Version 1
: Received: 5 June 2023 / Approved: 5 June 2023 / Online: 5 June 2023 (13:14:21 CEST)
How to cite:
Matasariu, D.R.; Mandici, C.; Ursache, A.; Bausic, A.I.G.; Bujor, I.E.; Cristofor, A.E.; Bratila, E.; Lozneanu, L. Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis. Preprints2023, 2023060322. https://doi.org/10.20944/preprints202306.0322.v1
Matasariu, D.R.; Mandici, C.; Ursache, A.; Bausic, A.I.G.; Bujor, I.E.; Cristofor, A.E.; Bratila, E.; Lozneanu, L. Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis. Preprints 2023, 2023060322. https://doi.org/10.20944/preprints202306.0322.v1
Matasariu, D.R.; Mandici, C.; Ursache, A.; Bausic, A.I.G.; Bujor, I.E.; Cristofor, A.E.; Bratila, E.; Lozneanu, L. Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis. Preprints2023, 2023060322. https://doi.org/10.20944/preprints202306.0322.v1
APA Style
Matasariu, D.R., Mandici, C., Ursache, A., Bausic, A.I.G., Bujor, I.E., Cristofor, A.E., Bratila, E., & Lozneanu, L. (2023). Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis. Preprints. https://doi.org/10.20944/preprints202306.0322.v1
Chicago/Turabian Style
Matasariu, D.R., Elvira Bratila and Ludmila Lozneanu. 2023 "Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis" Preprints. https://doi.org/10.20944/preprints202306.0322.v1
Abstract
(1) Background: To investigate the effect of phosphohistone H3 (PHH3) and vitamin D receptor (VDR) in the risk assessment of endometriosis, in two cohorts of women with this pathology, those receiving hormonal treatment, and those without treatment; (2) Methods: In 60 cases of women with endometriosis, the paraffin-embedded endometriosis tissue samples, retrieved after surgery, were immunohistochemically (IHC) analyzed aiming to determine the expression status of PHH3 and VDR; (3) Results: The IHC positive index of PHH3 and VDR of these two groups were compared. PHH3 levels were positively correlated with vitamin D levels, both being increased in patients without treatment. Within the group without treatment, PHH3 and VDR expressions were positively associated; (4) Conclusions: IHC analysis of PHH3 and VDR can be used as an additional tool for risk stratification and prognostic assessment in patients with endometriosis.
Keywords
phosphohistone H3; vitamin D; vitamin D receptor; progesterone; endometriosis; immunohistochemistry
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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