Kang, Y.J. Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip. Micromachines2023, 14, 1594.
Kang, Y.J. Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip. Micromachines 2023, 14, 1594.
Kang, Y.J. Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip. Micromachines2023, 14, 1594.
Kang, Y.J. Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip. Micromachines 2023, 14, 1594.
Abstract
Blood image intensity has been used to detect erythrocyte sedimentation rate (ESR). However, it does not give an information on biophysical properties of blood sample under continuous ESR. In this study, three physical properties, including, τ0, ESRτ, and AII, are suggested to quantify mechanical variations of blood under continuous ESR. To demonstrate the proposed method, blood sample is loaded into a driving syringe. The blood flow rate is set in a periodic on–off pattern. Blood sample is then supplied into a capillary chip, and microscopic blood images are captured at specific intervals. Blood shear stress is quantified from the interface of blood stream in the coflowing channel. Both τ0 and ESRτ are then obtained by analyzing the blood shear stress. Simultaneously, the AII is evaluated by analyzing the image intensity of blood flow. According to the experimental results, the τ0 exhibits consistent trends with respect to hematocrit as well as diluent. The ESRτ and AII showed a reciprocal relationship each other. Three suggested properties represented substantial differences for suspended blood samples (i.e., hardened red blood cells, different concentration of dextran solution and fibrinogen). In conclusion, the present method can detect variations of blood sample under continuous ESR effectively.
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