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Preprint ARTICLE | doi:10.20944/preprints202404.1418.v1

Cancer Incidence Rates for non-Hispanic White Men and Women in the US in 2016–2020 with Respect to Solar UVB Doses, Diabetes and Obesity Prevalence, Lung Cancer Incidence Rates, and Alcohol Consumption: An Ecological Study

William B. Grant

Subject: Other, Public Health And Healthcare Keywords: alcohol consumption; cancer incidence; diabetes mellitus; diet; ecological study; lung cancer; obesity; solar UVB, USA; vitamin D

Online: 23 April 2024 (11:48:24 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1412.v1

Bovine Parainfluenza Virus 3 and Bovine Respiratory Syncytial Virus: Dominant Viral Players in Bovine Respiratory Disease Complex among Serbian Cattle

Vesna Milićević, Sofija Šolaja, Dimitrije Glišić, Milan Ninković, Bojan Milovanović, Milan Đorđević, Snežana Ristevski, Filip Spasojević, Miroljub Dačić

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Bovine Respiratory Disease Complex; Bovine Viral Diarrhea Virus; Bovine Herpesvirus-1; Bovine Respiratory Syncytial Virus; Bovine Parainfluenza Virus 3; Influenza Virus D; prevalence; Serbia

Online: 22 April 2024 (12:55:09 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0739.v2

Could SP-A and SP-D Serum Levels Predict COVID-19 Severity?

Luca Maddaloni, Veronica Zullino, Ginevra Bugani, Alessandro Lazzaro, Matteo Brisciani, Claudio Mastroianni, Letizia Santinelli, Franco Ruberto

Subject: Virology, Biology And Life Sciences Keywords: SP-A; SP-D; SARS-CoV-2; collectins; surfactant proteins

Online: 19 April 2024 (15:21:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0996.v1

Simple Determination of Affinity Constants of Antibodies by Competitive Immunoassays

Janina Fischer, Jan Ole Kaufmann, Michael G. Weller

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ELISA; microplate; competitive immunoassay; IC₅₀; test midpoint; point of inflection; law of mass action; thermodynamics; equilibrium constant; dissociation constant; binding strength; monoclonal antibodies; clones; surface-plasmon resonance; SPR; interaction; isothermal titration calorimetry; ITC; microscale thermophoresis; MST; K_d value

Online: 16 April 2024 (11:08:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0546.v1

Companies with at Least 10 Employees Selling Online across the Italian Regions

Angelo Leogrande

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: Innovation; Innovation and Invention; Management of Technological Innovation and R&; D; Technological Change; Intellectual Property and Intellectual Capital

Online: 8 April 2024 (16:06:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0304.v1

The Impact of a 6-Week Nordic Walking Training Cycle and a 14-Hour Intermittent Fasting on Disease Activity Markers and Serum Levels of Wnt Pathway-Associated Proteins in Patients with Multiple Myeloma

Olga Czerwińska-Ledwig, Małgorzata Żychowska, Artur Jurczyszyn, Joanna Kryst, Jakub Mirosław Deląg, Andżelika Borkowska, Joanna Reczkowicz, Tomasz Pałka, Przemysław Bujas, Anna Piotrowska

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Multiple myeloma; Nordic Walking; intermittent fasting; sclerostin; Dickkopf-related protein 1; osteoprotegrin; Tartrate-resistant acid phosphatase 5b; Wnt pathway; vitamin D; cancer rehabilitation; elderly

Online: 3 April 2024 (14:27:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0295.v1

Vitamin D: A Bridge between Kidney and Heart

Carmine Secondulfo, Valeria Visco, Nicola Virtuoso, Martino Fortunato, Serena Migliarino, Antonella Rispoli, Lucia La Mura, Adolfo Stellato, Giuseppe Caliendo, Emanuela Settembre, Fabiana Galluccio, Sarah Hamzeh, Giancarlo Bilancio

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: vitamin D; calcitriol; calcidiol; kidney disease; cardiovascular disease; hypertension; osteoporosis; mineral-bone disease; metabolic disease.

Online: 3 April 2024 (12:57:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0299.v1

Regular Internet Users across the Italian Regions

Angelo Leogrande

Subject: Business, Economics And Management, Economics Keywords: Innovation; Innovation and Invention; Management of Technological Innovation and R&; D; Technological Change; Intellectual Property and Intellectual Capital

Online: 3 April 2024 (12:43:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0222.v1

Cultural and Creative Employment across Italian Regions

Angelo Leogrande

Subject: Business, Economics And Management, Economics Keywords: Innovation, Innovation and Invention, Management of Technological Innovation and R&; D, Technological Change, Intellectual Property and Intellectual Capital

Online: 2 April 2024 (16:06:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1860.v1

Individualized Supplementation of Immunoactive Micronutrients and Severity of Upper Respiratory Infection Symptoms – a Randomized Intervention Study

Melanie Haas, Beate Brandl, Laura Schinhammer, Thomas Skurk

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dried blood spots (DBS); upper respiratory tract infections (URI); personalized nutrition; vitamin D; selenium; zinc; WURS

Online: 29 March 2024 (15:53:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1670.v1

PatchFusion: Patch-based Nonrigid Tracking and Reconstruction of Deformable Objects using a Single RGB-D Sensor

Mingyuan Zhao, Xuexin Yu, Long Xu

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: nonrigid tracking; deformable objects; RGB-D sensor; deformation optimization

Online: 27 March 2024 (14:11:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1580.v1

Knowledge Workers in the Italian Regions

Angelo Leogrande

Subject: Business, Economics And Management, Economics Keywords: Innovation; Innovation and Invention; Management of Technological Innovation and R&; D; Technological Change; Intellectual Property and Intellectual Capital

Online: 26 March 2024 (11:24:22 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202403.1565.v1

Are Gamers Prone to eThrombosis during Long Gaming Sessions?

Kasper Bygum Krarup, Henrik Bygum Krarup, Morten Moerk, Søren Lundbye-Christensen, Aase Handberg, Hien Thi Thu Nguyen, Inge Søkilde Pedersen, Søren Risom Kristensen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: eThrombosis; LAN party; thrombin generation; coagulation activation; TAT; F1+2; D-dimer

Online: 26 March 2024 (08:11:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0320.v1

National Agricultural Innovation System (NAIS): Diagnosis, Gaps and Mapping of Actors

Luis Fernando Gutiérrez Cano, Jhon Wilder Zartha Sossa, John Fredy Moreno Sarta, Juan Camilo Oviedo Lopera, Jorge Iván Quintero Saavedra, Lina María Suárez Guzmán, Diego Alejandro Agudelo Tapasco, Orlando Rodríguez García

Subject: Business, Economics And Management, Business And Management Keywords: Systems of Innovation,; National Agricultural Innovation System; gaps; Innovation and Development (R&D); training; , ICT; sustainability

Online: 6 March 2024 (04:29:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0217.v1

Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small Molecule Positive Allosteric Modulator SPAM1 of PAC1-R for the Treatment of D-gal-Induced Aging Mice

Lili Liang, Shang Chen, Wanlin Su, Huahua Zhang, Rongjie Yu

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: pituitary adenylate cyclase- activating polypeptide (PACAP); Pituitary adenylate cyclase-activating polypeptide receptor 1 (PAC1-R); D-galactose (D-gal); neuroprotective effects; transcriptomic; proteomic

Online: 5 March 2024 (12:50:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0222.v1

Effects of Zilpaterol Hydrochloride with a Combination of Vitamin D3 on Feedlot Lambs: Growth Performance, Dietary Energetics, Carcass Traits, and Meat Quality.

Karla H. Leyva-Medina, Horacio Dávila-Ramos, Jesús J. Portillo-Loera, Omar S. Acuña-Meléndez, Adriana Cervantes-Noriega, Jaime N. Sánchez-Pérez, Gamaliel Molina-Gámez, Javier G. Rodríguez-Carpena, Mario A. Mejía-Delgadillo, Juan C. Robles-Estrada

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: β -agonist; vitamin D; ruminant; growth performance; carcass traits; meat quality

Online: 5 March 2024 (06:46:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1488.v1

Residential Greenness, Lifestyle and Vitamin D: A Longitudinal Cohort of South Asian Origin and Caucasian Ethnicity Women Living in the South of the UK

Keila Valente de Souza Santana, Helena Ribeiro, Andrea Darling, Israel Henrique Ribeiro Rios, Susan Lanham-New

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Vitamin D, Ultraviolet radiation, Residential greenness, Ethnicity, Parathyroid hormone.

Online: 26 February 2024 (15:50:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1448.v1

Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea

Kostas Archontogeorgis, Nicholas-Tiberio Economou, Panagiotis Bargiotas, Evangelia Nena, Athanasios Voulgaris, Konstantina Chadia, Georgia Trakada, Andrea Romigi, Paschalis Steiropoulos

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Vitamin D; sleepiness; obstructive sleep apnea (OSA); sleep apnea; Epworth Sleepiness Scale (ESS)

Online: 26 February 2024 (13:57:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1344.v1

Autoimmune Thyroiditis and Vitamin D

Teodoro Durá-Travé, Fidel Gallinas Victoriano

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Anti-thyroglobulin antibodies; Anti-thyroid peroxidase; Autoimmunity; Autoimmune thyroiditis; Hashimoto thyroiditis; Immune cells; Vitamin D; Vitamin D deficiency; Vitamin D supplementation

Online: 23 February 2024 (10:08:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0963.v1

Current and Emerging Treatment Options in Pediatric Onset Multiple Sclerosis

Artemis Mavridi, Maria Eleni Bompou, Aine Margaret Redmond, Paraschos Archontakis-Barakakis, George D. Vavougios, DIMOS-DIMITRIOS MITSIKOSTAS, Theodoros Mavridis

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: POMS; Pediatric Onset Multiple Sclerosis; Disease-modifying therapies; DMT; Pediatric MS; Interferons; Finglolimod; Teriflunomide; Cyclophosphamide; Rituximab; Ocrelizumab; Daclizumab; Alemtuzumab; Natalizumab; Ofatumumab; Siponimod; Vitamin D; TCR vaccine; Stem cell therapy; Glatiramer acetate; Azathioprine; Dimethyl fumarate; Mitoxantrone

Online: 19 February 2024 (14:52:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0784.v1

A Review of 3-D Printing Batteries

Maryam Mottaghi, Joshua M. Pearce

Subject: Engineering, Energy And Fuel Technology Keywords: 3-D printing; Additive Manufacturing; Batteries; Electricity; Energy; Energy storage; Open source; Open source hardware

Online: 14 February 2024 (09:44:29 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0669.v1

Renormalization and Thermodynamics of Probe-D-Branes: Wilsonian RG Analysis and Infrared Regime Studies

Matthew James Stephenson

Subject: Physical Sciences, Mathematical Physics Keywords: Probe-D-Branes; Wilsonian Renormalization Group; Dirac-Born-Infeld Action; Holographic Renormalization; Infrared Regime; Thermodynamics; Grand Potential; RG Equation; String Theory; Higher-Dimensional Spacetime; Counter-Terms; Convergence; Renormalization Constants; Temperature Effects; Supergravity; AdS/CFT Correspondence; Mirror Symmetry

Online: 13 February 2024 (05:58:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0709.v1

A 2.4 GHz Wide-Range CMOS Current-Mode Class-D PA with HD2 Suppression for Internet of Things Applications

Nam-Seog Kim

Subject: Engineering, Electrical And Electronic Engineering Keywords: Bluetooth low energy (BLE); Class-D power amplifier (PA); complementary metal–oxide–semiconductor (CMOS); current-mode; second harmonic distortion (HD2); internet of things (IoT); transmitter (TX); power efficiency; wireless sensor network (WSN); Zigbee

Online: 12 February 2024 (15:52:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0679.v1

Targeting N‐methyl‐D‐aspartate Receptors in Neurodegenerative Diseases

Allison Carles, Aline Freyssin, Florent Perin-Dureau, Gilles Rubinstenn, Tangui Maurice

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: N-methyl-D-aspartate receptor; Alzheimer's disease; post-traumatic stress disorder; Fluoroethylnormemantine (FENM)

Online: 12 February 2024 (13:20:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0378.v1

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Carmelinda Ruggiero, Laura Tafaro, Luisella Cianferotti, Flavia Tramontana, Ilaria Giovanna Macchione, Carla Caffarelli, Agostino Virdis, Marika Ferracci, Giuseppe Rinonapoli, Patrizia Mecocci, Nicola Napoli, Valeria Calsolaro

Subject: Medicine And Pharmacology, Other Keywords: aging; hallmarks of aging; vitamin D; clinical studies

Online: 6 February 2024 (15:25:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0370.v1

The Effect of R&D Investment of Chinese Companies on Business Innovation Performance

EnLu Jiang, ZhengGuang Li

Subject: Business, Economics And Management, Accounting And Taxation Keywords: R&D Investment; Industry Diversification; Technology Diversification; Business Innovation.

Online: 6 February 2024 (13:07:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0325.v1

Dynamics of Converging Scientific and Technological Development in Artificial Intelligence and Quantum Technologies

Mario Coccia

Subject: Social Sciences, Other Keywords: Quantum Technologies; Artificial Intelligence; Technological trajectories; R&; D Management; Converging technologies; Technological interaction; Technological evolution; Technometrics; Technological Advances

Online: 6 February 2024 (05:16:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0032.v1

Strategy Development Based on the Hydrogen Businesses in Côte d’Ivoire

Kassé Jean Hugues Angbé, Yawovi Nougbléga, Satyanarayana Narra, Vidhi Singh

Subject: Engineering, Energy And Fuel Technology Keywords: Cô; te d’ Ivoire; strategy; business; hydrogen; crop residues

Online: 1 February 2024 (12:52:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1991.v1

Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-loop Formation Than for Oligonucleotide Strand Exchange

Masayuki Takahashi, Axelle Renodon-Corniere, Tsutomu Mikawa, Naoyuki Kuwabara, Kentaro Ito, Dmitri Levitsky, Hiroshi Iwasaki

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Rad51 protein; homologous recombination; DNA strand exchange; Calcium ion; D-loop formation

Online: 30 January 2024 (03:41:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2038.v1

Fractal Dimension of the Generalized Z-Entropy of The Rényian Formalism of Stable Queue with Some Potential Applications of Fractal Dimension to Big Data Analytics

Dr Ismail A Mageed

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: Fractal Dimension(D), Generalized Z-Entropy, Google Earth satellite (GEs),GNU Image Manipulation, Big Data Analytics(BDAs).

Online: 29 January 2024 (14:39:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2001.v1

Fractal Dimension(D_f )Theory of Ismail's entropy(IE) with Potential D_f applications to Smart Cities

Dr Ismail A Mageed

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: Fractal dimension((D_f ); Ismail entropy (IE); Information theory; smart cities

Online: 29 January 2024 (08:32:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1787.v1

Vitamin D deficiency, Chronic kidney disease and Periodontitis

Imaan Ganimusa, Emily Chew, Emily Ming-Chieh Lu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Vitamin D, Chronic kidney disease, periodontitis

Online: 24 January 2024 (16:53:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1759.v1

A Review on Benzophenone-Based Derivatives for Organic Light Emitting Diodes

Dovydas Blazevicius, Saulius Grigalevicius

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Donor-acceptor-donor (D-A-D) derivatives; organic light emitting diode (OLED); high efficiency; emission; thermal analysis; synthesis.

Online: 24 January 2024 (10:38:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1049.v1

Gradual Emergence of East African Cassava Mosaic Cameroon Virus in Cassava Farms in Côte d’Ivoire

Békanvié Serge Marie KOUAKOU, Aya Ange Naté Yoboué, Justin S. PITA, J. Musembi Mutuku, Daniel H. Otron, Nazaire K. Kouassi, Kan Modeste Kouassi, Linda Patricia L. Vanié-Léabo, Cyrielle Ndougonna, Michel Zouzou, Fatogoma Sorho

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Epidemiology; CMD; begomoviruses; Cô; te d’ Ivoire

Online: 15 January 2024 (10:27:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1070.v1

Exact Closed-Form M/D/c Queueing Delay Formula

David Tung Chong Wong

Subject: Computer Science And Mathematics, Mathematics Keywords: M/D/c Queue; Poisson Arrivals; Deterministic (Constant) Service Time; c Multiple Servers; root(s) of an equation; mean number of customers; mean queueing delay

Online: 15 January 2024 (08:50:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1881.v2

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Patrick W. Chambers, Shae E. Chambers

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: IFN-γ ; γ δ T cells; microbiome; d-mannose; TNF-α

Online: 28 December 2023 (14:34:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1993.v1

Roles of Glutathione and AP-1 in the Enhancement of Vitamin D-induced Differentiation by Activators of the Nrf2 Signaling Pathway in Acute Myeloid Leukemia Cells

Yasmeen Jramne-Saleem, Michael Danilenko

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: acute myeloid leukemia; buthionine sulfoximine; carnosic acid; monomethyl fumarate; vitamin D receptor; activator protein-1.

Online: 26 December 2023 (12:15:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1227.v1

Optimal Planning of PV Sources and D-STATCOM Devices with Network Reconfiguration Employing Modified Ant Lion Optimizer

SUJATHA B C, Usha A, Geetha R S

Subject: Engineering, Electrical And Electronic Engineering Keywords: distributed generators (DG); Distributed Static Compensators (D-STATCOM); network reconfiguration; load models; MALO algorithm; BAT algorithm

Online: 18 December 2023 (06:24:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1240.v1

On R-fuzzy Soft δ-Open Sets and Applications via Fuzzy Soft Topologies

Ibtesam Alshammari, Mesfer H. Alqahtani, Islam M. Taha

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: fuzzy soft set; fuzzy soft topological space; r-fuzzy soft d-open set; fuzzy soft d-continuity; fuzzy soft almost (weakly) continuity and fuzzy soft (L,M,N,O)-continuity

Online: 18 December 2023 (06:01:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1112.v1

Nutritional Strategies to Mitigate Post-Weaning Challenges in Pigs: A Focus on Glucans, Vitamin D, and Selenium

John V O'Doherty, Alison Dowley, Eadaoin Conway, Torres Sweeney

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: pig; weaning; β-glucans; mushrooms, vitamin D, selenium, dam

Online: 14 December 2023 (17:12:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0961.v1

Cardiac Device Therapy in Patients with Chronic Kidney Disease – an Update

Bogdan Caba, Laura Vasiliu, Alexandra Maria Covic, Radu Andy Sascau, Cristian Stătescu, Adrian C. Covic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: CKD; HF; CRT; LVAD; ICD; CIED; CRT-D; complications; mortality

Online: 13 December 2023 (10:19:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0891.v1

A 3-D Viscous Vorticity Model for Predicting Turbulent Flows over Hydrofoils

Rui You, Spyros A Kinnas

Subject: Engineering, Marine Engineering Keywords: Software Development; Viscous Vorticity Equation; Turbulence Modeling; 3-D Hydrofoil; Computational Fluid Dynamics

Online: 12 December 2023 (12:47:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0492.v1

The Smart Cane Based on 2D LiDAR and RGB-D Camera Sensor Realizing Navigation and Obstacle Recognition

Chunming Mai, Huaze Chen, Lina Zeng, Zaijin Li, Guojun Liu, Zhongliang Qiao, Yi Qu, Lianhe Li, Lin Li

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Smart Cane; Jetson Nano (B01); 2D LiDAR; RGB-D Camera; Laser SLAM; Target Recognition; Cartographer; Improved Yolov5

Online: 7 December 2023 (07:52:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1479.v1

Experimental Thermal Conductivity Measurement of Hollow Structure Polypropylene Material By DTC-25 and Hot Box Test

Osasu Osaze, Sanjeev Khanna

Subject: Engineering, Energy And Fuel Technology Keywords: Thermal conductivity; polypropylene; hollow structure; DTC-25; Hot Box; Rayleigh number; heat flux sensor

Online: 23 November 2023 (05:01:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1315.v1

Methylation of the Vitamin D Receptor (VDR) gene in human disorders

Beatrice Gasperini, Angela Falvino, Eleonora Piccirilli, Umberto Tarantino, Annalisa Botta, Virginia Veronica Visconti

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Vitamin D receptor (VDR); Epigenetics; DNA methylation; VDR-related diseases

Online: 21 November 2023 (10:47:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1099.v1

Characterization of Sr1-xYxCoO3- (X= 0.1, 0.2) Perovskites as Plausible Cathode Materials in Solid Oxide Fuel Cells

Yan Li, Loreto Troncoso, Maria Teresa Fernández, José Antonio Alonso

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: cathode material; SOFC; SrCoO3-d perovskite; neutron diffraction

Online: 17 November 2023 (08:57:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1076.v1

The Candida Covid Connection: Preexisting Candida Overgrowth and Gut Dysbiosis Drives Long Covid

Patrick Chambers

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: D-mannose; butyrate; acetaldehyde; serotonin; autoimmunity

Online: 17 November 2023 (04:28:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1067.v1

The Association of Vitamin D with Non-melanoma Skin Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses

Konstantinos Seretis, Nikolaos Bounas, Chrissa Sioka

Subject: Medicine And Pharmacology, Dermatology Keywords: Non-melanoma skin cancer; Vitamin D; risk; Vitamin D receptor; review; VDR polymorphism

Online: 16 November 2023 (10:46:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0897.v1

The Role of Sleep in Multiple Sclerosis

Susanna Cordone, Valentina Alfonsi, Luigi De Gennaro

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: multiple sclerosis; sleep; immune system; neuroinflammation; cytokines; mitochondria; neuro-degeneration; melatonin; vitamin D; sleep-based interventions.

Online: 14 November 2023 (09:44:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0596.v1

Bicarbazole-Benzophenone Based Twisted D-A-D Derivatives as Blue Emitters for Highly Efficient Fluorescent OLEDs

Dovydas Blazevicius, Iram Siddiqui, Prakalp Gautam, Gintare Krucaite, Daiva Tavgeniene, Mangey Ram Nagar, Krishan Kumar, Subrata Banik, Jwo-Huei Jou, Saulius Grigalevicius

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Donor-acceptor-donor (D-A-D) derivatives; blue organic light emitting diode (OLED); high efficiency; blue emission; thermal analysis

Online: 9 November 2023 (07:48:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0477.v1

Clinical Impact of Digitalis Therapy in a Large Multicenter Cohort of CRT‐Recipients

Julia W Erath, Nikolett Vigh, Balázs Muk, Carsten W Israel, Badder Kattih, Dávid Pilecky, Gabor Z Duray, Mate Vamos

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: digitalis; digoxin; digitoxin; cardiac‐resynchronization‐therapy; CRT‐D; defibrillator; congestive heart failure; mortality; CRT response

Online: 7 November 2023 (14:18:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0402.v1

Calcitriol Downregulates ACE1/ACE2, Renin and TMPRSS2 Gene Expression in the Human Placenta

Rafael Vargas-Castro, Andrea Olmos-Ortiz, Janice García-Quiroz, Euclides Avila, Fernando Larrea, Lorenza Díaz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Syncytiotrophoblasts; Renin-Angiotensin-Aldosterone; ACE1; ACE2; TMPRSS2; Calcitriol; Vitamin D; Blood pressure; Pregnancy

Online: 7 November 2023 (11:36:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0340.v1

The Efficacy and Safety of High Dose Cholecalciferol Therapy in Hemodialysis Patients

Agnieszka Tarasewicz, Michał Komorniczak, Agnieszka Zakrzewska, Bogdan Biedunkiewicz, Sylwia Małgorzewicz, Magdalena Jankowska, Katarzyna Jasiulewicz, Natalia Płonka, Małgorzata Dąbrowska, Alicja Dębska-Ślizień, Leszek Tylicki

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: vitamin D; cholecalciferol; 25-hydroxycholecalciferol, calcidiol; calcitriol; hemodialysis; parathyroid hormone; chronic kidney disease; chronic kidney disease–mineral; bone disorder

Online: 7 November 2023 (02:38:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0330.v1

Association between lifestyle factors and COVID-19: findings from Qatar Biobank

Zoha Akbar, Hasna H. Kunhipurayil, Jessica Saliba, Jamil Ahmad, Layla Al-Mansoori, Hebah A Al-Khatib, Asmaa A. Al Thani, Zumin Shi, Abdullah A. Shaito

Subject: Public Health And Healthcare, Primary Health Care Keywords: COVID-19; Smoking; Vitamin D; Obesity; Bariatric Surgery; Dietary Patterns

Online: 7 November 2023 (02:18:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1742.v1

Comparison of an Individualized vs. Standardized Vitamin D Supplementation for Insufficient 25(OH)D Status Correction in Athletes—A Randomized Controlled Intervention Study

Chiara Tuma, Arne Schick, Nele Pommerening, Hans Braun, Mario Thevis

Subject: Biology And Life Sciences, Life Sciences Keywords: vitamin D; sports nutrition; personalized nutrition; microsampling; VAMS; HPLC-MS/MS

Online: 27 October 2023 (07:14:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1664.v1

Experimental Measurement of Thermal Conductivity of Fused Deposition Modelling Materials with Conductivity Meter DTC-25

Antonio Rodriguez, Juan Pablo Fuertes, Añaterve Oval, Gurutze Pérez-Artieda

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Additive manufacturing; fused deposition modeling; filament; thermal conductivity; 3D printing; DTC-25

Online: 25 October 2023 (16:10:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1308.v1

Association of Urinary Arsenic with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China

Kunyu Zhang, Yunyi Yin, Man Lv, Xin Zhang, Meichen Zhang, Jia Cui, Ziqiao Guan, Xiaona Liu, Yang Liu, Yanhui Gao, Yanmei Yang

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: arsenic; serum 25(OH)D; methylation capacity; skin hyperkeratosis

Online: 20 October 2023 (08:34:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0958.v1

Effect of Parasitic Channel on DC/AC/RF Characteristics and Power Consumption of GAA Si NS MOSFETs and Circuits

Sekhar Reddy Kola, Yiming Li

Subject: Engineering, Electrical And Electronic Engineering Keywords: gate-all-around; nanosheet; silicon-on-insulator; vertically stacked; parasitic channel; short-channel effect; current densities; gate capacitances; transconductance; cut-off frequency; 3dB frequency; power consumption; 3-D device simulation

Online: 16 October 2023 (09:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0318.v2

Altered Expression of Vitamin D Metabolism Genes and Circulating MicroRNAs in PBMCs of Patients with Type 1 Diabetes: Their Association with Vitamin D Status and Ongoing Islet Autoimmunity

Hakeemah Al-nakhle, Ihsan Mohsen, Bashir Elnaem, Abdullah Alharbi, Ibtisam Alnakhli, Shareefa Almoarfi, Jameela Fallatah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Type 1 diabetes mellitus; 1,25-Dihydroxy Vitamin D; PBMCs; 1α-hydroxylase (CYP27B1); 24-hydroxylase (CYP24A1); miRNA; Ongoing Islet Autoimmunity

Online: 9 October 2023 (09:28:37 CEST)

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Background: The immunomodulatory role of 1,25-Dihydroxy vitamin D3 (1,25(OH)2D3) is exerted through its interaction with the Vitamin D receptor (VDR) present on pancreatic and immune cells. While a deficiency in Vitamin D has been linked to Type 1 Diabetes Mellitus (T1DM), the exact molecular mechanism driving this down-regulation in T1DM is yet to be fully understood. This study aimed to decipher differences in the expression of genes associated with Vitamin D metabolism in T1DM patients and to ascertain if there is a correlation between serum 1,25(OH)2D3 levels and the expression of these genes. We also sought to understand the influence of specific microRNAs (miRNAs) on the expression of Vitamin D metabolism genes in peripheral blood mononuclear cells (PBMCs) of T1DM patients. Furthermore, the study delved into the potential implications of altered Vitamin D metabolism genes and miRNAs on autoimmune processes. Methods: Utilizing real-time PCR, we assessed the expression profiles of genes encoding for 1-hydroxylases (CYP27B1) and 24-hydroxylases (CYP24A1), as well as related miRNAs, in PBMCs from 30 T1DM patients and 23 healthy controls. ELISA tests facilitated the measurement of 1,25(OH)2D3, GAD65, and IA-2 levels. Results: Our findings showcased down-regulated CYP27B1 mRNA levels, while CYP24A1 expression remained stable compared to healthy subjects (CYP27B1, p = 0.0005; CYP24A1, p = 0.205, respectively). In T1DM patients, the levels of has-miR-216b-5p were found to be increased, while the levels of has-miR-21-5p were decreased in comparison to the control group. Notably, no correlation was identified between the expression of CYP27B1 in T1DM patients and the levels of has-miR-216b-5p, has-miR-21-5p, and 1,25(OH)2D3. A significant negative correlation was identified between CYP27B1 mRNA levels in PBMCs of T1DM and IA2, but not with GAD65. Conclusions: The study highlights there were reduced levels of both CYP27B1 mRNA and has-miR-21-5p, along with elevated levels of has-miR-216b-5p in the PBMCs of T1DM. However, the absence of a correlation between the expression of CYP27B1, levels of has-miR-216b-5p, and the status of 1,25(OH)2D3 suggests the possible existence of other regulatory mechanisms. Additionally, the inverse relationship between IA2 autoantibodies and CYP27B1 expression in T1DM patients indicates a potential connection between this gene and the autoimmune processes inherent in T1DM.

Preprint ARTICLE | doi:10.20944/preprints202310.0304.v1

Effects of Revenue-Sharing Contracts and Overconfidence on Innovation for Key Components

Chengli Wei, Hongzhuan Chen, Yuanfei Kang

Subject: Business, Economics And Management, Business And Management Keywords: key components; overconfidence; revenue-sharing; R&D investment

Online: 6 October 2023 (07:54:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0184.v1

The Proinflammatory Effects of 25-Hydroxyvitamin D3 in New-Onset Type 2 Diabetes Mellitus and Prediabetes

Aysen Kutan Fenercioglu, Mustafa Sait Gonen, Hafize Uzun, Nurver Turfaner Sipahioglu, Gunay Can, Ebru Tas, Zehra Kara, Hande Mefkure Ozkaya, Pinar Atukeren

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Prediabetes, type 2 diabetes mellitus, 25-hydroxyvitamin D3, inflammation, interleukins, TNF-α, NF-kB, MAPK

Online: 4 October 2023 (13:09:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0029.v1

Vitamin D status in Bipolar Disorder

Zita Späth, Adelina Tmava-Berisha, Frederike T. Fellendorf, Tatjana Stross, Alexander Maget, Martina Platzer, Susanne A. Bengesser, Alfred Häussl, Ina Zwigl, Armin Birner, Robert Queissner, Katharina Stix, Linda Wels, Melanie Lenger, Nina Dalkner, Sieglinde Zelzer, Markus Herrmann, Eva Z. Reininghaus

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: bipolar disorder; vitamin D metabolism; functional vitamin D deficiency; 25(OH)D; 24,25(OH)2D; VMR

Online: 2 October 2023 (03:58:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1606.v1

Vitamin D3 Exerts Beneficial Effects on Aging Muscles through Activation of the Vitamin D Receptor (VDR)/Sirtuin (SIRT)1/3 Axis

Nurul Fatihah Talib, Zunshu Zhu, Kyoung Soo Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Vitamin D; Vitamin D receptor (VDR); Sirtuin; Sarcopenia; Muscle atrophy; Mitochondrial Biogenesis; Oxidative Phosphorylation (OXPHOS)

Online: 25 September 2023 (12:55:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1427.v1

Comparison of the 10-, 14- and 20-Item CES-D Scores as Predictors of Cognitive Decline

Ainara Jauregi Zinkunegi, Rebecca Langhough, Sterling Johnson, Kimberly Mueller, Davide Bruno

Subject: Social Sciences, Psychology Keywords: depression; CES-D; cognitive decline; MCI; aging

Online: 21 September 2023 (03:54:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1235.v1

Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor of Bronchopulmonary Dysplasia or Death?

Sophie Laborie, Maxime Bonjour, Justine Bacchetta, Mathilde Mauras, Marine Butin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: vitamin D; premature infants; bronchopulmonary dysplasia; low birth weight infant; very low birth weight infant

Online: 19 September 2023 (05:28:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1242.v1

D-serine Is a Gliotransmitter or Neurotransmitter

ELHACHMI ER-RACHDAOUI

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: D-Serine; gliotransmitter; neurotransmitter; NMDAR; plasticity

Online: 19 September 2023 (04:48:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1195.v1

Nearly Linear-Phase 2-D Recursive Digital Filters Design using Balanced Realization Model Reduction

Abdussalam Omar, Dale Shpak, Panajotis Agathoklis

Subject: Engineering, Electrical And Electronic Engineering Keywords: 2-D IIR digital filters; Structured Gramians; Lyapunov inequalities; Linear matrix inequalities(LMI); Balanced truncation

Online: 19 September 2023 (03:07:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1019.v1

Vitamin D Levels as a Marker of Severe SARS-Cov-2 Infection

Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Sofia Nikolakopoulou, Alexandra Konstantinou, Olga Mascha, Evangelos Siarkos, Charilaos Samaras, Panagiotis Athanassiou, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: vitamin D; SARS-CoV-2; outcome; ferritin; d-dimers; fibrinogen

Online: 15 September 2023 (02:40:24 CEST)

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Severe infection from the SARS-CoV-2 virus is associated with various clinical findings, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may lead to death. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is concerned. The aim was to measure 25(OH)D3 levels in patients hospitalized for severe COVID-19 infection, to explore the relationship between 25(OH)D3 and outcome and to investigate the relationship between 25(OH)D3 levels, CRP, ferritin, d-dimers and fibrinogen levels in this cohort. In a cohort of 88 patients hospitalized for severe infection from the SARS-CoV-2 virus and a control group matched for age and sex the levels of 25(OH)D3 were measured. In the same cohort CRP, ferritin, d-dimer and fibrinogen levels were also analyzed. Levels of 25(OH)D3 were 17.36±8.80 ng/ml (mean±SD) as compared with 24.34±10.34 ng/ml, in patients with severe SARS-CoV-2 infection and the control group, respectively, p<0.001 (Student’s t test). The levels of 25(OH)D3 were found to be significantly related to outcome, i.e. survival as opposed to non-survival, as more patients with 25(OH)D3 deficiency (0-10 ng/ml) and insufficiency (10-20 ng/ml) had a fatal outcome as compared with those with vitamin D sufficiency, p<0.001, chi-square test, p<0.001, Fischer’s exact test. Levels of 25(OH)D3 were inversely related to CRP, ferritin, d-dimer and fibrinogen levels, p<0.001, linear regression analysis, beta coefficient of variation, -0.176, -0,160, -0.178, -0.158, respectively. Vitamin D deficiency observed in severe SARS-CoV-2 infection was related to the disease outcome. Increased ferritin levels, and increased thrombotic markers, namely d-dimer and fibrinogen levels were observed in the patients and their concentration was also inversely related to vitamin D. We showed that vitamin D levels were low in hospitalized patients with severe SARS-CoV-2 infection and also inversely related to CRP, ferritin, d-dimer and fibrinogen concentration. It is proposed that vitamin D levels may be an index of severity in the context of SARS-CoV-2 infection.

Preprint ARTICLE | doi:10.20944/preprints202303.0418.v3

Long COVID, POTS, CFS and MTHFR: Linked by Biochemistry and Nutrition

Patrick Chambers

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: homocysteine; MTHFR; circumventricular organ; magnesium; vitamin D; CD147

Online: 15 September 2023 (02:37:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0842.v1

Factors Associated with Humoral Immune Response Following the Third Dose of the BNT162b2 Received by Employees at a Health–Care Facility

Patrik Palacka, Alena Svobodová, Lucia Skokanová, Jana Obertová, Katarína Rejleková, Róbert Babeľa, Michal Mego, Martina Vulganová, Juraj Pechan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: BNT162b2; efficacy; safety; neutralizing IgG antibodies; 25–hydroxyl vitamin D

Online: 13 September 2023 (05:33:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0595.v1

The Role Of Vitamin D And Its Molecular Bases In Insulin-Resistance Diabetes, Metabolic Syndrome And Cardiovascular Disease: State Of Art

Christiano Argano, Luigi Mirarchi, Simona Amodeo, Valentina Orlando, Alessandra Torres, Salvatore Corrao

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: vitamin D; insulin-resistance; metabolic syndrome; type 1 and 2 diabetes; gestational diabetes; cardiovascular diseases and metabolism

Online: 8 September 2023 (15:34:53 CEST)

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In the last decade, an increasing awareness was directed to the role of Vitamin D in non-skeletal and preventive roles for chronic diseases. Vitamin D is a key hormone involved in the regulation of calcium/phosphorous balance and it has been implicated in the pathogenesis of inflammation, insulin resistance and obesity. Cholecalciferol (Vitamin D3) and Ergocalciferol (Vitamin D2) are the main form of vitamin D: the active form (1,25-dihydroxyvitamin D) is the result of two hydroxylations that take place in liver, kidney, pancreas and immune cells. Some anti-inflammatory cytokines are produced at higher levels by vitamin D, while some pro-inflammatory cytokines are released at lower levels. Toll-Like Receptor (TLR) expression is increased and a pro-inflammatory state is also linked to low levels of vitamin D. Regardless of how it affects inflammation, various pathways suggest that vitamin D directly improves insulin sensitivity and secretion. The level of vitamin D in the body may change the ratio of pro- to anti-inflammatory cytokines, which would impact insulin action, lipid metabolism, and the development and function of adipose tissue. Many studies have demonstrated an inverse relationship between vitamin D concentrations and pro-inflammatory markers, insulin resistance, glucose intolerance, metabolic syndrome, obesity and cardiovascular disease. It's interesting to note that several long-term studies also revealed an inverse correlation between vitamin D level and the occurrence of diabetes mellitus. Vitamin D supplementation in people has controversial effects, in fact while some studies demonstrated improvements in insulin sensitivity, glucose and lipid metabolism, others revealed no significant effect on glycemic control and inflammation. The aim of this review is to provide insight into the molecular basis of the relationship between vitamin D, insulin-resistance, metabolic syndrome, type 1 and 2 diabetes, gestational diabetes, and cardiovascular diseases.

Preprint ARTICLE | doi:10.20944/preprints202309.0292.v1

Interaction of Vitamin D Receptor Polymorphism With Inflammation and Calcification Markers, Effect on All-Cause Mortality in Women on Dialysis

Marcela Avila, María-del Carmen Prado-Uribe, Carmen Mora, Alfonso Cueto-Manzano, Abdul Rashid Qureshi, Bengt Lindholm, Sofia Bernal-Amador, Ramón Paniagua

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: bone mineral markers; phosphate/calcium homeostasis; dialysis; inflammation; mortality; vitamin D receptor polymorphism; diabetes; vascular calcification; hs-CRP; CKD

Online: 6 September 2023 (03:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0007.v1

Talarolide A and Talaropeptides A-D: Potential Marine-Derived Therapeutic Peptides with Interesting Chemistry and Biological Activity Studied through Density Functional Theory (DFT) and Conceptual DFT

Norma Flores-Holguín, Joan Sebastian Salas-Leiva, Daniel Glossman-Mitnik

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: Talaloride A; Talaropeptides A-D; DFT; Conceptual DFT; KID; Cheminformatics; Pharmacokinetics

Online: 1 September 2023 (12:00:13 CEST)

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Molecules sourced from marine environments hold immense promise for the development of novel therapeutic drugs, owing to their distinctive chemical compositions and valuable medicinal attributes. Notably, Talarolide A and Talaropeptides A-D have gained recent attention as potential candidates for pharmaceutical applications. This study aims to explore the chemical reactivity of Talarolide A and Talaropeptides A-D through the application of molecular modeling and computational chemistry techniques, specifically employing Conceptual Density Functional Theory (CDFT). By investigating their chemical behaviors, the study seeks to contribute to the understanding of the potential pharmacological uses of these marine-derived compounds. The investigation involves the utilization of molecular modeling and computational chemistry tools, with a specific focus on Conceptual DFT. These techniques are applied to examine the chemical reactivity of Talarolide A and Talaropeptides A-D, shedding light on their potential for interacting with various biological targets. The research reveals insights into the chemical reactivity of Talarolide A and Talaropeptides A-D, uncovering active reaction sites and potential biological targets. Talarolide A demonstrates robust anti-inflammatory properties and antitumor activity against diverse cancer cell lines, while Talaropeptide A displays antimicrobial efficacy against both bacteria and fungi. The study underscores the significance of comprehending the chemical reactivity of natural marine products for advancing pharmaceutical development. By employing computational tools such as Conceptual DFT, this research uncovers crucial information about the active sites and potential targets of Talarolide A and Talaropeptides A-D. The findings contribute to the broader understanding of marine-derived peptides and their prospects as pharmaceutical agents, though further investigations are necessary to fully elucidate their pharmacological attributes.

Preprint ARTICLE | doi:10.20944/preprints202308.1352.v1

Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial

Naohisa Tomosugi, Yoshitaka Koshino, Chie Ogawa, Kunimi Maeda, Noriaki Shimada, Kimio Tomita, Shoichiro Daimon, Tsutomu Shikano, Kazuyuki Ryu, Toru Takatani, Kazuya Sakamoto, Satonori Ueyama, Daisuke Nagasaku, Masato Nakamura, Shibun Ra, Masataka Nishimura, Chieko Takagi, Yoji Ishii, Noritoshi Kudo, Shinsuke Takechi, Takashi Ishizu, Takamoto Yanagawa, Masamichi Fukuda, Yutaka Nitta, Takayuki Yamaoka, Taku Saito, Suzuko Imayoshi, Momoyo Omata, Joji Oshima, Akira Onozaki, Hiroaki Ichihashi, Yasuhisa Matsushima, Hisahito Takae, Ryoichi Nakazawa, Koichi Ikeda, Masato Tsuboi, Keiko Konishi, Shouzaburo Kato, Maki Ooura, Masaki Koyama, Tsukasa Naganuma, Makoto Ogi, Shigeyuki Katayama, Toshiaki Okumura, Shigemi Kameda, Sayuri Shirai

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: oral iron absorption; ferric citrate hydrate; hemodialysis; hepcidin-25; iron shift

Online: 18 August 2023 (11:20:29 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202308.1253.v1

Retinal Microvascular Alterations in a Patient with Type 1 Diabetes, Hemoglobin D Hemoglobinopathy and High Myopia – Case Report and Review of Literature

Alexandra Oltea Dan, Andrei Teodor Bălășoiu, Ileana Puiu, Andreea Cornelia Tanasie, Anca Elena Târtea, Veronica Sfredel

Subject: Medicine And Pharmacology, Ophthalmology Keywords: OCT angiography, diabetes type 1, hemoglobin D, high myopia

Online: 17 August 2023 (05:31:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1071.v1

Microglial-targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn DJ Huizar, Silvia Picciolini, Ajit G. Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M. Kannan, Marzia Bedoni, Rana Rais, Barbara S. Slusher

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; DPTIP; hydroxyl PAMAM dendrimer; D-DPTIP; extracellular vesicles; neutral sphingomyelinase 2; tau

Online: 15 August 2023 (09:01:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1044.v1

Current Status of Angiogenesis Inhibitors as Second-Line Treatment for Unresectable Colorectal Cancer

Satoshi Otsu, Shuichi Hironaka

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer; second-line treatment; angiogenesis inhibitor; VEGF-A; VEGF-D

Online: 15 August 2023 (02:47:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0696.v1

An Observation of the Vitamin D Status in Highly Trained Adolescent Swimmers During the UK Autumn and Winter Months

Josh W. Newbury, Meghan A. Brown, Matthew Cole, Adam L. Kelly, Lewis Anthony Gough

Subject: Biology And Life Sciences, Other Keywords: vitamin D; supplements; sport nutrition; swimming; adolescent athletes.

Online: 9 August 2023 (09:49:06 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202307.2123.v1

Biosynthesis of Glucaric Acid by Recombinant Strain of Escherichia coli Expressing Two Different Urinate Dehydrogenases

Xinchao Yang, Linlin Niu, Chunjiang Ye, Yuanxiu Wang, Yuehui Liu, Fang Wang, Sun Naxin

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Urinate dehydrogenases; pETDuet-2×Ud; D-Glucaric acid; Glucuronic acid; SDS-PAGE

Online: 1 August 2023 (02:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1904.v2

The Indirect Effects of Vitamin D3 on the Aging Process According to Gender

Daniela Florina Trifan, Adrian Gheorghe Tirla, Calin Mos, Adrian Danciu, Florian Bodog, Felicia Manole, Timea Claudia Ghitea

Subject: Medicine And Pharmacology, Surgery Keywords: Face-lifting; vitamin D; collagen; sex difference

Online: 31 July 2023 (11:38:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.2105.v1

Patent Parasites: Non-Inventors Patenting Existing Open-Source Inventions in the 3-D Printing Technology Space

Apoorv Kulkarni, Joshua M. Pearce

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: 3-D printing; additive manufacturing; innovation; intellectual monopoly; intellectual property; open innovation; open hardware; open source; patent; RepRap

Online: 31 July 2023 (10:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2015.v1

Conservative Tryptophan Residue in the Vicinity of an Active Site of the M15 Family L, D-peptidases: A Key Element in the Catalysis

Galina V. Mikoulinskaia, Dmitry A. Prokhorov, Sergei V. Chernyshov, Daria S. Sitnikova, Arina G. Arakelian, Vladimir N. Uversky

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: L,D-peptidase; bacteriophage; catalysis; substrate binding; calcium

Online: 28 July 2023 (12:29:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1845.v1

Is Slovakia Almost a Hepatitis D Free Country?

Pavol Kristian, Ivana Hockicková, Elena Hatalová, Daniela Žilinčanová, Marek Rác, Veronika Bednárová, Patrícia Denisa Lenártová, Sylvia Dražilová, Ľubomír Skladaný, Ivan Schréter, Peter Jarčuška, Monika Halánová

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: hepatitis D; prevalence; anti-HDV antibody; HDV RNA

Online: 27 July 2023 (10:26:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1531.v1

Effects of Single Nucleotide Polymorphism BsmI of the Vitamin D Receptor (VDR) Gene on VDR, SOD-2, and CYP24A1 Gene Expression in Subjects with Low Serum Vitamin D Levels

Vanessa Rosa Retamoso, Fernanda Barbisan, Graziela Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Vieira Dos Santos, Lyana Berro Feijóo, Matias Nunes Frizzo, Ivana Beatrice Mânica Da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli

Subject: Public Health And Healthcare, Other Keywords: vitamin D; hypovitaminosis; Cytochorme P 450 (CYP); SOD2

Online: 21 July 2023 (13:21:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1140.v1

Key Nutrients for Optimal Blood Glucose Control and Mental Health in Individuals With Diabetes: A Review of the Evidence

Raedeh Basiri, Blessing Seidu, Lawrence J. Cheskin

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Diabetes; mental health; anxiety; depression; supplementation; nutrients; blood glucose; nutrition; omega-3 fatty acids; vitamin D; vitamin E; vitamin B6; vitamin B12; folate; selenium; chromium; iron; magnesium

Online: 18 July 2023 (09:10:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0898.v1

Risk Factors for Elevated D-Dimer Levels in Patients with Gastrointestinal Tumors Treated with Endoscopic Submucosal Dissection

Shougo Komatsuda, Shinya Kodashima, Ken Ikusaka, Naoaki Aoki, Yuki Shimizu, Minoru Oda, Fumito Harada, Taku Honda, Shingo Komazaki, Miyoko Sakurai, Daisuke Yanagisawa, Kyohei Maruyama, Hitoshi Aoyagi, Akari Isono, Ryo Miura, Koichiro Abe, Toshihiko Arizumi, Yoshinari Asaoka, Takatsugu Yamamoto, Atsushi Tanaka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: D-dimer; Deep-vein thrombosis; Endoscopic submucosal dissection; Gastrointestinal tumor; Sedative

Online: 13 July 2023 (08:09:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0548.v1

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring KLF4 Expression

Choulong Lee, Sunghye Cho, Dongtak Jeong

Subject: Biology And Life Sciences, Life Sciences Keywords: Cardiac dysfunction; Hypertension; Cardiac hypertrophy; Cardiac fibrosis; miR-25; KLF4; Angiotensin II; Inflammation; SERCA2a

Online: 10 July 2023 (08:43:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0484.v1

Cyclophilin D in Mitochondrial Dysfunction: a Key Player in Neurodegeneration?

Gabriele Coluccino, Valentina Pia Muraca, Alessandra Corazza, Giovanna Lippe

Subject: Biology And Life Sciences, Aging Keywords: Cyclophilin D (CyPD); mitochondrial permeability transition (mPTP); Alzheimer’s Disease (AD); Parkinson’s Disease (PD); mitochondria; neurodegeneration

Online: 7 July 2023 (11:06:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0307.v1

Changing Epidemiology of Viral Hepatitis in a Post-Soviet Country – the Case of Kyrgyzstan

Manas K. Akmatov, Nurgul J. Beisheeva, Asylbek Z. Nurmatov, Gulsunai J. Sattarova, Saikal N. Kylychbekova, Aisuluu A. Derkenbaeva, Zamira O. Abdrahmanova, Jana Prokein, Norman Klopp, Thomas Illig, Omor T. Kasymov, Zuridin S. Nurmatov, Frank Pessler

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: endemicity pattern; hepatitis A; hepatitis B; hepatitis C; hepatitis D; hepatitis E; seroprevalence; general population; Kyrgyzstan; post-Soviet country; WHO European Region

Online: 5 July 2023 (12:40:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0052.v1

Intraoperative Neurophysiological Monitoring in Syringomyelia Surgery: A Multimodal Approach

M. Angeles Sánchez Roldán, Dulce Moncho, Kimia Rahnama, Daniela Santa-Cruz, Elena Lainez, Daniel Baiget, Ivette Chocron, Dario Gandara, Agustin Bescos, Juan Sahuquillo, María A. Poca

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chiari malformation; corticospinal tract mapping; dorsal column mapping; D-wave; intraoperative neurophysiological monitoring; motor evoked potentials; root mapping; somatosensory evoked potentials; spinal cord; syringomyelia

Online: 3 July 2023 (11:53:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2207.v1

Expression of Phospholipase D Family Member 6 in Bovine Testes and Its Molecular Characteristics

Rui Yang, Bo-Yang Zhang, Wen-Qian Zhu, Chun-Ling Zhu, Lan-Xin Chen, Yan-sen Zhao, Yue-Qi Wang, Yan Zhang, Amjad Riaz, Bo Tang, Xue-Ming Zhang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Bovine; Bioinformatics; Phospholipase D family member 6; Testes; Spermatogonial stem cells

Online: 30 June 2023 (14:45:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2123.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (13:14:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2095.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (11:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1820.v1

A Genetic Algorithms Enhanced Sensor Marks Selection Algorithm For Advanced Photolithography Process

Aris Magklaras, Alefragkis Panagiotis, Christos Gogos, Christos Valouxis, Alexios Birbas

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Photolithography; Optimal Design of Experiments; Optimal Experimental Design; D-optimal; G-Optimal; A-Optimal; Control Algorithm; Optimization; Genetic Algorithms; Compound Criteria

Online: 26 June 2023 (14:02:17 CEST)

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In photolithography process, nanometer level precise, wavefront aberration models enable the machine to be able to meet the overlay (OVL) drift and critical dimension (CD) specifications. Software control algorithms take as input these models and correct any expected wavefront imperfections before reaching the wafer. In such way a near optimal image is exposed on the wafer surface. Optimizing the parameters of these models though, involves several time costly sensor measurements which reduce the throughput performance, in terms of exposed wafers per hour, of the machine. In that case, photolithography machines come across the trade-off between throughput and quality. Therefore one of the most common Optimal Experimental Design (OED) problems in photolithography machines (and not only) is how to choose the minimum amount of sensor measurements that will provide the maximum amount of information. Additionally, each sensor measurement corresponds to a point on the wafer surface and therefore we must measure uniformly around the wafer surface as well. In order to solve this problem, we propose a Sensor Marks Selection Algorithm which exploits Genetic Algorithms. The proposed solution first selects a pool of points that qualify as candidates to be selected in order to meet the uniformity constraint. Then, the point that provides the maximum amount of information, quantified by the Fisher based criteria of G, D and A-Optimality, is selected and added to the measurement scheme. This process though is considered "greedy", and for this reason Genetic Algorithms (GA) are exploited to further improve the solution. By repeating in parallel the "greedy" part several times we get an initial population that will be the input to our GA. This meta-heuristic approach outperforms the "greedy" approach significantly. The proposed solution is applied in a real life semiconductors industry use case and achieves interesting industry and academical results as well.

Preprint REVIEW | doi:10.20944/preprints202306.1785.v1

Preeclampsia and the Antiphospholipid Syndrome

Karoline Mayer-Pickel, Manurishi Nanda, Maja Gajic, Mila Cervar-Zivkovic

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: obstetric antiphospholipid syndrome; preeclampsia; prematurity; alternative therapy; vita-min D; curcumin; hydroxychloroquine

Online: 26 June 2023 (10:15:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1388.v1

Generating Robust Optimal Mixture Designs Due to Missing Observation Using a Multi-Objective Genetic Algorithm

Wanida Limmun, Boonorm Chomtee, John J. Borkowski

Subject: Computer Science And Mathematics, Mathematics Keywords: Genetic algorithm; Multi-objective functions; Missing observation; Mixture experiment; D-efficiency

Online: 20 June 2023 (10:59:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0746.v1

Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil

Filipe Ferreira de Almeida Rego, Laise de Moraes, Marta Giovannetti, José Adriano Góes Silva, Felipe Guimarães Torres, Marcio de Oliveira Silva, Maria da Purificação Pereira Da Silva, Johan Van Weyenbergh, Luciane Amorim Santos, Ricardo Khouri

Subject: Biology And Life Sciences, Virology Keywords: HIV-1 subtype D; Phylodynamics; Genomic surveillance

Online: 12 June 2023 (03:33:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0651.v1

Genetic Architecture of Vitamin D Deficiency Among an Elderly Lebanese Middle Eastern Population: An Exome-wide Association Study

Nagham Nafiz Hindi, Marlene Chakhtoura, Yaser Al-Sarraj, Dania Saleh Bacha, Omar Albagha, Ghada El-Hajj Fuleihan, Georges Nemer

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Exome-wide association stud; Vitamin D deficiency; genetic determinants; polygenic risk score; Middle Eastern population.

Online: 8 June 2023 (14:18:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0544.v1

Vitamin D Intake, Serum 25-hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: a Comprehensive Meta-meta-analysis including Meta-analyses of Randomized Controlled Trials and Observational Epidemiological Studies

Mehmet Emin Arayıcı, Yasemin Basbinar, Hulya Ellidokuz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; meta-analysis; vitamin D; mortality; incidence

Online: 7 June 2023 (11:11:20 CEST)

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It is a well-established fact that inadequate Vitamin D (Vit-D) levels have negative effects on the development and progression of malignant diseases, mainly cancer. The purpose of this paper was to elucidate the effects of Vit-D intake and serum 25-hydroxyvitamin-D (25(OH)D) levels on cancer incidence and mortality, the current evidence in this field, and the biases of this evidence using the meta-meta-analysis method. Meta-analyses focusing on Vit-D intake, serum 25(OH)D levels, and cancer risk/mortality were identified. A structured computer literature search was performed in PubMed/Medline, Web of Science (WoS), and Scopus electronic databases using predetermined keyword combinations. Primary and secondary meta-meta-analyses were carried out, combining odds ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) for outcomes reported in selected meta-analyses. A total of 35 eligible meta-analyses assessing the association between Vit-D and cancer incidence and/or mortality were included in this study. In the pooled analysis, higher Vit-D intake and serum 25(OH)D levels were associated with lower cancer risk (OR = 0.93, 95% CI: 0.90-0.96, p < 0.001; OR = 0.80, 95% CI: 0.72-0.89, p < 0.001, respectively) and cancer-related mortality (RR = 0.89, 95% CI: 0.86-0.93, p < 0.001; RR = 0.67, 95% CI: 0.58-0.78, p < 0.001, respectively). When meta-analyses whose primary reports included only randomized controlled trials were pooled, there was no significant association between Vit-D intake and cancer risk (OR = 0.99, 95% CI: 0.97-1.01, p = 0.320). In subgroup analysis, Vit-D consumption was associated with a significant decrease in colorectal and lung cancer incidence (OR = 0.89, 95% CI: 0.83-0.96, p = 0.002; OR = 0.88, 95% CI: 0.83-0.94, p < 0.001, respectively). Taken together, both Vit-D intake and higher 25(OH)D levels may provide remarkable benefits in terms of cancer incidence and mortality, however, careful evaluation according to cancer types is critically important and recommended.

Preprint ARTICLE | doi:10.20944/preprints202306.0322.v1

Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis

Daniela Roxana Matasariu, Cristina-Elena Mandici, Alexandra Ursache, Alexandra Irma Gabriela Bausic, Iuliana Elena Bujor, Alexandra Elena Cristofor, Elvira Bratila, Ludmila Lozneanu

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: phosphohistone H3; vitamin D; vitamin D receptor; progesterone; endometriosis; immunohistochemistry

Online: 5 June 2023 (13:14:21 CEST)

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