Version 1
: Received: 13 November 2023 / Approved: 14 November 2023 / Online: 14 November 2023 (09:44:34 CET)
How to cite:
Cordone, S.; Alfonsi, V.; De Gennaro, L. The Role of Sleep in Multiple Sclerosis. Preprints2023, 2023110897. https://doi.org/10.20944/preprints202311.0897.v1
Cordone, S.; Alfonsi, V.; De Gennaro, L. The Role of Sleep in Multiple Sclerosis. Preprints 2023, 2023110897. https://doi.org/10.20944/preprints202311.0897.v1
Cordone, S.; Alfonsi, V.; De Gennaro, L. The Role of Sleep in Multiple Sclerosis. Preprints2023, 2023110897. https://doi.org/10.20944/preprints202311.0897.v1
APA Style
Cordone, S., Alfonsi, V., & De Gennaro, L. (2023). The Role of Sleep in Multiple Sclerosis. Preprints. https://doi.org/10.20944/preprints202311.0897.v1
Chicago/Turabian Style
Cordone, S., Valentina Alfonsi and Luigi De Gennaro. 2023 "The Role of Sleep in Multiple Sclerosis" Preprints. https://doi.org/10.20944/preprints202311.0897.v1
Abstract
Multiple Sclerosis (MS) is a neurodegenerative disease that mainly affects young adults. The high prevalence of the disease and its impact on patients' quality of life led to priority being given to the etiopathogenesis of the disease to identify possible modifiable factors and consequent effective intervention strategies. Recent hypotheses suggest that the etiopathogenesis of MS is multifactorial and includes factors related to the immune system, neuroinflammation and neuro-degeneration. In this scenario, sleep has a close - although indirect - relationship with MS, through its relationship with each of those factors. In particular, the role of cytokines in immune system impairment and neuroinflammation, mitochondrial dysfunction and oxidative stress in neurodegeneration all are associated with sleep in different forms. Furthermore, melatonin in relation with vitamin D has a potential therapeutic effect in MS sleep-related problems. Given the growing interest of research in the mechanisms underlying MS and therapies able to alleviate MS-related symptoms at all stages of the disease, a more in-depth study of the role of sleep disturbances and the factors intrinsically related to sleep and MS could be useful both to investigate the etiopathogenetic factors of MS and to develop potential non-invasive intervention strategies for MS treatment.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
