Methylation of the Vitamin D Receptor (VDR) gene in human disorders

Beatrice Gasperini; Angela Falvino; Eleonora Piccirilli; Umberto Tarantino; Annalisa Botta; Virginia Veronica Visconti

doi:10.20944/preprints202311.1315.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202311.1315.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Methylation of the Vitamin D Receptor (VDR) gene in human disorders

^* ,

Virginia Veronica Visconti

Version 1 : Received: 20 November 2023 / Approved: 21 November 2023 / Online: 21 November 2023 (10:47:16 CET)

A peer-reviewed article of this Preprint also exists.

Gasperini, B.; Falvino, A.; Piccirilli, E.; Tarantino, U.; Botta, A.; Visconti, V.V. Methylation of the Vitamin D Receptor Gene in Human Disorders. Int. J. Mol. Sci. 2024, 25, 107. Gasperini, B.; Falvino, A.; Piccirilli, E.; Tarantino, U.; Botta, A.; Visconti, V.V. Methylation of the Vitamin D Receptor Gene in Human Disorders. Int. J. Mol. Sci. 2024, 25, 107.

Abstract

The Vitamin D Receptor (VDR) mediates the actions of vitamin D, which has important roles in bone homeostasis, growth/differentiation of cells, immune functions and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.

Keywords

Vitamin D receptor (VDR); Epigenetics; DNA methylation; VDR-related diseases

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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