Version 1
: Received: 1 September 2023 / Approved: 4 September 2023 / Online: 6 September 2023 (03:34:19 CEST)
How to cite:
Avila, M.; Prado-Uribe, M.C.; Mora, C.; Cueto-Manzano, A.; Qureshi, A.R.; Lindholm, B.; Bernal-Amador, S.; Paniagua, R. Interaction of Vitamin D Receptor Polymorphism With Inflammation and Calcification Markers, Effect on All-Cause Mortality in Women on Dialysis. Preprints2023, 2023090292. https://doi.org/10.20944/preprints202309.0292.v1
Avila, M.; Prado-Uribe, M.C.; Mora, C.; Cueto-Manzano, A.; Qureshi, A.R.; Lindholm, B.; Bernal-Amador, S.; Paniagua, R. Interaction of Vitamin D Receptor Polymorphism With Inflammation and Calcification Markers, Effect on All-Cause Mortality in Women on Dialysis. Preprints 2023, 2023090292. https://doi.org/10.20944/preprints202309.0292.v1
Avila, M.; Prado-Uribe, M.C.; Mora, C.; Cueto-Manzano, A.; Qureshi, A.R.; Lindholm, B.; Bernal-Amador, S.; Paniagua, R. Interaction of Vitamin D Receptor Polymorphism With Inflammation and Calcification Markers, Effect on All-Cause Mortality in Women on Dialysis. Preprints2023, 2023090292. https://doi.org/10.20944/preprints202309.0292.v1
APA Style
Avila, M., Prado-Uribe, M.C., Mora, C., Cueto-Manzano, A., Qureshi, A.R., Lindholm, B., Bernal-Amador, S., & Paniagua, R. (2023). Interaction of Vitamin D Receptor Polymorphism With Inflammation and Calcification Markers, Effect on All-Cause Mortality in Women on Dialysis. Preprints. https://doi.org/10.20944/preprints202309.0292.v1
Chicago/Turabian Style
Avila, M., Sofia Bernal-Amador and Ramón Paniagua. 2023 "Interaction of Vitamin D Receptor Polymorphism With Inflammation and Calcification Markers, Effect on All-Cause Mortality in Women on Dialysis" Preprints. https://doi.org/10.20944/preprints202309.0292.v1
Abstract
Polymorphism of vitamin D3 receptor (VDR), has been associated with low bone mineral density and other immune and metabolic disorders; however, its impact on mortality of female dialysis patients is not well studied. This study aimed to identify bone mass-related factors, VDR gene polymorphism, and their interaction with morbid conditions that could influence all-cause mortality. In 246 female dialysis patients, age 43±11 years on continuous ambulatory dialysis peritoneal; 48%, haemodialysis; 23% and automated peritoneal dialysis; 29%. Tscore, Ca, PO4, albumin, hs-CRP, osteoprotegerin, fetuin, osteocalcin, iPTH, PINP and β-CTx were measured. PCR products were digested with Bsml to analyze VDR polymorphisms. Patients n=229; were followed for a median of 17 (15-31) months; 42 patients died. Bsml polymorphism, bb=64% and BB+Bb=36%. Hs-CRP was the risk of death in multivariate Cox Analysis. Patients with bb and inflammation had a higher risk of death (HR 2.48, 95% CI 1.08-5.68) persisted after adjustment for age, diabetes and iPTH (HR 2.33; 95% CI, 1.01-8.33) and after further adjustment for vintage, albumin, osteoprotegerin and vitamin D therapy (HR 3.49; 95% CI, 1.20-10.9). We may conclude that the presences of the bb genotype of VDR and inflammation have additive effects on all cause-mortality in females in CAPD, APD, and HD patients.
Keywords
bone mineral markers; phosphate/calcium homeostasis; dialysis; inflammation; mortality; vitamin D receptor polymorphism; diabetes; vascular calcification; hs-CRP; CKD
Subject
Medicine and Pharmacology, Urology and Nephrology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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