, and “unif” method, which distributes uniformly the daily total from a 2-day moving window surrounding the target date, can be considered valid alternatives. On the other side, concerning the precipitation statistics, the reanalysis-based methods are not the best option, as they increase the precipitation frequency and reduce the mean value over wet days, NOAA much more than ERA5. Nevertheless, the uniform method provides a larger deviation from the original daily series. The use of the series of a station nearby the target one, which is mandatory in case of missing data, gives similar or better results than applying any adjustment method to the 9-9 series. General conclusions can hardly be drawn as they depend on the method and station. For the Padua dataset, the analysis was repeated at monthly and seasonal resolution. In general, the adjustment series show the most relevant changes in the precipitation statistics in summer and less temporal alignment with the original series in summer and autumn, the two seasons mainly affected by heavy rains in Padua. Finally, the percentiles distribution, analyzed for all the methods and stations, indicates that any adjustment method underestimates the percentile values, except ERA5. Only Legnaro, the station most correlated with Padua, gives results like ERA5.

Preprint ARTICLE | doi:10.20944/preprints202310.0329.v1

Marine Cultural Target Detection for Underwater Robotics Based on Deep Aggregation Network with Deformation Convolution

Yutuo Yang, Wei Liang, Daoxian Zhou, Yinlong Zhang, Gaofei Xu

Subject: Computer Science And Mathematics, Robotics Keywords: autonomous underwater vehicle (AUV); underwater target detection; deformable convolution; multi-scale deep aggregation; attention mechanism

Online: 6 October 2023 (11:51:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1349.v1

A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected Mice

Kwadwo Ofori, Anurupa Ghosh, Dinesh Kumar Verma, Darice Wheeler, Gabriela N Cabrera, Jong-Bok Seo, Yong-Hwan Kim

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: α-Synuclein preformed fibrils (PFF); cytotoxicity; Reactive Oxygen Species (ROS); oxidative stress; and protein aggregation

Online: 18 August 2023 (10:55:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1531.v1

N-acetylcysteine Amide AD4 and Thioredoxin Mimetic Peptides Inhibit Platelet Aggregation and Protect from Oxidative Stress

Sonia Eligini, Marco Munno, Daphne Atlas, Cristina Banfi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: platelet; aggregation; N-acetylcysteine; N-acetylcysteine amide; thioredoxin mimetic peptides; clotting time; TxB2; 12-HETE

Online: 21 June 2023 (10:56:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0003.v1

Examination of Lower Limb Microcirculation in Diabetic Patients With and Without Intermittent Claudication

Katalin Biró, Barbara Sándor, Kinga Tótsimon, Katalin Koltai, Krisztina Fendrik, Dóra Endrei, Judit Vekasi, Kalman Toth, Gábor Késmárky

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: diabetes mellitus; lower extremity artery disease; red blood cell aggregation, transcutaneous partial tissue oxygen pressure

Online: 1 June 2023 (02:41:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0212.v1

Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Chiara Rossi, Anna Fernàndez, Pascual Torres, Omar Ramirez-Nuñez, Ana Belén Granado-Serrano, Mònica Povedano, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TDP-43; Jun; REST; ERK; mitochondria; cell stress; aggregation; transcription factors; transgenic mice; subcellular fractionation

Online: 9 July 2021 (10:14:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0275.v2

Exploiting Read/Write Asymmetry to Achieve Opportunistic SRAM Voltage Switching in Dual-Supply Near-Threshold Processors

Yunfei Gu, Dengxue Yan, Vaibhav Verma, Pai Wang, Mircea R. Stan, Xuan Zhang

Subject: Engineering, Electrical And Electronic Engineering Keywords: near threshold computing (NTC); dual-supply; static random access memory (SRAM); reliability; write aggregation buffer

Online: 5 September 2018 (05:45:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0118.v1

Interfacial and Bending Properties by Adding HNTs on the Aramid/Basalt Reinforced Epoxy-Based Hybrid Composites

Jin-Woo LEE, Tianyu Yu, Chang-Wook Park, Yun-Hae Kim

Subject: Chemistry And Materials Science, Nanotechnology Keywords: halloysite nanotube(HNT); hybrid composite; aramid fiber; basalt fiber; interfacial property; fiber reinforced composite; aggregation

Online: 16 May 2017 (07:39:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0031.v2

The Solvency II Standard Formula, Linear Geometry, and Diversification

Joachim Paulusch

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Solvency II; Standard Formula; Risk Measure; Diversification; Aggregation; Monotony; Homogeneity; Subadditivity; Euler's Principle; Capital Allocation

Online: 1 March 2017 (08:53:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1778.v1

Modeling and Simulation of Piezoelectric-Based Train-Induced Vibration Energy Harvester Railway Track Monitoring System

Shuvojit Kundu, Tuhel Ahmed, Jia Uddin

Subject: Safety, Risk, Reliability And Quality, Engineering Keywords: COMSOL Multiphysics; energy harvester; train-induced vibration; railway track monitoring

Online: 26 April 2024 (20:05:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0039.v1

The Healing Power of Plants: Herbal Compounds as Guardians against Antiretroviral and Antitubercular Drugs-Induced Hepatotoxicity

Raghu Ramanathan

Subject: Biology And Life Sciences, Toxicology Keywords: Medicinal Plants; Hepatoprotection; Hepatotoxicity; ARV; ATD; Drug-induced liver toxicity

Online: 1 April 2024 (10:59:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0691.v1

Protein Estimation and Toxicity Determination of Two Fractions of Pakistani Origin Naja oxiana Venom and Its Anti-inflammatory Assay by ROS, TNF-α and IL-β

Farah Aslam, Noor Jahan, Faheema Siddiqui, Mehtab Alam, Meh Jabeen, Nazia Ahmed, Saima Mahmood, Waqas Ahmed Farooqui

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Naja oxiana; anti-inflammatory; carrageenan induced peritonitis; Toxicity testing; LD50

Online: 12 March 2024 (10:04:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0282.v1

Modeling Pandemic Vaccine with Saturated Incidence Rate Based on Disease Induced Death

Odriozola Vazquez

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Vaccine; Basic Reproduction Number; Stabilities; Disease induced death; saturation terms

Online: 5 March 2024 (16:09:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2019.v1

Quantitative Analysis of Collagen and Apoptosis Related Protein on 1064 nm Laser-Induced Skin Injury

Qiong Ma, Yingwei Fan, Yufang Cui, Zhenkun Luo, Hongxiang Kang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: infrared laser; laser-induced skin wound; collagen; apoptosis related protein

Online: 29 January 2024 (10:31:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0895.v1

Circadian Rhythm Perturbation Aggravates Gut Microbiota Dysbiosis in Dextran Sulfate Sodium-Induced Colitis in Mice

Joseph Amara, Tarek Itani, Joelle Hajal, Jules-Joel Bakhos, Youakim Saliba, Saied A. Aboushanab, Elena G. Kovaleva, Nassim Fares, Alicia C. Mondragon, Jose Manuel miranda lopez

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: DSS-induced colitis; Dysbiosis; Circadian rhythm; Bacterial diversity; Microbiota; Gut

Online: 11 January 2024 (11:27:26 CET)

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Circadian rhythm disruption is increasingly considered an environmental risk factor for the development and exacerbation of inflammatory bowel disease. We have reported in a previous study that nychthemeral dysregulation is associated with an increase in intestinal barrier permeability and inflammation in mice with dextran sulfate sodium (DSS)-induced colitis. To investigate the effect of circadian rhythm disruption on the composition and diversity of the gut microbiota (GM). Sixty male C57BL/6J mice were divided initially to two groups, the shifted group (n=30) exposed to circadian shifts for three months and the non-shifted group (n=30) under a normal light-dark cycle. The mice of the shifted group were cyclically housed for five days under the normal 12:12 hour light-dark cycle followed by another five days under reversed light-dark cycle. At the end of the three months a colitis was induced by 2 % DSS given in the drinking water of 30 mice. Animals were then divided into four groups (n=15 per group), sham group non-shifted (Sham-NS), sham group shifted (Sham-S) and DSS non-shifted (DSS-NS) and DSS shifted (DSS-S). Fecal samples were collected from rectal content to investigate changes in GM composition by DNA extraction followed by high-throughput sequencing of the bacterial 16S rRNA gene. The mouse GM was dominated by three phyla: Firmicutes, Bacteroidetes and Actinobacteria. The Firmicutes/Bacteroidetes ratio decreased in mice with induced colitis. The richness and diversity of the GM were reduced in the colitis group, especially in the group with inverted circadian rhythm. Moreover, GM composition was also modified in the inverted circadian rhythm group, with an increase in Alloprevotella, Turicibacter, Bacteroides and Streptococcus genera. Circadian rhythm inversion exacerbates GM dysbiosis to a less rich and diversified extent in a DSS-induced colitis model. These findings shows a possible interplay between circadian rhythm disruption, GM dynamics, and colitis pathogenesis.

Preprint ARTICLE | doi:10.20944/preprints202312.1436.v1

siRNA-mediated BmAurora B depletion impedes the formation of holocentric square spindles in silkworm metaphase BmN4 cells

Bing Zhang, Camilo Ayra-Pardo, Xiao-Ning Liu, Mei-Ting Song, Dan-Dan Li, Yun-Chao Kan

Subject: Biology And Life Sciences, Insect Science Keywords: Bombyx mori; Chromatin-induced spindle assembly; siRNA; cell division; mitosis

Online: 19 December 2023 (11:35:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1938.v1

Drug-induced Anaphylaxis: National Database Analysis

Olga Butranova, Sergey Zyryanov, Anastasia Gorbacheva, Irina Asetskaya, Vitaly Polivanov

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: drug-induced allergy; anaphylaxis; antibiotics; local anesthetics; cyclooxygenase (COX)-inhibitors

Online: 30 November 2023 (04:21:45 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202309.1607.v1

New Nonlinear Coupled Model for Modeling the Vortex Induced Vibrations of Flexibly Supported Circular Cylinders

Shujun Zhang, Aref Afsharfard, Guanbin Chen, Wen-Li Chen, Kyung Chun Kim

Subject: Engineering, Mechanical Engineering Keywords: Vortex-Induced vibration; Wake oscillator equation; Numerical simulation; Nonlinear modeling

Online: 25 September 2023 (13:04:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1519.v1

Colchicine-Induced Polyploidy in Leguminous Crops Enhances Morpho-Physiological Characteristics for Drought Stress Tolerance

Phetole Mangena, Pirtununia Mushadu

Subject: Biology And Life Sciences, Plant Sciences Keywords: colchicine; drought stress; legumes; morphological traits; physiological traits; induced polyploidy

Online: 22 September 2023 (06:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2123.v1

Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting

Ana Cristina Corrêa Figueira, Ana Pereira, Luis Leitão, Rita Ferreira, Paula Oliveira, José Duarte

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Breast tumor; exercise training; gastrocnemius; soleus; cancer-induced muscle wasting

Online: 31 August 2023 (09:36:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2147.v1

Core Fucosylation Mediated by the FucT-8 Enzyme Affects Trail-Induced Apoptosis and Sensitivity to Chemotherapy in Human SW480 and SW620 Colorectal Cancer Cells

Rubén López-Cortés, Isabel Correa Pardo, Laura Muinelo-Romay, Almudena Fernández-Briera, Emilio Gil-Martín

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: FUT8 knockdown; core fucosylation; TRAIL-induced apoptosis; DR4; colorectal cancer

Online: 30 June 2023 (02:17:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1691.v1

Influence of Key Strata on the Evolution Law of Mining-induced Stress in the Working Face of Deep and Large-scale Mining

Jianlin Xie, Shan Ning, Weibing Zhu, Xiaozhen Wang, Tao Hou

Subject: Engineering, Mining And Mineral Processing Keywords: key strata; mining-induced stress; DOFS; 3DEC; large-scale mining

Online: 23 June 2023 (14:09:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0859.v1

Foliar Application of Chitosan Accelerates Wound Periderm Formation with an Intensified Deposition of Suberin Polyphenolics and Lignin at the Wound Site in Potato Tubers

Yan Zhu, Wei Zhang, Yuan Shou Zhao, Fu Chen, Fu peng Zhu, Ji peng Yang, Xiang zhen Ge, Wen juan Gong, Rui tong Cui, Wen jun Sheng

Subject: Biology And Life Sciences, Horticulture Keywords: chitosan; foliar application; lignin; potato; suberin polyphenolics; wound-induced suberization

Online: 11 May 2023 (13:35:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0160.v1

Hiit Induces Acute Inflammatory Profile in Older Adults In-Volving Il-17 and Il-10 Secretion: A Randomized Controlled Trial Study

Fabiana Rodrigues Scartoni, Diego Augusto Santos Silva, Andrea Carmem Guimarães, Brisa D'Louar Costa Maia, Estevao Scudese, Fabio Nascimento Da Silva, Delson Lustosa Figueiredo, Divaldo Martins de Souza, Carlos Soares Pernambuco, Rayana Nascimento Matos, Elizabeth Carvalho Lugão, Angela Maria Moed Lopes, Larissa Deadame Figueiredo-Nicolete, João Rafael Valentim-Silva

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Exercise; IL-17; IL-10; Interleukin. Exercise-Induced Inflammatory State

Online: 9 March 2023 (02:11:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0219.v1

Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized Psychiatry

Alessandra Alciati, Angelo Reggiani, Daniela Caldirola, Giampaolo Perna

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: personalized psychiatry; psychiatric disorders; induced pluripotent stem cells; brain organoids

Online: 14 July 2022 (11:46:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0068.v1

Mechanisms and Therapeutic Perspectives of Chemotherapy-Induced Peripheral Neuropathy: An Update

Antonio Avallone, Sabrina Bimonte, Claudia Cardone, Cira Antonietta Forte, Marco Cascella, Arturo Cuomo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Chemotherapy-induced peripheral neuropathy; pain management; target therapy; immuno-therapy

Online: 6 May 2022 (09:14:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0361.v1

Monitoring the Microseismicity through a Dense Seismic Array and a Similarity Search Detection Technique: Application to the Gas-Storage Site of Collalto, North Italy

Antonio Scala, Guido Maria Adinolfi, Matteo Picozzi, Francesco Scotto di Uccio, Gaetano Festa, Grazia De Landro, Enrico Priolo, Stefano Parolai, Rosario Riccio, Marco Romanelli

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Induced seismicity Monitoring; seismic arrays; sensor network technology; microearthquake detection

Online: 28 March 2022 (11:12:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0408.v1

Temporary Immersion System Improves Regeneration of in vitro Irradiated Recalcitrant Rice Embryogenic Calli

Alejandro Hernández-Soto, Jason Pérez-Chávez, Rebeca Fait-Zuñiga, Randall Rojas-Vásquez, Andres Gatica-Arias, Ana Abdelnour-Esquivel

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Embryogenesis; Cobalt-60 radiation-induced mutagenesis; Temporary immersion systems (TIS).

Online: 24 December 2021 (14:47:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0082.v1

Exogenous Application of Methyl Jasmonate Increases Emissions of Volatile Organic Compounds in Pyrenean Oak Trees, Quercus pyrenaica

Luisa Amo, Anna Mrazova, Irene Saavedra, Katerina Sam

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Avian olfaction; foraging; herbivore-induced plant volatiles; defence against herbivory

Online: 6 December 2021 (15:21:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0031.v1

Development of a Microfluidic Platform for Trace Lipid Analysis

Andrew Davic, Michael Cascio

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: primary fatty acid amides; microfluidics; laser induced fluorescence, bioactive lipids

Online: 2 October 2020 (09:16:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0052.v1

Optical Damage Thresholds of Microstructures Made by Laser 3D Nanolithography

Agnė Butkutė, Laurynas Čekanavičius, Gabrielius Rimšelis, Darius Gailevičius, Vygantas Mizeikis, Andrius Melninkaitis, Tommaso Baldacchini, Linas Jonušauskas, Mangirdas Malinauskas

Subject: Physical Sciences, Optics And Photonics Keywords: 3D laser lithography; laser induced damage threshold; micro-optics; photonics

Online: 4 October 2019 (11:56:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0001.v1

Variable Cant Angle Winglets for Improvement of Aircraft Flight Performance

Joel Guerrero, Kevin Wittkowski, Marco Sanguineti

Subject: Engineering, Aerospace Engineering Keywords: Variable cant angle; Winglets; Drag reduction; Lift-induced drag; CFD

Online: 1 July 2019 (11:02:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0175.v1

Numerical and Experimental Analyses of Three-Dimensional Unsteady Flow Around a Micro-Pillar Subjected to Rotational Vibration

Kanji Kaneko, Takayuki Osawa, Yukinori Kametani, Takeshi Hayakawa, Yosuke Hasegawa, Hiroaki Suzuki

Subject: Engineering, Mechanical Engineering Keywords: vibration-induced flow; micro-pillar; numerical analysis; micro-PIV; acoustofluidics

Online: 7 November 2018 (14:57:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0376.v1

Self-Absorption Analysis of Silver Resonance Lines in Nano-Material Laser Produced Plasma

Ashraf M. El Sherbini, Mohamed A. Hagras , Mohamed R. Rizk , El-Sayed A. El Badawy, Christian G. Parigger

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: laser-induced plasma; atomic spectroscopy; self-absorption; nanoparticles; silver; hydrogen

Online: 20 July 2018 (05:49:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0282.v1

Influence of Single Fracture Inclination on Fault Activation

Yujie Zhu, Xiaoli Liu, Enzhi Wang, Sijing Wang, Jianwen Zhong

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: hydraulic fracturing; hollow cylinder; single fracture; fault activation; induced seismicity

Online: 22 May 2018 (05:04:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1162.v2

Structural Variations of Prions and Prion-Like Proteins Associated with Neurodegeneration

Carter Sky Christensen, Wenshu Li, Danyang Yu, Henry James Li

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: prions; neurodegeneration; Alzheimer’ s disease; protein homeostasis; aggregation; prion-like proteins; amyloid beta; hyperphosphorylated tau; self replication

Online: 19 December 2023 (09:42:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0586.v1

Harbor Porpoise Aggregations in the Salish Sea

Dave Anderson, Laurie Shuster, Cindy R. Elliser, Katrina MacIver, Erin Johns Gless, Johannes Krieger, Anna Hall

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: harbor porpoise; aggregation; social behavior; Phocoena phocoena; foraging behavior; large group; transboundary; community science; Salish Sea

Online: 8 June 2023 (04:18:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1403.v1

Liposome Nanoparticle Conjugation and Cell Penetrating Peptide Sequences (CPPs) Enhance the Cellular Delivery of the Tau Aggregation Inhibitor RI-AG03

Niklas Reich, David Allsop, Edward Parkin, Neil Dawson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s Disease; Tauopathy; Cell penetrating peptide; Polyarginine; TAT; Liposomes; Nanoparticles; Tau pathology; Tau aggregation inhibitor; Endocytosis

Online: 19 May 2023 (08:06:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0376.v1

Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies

JIngwen Jiang, Yu Liu, Qihui Wu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; Parkinson’s disease; Aβ cascade hypothesis; a-synuclein aggregation and spreading; transcriptomics of nervous system

Online: 22 September 2021 (11:33:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0142.v1

Simultaneous Occurrence of Bioactive Compounds (Melatonin, Protocatechuic Acid and Hydroxytyrosol) Increases Their Neuroprotective Effects Against Alpha-Synuclein-Induced Proteotoxicity

Marta Gallardo-Fernández, Ruth Hornedo-Ortega, Ana B Cerezo, Ana M Troncoso, Mª Carmen Garcia-Parrilla

Subject: Biology And Life Sciences, Toxicology Keywords: melatonin, protocatechuic acid, hydroxytyrosol, α-synuclein, toxicity, amyloid aggregation, neurodegeneration, Parkinson´s disease, olive oil, wine

Online: 6 November 2018 (13:09:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0396.v1

Modeling the Separation of Microorganisms in Bioprocesses by Flotation

Stefan Schmideder, Christoph Kirse, Julia Hofinger, Sascha Rollié, Heiko Briesen

Subject: Engineering, Bioengineering Keywords: flotation; separation of microorganisms; bioseparation; heteroaggregation; population balance modeling; coupling of aggregation and CFD; model comparison

Online: 22 August 2018 (11:58:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0405.v1

Heronian Means as Aggregation Operators for Multi-Attribute Decision Making Applications

Xiaopu Shang, Jun Wang, Anupam Nanda, Weizi Li

Subject: Computer Science And Mathematics, Mathematics Keywords: interval-valued intuitionistic fuzzy set; aggregation operator; Heronian mean; geometric Heronian mean; multi-attribute decision making

Online: 23 July 2018 (05:29:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1590.v1

How to Cristallize a Glass with a Femtosecond Laser

Ruyue QUE, Matthieu Lancry, Maxime Cavillon, Bertrand Poumellec

Subject: Other, Engineering Keywords: laser induced crystallization in glass; crystallization of oxyde glasses; femtosecond laser

Online: 24 April 2024 (08:28:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1231.v1

Suppression of Ventilation-Induced Diaphragm Fibrosis through the Phosphoinositide 3-Kinase-γ in a Murine Bleomycin-Induced Acute Lung Injury Medel

Li-Fu Li, Chung-Chieh Yu, Chih-Yu Huang, Huang-Pin Wu, Chien-Ming Chu, Ping-Chi Liu, Yung-Yang Liu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: apoptosis; diaphragm fibrosis; phosphoinositide 3-kinase-g; ventilator-induced diaphragm dysfunction

Online: 18 April 2024 (10:06:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1320.v1

Carbon Dots Synthesis in CYTOP Optical Fiber Using IR Femtosecond Laser Direct Writing and Its Luminescence Properties

Ruyue QUE, Jean-Frédéric Audibert, Enrique Garcia-Caurel, Olivier Plantevin, Kyriacos Kalli, Matthieu Lancry, Bertrand Poumellec, Robert B. Pansu

Subject: Physical Sciences, Optics And Photonics Keywords: CYTOP fiber; femtosecond laser; laser induced modification; photoluminescence creation; multifunctionnal material

Online: 22 March 2024 (04:48:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0570.v1

Earthquake-Induced Landslides in Italy: Evaluation of the Triggering Potential Based on Seismic Hazard

Sina Azhideh, Simone Barani, Gabriele Ferretti, Davide Scafidi

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: earthquake-induced landslides; landslide triggering; seismic hazard; hazard disaggregation; triggering probability.

Online: 11 March 2024 (17:47:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0962.v1

Clinical Variables and Peripheral Biomarkers Associated with Substance-Induced Psychotic Disorder: Which Differences between Alcohol, Cannabis and Psychostimulants?

Martina Di Paolo, Antonia Calabrese, Guido Nosari, Valentina Ciappolino, Luisa Cirella, Alice Caldiroli, Enrico Capuzzi, Massimo Clerici, Massimiliano Buoli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcohol; cannabis; clinical variables; peripheral biomarkers; psychostimulants; substance-induced psychotic disorder

Online: 19 February 2024 (14:34:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1433.v1

Degradation Models and Maintenance Strategies for Reinforced Concrete Structures in Coastal Environments under Climate Change: A Review

Luis F. Rincon, Yina M. Moscoso, Ameur El Amine Hamami, José C. Matos, Emilio Bastidas-Arteaga

Subject: Engineering, Civil Engineering Keywords: Chloride-induced corrosion; reinforcement concrete; degradation models; maintenance; monitoring; climate change

Online: 18 January 2024 (14:47:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1900.v1

2,4‐D Herbicide‐Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Rafael Xavier Martins, Matheus Carvalho, Maria Eduarda de Souza Maia, Bruno Flor, Terezinha Souza, Thiago Lopes Rocha, Luís Félix, Davi Farias

Subject: Biology And Life Sciences, Toxicology Keywords: drug induced liver injury, emerging contaminant, oxidative stress, water pollution, agrochemical.

Online: 29 November 2023 (15:18:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0634.v1

Experimental Study of the Train-Induced Vibration Propagation on Over-Track Buildings over Metro Depots

Yang Liu, Senlin Zheng, Haodong Xu

Subject: Engineering, Architecture, Building And Construction Keywords: Train-induced vibration; Over-track buildings; Sound comfort; Rail transit development

Online: 8 August 2023 (08:36:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2081.v1

Sequential and Simultaneous Interactions of Plant Allelochemical Flavone, Bt Toxin Vip3A and Insecticide Emamectin Benzoate in Spodoptera frugiperda

Kaiyuan Huang, Haibo He, Shan Wang, Min Zhang, Xuewei Chen, Zhongyuan Deng, Xinzhi Ni, Xianchun Li

Subject: Biology And Life Sciences, Insect Science Keywords: Allelochemical; Bt toxin; chemical insecticide; combined toxicity; induced toxicity; synergistic interactions

Online: 29 June 2023 (09:49:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0245.v1

Fracture Electromagnetic Radiation Induced by a Seismic Active Zone (in the Vicinity of Eilat City, Southern Israel)

Vladimir Frid, Avinoam Rabinovitch, Dov Bahat, Uri Kushnir

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: fracture-induced electromagnetic radiation (FEMR); FEMR field measurements; micro-fracturing, earthquakes

Online: 5 June 2023 (05:35:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0115.v1

Functional Characterization of Candidate Genes, Gohir.D05G103700 and Gohir.D12G153600, Identified Through the Expression QTL Analysis using Virus Induced Gene Silencing in Upland Cotton (Gossypium hirsutum L.)

Salman Naveed, Sachin Rustgi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Cotton; virus-induced gene silencing; plant architecture; expression QTL; candidate gene

Online: 7 April 2023 (05:30:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0436.v1

Co-Precipitation of CD, Cr, Pb, Zn, and Carbonates Using Vibrio harveyi Strain Isolated From Mediterranean Sea Sediment

Mazhar Ali Jarwar, Pablo Del Buey, M Esther Sanz-Montero, Stefano Dumontet, Elena Chianese, Vincenzo Pasquale

Subject: Environmental And Earth Sciences, Pollution Keywords: Heavy metals; microbially induced carbonate precipitation (MICP); co-precipitation; calcite; vaterite

Online: 27 March 2023 (03:26:14 CEST)

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Working Paper ARTICLE

Roles of Sirtuins in the Protection against Cisplatin Ototoxicity

Xiaodong Tan, Yingjie Zhou, Alan Robinson, Shreya Sriram, Claus-Peter Richter

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Drug-induced hearing loss; cochlea; outer hair cells; hearing protection; SIRT3

Online: 9 August 2021 (07:50:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0565.v1

Inhibition of cAMP/PKA/CREB Signaling Axis Improves Fibroblast Plasticity for Direct Cardiac Reprogramming

Emre Bektik, Yu Sun, Adrienne Dennis, Phraew Sakon, Dandan Yang, Jidong Fu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: induced cardiomyocyte; epigenetic reprogramming; heart regeneration; cell plasticity; transdifferentiation; CREB-CBP

Online: 21 April 2021 (09:39:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0242.v1

Extracellular Vesicles: The New Frontier of Stem Cell Regenerative Medicine?

Maria Magdalena Barreca, Patrizia Cancemi, Fabiana Geraci

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: extracellular vesicles; stem cells; induced pluripotent stem cells (iPSCs); regenerative medicine

Online: 15 April 2020 (10:08:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0013.v1

Tracking Temporal Development of Optical Thickness of Hydrogen Alpha Spectral Radiation in a Laser Induced Plasma

David M. Surmick, Christian G. Parigger

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: atomic spectroscopy; radiation transfer; hydrogen; laser-induced breakdown spectroscopy; stark broadening

Online: 2 October 2019 (03:42:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0028.v1

Hypoglycemic, Antiglycation and Cytoprotective Properties of A Phenol Rich Extract from Waste Peel of Punica Granatum L. Var. Dente Di Cavallo DC2

Antonella Di Sotto, Marcello Locatelli, Alberto Macone, Chiara Toniolo, Stefania Cesa, Simone Carradori, Margherita Eufemi, Gabriela Mazzanti, Silvia Di Giacomo

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: vegetable waste; phenolics; hyperglycemia-induced oxidative stress; antioxidant activity; AGE inhibition

Online: 2 August 2019 (10:36:17 CEST)

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Working Paper REVIEW

Corrective Metabolism: An Appreciation

Dan Fraenkel

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: metabolism; metabolic by products; overflow; damage; toxicity; repair; geneticist-induced stress

Online: 20 June 2019 (10:10:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0521.v1

The Role of Golgi Morphology in Post-Alcohol Recovery of Hepatocytes: Observations in Cellular and Animal Models

Carol A. Casey, Paul Thomes, Sonia Manca, Armen Petrosyan

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: alcohol-induced Golgi disorganization; Golgi recovery; giantin; hepatic proteins; ethanol withdrawal

Online: 23 October 2018 (06:10:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0106.v1

The Diagnostic Value of HIF-2 Alpha to Determine The Development and Efficacy of Treatment for Contrast Induced Nephropathy: An Experimental Study

Ismail Altintop, Mehmet Tatli, Cigdem Karakukcu, Zeynep Soyer Sarica, Arzu Hanım Yay, Esra Balcioglu, Ahmet Ozturk

Subject: Medicine And Pharmacology, Pharmacy Keywords: contrast-induced nephropathy; hypoxia-inducible factor 2α; N-acetyl-cysteine; sildenafil

Online: 7 May 2018 (08:15:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0253.v1

Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip

Yang Jun Kang

Subject: Engineering, Bioengineering Keywords: Erythrocyte sedimentation rate (ESR); shear stress index; Aggregation index; Blood shear stress; Blood flow intensity; Capillary chip

Online: 5 July 2023 (08:55:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1796.v1

Current Status of Cardiac Regenerative Therapy Using Induced Pluripotent Stem Cells

Tadahisa Sugiura, Dhienda C Shahannaz, Brandon E Ferrell

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Cardiac regenerative therapy; induced pluripotent stem cell; stem cell therapy; heart failure

Online: 28 April 2024 (08:09:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0962.v1

Bovine Pluripotent Stem Cells: Current Status and Prospects

Lan-Xin Chen, Bo Tang, Guang-Hong Xie, Rui Yang, Bo-Yang Zhang, Yue-Qi Wang, Yan Zhang, Dao-Zhen Jiang, Xue-Ming Zhang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: cattle; embryonic stem cells; potential stem cells; induced pluripotent stem cells; reprogramming

Online: 13 December 2023 (09:18:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0747.v1

A Deep Learning Approach for Automated Classification of Geomagnetically Induced Current Scalograms

Tatyana Aksenovich, Vasiliy Selivanov

Subject: Engineering, Electrical And Electronic Engineering Keywords: geomagnetically induced currents; autotransformer; continuous wavelet transform; convolutional neural network; binary classification

Online: 12 December 2023 (05:22:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1662.v1

Preventive Effect of Ecklonia cava Extract on Dss-Induced Colitis by Elevating Intestinal Barrier Function and Improving Pathogenic Inflammation

Young-Mi Kim, Hye-Youn Kim, Ji Tae Jang, Suntaek Hong

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Ecklonia cava extract; DSS-induced colitis; Intestinal barrier; Pathogenic inflammation

Online: 27 November 2023 (11:21:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0916.v2

Flutter of a Plate at High Supersonic Speeds

Aziz Sezgin, Birkan Durak, Alaattin Sayın, Huseyin Yildiz, Hasan Omur Ozer, Lutfi Emir Sakman, Sule Kapkin, Erol Uzal

Subject: Engineering, Mechanical Engineering Keywords: Flutter velocity; Flow-induced plate vibration; Piston Theory; Collocation Method; Shooting Method

Online: 22 November 2023 (07:44:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1599.v1

Corrosion Failure Analysis of Duplex Stainless Steel Used as Shell and Tube Heat Exchanger with Seawater as the Cooling Medium

Husaini Ardy, Thomas Albatros, Afriyanti Sumboja

Subject: Engineering, Mechanical Engineering Keywords: Microbial Induced Corrosion; Failure Analysis; Heat Exchanger Failures; Crevice Corrosion; Seawater Corrosion

Online: 23 May 2023 (07:41:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1313.v1

Flexible Micro-Structured Capacitive Pressure Sensors by Laser Engraving and Graphitization from Natural Wood

Chenkai Qu, Meilan Lu, Ziyan Zhang, Shangbi Chen, Dewen Liu, Dawei Zhang, Jing Wang, Bin Sheng

Subject: Chemistry And Materials Science, Paper, Wood And Textiles Keywords: laser induced graphene; flexible pressure sensor; micro-structures; capacitance sensors; laser engraving

Online: 18 May 2023 (09:35:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0597.v1

Laser-Induced Graphene on Optical Fibre: Towards Simple and Cost-Effective Electrochemical/Optical Lab-on-Fibre Bioplatforms

Rafael A. Ribeiro, Laura L. Ferreira, António J. S. Fernandes, Florinda Mendes Da Costa, Carlos Marques, Nuno F. Santos

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: 3D graphene; laser processing; laser-induced graphene; optical fibre; electrochemical sensors; dopamine

Online: 20 April 2023 (02:51:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0580.v1

The Fall Armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), Influences Nilaparvata lugens Population Growth Directly, by Preying on Its Eggs, and Indirectly, by Inducing Defenses in Rice

Chen Qiu, Jiamei Zeng, Yingying Tang, Qing Gao, Wenhan Xiao, Yonggen Lou

Subject: Biology And Life Sciences, Insect Science Keywords: herbivore-induced plant defense; signaling pathway; intraguild predation; jasmonoyl-isoleucine; abscisic acid

Online: 19 April 2023 (09:31:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0083.v1

Combination Therapy of Irreversible Electroporation and Cytokine-Induced Killer Cells for Treating Mice Bearing Panc02 Pancreatic-Cancer Xenografts

Baohua Wang, Huiyang Wang, Lan Yue, Qiang Chen, Junjie Dong, Tian'an Jiang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Irreversible electroporation; Cytokine-induced killer cells; Combination therapy; Pancreatic cancer; Chemokine receptors

Online: 6 December 2022 (01:31:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0459.v1

Phenylbenzohydrazides Obtained from Isatoic Anhydride Present Anti-Inflammatory Activity in Vivo and in Vitro

João Pedro Barros de Paiva, Millena Santos Cordeiro, Patricia Ribeiro de Carvalho França, Luiz Octavio Pereira Branco, Isabela Souza dos Santos, Nanashara Figueiredo Reis, Patrick Pedro Pimentel, Thais Biondino Sardella Giorno, Evanoel Crizanto de Lima, Patricia Dias Fernandes

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Phenylbenzohydrazides; isatoic anhydride; inflammation; anti-inflammatory substance; carrageenan-induced inflammation; nitric oxide

Online: 31 October 2022 (01:02:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0060.v1

An Investigation of Surface Stress on the Fracture Mechanics Behavior of Classical and Phase-Separating Planar Electrodes

Seyed Ali Mahmoudy, Hamed Haftbaradaran

Subject: Engineering, Mechanical Engineering Keywords: Lithium-ion batteries; phase-separation; fracture mechanics; surface stress; diffusion-induced stresses

Online: 3 November 2021 (08:07:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0552.v1

Cerebral Organoids Derived from a Parkinson’s Patient Exhibit Unique Pathogenesis from Chikungunya Virus Infection when Compared to a Non-Parkinson’s Patient

Emily Schultz, Tyanthony Jones, Sibei Xu, Dana Dean, Bernd Zechmann, Kelli L. Barr

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: organoid; induced pluripotent stem cell; Parkinson’s disease; neurotransmission; neuroimmunity; neuroinflammation; chikungunya; neuroinvasive

Online: 27 January 2021 (10:31:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0480.v1

Differences between Cerebral Organoids Derived from a non-PD and a Parkinson’s Patient: A Potential Vulnerability for Neuroinvasive Viruses

Emily Schultz, Tyanthony Jones, Sibei Xu, Dana Dean, Bernd Zechmann, Shannon Ronca, Kelli L. Barr

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: organoid; induced pluripotent stem cell; Parkinson’s disease; neurotransmission; neuroimmunity; neuroinflammation; viral infection

Online: 25 January 2021 (10:55:03 CET)

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The development of 3D cerebral brain organoids which accurately resemble aspects of the human brain permits a more accurate characterization of physiological processes and neurological diseases. Cerebral organoids can be grown from stem cell lines with various genetic backgrounds allowing multiple neurodegenerative diseases to be modeled. While dysfunction in neurotransmission of patients with neurodegenerative diseases is expected, the impact of chronic neurodegeneration on the response to viral infection of the CNS is poorly understood. For instance, several mosquito-borne viruses like Dengue virus and West Nile Virus cause post-viral parkinsonism. How CNS infection might impact a host with inherent CNS dysfunction such as Parkinson’s Disease in poorly understood. This preliminary, observational study aimed to understand dysfunction in intrinsic and innate expression of a patient with a neurodegenerative disease and a non-affected individual in relation to potential viral infection in the CNS. Cerebral organoids were generated from human induced pluripotent stem cells with a normal genetic background or with idiopathic Parkinson’s Disease. After differentiation and maturation, organoid size, gene expression and immunofluorescence were evaluated to assess neurotransmission and innate immunity. While there was no significant difference in size of the organoids with a normal or Parkinson’s genetic background, gene expression studies identified multiple differences in innate immunity and neurotransmission. Immunofluorescence also identified differences in protein expression related to neurotransmission and innate immunity. Of note, organoids derived from a Parkinson’s patient exhibited endogenous up-regulation of dopamine and muscarinic acetylcholine receptors, GABA, glycine, and glutamate targets, and the majority of cytokines. This expression pattern suggests a chronic state of neuroexcitation and neuroinflammation in this population of organoids.

Preprint ARTICLE | doi:10.20944/preprints202101.0316.v1

Valproic Acid-Induced Liver Injury: A Case-Control Study from a Prospective Pharmacovigilance Program in a Tertiary Hospital

Enrique Seco Meseguer, Mikel Urroz Elizalde, Alberto M. Borobia, Elena Ramírez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Valproic acid; Drug-induced liver injury; Adverse drug reaction; Case-control study

Online: 18 January 2021 (11:11:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0028.v1

Pore Pressure Analysis for Distinguishing Earthquakes Induced by CO2 Injection from Natural Earthquakes

Chanmaly Chhun, Takeshi Tsuji

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: pore pressure; CO2 injection; induced earthquakes; seasonal earthquakes; remote earthquakes; seismogenic faults

Online: 2 November 2020 (11:17:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0027.v1

Space-Selective Control of Functional Crystals by Femtosecond Laser: a Comparison Between SrO-TiO₂-SiO₂and Li₂O-Nb₂O₅-SiO₂ Glasses

He Xuan, Liu Qiming, Lancry Matthieu, Brisset François, Poumellec Bertrand

Subject: Chemistry And Materials Science, Biomaterials Keywords: femtosecond laser-induced crystallization; nonlinear crystals; controllable texture; fresnoite; Sr2TiSi2O8; LiNbO3; glass

Online: 1 October 2020 (18:40:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0166.v1

Study of Local Inertial Focusing Conditions for Spherical Particles in Asymmetric Serpentines

Eric Pedrol, Jaume Massons, Francesc Díaz, Magdalena Aguiló

Subject: Physical Sciences, Applied Physics Keywords: inertial focusing; serpentine; dean; inertial force; shear gradient-induced; wall effect; vortex

Online: 15 November 2019 (03:37:41 CET)

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