Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Vitamin D status in Bipolar Disorder

Zita Späth
,
Adelina Tmava-Berisha
* ,
Frederike T. Fellendorf
ORCID logo ,
Tatjana Stross
,
Alexander Maget
,
Martina Platzer
,
Susanne A. Bengesser
,
Alfred Häussl
ORCID logo ,
Ina Zwigl
,
Armin Birner
,
Robert Queissner
,
Katharina Stix
,
Linda Wels
,
Melanie Lenger
,
Nina Dalkner
ORCID logo ,
Sieglinde Zelzer
ORCID logo ,
Markus Herrmann
,
Eva Z. Reininghaus
ORCID logo
Version 1 : Received: 1 October 2023 / Approved: 2 October 2023 / Online: 2 October 2023 (03:58:38 CEST)

A peer-reviewed article of this Preprint also exists.

Späth, Z.; Tmava-Berisha, A.; Fellendorf, F.T.; Stross, T.; Maget, A.; Platzer, M.; Bengesser, S.A.; Häussl, A.; Zwigl, I.; Birner, A.; Queissner, R.; Stix, K.; Wels, L.; Lenger, M.; Dalkner, N.; Zelzer, S.; Herrmann, M.; Reininghaus, E.Z. Vitamin D Status in Bipolar Disorder. Nutrients 2023, 15, 4752. Späth, Z.; Tmava-Berisha, A.; Fellendorf, F.T.; Stross, T.; Maget, A.; Platzer, M.; Bengesser, S.A.; Häussl, A.; Zwigl, I.; Birner, A.; Queissner, R.; Stix, K.; Wels, L.; Lenger, M.; Dalkner, N.; Zelzer, S.; Herrmann, M.; Reininghaus, E.Z. Vitamin D Status in Bipolar Disorder. Nutrients 2023, 15, 4752.

Abstract

Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2D, and the vitamin D metabolite ratio (VMR) in BD and correlated the results with clinical affective symptomatology and functionality. The inactive precursor 25(OH)D and its principal catabolite 24,25(OH)2D were measured simultaneously with a validated liquid chromatography tandem mass-spectrometry method in 170 BD outpatients and 138 healthy controls. VMR was calculated as follows: VMR=100*(24,25(OH)2D/25(OH)D). The psychometric assessment enclosed: Beck Depression Inventory-II, Hamilton Depression Rating Scale, Young Mania Rating Scale, Global Assessment of Functioning, and number of suicide attempts. We did not find a significant difference between patients and controls in the concentrations of 25(OH)D and 24,25(OH)2D. Additionally, the VMR was comparable in both groups. The calculations for the clinical parameters showed a negative correlation between the Young Mania Rating Scale and 24,25(OH)2D (r = -.154, p = .040). Based on the small effect size and the predominantly euthymic sample, further exploitation in individuals with manic symptoms would be needed to confirm this association. In addition, long-term clinical markers, and an assessment in different phases of the disease may provide available additional insights.

Keywords

bipolar disorder; vitamin D metabolism; functional vitamin D deficiency; 25(OH)D; 24,25(OH)2D; VMR

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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