Version 1
: Received: 21 September 2021 / Approved: 22 September 2021 / Online: 22 September 2021 (11:33:22 CEST)
How to cite:
Jiang, J.; Liu, Y.; Wu, Q. Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies. Preprints2021, 2021090376. https://doi.org/10.20944/preprints202109.0376.v1
Jiang, J.; Liu, Y.; Wu, Q. Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies. Preprints 2021, 2021090376. https://doi.org/10.20944/preprints202109.0376.v1
Jiang, J.; Liu, Y.; Wu, Q. Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies. Preprints2021, 2021090376. https://doi.org/10.20944/preprints202109.0376.v1
APA Style
Jiang, J., Liu, Y., & Wu, Q. (2021). Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies. Preprints. https://doi.org/10.20944/preprints202109.0376.v1
Chicago/Turabian Style
Jiang, J., Yu Liu and Qihui Wu. 2021 "Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies" Preprints. https://doi.org/10.20944/preprints202109.0376.v1
Abstract
Alzheimer’s and Parkinson's diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (Aβ) and α-synuclein are two of the most investigated proteins, whose pathological aggregation and spreading are crucial to the pathogenesis of AD and PD, respectively. Transcriptomic studies of the mammalian central nervous system shed light on gene expression profiles at molecular levels, regarding the complexity of neuronal morphologies and electrophysiological inputs/outputs. In the last decade, the booming of the single-cell RNA sequencing technique helped to understand gene expression patterns, alternative splicing, novel transcripts, and signal pathways in the nervous system at single-cell levels, providing insight for molecular taxonomy and mechanistic targets of the degenerative nervous system. Here, we re-visited the cell-cell transmission mechanisms of Aβ and α-synuclein in medi-ating disease propagation, and summarized recent single-cell transcriptome sequencing from different perspectives and discussed its understanding of neurodegenerative diseases.
Keywords
Alzheimer’s disease; Parkinson’s disease; Aβ cascade hypothesis; a-synuclein aggregation and spreading; transcriptomics of nervous system
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
