Figueira, A.C.C.; Pereira, A.; Leitão, L.; Ferreira, R.; Oliveira, P.A.; Duarte, J.A. Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting. Healthcare2023, 11, 2652.
Figueira, A.C.C.; Pereira, A.; Leitão, L.; Ferreira, R.; Oliveira, P.A.; Duarte, J.A. Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting. Healthcare 2023, 11, 2652.
Figueira, A.C.C.; Pereira, A.; Leitão, L.; Ferreira, R.; Oliveira, P.A.; Duarte, J.A. Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting. Healthcare2023, 11, 2652.
Figueira, A.C.C.; Pereira, A.; Leitão, L.; Ferreira, R.; Oliveira, P.A.; Duarte, J.A. Effects of Moderate Exercise Training on Cancer-Induced Muscle Wasting. Healthcare 2023, 11, 2652.
Abstract
Background: Muscle wasting is a common phenomenon in oncology and appears to be alleviated by exercise training. This study aims to determine the degree of aggressiveness of cancer-induced muscle wasting in two different phenotypic muscles, and whether exercise training can attenuate this muscle dysfunction. Methods: Fifty Sprague-Dawley rats were randomly assigned to four experimental groups, two control groups (sedentary and exercised) and two breast cancer model groups (sedentary and exercised) induced by 1-methyl-1-nitrosoureia (MNU). After 35 weeks of endurance training the animals were sacrificed and the gastrocnemius and soleus muscles were harvested for morphometric analysis. Results: A significant reduction in cross-sectional area (P < 0.05) was found in both muscles of sedentary tumor-bearing animals. Interstitial fibrosis was significantly higher in the gastrocnemius of sedentary tumor-bearing animals (P < 0.05), but not in the soleus. A shift from large to small fibers was observed in the gastrocnemius of sedentary tumor-bearing animals. Long-term exercise training was able to prevent this cancer-related mus-cle dysfunction. Conclusions: The Gastrocnemius muscle showed a very pronounced reduction in cross-sectional area and marked interstitial fibrosis in sedentary animals with tumors. The soleus muscle showed a less pronounced but significant reduction in cross-sectional area, and collagen deposition did not differ between tumor groups. These contrasting results confirm that can-cer-induced muscle wasting can affect specific fiber types, and specific muscles, namely fast glycolytic muscles, and that exercise training can act to improve it.
Keywords
Breast tumor; exercise training; gastrocnemius; soleus; cancer-induced muscle wasting
Subject
Public Health and Healthcare, Physical Therapy, Sports Therapy and Rehabilitation
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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