Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Hiit Induces Acute Inflammatory Profile in Older Adults In-Volving Il-17 and Il-10 Secretion: A Randomized Controlled Trial Study

Fabiana Rodrigues Scartoni
,
Diego Augusto Santos Silva
,
Andrea Carmem Guimarães
,
Brisa D'Louar Costa Maia
,
Estevao Scudese
,
Fabio Nascimento Da Silva
ORCID logo ,
Delson Lustosa Figueiredo
,
Divaldo Martins de Souza
ORCID logo ,
Carlos Soares Pernambuco
,
Rayana Nascimento Matos
,
Elizabeth Carvalho Lugão
,
Angela Maria Moed Lopes
,
Larissa Deadame Figueiredo-Nicolete
,
João Rafael Valentim-Silva
*
Version 1 : Received: 5 March 2023 / Approved: 9 March 2023 / Online: 9 March 2023 (02:11:14 CET)

How to cite: Scartoni, F.R.; Silva, D.A.S.; Guimarães, A.C.; Maia, B.D.C.; Scudese, E.; Da Silva, F.N.; Figueiredo, D.L.; Martins de Souza, D.; Pernambuco, C.S.; Matos, R.N.; Lugão, E.C.; Lopes, A.M.M.; Figueiredo-Nicolete, L.D.; Valentim-Silva, J.R. Hiit Induces Acute Inflammatory Profile in Older Adults In-Volving Il-17 and Il-10 Secretion: A Randomized Controlled Trial Study. Preprints 2023, 2023030160. https://doi.org/10.20944/preprints202303.0160.v1. Scartoni, F.R.; Silva, D.A.S.; Guimarães, A.C.; Maia, B.D.C.; Scudese, E.; Da Silva, F.N.; Figueiredo, D.L.; Martins de Souza, D.; Pernambuco, C.S.; Matos, R.N.; Lugão, E.C.; Lopes, A.M.M.; Figueiredo-Nicolete, L.D.; Valentim-Silva, J.R. Hiit Induces Acute Inflammatory Profile in Older Adults In-Volving Il-17 and Il-10 Secretion: A Randomized Controlled Trial Study. Preprints 2023, 2023030160. https://doi.org/10.20944/preprints202303.0160.v1.

Abstract

Here we investigated the acute effects of an exhaustive intermittent exercise session on immunological parameters of the elderly and the subsequent incidence of upper respiratory tract infections and compare with the moderate-intensity. To do so, ixty-three old subjects were divided into three groups HIIT (n=21) submitted at one High-intensity interval training, SCG (n=21) kept in a sedentary state, and MICT (n=21) submitted at moderate intensity walking. Blood were collected at 5 time points, before, immediately after, 2h, 24h, and 48h after the intervention. In result the IL-6 and TNF-α were overexpressed immediately after the IL-10 stood overexpressed and correlated with IL-17, denoting an inflammatory process, and evidencing an immunologic competence without enhancement of the prevalence of upper respiratory infection tract (URTIs). So a modulation in the balance of Th1/Th2/Th17 cytokines and leukocytes, these modifications did not cause the effect characterized as an immunological window. Perhaps, the typical inflammation process, with IL-10 and IL-17 participation could also produce benefits to combat infections, a pertinent discussion during a post-pandemic time; we consider it a safe exercise program for older adults.

Keywords

Exercise; IL-17; IL-10; Interleukin. Exercise-Induced Inflammatory State

Subject

LIFE SCIENCES, Immunology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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